Parkinson Disease 6, Early Onset malady

MalaCards: Parkinson Disease 6, Early Onset, also known as parkinson disease, is related to lrrk2-related parkinson disease and autosomal recessive juvenile parkinson disease. An important gene associated with Parkinson Disease 6, Early Onset is PINK1 (PTEN induced putative kinase 1). The drugs bromocriptine and pergolide have been mentioned in the context of this disorder.

OMIM: 605909

parkinson disease 6, early onset 33 parkinson disease 43

Diseases related to parkinson disease 6, early onset by text searches and GeneDecks gene sharing:

(show all 43)

id	Related Disease	Score	Top Affiliating Genes
1	lrrk2-related parkinson disease	8.2
2	autosomal recessive juvenile parkinson disease	7.9
3	htra2-related parkinson disease	7.7
4	pink1 type of young-onset parkinson disease	7.7
5	parkinson disease type 3	7.7
6	parkin type of juvenile parkinson disease	7.5
7	park7-related parkinson disease	7.5
8	snca-related parkinson disease	7.5
9	essential tremor	7.5
10	parkinson disease type 9	7.2
11	parkinson disease 10	7.2
12	tremor	7.2
13	parkinson disease 14	6.8
14	parkinson disease 4	6.8
15	parkinson disease 1	6.8
16	parkinson disease, resistance to	6.8
17	postencephalitic parkinson disease	6.8
18	secondary parkinson disease	6.8
19	parkinson disease multi-gene panels	6.8
20	parkinson disease 7, autosomal recessive early-onset	6.8
21	parkinson disease 12	6.8
22	parkinson disease-16	6.8
23	parkinson disease, juvenile, type 2	6.8
24	parkinson disease 11	6.8
25	parkinson disease 15, autosomal recessive	6.8
26	vps35-related parkinson disease	6.3
27	fbxo7-related parkinson disease	6.3
28	frontotemporal dementia	6.3
29	lewy body dementia	6.3
30	parkinson disease 5	6.3
31	paralysis agitans, juvenile, of hunt	6.3
32	pathological gambling	6.3
33	tauopathy	5.4
34	alcoholism	5.4
35	torsion dystonia	5.4
36	bell's palsy	5.4
37	wolff-parkinson-white syndrome	5.4
38	corticobasal degeneration	5.4
39	dysphagia	5.4
40	lung cancer	5.4
41	oculopharyngeal muscular dystrophy	5.4
42	pallidopyramidal syndrome	5.4
43	prolidase deficiency	5.4

Clinical features from OMIM: 605909

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 amantadine, amantadine hydrochloride, benztropine, benztropine mesylate, biperiden, biperiden hydrochloride, biperiden lactate, bromocriptine, bromocriptine mesylate, cabergoline, carbidopa, entacapone, levodopa, pergolide, pergolide mesylate, pramipexole, pramipexole dihydrochloride, ropinirole, ropinirole hydrochloride, selegiline, selegiline hydrochloride, tolcapone, trihexyphenidyl, trihexyphenidyl hydrochloride

Genes related to parkinson disease 6, early onset according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	PINK1	PTEN induced putative kinase 1	11.1	Disorders