Parkinson Disease 6, Early Onset: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Parkinson Disease 6, Early Onset

Sources:
⁴⁷OMIM, ³³MalaCards
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MalaCards: Parkinson Disease 6, Early Onset An important gene associated with Parkinson Disease 6, Early Onset is PINK1 (PTEN induced putative kinase 1).

Description from OMIM:⁴⁷ 605909

Aliases & Classifications for Parkinson Disease 6, Early Onset

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Sources:
⁴⁷OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear

Aliases & Descriptions:

parkinson disease 6, early onset ⁴⁷

Related Diseases for Parkinson Disease 6, Early Onset

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Diseases in the parkinson's disease family:

parkinson disease type 3	parkinson disease type 9
parkinson disease 6, early onset	parkinson disease 19, juvenile-onset
parkinson disease 10	parkinson disease, late-onset
parkinson disease 16	parkinson disease 13
parkinson disease 11	parkinson disease 18
parkinson disease 5	parkinson disease 4
parkinson disease 1	parkinson disease, juvenile, type 2
parkinson disease 8	parkinson disease 17
parkinson disease 20, early-onset	parkinson disease 14
parkinson disease 12

Clinical Features for Parkinson Disease 6, Early Onset

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Sources:
⁴⁷OMIM
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Clinical features from OMIM:

605909

Clinical synopsis from OMIM:

605909

Drugs & Therapeutics for Parkinson Disease 6, Early Onset

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Sources:
⁵CenterWatch, ⁴²NIH Clinical Center, ⁶ClinicalTrials
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Approved drugs:

Search CenterWatch for Parkinson Disease 6, Early Onset

Drug clinical trials:

Search ClinicalTrials for Parkinson Disease 6, Early Onset

Search NIH Clinical Center for Parkinson Disease 6, Early Onset

Search CenterWatch for Parkinson Disease 6, Early Onset

Genetic Tests for Parkinson Disease 6, Early Onset

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Anatomical Context for Parkinson Disease 6, Early Onset

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Animal Models for Parkinson Disease 6, Early Onset or affiliated genes

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Sources:
²⁸inGenious Targeting Laboratory
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inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions.

Publications for Parkinson Disease 6, Early Onset

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Genes related to Parkinson Disease 6, Early Onset

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Sources:
¹⁷GeneCards, ⁴⁶Novus Biologicals, ³²LifeSpan BioSciences, Inc., ²⁸inGenious Targeting Laboratory, ⁴⁷OMIM, ⁶³UniProtKB/Swiss-Prot
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Genes related to Parkinson Disease 6, Early Onset:

id	Symbol	Products	Description	Score	Implication
1	PINK1		PTEN induced putative kinase 1	31.28	Molecular basis known ⁴⁷ Causative variation ⁶³ GeneCards inferred : Disorders (show sections)

Products for genes related to Parkinson Disease 6, Early Onset disease:

id	Company	Proteins	Lysates	Antibodies	Knockout Mice
1	Novus Biologicals	1	1	1	-
2	LSBio	-	-	1	-
3	inGenious Targeting Laboratory	-	-	-

Genetic Variations for Parkinson Disease 6, Early Onset

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Sources:
⁶³UniProtKB/Swiss-Prot
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Genetic disease variations for Parkinson Disease 6, Early Onset:

⁶³ (show all 24)

id	Symbol	AA change	Variation
1	PINK1	p.Gly309Asp	VAR_018994
2	PINK1	p.Cys92Phe	VAR_046568
3	PINK1	p.Arg147His	VAR_046574
4	PINK1	p.Ala168Pro	VAR_046575
5	PINK1	p.Pro196Leu	VAR_046577
6	PINK1	p.Ala217Asp	VAR_046578
7	PINK1	p.Glu240Lys	VAR_046581
8	PINK1	p.Leu268Val	VAR_046584
9	PINK1	p.His271Gln	VAR_046585
10	PINK1	p.Arg279His	VAR_046587
11	PINK1	p.Thr313Met	VAR_046589
12	PINK1	p.Leu347Pro	VAR_046593
13	PINK1	p.Cys388Arg	VAR_046596
14	PINK1	p.Glu417Gly	VAR_046599
15	PINK1	p.Arg464His	VAR_046605
16	PINK1	p.Leu489Pro	VAR_046607
17	PINK1	p.Cys125Gly	VAR_062773
18	PINK1	p.Ala280Thr	VAR_062774
19	PINK1	p.Leu369Pro	VAR_062775
20	PINK1	p.Gly386Ala	VAR_062776
21	PINK1	p.Pro399Leu	VAR_062777
22	PINK1	p.Arg407Gln	VAR_062778
23	PINK1	p.Gly409Val	VAR_062779
24	PINK1	p.Gln126Pro	VAR_064344