MCID: PRK020
MIFTS: 46

Parkinson Disease 6, Early Onset malady

Categories: Genetic diseases, Neuronal diseases, Mental diseases, Rare diseases, Metabolic diseases

Aliases & Classifications for Parkinson Disease 6, Early Onset

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Aliases & Descriptions for Parkinson Disease 6, Early Onset:

Name: Parkinson Disease 6, Early Onset 50 12
Parkinson Disease Autosomal Recessive Early-Onset Digenic Pink1/dj1 68 25
Autosomal Recessive Early-Onset Parkinson Disease Type 6 68 25
Early-Onset Parkinson Disease 6 11 13
Parkinson Disease 6 68 25
Park6 11 68
 
Parkinson Disease 6, Autosomal Recessive Early-Onset 66
Autosomal Recessive Early-Onset Parkinson Disease 6 11
Parkinson Disease 6 Late-Onset Susceptibility to 68
Parkinson Disease 6 Early-Onset 68
Parkinsonism Young Adult Onset 68

Characteristics:

HPO:

62
parkinson disease 6, early onset:
Inheritance: autosomal recessive inheritance
Onset and clinical course: infantile onset, slow progression


Classifications:



External Ids:

OMIM50 605909
Disease Ontology11 DOID:0060369

Summaries for Parkinson Disease 6, Early Onset

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UniProtKB/Swiss-Prot:68 Parkinson disease 6: A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.

MalaCards based summary: Parkinson Disease 6, Early Onset, also known as parkinson disease autosomal recessive early-onset digenic pink1/dj1, is related to parkinson disease, late-onset and parkinson disease, juvenile, type 2, and has symptoms including muscle rigidity, muscle rigidity and bradykinesia. An important gene associated with Parkinson Disease 6, Early Onset is PINK1 (PTEN Induced Putative Kinase 1), and among its related pathways are Mitophagy and Alpha-synuclein signaling. Related mouse phenotypes are cellular and nervous system.

Disease Ontology:11 A parkinson's disease caused by mutations in the pink1 gene located on chromosome 1p36.12.

Description from OMIM:50 605909

Related Diseases for Parkinson Disease 6, Early Onset

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Diseases in the Parkinson Disease, Late-Onset family:

Parkinson Disease 7, Autosomal Recessive Early-Onset parkinson disease 6, early onset
Parkinson Disease 19, Juvenile-Onset Parkinson Disease 10
Parkinson Disease 16 Parkinson Disease 13
Parkinson Disease 11 Parkinson Disease 21
Parkinson Disease 18 Parkinson Disease 5
Parkinson Disease 4 Parkinson Disease 1
Parkinson Disease, Juvenile, Type 2 Parkinson Disease 8
Parkinson Disease 17 Parkinson Disease 20, Early-Onset
Parkinson Disease 15, Autosomal Recessive Parkinson Disease 14, Autosomal Recessive
Parkinson Disease 12 Lrrk2-Related Parkinson Disease
Parkinson Disease Type 3 Parkinson Disease Type 9
Dnajc6-Related Parkinson Disease Eif4g1-Related Parkinson Disease
Gigyf2-Related Parkinson Disease Pla2g6-Related Parkinson Disease
Synj1-Related Parkinson Disease Fbxo7-Related Parkinson Disease
Htra2-Related Parkinson Disease Park7-Related Parkinson Disease
Snca-Related Parkinson Disease Vps35-Related Parkinson Disease
Hereditary Late-Onset Parkinson Disease Parkinson Disease 22
Parkinson Disease 23, Autosomal Recessive, Early Onset

Diseases related to Parkinson Disease 6, Early Onset via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 27)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson disease, late-onset28.2LRRK2, MT-ND5, PARK2, PARK7, PINK1
2parkinson disease, juvenile, type 211.2
3clubfoot10.3MT-ND5, MT-ND6
4enchondroma10.3MT-ND5, MT-ND6
5childhood cerebral astrocytoma10.3MT-ND5, MT-ND6
6noninfectious dermatoses of eyelid10.3MT-ND5, MT-ND6
7mitochondrial membrane protein-associated neurodegeneration10.2MT-ND5, MT-ND6
8lymphoepithelioma-like carcinoma10.2MT-ND5, MT-ND6
9tinea nigra10.1MT-ND5, MT-ND6
10myoclonic epilepsy associated with ragged-red fibers10.1MT-ND5, MT-ND6
11coenzyme q10 deficiency, primary, 19.8PARK2, PARK7, PINK1
12whiplash9.7LRRK2, PARK2
13parkinson disease 19.6LRRK2, PARK2
14essential tremor9.5LRRK2, PARK2
15phka2-related phosphorylase kinase deficiency9.4LRRK2, PARK2, PARK7
16meier-gorlin syndrome 59.3LRRK2, PARK2, PARK7
17polycystic kidney disease 29.3LRRK2, PARK2
18kufor-rakeb syndrome9.2ATP13A2, FBXO7, PARK7, PINK1
19parkinson disease 109.1LRRK2, PARK2, PARK7, PINK1
20klippel-feil syndrome 4, autosomal recessive, with myopathy and facial dysmorphism9.1ATP13A2, FBXO7, PARK2, PARK7
21celiac disease 129.1LRRK2, PARK2, PARK7, PINK1
22epilepsy, progressive myoclonic 1b9.1LRRK2, PARK2, PARK7, PINK1
23mast syndrome9.1LRRK2, PARK2, PARK7, PINK1
24angiomyolipoma9.0LRRK2, PARK2, PARK7, PINK1
25chronic intestinal vascular insufficiency9.0LRRK2, PARK2, PARK7, PINK1
26adrenal gland pheochromocytoma8.5ATP13A2, LRRK2, PARK2, PARK7, PINK1
27parkinson disease 6, early onset7.2ATP13A2, FBXO7, LRRK2, MT-ND5, MT-ND6, PARK2

Graphical network of the top 20 diseases related to Parkinson Disease 6, Early Onset:



Diseases related to parkinson disease 6, early onset

Symptoms for Parkinson Disease 6, Early Onset

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Symptoms by clinical synopsis from OMIM:

605909

Clinical features from OMIM:

605909

HPO human phenotypes related to Parkinson Disease 6, Early Onset:

(show all 11)
id Description Frequency HPO Source Accession
1 urinary urgency HP:0000012
2 depression HP:0000716
3 dementia HP:0000726
4 anxiety HP:0000739
5 parkinsonism HP:0001300
6 dystonia HP:0001332
7 hyperreflexia HP:0001347
8 rigidity HP:0002063
9 bradykinesia HP:0002067
10 postural instability HP:0002172
11 resting tremor HP:0002322

UMLS symptoms related to Parkinson Disease 6, Early Onset:


muscle rigidity, bradykinesia

Drugs & Therapeutics for Parkinson Disease 6, Early Onset

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Drugs for Parkinson Disease 6, Early Onset (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
PramipexolePhase 4137104632-26-059868, 119570
Synonyms:
(-)-Pramipexole
(6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
(6S)-N(6)-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
(6S)-N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
(S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole
(S)-N  6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
104632-26-0
111GE001
2-amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole
2-amino-6-propylaminotetrahydrobenzothiazole
AC1L3P1T
BIDD:GT0250
C10H17N3S
CHEBI:8356
CHEMBL301265
CID119570
CPD000449298
D05575
DivK1c_006916
Furfuryl Acetate
HMS2051A21
HMS2090C15
KBio1_001860
KBio2_002340
KBio2_004908
 
KBio2_007476
KBioSS_002343
LS-40722
MLS000758250
MLS001423952
Mirapex
MolPort-003-849-957
NCGC00167441-01
Pramipexol
Pramipexol [Spanish]
Pramipexole
Pramipexole (USAN/INN)
Pramipexole 2HCl Monohydrate
Pramipexole [USAN:INN]
Pramipexole hydrochloride
Pramipexolum
Pramipexolum [Latin]
SAM001247006
SBB070477
SMR000449298
SND-919
SUD919CL2Y
SpecPlus_000820
Spectrum5_001453
Spectrum_001838
U-98528E
pramipexole
2Dopamine agonistsPhase 4611
3
DopaminePhase 4367851-61-6, 62-31-7681
Synonyms:
(3H)-Dopamine
.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane
1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium
153C5321-5FEE-4B0B-8925-F388F0EEEBD1
2-(3,4-Dihydroxyphenyl)ethylamine
2-(3,4-dihydroxyphenyl)ethylamine
2-benzenediol
3,4-Dihydroxyphenethylamine
3,4-Dihydroxyphenethylamine hydrochloride
3,4-Dihydroxyphenylethylamine
3,4-dihydroxyphenethylamine
3-Hydroxtyramine
3-Hydroxytyramine
3-Hydroxytyramine Hydrobromide
3-Hydroxytyramine hydrochloride
4-(2-Aminoethyl)-1,
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)-1,2-bezenediol
4-(2-Aminoethyl)-Pyrocatechol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
4-(2-Aminoethyl)pyrocatechol hydrochloride
4-(2-aminoethyl)-pyrocatechol
50444-17-2
51-61-6
62-31-7 (HYDROCHLORIDE)
AC1L19S5
AC1Q54AX
AC1Q54AY
AKOS003790978
ASL 279
BIDD:ER0506
BPBio1_001123
BSPBio_001932
Biomol-NT_000001
C03758
CHEBI:18243
CHEMBL59
CID681
D07870
DB00988
Deoxyepinephrine
DivK1c_000780
Dopamin
Dopamina
Dopamina [INN-Spanish]
Dopamine
Dopamine (INN)
Dopamine (USAN)(*hydrochloride*)
Dopamine [INN:BAN]
Dopaminum
Dopaminum [INN-Latin]
Dopastat
Dophamine
Dynatra
EINECS 200-110-0
HSDB 3068
Hydroxytyramin
Hydroxytyramine
IDI1_000780
IP 498
Intropin
Intropin [*hydrochloride*]
KBio1_000780
 
KBio2_001492
KBio2_002388
KBio2_002484
KBio2_004060
KBio2_004956
KBio2_005052
KBio2_006628
KBio2_007524
KBio2_007620
KBio3_001152
KBio3_002867
KBio3_002962
KBioGR_001129
KBioGR_002388
KBioGR_002484
KBioSS_001492
KBioSS_002393
KBioSS_002491
KW-3-060
L-DOPAMINE
L000232
LDP
LS-159
Lopac-H-8502
Lopac0_000586
Medopa (TN)
MolPort-001-641-000
NCGC00015519-01
NCGC00015519-08
NCGC00096050-01
NCGC00096050-02
NCGC00096050-03
NCGC00096050-04
NCGC00096050-05
NINDS_000780
NSC 173182
NSC169105
NSC173182
Oprea1_088821
Oxytyramine
Pyrocatechol, 4-(2-aminoethyl)- (8CI)
Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
Revimine
Revivan
SPBio_001205
SPECTRUM1505155
ST048774
STK301601
Spectrum2_001023
Spectrum3_000406
Spectrum4_000525
Spectrum5_000945
Spectrum_001012
UNII-VTD58H1Z2X
UPCMLD0ENAT5885989:001
a-(3,4-Dihydroxyphenyl)-b-aminoethane
alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
cMAP_000036
cMAP_000065
dopamine
hydroxytyramine
intropin
m-Hydroxytyramine hydrochloride
nchembio.105-comp9
nchembio.107-comp4
nchembio.284-comp1
nchembio.78-comp16
nchembio.89-comp3
nchembio705-8
nchembio801-comp8
4
RivastigminePhase 382123441-03-277991
Synonyms:
(S)-3-(1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate
123441-03-2
3-((1S)-1-(Dimethylamino)ethyl)phenyl N-ethyl-N-methylcarbamate
3-((1S)-1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate
3-[(1S)-1-(dimethylamino)ethyl]phenyl ethyl(methyl)carbamate
AB1004572
AC1L2U92
BIDD:GT0316
C11766
CHEMBL636
CID77991
Carbamic acid, N-ethyl-N-methyl-, 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester
Carbamic acid, ethylmethyl-, 3-((1S)-1-(dimethylamino)ethyl)phenyl ester
D03822
DB00989
ENA 713 free base
 
Ena 713 Free Base
Ethylmethylcarbamic acid 3-((1S)-1-(dimethylamino)ethyl)phenyl ester
Exelon
Exelon Patch
HMS2089H18
I06-2037
LS-172571
MolPort-003-666-662
NCGC00167531-01
Rivastigmine (JAN/USAN/INN)
Rivastigmine Hydrogen Tartrate
Rivastigmine [USAN:INN]
Rivastigmine hydrogen tartrate
SDZ 212-713
UNII-PKI06M3IW0
[3-[(1S)-1-(dimethylamino)ethyl]phenyl] N-ethyl-N-methylcarbamate
m-((S)-1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate
rivastigmine

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study of (Mirapex) Pramipexole for the Early Treatment of Parkinsons Disease (PD)CompletedNCT00321854Phase 4
2Efficacy of RIVAstigmine on Motor, Cognitive and Behavioural Impairment in Progressive Supranuclear PalsyRecruitingNCT02839642Phase 3
3Development of a Novel 18F-DTBZ PET Imaging as a Biomarker to Monitor Neurodegeneration of PARK6 and PARK8 ParkinsonismCompletedNCT01759888Phase 2
4A Trial of MitoQ for the Treatment of People With Parkinson's DiseaseCompletedNCT00329056Phase 2
5Imaging and Genetic Biomarkers of Parkinson Disease (PD) Onset and Progression in High-risk FamiliesCompletedNCT00273351Phase 2
6Parkin Mutations and Their Functional ConsequencesActive, not recruitingNCT00136721Phase 1
7Functional Characterization of Parkin + PatientsTerminatedNCT00142311Phase 1
8Hereditary Parkinson s Disease Natural History ProtocolRecruitingNCT02511015
9Genetic Study in Young Onset Parkinson's DiseaseActive, not recruitingNCT01529970
10Early Parkinson's Disease (PD) Cross-SectionalTerminatedNCT00817453

Search NIH Clinical Center for Parkinson Disease 6, Early Onset

Genetic Tests for Parkinson Disease 6, Early Onset

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Genetic tests related to Parkinson Disease 6, Early Onset:

id Genetic test Affiliating Genes
1 Parkinson Disease 6, Autosomal Recessive Early-Onset25
2 Parkinson Disease 625
3 Parkinson Disease, Autosomal Recessive Early-Onset, Digenic, Pink1/dj125

Anatomical Context for Parkinson Disease 6, Early Onset

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Animal Models for Parkinson Disease 6, Early Onset or affiliated genes

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MGI Mouse Phenotypes related to Parkinson Disease 6, Early Onset:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.3ATP13A2, LRRK2, MT-ND6, PARK2, PARK7, PINK1
2MP:00036317.3ATP13A2, LRRK2, MT-ND6, PARK2, PARK7, PINK1

Publications for Parkinson Disease 6, Early Onset

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Variations for Parkinson Disease 6, Early Onset

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UniProtKB/Swiss-Prot genetic disease variations for Parkinson Disease 6, Early Onset:

68 (show all 22)
id Symbol AA change Variation ID SNP ID
1PINK1p.Gly309AspVAR_018994rs74315355
2PINK1p.Cys92PheVAR_046568
3PINK1p.Ala168ProVAR_046575rs768091663
4PINK1p.Pro196LeuVAR_046577rs138302371
5PINK1p.Ala217AspVAR_046578rs74315360
6PINK1p.Glu240LysVAR_046581rs573931674
7PINK1p.Leu268ValVAR_046584rs372280083
8PINK1p.His271GlnVAR_046585rs28940284
9PINK1p.Arg279HisVAR_046587rs74315358
10PINK1p.Thr313MetVAR_046589rs74315359
11PINK1p.Leu347ProVAR_046593rs28940285
12PINK1p.Cys388ArgVAR_046596
13PINK1p.Glu417GlyVAR_046599
14PINK1p.Arg464HisVAR_046605rs764328076
15PINK1p.Leu489ProVAR_046607
16PINK1p.Cys125GlyVAR_062773
17PINK1p.Ala280ThrVAR_062774rs772510148
18PINK1p.Leu369ProVAR_062775
19PINK1p.Gly386AlaVAR_062776
20PINK1p.Arg407GlnVAR_062778rs556540177
21PINK1p.Gly409ValVAR_062779
22PINK1p.Gln126ProVAR_064344

Clinvar genetic disease variations for Parkinson Disease 6, Early Onset:

5 (show all 15)
id Gene Variation Type Significance SNP ID Assembly Location
1PINK1NM_032409.2(PINK1): c.620delG (p.Arg207Glnfs)deletionPathogenicrs756677845GRCh38Chr 1, 20638074: 20638074
2NM_032409.2(PINK1): c.926G> A (p.Gly309Asp)single nucleotide variantPathogenicrs74315355GRCh37Chr 1, 20971132: 20971132
3NM_032409.2(PINK1): c.813C> A (p.His271Gln)single nucleotide variantPathogenicrs28940284GRCh37Chr 1, 20971019: 20971019
4NM_032409.2(PINK1): c.1311G> A (p.Trp437Ter)single nucleotide variantPathogenicrs74315356GRCh37Chr 1, 20975547: 20975547
5PINK1NM_032409.2(PINK1): c.736C> T (p.Arg246Ter)single nucleotide variantPathogenicrs74315357GRCh37Chr 1, 20966445: 20966445
6NM_032409.2(PINK1): c.1040T> C (p.Leu347Pro)single nucleotide variantPathogenicrs28940285GRCh37Chr 1, 20972133: 20972133
7NM_032409.2(PINK1): c.1570_1573dupTTAG (p.Asp525Valfs)duplicationPathogenicrs730880302GRCh37Chr 1, 20977008: 20977011
8PINK1PINK1, 3-BP INS, 1602CAAinsertionPathogenic
9NM_032409.2(PINK1): c.836G> A (p.Arg279His)single nucleotide variantPathogenicrs74315358GRCh37Chr 1, 20971042: 20971042
10NM_005216.4(DDOST): c.*807_*5409deldeletionPathogenicGRCh38Chr 1, 20646970: 20651572
11NM_032409.2(PINK1): c.938C> T (p.Thr313Met)single nucleotide variantPathogenicrs74315359GRCh37Chr 1, 20971144: 20971144
12PINK1NM_032409.2(PINK1): c.650C> A (p.Ala217Asp)single nucleotide variantPathogenicrs74315360GRCh37Chr 1, 20964597: 20964597
13NM_032409.2(PINK1): c.1366C> T (p.Gln456Ter)single nucleotide variantPathogenicrs45539432GRCh37Chr 1, 20975602: 20975602
14MT-ND6m.14319T> Csingle nucleotide variantrisk factorrs199476110GRCh37Chr MT, 14319: 14319
15MT-ND5m.12397A> Gsingle nucleotide variantrisk factorrs200890363GRCh37Chr MT, 12397: 12397

Expression for genes affiliated with Parkinson Disease 6, Early Onset

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Search GEO for disease gene expression data for Parkinson Disease 6, Early Onset.

Pathways for genes affiliated with Parkinson Disease 6, Early Onset

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GO Terms for genes affiliated with Parkinson Disease 6, Early Onset

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Cellular components related to Parkinson Disease 6, Early Onset according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Lewy bodyGO:009741310.4PARK2, PINK1
2mitochondrial respiratory chain complex IGO:000574710.3MT-ND5, PARK7
3ubiquitin ligase complexGO:00001519.6FBXO7, PARK2, PINK1
4presynapseGO:00987939.4PARK2, PARK7
5mitochondrial inner membraneGO:00057438.7LRRK2, MT-ND5, MT-ND6, PINK1
6axonGO:00304248.5LRRK2, PARK7, PINK1
7mitochondrionGO:00057397.8FBXO7, LRRK2, PARK2, PARK7, PINK1
8neuron projectionGO:00430057.6ATP13A2, LRRK2, MT-ND5, PARK2, PARK7

Biological processes related to Parkinson Disease 6, Early Onset according to GeneCards Suite gene sharing:

(show all 49)
idNameGO IDScoreTop Affiliating Genes
1cellular response to toxic substanceGO:009723710.4PARK2, PINK1
2positive regulation of mitochondrial electron transport, NADH to ubiquinoneGO:190295810.3PARK7, PINK1
3negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathwayGO:190338410.3PARK7, PINK1
4regulation of protein targeting to mitochondrionGO:190321410.3PARK2, PINK1
5mitochondrial respiratory chain complex I assemblyGO:003298110.2MT-ND5, MT-ND6
6negative regulation of oxidative stress-induced neuron deathGO:190320410.2PARK7, PINK1
7regulation of neuron apoptotic processGO:004352310.2PARK7, PINK1
8negative regulation of reactive oxygen species metabolic processGO:200037810.2PARK2, PINK1
9activation of protein kinase B activityGO:003214810.2PARK7, PINK1
10negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathwayGO:190337710.2PARK2, PARK7
11dopamine uptake involved in synaptic transmissionGO:005158310.2PARK2, PARK7
12negative regulation of JNK cascadeGO:004632910.2PARK2, PINK1
13regulation of protein ubiquitinationGO:003139610.1PARK2, PINK1
14regulation of reactive oxygen species metabolic processGO:200037710.1PARK2, PINK1
15mitochondrial electron transport, NADH to ubiquinoneGO:000612010.1MT-ND5, MT-ND6
16zinc ion homeostasisGO:005506910.0ATP13A2, PARK2
17negative regulation of cell deathGO:006054810.0PARK2, PARK7
18positive regulation of mitochondrial fissionGO:00901419.9PARK2, PINK1
19positive regulation of peptidyl-serine phosphorylationGO:00331389.9PARK7, PINK1
20negative regulation of autophagosome assemblyGO:19029029.9LRRK2, PINK1
21negative regulation of macroautophagyGO:00162429.9LRRK2, PINK1
22negative regulation of oxidative stress-induced cell deathGO:19032029.8PARK2, PARK7, PINK1
23negative regulation of hydrogen peroxide-induced cell deathGO:19032069.8LRRK2, PARK7
24mitophagyGO:00004229.7FBXO7, PARK2, PINK1
25positive regulation of protein ubiquitinationGO:00313989.7LRRK2, PINK1
26regulation of mitochondrial membrane potentialGO:00518819.7PARK2, PARK7, PINK1
27positive regulation of proteasomal ubiquitin-dependent protein catabolic processGO:00324369.7LRRK2, PARK2
28regulation of canonical Wnt signaling pathwayGO:00608289.6LRRK2, PARK2
29protein ubiquitinationGO:00165679.6FBXO7, PARK2, PINK1
30response to hydrogen peroxideGO:00425429.6MT-ND5, MT-ND6, PARK7
31regulation of synaptic vesicle transportGO:19028039.5LRRK2, PARK2, PINK1
32cellular response to dopamineGO:19033519.5LRRK2, PARK2
33negative regulation of protein bindingGO:00320919.5LRRK2, PARK7
34negative regulation of gene expressionGO:00106299.5PARK2, PARK7, PINK1
35synaptic transmission, dopaminergicGO:00019639.5PARK2, PARK7
36protein localization to mitochondrionGO:00705859.5LRRK2, PARK2
37protein stabilizationGO:00508219.4PARK2, PARK7, PINK1
38negative regulation of neuron apoptotic processGO:00435249.4PARK2, PARK7, PINK1
39regulation of mitochondrion organizationGO:00108219.3ATP13A2, PARK2, PINK1
40regulation of mitophagyGO:19031469.3ATP13A2, PARK2, PINK1
41regulation of autophagyGO:00105069.3LRRK2, PARK2
42response to oxidative stressGO:00069799.2LRRK2, PARK2, PINK1
43adult locomotory behaviorGO:00083449.2PARK2, PARK7
44cellular response to manganese ionGO:00712879.2ATP13A2, LRRK2, PARK2
45negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayGO:19022369.2LRRK2, PARK2, PARK7
46negative regulation of protein phosphorylationGO:00019338.9LRRK2, PARK2, PARK7
47mitochondrion organizationGO:00070058.7LRRK2, PARK2, PARK7, PINK1
48cellular response to oxidative stressGO:00345998.6ATP13A2, LRRK2, PARK7, PINK1
49negative regulation of neuron deathGO:19012158.5ATP13A2, LRRK2, PARK2, PARK7

Molecular functions related to Parkinson Disease 6, Early Onset according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1NADH dehydrogenase (ubiquinone) activityGO:00081379.9MT-ND5, MT-ND6
2cupric ion bindingGO:19031359.6ATP13A2, PARK7
3ubiquitin-specific protease bindingGO:19903819.5PARK2, PARK7
4tubulin bindingGO:00156318.9LRRK2, PARK2

Sources for Parkinson Disease 6, Early Onset

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet