MCID: PRK073
MIFTS: 30

Parkinson Disease Susceptibility

Categories: Genetic diseases

Aliases & Classifications for Parkinson Disease Susceptibility

MalaCards integrated aliases for Parkinson Disease Susceptibility:

Name: Parkinson Disease Susceptibility 24

Classifications:



Summaries for Parkinson Disease Susceptibility

MalaCards based summary : Parkinson Disease Susceptibility is related to adh1c-related parkinson disease susceptibility and atxn2-related parkinson disease susceptibility. An important gene associated with Parkinson Disease Susceptibility is UCHL1 (Ubiquitin C-Terminal Hydrolase L1), and among its related pathways/superpathways are Chks in Checkpoint Regulation and Neuroscience. The drugs Donepezil and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include bone and subthalamic nucleus, and related phenotypes are Decreased viability ratio and Decreased cell proliferation

Related Diseases for Parkinson Disease Susceptibility

Diseases in the Parkinson Disease Susceptibility family:

Adh1c-Related Parkinson Disease Susceptibility Atxn2-Related Parkinson Disease Susceptibility
Gba-Related Parkinson Disease Susceptibility Mt-Tt Related Parkinson Disease Susceptibility
Uchl1-Related Parkinson Disease Susceptibility

Diseases related to Parkinson Disease Susceptibility via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
id Related Disease Score Top Affiliating Genes
1 adh1c-related parkinson disease susceptibility 11.9
2 atxn2-related parkinson disease susceptibility 11.9
3 gba-related parkinson disease susceptibility 11.9
4 mt-tt related parkinson disease susceptibility 11.9
5 uchl1-related parkinson disease susceptibility 11.9
6 13q12.3 microdeletion syndrome 10.5 GBA LRRK2 SNCA
7 spastic paraplegia 79, autosomal recessive 10.5 MAPT UCHL1
8 degenerative myopia 10.5 GBA UCHL1
9 parkinson disease 10 10.4 LRRK2 PARK7 SNCA
10 sebaceous gland disease 10.4 LRRK2 SNCA
11 riedel's fibrosing thyroiditis 10.4 LRRK2 MAPT SNCA
12 cough headache 10.3 GBA MAPT UCHL1
13 nosophobia 10.3 LRRK2 MAPT SNCA
14 central cervical cord syndrome 10.3 SNCA UCHL1
15 parietal foramina 3 10.3 LRRK2 MAPT SNCA
16 celiac disease 12 10.3 LRRK2 PARK7 SNCA UCHL1
17 sparc-related osteogenesis imperfecta 10.2 LRRK2 MAPT PARK7 SNCA
18 atrial fibrillation, familial, 8 10.2 GSK3B MAPT
19 mast syndrome 10.2 LRRK2 MAPT PARK7 SNCA
20 hepatic angiomyolipoma 10.2 LRRK2 MAPT SNCA
21 supranuclear palsy, progressive atypical 10.2 LRRK2 MAPT PARK7 SNCA
22 fastkd2-related infantile mitochondrial encephalomyopathy 10.2 GBA LRRK2 MAPT SNCA
23 ganglioneuroma 10.2 LRRK2 MAPT PARK7 SNCA
24 prostate carcinoma in situ 10.1 LRRK2 MAPT PARK7 SNCA
25 ectodermal dysplasia 13, hair/tooth type 10.1 ATP13A2 LRRK2 PARK7 SNCA
26 hyperekplexia, hereditary 1, autosomal dominant or recessive 10.1 MAPT SNCA
27 adrenal gland pheochromocytoma 9.9 GBA LRRK2 MAPT PARK7 SNCA
28 parkinson disease 1 9.9 GBA LRRK2 MAPT PARK7 SNCA
29 eumycotic mycetoma 9.9 ATP13A2 MAPT PARK7 SNCA
30 waldenstroem's macroglobulinemia 9.8 ATP13A2 GBA LRRK2 PARK7 SNCA
31 pick disease 9.7 ATXN2 LRRK2 MAPT SNCA
32 parkinson disease, late-onset 8.4 ADH1C ATXN2 FGF20 GBA LRRK2 MAPT
33 piebald trait, kit-related 4.8 ADH1C ADPRH ATP13A2 ATXN2 FGF20 GAK

Graphical network of the top 20 diseases related to Parkinson Disease Susceptibility:



Diseases related to Parkinson Disease Susceptibility

Symptoms & Phenotypes for Parkinson Disease Susceptibility

GenomeRNAi Phenotypes related to Parkinson Disease Susceptibility according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability ratio GR00368-A 9.23 ADPRH ATP13A2 FGF20 GSK3B MAPT PARK7
2 Decreased cell proliferation GR00353-A 9.13 GAK GSK3B LRRK2

MGI Mouse Phenotypes related to Parkinson Disease Susceptibility:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.06 SNCA GBA UCHL1 GSK3B LRRK2 MAPT
2 growth/size/body region MP:0005378 9.96 PTGS2 GAK SNCA GBA UCHL1 GSK3B
3 homeostasis/metabolism MP:0005376 9.9 GAK SNCA GBA UCHL1 GSK3B LRRK2
4 integument MP:0010771 9.56 SNCA GBA UCHL1 LRRK2 MAPT FGF20
5 nervous system MP:0003631 9.4 SNCA GBA UCHL1 GSK3B LRRK2 MAPT

Drugs & Therapeutics for Parkinson Disease Susceptibility

Drugs for Parkinson Disease Susceptibility (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Donepezil Approved Phase 2 120014-06-4 3152
2
Dopamine Approved Phase 2 51-61-6, 62-31-7 681
3
Cholecalciferol Approved, Nutraceutical Phase 2 67-97-0 6221 10883523 5280795
4
Ergocalciferol Approved, Nutraceutical Phase 2 50-14-6 5280793
5
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2 1406-16-2
6 Bone Density Conservation Agents Phase 2
7 Ergocalciferols Phase 2
8 Micronutrients Phase 2
9 Trace Elements Phase 2
10 Vitamins Phase 2
11 Cholinergic Agents Phase 2
12 Cholinesterase Inhibitors Phase 2
13 Dopamine Agents Phase 2
14 Dopamine agonists Phase 2
15 Neurotransmitter Agents Phase 2
16 Nootropic Agents Phase 2
17 Calciferol Nutraceutical Phase 2
18 Vitamin D2 Nutraceutical Phase 2
19
Iron Approved 7439-89-6 23925
20
Menthol Approved 2216-51-5 16666
21 Anesthetics

Interventional clinical trials:

(show all 20)

id Name Status NCT ID Phase Drugs
1 The Effects of Vitamin D and Bone Loss in Parkinson's Disease Completed NCT00907972 Phase 2
2 Effect of Donepezil on Cognition in Parkinson's Disease With Mild Cognitive Impairment (PD-MCI) Recruiting NCT02450786 Phase 2 Donepezil
3 Cohorts and Collections: Clinical and Genetic Study of Parkinson's Disease and Epilepsies Terminated NCT00142363 Phase 1
4 Functional Characterization of Parkin + Patients Terminated NCT00142311 Phase 1
5 Multifunctional Substrate for Early Detection of Oxidative Stress Susceptibility and Application to Parkinson's Disease Unknown status NCT00271141
6 Consortium On Risk for Early-onset Parkinson's Disease (CORE PD) Unknown status NCT00104585
7 Genetic Study in Young Onset Parkinson's Disease Unknown status NCT01529970
8 Parkinson's Diseases Susceptibility Genes and Pesticides Completed NCT00044590
9 LRRK2 and Other Novel Exosome Proteins in Parkinson's Disease Completed NCT01860118
10 Haptoglobin and Iron in Parkinson's Disease Completed NCT02422992
11 Exploration of the Reward System by Functional MRI in Parkinson's Disease Patients With and Without REM Sleep Behavior Disorder Recruiting NCT02824341
12 Imaging Biomarkers in Parkinson s Disease Recruiting NCT01496599
13 Parkinson Disease and DBS: Cognitive Effects in GBA Mutation Carriers Recruiting NCT03234478
14 One-year Follow-up of Iron in Basal Ganglia - R2*: a Biomarker of Parkinson's Disease Progression? Recruiting NCT02816645
15 Evaluation of Dysfunction of the Basal Ganglia Before a Parkinsonian Walking in the Elderly: Risk of Falling and Confusional State Recruiting NCT02885493
16 Vascular Abnormalities in Idiopathic Parkinson's Disease Active, not recruiting NCT02045420
17 PET/MR Imaging in Patients With Short and Long Standing Parkinson's Disease Not yet recruiting NCT02801110
18 New Approaches in MRI at 3T Dedicated to Targeting Subthalamic Nucleus on Parkinsonian Patients Not yet recruiting NCT02800460
19 Magnetic Resonance Imaging in the Diagnosis of Parkinsonian Syndromes Terminated NCT02445469
20 Parkinson's Disease Genetics Database Terminated NCT00855556

Search NIH Clinical Center for Parkinson Disease Susceptibility

Genetic Tests for Parkinson Disease Susceptibility

Genetic tests related to Parkinson Disease Susceptibility:

id Genetic test Affiliating Genes
1 Parkinson Disease Susceptibility 24 ADH1C ATXN2 GBA MT-TT UCHL1

Anatomical Context for Parkinson Disease Susceptibility

MalaCards organs/tissues related to Parkinson Disease Susceptibility:

39
Bone, Subthalamic Nucleus

Publications for Parkinson Disease Susceptibility

Articles related to Parkinson Disease Susceptibility:

id Title Authors Year
1
Functional polymorphisms of the MAO gene with Parkinson disease susceptibility: a meta-analysis. ( 25066260 )
2014
2
Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset. ( 19858467 )
2009
3
Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset. ( 18987351 )
2009
4
alpha-Synuclein and Parkinson disease susceptibility. ( 17872362 )
2007
5
A limited role for DJ1 in Parkinson disease susceptibility. ( 15304593 )
2004

Variations for Parkinson Disease Susceptibility

Expression for Parkinson Disease Susceptibility

Search GEO for disease gene expression data for Parkinson Disease Susceptibility.

Pathways for Parkinson Disease Susceptibility

Pathways related to Parkinson Disease Susceptibility according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.17 ATXN2 PARK7 SNCA UCHL1
2 11.74 ATP13A2 GSK3B LRRK2 MAPT PARK7 PTGS2
3 11.28 ATXN2 LRRK2 PARK7 SNCA UCHL1
4 10.84 PARK7 SNCA UCHL1

GO Terms for Parkinson Disease Susceptibility

Cellular components related to Parkinson Disease Susceptibility according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 9.65 ATP13A2 LRRK2 MAPT SNCA UCHL1
2 growth cone GO:0030426 9.61 LRRK2 MAPT SNCA
3 cell body GO:0044297 9.58 MAPT PARK7 RIT2
4 lysosome GO:0005764 9.55 ATP13A2 GBA HLA-DRA LRRK2 SNCA
5 postsynapse GO:0098794 9.5 GSK3B LRRK2 SNCA
6 inclusion body GO:0016234 9.46 LRRK2 SNCA
7 Wnt signalosome GO:1990909 9.37 GSK3B LRRK2
8 neuron projection GO:0043005 9.35 ATP13A2 LRRK2 PARK7 PTGS2 RIT2
9 axon GO:0030424 9.02 LRRK2 MAPT PARK7 SNCA UCHL1

Biological processes related to Parkinson Disease Susceptibility according to GeneCards Suite gene sharing:

(show all 27)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron apoptotic process GO:0043524 9.81 FGF20 PARK7 SNCA
2 mitochondrion organization GO:0007005 9.75 GBA LRRK2 PARK7
3 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.73 PARK7 PTGS2 SNCA
4 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 9.72 GBA GSK3B LRRK2
5 negative regulation of protein phosphorylation GO:0001933 9.71 LRRK2 PARK7 SNCA
6 regulation of macroautophagy GO:0016241 9.7 ATP13A2 GBA UCHL1
7 regulation of dopamine secretion GO:0014059 9.63 FGF20 SNCA
8 negative regulation of protein binding GO:0032091 9.63 GSK3B LRRK2 PARK7
9 neuron projection development GO:0031175 9.62 GBA MAPT
10 regulation of neuron death GO:1901214 9.62 LRRK2 SNCA
11 synaptic transmission, dopaminergic GO:0001963 9.61 PARK7 SNCA
12 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 9.61 LRRK2 PARK7
13 negative regulation of hydrogen peroxide-induced cell death GO:1903206 9.6 LRRK2 PARK7
14 microglial cell activation GO:0001774 9.59 MAPT SNCA
15 supramolecular fiber organization GO:0097435 9.58 MAPT SNCA
16 regulation of calcium-mediated signaling GO:0050848 9.57 MAPT RIT2
17 regulation of locomotion GO:0040012 9.51 LRRK2 SNCA
18 regulation of mitochondrial fission GO:0090140 9.49 LRRK2 MAPT
19 intracellular distribution of mitochondria GO:0048312 9.48 LRRK2 MAPT
20 axonal transport of mitochondrion GO:0019896 9.43 MAPT UCHL1
21 dopamine uptake involved in synaptic transmission GO:0051583 9.4 PARK7 SNCA
22 cellular response to manganese ion GO:0071287 9.37 ATP13A2 LRRK2
23 autophagosome organization GO:1905037 9.32 ATP13A2 GBA
24 positive regulation of neuron death GO:1901216 9.26 GSK3B MAPT
25 cellular response to oxidative stress GO:0034599 9.26 ATP13A2 LRRK2 PARK7 SNCA
26 regulation of lysosomal protein catabolic process GO:1905165 9.16 ATP13A2 GBA
27 negative regulation of neuron death GO:1901215 9.02 ATP13A2 GBA LRRK2 PARK7 SNCA

Molecular functions related to Parkinson Disease Susceptibility according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.46 MAPT PARK7 PTGS2 SNCA
2 cuprous ion binding GO:1903136 8.96 PARK7 SNCA
3 cupric ion binding GO:1903135 8.62 ATP13A2 PARK7

Sources for Parkinson Disease Susceptibility

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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