MCID: PRT026
MIFTS: 45

Parotitis malady

Summaries for Parotitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Parotitis is an inflammation of one or both parotid glands, the major salivary glands located on either... more...

MalaCards: Parotitis, also known as parotitis nos, is related to sjogren's syndrome and thyroiditis. An important gene associated with Parotitis is SPINK1 (serine peptidase inhibitor, Kazal type 1). The compounds glutamate and alpha tocopherol have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lymph node and brain, and related mouse phenotypes are immune system and homeostasis/metabolism.

Aliases & Classifications for Parotitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 57SNOMED-CT, 35MeSH, 61UMLS
See all sources

Aliases & Descriptions:

parotitis 8 10 45
parotitis nos 8


External Ids:

Disease Ontology8 DOID:10301
MeSH35 D010309

Related Diseases for Parotitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Parotitis:



Diseases related to parotitis

Clinical Features for Parotitis

Drugs & Therapeutics for Parotitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Parotitis

Drug clinical trials:

Search ClinicalTrials for Parotitis

Search NIH Clinical Center for Parotitis

Search CenterWatch for Parotitis

Genetic Tests for Parotitis

Anatomical Context for Parotitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Parotitis:

33
Whole blood, Lymph node, Brain, Lung, Thyroid, Salivary gland, Breast, Myeloid, B lymphoblasts, B cells

Animal Models for Parotitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Parotitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.5CRP, LTF, CD79A, MMP2, MMP9, GGT1
2MP:00053766.7SPINK1, H6PD, G6PD, CRP, AKAP5, LTF

Publications for Parotitis

Sources:
51PubMed
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Articles related to Parotitis:

(show top 50)    (show all 496)
idTitleAuthorsYear
1
Parotitis as the presenting symptom of Wegener's granulomatosis: case report and meta-analysis. (23662387)
2013
2
Syphilitic parotitis. (21874818)
2011
3
Interventional sialendoscopy for treatment of juvenile recurrent parotitis. (22121310)
2011
4
Acute neonatal suppurative parotitis: a case report and review of the literature. (21621441)
2011
5
Elderly male with cheek swelling. Acute suppurative parotitis. (21183088)
2011
6
MRI and MR sialography of juvenile recurrent parotitis. (20467735)
2010
7
Juvenile recurrent parotitis: clinical, sialographic and ultrasonographic features. (17263859)
2007
8
Parotitis associated with a parainfluenza virus type 3 infection during aplasia after unrelated allogeneic stem cell transplantation. (16966297)
2006
9
Infantile recurrent parotitis: follow up study of five cases and literature review. (16612516)
2005
10
Asparaginase-induced acute parotitis: an uncommon and self-limiting complication. (12116090)
2002
11
Juvenile recurrent parotitis. (11255322)
2001
12
Acute pancreatitis and parotitis induced by methimazole in a patient with Graves' disease. (10594530)
1999
13
The possible significance of cytomegaloviral parotitis in infant and early childhood deaths. (9431318)
1997
14
Salmonella parotitis with abscess formation in a patient with human immunodeficiency virus infection. (9142815)
1997
15
Epstein-Barr virus associated parotitis. (9145372)
1997
16
Chronic suppurative parotitis: a proposed classification. (9206105)
1996
17
Clozapine-induced parotitis: an immunological cause? (8633706)
1996
18
Pneumococcal parotitis in a human immunodeficiency virus-infected child. (8745029)
1995
19
Management decisions in parotitis. (7743774)
1995
20
Tuberculosis as the cause of diffuse parotitis. (7661432)
1995
21
Serum autoantibodies in recurrent parotitis in children. (7552419)
1995
22
Parotitis in diarrhea-associated hemolytic uremic syndrome. (8451109)
1993
23
Recurrent parotitis. (1303637)
1992
24
Diffuse tuberculous parotitis. (1487671)
1992
25
Histopathologic findings in a case of recurrent parotitis in adulthood. (1447618)
1992
26
Aerobic and anaerobic microbiology of acute suppurative parotitis. (1992268)
1991
27
The surgical management of chronic parotitis. (2243516)
1990
28
Salivary scintigraphy with vitamin C stimulation: an aid in differentiating unilateral parotitis from Warthin's tumor. (2166667)
1990
29
Nifedipine-induced parotitis: a hypersensitivity reaction. (3354462)
1988
30
The swollen neck. Cervical lymphadenitis, parotitis, thyroiditis, and infected cysts. (3074109)
1988
31
The pathogenesis of chronic recurrent parotitis in infants: a study of 93 cases including an analysis of the vascular and glandular changes before and after parasympathectomy. (2970903)
1988
32
Acute suppurative parotitis in outpatients: microbiologic and posttreatment sialographic findings. (3468465)
1987
33
Comparative study on the neurovirulence of different vaccine strains of parotitis virus in monkeys. (2864823)
1985
34
Long-term follow-up of the effect of tympanic neurectomy on sialadenosis and recurrent parotitis. (4082982)
1985
35
The surgical treatment of chronic parotitis. (7175352)
1982
36
Recurrent parotitis during childhood. (7357780)
1980
37
chronic recurrent parotitis aetiopathogenesis. (291683)
1979
38
Ultrastructural observations on the parotitis autoimmunica in the NZB/NZW hybrid mice. (636877)
1978
39
Nosocomial parotitis. (983689)
1976
40
Experimental allergic sialoadenitis. 3. Acute parotitis induced by instillation of antiserum to rat plasma into the glandular duct of rats. (4629430)
1972
41
Tympanic neurectomy in chronic parotitis. (5114957)
1971
42
MENINGOENCEPHALOMYELITIS WITH EPIDEMIC PAROTITIS. CLINICOPATHOLOGIC REPORT. (14200655)
1964
43
Acute bacterial parotitis. (13952246)
1963
44
Incidence of viral parotitis in the domestic dog. (14427509)
1959
45
Effect of cortisone in orchitis of epidemic parotitis (mumps). (13366674)
1956
46
Recurrent bacterial parotitis. (14368479)
1955
47
Herpes zoster with a varicelliform eruption and parotitis in chronic leukemia. (14794487)
1951
48
Mumps with parotitis, meningoencephalitis and orchitis; report of case. (14801562)
1950
49
Epidemic parotitis complicated by acute suppurative appendicitis; report of a case. (14794364)
1950
50
Suppurative parotitis in an infant. (18904691)
1948

Genetic Variations for Parotitis

Expression for genes affiliated with Parotitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Parotitis

Search GEO for disease gene expression data for Parotitis.

Pathways for genes affiliated with Parotitis

Compounds for genes affiliated with Parotitis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Parotitis according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1glutamate4510.6AKAP5
2alpha tocopherol4510.6G6PD
3norepinephrine45 11 2412.5LTF
4neotetrazolium4510.3H6PD, G6PD
5aspartate4510.2LTF, G6PD
6o-ethylhydroxylamine4510.2G6PD, H6PD
7no-dimethylhydroxylamine4510.1G6PD, H6PD
8galactose-6-phosphate4510.1CRP, G6PD
9cyclophosphamide45 50 1112.1G6PD, CRP
10cgs-27023a4510.0MMP2, MMP9
11flavanol4510.0MMP9, MMP2
12gamma globulin459.9GGT1, CRP
13col 3459.9MMP9, MMP2
14glutaraldehyde459.9G6PD, CD79A, H6PD
15methyl selenol459.9MMP2, MMP9
16mannitol45 1110.8GGT1, CRP
17lactulose459.8CD79A, LTF, CRP
18pmma459.7CRP, CD79A, LTF
19sulfasalazine45 29 50 1112.7G6PD, CRP, CD79A
20succinate459.6MMP9, LTF, G6PD, H6PD
21malate459.6MMP9, H6PD, G6PD
22beta-cryptoxanthin459.5CRP, GGT1
23polyethylene glycol459.5G6PD, CD79A, CRP, H6PD
248-isoprostane459.5CRP, MMP2, MMP9
25alpha lipoic acid459.4GGT1, G6PD, MMP9
26doxycycline45 1110.4MMP2, CD79A, LTF, MMP9
27iron45 2410.4GGT1, LTF, H6PD, PGRMC1
28malondialdehyde459.3H6PD, G6PD, CRP, GGT1
29ivig459.3MMP2, CD79A, CRP, MMP9
30silymarin459.3MMP2, MMP9, GGT1
31methacholine45 1110.3CD79A, LTF, CRP
32citrate459.1G6PD, LTF, CD79A, CRP, MMP2
33ribavirin45 50 1111.0GGT1, MMP9, MMP2, LTF, G6PD
34vitamin b12459.0CRP, CD79A, LTF, GGT1, G6PD
35hyaluronic acid45 249.9GGT1, MMP2, LTF, CD79A, MMP9
36pioglitazone45 50 29 1111.9MMP9, G6PD, CRP, GGT1, MMP2
37vitamin a45 11 2410.8GGT1, MMP9, MMP2, LTF, CRP
38folate458.8MMP2, CD79A, CRP, G6PD, H6PD, MMP9
39methotrexate45 50 1110.8CD79A, MMP2, MMP9, GGT1, CRP
40glutamine458.7CRP, PML, LTF, GGT1, H6PD, G6PD
41aspirin45 50 29 2411.7CD79A, G6PD, CRP, MMP2
42azathioprine45 50 2 1111.6CD79A, GGT1, MMP2, LTF, CRP, G6PD
43h2o2458.4GGT1, MMP2, CD79A, LTF, PML, H6PD
44ascorbic acid45 249.3G6PD, MMP2, GGT1, H6PD, CD79A, LTF
45cysteine458.3H6PD, MMP2, LTF, GGT1, MMP9, CD79A
46lactate458.2MMP2, H6PD, G6PD, CRP, MMP9, GGT1
47n acetylcysteine458.2MMP2, CD79A, CRP, G6PD, GGT1, MMP9
48alanine458.1GGT1, MMP9, MMP2, CD79A, LTF, CRP
49testosterone45 60 11 2411.0MMP2, MMP9, CD79A, GGT1, PGRMC1, H6PD
50creatinine457.7MMP2, H6PD, G6PD, CRP, LTF, CD79A

GO Terms for genes affiliated with Parotitis

Sources:
16Gene Ontology
See all sources

Biological processes related to Parotitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pentose-phosphate shuntGO:0060989.9G6PD, H6PD

Molecular functions related to Parotitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glucose-6-phosphate dehydrogenase activityGO:0043459.6G6PD, H6PD
2protein bindingGO:0055156.5G6PD, CRP, AKAP5, TRIM28, LTF, PGRMC1

Products for genes affiliated with Parotitis

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Sources for Parotitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet