PD
MCID: PRK002
MIFTS: 93

Parkinson's Disease (PD) malady

Genetic diseases, Rare diseases, Neuronal diseases, Eye diseases, Metabolic diseases, Mental diseases categories
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Summaries for Parkinson's Disease

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MedlinePlus:33 Parkinson's disease (pd) is a type of movement disorder. it happens when nerve cells in the brain don't produce enough of a brain chemical called dopamine. sometimes it is genetic, but most cases do not seem to run in families. exposure to chemicals in the environment might play a role. symptoms begin gradually, often on one side of the body. later they affect both sides. they include trembling of hands, arms, legs, jaw and face stiffness of the arms, legs and trunk slowness of movement poor balance and coordination as symptoms get worse, people with the disease may have trouble walking, talking, or doing simple tasks. they may also have problems such as depression, sleep problems, or trouble chewing, swallowing, or speaking. there is no lab test for pd, so it can be difficult to diagnose. doctors use a medical history and a neurological examination to diagnose it. pd usually begins around age 60, but it can start earlier. it is more common in men than in women. there is no cure for pd. a variety of medicines sometimes help symptoms dramatically. surgery and deep brain stimulation (dbs) can help severe cases. with dbs, electrodes are surgically implanted in the brain. they send electrical pulses to stimulate the parts of the brain that control movement. nih: national institute of neurological disorders and stroke

MalaCards based summary: Parkinson's Disease, also known as parkinson disease, is related to dementia and multiple system atrophy. An important gene associated with Parkinson's Disease is MAPT (microtubule-associated protein tau), and among its related pathways are Alpha-synuclein signaling and CDK-mediated phosphorylation and removal of Cdc6. The drugs bromocriptine and 2-bromoergocryptine mesylate and the compounds tmao and rotenone have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and subthalamic nucleus, and related mouse phenotypes are growth/size/body and behavior/neurological.

Disease Ontology:8 A synucleinopathy that has material basis in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.

Genetics Home Reference:21 Parkinson disease is a progressive disorder of the nervous system. The disorder affects several regions of the brain, especially an area called the substantia nigra that controls balance and movement.

NIH Rare Diseases:42 Parkinson disease belongs to a group of conditions called movement disorders. the four main symptoms are tremor, or trembling in hands, arms, legs, jaw, or head; rigidity, or stiffness of the limbs and trunk; bradykinesia, or slowness of movement; and postural instability, or impaired balance. these symptoms usually begin gradually and worsen with time.  as they become more pronounced, patients may have difficulty walking, talking, or completing other simple tasks.  not everyone with one or more of these symptoms has parkinson disease, as the symptoms sometimes appear in other diseases as well. parkinson disease affects about 1 to 2 percent of people over the age of 60 years and the chance of developing parkinson disease increases as we age. although some parkinson disease cases appear to be hereditary, and a few can be traced to specific genetic mutations, most cases are sporadic and occur in people with no apparent history of the disorder in their family.  many researchers now believe that parkinson disease results from a combination of genetic susceptibility and exposure to one or more environmental factors that trigger the disease.  last updated: 10/3/2011

NINDS:43 Parkinson's disease (PD) belongs to a group of conditions called motor system disorders, which are the result of the loss of dopamine-producing brain cells. The four primary symptoms of PD are tremor, or trembling in hands, arms, legs, jaw, and face; rigidity, or stiffness of the limbs and trunk; bradykinesia, or slowness of movement; and postural instability, or impaired balance and coordination. As these symptoms become more pronounced, patients may have difficulty walking, talking, or completing other simple tasks. PD usually affects people over the age of 50.

Wikipedia:65 Parkinson\'s disease (PD, also known as idiopathic or primary parkinsonism, hypokinetic rigid... more...

Descriptions from OMIM:46 168600, 610297, 613643, 607060, 600116 606324, 605909, 260300, 607688, 168601, 612953, 556500, 605543 more

GeneReviews summary for parkinson-overview

Aliases & Classifications for Parkinson's Disease

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Parkinson's Disease, Aliases & Descriptions:

Name: Parkinson's Disease 30 8 42 21 43 33
Parkinson Disease 8 19 42 20 22 21 46 44 62
Primary Parkinsonism 42 21 62
Paralysis Agitans 8 42
 
Parkinsons Disease 10
Shaking Palsy 42
Pd 21


Classifications:



Related Diseases for Parkinson's Disease

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Diseases in the Parkinson's Disease family:

Lrrk2-Related Parkinson Disease Parkinson Disease Type 3
Parkinson Disease Type 9 Park7-Related Parkinson Disease
Snca-Related Parkinson Disease Htra2-Related Parkinson Disease
Vps35-Related Parkinson Disease Fbxo7-Related Parkinson Disease
Parkinson Disease 6, Early Onset Parkinson Disease 19, Juvenile-Onset
Parkinson Disease 10 Parkinson Disease, Late-Onset
Parkinson Disease 16 Parkinson Disease 13
Parkinson Disease 11 Parkinson Disease 18
Parkinson Disease 5 Parkinson Disease 4
Parkinson Disease 1 Parkinson Disease, Juvenile, Type 2
Parkinson Disease 8 Parkinson Disease 17
Parkinson Disease 20, Early-Onset Parkinson Disease 14
Parkinson Disease 12 Hereditary Parkinson Disease with Late-Onset

Diseases related to Parkinson's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 194)
idRelated DiseaseScoreTop Affiliating Genes
1dementia31.8LRRK2, TBP, MAPT, PARK2, PARK7, SNCA
2multiple system atrophy31.7LRRK2, SNCA, SLC6A3, MAPT, SNCB, PARK2
3essential tremor31.5PARK2, LRRK2, SNCA, SLC6A3
4rem sleep behavior disorder31.5SLC6A3, SNCA
5parkinson disease type 331.4LRRK2, PARK2, SNCA, MAPT, PARK7
6parkinson disease 131.4SNCA
7progressive supranuclear palsy31.4SLC6A3, MAPT
8lrrk2-related parkinson disease31.4LRRK2
9lewy body dementia31.3SNCA, SNCB
10lateral sclerosis31.2MAPT, SNCA
11frontotemporal dementia31.1SNCA, LRRK2, MAPT, PARK2
12breast cancer30.8PARK7, COMT, ADH1C, SNCA, MAPT, PARK2
13alzheimer's disease30.7NR4A2, PINK1, PARK2, PARK7, SNCA, SNCB
14tauopathy30.7LRRK2, PARK2, SNCA, MAPT, PARK7
15machado-joseph disease30.7TBP, SLC6A3, SNCA
16striatonigral degeneration30.7SLC6A3, SNCA
17spinocerebellar ataxia30.7MAPT, SNCA, TBP
18schizophrenia30.7COMT, NR4A2, SLC6A3, SNCA, TBP
19prion disease10.6PARK2, SNCA, SLC6A3, MAPT
20focal dystonia10.6PARK2
21memory impairment10.6SNCA, MAPT, SLC6A3
22oppositional defiant disorder10.6SLC6A3
23amyotrophic lateral sclerosis type 1410.6SLC6A3, SNCA, MAPT
24alcohol abuse10.6SLC6A3, ADH1C, COMT
25huntington's disease10.6SLC6A3, TBP, SNCA, MAPT, UCHL1
26niemann-pick disease type c110.6MAPT, SNCA
27movement disease10.6SNCA, LRRK2
28substance dependence10.6COMT, SLC6A3
29spinocerebellar ataxia type 1710.6SLC6A3, TBP
30conduct disorder10.6COMT, SLC6A3
31antisocial personality disorder10.6SLC6A3
32bipolar disorder10.6NR4A2, SLC6A3, COMT
33pendred syndrome10.5
34vascular dementia10.5MAPT, SNCA
35obsessive-compulsive disorder10.5SLC6A3, COMT
36creutzfeldt-jakob disease10.5SNCA, MAPT
37autosomal recessive juvenile parkinson disease10.5
38anxiety disorder10.5COMT, SLC6A3
39pheochromocytoma10.5SNCA, COMT, SLC6A3
40pathological gambling10.4
41pancreas disease10.4
42eating disorder10.4COMT, SLC6A3
43peritonitis10.4
44tremor10.4
45paralysis agitans, juvenile, of hunt10.4
46neuronitis10.4
47parkinson disease, late-onset10.4
48pick's disease10.3MAPT, SNCA
49parkinson disease type 910.3
50enlarged vestibular aqueduct10.3

Graphical network of the top 20 diseases related to Parkinson's Disease:



Diseases related to parkinson's disease

Symptoms for Parkinson's Disease

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Clinical features from OMIM:

168600, 610297, 613643, 607060, 600116, 606324, 605909, 260300, 607688, 168601 612953, 556500, 605543 more

Drugs & Therapeutics for Parkinson's Disease

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Drug clinical trials:

Search ClinicalTrials for Parkinson's Disease

Search NIH Clinical Center for Parkinson's Disease

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Parkinson's Disease cell therapies at LifeMap Discovery.

Genetic Tests for Parkinson's Disease

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Genetic tests related to Parkinson's Disease:

id Genetic test Affiliating Genes
1 Parkinson Disease20 VPS35
2 Parkinson Disease, Susceptibility to20 MT-TT
3 Parkinson Disease Multi-Gene Panels20
4 Parkinson's Disease22

Anatomical Context for Parkinson's Disease

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MalaCards organs/tissues related to Parkinson's Disease:

32
Brain, Testes, Subthalamic nucleus, Bone, Cortex, Eye, Globus pallidus, Heart, Colon, Liver, Endothelial, Olfactory bulb, Thalamus, Amygdala, Whole blood, Cerebellum, Retina, Skeletal muscle, Breast, Skin, Prostate, Caudate nucleus, Medulla oblongata, Bone marrow, Spinal cord, Lung, Monocytes, T cells, Prefrontal cortex, Hypothalamus, Neutrophil

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Parkinson's Disease:
id TissueAnatomical CompartmentCell Relevance
1 BrainSubstantia Nigra pars CompactaAdult Dopaminergic Neurons Potential therapeutic candidate, affected by disease
2 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
3 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Parkinson's Disease or affiliated genes

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MGI Mouse Phenotypes related to Parkinson's Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537810.5NR4A2, TBP, PARK7, PINK1, PARK2, SLC6A3
2MP:000538610.5SLC6A3, NR4A2, UCHL1, MAPT, GIGYF2, SNCA
3MP:000363110.5MAPT, FGF20, SLC6A3, NR4A2, UCHL1, PINK1
4MP:001076810.5LRRK2, PARK2, SLC6A3, SNCA, TBP, NR4A2
5MP:000301210.4SNCB, SNCA, LRRK2, PINK1, MAPT, TBP
6MP:000537610.4SLC6A3, TBP, PARK2, NR4A2, LRRK2, PINK1
7MP:001077110.4UCHL1, MAPT, PARK2, LRRK2, SLC6A3, SNCA
8MP:000539410.3PINK1, SNCA, MAPT, SLC6A3
9MP:000538410.1NR4A2, SLC6A3, PINK1, PARK2, LRRK2, PARK7

Publications for Parkinson's Disease

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Articles related to Parkinson's Disease:

(show top 50)    (show all 4050)
idTitleAuthorsYear
1
Endothelial dysfunction and hyperhomocysteinemia in Parkinson's disease: flow-mediated dilation study. (25154960)
2014
2
The Relative Contribution of Physical and Cognitive Fall Risk Factors in People With Parkinson's Disease: A Large Prospective Cohort Study. (24243915)
2013
3
GAK rs1564282 and DGKQ rs11248060 increase the risk for Parkinson's disease in a Chinese population. (23618683)
2013
4
Referral to rehabilitation in Parkinson's disease: who, when and to what end? (24347018)
2013
5
MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein. (23125283)
2013
6
Monitoring mitochondrial dynamics and complex I dysfunction in neurons: implications for Parkinson's disease. (24256264)
2013
7
Differentiating symptomatic Parkin mutations carriers from patients with idiopathic Parkinson's disease: contribution of automated segmentation neuroimaging method. (22445249)
2012
8
I+-Synuclein mRNA and soluble I+-synuclein protein levels in post-mortem brain from patients with Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease. (22560502)
2012
9
Instability of syllable repetition in patients with spinocerebellar ataxia and Parkinson's disease. (22109901)
2012
10
Parkinson's disease involves autophagy and abnormal distribution of cathepsin L. (21134415)
2011
11
Catechol-O-methyltransferase val158met and cognitive function in Parkinson's disease. (20878993)
2010
12
Tremor in Parkinson's disease is not associated with the DRD3 Ser9Gly polymorphism. (20434388)
2010
13
Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease. (18973248)
2009
14
Haplotype analysis of the engrailed-2 gene in young-onset Parkinson's disease. (19270442)
2009
15
Impact of newer pharmacological treatments on quality of life in patients with Parkinson's disease. (18547126)
2008
16
Can overexpression of parkin provide a novel strategy for neuroprotection in Parkinson's disease? (18538324)
2008
17
Nitrated alpha-synuclein-activated microglial profiling for Parkinson's disease. (18036154)
2008
18
COMT inhibition with tolcapone in the treatment algorithm of patients with Parkinson's disease (PD): relevance for motor and non-motor features. (18728767)
2008
19
Superoxide dismutase overexpression protects dopaminergic neurons in a Drosophila model of Parkinson's disease. (18243716)
2008
20
Human neural progenitor cells over-expressing IGF-1 protect dopamine neurons and restore function in a rat model of Parkinson's disease. (18061591)
2008
21
Fibroblast growth factor 20 gene and Parkinson's disease in the Japanese population. (17515805)
2007
22
Genetic polymorphism of the angiotensin converting enzyme and L-dopa-induced adverse effects in Parkinson's disease. (17196621)
2007
23
Management of motor complications in advanced Parkinson's disease. (18175400)
2007
24
No association between Parkinson's disease and three polymorphisms in the eNOS, nNOS, and iNOS genes. (17174475)
2007
25
Merging mouse transcriptome analyses with Parkinson's disease linkage studies. (17522092)
2007
26
Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease. (16914382)
2006
27
Analysis of the polymorphic prion protein gene codon 129 in idiopathic Parkinson's disease. (15997418)
2006
28
N-acetyltransferase 2 (NAT2) gene polymorphisms in Parkinson's disease. (16571112)
2006
29
Imaging in Parkinson's disease: the role of monoamines in behavior. (16581032)
2006
30
Leucine-rich repeat kinase 2: a new player with a familiar theme for Parkinson's disease pathogenesis. (16275903)
2005
31
A comparison of degeneration in motor thalamus and cortex between progressive supranuclear palsy and Parkinson's disease. (16014651)
2005
32
Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis. (15944198)
2005
33
G2019S dardarin substitution is a common cause of Parkinson's disease in a Portuguese cohort. (16149095)
2005
34
A study on the relationship between polymorphism of human NAD(P)H: quinone oxidoreductase and Parkinson's disease in Chinese]. (15079792)
2004
35
Chemokines (RANTES and MCP-1) and chemokine-receptors (CCR2 and CCR5) gene polymorphisms in Alzheimer's and Parkinson's disease. (15488313)
2004
36
Progressive supranuclear palsy and Parkinson's disease in a family with a new mutation in the tau gene. (14991829)
2004
37
NURR1 promoter polymorphisms: Parkinson's disease, schizophrenia, and personality traits. (12815740)
2003
38
Striatal dopaminergic denervation in early and late onset Parkinson's disease assessed by PET and the tracer [11C]FECIT: preliminary findings in one patient with autosomal recessive parkinsonism (Park2). (12548339)
2002
39
Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease. (12351575)
2002
40
Downregulation of striatal dopamine D2 receptors in advanced Parkinson's disease contributes to the development of motor fluctuation. (11844900)
2002
41
The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. (12408865)
2002
42
Subthalamic GAD gene therapy in a Parkinson's disease rat model. (12376704)
2002
43
Plasticity of afferent fibers to striatal neurons bearing D1 dopamine receptors in Parkinson's disease. (11391736)
2001
44
Mitochondrial dysfunction in Parkinson's disease. (9749580)
1998
45
Mechanism of action of dopaminergic agents in Parkinson's disease. (9633680)
1998
46
A chronic MPTP model reproducing the slow evolution of Parkinson's disease: evolution of motor symptoms in the monkey. (9359593)
1997
47
Differential changes in neurochemical markers of striatal dopamine nerve terminals in idiopathic Parkinson's disease. (8797470)
1996
48
Platelet MAO activities and MAO-B protein concentrations in Parkinson's disease and controls. (8584677)
1995
49
An integrated approach to patient management in Parkinson's disease. (1350053)
1992
50
Serum levels of zinc and copper in patients with Parkinson's disease. (1469436)
1992

Variations for Parkinson's Disease

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UniProtKB/Swiss-Prot genetic disease variations for Parkinson's Disease:

64
id Symbol AA change Variation ID SNP ID
1PARK2p.Cys253TyrVAR_019749
2PARK2p.Arg256CysVAR_019750rs150562946
3PARK2p.Arg275TrpVAR_019752rs34424986
4PARK2p.Asp280AsnVAR_019753

Clinvar genetic disease variations for Parkinson's Disease:

6
id Gene Name Type Significance SNP ID Assembly Location
1GLUD2NM_012084.3(GLUD2): c.1492T> G (p.Ser498Ala)single nucleotide variantPathogenicrs9697983GRCh37Chr X, 120183030: 120183030
2DNAJC13NM_015268.3(DNAJC13): c.2564A> G (p.Asn855Ser)single nucleotide variantPathogenicrs387907571GRCh37Chr 3, 132196839: 132196839
3MT-ND1m.3397A> Gsingle nucleotide variantPathogenicrs199476120GRCh37Chr MT, 3397: 3397

Expression for genes affiliated with Parkinson's Disease

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Expression patterns in normal tissues for genes affiliated with Parkinson's Disease

Search GEO for disease gene expression data for Parkinson's Disease.

Pathways for genes affiliated with Parkinson's Disease

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Pathways related to Parkinson's Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4SNCA, SLC6A3, UCHL1, PARK7, PARK2
2
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I60
10.4SLC6A3, UCHL1, MAPT, PINK1, PARK2, PARK7
310.4PARK7, PINK1, LRRK2, PARK2, SNCA, UCHL1
4
Show member pathways
10.4TBP, UCHL1, SNCA, MT-ND1, PARK7, PARK2
510.4UCHL1, PINK1, ATP13A2, MAPT, SNCB, SNCA

Compounds for genes affiliated with Parkinson's Disease

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Compounds related to Parkinson's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1tmao4410.9SNCA, MAPT, TBP
2rotenone4410.9SLC6A3, MT-ND1, SNCA, PARK2, PARK7
3methionine4410.9MAPT, COMT, SNCA, MT-ND1, PINK1, PARK7
4thioflavin4410.9MAPT, SNCA
5choline44 24 1112.9SLC6A3, COMT, SNCA, ADH1C, MAPT
61 methyl 4 phenylpyridinium4410.9SLC6A3, PARK2, SNCA
71-benzyl-1,2,3,4-tetrahydroisoquinoline4410.9SNCA, SLC6A3
8mptp4410.9PARK2, SLC6A3, SNCA, COMT
9alanine4410.9SLC6A3, PARK2, MT-ND1, SNCA, MAPT, TBP
10valine4410.8COMT, SNCA, MAPT, SLC6A3, MT-ND1
11proline4410.8MAPT, MT-ND1, TBP, COMT, PARK2
12thioflavine s4410.8SNCA, MAPT
136-hydroxydopamine4410.8PARK2, COMT, SNCA, SLC6A3, NR4A2, PARK7
14selegiline44 1111.8SNCA, COMT, SLC6A3
15levodopa44 1111.8PINK1, PARK7, PARK2, SNCA, COMT, SLC6A3
166-(18f)fluoro-l-dopa4410.8PARK2, COMT
17apomorphine28 44 1112.8SLC6A3, SNCA, COMT
18iron44 2411.8PARK2, MT-ND1, TBP, SNCA, SNCB
19h2o24410.8MAPT, SNCA, SLC6A3, SNCB, PARK2, PARK7
20cysteine4410.8TBP, PARK2, SNCA, PARK7, COMT, MAPT
213,4-Dihydroxyphenylglycol2410.8ADH1C, COMT
22lysine4410.8SNCA, TBP, PARK7, PARK2, UCHL1
23serine4410.8SNCA, PINK1, NR4A2, PARK2, SLC6A3, TBP
24methamphetamine44 50 1112.8SNCA, COMT, SLC6A3
25dopamine44 28 24 1113.8PARK2, NR4A2, UCHL1, SNCA, MAPT, COMT
26lactacystin4410.8MAPT, SNCA, PARK2
27testosterone44 61 24 1113.8MAPT, COMT, SNCA, PARK7, PARK2
28phosphocellulose4410.8TBP, MAPT
29sodium dodecylsulfate4410.8SNCA, MAPT, TBP
30nmda44 2811.8PARK2, COMT, MAPT, SLC6A3
31carbidopa44 2811.8SLC6A3, COMT
32catecholamine4410.8SNCA, PARK2, COMT
33norepinephrine44 24 1112.8COMT, SNCA, SLC6A3, NR4A2
34dopac4410.8PARK2, COMT
35threonine4410.7NR4A2, MAPT, MT-ND1, PARK2, PINK1
36glutamine4410.7PARK2, SNCA, MAPT, TBP
37methylphenidate44 50 1112.7COMT, SLC6A3
38glutamate4410.7COMT, MAPT, GLUD2, SLC6A3, SNCA
39cocaine44 1111.7SLC6A3, SNCA, COMT
40mg 13244 6111.7MAPT, SNCA, PARK2
41maoa4410.7SLC6A3, COMT
42superoxide44 2411.6UCHL1, PARK2, SNCB, PARK7
43formaldehyde44 2411.6TBP, MAPT, ADH1C
44pramipexole44 28 50 1113.6COMT, SLC6A3
45trifluoroethanol44 1111.6MAPT, ADH1C
46fluvoxamine44 50 1112.5COMT, SLC6A3
47tyramine44 28 2412.4COMT, SLC6A3
48heroin44 50 1112.4SLC6A3, COMT
49venlafaxine44 50 24 1113.3SLC6A3, COMT
50nicotine44 28 50 1113.1SLC6A3, MAPT, COMT

GO Terms for genes affiliated with Parkinson's Disease

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Cellular components related to Parkinson's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:03042410.6SNCA, SLC6A3, UCHL1, LRRK2, MAPT
2mitochondrionGO:00573910.5SNCA, GLUD2, PARK7, PARK2, LRRK2, PINK1
3inclusion bodyGO:01623410.5LRRK2, SNCA
4cytosolGO:00582910.4PARK2, PARK7, ADH1C, LRRK2, COMT, MAPT
5neuronal cell bodyGO:04302510.4SNCB, UCHL1, SLC6A3, LRRK2
6cytoplasmGO:00573710.3GLUD2, TBP, NR4A2, SNCB, UCHL1, SNCA
7growth coneGO:03042610.1MAPT, SNCA, SNCB

Biological processes related to Parkinson's Disease according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1dopamine uptake involved in synaptic transmissionGO:05158310.7SNCA, PARK7
2adult locomotory behaviorGO:00834410.7SNCA, PARK7, GIGYF2, NR4A2
3dopamine biosynthetic processGO:04241610.7SLC6A3, SNCA, NR4A2
4negative regulation of neuron apoptotic processGO:04352410.7SNCA, PARK7, SNCB, PINK1, NR4A2, PARK2
5negative regulation of dopamine metabolic processGO:04596310.7COMT, SNCA
6cell deathGO:00821910.7PARK7, PINK1, ATP13A2, VPS35, PARK2, GIGYF2
7dopamine catabolic processGO:04242010.7COMT, SLC6A3
8regulation of locomotionGO:04001210.7LRRK2, SNCA
9mitochondrion degradationGO:00042210.7PARK2, PINK1
10regulation of dopamine metabolic processGO:04205310.6SLC6A3, NR4A2
11neuron deathGO:07099710.6PARK2, LRRK2
12neurotransmitter biosynthetic processGO:04213610.6COMT, SLC6A3
13regulation of autophagyGO:01050610.5MAPT, PARK2
14negative regulation of cell deathGO:06054810.5PARK7, PARK2
15oxidation-reduction processGO:05511410.5PARK7, SNCA, GLUD2
16cellular response to oxidative stressGO:03459910.4NR4A2, SNCA
17synapse organizationGO:05080810.1SNCA, SNCB

Molecular functions related to Parkinson's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-tubulin bindingGO:04848710.4SNCB, SNCA
2protein bindingGO:00551510.4PARK7, LRRK2, VPS35, PARK2, PINK1, SNCA
3alpha-tubulin bindingGO:04301410.3SNCB, SNCA
4magnesium ion bindingGO:00028710.1COMT, PINK1, SNCA

Products for genes affiliated with Parkinson's Disease

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Sources for Parkinson's Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet