PARK2
MCID: PRK024
MIFTS: 48

Parkinson Disease, Juvenile, Type 2 (PARK2) malady

Categories: Genetic diseases, Rare diseases, Neuronal diseases, Mental diseases, Metabolic diseases

Aliases & Classifications for Parkinson Disease, Juvenile, Type 2

Aliases & Descriptions for Parkinson Disease, Juvenile, Type 2:

Name: Parkinson Disease, Juvenile, Type 2 54 13
Parkinson Disease 2 50 66 29
Autosomal Recessive Juvenile Parkinson Disease 50 66
Early-Onset Parkinson Disease 50 56
Young-Onset Parkinson Disease 50 56
Park2 50 66
Pdj 50 66
Autosomal Recessive Early-Onset Parkinson Disease Type 2 66
Chromosome 6-Linked Autosomal Recessive Parkinsonism 66
Parkinsonism, Early Onset, with Diurnal Fluctuation 50
Parkinson Disease Autosomal Recessive, Early Onset 50
Early-Onset Parkinsonism with Diurnal Fluctuation 66
Parkinson Disease 2, Autosomal Recessive Juvenile 69
Autosomal Recessive Juvenile Parkinson Disease 2 12
Parkinsonism Young Adult Onset 66
Parkinsonism, Juvenile 69
Juvenile Parkinsonism 50
Yopd 56
Epdf 66
Jp 50

Characteristics:

Orphanet epidemiological data:

56
young-onset parkinson disease
Inheritance: Autosomal dominant,Autosomal recessive; Prevalence: 1-5/10000 (Europe); Age of onset: Adult; Age of death: elderly;

HPO:

32
parkinson disease, juvenile, type 2:
Inheritance autosomal recessive inheritance
Onset and clinical course adult onset


Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

OMIM 54 600116
Disease Ontology 12 DOID:0060368
Orphanet 56 ORPHA2828
ICD10 via Orphanet 34 G20
MedGen 40 C1868675
MeSH 42 D020734

Summaries for Parkinson Disease, Juvenile, Type 2

UniProtKB/Swiss-Prot : 66 Parkinson disease 2: A neurodegenerative disorder characterized by bradykinesia, rigidity, postural instability, tremor, and onset usually before 40. It differs from classic Parkinson disease by early DOPA-induced dyskinesia, diurnal fluctuation of the symptoms, sleep benefit, dystonia and hyper-reflexia. Dementia is absent. Pathologically, patients show loss of dopaminergic neurons in the substantia nigra, similar to that seen in Parkinson disease; however, Lewy bodies (intraneuronal accumulations of aggregated proteins) are absent.

MalaCards based summary : Parkinson Disease, Juvenile, Type 2, also known as parkinson disease 2, is related to parkinson disease 6, early onset and pink1 type of young-onset parkinson disease, and has symptoms including tremor, dystonia and bradykinesia. An important gene associated with Parkinson Disease, Juvenile, Type 2 is PRKN (Parkin RBR E3 Ubiquitin Protein Ligase), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Chks in Checkpoint Regulation. The drugs Bromocriptine and Dopamine have been mentioned in the context of this disorder. Related phenotypes are behavior/neurological and homeostasis/metabolism

Disease Ontology : 12 A Parkinson's disease that has material basis in mutation in the parkin gene (PARK2) on chromosome 6q25.2-q27.

Description from OMIM: 600116

Related Diseases for Parkinson Disease, Juvenile, Type 2

Diseases in the Parkinson Disease, Late-Onset family:

Parkinson Disease 7, Autosomal Recessive Early-Onset Parkinson Disease 6, Early Onset
Parkinson Disease 19, Juvenile-Onset Parkinson Disease 10
Parkinson Disease 16 Parkinson Disease 13
Parkinson Disease 11 Parkinson Disease 21
Parkinson Disease 18 Parkinson Disease 5
Parkinson Disease 4 Parkinson Disease 1
Parkinson Disease, Juvenile, Type 2 Parkinson Disease 8
Parkinson Disease 17 Parkinson Disease 20, Early-Onset
Parkinson Disease 15, Autosomal Recessive Parkinson Disease 14, Autosomal Recessive
Parkinson Disease 12 Juvenile Onset Parkinson Disease 19a
Juvenile-Onset Parkinson Disease Early-Onset Parkinson Disease
Lrrk2-Related Parkinson Disease Parkinson Disease Type 3
Parkinson Disease Type 9 Dnajc6-Related Parkinson Disease
Eif4g1-Related Parkinson Disease Gigyf2-Related Parkinson Disease
Pla2g6-Related Parkinson Disease Synj1-Related Parkinson Disease
Fbxo7-Related Parkinson Disease Htra2-Related Parkinson Disease
Park7-Related Parkinson Disease Snca-Related Parkinson Disease
Vps35-Related Parkinson Disease Hereditary Late-Onset Parkinson Disease
Parkinson Disease 22 Parkinson Disease 23, Autosomal Recessive, Early Onset

Diseases related to Parkinson Disease, Juvenile, Type 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
id Related Disease Score Top Affiliating Genes
1 parkinson disease 6, early onset 32.2 LRRK2 PARK7 PINK1
2 pink1 type of young-onset parkinson disease 12.3
3 early-onset parkinson disease 12.3
4 parkin type of early-onset parkinson disease 12.3
5 polyposis, juvenile intestinal 11.8
6 atypical juvenile parkinsonism 11.8
7 parkinson disease 20, early-onset 11.7
8 juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome 11.6
9 parkinson disease 7, autosomal recessive early-onset 11.3
10 parkinson disease 23, autosomal recessive, early onset 11.2
11 parkinson disease 15, autosomal recessive 11.2
12 waisman syndrome 11.0
13 parkinson disease, late-onset 10.9
14 autosomal recessive early-onset parksinson disease 23 10.9
15 rubinstein-taybi syndrome 2 10.1 PINK1 PRKN
16 kufor-rakeb syndrome 10.0 PARK7 PINK1
17 cerebral atrophy 9.9 SNCA UCHL1
18 transient neonatal myasthenia gravis 9.9 LRRK2 SNCA
19 riedel's fibrosing thyroiditis 9.8 LRRK2 SNCA
20 meier-gorlin syndrome 5 9.8 LRRK2 PARK7 SNCA
21 lower gum cancer 9.8 LRRK2 SNCA
22 nephrotic syndrome 9.8
23 lynch syndrome 9.8
24 biliary dyskinesia 9.8
25 rem sleep behavior disorder 9.8
26 colorectal cancer 9.8
27 intellectual disability 9.7
28 multiple system atrophy 9.7 PARK7 PINK1 SNCA UCHL1
29 lethal congenital contracture syndrome 8 9.7 LRRK2 PARK7 PINK1 SNCA
30 epithelioid type angiomyolipoma 9.7 LRRK2 PINK1 SNCA
31 cardiomyopathy, dilated, 1u 9.7 LRRK2 PRKN SNCA
32 thrombosis 9.7 LRRK2 PARK7 PINK1 SNCA
33 benign partial epilepsy with secondarily generalized seizures in infancy 9.7 HTRA2 LRRK2 SNCA
34 substance-induced psychosis 9.7 LRRK2 PARK7 PINK1 SNCA
35 thyrotropin-releasing hormone deficiency 9.7 HTRA2 LRRK2 SNCA
36 plekhm1-related autosomal recessive osteopetrosis 9.6 LRRK2 PARK7 SNCA UCHL1
37 spink1-related hereditary pancreatitis 9.6 LRRK2 PARK7 PRKN SNCA
38 coenzyme q10 deficiency, primary, 1 9.6 LRRK2 PARK7 PRKN SNCA
39 ceroid lipofuscinosis, neuronal, 1 9.5 LRRK2 PARK7 PINK1 PRKN SNCA
40 klippel-feil syndrome 4, autosomal recessive, with myopathy and facial dysmorphism 9.5 LRRK2 PARK7 PINK1 PRKN SNCA
41 hypoproteinemia, hypercatabolic 9.5 LRRK2 PARK7 PINK1 PRKN SNCA
42 cavernous hemangioma 9.5 LRRK2 PARK7 PINK1 PRKN SNCA
43 gallbladder adenoma 9.5 LRRK2 PARK7 PINK1 PRKN SNCA
44 hemochromatosis, type 2a 9.2 LRRK2 PARK7 PINK1 PRKN SNCA UCHL1
45 trichothiodystrophy 3, photosensitive 8.7 DNAJC6 HTRA2 LRRK2 PARK7 PINK1 PODXL

Graphical network of the top 20 diseases related to Parkinson Disease, Juvenile, Type 2:



Diseases related to Parkinson Disease, Juvenile, Type 2

Symptoms & Phenotypes for Parkinson Disease, Juvenile, Type 2

Symptoms by clinical synopsis from OMIM:

600116

Clinical features from OMIM:

600116

Human phenotypes related to Parkinson Disease, Juvenile, Type 2:

32 (show all 9)
id Description HPO Frequency HPO Source Accession
1 tremor 32 HP:0001337
2 dystonia 32 HP:0001332
3 bradykinesia 32 HP:0002067
4 gait disturbance 32 HP:0001288
5 hyperreflexia 32 HP:0001347
6 rigidity 32 HP:0002063
7 parkinsonism 32 HP:0001300
8 postural instability 32 HP:0002172
9 substantia nigra gliosis 32 HP:0011960

UMLS symptoms related to Parkinson Disease, Juvenile, Type 2:


muscle rigidity, tremor, bradykinesia

MGI Mouse Phenotypes related to Parkinson Disease, Juvenile, Type 2:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.7 HTRA2 LRRK2 PARK7 PINK1 PRKN SNCA
2 homeostasis/metabolism MP:0005376 9.56 HTRA2 LRRK2 PARK7 PINK1 PRKN SNCA
3 nervous system MP:0003631 9.23 DNAJC6 HTRA2 LRRK2 PARK7 PINK1 PRKN

Drugs & Therapeutics for Parkinson Disease, Juvenile, Type 2

Drugs for Parkinson Disease, Juvenile, Type 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bromocriptine Approved, Investigational Phase 2 25614-03-3 31101
2
Dopamine Approved Phase 2 51-61-6, 62-31-7 681
3 Antiparkinson Agents Phase 2
4 Dopamine Agents Phase 2
5 Dopamine agonists Phase 2
6 Hormone Antagonists Phase 2
7 Hormones Phase 2
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
9 Neurotransmitter Agents Phase 2
10 insulin
11 Insulin, Globin Zinc

Interventional clinical trials:


id Name Status NCT ID Phase
1 Bromocriptine Quick Release (BCQR) as Adjunct Therapy in Type 1 Diabetes Recruiting NCT02544321 Phase 2
2 Consortium On Risk for Early-onset Parkinson's Disease (CORE PD) Unknown status NCT00104585
3 Genetic Study in Young Onset Parkinson's Disease Unknown status NCT01529970
4 Mutations Associated With Parkinson s Disease Completed NCT01547832
5 Hereditary Parkinson s Disease Natural History Protocol Recruiting NCT02511015
6 Parkinson's Families Project Recruiting NCT02760108
7 To Evaluate the Safety and Efficacy of Remsima™ in Patients With Crohn's Disease (CD) or Ulcerative Colitis (UC) Recruiting NCT02326155
8 Proof of Concept BeatPark Not yet recruiting NCT02647242

Search NIH Clinical Center for Parkinson Disease, Juvenile, Type 2

Genetic Tests for Parkinson Disease, Juvenile, Type 2

Genetic tests related to Parkinson Disease, Juvenile, Type 2:

id Genetic test Affiliating Genes
1 Parkinson Disease 2 29

Anatomical Context for Parkinson Disease, Juvenile, Type 2

Publications for Parkinson Disease, Juvenile, Type 2

Variations for Parkinson Disease, Juvenile, Type 2

UniProtKB/Swiss-Prot genetic disease variations for Parkinson Disease, Juvenile, Type 2:

66 (show all 26)
id Symbol AA change Variation ID SNP ID
1 PRKN p.Val15Met VAR_019733 rs532703934
2 PRKN p.Arg33Gln VAR_019734 rs147757966
3 PRKN p.Pro37Leu VAR_019735 rs148990138
4 PRKN p.Arg42Pro VAR_019736 rs368134308
5 PRKN p.Ala46Pro VAR_019737
6 PRKN p.Ala82Glu VAR_019738 rs55774500
7 PRKN p.Ala92Val VAR_019739 rs566229879
8 PRKN p.Lys161Asn VAR_019741 rs137853057
9 PRKN p.Lys211Asn VAR_019744 rs137853060
10 PRKN p.Cys212Tyr VAR_019746 rs137853058
11 PRKN p.Thr240Met VAR_019747 rs137853054
12 PRKN p.Thr240Arg VAR_019748 rs137853054
13 PRKN p.Arg256Cys VAR_019750 rs150562946
14 PRKN p.Arg275Trp VAR_019752 rs34424986
15 PRKN p.Gly284Arg VAR_019754 rs751037529
16 PRKN p.Cys289Gly VAR_019755 rs55961220
17 PRKN p.Gly328Glu VAR_019756
18 PRKN p.Thr351Pro VAR_019759
19 PRKN p.Thr415Asn VAR_019763 rs778125254
20 PRKN p.Gly430Asp VAR_019764 rs191486604
21 PRKN p.Cys431Phe VAR_019765 rs397514694
22 PRKN p.Pro437Leu VAR_019766 rs149953814
23 PRKN p.Cys441Arg VAR_019767 rs778305273
24 PRKN p.Val56Glu VAR_070078 rs137853059
25 PRKN p.Arg402Cys VAR_070079 rs55830907
26 PRKN p.Cys418Arg VAR_070080

ClinVar genetic disease variations for Parkinson Disease, Juvenile, Type 2:

6 (show all 22)
id Gene Variation Type Significance SNP ID Assembly Location
1 PRKN NM_004562.2(PRKN): c.1358G> A (p.Trp453Ter) single nucleotide variant Pathogenic rs137853056 GRCh37 Chromosome 6, 161771171: 161771171
2 PRKN NM_004562.2(PRKN): c.872-?_1083+?del deletion Pathogenic GRCh38 Chromosome 6, 161548854: 161569416
3 PRKN NM_004562.2(PRKN): c.172-?_871+?del deletion Pathogenic GRCh37 Chromosome 6, 162206804: 162683797
4 PRKN NM_004562.2(PRKN): c.413-?_534+?del deletion Pathogenic GRCh37 Chromosome 6, 162622163: 162622284
5 PRKN NM_004562.2(PRKN): c.719C> G (p.Thr240Arg) single nucleotide variant Pathogenic rs137853054 GRCh37 Chromosome 6, 162394349: 162394349
6 PRKN NM_004562.2(PRKN): c.931C> T (p.Gln311Ter) single nucleotide variant Pathogenic rs137853055 GRCh37 Chromosome 6, 161990389: 161990389
7 PRKN NM_004562.2(PRKN): c.8-?_171+?del deletion Pathogenic GRCh37 Chromosome 6, 162864342: 162864505
8 PRKN NM_004562.2(PRKN): c.483A> T (p.Lys161Asn) single nucleotide variant Pathogenic rs137853057 GRCh37 Chromosome 6, 162622214: 162622214
9 PRKN PARK2, 1-BP DEL, 202A deletion Pathogenic
10 PRKN NM_004562.2(PRKN): c.735-?_871+?del deletion Pathogenic GRCh37 Chromosome 6, 162206804: 162206940
11 PRKN NM_004562.2(PRKN): c.635G> A (p.Cys212Tyr) single nucleotide variant Pathogenic rs137853058 GRCh37 Chromosome 6, 162394433: 162394433
12 PRKN NM_004562.2(PRKN): c.167T> A (p.Val56Glu) single nucleotide variant Pathogenic rs137853059 GRCh37 Chromosome 6, 162864346: 162864346
13 PRKN PARK2, 1-BP DEL, 255A deletion Pathogenic
14 PRKN NM_004562.2(PRKN): c.633A> T (p.Lys211Asn) single nucleotide variant Pathogenic rs137853060 GRCh37 Chromosome 6, 162394435: 162394435
15 PRKN PARK2, 1-BP DEL, 1072T deletion Pathogenic
16 PRKN NM_004562.2(PRKN): c.7+1G> T single nucleotide variant Pathogenic rs397518439 GRCh37 Chromosome 6, 163148693: 163148693
17 PRKN PARK2, EX5-6 DEL deletion Pathogenic
18 PRKN NM_004562.2(PRKN): c.1292G> T (p.Cys431Phe) single nucleotide variant Pathogenic rs397514694 GRCh37 Chromosome 6, 161771237: 161771237
19 PODXL NM_005397.3(PODXL): c.89_90insGTCGCCCC (p.Gln32Profs) insertion Likely pathogenic rs759639123 GRCh37 Chromosome 7, 131241029: 131241030
20 PRKN NC_000006.12: g.(?_162054091)_(162054174_?)del deletion Pathogenic GRCh37 Chromosome 6, 162475123: 162475206
21 PRKN NM_004562.2(PRKN): c.850G> C (p.Gly284Arg) single nucleotide variant Pathogenic rs751037529 GRCh38 Chromosome 6, 161785793: 161785793
22 PRKN NC_000006.12: g.(?_162201131)_(162443473_?)del deletion Pathogenic GRCh37 Chromosome 6, 162622163: 162864505

Expression for Parkinson Disease, Juvenile, Type 2

Search GEO for disease gene expression data for Parkinson Disease, Juvenile, Type 2.

Pathways for Parkinson Disease, Juvenile, Type 2

GO Terms for Parkinson Disease, Juvenile, Type 2

Cellular components related to Parkinson Disease, Juvenile, Type 2 according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.91 HTRA2 LRRK2 PARK7 PRKN UCHL1
2 perinuclear region of cytoplasm GO:0048471 9.8 PARK7 PINK1 PRKN SNCA
3 membrane raft GO:0045121 9.65 LRRK2 PARK7 PODXL
4 mitochondrial outer membrane GO:0005741 9.63 LRRK2 PINK1 VPS13C
5 chromatin GO:0000785 9.58 HTRA2 PARK7 PINK1
6 mitochondrial respiratory chain complex I GO:0005747 9.54 PARK7 SNCA
7 postsynapse GO:0098794 9.52 LRRK2 SNCA
8 cell body GO:0044297 9.5 PARK7 PINK1 PODXL
9 mitochondrion GO:0005739 9.5 HTRA2 LRRK2 PARK7 PINK1 PRKN SNCA
10 inclusion body GO:0016234 9.43 LRRK2 SNCA
11 mitochondrial intermembrane space GO:0005758 9.43 HTRA2 PARK7 PINK1
12 Lewy body GO:0097413 9.16 PINK1 PRKN
13 axon GO:0030424 9.02 LRRK2 PARK7 PINK1 SNCA UCHL1
14 cytosol GO:0005829 10.02 DNAJC6 HTRA2 LRRK2 PARK7 PINK1 PRKN

Biological processes related to Parkinson Disease, Juvenile, Type 2 according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.88 PARK7 PINK1 PRKN
2 protein stabilization GO:0050821 9.86 PARK7 PINK1 PRKN
3 autophagy GO:0006914 9.86 LRRK2 PARK7 PINK1 PRKN
4 response to oxidative stress GO:0006979 9.85 LRRK2 PINK1 PRKN
5 negative regulation of neuron apoptotic process GO:0043524 9.81 PARK7 PINK1 PRKN SNCA
6 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.79 PARK7 PINK1 SNCA
7 negative regulation of cell death GO:0060548 9.77 HTRA2 PARK7 PRKN
8 negative regulation of protein phosphorylation GO:0001933 9.73 LRRK2 PARK7 PRKN SNCA
9 protein destabilization GO:0031648 9.71 PRKN SNCA
10 adult walking behavior GO:0007628 9.71 HTRA2 UCHL1
11 regulation of mitophagy GO:1903146 9.71 HTRA2 PINK1
12 mitophagy GO:0000422 9.71 PINK1 PRKN
13 activation of protein kinase B activity GO:0032148 9.71 PARK7 PINK1
14 adult locomotory behavior GO:0008344 9.71 HTRA2 PARK7 PRKN SNCA
15 regulation of canonical Wnt signaling pathway GO:0060828 9.7 LRRK2 PRKN
16 negative regulation of JNK cascade GO:0046329 9.7 PINK1 PRKN
17 regulation of neuron apoptotic process GO:0043523 9.7 PARK7 PINK1
18 regulation of mitochondrial membrane potential GO:0051881 9.7 PARK7 PINK1 PRKN
19 negative regulation of reactive oxygen species metabolic process GO:2000378 9.69 PINK1 PRKN
20 regulation of dopamine secretion GO:0014059 9.69 PRKN SNCA
21 regulation of neuron death GO:1901214 9.69 LRRK2 SNCA
22 cellular protein catabolic process GO:0044257 9.68 HTRA2 PRKN
23 regulation of neurotransmitter secretion GO:0046928 9.68 PRKN SNCA
24 regulation of protein ubiquitination GO:0031396 9.67 PINK1 PRKN
25 positive regulation of mitochondrial fission GO:0090141 9.67 PINK1 PRKN
26 cellular response to dopamine GO:1903351 9.67 LRRK2 PRKN
27 regulation of reactive oxygen species metabolic process GO:2000377 9.67 PINK1 PRKN SNCA
28 regulation of mitochondrion organization GO:0010821 9.66 PINK1 PRKN
29 dopamine metabolic process GO:0042417 9.66 PRKN SNCA
30 negative regulation of macroautophagy GO:0016242 9.65 LRRK2 PINK1
31 negative regulation of oxidative stress-induced neuron death GO:1903204 9.65 PARK7 PINK1
32 negative regulation of autophagosome assembly GO:1902902 9.65 LRRK2 PINK1
33 synaptic transmission, dopaminergic GO:0001963 9.65 PARK7 PRKN SNCA
34 mitophagy in response to mitochondrial depolarization GO:0098779 9.64 PINK1 PRKN
35 negative regulation of hydrogen peroxide-induced cell death GO:1903206 9.64 LRRK2 PARK7
36 positive regulation of mitophagy GO:1903599 9.63 PARK7 PRKN
37 regulation of locomotion GO:0040012 9.63 LRRK2 SNCA
38 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 9.63 LRRK2 PARK7 PRKN
39 cellular response to toxic substance GO:0097237 9.62 PINK1 PRKN
40 regulation of protein targeting to mitochondrion GO:1903214 9.62 PINK1 PRKN
41 protein localization to mitochondrion GO:0070585 9.61 LRRK2 PRKN
42 cellular response to manganese ion GO:0071287 9.6 LRRK2 PRKN
43 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903377 9.58 PARK7 PRKN
44 regulation of cellular response to oxidative stress GO:1900407 9.58 PINK1 PRKN
45 mitochondrion to lysosome transport GO:0099074 9.57 PINK1 PRKN
46 negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway GO:1903384 9.55 PARK7 PINK1
47 cellular response to oxidative stress GO:0034599 9.55 HTRA2 LRRK2 PARK7 PINK1 SNCA
48 positive regulation of mitochondrial electron transport, NADH to ubiquinone GO:1902958 9.54 PARK7 PINK1
49 dopamine uptake involved in synaptic transmission GO:0051583 9.54 PARK7 PRKN SNCA
50 regulation of synaptic vesicle transport GO:1902803 9.5 LRRK2 PINK1 PRKN

Molecular functions related to Parkinson Disease, Juvenile, Type 2 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 tubulin binding GO:0015631 9.37 LRRK2 PRKN
2 identical protein binding GO:0042802 9.35 HTRA2 LRRK2 PARK7 PRKN SNCA
3 Hsp70 protein binding GO:0030544 9.32 PRKN SNCA
4 phospholipase binding GO:0043274 9.26 PRKN SNCA
5 ubiquitin-specific protease binding GO:1990381 9.16 PARK7 PRKN
6 cuprous ion binding GO:1903136 8.62 PARK7 SNCA

Sources for Parkinson Disease, Juvenile, Type 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....