Parkinson Disease 6, Early Onset: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Aliases & Classifications for Parkinson Disease 6, Early Onset

Sources:
¹¹Disease Ontology, ¹²diseasecard, ²⁷GTR, ³⁷MedGen, ³⁹MeSH, ⁵²OMIM, ⁶⁴The Human Phenotype Ontology, ⁶⁸UMLS, ⁷⁰UniProtKB/Swiss-Prot
See all MalaCards sources

Aliases & Descriptions for Parkinson Disease 6, Early Onset:

Name: Parkinson Disease 6, Early Onset ⁵² ¹²

Parkinson Disease Autosomal Recessive Early-Onset Digenic Pink1/dj1 ⁷⁰ ²⁷

Autosomal Recessive Early-Onset Parkinson Disease Type 6 ⁷⁰ ²⁷

Parkinson Disease 6 ⁷⁰ ²⁷

Parkinson Disease 6, Autosomal Recessive Early-Onset ⁶⁸

Autosomal Recessive Early-Onset Parkinson Disease 6 ¹¹

Parkinson Disease 6 Late-Onset Susceptibility to ⁷⁰

Early-Onset Parkinson Disease 6 ¹¹

Parkinson Disease 6 Early-Onset ⁷⁰

Parkinsonism Young Adult Onset ⁷⁰

Park6 ⁷⁰

Characteristics:

HPO:

⁶⁴

parkinson disease 6, early onset:
Inheritance: autosomal recessive inheritance
Onset and clinical course: infantile onset, slow progression

Classifications:

MalaCards categories:
Global: Genetic diseases, Rare diseases, Metabolic diseases
Anatomical: Neuronal diseases, Mental diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM⁵² 605909

Disease Ontology¹¹ DOID:0060369

MedGen³⁷ C1853833, C1970035, C2751533

MeSH³⁹ D010300, D020734

Summaries for Parkinson Disease 6, Early Onset

Sources:
¹¹Disease Ontology, ³⁶MalaCards, ⁵²OMIM, ⁷⁰UniProtKB/Swiss-Prot
See all MalaCards sources

UniProtKB/Swiss-Prot:⁷⁰ Parkinson disease 6: A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.

MalaCards based summary: Parkinson Disease 6, Early Onset, also known as parkinson disease autosomal recessive early-onset digenic pink1/dj1, is related to parkinson disease, juvenile, type 2 and parkinson disease, late-onset, and has symptoms including muscle rigidity, muscle rigidity and bradykinesia. An important gene associated with Parkinson Disease 6, Early Onset is PINK1 (PTEN Induced Putative Kinase 1), and among its related pathways are PI3K / Akt Signaling and Parkinsons Disease Pathway. Related mouse phenotypes are pigmentation and cellular.

Disease Ontology:¹¹ A Parkinson's disease that has material basis in mutations in the PINK1 gene on chromosome 1p36.12.

Description from OMIM:⁵² 605909

Related Diseases for Parkinson Disease 6, Early Onset

Sources:
²⁰GeneAnalytics, ²¹GeneCards
See all MalaCards sources

Diseases in the Parkinson Disease, Late-Onset family:

Parkinson Disease 7, Autosomal Recessive Early-Onset	parkinson disease 6, early onset
Parkinson Disease 19, Juvenile-Onset	Parkinson Disease 10
Parkinson Disease 16	Parkinson Disease 13
Parkinson Disease 11	Parkinson Disease 21
Parkinson Disease 18	Parkinson Disease 5
Parkinson Disease 4	Parkinson Disease 1
Parkinson Disease, Juvenile, Type 2	Parkinson Disease 8
Parkinson Disease 17	Parkinson Disease 20, Early-Onset
Parkinson Disease 15, Autosomal Recessive	Parkinson Disease 14, Autosomal Recessive
Parkinson Disease 12	Juvenile Onset Parkinson Disease 19a
Juvenile-Onset Parkinson Disease	Early-Onset Parkinson Disease
Lrrk2-Related Parkinson Disease	Parkinson Disease Type 3
Parkinson Disease Type 9	Dnajc6-Related Parkinson Disease
Eif4g1-Related Parkinson Disease	Gigyf2-Related Parkinson Disease
Pla2g6-Related Parkinson Disease	Synj1-Related Parkinson Disease
Fbxo7-Related Parkinson Disease	Htra2-Related Parkinson Disease
Park7-Related Parkinson Disease	Snca-Related Parkinson Disease
Vps35-Related Parkinson Disease	Hereditary Late-Onset Parkinson Disease
Parkinson Disease 22	Parkinson Disease 23, Autosomal Recessive, Early Onset

Diseases related to Parkinson Disease 6, Early Onset via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)

id	Related Disease	Score	Top Affiliating Genes
1	parkinson disease, juvenile, type 2	11.1
2	parkinson disease, late-onset	11.0
3	multiple system atrophy	10.1	PARK7, PINK1
4	enteropathica	10.1	MT-ND5, MT-ND6
5	retromolar area cancer	10.1	MT-ND5, MT-ND6
6	ndp-related retinopathies	10.1	MT-ND5, MT-ND6
7	nerve fibre bundle defect	10.0	MT-ND5, MT-ND6
8	allergic contact dermatitis of eyelid	10.0	MT-ND5, MT-ND6
9	kufor-rakeb syndrome	9.9	ATP13A2, PARK7, PINK1
10	spink1-related hereditary pancreatitis	9.9	LRRK2, PARK7
11	mucinous intrahepatic cholangiocarcinoma	9.9	MT-ND5, MT-ND6
12	meier-gorlin syndrome 5	9.9	LRRK2, PARK7
13	ceroid lipofuscinosis, neuronal, 1	9.8	LRRK2, PARK7, PINK1
14	lethal congenital contracture syndrome 8	9.8	LRRK2, PARK7, PINK1
15	trichothiodystrophy 3, photosensitive	9.8	LRRK2, PARK7, PINK1
16	hypoproteinemia, hypercatabolic	9.8	LRRK2, PARK7, PINK1
17	cavernous hemangioma	9.8	LRRK2, PARK7, PINK1
18	hemochromatosis, type 2a	9.8	LRRK2, PARK7, PINK1
19	substance-induced psychosis	9.8	LRRK2, PARK7, PINK1
20	plekhm1-related autosomal recessive osteopetrosis	9.7	ATP13A2, LRRK2, PARK7
21	thrombosis	9.6	ATP13A2, LRRK2, PARK7, PINK1
22	klippel-feil syndrome 4, autosomal recessive, with myopathy and facial dysmorphism	9.6	ATP13A2, LRRK2, PARK7, PINK1
23	gallbladder adenoma	9.6	ATP13A2, LRRK2, PARK7, PINK1

Graphical network of the top 20 diseases related to Parkinson Disease 6, Early Onset:

Symptoms & Phenotypes for Parkinson Disease 6, Early Onset

Sources:
⁴¹MGI, ⁵²OMIM, ⁶⁴The Human Phenotype Ontology, ⁶⁸UMLS
See all MalaCards sources

Symptoms by clinical synopsis from OMIM:

605909

Clinical features from OMIM:

605909

Human phenotypes related to Parkinson Disease 6, Early Onset:

⁶⁴ (show all 11)

id	Description	HPO Source Accession
1	urinary urgency⁶⁴	HP:0000012
2	depression⁶⁴	HP:0000716
3	dementia⁶⁴	HP:0000726
4	anxiety⁶⁴	HP:0000739
5	parkinsonism⁶⁴	HP:0001300
6	dystonia⁶⁴	HP:0001332
7	hyperreflexia⁶⁴	HP:0001347
8	rigidity⁶⁴	HP:0002063
9	bradykinesia⁶⁴	HP:0002067
10	postural instability⁶⁴	HP:0002172
11	resting tremor⁶⁴	HP:0002322

UMLS symptoms related to Parkinson Disease 6, Early Onset:

muscle rigidity, bradykinesia

MGI Mouse Phenotypes related to Parkinson Disease 6, Early Onset according to GeneCards Suite gene sharing:

⁴¹

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	pigmentation	MP:0001186	8.5	ATP13A2, LRRK2, PTEN
2	cellular	MP:0005384	7.9	ATP13A2, LRRK2, MT-ND6, PARK7, PINK1, PTEN
3	nervous system	MP:0003631	7.8	ATP13A2, LRRK2, MT-ND6, PARK7, PINK1, PTEN

Drugs & Therapeutics for Parkinson Disease 6, Early Onset

Sources:
¹BitterDB, ⁴ClinicalTrials, ¹⁰DGIdb, ¹⁴DrugBank, ²⁹HMDB, ³³IUPHAR, ⁵⁰Novoseek, ⁵⁶PharmGKB
See all MalaCards sources

Drugs for Parkinson Disease 6, Early Onset (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)

id

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Pramipexole

approved, investigational

Phase 4

139

104632-26-0

59868, 119570

Synonyms:

(-)-Pramipexole

(6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine

(6S)-N(6)-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine

(6S)-N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine

(S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole

(S)-N 6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine

104632-26-0

111GE001

2-amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole

2-amino-6-propylaminotetrahydrobenzothiazole

AC1L3P1T

BIDD:GT0250

C10H17N3S

CHEBI:8356

CHEMBL301265

CID119570

CPD000449298

D05575

DivK1c_006916

Furfuryl Acetate

HMS2051A21

HMS2090C15

KBio1_001860

KBio2_002340

KBio2_004908

KBio2_007476

KBioSS_002343

LS-40722

MLS000758250

MLS001423952

Mirapex

MolPort-003-849-957

NCGC00167441-01

Pramipexol

Pramipexol [Spanish]

Pramipexole

Pramipexole (USAN/INN)

Pramipexole 2HCl Monohydrate

Pramipexole [USAN:INN]

Pramipexole hydrochloride

Pramipexolum

Pramipexolum [Latin]

SAM001247006

SBB070477

SMR000449298

SND-919

SUD919CL2Y

SpecPlus_000820

Spectrum5_001453

Spectrum_001838

U-98528E

pramipexole

2

Dopamine

approved

Phase 4

3836

51-61-6, 62-31-7

681

Synonyms:

(3H)-Dopamine

.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride

.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane

1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)

1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride

1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium

153C5321-5FEE-4B0B-8925-F388F0EEEBD1

2-(3,4-Dihydroxyphenyl)ethylamine

2-(3,4-dihydroxyphenyl)ethylamine

2-benzenediol

3,4-Dihydroxyphenethylamine

3,4-Dihydroxyphenethylamine hydrochloride

3,4-Dihydroxyphenylethylamine

3,4-dihydroxyphenethylamine

3-Hydroxtyramine

3-Hydroxytyramine

3-Hydroxytyramine Hydrobromide

3-Hydroxytyramine hydrochloride

4-(2-Aminoethyl)-1,

4-(2-Aminoethyl)-1,2-benzenediol

4-(2-Aminoethyl)-1,2-bezenediol

4-(2-Aminoethyl)-Pyrocatechol

4-(2-Aminoethyl)benzene-1,2-diol

4-(2-Aminoethyl)catechol

4-(2-Aminoethyl)pyrocatechol

4-(2-Aminoethyl)pyrocatechol hydrochloride

4-(2-aminoethyl)-pyrocatechol

50444-17-2

51-61-6

62-31-7 (HYDROCHLORIDE)

AC1L19S5

AC1Q54AX

AC1Q54AY

AKOS003790978

ASL 279

BIDD:ER0506

BPBio1_001123

BSPBio_001932

Biomol-NT_000001

C03758

CHEBI:18243

CHEMBL59

CID681

D07870

DB00988

Deoxyepinephrine

DivK1c_000780

Dopamin

Dopamina

Dopamina [INN-Spanish]

Dopamine

Dopamine (INN)

Dopamine (USAN)(*hydrochloride*)

Dopamine [INN:BAN]

Dopaminum

Dopaminum [INN-Latin]

Dopastat

Dophamine

Dynatra

EINECS 200-110-0

HSDB 3068

Hydroxytyramin

Hydroxytyramine

IDI1_000780

IP 498

Intropin

Intropin [*hydrochloride*]

KBio1_000780

KBio2_001492

KBio2_002388

KBio2_002484

KBio2_004060

KBio2_004956

KBio2_005052

KBio2_006628

KBio2_007524

KBio2_007620

KBio3_001152

KBio3_002867

KBio3_002962

KBioGR_001129

KBioGR_002388

KBioGR_002484

KBioSS_001492

KBioSS_002393

KBioSS_002491

KW-3-060

L-DOPAMINE

L000232

LDP

LS-159

Lopac-H-8502

Lopac0_000586

Medopa (TN)

MolPort-001-641-000

NCGC00015519-01

NCGC00015519-08

NCGC00096050-01

NCGC00096050-02

NCGC00096050-03

NCGC00096050-04

NCGC00096050-05

NINDS_000780

NSC 173182

NSC169105

NSC173182

Oprea1_088821

Oxytyramine

Pyrocatechol, 4-(2-aminoethyl)- (8CI)

Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride

Revimine

Revivan

SPBio_001205

SPECTRUM1505155

ST048774

STK301601

Spectrum2_001023

Spectrum3_000406

Spectrum4_000525

Spectrum5_000945

Spectrum_001012

UNII-VTD58H1Z2X

UPCMLD0ENAT5885989:001

a-(3,4-Dihydroxyphenyl)-b-aminoethane

alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane

cMAP_000036

cMAP_000065

dopamine

hydroxytyramine

intropin

m-Hydroxytyramine hydrochloride

nchembio.105-comp9

nchembio.107-comp4

nchembio.284-comp1

nchembio.78-comp16

nchembio.89-comp3

nchembio705-8

nchembio801-comp8

3

Protective Agents

Phase 4, Phase 3

7443

4

Antioxidants

Phase 4

3050

5

Neurotransmitter Agents

Phase 4, Phase 3, Early Phase 1

18340

6

Dopamine agonists

Phase 4

632

7

Antiparkinson Agents

Phase 4

1574

8

Dopamine Agents

Phase 4

3836

9

Rivastigmine

approved, investigational

Phase 3

83

123441-03-2

77991

Synonyms:

(S)-3-(1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate

123441-03-2

3-((1S)-1-(Dimethylamino)ethyl)phenyl N-ethyl-N-methylcarbamate

3-((1S)-1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate

3-[(1S)-1-(dimethylamino)ethyl]phenyl ethyl(methyl)carbamate

AB1004572

AC1L2U92

BIDD:GT0316

C11766

CHEMBL636

CID77991

Carbamic acid, N-ethyl-N-methyl-, 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester

Carbamic acid, ethylmethyl-, 3-((1S)-1-(dimethylamino)ethyl)phenyl ester

D03822

DB00989

ENA 713 free base

Ena 713 Free Base

Ethylmethylcarbamic acid 3-((1S)-1-(dimethylamino)ethyl)phenyl ester

Exelon

Exelon Patch

HMS2089H18

I06-2037

LS-172571

MolPort-003-666-662

NCGC00167531-01

Rivastigmine (JAN/USAN/INN)

Rivastigmine Hydrogen Tartrate

Rivastigmine [USAN:INN]

Rivastigmine hydrogen tartrate

SDZ 212-713

UNII-PKI06M3IW0

[3-[(1S)-1-(dimethylamino)ethyl]phenyl] N-ethyl-N-methylcarbamate

m-((S)-1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate

rivastigmine

10

Neuroprotective Agents

Phase 3

1716

11

Cholinergic Agents

Phase 3

3992

12

Cholinesterase Inhibitors

Phase 3

592

13

Fluorodeoxyglucose F18

Phase 2

412

14

Histamine

approved, investigational

Early Phase 1

1050

75614-87-8, 51-45-6

774

Synonyms:

.beta.-Imidazolyl-4-ethylamine

1H-Imidazole-4-ethanamine

1H-Imidazole-5-ethanamine

1avn

1qft

2-(1H-Imidazol-4-yl)ethanamine

2-(1H-Imidazol-4-yl)ethylamine

2-(1H-Imidazol-5-yl)ethanamine

2-(1H-Imidazol-5-yl)ethylamine

2-(1H-imidazol-4-yl)ethan-1-amine

2-(1H-imidazol-5-yl)ethanamine

2-(3H-Imidazol-4-yl)-ethylamine

2-(4-Imidazolyl)ethanamine

2-(4-Imidazolyl)ethylamine

2-(4-imidazolyl)ethylamine

2-Imidazol-4-yl-Ethylamine

2-Imidazol-4-ylethylamine

2-[4-Imidazolyl]ethylamine

4-(2-Aminoethyl)-1H-imidazole

4-(2-Aminoethyl)imidazole

4-Imidazoleethylamine

4-imidazoleethylamine

5-Imidazoleethylamine

5-imidazoleethylamine

51-45-6

53290_FLUKA

64422-25-9

924364-91-0

AC-13185

AC1L19ZT

AC1Q54BV

AC1Q54BW

AKOS000274386

ALBB-005968

BCBcMAP01_000250

BSPBio_001117

BSPBio_002124

Bio1_000487

Bio1_000976

Bio1_001465

Bio2_000389

Bio2_000869

C00388

CCRIS 6535

CHEBI:18295

CHEMBL90

CID774

D08040

DivK1c_000308

EINECS 200-100-6

Eramin

Ergamine

Ergotidine

F411C768-A159-4FC0-A195-291A08BB03AA

Free histamine

H7125_SIGMA

HMS1362G19

HMS1792G19

HMS1990G19

HSDB 3338

HSM

Histamine

Histamine (DCF)

Histamine Base

Histamine [USAN]

Histamine, Free Base

Histaminum

Histaminum (TN)

IDI1_000308

IDI1_002144

Imidazole-4-ethylamine

Istamina

Istamina [Italian]

KBio1_000308

KBio2_000457

KBio2_001325

KBio2_003025

KBio2_003893

KBio2_005593

KBio2_006461

KBio3_000853

KBio3_000854

KBio3_001344

KBioGR_000457

KBioGR_001580

KBioSS_000457

KBioSS_001325

L-Histamin base

L-Histamine

L-histamine

L000292

LS-75835

Lopac-H-7250

Lopac0_000595

MLS000069447

MolPort-001-785-597

MolPort-002-042-264

NCGC00015513-01

NCGC00015513-08

NCGC00093371-02

NCGC00093371-03

NCGC00093371-04

NCGC00093371-05

NINDS_000308

NSC 33792

NSC33792

SDCCGMLS-0066601.P001

SMP1_000151

SMR000059091

SPBio_000729

ST073926

STK346752

STOCK5S-55669

Spectrum2_000665

Spectrum3_000452

Spectrum4_000960

Spectrum5_000796

Spectrum_000845

Theramine

UNII-820484N8I3

WLN: T5M CNJ D2Z

ZERO/004089

[3H]histamine

b-Imidazolyl-4-ethylamine

beta-Aminoethylglyoxaline

beta-Aminoethylimidazole

beta-Aminothethylglyoxaline

beta-Imidazolyl-4-ethylamine

beta-aminoethylglyoxaline

beta-aminoethylimidazole

beta-aminothethylglyoxaline

bmse000744

histamine

nchembio.87-comp54

nchembio714-comp1

15

Doxepin

approved

Early Phase 1

13

1668-19-5

667477, 667468

Synonyms:

(3E)-3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine

(3E)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine

(3Z)-3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-di(methyl)propan-1-amine

(3Z)-3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine

(3Z)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine

(Z)-Doxepin

11-(3-(Dimethylamino)propylidene)-6H-dibenz(b,e)oxepine

11-(3-Dimethylamino-propyliden)-6,11-dihydro-dibenz(b,e)oxipin

11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz(b,e)oxipin

1668-19-5

3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine

3-Dibenz[b,e]oxepin-11(6H)-ylidene-N,N-dimethyl-1-propanamine

3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine

3607-18-9

AC1L1FAW

AC1LDI5F

AC1LDI63

AC1NUW4A

AKOS001582771

Adapin

Aponal

BPBio1_000118

BRD-K36616567-003-01-5

BRD-K37694030-003-02-8

BRD-K54462405-003-03-3

BSPBio_000106

BSPBio_001934

C06971

C19H21NO

CAS-1229-29-4

CCRIS 9176

CHEBI:36691

CHEBI:36692

CHEBI:4710

CHEMBL101740

CID10039438

CID3158

CID5462131

CID667468

CID667477

Cidoxepin

Cidoxepin [INN]

Cidoxepina

Cidoxepinum

Curatin

D07875

DB01142

DivK1c_000431

Doxepin

Doxepin (INN)

Doxepin (Z)-isomer

Doxepin Hcl

Doxepin Hydrochloride,

Doxepin [USAN]

Doxepin, Hydrochloride

Doxepina

Doxepina [INN-Spanish]

Doxepine

Doxepinum

Doxepinum [INN-Latin]

HSDB 3069

IDI1_000431

KBio1_000431

KBio2_001285

KBio2_003853

KBio2_006421

KBio3_001154

KBioGR_001131

KBioSS_001285

L000699

LS-174582

LS-61638

Lopac-D-4526

Lopac0_000339

MF 10

MOLI001594

MolPort-003-847-024

MolPort-005-933-834

N,N-Dimethyldibenz(b,e)oxepin-delta(11(6H),gamma)-propylamine

NCGC00015344-01

NCGC00015344-02

NCGC00015344-04

NCGC00024623-01

NCGC00024623-02

NCGC00162127-01

NINDS_000431

Oprea1_473232

Prestwick0_000263

Prestwick1_000263

Prestwick2_000263

Prestwick3_000263

Quitaxon

SPBio_000206

SPBio_002325

Sinequan

Sinequan (TN)

Spectrum2_000133

Spectrum3_000407

Spectrum4_000526

Spectrum5_001051

Spectrum_000805

Tocris-0508

Triadapin

UNII-5ASJ6HUZ7D

UNII-F96TTB8728

Zonalon

cis-N-(3-(6H-Dibenz(b,e)oxepin-11-yliden)propyl)-N,N-dimethylamin

cis-doxepin

doxepin

16

Zopiclone

approved

Early Phase 1

26

43200-80-2

5735

Synonyms:

(+-)-Zopiclone

(+-)-zopiclone

(±)-zopiclone

1-Piperazinecarboxylic acid, 4-methyl-, 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo(3,4-b)pyrazin-5-yl ester

1-Piperazinecarboxylic acid, 4-methyl-, 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl ester

138680-07-6

27267 R.P

27267 R.P.

4-Methyl-1-piperazinecarboxylic acid 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl ester

4-Methyl-1-piperazinecarboxylic acid ester with 6-(5-chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo(3,4-b)pyrazin-5-one

43200-80-2

6-(5-Chloro-2-pyridinyl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methyl-1-piperazinecarboxylate

6-(5-chloro-2-pyridyl)-6,7-dihydro- 7-oxo-5H-pyrrolo(3,4-b)pyrazin-5-yl 4-methyl-1- piperazinecarboxylate

6-(5-chloropyrid-2-yl)-5-(4-methylpiperazin-1-yl)carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine

6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate

AC1L1L0T

AbZ brand of zopiclone

Aliud brand of zopiclone

Alpharma brand of zopiclone

Amoban

Amoban (TN)

Amovane

Aventis Pharma brand of zopiclone

Aventis brand of zopiclone

Azupharma brand of zopiclone

BPBio1_001146

BRD-A34309505-001-08-5

BRN 0768704

Bio-0528

Biomol-NT_000284

C17H17ClN6O3

C515050

CHEBI:32315

CHEBI:324263

CHEMBL135400

CID5735

Ciclum brand of zopiclone

Clonmel brand of zopiclone

D01372

DB01198

Dolorgeit brand of zopiclone

EINECS 256-138-9

EU-0101270

Gerard brand of zopiclone

Hexal brand of zopiclone

Hormosan brand of zopiclone

Imovance

Imovane

Italfarmaco brand of zopiclone

LS-110937

Limovan

Lopac0_001270

MLS000028547

MLS000083579

MLS001201837

MLS001304058

Merck dura brand of zopiclone

MolPort-002-507-850

NCGC00024993-03

NCGC00024993-04

Norton brand of zopiclone

Novo-zopiclone

Nu-Pharm brand of zopiclone

Nu-Zopiclone

Optidorm

Opus brand of zopiclone

Pinewood brand of zopiclone

RP 27 267

RP 27267

RP-27267

Ran-zopiclone

Ratiopharm brand of zopiclone

Rhodiapharm brand of zopiclone

Rhone-Poulenc Rorer brand of zopiclone

Rhovane

S1446_Selleck

SMR000048685

STK599439

Siaten

Sopivan

Stadapharm brand of zopiclone

TAD brand of zopiclone

Temmler brand of zopiclone

Teva brand of zopiclone

UNII-03A5ORL08Q

Ximovan

Z 4900

Z4900_SIGMA

Zileze

Zimoclone

Zimovane

Zopi-Puren

Zopicalm

Zopicalma

Zopiclon AL

Zopiclon AZU

Zopiclon AbZ

Zopiclon Stada

Zopiclon TAD

Zopiclon beta

Zopiclon-TEVA

Zopiclon-neuraxpharm

Zopiclon-ratiopharm

Zopiclona

Zopiclona [INN-Spanish]

Zopiclone

Zopiclone (JAN/INN)

Zopiclone (TN)

Zopiclone [BAN:INN:JAN]

Zopiclone [Ban:Inn:Jan]

Zopiclone, Imovane, Zimovane, Lunesta

Zopiclonum

Zopiclonum [INN-Latin]

Zopitan

Zorclone

[6-(5-chloropyridin-2-yl)-5-oxo-7H-pyrrolo[3,4-b]pyrazin-7-yl] 4-methylpiperazine-1-carboxylate

betapharm brand of zopiclone

ct-Arzneimittel brand of zopiclone

nchembio747-comp16

neuraxpharm brand of zopiclone

ratio-Zopiclone

zopiclodura

zopiclon von ct

zopiclone

17

Ethanol

approved

2137

64-17-5

702

Synonyms:

(C6-C9)Alkyl alcohol

02483_FLUKA

02851_FLUKA

02853_FLUKA

02854_FLUKA

02855_FLUKA

02856_FLUKA

02856_SIAL

02857_FLUKA

02857_SIAL

02858_FLUKA

02858_SIAL

02860_FLUKA

02865_FLUKA

02865_SIAL

02870_FLUKA

02870_SIAL

02875_FLUKA

02877_FLUKA

02878_FLUKA

02882_FLUKA

02882_SIAL

02883_FLUKA

02884_FLUKA

02890_FLUKA

02890_SIAL

02891_FLUKA

02891_SIAL

1-Hydroxyethane

100C.NPA

121182-78-3

187380_ALDRICH

187380_SIAL

24102_RIEDEL

24102_SIAL

24103_RIEDEL

24103_SIAL

24105_RIEDEL

24105_SIAL

24106_RIEDEL

24106_SIAL

24194_RIEDEL

24194_SIAL

245119_ALDRICH

245119_SIAL

270741_ALDRICH

270741_SIAL

277649_ALDRICH

277649_SIAL

2858_SIGMA

29221_FLUKA

32205_RIEDEL

32205_SIAL

32221_RIEDEL

32221_SIAL

32294_RIEDEL

32294_SIAL

34870_SIAL

34963_RIEDEL

39278_FLUKA

40210_ALDRICH

40210_RIEDEL

41322_FLUKA

458600_ALDRICH

458600_SIAL

459828_ALDRICH

459828_SIAL

459836_ALDRICH

459836_SIAL

459844_SIAL

48075_SUPELCO

493511_SIAL

493538_ALDRICH

493538_SIAL

493546_ALDRICH

493546_SIAL

64-17-5

676829_SIAL

68475-56-9

71076-86-3

71329-38-9

8000-16-6

8024-45-1

AC1L19TW

AC1Q31MM

AHD 2000

AI3-01706

ALCOHOL 5% IN D5-W

Absolute Alcohol

Absolute Ethanol

Absolute alcohol

Absolute ethanol

Absolute ethyl alcohol

Aethanol

Aethanol [German]

Aethylalkohol

Alcare Hand Degermer

Alcohol

Alcohol (USP)

Alcohol (ethyl)

Alcohol Anhydrous

Alcohol [USP]

Alcohol anhydrous

Alcohol dehydrated

Alcohol denatured

Alcohol etílico

Alcohol, Absolute

Alcohol, Dehydrated

Alcohol, Diluted

Alcohol, Grain

Alcohol, anhydrous

Alcohol, dehydrated

Alcohol, denatured

Alcohol, diluted

Alcohol, ethyl

Alcohols

Alcohols, C1-3

Alcohols, C30

Alcohols, C6-9

Alcool Ethylique

Alcool Etilico

Alcool ethylique

Alcool etilico

Alcool éthylique

Algrain

Alkohol

Alkohol [German]

Alkoholu Etylowego

Alkoholu etylowego

Aminoethanol

Anhydrol

Anhydrol PM 4085

Anhydrous alcohol

Anhydrous ethanol

Beta-Aminoethanol

Beta-Aminoethyl Alcohol

Beta-Ethanolamine

Beta-Hydroxyethylamine

C00469

C2H5OH

C2H6O

CCRIS 945

CDA 19

CDA 19-200

CHEBI:16236

CHEMBL545

CID702

Caswell No. 426

Caswell No. 430

Colamine

Cologne Spirit

Cologne spirit

Cologne spirits

D000431

D00068

DB00898

Dehydrated Ethanol

Dehydrated alcohol

Dehydrated ethanol

Denatured Alcohol

Denatured Alcohol Cd-10

Denatured Alcohol Cd-5

Denatured Alcohol Cd-5a

Denatured Alcohol Sd-1

Denatured Alcohol Sd-13a

Denatured Alcohol Sd-17

Denatured Alcohol Sd-23a

Denatured Alcohol Sd-28

Denatured Alcohol Sd-30

Denatured Alcohol Sd-39b

Denatured Alcohol Sd-39c

Denatured Alcohol Sd-3a

Denatured Alcohol Sd-40m

Denatured Ethanol

Denatured alcohol

Denatured ethanol

Desinfektol EL

Diluted Alcohol

Distilled spirits

E2385_SIGMA

E7023_ALDRICH

E7023_SIAL

E7148_ALDRICH

E7148_SIAL

E7517_SIGMA

EINECS 200-578-6

EINECS 270-649-4

EOH

EOX

ETA

Envision Conditioner Pdd 9020

Esumiru WK 88

EtOH

Etanolo

Etanolo [Italian]

Ethanol (9CI)

Ethanol 200 Proof

Ethanol 200 proof

Ethanol Absolute

Ethanol Absolute Bp

Ethanol Anhydrous

Ethanol Extra Pure

Ethanol Vapor

Ethanol [JAN]

Ethanol solution

Ethanol, Silent Spirit

Ethanol, undenatured

Ethanolum anhydricum

Ethicap

Ethyl Alcohol

Ethyl Alcohol & Water, 10%

Ethyl Alcohol & Water, 20%

Ethyl Alcohol & Water, 30%

Ethyl Alcohol & Water, 40%

Ethyl Alcohol & Water, 5%

Ethyl Alcohol & Water, 50%

Ethyl Alcohol & Water, 60%

Ethyl Alcohol & Water, 70%

Ethyl Alcohol & Water, 80%

Ethyl Alcohol & Water, 95%

Ethyl Alcohol & Water, 96%

Ethyl Alcohol Anhydrous

Ethyl Alcohol, Anhydrous

Ethyl Alcohol, Denatured

Ethyl Hydrate

Ethyl Hydroxide

Ethyl alc

Ethyl alcohol

Ethyl alcohol anhydrous

Ethyl alcohol in alcoholic beverages

Ethyl alcohol usp

Ethyl hydrate

Ethyl hydroxide

Ethylalcohol

Ethylalcohol [Dutch]

Ethylol

Ethylolamine

Ethyloxy Group

Etylowy alkohol

FEMA No. 2419

FEMA Number 2419

Fermentation alcohol

Glycinol

Grain alcohol

HSDB 531

HSDB 82

HYDROXYETHYL GROUP

Hinetoless

Hydroxyethane

I14-12648

IMS 99

Infinity Pure

Jaysol

Jaysol S

LS-1539

LTBB002977

Lux

Methylated Spirit Mineralised

Methylated spirit

Methylcarbinol

MolPort-001-785-844

Molasses alcohol

NCGC00091458-01

NCI-C03134

NSC 85228

NSC85228

Oxydimethylene Group

Potato alcohol

Punctilious ethyl alcohol

Pyro

QMHAIh@

Reagent Alcohol

Ru-Tuss Expectorant

SDA 3A

SDA 40-2

SDM No. 37

SY Fresh M

Sekundasprit

Silent spirit

Spirit

Spirits of wine

Spiritus vini

Spirt

Synasol

Tecsol

Tecsol C

Thanol

Thiofaco M-50

UNII-3K9958V90M

USAF EK-1597

Undenatured Ethanol

WLN: Q2

absolute alcohol

alcohol

alcohol etilico

bmse000297

etanol

ethanol

ethyl alcohol

grain alcohol

nchem.651-comp3c

nchembio.552-comp10

nchembio.94-comp20

spiritus vini

Äthanol

Äthylalkohol

éthanol

18

Psychotropic Drugs

Early Phase 1

6430

19

Hypnotics and Sedatives

Early Phase 1

2616

20

Histamine Antagonists

Early Phase 1

961

21

Antidepressive Agents, Tricyclic

Early Phase 1

304

22

Histamine Phosphate

Early Phase 1

1049

51-74-1

65513

Synonyms:

1H-Imidazole-4-ethanamine, phosphate (1:2)

2-Imidazol-4-ylethylamine orthophosphoric acid (1:2)

4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate)

4-(2-Aminoethyl)imidazole di-acid phosphate

4-2(2-Aminoethyl)Imidazole-Di-Acid Phosphate

51-74-1

53623-99-7

74-56-6

AC1L23E4

CID65513

D04445

DB00667

EINECS 200-118-4

H0147

Histamine acid phosphate

Histamine biphosphate

Histamine dihydrogen phosphate

Histamine diphosphate

Histamine phosphate (1:2)

Histamine phosphate (TN)

Histamine phosphate (USP)

Histamine phosphate [USP]

Histamine positive

LS-78569

UNII-QWB37T4WZZ

23

Central Nervous System Depressants

Early Phase 1

13403

24

Antidepressive Agents

Early Phase 1

2736

25

Phenylethyl Alcohol

37

Interventional clinical trials:

(show all 13)

id	Name	Status	NCT ID	Phase
1	Study of (Mirapex) Pramipexole for the Early Treatment of Parkinsons Disease (PD)	Completed	NCT00321854	Phase 4
2	Efficacy of RIVAstigmine on Motor, Cognitive and Behavioural Impairment in Progressive Supranuclear Palsy	Recruiting	NCT02839642	Phase 3
3	Development of a Novel 18F-DTBZ PET Imaging as a Biomarker to Monitor Neurodegeneration of PARK6 and PARK8 Parkinsonism	Completed	NCT01759888	Phase 2
4	A Trial of MitoQ for the Treatment of People With Parkinson's Disease	Completed	NCT00329056	Phase 2
5	Imaging and Genetic Biomarkers of Parkinson Disease (PD) Onset and Progression in High-risk Families	Completed	NCT00273351	Phase 2
6	Parkin Mutations and Their Functional Consequences	Unknown status	NCT00136721	Phase 1
7	Functional Characterization of Parkin + Patients	Terminated	NCT00142311	Phase 1
8	Genetic Study in Young Onset Parkinson's Disease	Unknown status	NCT01529970
9	Treatments for Insomnia in Patients With Parkinson's Disease	Completed	NCT01489982	Early Phase 1
10	Hereditary Parkinson s Disease Natural History Protocol	Recruiting	NCT02511015
11	The Swedish BioFINDER 2 Study	Recruiting	NCT03174938
12	Early Parkinson's Disease (PD) Cross-Sectional	Terminated	NCT00817453
13	Unique Brainstem Biomarkers of Early Parkinson's Disease	Terminated	NCT02761707

Search NIH Clinical Center for Parkinson Disease 6, Early Onset

Genetic Tests for Parkinson Disease 6, Early Onset

Sources:
²⁷GTR
See all MalaCards sources

Genetic tests related to Parkinson Disease 6, Early Onset:

id	Genetic test	Affiliating Genes
1	Parkinson Disease 6, Autosomal Recessive Early-Onset²⁷
2	Parkinson Disease 6²⁷
3	Parkinson Disease, Autosomal Recessive Early-Onset, Digenic, Pink1/dj1²⁷

Anatomical Context for Parkinson Disease 6, Early Onset

Publications for Parkinson Disease 6, Early Onset

Genes related to Parkinson Disease 6, Early Onset

Sources:
⁵Clinvar, ²¹GeneCards, ⁵²OMIM, ⁷⁰UniProtKB/Swiss-Prot
See all MalaCards sources

Genes related to Parkinson Disease 6, Early Onset (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication	PubmedIds
1	PINK1	PTEN Induced Putative Kinase 1	1218.88	Molecular basis known ⁵² Pathogenic ⁵ Causative variation ⁷⁰ GeneCards inferred via : Disorders (show sections)	15349870, 20301402, 20301792 more 23279440, 15970950, 15955953, 16966503
2	MT-ND5	Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 5	43.88	Risk factor ⁵ GeneCards inferred via : Disorders (show sections)	18524835, 20301402, 20301792 more 23279440
3	MT-ND6	Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 6	43.88	Risk factor ⁵ GeneCards inferred via : Disorders (show sections)	18524835, 20301402, 20301792 more 23279440
4	ATP13A2	ATPase 13A2	18.88	GeneCards inferred via : Disorders (show sections)
5	PTEN	Phosphatase And Tensin Homolog	18.88	GeneCards inferred via : Disorders (show sections)
6	LRRK2	Leucine Rich Repeat Kinase 2	18.88	GeneCards inferred via : Disorders (show sections)
7	PARK7	Parkinsonism Associated Deglycase	18.88	GeneCards inferred via : Disorders (show sections)

Variations for Parkinson Disease 6, Early Onset

Sources:
⁵Clinvar, ⁹dbSNP, ⁷⁰UniProtKB/Swiss-Prot
See all MalaCards sources

UniProtKB/Swiss-Prot genetic disease variations for Parkinson Disease 6, Early Onset:

⁷⁰ (show all 22)

id	Symbol	AA change	Variation ID	SNP ID
1	PINK1	p.Gly309Asp	VAR_018994	rs74315355
2	PINK1	p.Cys92Phe	VAR_046568
3	PINK1	p.Ala168Pro	VAR_046575	rs768091663
4	PINK1	p.Pro196Leu	VAR_046577	rs138302371
5	PINK1	p.Ala217Asp	VAR_046578	rs74315360
6	PINK1	p.Glu240Lys	VAR_046581	rs573931674
7	PINK1	p.Leu268Val	VAR_046584	rs372280083
8	PINK1	p.His271Gln	VAR_046585	rs28940284
9	PINK1	p.Arg279His	VAR_046587	rs74315358
10	PINK1	p.Thr313Met	VAR_046589	rs74315359
11	PINK1	p.Leu347Pro	VAR_046593	rs28940285
12	PINK1	p.Cys388Arg	VAR_046596
13	PINK1	p.Glu417Gly	VAR_046599
14	PINK1	p.Arg464His	VAR_046605	rs764328076
15	PINK1	p.Leu489Pro	VAR_046607
16	PINK1	p.Cys125Gly	VAR_062773
17	PINK1	p.Ala280Thr	VAR_062774	rs772510148
18	PINK1	p.Leu369Pro	VAR_062775
19	PINK1	p.Gly386Ala	VAR_062776
20	PINK1	p.Arg407Gln	VAR_062778	rs556540177
21	PINK1	p.Gly409Val	VAR_062779
22	PINK1	p.Gln126Pro	VAR_064344

Clinvar genetic disease variations for Parkinson Disease 6, Early Onset:

⁵ (show all 15)

id	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	PINK1	NM_ 032409.2(PINK1): c.620delG (p.Arg207Glnfs)	deletion	Pathogenic	rs756677845	GRCh37	Chr 1, 20964567: 20964567
2	PINK1	NM_ 032409.2(PINK1): c.926G> A (p.Gly309Asp)	SNV	Pathogenic	rs74315355	GRCh37	Chr 1, 20971132: 20971132
3	PINK1	NM_ 032409.2(PINK1): c.813C> A (p.His271Gln)	SNV	Pathogenic	rs28940284	GRCh37	Chr 1, 20971019: 20971019
4	PINK1	NM_ 032409.2(PINK1): c.1311G> A (p.Trp437Ter)	SNV	Pathogenic	rs74315356	GRCh37	Chr 1, 20975547: 20975547
5	PINK1	NM_ 032409.2(PINK1): c.736C> T (p.Arg246Ter)	SNV	Pathogenic	rs74315357	GRCh37	Chr 1, 20966445: 20966445
6	PINK1	NM_ 032409.2(PINK1): c.1040T> C (p.Leu347Pro)	SNV	Pathogenic	rs28940285	GRCh37	Chr 1, 20972133: 20972133
7	PINK1	NM_ 032409.2(PINK1): c.1570_ 1573dupTTAG (p.Asp525Valfs)	duplication	Pathogenic	rs730880302	GRCh37	Chr 1, 20977008: 20977011
8	PINK1	PINK1, 3-BP INS, 1602CAA	insertion	Pathogenic
9	PINK1	NM_ 032409.2(PINK1): c.836G> A (p.Arg279His)	SNV	Pathogenic	rs74315358	GRCh37	Chr 1, 20971042: 20971042
10	PINK1	NM_ 005216.4(DDOST): c.807_ 5409del	deletion	Pathogenic		GRCh38	Chr 1, 20646970: 20651572
11	PINK1	NM_ 032409.2(PINK1): c.938C> T (p.Thr313Met)	SNV	Pathogenic	rs74315359	GRCh37	Chr 1, 20971144: 20971144
12	PINK1	NM_ 032409.2(PINK1): c.650C> A (p.Ala217Asp)	SNV	Pathogenic	rs74315360	GRCh37	Chr 1, 20964597: 20964597
13	PINK1	NM_ 032409.2(PINK1): c.1366C> T (p.Gln456Ter)	SNV	Pathogenic	rs45539432	GRCh37	Chr 1, 20975602: 20975602
14	MT-ND6	m.14319T> C	SNV	risk factor	rs199476110	GRCh37	Chr MT, 14319: 14319
15	MT-ND5	m.12397A> G	SNV	risk factor	rs200890363	GRCh37	Chr MT, 12397: 12397

Expression for genes affiliated with Parkinson Disease 6, Early Onset

Sources:
¹⁸Gene Expression Omnibus DataSets
See all MalaCards sources

Search GEO for disease gene expression data for Parkinson Disease 6, Early Onset.

Pathways for genes affiliated with Parkinson Disease 6, Early Onset

Sources:
³Cell Signaling Technology, ³⁴KEGG, ⁴²NCBI BioSystems Database, ⁵⁵PathCards, ⁶⁰Reactome
See all MalaCards sources

Pathways related to Parkinson Disease 6, Early Onset according to GeneCards Suite gene sharing:

id	Super pathways	Score	Top Affiliating Genes
1	PI3K / Akt Signaling³	9.3	PARK7, PTEN
2	Parkinsons Disease Pathway⁴²	8.8	LRRK2, PARK7, PINK1
3	Neuroscience³	8.2	ATP13A2, LRRK2, PARK7, PINK1
4	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.⁶⁰ Show member pathways Huntington's disease³⁴ The citric acid (TCA) cycle and respiratory electron transport⁶⁰ Respiratory electron transport⁶⁰ Complex I biogenesis⁶⁰ Alzheimer's disease³⁴ Alzheimers Disease⁴² Non-alcoholic fatty liver disease (NAFLD)³⁴ Parkinson's disease³⁴ Electron Transport Chain⁴² Formation of ATP by chemiosmotic coupling⁶⁰ Oxidative phosphorylation³⁴ Oxidative phosphorylation⁴²	7.9	LRRK2, MT-ND5, MT-ND6, PARK7, PINK1

GO Terms for genes affiliated with Parkinson Disease 6, Early Onset

Sources:
¹⁹Gene Ontology
See all MalaCards sources

Cellular components related to Parkinson Disease 6, Early Onset according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	cell body	GO:0044297	10.3	PARK7, PINK1
2	mitochondrial intermembrane space	GO:0005758	10.3	PARK7, PINK1
3	mitochondrial respiratory chain complex I	GO:0005747	10.3	MT-ND5, PARK7
4	respiratory chain	GO:0070469	9.6	MT-ND5, MT-ND6
5	axon	GO:0030424	9.5	LRRK2, PARK7, PINK1
6	mitochondrial inner membrane	GO:0005743	9.2	LRRK2, MT-ND5, MT-ND6, PINK1
7	mitochondrion	GO:0005739	8.4	LRRK2, MT-ND5, PARK7, PINK1, PTEN
8	neuron projection	GO:0043005	8.1	ATP13A2, LRRK2, MT-ND5, PARK7, PTEN

Biological processes related to Parkinson Disease 6, Early Onset according to GeneCards Suite gene sharing:

(show all 31)

id	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrial electron transport, NADH to ubiquinone	GO:0006120	10.3	MT-ND5, MT-ND6
2	mitochondrial respiratory chain complex I assembly	GO:0032981	10.3	MT-ND5, MT-ND6
3	activation of protein kinase B activity	GO:0032148	10.3	PARK7, PINK1
4	negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway	GO:1903384	10.3	PARK7, PINK1
5	negative regulation of oxidative stress-induced cell death	GO:1903202	10.3	PARK7, PINK1
6	negative regulation of oxidative stress-induced neuron death	GO:1903204	10.3	PARK7, PINK1
7	positive regulation of mitochondrial electron transport, NADH to ubiquinone	GO:1902958	10.2	PARK7, PINK1
8	positive regulation of peptidyl-serine phosphorylation	GO:0033138	10.2	PARK7, PINK1
9	positive regulation of protein kinase B signaling	GO:0051897	10.2	PARK7, PINK1
10	regulation of mitochondrial membrane potential	GO:0051881	10.1	PARK7, PINK1
11	regulation of mitochondrion organization	GO:0010821	10.1	ATP13A2, PINK1
12	regulation of mitophagy	GO:1903146	10.1	ATP13A2, PINK1
13	regulation of neuron apoptotic process	GO:0043523	10.1	PARK7, PINK1
14	negative regulation of autophagosome assembly	GO:1902902	10.0	LRRK2, PINK1
15	negative regulation of macroautophagy	GO:0016242	10.0	LRRK2, PINK1
16	positive regulation of protein ubiquitination	GO:0031398	9.9	LRRK2, PINK1
17	cellular response to manganese ion	GO:0071287	9.8	ATP13A2, LRRK2
18	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	GO:1902236	9.8	LRRK2, PARK7
19	negative regulation of hydrogen peroxide-induced cell death	GO:1903206	9.8	LRRK2, PARK7
20	negative regulation of protein binding	GO:0032091	9.8	LRRK2, PARK7
21	regulation of synaptic vesicle transport	GO:1902803	9.7	LRRK2, PINK1
22	canonical Wnt signaling pathway	GO:0060070	9.7	LRRK2, PTEN
23	negative regulation of excitatory postsynaptic potential	GO:0090394	9.7	LRRK2, PTEN
24	positive regulation of sequence-specific DNA binding transcription factor activity	GO:0051091	9.6	PARK7, PINK1, PTEN
25	protein stabilization	GO:0050821	9.5	PARK7, PINK1, PTEN
26	autophagy	GO:0006914	9.5	LRRK2, PARK7, PINK1
27	mitochondrion organization	GO:0007005	9.4	LRRK2, PARK7, PINK1
28	negative regulation of neuron death	GO:1901215	9.3	ATP13A2, LRRK2, PARK7
29	negative regulation of protein phosphorylation	GO:0001933	9.2	LRRK2, PARK7, PTEN
30	response to hydrogen peroxide	GO:0042542	9.1	MT-ND5, MT-ND6, PARK7
31	cellular response to oxidative stress	GO:0034599	8.9	ATP13A2, LRRK2, PARK7, PINK1

Molecular functions related to Parkinson Disease 6, Early Onset according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	cupric ion binding	GO:1903135	9.9	ATP13A2, PARK7
2	NADH dehydrogenase (ubiquinone) activity	GO:0008137	9.9	MT-ND5, MT-ND6
3	ubiquitin-specific protease binding	GO:1990381	9.3	PARK7, PTEN