MCID: PRT026
MIFTS: 50

Parotitis malady

Oral diseases category
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Summaries for Parotitis

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Wikipedia:65 Parotitis is an inflammation of one or both parotid glands, the major salivary glands located on either... more...

MalaCards based summary: Parotitis, also known as parotitis nos, is related to lymphadenitis and pharyngitis. An important gene associated with Parotitis is SPINK1 (serine peptidase inhibitor, Kazal type 1), and among its related pathways are Pentose Phosphate Pathway and amb2 Integrin signaling. The compounds neotetrazolium and 6-Phosphonoglucono-D-lactone have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, thyroid and eye, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Parotitis

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Parotitis, Aliases & Descriptions:

Name: Parotitis 8 10 44 62
 
Parotitis Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Oral diseases


External Ids:

Disease Ontology8 DOID:10301
MeSH34 D010309

Related Diseases for Parotitis

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Diseases related to Parotitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 165)
idRelated DiseaseScoreTop Affiliating Genes
1lymphadenitis30.9CD79A
2pharyngitis30.6HSF4
3pancreatitis30.3CRP, SPINK1, H6PD, LTF
4otitis media30.2CD79A, LTF
5meningitis30.2MMP9, CD79A, CRP
6pneumonia30.2CD79A, HSF4, CRP
7kawasaki disease30.1CRP, MMP9
8ulcerative colitis30.0LTF, CRP
9systemic lupus erythematosus30.0CD79A, LTF, CRP
10diarrhea29.9LTF, CD79A, CRP
11tuberculosis29.9CRP, H6PD, CD79A
12ovarian cancer29.5SPINK1, MMP2, MMP9
13arthritis29.4LTF, MMP9, MMP2, CRP
14rheumatoid arthritis29.0CD79A, LTF, CRP, MMP9, MMP2
15mumps10.6
16trigeminal neuralgia10.5PGRMC1
17urethritis10.5CD79A
18cryptosporidiosis10.5CD79A
19aortic aneurysm10.5CRP
20lactose intolerance10.4LTF
21keratoconjunctivitis sicca10.4LTF
22blepharitis10.4LTF
23bacteriuria10.4CRP
24polyarteritis nodosa10.4LTF
25orchitis10.3
26glucosephosphate dehydrogenase deficiency10.3H6PD, G6PD
27influenza10.3
28autoimmune hemolytic anemia10.3G6PD, CD79A
29arthropathy10.3CRP
30malaria10.3G6PD, H6PD
31prostatitis10.3LTF, CD79A
32pyelonephritis10.3CD79A, CRP
33exanthem10.2CRP, CD79A
34shigellosis10.2LTF, CD79A
35sjogren's syndrome10.2
36wegener's granulomatosis10.2
37meningoencephalitis10.2
38facial paralysis10.2
39synovitis10.2CRP
40dental caries10.2LTF, CD79A
41iron deficiency anemia10.2G6PD, LTF
42candidiasis10.2CD79A, LTF
43iron metabolism disease10.2G6PD, CRP
44ankylosing spondylitis10.2CD79A, CRP
45leukemia10.2
46hemolytic anemia10.2G6PD, H6PD
47chorioamnionitis10.2CRP, LTF
48leukopenia10.2CD79A, CRP
49tonsillitis10.1HSF4, CRP, CD79A
50bronchitis10.1CD79A, CRP, HSF4

Graphical network of the top 20 diseases related to Parotitis:



Diseases related to parotitis

Symptoms for Parotitis

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Drugs & Therapeutics for Parotitis

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Drug clinical trials:

Search ClinicalTrials for Parotitis

Search NIH Clinical Center for Parotitis

Genetic Tests for Parotitis

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Anatomical Context for Parotitis

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MalaCards organs/tissues related to Parotitis:

32
Salivary gland, Thyroid, Eye, Bone, Lymph node, Brain, Lung, Breast, Myeloid

Animal Models for Parotitis or affiliated genes

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MGI Mouse Phenotypes related to Parotitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.3LTF, CD79A, CRP, MMP2, MMP9, SPINK1
2MP:00053977.0SPINK1, G6PD, MMP9, MMP2, CD79A, LTF
3MP:00053766.3LTF, SPINK1, G6PD, MMP9, MMP2, H6PD

Publications for Parotitis

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Articles related to Parotitis:

(show top 50)    (show all 507)
idTitleAuthorsYear
1
Juvenile recurrent parotitis in children: diagnosis and treatment using sialography. (25001449)
2014
2
Incessant cry--rare presentation of neonatal parotitis. (25252534)
2014
3
Acute transient parotitis in a child with primitive neuroectodermal tumor after a standard dose etoposide. (25006307)
2014
4
Transient parotitis after upper gastrointestinal endoscopy. (24338172)
2013
5
Sialendoscopy in juvenile recurrent parotitis: a review of the literature. (24376291)
2013
6
Acute neonatal parotitis caused by streptococcus pyogenes: a case report. (20164068)
2010
7
Transient parotitis after conscious sedation for endoscopy. (19319777)
2009
8
Community-acquired methicillin-resistant Staphylococcus aureus: an emerging cause of acute bacterial parotitis. (19139712)
2009
9
A life-threatening complication of acute parotitis. (17822812)
2008
10
Differentiating acute suppurative parotitis from acute exacerbation of a chronic parotitis: case reports. (18718411)
2008
11
Association between the occurrence of matrix metalloproteinases 2 and 9 in parotid saliva with the degree of parotid gland damage in juvenile recurrent parotitis. (18567510)
2008
12
Juvenile recurrent parotitis: clinical, sialographic and ultrasonographic features. (17263859)
2007
13
Bilateral suppurative parotitis in a newborn. (16624200)
2006
14
Parotitis due to ritodrine tocolytic treatment for preterm labor. (15806068)
2005
15
Extra-cranial metastasis of glioblastoma multiforme presenting as acute parotitis. (16455543)
2005
16
Asparaginase-induced acute parotitis: an uncommon and self-limiting complication. (12116090)
2002
17
Tuberculous parotitis. (12379196)
2002
18
Recurrent HIV parotitis. (11418740)
2001
19
Tympanic neurectomy and chronic parotitis. (11200598)
2000
20
Prophylactic antibiotics in recurrent parotitis in a patient with Sjogren's syndrome. (10357124)
1999
21
Sonographic analysis of recurrent parotitis in children: a comparative study with sialographic findings. (9830657)
1998
22
The possible significance of cytomegaloviral parotitis in infant and early childhood deaths. (9431318)
1997
23
Chronic suppurative parotitis: a proposed classification. (9206105)
1996
24
Recurrent parotitis. (8503688)
1993
25
Neonatal suppurative parotitis: a vanishing disease? (8131800)
1993
26
Recurrent parotitis in childhood. (8432079)
1993
27
Recurrent parotitis in childhood. (1563203)
1992
28
Parotitis in a three-year-old. (1878333)
1991
29
The surgical management of chronic parotitis. (2243516)
1990
30
Nosocomial gram-negative parotitis. (3079657)
1986
31
Computed tomography and sialography of chronic pyogenic parotitis. (6509287)
1984
32
Occlusion of Stenon's duct by prolamine: a possible treatment of chronic parotitis? Preliminary experience from animal experiments. (7070791)
1982
33
Infectious parotitis in SjAPgren's syndrome: a case report and review of the literature. (313447)
1979
34
Mumps pancreatitis without parotitis. (4692679)
1973
35
Parotitis, parotid abscess and facial palsy. (5058482)
1972
36
Primary suppurative parotitis. (5124870)
1971
37
Recurrent parotitis in children. (5357583)
1969
38
A case of suppurative parotitis. (5909099)
1966
39
PAROTITIS AND FACIAL PARALYSIS IN MID-LINE GRANULOMA. (14256342)
1965
40
POSTOPERATIVE PAROTITIS-PARAPAROTID SPACE INFECTION. REPORT OF A CASE. (14063805)
1964
41
Parotitis in weanling mice produced by Coxsackie B-1 (Conn.-5) virus. (14001101)
1962
42
Suppurative parotitis. (13689544)
1961
43
Postoperative parotitis: a complication in a fracture of the maxilla. (13780077)
1961
44
Chronic parotitis; with illustrative case report. (13553307)
1958
45
Chronic sialectatic parotitis in the light of pathological studies on parotidectomy material. (13260589)
1955
46
Recurrent parotitis in children. (13058436)
1953
47
Herpes zoster with a varicelliform eruption and parotitis in chronic leukemia. (14794487)
1951
48
Suppurative parotitis. (14777386)
1950
49
Mumps meningoencephalitis with and without parotitis. (18147966)
1949
50
Laryngeal edema in epidemic parotitis. (18913528)
1948

Variations for Parotitis

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Expression for genes affiliated with Parotitis

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Expression patterns in normal tissues for genes affiliated with Parotitis

Search GEO for disease gene expression data for Parotitis.

Pathways for genes affiliated with Parotitis

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Pathways related to Parotitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
pentose phosphate pathway (non-oxidative branch)37
pentose phosphate pathway37
PRPP biosynthesis37
9.6H6PD, G6PD
29.0MMP9, MMP2
3
Show member pathways
9.0MMP2, MMP9
49.0MMP2, MMP9
59.0MMP2, MMP9
69.0MMP2, MMP9
79.0MMP2, MMP9
89.0MMP9, MMP2

Compounds for genes affiliated with Parotitis

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Compounds related to Parotitis according to GeneCards/GeneDecks:

(show top 50)    (show all 142)
idCompoundScoreTop Affiliating Genes
1neotetrazolium4410.0H6PD, G6PD
26-Phosphonoglucono-D-lactone2410.0G6PD, H6PD
3o-ethylhydroxylamine449.9G6PD, H6PD
4galactose-6-phosphate449.9CRP, G6PD
5no-dimethylhydroxylamine449.8G6PD, H6PD
6glutaraldehyde449.6G6PD, H6PD, CD79A
7sulfasalazine28 44 50 1112.5CRP, G6PD, CD79A
8lactulose449.4LTF, CRP, CD79A
9pmma449.4LTF, CRP, CD79A
10cgs-27023a449.3MMP2, MMP9
11flavanol449.3MMP2, MMP9
12methacholine44 50 1111.3LTF, CD79A, CRP
13col 3449.2MMP9, MMP2
14methyl selenol449.2MMP2, MMP9
15polyethylene glycol449.1H6PD, G6PD, CD79A, CRP
16malate449.1MMP9, G6PD, H6PD
17neopterin449.0LTF, CD79A, CRP
18malondialdehyde449.0H6PD, CRP, G6PD
19vitamin b12449.0CRP, CD79A, LTF, G6PD
20lactose44 119.9LTF, MMP9, G6PD
218-isoprostane448.9MMP9, MMP2, CRP
22aspirin44 50 28 2411.8CD79A, G6PD, MMP2, CRP
23erythromycin44 2 50 1111.8MMP9, LTF, MMP2
24succinate448.7H6PD, LTF, MMP9, G6PD
25cyclophosphamide44 50 1110.5MMP9, G6PD, CRP, LTF
26ivig448.5MMP2, CRP, CD79A, MMP9
27doxycycline44 119.5MMP9, MMP2, CD79A, LTF
28hyaluronic acid44 249.5CD79A, LTF, MMP2, MMP9
29epinephrine44 24 1110.5G6PD, CD79A, MMP2, MMP9
30ribavirin44 50 1110.5G6PD, MMP9, LTF, MMP2
31chloramphenicol44 2 50 1111.5LTF, CRP, MMP9, G6PD
32pioglitazone28 44 50 1111.5G6PD, MMP9, MMP2, CRP
33h2o2448.4G6PD, MMP2, H6PD, LTF, CD79A
34methotrexate50 44 1110.4MMP2, MMP9, CRP, CD79A
35azathioprine44 2 50 1111.4CRP, MMP2, G6PD, CD79A, LTF
36citrate448.4LTF, CRP, G6PD, MMP2, CD79A
37vitamin a44 24 1110.4MMP9, MMP2, CRP, LTF
38fibrinogen448.3MMP9, CD79A, LTF, CRP
39ascorbic acid44 249.0LTF, H6PD, G6PD, CD79A, CRP, MMP2
40norepinephrine44 24 1110.0CRP, LTF, MMP9, CD79A, MMP2
41aspartate447.9LTF, MMP9, MMP2, G6PD, CRP
42vegf447.8MMP2, LTF, CD79A, MMP9, CRP
43folate447.7CRP, H6PD, MMP2, MMP9, CD79A, G6PD
44lactate447.7G6PD, CRP, H6PD, MMP2, MMP9, CD79A
45estrogen447.7LTF, PGRMC1, CD79A, G6PD, MMP9, MMP2
46alanine447.6MMP2, CRP, CD79A, LTF, MMP9
47n acetylcysteine447.6LTF, G6PD, CRP, CD79A, MMP2, MMP9
48glutamate447.4LTF, CD79A, H6PD, MMP2, MMP9
49testosterone44 61 24 1110.4CD79A, CRP, H6PD, MMP9, PGRMC1, G6PD
50creatinine446.9LTF, G6PD, MMP9, MMP2, H6PD, CRP

GO Terms for genes affiliated with Parotitis

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Cellular components related to Parotitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.0LTF, CRP, MMP2, MMP9
2extracellular regionGO:0055767.4LTF, CRP, MMP2, MMP9, SPINK1

Biological processes related to Parotitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pentose-phosphate shuntGO:0060989.3H6PD, G6PD
2embryo implantationGO:0075669.0MMP2, MMP9

Molecular functions related to Parotitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glucose-6-phosphate dehydrogenase activityGO:0043459.5H6PD, G6PD
2NADP bindingGO:0506619.3H6PD, G6PD
3protein bindingGO:0055156.9MMP2, CRP, PGRMC1, G6PD, SPINK1, LTF

Products for genes affiliated with Parotitis

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Sources for Parotitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet