Aliases & Classifications for Parotitis

MalaCards integrated aliases for Parotitis:

Name: Parotitis 12 51 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10301
ICD10 32 K11.2
MeSH 41 D010309
NCIt 46 C114281
UMLS 69 C0030583

Summaries for Parotitis

Disease Ontology : 12 A parotid disease characterized by the inflammation of one or both parotid glands.

MalaCards based summary : Parotitis is related to meningoencephalitis and appendicitis. An important gene associated with Parotitis is SPINK1 (Serine Peptidase Inhibitor, Kazal Type 1), and among its related pathways/superpathways are Bladder cancer and AGE/RAGE pathway. The drugs Isoniazid and Pyrazinamide have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, thyroid and brain, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 72 Parotitis is an inflammation of one or both parotid glands, the major salivary glands located on either... more...

Related Diseases for Parotitis

Diseases in the Parotitis family:

Parotitis, Juvenile Recurrent

Diseases related to Parotitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 212)
# Related Disease Score Top Affiliating Genes
1 meningoencephalitis 30.1 ALB CD79A
2 appendicitis 29.4 ALB MMP9
3 otitis media 28.7 ALB CD79A
4 parotitis, juvenile recurrent 11.9
5 mumps 10.3
6 chronic follicular conjunctivitis 10.3 CD79A MMP9
7 blepharochalasis 10.3 CD79A MMP9
8 lymphocytic colitis 10.3 CD79A MMP9
9 extracranial arteriovenous malformation 10.2 MMP2 MMP9
10 focal myositis 10.2 MMP2 MMP9
11 spastic entropion 10.2 MMP2 MMP9
12 lentigo maligna melanoma 10.2 MMP2 MMP9
13 villous adenocarcinoma 10.2 MMP2 MMP9
14 psammomatous meningioma 10.2 MMP2 MMP9
15 acute transverse myelitis 10.2 MMP2 MMP9
16 senile ectropion 10.2 MMP2 MMP9
17 periodontosis 10.2 CD79A MMP9
18 internal hemorrhoid 10.2 MMP2 MMP9
19 light chain deposition disease 10.2 MMP2 MMP9
20 conjunctival nevus 10.2 MMP2 MMP9
21 microcystic meningioma 10.2 MMP2 MMP9
22 adenomyosis 10.2 MMP2 MMP9
23 hypercementosis 10.2 MMP2 MMP9
24 corneal ulcer 10.2 MMP2 MMP9
25 sorsby fundus dystrophy 10.2 MMP2 MMP9
26 nasal cavity squamous cell carcinoma 10.2 MMP2 MMP9
27 cork-handlers' disease 10.2 ALB CD79A
28 pharynx cancer 10.2 CD79A MMP9
29 odontogenic myxoma 10.2 MMP2 MMP9
30 ostertagiasis 10.2 ALB CD79A
31 transverse myelitis 10.2 MMP2 MMP9
32 dermatitis, atopic, 3 10.2 ALB CD79A
33 lung giant cell carcinoma 10.2 MMP2 MMP9
34 orthostatic proteinuria 10.2 ALB CD79A
35 marasmus 10.2 ALB CD79A
36 pelvic organ prolapse 10.2 MMP2 MMP9
37 yellow nail syndrome 10.2 ALB CD79A
38 chronic graft versus host disease 10.2 ALB CD79A
39 diffuse glomerulonephritis 10.2 ALB CD79A
40 back pain 10.2 G6PD MMP9
41 focal dermal hypoplasia 10.2 ALB CD79A
42 hypertensive heart disease 10.2 MMP2 MMP9
43 aortic aneurysm, familial thoracic 1 10.2 MMP2 MMP9
44 non-secretory myeloma 10.2 ALB CD79A
45 inguinal hernia 10.2 MMP2 MMP9
46 hypersensitivity reaction type iii disease 10.2 ALB CD79A
47 protein-losing enteropathy 10.2 ALB CD79A
48 pneumothorax 10.2 MMP2 MMP9
49 ulcerative stomatitis 10.1 ALB CD79A
50 pneumocystosis 10.1 ALB CD79A

Graphical network of the top 20 diseases related to Parotitis:



Diseases related to Parotitis

Symptoms & Phenotypes for Parotitis

MGI Mouse Phenotypes related to Parotitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.63 MMP9 SPINK1 CD79A G6PD LTF MMP2
2 homeostasis/metabolism MP:0005376 9.5 SPINK1 ALB CD79A G6PD LTF MMP2
3 neoplasm MP:0002006 9.02 ALB CD79A LTF MMP2 MMP9

Drugs & Therapeutics for Parotitis

Drugs for Parotitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isoniazid Approved, Investigational Phase 4 54-85-3 3767
2
Pyrazinamide Approved, Investigational Phase 4 98-96-4 1046
3
Rifampin Approved Phase 4 13292-46-1 5381226 5458213
4 Anti-Bacterial Agents Phase 4,Phase 1,Phase 2
5 Antibiotics, Antitubercular Phase 4,Phase 1,Phase 2
6 Anti-Infective Agents Phase 4,Phase 1,Phase 2
7 Antimetabolites Phase 4,Phase 1,Phase 2
8 Antitubercular Agents Phase 4,Phase 1,Phase 2
9 Cytochrome P-450 CYP3A Inducers Phase 4
10 Hypolipidemic Agents Phase 4
11 Lipid Regulating Agents Phase 4
12 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 1,Phase 2
13 Vaccines Phase 4,Phase 3,Phase 2,Phase 1
14 Antibodies Phase 4,Phase 1,Phase 2
15 Immunoglobulins Phase 4,Phase 1,Phase 2
16 Heptavalent Pneumococcal Conjugate Vaccine Phase 3
17
Busulfan Approved, Investigational Phase 1, Phase 2 55-98-1 2478
18
Fludarabine Approved Phase 1, Phase 2 21679-14-1, 75607-67-9 30751
19
Lenograstim Approved, Investigational Phase 1, Phase 2 135968-09-1
20
Methotrexate Approved Phase 1, Phase 2 1959-05-2, 59-05-2 126941
21
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
22
Mycophenolate mofetil Approved, Investigational Phase 1, Phase 2 128794-94-5 5281078
23
Mycophenolic acid Approved Phase 1, Phase 2 24280-93-1 446541
24
Phenytoin Approved, Vet_approved Phase 1, Phase 2 57-41-0 1775
25
Vidarabine Approved, Investigational Phase 1, Phase 2 24356-66-9 21704 32326
26
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
27
leucovorin Approved, Nutraceutical Phase 1, Phase 2 58-05-9 143 6006
28 Adjuvants, Immunologic Phase 1, Phase 2
29 Alkylating Agents Phase 1, Phase 2
30 Anticonvulsants Phase 1, Phase 2
31 Antifungal Agents Phase 1, Phase 2
32 Antimetabolites, Antineoplastic Phase 1, Phase 2
33 Antirheumatic Agents Phase 1, Phase 2
34 Antiviral Agents Phase 1, Phase 2
35 Calcineurin Inhibitors Phase 1, Phase 2
36 Calcium, Dietary Phase 1, Phase 2
37 Cyclosporins Phase 1, Phase 2
38 Dermatologic Agents Phase 1, Phase 2
39 Disinfectants Phase 1, Phase 2
40 Diuretics, Potassium Sparing Phase 1, Phase 2
41 Folic Acid Antagonists Phase 1, Phase 2
42 Hormones Phase 1, Phase 2
43 Immunosuppressive Agents Phase 1, Phase 2
44 Interleukin-2 Phase 1, Phase 2
45 Interleukin-4 Phase 1, Phase 2
46 Krestin Phase 1, Phase 2
47 Mitogens Phase 1, Phase 2
48 Sodium Channel Blockers Phase 1, Phase 2
49 Vitamin B Complex Phase 1, Phase 2
50 Folate Nutraceutical Phase 1, Phase 2

Interventional clinical trials:

(show all 30)

# Name Status NCT ID Phase Drugs
1 A Randomized Trial of Three Regimens to Prevent Tuberculosis in HIV-Infected Patients With Anergy Completed NCT00402610 Phase 4 isoniazid, rifampin + isoniazid, rifampin + pyrazinamide or not treatment
2 Immunogenicity and Safety of Japanese Encephalitis Vaccine When Given With Measles-Mumps-Rubella Vaccine Completed NCT02880865 Phase 4
3 Comparative Study of the Immunogenicity of MMR (Measles, Mumps and Rubella) Single Dose and Multidose Presentations Completed NCT01777529 Phase 4
4 Measles, Mumps, and Rubella (MMR) Immunity in College Students Completed NCT00962819 Phase 4
5 Immunogenicity and Safety of Hepatitis A Vaccine Given at the Same Time of Measles, Mumps, Rubella Combined Vaccine Completed NCT00313950 Phase 4
6 Immunogenicity and Safety of Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases Completed NCT00126997 Phase 4
7 Safety and Immunogenicity Study of Live Attenuated Mumps Vaccines in Healthy Infants Completed NCT02692599 Phase 3
8 Safety and Immunogenicity Study of GlaxoSmithKline (GSK) Biologicals' Measles, Mumps and Rubella (MMR) Vaccine (209762) Compared to Merck & Co., Inc.'s MMR Vaccine in Healthy Children 12 to 15 Months of Age Completed NCT02184572 Phase 3
9 Immunogenicity and Safety of GSK Biologicals' Combined Measles-mumps-rubella Vaccine in Volunteers, Seven Years of Age and Older Completed NCT02058563 Phase 3
10 Study of Immunogenicity, Reactogenicity and Safety of the Combined Measles, Mumps and Rubella Vaccine Produced by Bio-Manguinhos/Fiocruz in Children 12-15 Months of Age, Followed by Tetraviral Vaccine in Children 15-18 Months. Completed NCT01991899 Phase 3
11 Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Combined Measles-mumps-rubella (MMR) Vaccine in Children in Their Second Year of Life Completed NCT01681992 Phase 3
12 Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Combined Measles-mumps-rubella (MMR) Vaccine in Subjects Four to Six Years of Age Completed NCT01621802 Phase 3
13 Safety, Tolerability, and Immunogenicity of Measles, Mumps, Rubella, and Varicella (MMRV) Vaccine Made With an Alternative Manufacturing Process (AMP)(V221-027) Completed NCT01536405 Phase 3
14 Study of Japanese Encephalitis Chimeric Virus Vaccine Given With Measles-Mumps-Rubella Vaccine in Taiwanese Toddlers Completed NCT01188343 Phase 3
15 Comparison of GSK Measles-mumps-rubella-varicella (MMRV) Vaccine Versus PriorixTM Completed NCT00969436 Phase 3
16 Immunogenicity & Safety Study of GSK Biologicals' Combined Measles-mumps-rubella-varicella Vaccine 208136 Completed NCT00751348 Phase 3
17 Long-term Follow-up on Immunogenicity & Safety of Measles-Mumps-Rubella-Varicella (MMRV) Combined Vaccine Completed NCT00406211 Phase 3
18 Immunogenicity and Safety of a Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases Completed NCT00127023 Phase 3
19 Immunogenicity and Safety of a Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases Completed NCT00127010 Phase 3
20 Study to Evaluate Frozen Versus Refrigerated MMRV (Combined Measles, Mumps, Rubella, and Varicella) Investigational Vaccine (V221-016) Completed NCT00092430 Phase 3
21 A Study of An Approved Vaccine at Mumps Expiry Potency in Healthy Children 12 to 18 Months of Age (V205C-007)(COMPLETED) Completed NCT00092391 Phase 3
22 Busulfan, Fludarabine, and Total-Body Irradiation in Treating Patients Who Are Undergoing a Donor Stem Cell Transplant for Hematologic Cancer Completed NCT00245037 Phase 1, Phase 2 busulfan;cyclosporine;fludarabine phosphate;mycophenolate mofetil;Granulocyte colony-stimulating factor (G-CSF);Phenytoin;Methotrexate
23 Immunogenicity, Safety of Measles-mumps-rubella-varicella Vaccine (MeMuRu-OKA) Compared to Priorix™ Given With Varilrix™ Completed NCT00353288 Phase 2
24 Immunogenicity, Safety of Measles-mumps-rubella-varicella Vaccine (MeMuRu-OKA) Compared to Priorix™ Given With Varilrix™ Completed NCT00352898 Phase 2
25 Phase II of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants Active, not recruiting NCT03133923 Phase 2
26 A Phase I, Safety Study of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Chinese Children Completed NCT01712906 Phase 1
27 Serological Study in Children 12 to 23 Months Vaccinated With MMR (Measles, Mumps and Rubella) Completed NCT01874457
28 Making Decisions About the Measles-Mumps-Rubella Vaccine Completed NCT01369394
29 Gender and Opioid Consumption Not yet recruiting NCT03006627 postoperative morphine
30 Safety Study of Measles-Mumps-Rubella-Varicella (MMRV) Vaccine, Priorix-Tetra™ in Children Living in the Philippines Withdrawn NCT01738841

Search NIH Clinical Center for Parotitis

Cochrane evidence based reviews: parotitis

Genetic Tests for Parotitis

Anatomical Context for Parotitis

MalaCards organs/tissues related to Parotitis:

38
Salivary Gland, Thyroid, Brain, Lung, Breast, Myeloid, Kidney

Publications for Parotitis

Articles related to Parotitis:

(show top 50) (show all 571)
# Title Authors Year
1
Neonatal Parotitis. ( 29428272 )
2018
2
Sialoendoscopy for treatment of juvenile recurrent parotitis: The Brescia experience. ( 29447807 )
2018
3
<i>Mycobacterium mageritense</i> Parotitis in an Immunocompetent Adult. ( 29434394 )
2018
4
Sialendoscopy in treatment of adult chronic recurrent parotitis without sialolithiasis. ( 29290052 )
2018
5
Challenging Case of Parotitis: A Comprehensive Approach. ( 29181524 )
2017
6
Chronic Recurrent Non-specific Parotitis: A Case Report and Review. ( 28458496 )
2017
7
Magnetic Resonance Imaging Findings of Mumps Meningoencephalitis with Bilateral Hippocampal Lesions without Preceding Acute Parotitis: A Case Report. ( 28246518 )
2017
8
Core curriculum illustration: pediatric viral parotitis. ( 28593330 )
2017
9
Sialendoscopic Approach in Management of Juvenile Recurrent Parotitis. ( 29238673 )
2017
10
Development of acute parotitis after non-invasive ventilation. ( 28840025 )
2017
11
Sialoendoscopy combined with an internal stent and postoperative massage as a comprehensive treatment of delayed I(131)-induced parotitis. ( 28697989 )
2017
12
An unusual case of acute parotitis in a young adult. ( 28742741 )
2017
13
A case of neuromyelitis optica spectrum disorder (NMOSD) with SjAPgren's syndrome manifested only brain involvement by preceding parotitis. ( 28132975 )
2017
14
Chymotrypsin with sialendoscopy-assisted surgery for the treatment of chronic obstructive parotitis. ( 28279602 )
2017
15
Facial and limb angioedema with parotitis and Kikuchi-like necrotizing lymphadenitis preceding neuropsychiatric systemic lupus erythematosus in a young African American male. ( 28849689 )
2017
16
Viral etiology of sporadic cases of parotitis among children in Korea during 2013-2014. ( 28876460 )
2017
17
Parotitis as an Initial Symptom of Kawasaki Disease. ( 28593063 )
2017
18
Role of sialendoscopy in juvenile recurrent parotitis (JRP). ( 28669808 )
2017
19
Ultrasound elastography in diagnosis and follow-up for patients with chronic recurrent parotitis. ( 28885206 )
2017
20
Role of the Accessory Parotid Gland in the Etiology of Parotitis: Statistical Analysis of Sialographic Features. ( 26913509 )
2016
21
Melioidosis parotitis in children. ( 27980534 )
2016
22
Acute Parotitis as a Complication of Noninvasive Ventilation. ( 26928643 )
2016
23
Eosinophilic sialodochitis: redefinition of 'allergic parotitis' and 'sialodochitis fibrinosa'. ( 27748012 )
2016
24
Function of the parotid gland in juvenile recurrent parotitis: a case series. ( 26852271 )
2016
25
Parotitis and Sialendoscopy of the Parotid Gland. ( 26912292 )
2016
26
Chronic parotitis with multiple calcifications: Clinical and sialendoscopic findings. ( 27861944 )
2016
27
Presentation of acute suppurative parotitis in a newborn with incessant crying. ( 27986789 )
2016
28
Diagnosing Juvenile Recurrent Parotitis. Case Reports. ( 26939156 )
2016
29
A case of a male presenting with fever, parotitis, epididymo-orchitis, and kidney injury. ( 27012169 )
2016
30
Complete genome sequence of mumps viruses isolated from patients with parotitis, pancreatitis and encephalitis in India. ( 26876221 )
2016
31
Neonatal Suppurative Parotitis: Two Cases. ( 27351362 )
2016
32
Sialendoscopic treatment of recurrent juvenile parotitis: A South African case series. ( 27499410 )
2016
33
Concomitant Suppurative Parotitis and Condylar Osteomyelitis. ( 27717819 )
2016
34
Pediatric suppurative parotitis caused by Burkholderia pseudomallei. ( 27843446 )
2016
35
Botulinum Toxin for the Management of SjAPgren Syndrome-Associated Recurrent Parotitis. ( 27400144 )
2016
36
Bilateral parotitis in a patient under continuous positive airway pressure treatment. ( 27793244 )
2016
37
Decreased salivary matrix metalloproteinase-8 reflecting a defensive potential in juvenile parotitis. ( 26746616 )
2016
38
Streptococcus pneumoniae bacteraemia due to parotitis in a patient with systemic sclerosis and secondary SjAPgren's syndrome. ( 28348790 )
2016
39
Sialendoscopy-assisted treatment for chronic obstructive parotitis related to Sjogren syndrome. ( 28049607 )
2016
40
Tuberculous Lymphadenitis and Parotitis. ( 28084205 )
2016
41
Transient Parotitis After Oesophagogastroduodenoscopy: A Rare Complication. ( 26674606 )
2015
42
Acute suppurative parotitis in a 33-day-old patient. ( 25825340 )
2015
43
Onabotulinum toxin injection for parotid fistula treatment in a case of recurrent parotitis complicated with abscess formation. ( 25819498 )
2015
44
Bilateral acute neonatal suppurative parotitis: A rare finding in neonatal age. ( 25758001 )
2015
45
Group B streptococcal neonatal parotitis. ( 26063107 )
2015
46
Diffuse Nodular Lung Infiltrates in a Well Appearing Three-Year-Old Boy With Recurrent Sinopulmonary Infections and Parotitis. ( 26407362 )
2015
47
Evaluation and management of juvenile recurrent parotitis in children from northern Greece. ( 27688702 )
2015
48
Idiopathic Chronic Parotitis: Imaging Findings and Sialendoscopic Response. ( 26376430 )
2015
49
Eosinophilia and parotitis occurring early in clozapine treatment. ( 26373547 )
2015
50
Treatment of juvenile recurrent parotitis of childhood: an analysis of effectiveness. ( 25474272 )
2015

Variations for Parotitis

Expression for Parotitis

Search GEO for disease gene expression data for Parotitis.

Pathways for Parotitis

GO Terms for Parotitis

Cellular components related to Parotitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.55 ALB LTF MMP2 MMP9 SPINK1
2 extracellular space GO:0005615 9.02 ALB LTF MMP2 MMP9 SPINK1
3 tertiary granule lumen GO:1904724 8.96 LTF MMP9

Biological processes related to Parotitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen catabolic process GO:0030574 9.37 MMP2 MMP9
2 embryo implantation GO:0007566 9.32 MMP2 MMP9
3 retina homeostasis GO:0001895 9.26 ALB LTF
4 endodermal cell differentiation GO:0035987 9.16 MMP2 MMP9
5 cellular protein metabolic process GO:0044267 9.13 ALB LTF MMP2
6 positive regulation of vascular smooth muscle cell proliferation GO:1904707 8.62 MMP2 MMP9

Molecular functions related to Parotitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.8 LTF MMP2 MMP9

Sources for Parotitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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