MCID: PRK045
MIFTS: 16

Parkinson Disease 5 malady

Summaries for Parkinson Disease 5

Sources:
47OMIM, 33MalaCards
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MalaCards: Parkinson Disease 5 is related to pick's disease and motor neuron disease. An important gene associated with Parkinson Disease 5 is UCHL1 (ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)), and among its related pathways is Neuroscience. The compounds vitamin b12 and choline have been mentioned in the context of this disorder. Related mouse phenotypes are hematopoietic system and renal/urinary system.

Description from OMIM:47 613643

Aliases & Classifications for Parkinson Disease 5

Sources:
47OMIM
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Aliases & Descriptions:

parkinson disease 5 47


Related Diseases for Parkinson Disease 5

Sources:
17GeneCards, 18GeneDecks
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Graphical network of diseases related to Parkinson Disease 5:



Diseases related to parkinson disease 5

Clinical Features for Parkinson Disease 5

Sources:
47OMIM
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Clinical features from OMIM:

613643

Drugs & Therapeutics for Parkinson Disease 5

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Parkinson Disease 5

Drug clinical trials:

Search ClinicalTrials for Parkinson Disease 5

Search NIH Clinical Center for Parkinson Disease 5

Search CenterWatch for Parkinson Disease 5

Genetic Tests for Parkinson Disease 5

Anatomical Context for Parkinson Disease 5

Animal Models for Parkinson Disease 5 or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Parkinson Disease 5:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.5MAPT, UCHL1, COMT
2MP:00053678.2MAPT, UCHL1, COMT

Publications for Parkinson Disease 5

Sources:
51PubMed
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Articles related to Parkinson Disease 5:

idTitleAuthorsYear
1
Interleukin-10 -1082A/G and -592C/A Polymorphisms with Risk of Parkinson's disease: A Meta-analysis. (24397502)
2014
2
Retractions: a89Cardiovascular dysautonomia in de novo Parkinson's diseasea89 J Neurol Sci 2006; 241:59a8965 and a89Cardiovascular autonomic dysfunction in dementia with Lewy bodies and Parkinson's diseasea89 J Neurol Sci 2007; 254:72a8977.a89. (18752810)
2011
3
Val-9Ala and Ile+58Thr polymorphism of MnSOD in Parkinson's disease. (20501330)
2010

Genetic Variations for Parkinson Disease 5

Sources:
63UniProtKB/Swiss-Prot
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Genetic disease variations for Parkinson Disease 5:

63
id Symbol AA change Variation SNP ID
1UCHL1p.Ile93MetVAR_015678

Expression for genes affiliated with Parkinson Disease 5

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Parkinson Disease 5

Search GEO for disease gene expression data for Parkinson Disease 5.

Pathways for genes affiliated with Parkinson Disease 5

Sources:
4Cell Signaling Technology
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Pathways related to Parkinson Disease 5 according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3MAPT, UCHL1

Compounds for genes affiliated with Parkinson Disease 5

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR
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Compounds related to Parkinson Disease 5 according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1vitamin b12459.3MAPT, COMT
2choline45 11 2411.3MAPT, COMT
3isoproterenol45 1110.2COMT, MAPT
4folate459.2COMT, MAPT
5nicotine45 50 29 1112.1COMT, MAPT
6nmda45 2910.1MAPT, COMT
7valine459.0MAPT, COMT
8methionine458.8MAPT, COMT
9dopamine45 29 11 2411.7MAPT, UCHL1, COMT
10cysteine458.7COMT, MAPT, UCHL1

GO Terms for genes affiliated with Parkinson Disease 5

Sources:
16Gene Ontology
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Cellular components related to Parkinson Disease 5 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.3MAPT, UCHL1

Biological processes related to Parkinson Disease 5 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1adult walking behaviorGO:0076289.3MAPT, UCHL1

Products for genes affiliated with Parkinson Disease 5

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Parkinson Disease 5

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet