MCID: PRK057
MIFTS: 28

Parkinson Disease, Late-Onset malady

Genetic diseases, Mental diseases, Rare diseases, Neuronal diseases, Eye diseases categories
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Summaries for Parkinson Disease, Late-Onset

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47OMIM, 33MalaCards
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MalaCards: Parkinson Disease, Late-Onset, also known as parkinson-dementia syndrome, is related to parkinson's disease and wolff-parkinson-white syndrome. An important gene associated with Parkinson Disease, Late-Onset is GBA (glucosidase, beta, acid). The compounds colchicine and asparagine have been mentioned in the context of this disorder. Related mouse phenotypes are integument and respiratory system.

Description from OMIM:47 168600

Aliases & Classifications for Parkinson Disease, Late-Onset

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Sources:
47OMIM, 62UMLS, 25ICD10
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Classifications:



Aliases & Descriptions:

parkinson disease, late-onset 47
parkinson-dementia syndrome 62


External Ids:

ICD1025 F02.3

Related Diseases for Parkinson Disease, Late-Onset

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of diseases related to Parkinson Disease, Late-Onset:



Diseases related to parkinson disease, late-onset

Symptoms for Parkinson Disease, Late-Onset

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47OMIM
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Symptoms by clinical synopsis from OMIM:

168600

Clinical features from OMIM:

168600

Drugs & Therapeutics for Parkinson Disease, Late-Onset

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Parkinson Disease, Late-Onset

Search NIH Clinical Center for Parkinson Disease, Late-Onset

Genetic Tests for Parkinson Disease, Late-Onset

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Anatomical Context for Parkinson Disease, Late-Onset

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Animal Models for Parkinson Disease, Late-Onset or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Parkinson Disease, Late-Onset:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.1PARK2, GBA
2MP:00053889.0PARK2, GBA
3MP:00053908.8PARK2, GBA

Publications for Parkinson Disease, Late-Onset

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Variations for Parkinson Disease, Late-Onset

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Sources:
64UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 7dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Parkinson Disease, Late-Onset:

64
id Symbol AA change Variation ID SNP ID
1PARK2p.Cys253TyrVAR_019749
2PARK2p.Arg256CysVAR_019750rs150562946
3PARK2p.Arg275TrpVAR_019752rs34424986
4PARK2p.Asp280AsnVAR_019753

Clinvar genetic disease variations for Parkinson Disease, Late-Onset:

1
id Gene Name Type Significance SNP ID Assembly Location
1MC1RNM_002386.3(MC1R): c.451C> T (p.Arg151Cys)single nucleotide variantPathogenic, risk factorrs1805007GRCh37Chr 16, 89986117: 89986117
2GLUD2NM_012084.3(GLUD2): c.1492T> G (p.Ser498Ala)single nucleotide variantPathogenicrs9697983GRCh37Chr X, 120183030: 120183030
3GBANM_001005741.2(GBA): c.1448T> C (p.Leu483Pro)single nucleotide variantPathogenic, risk factorrs421016GRCh37Chr 1, 155205043: 155205043
4GBANM_001005741.2(GBA): c.1226A> G (p.Asn409Ser)single nucleotide variantPathogenic, risk factorrs76763715GRCh37Chr 1, 155205634: 155205634
5GBANM_001005741.2(GBA): c.1504C> T (p.Arg502Cys)single nucleotide variantPathogenic, risk factorrs80356771GRCh37Chr 1, 155204987: 155204987
6GBANM_001005741.2(GBA): c.1448T> C (p.Leu483Pro)single nucleotide variantPathogenic, risk factorrs421016GRCh37Chr 1, 155205043: 155205043
7DNAJC13NM_015268.3(DNAJC13): c.2564A> G (p.Asn855Ser)single nucleotide variantPathogenicrs387907571GRCh37Chr 3, 132196839: 132196839
8MT-ND1m.3397A> Gsingle nucleotide variantPathogenicrs199476120GRCh37Chr MT, 3397: 3397

Expression for genes affiliated with Parkinson Disease, Late-Onset

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Parkinson Disease, Late-Onset

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Pathways for genes affiliated with Parkinson Disease, Late-Onset

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Compounds for genes affiliated with Parkinson Disease, Late-Onset

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Sources:
45Novoseek, 61Tocris Bioscience, 3BitterDB, 29IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Parkinson Disease, Late-Onset according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1colchicine45 61 3 29 1113.4PARK2, GBA
2asparagine459.4PARK2, GBA
3ceramide459.3GBA, PARK2
4proline459.3PARK2, GBA
5leucine459.3PARK2, GBA
6steroid459.2GBA, PARK2
7nitric oxide45 24 1111.2PARK2, GBA
8oxygen45 2410.1PARK2, GBA
9lipid459.1PARK2, GBA
10cysteine459.0GBA, PARK2
11glucose458.8PARK2, GBA

GO Terms for genes affiliated with Parkinson Disease, Late-Onset

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Sources:
16Gene Ontology
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Biological processes related to Parkinson Disease, Late-Onset according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell deathGO:0082199.1PARK2, GBA

Products for genes affiliated with Parkinson Disease, Late-Onset

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  • Antibodies
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Sources for Parkinson Disease, Late-Onset

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet