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PD
MCID: PRK002
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Parkinson's Disease malady |
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24 drugs, 986 genes, 33 tissues, 981 related diseases, 30 phenotypes, 2730 articles, clinical trials, genetic tests.
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Sources: 6Disease Ontology, 23MedlinePlus, 31NINDS, 15GeneReviews, 44Wikipedia, 33OMIM, 22MalaCards See all sources Export this MalaCard |
MedlinePlus: Parkinson's disease is a disorder that affects nerve cells, or neurons, in a part of the brain that controls muscle movement. in parkinson's, neurons that make a chemical called dopamine die or do not work properly. dopamine normally sends signals that help coordinate your movements. no one knows what damages these cells. symptoms of parkinson's disease may include
trembling of hands, arms, legs, jaw and face
stiffness of the arms, legs and trunk
slowness of movement
poor balance and coordination
as symptoms get worse, people with the disease may have trouble walking, talking or doing simple tasks. they may also have problems such as depression, sleep problems or trouble chewing, swallowing or speaking.
parkinson's usually begins around age 60, but it can start earlier. it is more common in men than in women. there is no cure for parkinson's disease. a variety of medicines sometimes help symptoms dramatically.23
MalaCards: Parkinson's Disease, also known as parkinson disease, is related to neuronitis and carcinoma. An important gene associated with Parkinson's Disease is LRRK2 (leucine-rich repeat kinase 2), and among its related pathways are Metabolic pathways and Parkinsons disease. The drugs bromocriptine and pergolide and the compounds lipid and estrogen have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and liver, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological. Disease Ontology: A neurodegenerative disease that has material basis in degeneration of the central nervous system that often impairs the sufferer's motor skills, speech, and other functions.6 NINDS: Parkinson's disease (PD) belongs to a group of conditions called motor system disorders, which are the result of the loss of dopamine-producing brain cells. The four primary symptoms of PD are tremor, or trembling in hands, arms, legs, jaw, and face; rigidity, or stiffness of the limbs and trunk; bradykinesia, or slowness of movement; and postural instability, or impaired balance and coordination. As these symptoms become more pronounced, patients may have difficulty walking, talking, or completing other simple tasks. PD usually affects people over the age of 50.31 Genetics Home Reference: Parkinson disease is a progressive disorder of the nervous system. The disorder affects several regions of the brain, especially an area called the substantia nigra that controls balance and movement.17 Wikipedia: Parkinson\'s disease (also known as Parkinson disease, Parkinson\'s, idiopathic parkinsonism, primary...44 more... OMIM: 168600 GeneReviews summary for parkinson-overview |
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Sources: 6Disease Ontology, 17Genetics Home Reference, 31NINDS, 23MedlinePlus, 43UMLS, 7diseasecard, 15GeneReviews, 16GeneTests, 33OMIM, 32Novoseek , 8DISEASES, 40SNOMED-CT, 19ICD9CM, 27NCIt, 24MeSH See all sources |
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Sources: 33OMIM See all sources |
Clinical features from OMIM: 168600
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Sources: 4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 21LifeMap Discovery™, 43UMLS, 28NDF-RT See all sources |
Approved drugs:Search CenterWatch for parkinson's disease Drug clinical trials:Search ClinicalTrials for parkinson's disease Search NIH Clinical Center for parkinson's disease Search CenterWatch for parkinson's disease Inferred drug relations via UMLS/NDF-RT:43 28 amantadine, amantadine hydrochloride, benztropine, benztropine mesylate, biperiden, biperiden hydrochloride, biperiden lactate, bromocriptine, bromocriptine mesylate, cabergoline, carbidopa, entacapone, levodopa, pergolide, pergolide mesylate, pramipexole, pramipexole dihydrochloride, ropinirole, ropinirole hydrochloride, selegiline, selegiline hydrochloride, tolcapone, trihexyphenidyl, trihexyphenidyl hydrochlorideCell-based therapeutics: The database of embryonic development, stem cell research and regenerative medicine Stem-Cell-Based therapeutic approaches for parkinson's disease:
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Sources: 16GeneTests See all sources |
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Sources: 21LifeMap Discovery™, 22MalaCards See all sources |
MalaCards organs/tissues related to parkinson's disease:22Brain, Skin, Liver, Lung, Bone marrow, Whole blood, Cortex, Cerebellum, Skeletal muscle, Small intestine, Adrenal gland, Prostate, Monocytes, Nk cells, T cells, B cells, Endothelial, Fetal brain, Prefrontal cortex, Globus pallidus, Olfactory bulb, Thalamus, Hypothalamus, Subthalamic nucleus, Caudate nucleus, Amygdala, Pons, Medulla oblongata, Cardiac myocytes, Fetal liver, Fetal lung, Adrenal cortex The database of embryonic development, stem cell research and regenerative medicine Embryonic and adult cells/anatomical compartments related to parkinson's disease:
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Brain -> |
Sources: 25MGI See all sources |
MGI Mouse Phenotypes related to parkinson's disease:25 (show all 30)
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Sources: 35PubMed See all sources |
Articles related to parkinson's disease:(show top 50) (show all 2730)
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Sources: 1BioGPS See all sources |
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Sources: 20KEGG, 3Cell Signaling Technology, 38Reactome, 36QIAGEN, 41Thomson Reuters, 10EMD Millipore See all sources |
Pathways related to parkinson's disease according to GeneDecks:(show top 50) (show all 236)
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Sources: 32Novoseek , 42Tocris Bioscience, 34PharmGKB, 9DrugBank, 18HMDB See all sources |
Compounds related to parkinson's disease according to GeneDecks:(show top 50) (show all 602)
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Sources: 12Gene Ontology See all sources |
Cellular components related to parkinson's disease according to GeneDecks:(show all 19)
Biological processes related to parkinson's disease according to GeneDecks:(show top 50) (show all 62)
Molecular functions related to parkinson's disease according to GeneDecks:(show all 15)
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