MCID: PRK057
MIFTS: 68

Parkinson Disease, Late-Onset

Categories: Genetic diseases, Rare diseases, Neuronal diseases, Mental diseases, Metabolic diseases

Aliases & Classifications for Parkinson Disease, Late-Onset

MalaCards integrated aliases for Parkinson Disease, Late-Onset:

Name: Parkinson Disease, Late-Onset 54 29 38 69
Parkinson Disease 54 12 23 50 24 25 71 29 52 42 69
Parkinson's Disease 38 12 50 25 51 41 14
Late Onset Parkinson Disease 12 71 14
Primary Parkinsonism 50 25 71
Paralysis Agitans 12 50 71
Pd 25 71
Parkinson Disease, Late-Onset, Susceptibility to 13
Parkinson Disease, Age of Onset, Modifier 54
Idiopathic Parkinson Disease 71
Lewy Body Parkinson Disease 71
Shaking Palsy 50
Park 71

Characteristics:

OMIM:

54
Miscellaneous:
progressive disorder
onset mid to late adulthood
insidious onset
levodopa-responsive

Inheritance:
isolated cases
multifactorial


HPO:

32
parkinson disease, late-onset:
Onset and clinical course insidious onset progressive
Inheritance sporadic


Classifications:



Summaries for Parkinson Disease, Late-Onset

NIH Rare Diseases : 50 parkinson disease belongs to a group of conditions called movement disorders. the four main symptoms are tremor, or trembling in hands, arms, legs, jaw, or head; rigidity, or stiffness of the limbs and trunk; bradykinesia, or slowness of movement; and postural instability, or impaired balance. these symptoms usually begin gradually and worsen with time.  as they become more pronounced, patients may have difficulty walking, talking, or completing other simple tasks.  not everyone with one or more of these symptoms has parkinson disease, as the symptoms sometimes appear in other diseases as well. parkinson disease affects about 1 to 2 percent of people over the age of 60 years and the chance of developing parkinson disease increases as we age. although some parkinson disease cases appear to be hereditary most cases are sporadic and occur in people with no apparent history of the disorder in their family. when three or more people are affected in a family, especially if they are diagnosed at an early age (under 50 years)  there may be a gene making this family more likely to develop the condition. currently, seven genes that cause some form of parkinson's disease have been identified. mutations (changes) in three known genes called snca (park1),uchl1 (park 5), and lrrk2 (park8) and another mapped gene (park3) have been reported in families with dominant inheritance. mutations in three known genes, park2 (park2), park7 (park7), and pink1 (park6) have been found in affected individuals who had siblings with the condition but whose parents did not have parkinson's disease (recessive inheritance). there is some research to suggest that these genes are also involved in early-onset parkinson's disease (diagnosed before the age of 30) or in dominantly inherited parkinson's disease but it is too early yet to be certain. however, in most cases inheriting a mutation will not cause someone to develop parkinson's disease because there may be additional genes and environmental factors determining who will get the condition, when they get it and how it affects them.  last updated: 11/5/2015

MalaCards based summary : Parkinson Disease, Late-Onset, also known as parkinson disease, is related to parkinson disease 1 and parkinson disease 6, early onset, and has symptoms including dysphagia, dystonia and dysarthria. An important gene associated with Parkinson Disease, Late-Onset is GLUD2 (Glutamate Dehydrogenase 2), and among its related pathways/superpathways are Parkinson's disease and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs Dopamine and Dopamine agonists have been mentioned in the context of this disorder. Affiliated tissues include Brain and Brain, and related phenotypes are behavior/neurological and homeostasis/metabolism

UniProtKB/Swiss-Prot : 71 Parkinson disease: A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. Additional features are characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia. The pathology of Parkinson disease involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. The disease is progressive and usually manifests after the age of 50 years, although early-onset cases (before 50 years) are known. The majority of the cases are sporadic suggesting a multifactorial etiology based on environmental and genetic factors. However, some patients present with a positive family history for the disease. Familial forms of the disease usually begin at earlier ages and are associated with atypical clinical features.

MedlinePlus : 41 parkinson's disease (pd) is a type of movement disorder. it happens when nerve cells in the brain don't produce enough of a brain chemical called dopamine. sometimes it is genetic, but most cases do not seem to run in families. exposure to chemicals in the environment might play a role. symptoms begin gradually, often on one side of the body. later they affect both sides. they include trembling of hands, arms, legs, jaw and face stiffness of the arms, legs and trunk slowness of movement poor balance and coordination as symptoms get worse, people with the disease may have trouble walking, talking, or doing simple tasks. they may also have problems such as depression, sleep problems, or trouble chewing, swallowing, or speaking. there is no lab test for pd, so it can be difficult to diagnose. doctors use a medical history and a neurological examination to diagnose it. pd usually begins around age 60, but it can start earlier. it is more common in men than in women. there is no cure for pd. a variety of medicines sometimes help symptoms dramatically. surgery and deep brain stimulation (dbs) can help severe cases. with dbs, electrodes are surgically implanted in the brain. they send electrical pulses to stimulate the parts of the brain that control movement. nih: national institute of neurological disorders and stroke

NINDS : 51 Parkinson's disease (PD) belongs to a group of conditions called motor system disorders, which are the result of the loss of dopamine-producing brain cells. The four primary symptoms of PD are tremor, or trembling in hands, arms, legs, jaw, and face; rigidity, or stiffness of the limbs and trunk; bradykinesia, or slowness of movement; and postural instability, or impaired balance and coordination. As these symptoms become more pronounced, patients may have difficulty walking, talking, or completing other simple tasks. PD usually affects people over the age of 60.  Early symptoms of PD are subtle and occur gradually.  In some people the disease progresses more quickly than in others.  As the disease progresses, the shaking, or tremor, which affects the majority of people with PD may begin to interfere with daily activities.  Other symptoms may include depression and other emotional changes; difficulty in swallowing, chewing, and speaking; urinary problems or constipation; skin problems; and sleep disruptions.  There are currently no blood or laboratory tests that have been proven to help in diagnosing sporadic PD.  Therefore the diagnosis is based on medical history and a neurological examination.  The disease can be difficult to diagnose accurately.   Doctors may sometimes request brain scans or laboratory tests in order to rule out other diseases.

Genetics Home Reference : 25 Parkinson disease is a progressive disorder of the nervous system. The disorder affects several regions of the brain, especially an area called the substantia nigra that controls balance and movement.

OMIM : 54
Parkinson disease was first described by James Parkinson in 1817. It is the second most common neurodegenerative disorder after Alzheimer disease (AD; 104300), affecting approximately 1% of the population over age 50 (Polymeropoulos et al., 1996). (168600)

Disease Ontology : 12 A synucleinopathy that has material basis in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.

GeneReviews: NBK1223

Related Diseases for Parkinson Disease, Late-Onset

Diseases in the Parkinson Disease, Late-Onset family:

Parkinson Disease 7, Autosomal Recessive Early-Onset Parkinson Disease 6, Early Onset
Parkinson Disease 19a, Juvenile-Onset Parkinson Disease 10
Parkinson Disease 16 Parkinson Disease 13
Parkinson Disease 11 Parkinson Disease 21
Parkinson Disease 18 Parkinson Disease 5
Parkinson Disease 4 Parkinson Disease 1
Parkinson Disease, Juvenile, Type 2 Parkinson Disease 22, Autosomal Dominant
Parkinson Disease 8 Parkinson Disease 23, Autosomal Recessive, Early Onset
Parkinson Disease 17 Parkinson Disease 20, Early-Onset
Parkinson Disease 15, Autosomal Recessive Parkinson Disease 14, Autosomal Recessive
Parkinson Disease 12 Juvenile-Onset Parkinson Disease
Early-Onset Parkinson Disease Lrrk2-Related Parkinson Disease
Vps35-Related Parkinson Disease Parkinson Disease Type 3
Parkinson Disease Type 9 Synj1-Related Parkinson Disease
Dnajc6-Related Parkinson Disease Eif4g1-Related Parkinson Disease
Fbxo7-Related Parkinson Disease Gigyf2-Related Parkinson Disease
Htra2-Related Parkinson Disease Park7-Related Parkinson Disease
Pla2g6-Related Parkinson Disease Snca-Related Parkinson Disease
Hereditary Late-Onset Parkinson Disease

Diseases related to Parkinson Disease, Late-Onset via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
id Related Disease Score Top Affiliating Genes
1 parkinson disease 1 35.2 GBA LRRK2 MAOB MAPT PARK7 PRKN
2 parkinson disease 6, early onset 34.9 PARK7 PINK1
3 parkinson disease 10 34.8 LRRK2 PARK7 PINK1 PRKN SNCA
4 personality disorder 33.4 DRD2 MAPT SLC6A3 SNCA
5 parkes weber syndrome 12.3
6 parkinson disease, juvenile, type 2 12.3
7 parkinson disease 4 12.2
8 parkinson disease 19a, juvenile-onset 12.2
9 parkinson disease 15, autosomal recessive 12.2
10 parkinson disease 17 12.1
11 parkinson disease 18 12.1
12 parkinson disease 20, early-onset 12.1
13 parkinson disease 14, autosomal recessive 12.0
14 parkinson disease 5 12.0
15 parkinson disease 21 12.0
16 parkinson disease 7, autosomal recessive early-onset 12.0
17 paralysis agitans, juvenile, of hunt 12.0
18 postencephalitic parkinson disease 12.0
19 parkinson disease 8 12.0
20 parkinson disease 11 12.0
21 parkinson disease 22, autosomal dominant 12.0
22 parkinson disease 23, autosomal recessive, early onset 12.0
23 parkinson disease 13 12.0
24 lrrk2-related parkinson disease 12.0
25 pink1 type of young-onset parkinson disease 11.9
26 parkin type of early-onset parkinson disease 11.9
27 early-onset parkinson disease 11.9
28 hereditary late-onset parkinson disease 11.9
29 vps35-related parkinson disease 11.9
30 parkinson disease susceptibility 11.8
31 pla2g6-related parkinson disease 11.8
32 parkinson disease type 3 11.8
33 parkes weber syndrome, rasa1-related 11.8
34 mt-tt related parkinson disease susceptibility 11.8
35 parkinson disease 16 11.8
36 snca-related parkinson disease 11.8
37 uchl1-related parkinson disease susceptibility 11.8
38 eif4g1-related parkinson disease 11.7
39 htra2-related parkinson disease 11.7
40 parkinson disease 12 11.7
41 parkinson disease type 9 11.7
42 juvenile-onset parkinson disease 11.7
43 dnajc6-related parkinson disease 11.7
44 prolidase deficiency 11.5
45 piebald trait, kit-related 11.4 ADH1C ATXN2 GBA LRRK2 MAPT PARK7
46 adrenal gland pheochromocytoma 11.4 GBA GDNF LRRK2 MAOB MAPT PARK7
47 13q12.3 microdeletion syndrome 11.4 GBA LRRK2 SNCA VPS35
48 prostate carcinoma in situ 11.3 ATXN3 GDNF LRRK2 MAOB MAPT PARK7
49 hepatic angiomyolipoma 11.3 ATXN3 GDNF LRRK2 MAOB MAPT PINK1
50 ganglioneuroma 11.3 DRD2 LRRK2 MAPT PARK7 PINK1 PRKN

Comorbidity relations with Parkinson Disease, Late-Onset via Phenotypic Disease Network (PDN): (show top 50) (show all 52)


Active Peptic Ulcer Disease Acute Conjunctivitis
Acute Cystitis Alzheimer Disease
Anxiety Disorder Atypical Depressive Disorder
Autonomic Nervous System Disease Bipolar Disorder
Blepharitis Bronchitis
Bronchopneumonia Cerebral Atherosclerosis
Cerebral Degeneration Cerebrovascular Disease
Chronic Myocardial Ischemia Communicating Hydrocephalus
Conjunctivitis Cystitis
Decubitus Ulcer Deficiency Anemia
Delusional Disorder Dependent Personality Disorder
Dysthymic Disorder Early-Onset Generalized Limb-Onset Dystonia
Encephalopathy Erythematosquamous Dermatosis
Esophagitis Fecal Incontinence
Generalized Atherosclerosis Heart Disease
Hypothyroidism Intestinal Volvulus
Iron Deficiency Anemia Leukodystrophy
Major Affective Disorder-7 Marasmus
Mood Disorder Neurogenic Bladder
Obstructive Hydrocephalus Osteoporosis
Paralytic Ileus Paranoid Schizophrenia
Pernicious Anemia Personality Disorder
Prostatic Hypertrophy Protein-Energy Malnutrition
Pseudobulbar Palsy Schizophrenia
Schizophreniform Disorder Swallowing Disorders

Graphical network of the top 20 diseases related to Parkinson Disease, Late-Onset:



Diseases related to Parkinson Disease, Late-Onset

Symptoms & Phenotypes for Parkinson Disease, Late-Onset

Symptoms via clinical synopsis from OMIM:

54

Abdomen- Gastroin testinal:
dysphagia
constipation

Head And Neck- Face:
masked facies

Genitourinary- Bladder:
urinary urgency

Neurologic- Central Nervous System:
dystonia
dysarthria
sleep disturbances
parkinsonism
bradykinesia
more
Neurologic- Behavioral Psychiatric Manifestations:
depression

Head And Neck- Nose:
decreased sense of smell


Clinical features from OMIM:

168600

Human phenotypes related to Parkinson Disease, Late-Onset:

32 (show all 22)
id Description HPO Frequency HPO Source Accession
1 dysphagia 32 HP:0002015
2 dystonia 32 HP:0001332
3 dysarthria 32 HP:0001260
4 personality changes 32 HP:0000751
5 parkinsonism 32 HP:0001300
6 bradykinesia 32 HP:0002067
7 rigidity 32 HP:0002063
8 postural instability 32 HP:0002172
9 depression 32 HP:0000716
10 hallucinations 32 occasional (7.5%) HP:0000738
11 urinary urgency 32 HP:0000012
12 constipation 32 HP:0002019
13 resting tremor 32 HP:0002322
14 dementia 32 HP:0000726
15 lewy bodies 32 HP:0100315
16 dysautonomia 32 occasional (7.5%) HP:0002459
17 mask-like facies 32 HP:0000298
18 sleep disturbance 32 HP:0002360
19 weak voice 32 HP:0001621
20 neuronal loss in central nervous system 32 HP:0002529
21 short stepped shuffling gait 32 HP:0007311
22 substantia nigra gliosis 32 HP:0011960

UMLS symptoms related to Parkinson Disease, Late-Onset:


angina pectoris, back pain, headache, myoclonus, pain, sciatica, seizures, syncope, tremor, chronic pain, vertigo/dizziness, equilibration disorder, sleeplessness, constipation, muscle rigidity, sleep disturbances, bradykinesia, hyposmia

MGI Mouse Phenotypes related to Parkinson Disease, Late-Onset:

44 (show all 11)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.4 ATXN2 ATXN3 DRD2 GBA GDNF LRRK2
2 homeostasis/metabolism MP:0005376 10.3 ADH1C ATXN2 ATXN3 DRD2 GBA LRRK2
3 cellular MP:0005384 10.27 DRD2 GBA GDNF LRRK2 MAOB MAPT
4 growth/size/body region MP:0005378 10.22 PRKN SLC6A3 SNCA TBP TH ADH1C
5 cardiovascular system MP:0005385 10.18 DRD2 GBA GDNF LRRK2 MAPT PINK1
6 mortality/aging MP:0010768 10.1 ADH1C ATXN2 DRD2 GBA GDNF LRRK2
7 endocrine/exocrine gland MP:0005379 10.09 ATXN2 DRD2 GBA GDNF LRRK2 PINK1
8 nervous system MP:0003631 10.06 SLC6A3 SNCA TBP TH VPS35 ATXN2
9 integument MP:0010771 9.92 DRD2 GBA LRRK2 MAPT PRKN SLC6A3
10 no phenotypic analysis MP:0003012 9.61 DRD2 LRRK2 MAPT PINK1 PRKN SNCA
11 taste/olfaction MP:0005394 9.02 DRD2 MAPT PINK1 SLC6A3 SNCA

Drugs & Therapeutics for Parkinson Disease, Late-Onset

Drugs for Parkinson Disease, Late-Onset (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 2 51-61-6, 62-31-7 681
2 Dopamine agonists Phase 2
3 N 0437 Phase 2
4 Neurotransmitter Agents Phase 2
5 Dopamine Agents Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Mindfulness Based Intervention (MBI) on the Quality of Life and Non-Motor Symptoms (NMS) of Persons With PD Completed NCT01607697 Phase 2
2 Possible Use of Rotigotine in Subjects 70 Years and Older With Late Onset of Disease Terminated NCT02103465 Phase 2 Rotigotine;Placebo
3 Parkin Mutations and Their Functional Consequences Unknown status NCT00136721 Phase 1
4 GADGET-PD Genetic and Digital Diagnosis of Essential Tremor and Parkinson's Disease Trial Active, not recruiting NCT02668835

Search NIH Clinical Center for Parkinson Disease, Late-Onset

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Parkinson Disease, Late-Onset cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: parkinson disease

Genetic Tests for Parkinson Disease, Late-Onset

Genetic tests related to Parkinson Disease, Late-Onset:

id Genetic test Affiliating Genes
1 Parkinson Disease 29 24 VPS35
2 Parkinson Disease, Late-Onset 29

Anatomical Context for Parkinson Disease, Late-Onset

MalaCards organs/tissues related to Parkinson Disease, Late-Onset:

39
Brain, Testes, Skin, Bone
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Parkinson Disease, Late-Onset:
id Tissue Anatomical CompartmentCell Relevance
1 Brain Substantia Nigra pars Compacta Adult Dopaminergic Neurons Potential therapeutic candidate, affected by disease
2 Brain Forebrain White Matter Fibrous Astrocyte Cells Potential therapeutic candidate
3 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
4 Brain Neocortex Protoplasmic Astrocyte Cells Potential therapeutic candidate
5 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Parkinson Disease, Late-Onset

Variations for Parkinson Disease, Late-Onset

UniProtKB/Swiss-Prot genetic disease variations for Parkinson Disease, Late-Onset:

71
id Symbol AA change Variation ID SNP ID
1 PRKN p.Cys253Tyr VAR_019749 rs747427602
2 PRKN p.Arg256Cys VAR_019750 rs150562946
3 PRKN p.Arg275Trp VAR_019752 rs34424986
4 PRKN p.Asp280Asn VAR_019753 rs72480422

ClinVar genetic disease variations for Parkinson Disease, Late-Onset:

6 (show all 17)
id Gene Variation Type Significance SNP ID Assembly Location
1 ATXN3 NM_004993.5(ATXN3): c.892_894CAG(8_36) (p.Gln298_Gln305=) NT expansion Pathogenic,risk factor rs193922928 GRCh37 Chromosome 14, 92537355: 92537357
2 GBA NM_000157.3(GBA): c.1448T> C (p.Leu483Pro) single nucleotide variant Pathogenic,risk factor rs421016 GRCh37 Chromosome 1, 155205043: 155205043
3 GBA NM_001005741.2(GBA): c.1226A> G (p.Asn409Ser) single nucleotide variant Pathogenic/Likely pathogenic,risk factor rs76763715 GRCh37 Chromosome 1, 155205634: 155205634
4 GBA NM_000157.3(GBA): c.1504C> T (p.Arg502Cys) single nucleotide variant Pathogenic,risk factor rs80356771 GRCh37 Chromosome 1, 155204987: 155204987
5 GBA NM_001005741.2(GBA): c.1444G> A (p.Asp482Asn) single nucleotide variant risk factor rs75671029 GRCh37 Chromosome 1, 155205047: 155205047
6 ATXN8OS NR_002717.2(ATXN8OS): n.1103_1105CTG(15_40) NT expansion Pathogenic,risk factor rs193922930 GRCh37 Chromosome 13, 70713516: 70713518
7 ATXN2 NM_002973.3(ATXN2): c.496_498CAG(15_24) (p.Gln188_Pro189insGlnGln) NT expansion risk factor rs193922927 GRCh37 Chromosome 12, 112036785: 112036787
8 TBP NM_003194.4(TBP): c.172_174CAG(25_42) (p.Gln95(25_42)) NT expansion Pathogenic,risk factor rs193922935 GRCh37 Chromosome 6, 170870996: 170870998
9 MT-ND1 m.3397A> G single nucleotide variant Pathogenic rs199476120 GRCh37 Chromosome MT, 3397: 3397
10 GLUD2 NM_012084.3(GLUD2): c.1492T> G (p.Ser498Ala) single nucleotide variant Pathogenic rs9697983 GRCh37 Chromosome X, 120183030: 120183030
11 MAPT NM_016835.4(MAPT): c.1838_1840delATA (p.Asn613del) deletion Pathogenic,risk factor rs63751392 GRCh37 Chromosome 17, 44087740: 44087742
12 VPS13C NM_020821.2(VPS13C): c.9568G> T (p.Glu3190Ter) single nucleotide variant Pathogenic rs869312810 GRCh37 Chromosome 15, 62174851: 62174851
13 VPS13C NM_020821.2(VPS13C): c.8445+2T> G single nucleotide variant Pathogenic rs869312809 GRCh37 Chromosome 15, 62207830: 62207830
14 VPS13C NM_020821.2(VPS13C): c.4777delC (p.Gln1593Lysfs) deletion Pathogenic rs869312811 GRCh37 Chromosome 15, 62239491: 62239491
15 VPS13C NM_020821.2(VPS13C): c.4165G> C (p.Gly1389Arg) single nucleotide variant Pathogenic rs369100678 GRCh37 Chromosome 15, 62250807: 62250807
16 VPS13C NM_020821.2(VPS13C): c.806_807insCAGA (p.Arg269Serfs) insertion Pathogenic rs879253853 GRCh37 Chromosome 15, 62305256: 62305257
17 LRRK2 NM_198578.3(LRRK2): c.4321C> A (p.Arg1441Ser) single nucleotide variant Pathogenic rs33939927 GRCh37 Chromosome 12, 40704236: 40704236

Copy number variations for Parkinson Disease, Late-Onset from CNVD:

7 (show all 18)
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 23691 1 173049146 173078950 Copy number PAPPA2 Parkinson disease
2 27433 1 20832534 20850591 Genomic rearrangemen ts PINK1 Parkinson disease
3 60306 11 84948993 84958207 Copy number DLG2 Parkinson disease
4 115237 17 55581582 55809920 Copy number USP32 Parkinson disease
5 132540 19 59310648 59326954 Genomic rearrangemen ts PRPF31 Parkinson disease
6 170895 3 161200000 193800000 Copy number EIF4G1 Parkinson disease
7 186570 4 36900000 88200000 Duplication or tripl ication SNCA Parkinson disease
8 187375 4 48300000 99100000 Copy number SNCA Parkinson disease
9 189219 4 71528873 71716513 Copy number ENAM Parkinson disease
10 190419 4 88200000 94000000 Triplication SNCA Parkinson disease
11 190793 4 90645250 90759447 Duplication SNCA Parkinson disease
12 190807 4 90865727 90978470 Duplication or tripl ication SNCA Parkinson disease
13 195489 5 151389412 151513092 Copy number GLRA1 Parkinson disease
14 207784 6 161000000 164500000 Gain or loss PARK2 Parkinson disease
15 207856 6 161768590 163148834 Copy number PARK2 Parkinson disease
16 207937 6 162471089 162677104 Copy number PARK2 Parkinson disease
17 211738 6 336751 356443 Deletion IRF4 Parkinson disease
18 237664 8 25038472 25171648 Copy number Parkinson disease

Expression for Parkinson Disease, Late-Onset

Search GEO for disease gene expression data for Parkinson Disease, Late-Onset.

Pathways for Parkinson Disease, Late-Onset

Pathways related to Parkinson Disease, Late-Onset according to KEGG:

37
id Name Kegg Source Accession
1 Parkinson's disease hsa05012

Pathways related to Parkinson Disease, Late-Onset according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.26 DRD2 LRRK2 MAPT MT-ND1 PARK7 PINK1
2
Show member pathways
12.41 ATXN2 ATXN3 PARK7 PINK1 PRKN SLC6A3
3 12.21 LRRK2 MAPT PARK7 PINK1 PRKN SNCA
4
Show member pathways
11.74 DRD2 MAOB SLC6A3 TH
5
Show member pathways
11.46 ADH1C MAOB TH
6 11.15 ATXN2 LRRK2 PARK7 PINK1 PRKN SLC6A3
7 10.94 MAOB PARK7 PRKN SLC6A3 SNCA TH
8 10.6 MAOB TH
9 10.51 ATXN3 PRKN

GO Terms for Parkinson Disease, Late-Onset

Cellular components related to Parkinson Disease, Late-Onset according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 perinuclear region of cytoplasm GO:0048471 9.99 ATXN2 PARK7 PINK1 PRKN SNCA VPS35
2 mitochondrion GO:0005739 9.9 GLUD2 LRRK2 MAOB MT-ND1 PARK7 PINK1
3 dendrite GO:0030425 9.89 DRD2 LRRK2 MAPT MT-ND1 TH
4 mitochondrial outer membrane GO:0005741 9.78 LRRK2 MAOB PINK1 VPS13C
5 neuron projection GO:0043005 9.73 LRRK2 PARK7 PRKN SLC6A3 TH VPS35
6 cell body GO:0044297 9.72 MAPT PARK7 PINK1
7 presynapse GO:0098793 9.71 PARK7 PRKN SLC6A3
8 terminal bouton GO:0043195 9.7 LRRK2 SNCA TH
9 mitochondrial respiratory chain complex I GO:0005747 9.63 MT-ND1 PARK7 SNCA
10 growth cone GO:0030426 9.54 LRRK2 MAPT SNCA
11 neuronal cell body GO:0043025 9.5 LRRK2 MAPT MT-ND1 SLC6A3 SNCA TH
12 Lewy body GO:0097413 9.4 PINK1 PRKN
13 mitochondrion-derived vesicle GO:0099073 9.32 PRKN VPS35
14 axon GO:0030424 9.23 DRD2 LRRK2 MAPT PARK7 PINK1 SLC6A3
15 cytoplasm GO:0005737 10.31 ADH1C ATXN2 ATXN3 GLUD2 LRRK2 MAPT

Biological processes related to Parkinson Disease, Late-Onset according to GeneCards Suite gene sharing:

(show top 50) (show all 71)
id Name GO ID Score Top Affiliating Genes
1 autophagy GO:0006914 9.99 LRRK2 PARK7 PINK1 PRKN
2 response to drug GO:0042493 9.99 DRD2 MAOB MT-ND1 SLC6A3 SNCA TH
3 negative regulation of gene expression GO:0010629 9.97 MAPT PARK7 PINK1 PRKN VPS35
4 response to ethanol GO:0045471 9.94 DRD2 MAOB SLC6A3 TH
5 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.9 PARK7 PINK1 SNCA
6 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 9.9 GBA LRRK2 PRKN
7 locomotory behavior GO:0007626 9.9 DRD2 PRKN SLC6A3 TH
8 cellular response to oxidative stress GO:0034599 9.89 LRRK2 PARK7 PINK1 SNCA
9 negative regulation of neuron apoptotic process GO:0043524 9.88 GDNF PARK7 PINK1 PRKN SNCA
10 regulation of autophagy GO:0010506 9.87 LRRK2 MAPT PRKN
11 negative regulation of protein phosphorylation GO:0001933 9.86 LRRK2 PARK7 PRKN SNCA
12 protein destabilization GO:0031648 9.85 PRKN SNCA VPS35
13 response to nicotine GO:0035094 9.84 DRD2 SLC6A3 TH
14 response to cocaine GO:0042220 9.84 DRD2 SLC6A3 SNCA
15 regulation of mitochondrial membrane potential GO:0051881 9.81 PARK7 PINK1 PRKN
16 adult locomotory behavior GO:0008344 9.8 GDNF PARK7 PRKN SNCA
17 regulation of reactive oxygen species metabolic process GO:2000377 9.78 PINK1 PRKN SNCA
18 regulation of dopamine secretion GO:0014059 9.76 DRD2 PRKN SNCA
19 regulation of protein ubiquitination GO:0031396 9.74 PINK1 PRKN
20 negative regulation of hydrogen peroxide-induced cell death GO:1903206 9.74 LRRK2 PARK7
21 response to corticosterone GO:0051412 9.74 MAOB TH
22 microglial cell activation GO:0001774 9.74 MAPT SNCA
23 startle response GO:0001964 9.74 DRD2 PRKN
24 cellular response to dopamine GO:1903351 9.74 LRRK2 PRKN
25 neurotransmitter biosynthetic process GO:0042136 9.74 SLC6A3 TH
26 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 9.74 LRRK2 PARK7 PRKN
27 negative regulation of macroautophagy GO:0016242 9.73 LRRK2 PINK1
28 prepulse inhibition GO:0060134 9.73 DRD2 SLC6A3
29 supramolecular fiber organization GO:0097435 9.73 MAPT SNCA
30 negative regulation of oxidative stress-induced neuron death GO:1903204 9.73 PARK7 PINK1
31 negative regulation of autophagosome assembly GO:1902902 9.73 LRRK2 PINK1
32 mitochondrion organization GO:0007005 9.73 GBA LRRK2 PARK7 PINK1 PRKN VPS13C
33 peristalsis GO:0030432 9.72 DRD2 GDNF
34 regulation of dopamine metabolic process GO:0042053 9.72 PRKN SLC6A3
35 negative regulation of cell death GO:0060548 9.72 PARK7 PRKN
36 adenohypophysis development GO:0021984 9.72 DRD2 SLC6A3
37 positive regulation of mitochondrial fission GO:0090141 9.72 PINK1 PRKN VPS35
38 negative regulation of protein homooligomerization GO:0032463 9.71 GBA VPS35
39 regulation of locomotion GO:0040012 9.71 LRRK2 SNCA
40 regulation of mitochondrial fission GO:0090140 9.71 LRRK2 MAPT
41 intracellular distribution of mitochondria GO:0048312 9.71 LRRK2 MAPT
42 dopamine metabolic process GO:0042417 9.71 DRD2 PRKN SNCA
43 dopamine catabolic process GO:0042420 9.7 MAOB SLC6A3
44 cellular response to toxic substance GO:0097237 9.7 PINK1 PRKN
45 regulation of protein targeting to mitochondrion GO:1903214 9.7 PINK1 PRKN
46 positive regulation of mitophagy GO:1903599 9.7 PARK7 PRKN
47 regulation of mitochondrion organization GO:0010821 9.7 PINK1 PRKN VPS35
48 protein localization to mitochondrion GO:0070585 9.69 LRRK2 PRKN
49 positive regulation of dopamine secretion GO:0033603 9.69 GDNF PINK1
50 regulation of dopamine uptake involved in synaptic transmission GO:0051584 9.68 DRD2 GDNF

Molecular functions related to Parkinson Disease, Late-Onset according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.91 DRD2 GDNF LRRK2 MAOB MAPT PARK7
2 receptor binding GO:0005102 9.8 DRD2 GBA GDNF PARK7 SLC6A3
3 oxidoreductase activity GO:0016491 9.73 ADH1C GLUD2 MAOB MT-ND1 SNCA TH
4 identical protein binding GO:0042802 9.7 ATXN3 DRD2 LRRK2 MAPT PARK7 PRKN
5 tubulin binding GO:0015631 9.5 LRRK2 MAPT PRKN
6 ubiquitin-specific protease binding GO:1990381 9.48 PARK7 PRKN
7 phospholipase binding GO:0043274 9.46 PRKN SNCA
8 enzyme binding GO:0019899 9.43 MAPT PARK7 PRKN SNCA TBP TH
9 cuprous ion binding GO:1903136 9.37 PARK7 SNCA
10 dopamine binding GO:0035240 8.8 DRD2 SLC6A3 TH

Sources for Parkinson Disease, Late-Onset

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
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44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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