MCID: PRK057
MIFTS: 63

Parkinson Disease, Late-Onset malady

Genetic diseases, Rare diseases, Neuronal diseases, Metabolic diseases, Cancer diseases, Cardiovascular diseases, Mental diseases categories

Aliases & Classifications for Parkinson Disease, Late-Onset

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Parkinson Disease, Late-Onset, Aliases & Descriptions:

Name: Parkinson Disease, Late-Onset 45 30
Parkinson's Disease 30 9 41 20 21 42 32
Parkinson Disease 45 9 19 41 21 43 60
Kufor-Rakeb Syndrome 9 60
Primary Parkinsonism 41 21
 
Parkinsons Disease 11 22
Paralysis Agitans 9 41
Parkinson Disease, Late-Onset, Susceptibility to 10
Shaking Palsy 41
Pd 21


Classifications:



External Ids:

OMIM45 168600
Disease Ontology9 DOID:14330
NCIt38 C26845
MeSH33 D010300
ICD9CM27 332, 332.0
ICD1025 G20

Summaries for Parkinson Disease, Late-Onset

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OMIM:45 Parkinson disease was first described by James Parkinson in 1817. It is the second most common neurodegenerative... (168600) more...

MalaCards based summary: Parkinson Disease, Late-Onset, also known as parkinson's disease, is related to multiple system atrophy and parkinson disease type 3, and has symptoms including hallucinations, dysautonomia and urinary urgency. An important gene associated with Parkinson Disease, Late-Onset is TBP (TATA box binding protein), and among its related pathways is Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs amantadine and trihexyphenidyl hydrochloride and the compounds tmao and phosphocellulose have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related mouse phenotypes are no phenotypic analysis and behavior/neurological.

Disease Ontology:9 A synucleinopathy that has material basis in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.

Genetics Home Reference:21 Parkinson disease is a progressive disorder of the nervous system. The disorder affects several regions of the brain, especially an area called the substantia nigra that controls balance and movement.

NIH Rare Diseases:41 Parkinson disease belongs to a group of conditions called movement disorders. the four main symptoms are tremor, or trembling in hands, arms, legs, jaw, or head; rigidity, or stiffness of the limbs and trunk; bradykinesia, or slowness of movement; and postural instability, or impaired balance. these symptoms usually begin gradually and worsen with time.  as they become more pronounced, patients may have difficulty walking, talking, or completing other simple tasks.  not everyone with one or more of these symptoms has parkinson disease, as the symptoms sometimes appear in other diseases as well. parkinson disease affects about 1 to 2 percent of people over the age of 60 years and the chance of developing parkinson disease increases as we age. although some parkinson disease cases appear to be hereditary, and a few can be traced to specific genetic mutations, most cases are sporadic and occur in people with no apparent history of the disorder in their family.  many researchers now believe that parkinson disease results from a combination of genetic susceptibility and exposure to one or more environmental factors that trigger the disease.  last updated: 10/3/2011

MedlinePlus:32 Parkinson's disease (pd) is a type of movement disorder. it happens when nerve cells in the brain don't produce enough of a brain chemical called dopamine. sometimes it is genetic, but most cases do not seem to run in families. exposure to chemicals in the environment might play a role. symptoms begin gradually, often on one side of the body. later they affect both sides. they include trembling of hands, arms, legs, jaw and face stiffness of the arms, legs and trunk slowness of movement poor balance and coordination as symptoms get worse, people with the disease may have trouble walking, talking, or doing simple tasks. they may also have problems such as depression, sleep problems, or trouble chewing, swallowing, or speaking. there is no lab test for pd, so it can be difficult to diagnose. doctors use a medical history and a neurological examination to diagnose it. pd usually begins around age 60, but it can start earlier. it is more common in men than in women. there is no cure for pd. a variety of medicines sometimes help symptoms dramatically. surgery and deep brain stimulation (dbs) can help severe cases. with dbs, electrodes are surgically implanted in the brain. they send electrical pulses to stimulate the parts of the brain that control movement. nih: national institute of neurological disorders and stroke

NINDS:42 Parkinson's disease (PD) belongs to a group of conditions called motor system disorders, which are the result of the loss of dopamine-producing brain cells. The four primary symptoms of PD are tremor, or trembling in hands, arms, legs, jaw, and face; rigidity, or stiffness of the limbs and trunk; bradykinesia, or slowness of movement; and postural instability, or impaired balance and coordination. As these symptoms become more pronounced, patients may have difficulty walking, talking, or completing other simple tasks. PD usually affects people over the age of 60.

Wikipedia:63 Parkinson\'s disease (PD, also known as idiopathic or primary parkinsonism, hypokinetic rigid syndrome... more...

GeneReviews summary for parkinson-overview

Related Diseases for Parkinson Disease, Late-Onset

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Diseases in the Secondary Parkinson Disease family:

Parkinson Disease 7, Autosomal Recessive Early-Onset Parkinson Disease 19, Juvenile-Onset
Parkinson Disease 10 parkinson disease, late-onset
Parkinson Disease 16 Parkinson Disease 18
Parkinson Disease 17 Parkinson Disease 20, Early-Onset
Parkinson Disease 12 Parkinson Disease 13
Parkinson Disease 11 Parkinson Disease 5
Parkinson Disease 4 Parkinson Disease 1
Parkinson Disease 8 Parkinson Disease 15, Autosomal Recessive
Parkinson Disease 14 Parkinson Disease 6, Early Onset
Parkinson Disease, Juvenile, Type 2 Lrrk2-Related Parkinson Disease
Parkinson Disease Type 3 Parkinson Disease Type 9
Park7-Related Parkinson Disease Snca-Related Parkinson Disease
Htra2-Related Parkinson Disease Vps35-Related Parkinson Disease
Fbxo7-Related Parkinson Disease

Diseases related to Parkinson Disease, Late-Onset via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 176)
idRelated DiseaseScoreTop Affiliating Genes
1multiple system atrophy30.7MAPT, PARK2
2parkinson disease type 330.6MAPT, PARK2
3dementia30.6TBP, MAPT, PARK2, GBA
4alzheimer disease30.5PARK2, MAPT, TBP
5spinocerebellar ataxia30.2TBP, MAPT
6hydrocephalus30.1MAPT, GBA
7huntington disease30.1TBP, MAPT
8alcohol dependence30.0MAPT, ADH1C
9dementia, lewy body29.9PARK2, MAPT
10tauopathy29.9MAPT, PARK2
11pendred syndrome10.5
12parkinson disease, juvenile, type 210.5
13pathological gambling10.5
14essential tremor10.4
15tremor10.4
16pancreas disease10.4
17peritonitis10.4
18rem sleep behavior disorder10.4
19neurodegeneration with brain iron accumulation 110.4
20neuronitis10.4
21parkinson disease 1810.3
22parkinson disease 1710.3
23lrrk2-related parkinson disease10.3
24parkinson disease 1010.3
25parkinson disease 110.3
26parkinson disease 15, autosomal recessive10.3
27parkinson disease 6, early onset10.3
28prolidase deficiency10.3
29parkinson disease 1310.3
30parkinson disease 1110.3
31parkinson disease 510.3
32parkinson disease 810.3
33parkinson disease 1410.3
34apraxia10.3
35pink1 type of young-onset parkinson disease10.3
36progressive muscular atrophy10.2
37muscular atrophy10.2
38focal dystonia10.2PARK2
39parkinson disease 1610.2
40parkinson disease 410.2
41lateral sclerosis10.2
42cerebritis10.2
43postencephalitic parkinson disease10.2
44parkin type of early-onset parkinson disease10.2
45parkinson disease type 910.2
46epilepsy, pyridoxine-dependent10.2
47thyroiditis10.2
48parkinson disease 7, autosomal recessive early-onset10.2
49parkinson disease 19, juvenile-onset10.2
50parkinson disease 20, early-onset10.2

Graphical network of the top 20 diseases related to Parkinson Disease, Late-Onset:



Diseases related to parkinson disease, late-onset

Symptoms for Parkinson Disease, Late-Onset

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Symptoms by clinical synopsis from OMIM:

168600

Clinical features from OMIM:

168600

HPO human phenotypes related to Parkinson Disease, Late-Onset:

(show all 24)
id Description Frequency HPO Source Accession
1 hallucinations occasional (7.5%) HP:0000738
2 dysautonomia occasional (7.5%) HP:0002459
3 urinary urgency HP:0000012
4 mask-like facies HP:0000298
5 depression HP:0000716
6 dementia HP:0000726
7 personality changes HP:0000751
8 dysarthria HP:0001260
9 parkinsonism HP:0001300
10 dystonia HP:0001332
11 weak voice HP:0001621
12 dysphagia HP:0002015
13 constipation HP:0002019
14 rigidity HP:0002063
15 bradykinesia HP:0002067
16 postural instability HP:0002172
17 resting tremor HP:0002322
18 sleep disturbance HP:0002360
19 neuronal loss in central nervous system HP:0002529
20 insidious onset HP:0003587
21 progressive disorder HP:0003676
22 short stepped shuffling gait HP:0007311
23 substantia nigra gliosis HP:0011960
24 lewy bodies HP:0100315

Drugs & Therapeutics for Parkinson Disease, Late-Onset

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Drug clinical trials:

Search ClinicalTrials for Parkinson Disease, Late-Onset

Search NIH Clinical Center for Parkinson Disease, Late-Onset

Inferred drug relations via UMLS60/NDF-RT39:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Parkinson Disease, Late-Onset cell therapies at LifeMap Discovery.

Genetic Tests for Parkinson Disease, Late-Onset

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Genetic tests related to Parkinson Disease, Late-Onset:

id Genetic test Affiliating Genes
1 Parkinson Disease20 VPS35
2 Parkinson Disease, Susceptibility to20 MT-TT
3 Parkinson Disease Multi-Gene Panels20
4 Parkinson's Disease22

Anatomical Context for Parkinson Disease, Late-Onset

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MalaCards organs/tissues related to Parkinson Disease, Late-Onset:

31
Brain, Testes, Bone

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Parkinson Disease, Late-Onset:
id TissueAnatomical CompartmentCell Relevance
1 BrainSubstantia Nigra pars CompactaAdult Dopaminergic Neurons Potential therapeutic candidate, affected by disease
2 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
3 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Parkinson Disease, Late-Onset or affiliated genes

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MGI Mouse Phenotypes related to Parkinson Disease, Late-Onset:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.3TBP, MAPT, PARK2, MC1R
2MP:00053867.8MC1R, GBA, PARK2, MAPT, VPS35
3MP:00053787.7MC1R, ADH1C, MAPT, TBP, PARK2, GBA
4MP:00107687.5GBA, MAPT, ADH1C, PARK2, TBP, VPS35

Publications for Parkinson Disease, Late-Onset

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Variations for Parkinson Disease, Late-Onset

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UniProtKB/Swiss-Prot genetic disease variations for Parkinson Disease, Late-Onset:

62
id Symbol AA change Variation ID SNP ID
1PARK2p.Cys253TyrVAR_019749
2PARK2p.Arg256CysVAR_019750rs150562946
3PARK2p.Arg275TrpVAR_019752rs34424986
4PARK2p.Asp280AsnVAR_019753

Clinvar genetic disease variations for Parkinson Disease, Late-Onset:

6
id Gene Variation Type Significance SNP ID Assembly Location
1MC1RNM_002386.3(MC1R): c.451C> T (p.Arg151Cys)single nucleotide variantPathogenic, risk factorrs1805007GRCh37Chr 16, 89986117: 89986117
2GLUD2NM_012084.3(GLUD2): c.1492T> G (p.Ser498Ala)single nucleotide variantPathogenicrs9697983GRCh37Chr X, 120183030: 120183030
3GBANM_001005741.2(GBA): c.1448T> C (p.Leu483Pro)single nucleotide variantPathogenic, risk factorrs421016GRCh37Chr 1, 155205043: 155205043
4GBANM_001005741.2(GBA): c.1448T> C (p.Leu483Pro)single nucleotide variantPathogenic, risk factorrs421016GRCh37Chr 1, 155205043: 155205043
5DNAJC13NM_015268.3(DNAJC13): c.2564A> G (p.Asn855Ser)single nucleotide variantPathogenicrs387907571GRCh37Chr 3, 132196839: 132196839
6MT-ND1m.3397A> Gsingle nucleotide variantPathogenicrs199476120GRCh37Chr MT, 3397: 3397

Expression for genes affiliated with Parkinson Disease, Late-Onset

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Search GEO for disease gene expression data for Parkinson Disease, Late-Onset.

Pathways for genes affiliated with Parkinson Disease, Late-Onset

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Pathways related to Parkinson Disease, Late-Onset according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
8.8TBP, MT-ND1, PARK2

Compounds for genes affiliated with Parkinson Disease, Late-Onset

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Compounds related to Parkinson Disease, Late-Onset according to GeneCards Suite gene sharing:

(show all 24)
idCompoundScoreTop Affiliating Genes
1tmao4310.2TBP, MAPT
2phosphocellulose4310.2TBP, MAPT
3trifluoroethanol43 1211.1MAPT, ADH1C
4formaldehyde43 2410.8ADH1C, MAPT, TBP
5glycerol43 24 1211.8TBP, MAPT, ADH1C
6silver439.6MAPT, MC1R
7nadph43 2410.6ADH1C, MAPT, GLUD2
8nad28 2410.5GLUD2, MT-ND1, ADH1C
9nadh43 24 1211.5ADH1C, MT-ND1, GLUD2
10rotenone439.3MT-ND1, PARK2
11lactacystin439.3MAPT, PARK2
12colchicine43 59 2 28 1213.3GBA, PARK2, MAPT
13adenylate439.2GBA, MC1R, TBP
14glutamine439.2TBP, MAPT, PARK2
15asparagine439.0PARK2, GBA
16zinc43 2410.0PARK2, ADH1C, MAPT, TBP
17iron43 249.9PARK2, MT-ND1, TBP
18levodopa43 129.9PARK2, MC1R
19leucine438.9GLUD2, TBP, PARK2, GBA
20cysteine438.9GBA, PARK2, MAPT, TBP
21glucose438.7MAPT, MT-ND1, PARK2, GBA
22proline438.5GBA, PARK2, MT-ND1, MAPT, TBP
23serine437.9GBA, MC1R, PARK2, MT-ND1, MAPT, TBP
24alanine437.8GLUD2, TBP, MAPT, MT-ND1, PARK2, MC1R

GO Terms for genes affiliated with Parkinson Disease, Late-Onset

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Cellular components related to Parkinson Disease, Late-Onset according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lysosomal membraneGO:00057659.1DNAJC13, VPS35, GBA

Biological processes related to Parkinson Disease, Late-Onset according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of autophagyGO:00105069.3MAPT, PARK2
2cell deathGO:00082198.2TBP, PARK2, VPS35, GBA

Products for genes affiliated with Parkinson Disease, Late-Onset

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Sources for Parkinson Disease, Late-Onset

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet