MCID: PRK057
MIFTS: 28

Parkinson Disease, Late-Onset malady

Genetic diseases, Mental diseases, Rare diseases, Neuronal diseases, Eye diseases categories

Summaries for Parkinson Disease, Late-Onset

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Sources:
48OMIM, 34MalaCards
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MalaCards: Parkinson Disease, Late-Onset, also known as parkinson-dementia syndrome, is related to parkinson's disease and wolff-parkinson-white syndrome. An important gene associated with Parkinson Disease, Late-Onset is GBA (glucosidase, beta, acid). The compounds colchicine and asparagine have been mentioned in the context of this disorder. Related mouse phenotypes are integument and respiratory system.

Description from OMIM:48 168600

Aliases & Classifications for Parkinson Disease, Late-Onset

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Sources:
48OMIM, 63UMLS, 26ICD10
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Classifications:



Aliases & Descriptions:

parkinson disease, late-onset 48
parkinson-dementia syndrome 63


External Ids:

ICD1026 F02.3

Related Diseases for Parkinson Disease, Late-Onset

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of diseases related to Parkinson Disease, Late-Onset:



Diseases related to parkinson disease, late-onset

Symptoms for Parkinson Disease, Late-Onset

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48OMIM
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Symptoms by clinical synopsis from OMIM:

168600

Clinical features from OMIM:

168600

Drugs & Therapeutics for Parkinson Disease, Late-Onset

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Parkinson Disease, Late-Onset

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Anatomical Context for Parkinson Disease, Late-Onset

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Animal Models for Parkinson Disease, Late-Onset or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Parkinson Disease, Late-Onset:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.1PARK2, GBA
2MP:00053889.0PARK2, GBA
3MP:00053908.8PARK2, GBA

Publications for Parkinson Disease, Late-Onset

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Variations for Parkinson Disease, Late-Onset

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Sources:
65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 8dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Parkinson Disease, Late-Onset:

65
id Symbol AA change Variation ID SNP ID
1PARK2p.Cys253TyrVAR_019749
2PARK2p.Arg256CysVAR_019750rs150562946
3PARK2p.Arg275TrpVAR_019752rs34424986
4PARK2p.Asp280AsnVAR_019753

Clinvar genetic disease variations for Parkinson Disease, Late-Onset:

1
id Gene Name Type Significance SNP ID Assembly Location
1MC1RNM_002386.3(MC1R): c.451C> T (p.Arg151Cys)single nucleotide variantPathogenic, risk factorrs1805007GRCh37Chr 16, 89986117: 89986117
2GLUD2NM_012084.3(GLUD2): c.1492T> G (p.Ser498Ala)single nucleotide variantPathogenicrs9697983GRCh37Chr X, 120183030: 120183030
3GBANM_001005741.2(GBA): c.1448T> C (p.Leu483Pro)single nucleotide variantPathogenic, risk factorrs421016GRCh37Chr 1, 155205043: 155205043
4GBANM_001005741.2(GBA): c.1226A> G (p.Asn409Ser)single nucleotide variantPathogenic, risk factorrs76763715GRCh37Chr 1, 155205634: 155205634
5GBANM_001005741.2(GBA): c.1504C> T (p.Arg502Cys)single nucleotide variantPathogenic, risk factorrs80356771GRCh37Chr 1, 155204987: 155204987
6GBANM_001005741.2(GBA): c.1448T> C (p.Leu483Pro)single nucleotide variantPathogenic, risk factorrs421016GRCh37Chr 1, 155205043: 155205043
7DNAJC13NM_015268.3(DNAJC13): c.2564A> G (p.Asn855Ser)single nucleotide variantPathogenicrs387907571GRCh37Chr 3, 132196839: 132196839
8MT-ND1m.3397A> Gsingle nucleotide variantPathogenicrs199476120GRCh37Chr MT, 3397: 3397

Expression for genes affiliated with Parkinson Disease, Late-Onset

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Parkinson Disease, Late-Onset

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Pathways for genes affiliated with Parkinson Disease, Late-Onset

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Compounds for genes affiliated with Parkinson Disease, Late-Onset

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Sources:
46Novoseek, 62Tocris Bioscience, 3BitterDB, 30IUPHAR, 12DrugBank, 25HMDB
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Compounds related to Parkinson Disease, Late-Onset according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1colchicine46 62 3 30 1213.4PARK2, GBA
2asparagine469.4PARK2, GBA
3ceramide469.3GBA, PARK2
4proline469.3PARK2, GBA
5leucine469.3PARK2, GBA
6steroid469.2GBA, PARK2
7nitric oxide46 25 1211.2PARK2, GBA
8oxygen46 2510.1PARK2, GBA
9lipid469.1PARK2, GBA
10cysteine469.0GBA, PARK2
11glucose468.8PARK2, GBA

GO Terms for genes affiliated with Parkinson Disease, Late-Onset

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Sources:
17Gene Ontology
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Biological processes related to Parkinson Disease, Late-Onset according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell deathGO:0082199.1PARK2, GBA

Products for genes affiliated with Parkinson Disease, Late-Onset

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Parkinson Disease, Late-Onset

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet