Parkinson Disease, Late-Onset malady
Categories: Genetic diseases, Rare diseases, Neuronal diseases, Mental diseases, Metabolic diseases
11Disease Ontology, 12diseasecard, 13DISEASES, 23GeneReviews, 24GeneTests, 25Genetics Home Reference, 26GTR, 29ICD10, 31ICD9CM, 34LifeMap Discovery®, 36MedGen, 37MedlinePlus, 38MeSH, 44NCIt, 47NIH Rare Diseases, 48NINDS, 49Novoseek, 51OMIM, 61SNOMED-CT, 63The Human Phenotype Ontology, 67UMLS, 69UniProtKB/Swiss-Prot
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Aliases & Descriptions for Parkinson Disease, Late-Onset:
Global: Genetic diseases, Rare diseases, Metabolic diseases
Anatomical: Neuronal diseases, Mental diseases
OMIM:51 Parkinson disease was first described by James Parkinson in 1817. It is the second most common neurodegenerative... (168600) more...
MalaCards based summary: Parkinson Disease, Late-Onset, also known as parkinson disease, is related to parkinson disease 1 and parkinson disease 6, early onset, and has symptoms including hallucinations, dysautonomia and urinary urgency. An important gene associated with Parkinson Disease, Late-Onset is GBA (Glucosylceramidase Beta), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Parkinsons Disease Pathway. The drugs biperiden and carbidopa have been mentioned in the context of this disorder. Affiliated tissues include brain, subthalamic nucleus and testes, and related mouse phenotypes are behavior/neurological and homeostasis/metabolism.
Disease Ontology:11 A synucleinopathy that has material basis in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.
Genetics Home Reference:25 Parkinson disease is a progressive disorder of the nervous system. The disorder affects several regions of the brain, especially an area called the substantia nigra that controls balance and movement.
NIH Rare Diseases:47 Parkinson disease belongs to a group of conditions called movement disorders. The four main symptoms are tremor, or trembling in hands, arms, legs, jaw, or head; rigidity, or stiffness of the limbs and trunk; bradykinesia, or slowness of movement; and postural instability, or impaired balance. These symptoms usually begin gradually and worsen with time. As they become more pronounced, patients may have difficulty walking, talking, or completing other simple tasks. Not everyone with one or more of these symptoms has Parkinson disease, as the symptoms sometimes appear in other diseases as well. Parkinson disease affects about 1 to 2 percent of people over the age of 60 years and the chance of developing Parkinson disease increases as we age. Although some Parkinson disease cases appear to be hereditary most cases are sporadic and occur in people with no apparent history of the disorder in their family. When three or more people are affected in a family, especially if they are diagnosed at an early age (under 50 years) there may be a gene making this family more likely to develop the condition. Currently, seven genes that cause some form of Parkinson's disease have been identified. Mutations (changes) in three known genes called SNCA (PARK1),UCHL1 (PARK 5), and LRRK2 (PARK8) and another mapped gene (PARK3) have been reported in families with dominant inheritance. Mutations in three known genes, PARK2 (PARK2), PARK7 (PARK7), and PINK1 (PARK6) have been found in affected individuals who had siblings with the condition but whose parents did not have Parkinson's disease (recessive inheritance). There is some research to suggest that these genes are also involved in early-onset Parkinson's disease (diagnosed before the age of 30) or in dominantly inherited Parkinson's disease but it is too early yet to be certain. However, in most cases inheriting a mutation will not cause someone to develop Parkinson's disease because there may be additional genes and environmental factors determining who will get the condition, when they get it and how it affects them. Last updated: 11/5/2015
MedlinePlus:37 Parkinson's disease (pd) is a type of movement disorder. it happens when nerve cells in the brain don't produce enough of a brain chemical called dopamine. sometimes it is genetic, but most cases do not seem to run in families. exposure to chemicals in the environment might play a role. symptoms begin gradually, often on one side of the body. later they affect both sides. they include trembling of hands, arms, legs, jaw and face stiffness of the arms, legs and trunk slowness of movement poor balance and coordination as symptoms get worse, people with the disease may have trouble walking, talking, or doing simple tasks. they may also have problems such as depression, sleep problems, or trouble chewing, swallowing, or speaking. there is no lab test for pd, so it can be difficult to diagnose. doctors use a medical history and a neurological examination to diagnose it. pd usually begins around age 60, but it can start earlier. it is more common in men than in women. there is no cure for pd. a variety of medicines sometimes help symptoms dramatically. surgery and deep brain stimulation (dbs) can help severe cases. with dbs, electrodes are surgically implanted in the brain. they send electrical pulses to stimulate the parts of the brain that control movement. nih: national institute of neurological disorders and stroke
NINDS:48 Parkinson's disease (PD) belongs to a group of conditions called motor system disorders, which are the result of the loss of dopamine-producing brain cells. The four primary symptoms of PD are tremor, or trembling in hands, arms, legs, jaw, and face; rigidity, or stiffness of the limbs and trunk; bradykinesia, or slowness of movement; and postural instability, or impaired balance and coordination. As these symptoms become more pronounced, patients may have difficulty walking, talking, or completing other simple tasks. PD usually affects people over the age of 60.
UniProtKB/Swiss-Prot:69 Parkinson disease: A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. Additional features are characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia. The pathology of Parkinson disease involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. The disease is progressive and usually manifests after the age of 50 years, although early-onset cases (before 50 years) are known. The majority of the cases are sporadic suggesting a multifactorial etiology based on environmental and genetic factors. However, some patients present with a positive family history for the disease. Familial forms of the disease usually begin at earlier ages and are associated with atypical clinical features.
Wikipedia:70 Parkinson\'s disease (PD) is a long-term degenerative disorder of the central nervous system that mainly... more...
GeneReviews for NBK1223
Human phenotypes related to Parkinson Disease, Late-Onset:63 (show all 22)
UMLS symptoms related to Parkinson Disease, Late-Onset:back pain, headache, myoclonus, pain, sciatica, seizures, syncope, tremor, chronic pain, cogwheel rigidity, bradykinesia, vertigo/dizziness, equilibration disorder, parkinsonian tremor, sleeplessness, parkinsonian rest tremor, freezing phenomenon, trembling; paralysis, tremor; parkinson's, constipation, muscle rigidity, sleep disturbances, sense of smell impaired
Drugs for Parkinson Disease, Late-Onset (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show top 50) (show all 499)
Interventional clinical trials:(show top 50) (show all 1925)
Search NIH Clinical Center for Parkinson Disease, Late-Onset
Inferred drug relations via UMLS67/NDF-RT45:
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Parkinson Disease, Late-Onset cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Parkinson Disease, Late-Onset:
Embryonic/Adult Cultured Cells Related to Parkinson Disease, Late-Onset:
MalaCards organs/tissues related to Parkinson Disease, Late-Onset:35
Brain, Subthalamic nucleus, Testes, Bone, Cortex, Eye, Heart
Data from LifeMap, the Embryonic Development and Stem Cells Database
Cells/anatomical compartments in embryo or adult related to Parkinson Disease, Late-Onset:
MGI Mouse Phenotypes related to Parkinson Disease, Late-Onset:40
UniProtKB/Swiss-Prot genetic disease variations for Parkinson Disease, Late-Onset:69
Clinvar genetic disease variations for Parkinson Disease, Late-Onset:5 (show all 18)
Copy number variations for Parkinson Disease, Late-Onset from CNVD:6 (show all 18)
Search GEO for disease gene expression data for Parkinson Disease, Late-Onset.
Pathways related to Parkinson Disease, Late-Onset according to KEGG:33
Pathways related to Parkinson Disease, Late-Onset according to GeneCards Suite gene sharing:
Cellular components related to Parkinson Disease, Late-Onset according to GeneCards Suite gene sharing:(show all 14)
Biological processes related to Parkinson Disease, Late-Onset according to GeneCards Suite gene sharing:(show all 43)
Molecular functions related to Parkinson Disease, Late-Onset according to GeneCards Suite gene sharing:
30ICD10 via Orphanet
39MESH via Orphanet
52OMIM via Orphanet
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
68UMLS via Orphanet