Aliases & Classifications for Parotitis

Aliases & Descriptions for Parotitis:

Name: Parotitis 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10301
ICD10 33 K11.2
MeSH 42 D010309
NCIt 47 C114281
UMLS 69 C0030583

Summaries for Parotitis

Disease Ontology : 12 A parotid disease characterized by the inflammation of one or both parotid glands.

MalaCards based summary : Parotitis is related to viral meningitis and mumps. An important gene associated with Parotitis is SPINK1 (Serine Peptidase Inhibitor, Kazal Type 1), and among its related pathways/superpathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Bladder cancer. The drugs Isoniazid and Pyrazinamide have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, thyroid and lung, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 71 Parotitis is an inflammation of one or both parotid glands, the major salivary glands located on either... more...

Related Diseases for Parotitis

Diseases related to Parotitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
id Related Disease Score Top Affiliating Genes
1 viral meningitis 27.8 CD79A G6PD H6PD LTF MMP2 MMP9
2 mumps 11.2
3 toxic optic neuropathy 10.2 CD79A MMP9
4 cellulitis 10.2 CD79A MMP9
5 diversion colitis 10.2 CD79A MMP9
6 facio skeletal genital syndrome rippberger type 10.2 MMP2 MMP9
7 acute tricyclic antidepressant poisoning 10.2 MMP2 MMP9
8 isthmus cancer 10.2 CD79A MMP9
9 kleptomania 10.2 MMP2 MMP9
10 leukoencephalopathy palmoplantar keratoderma 10.2 MMP2 MMP9
11 thymus adenocarcinoma 10.2 MMP2 MMP9
12 spinal meninges cancer 10.2 MMP2 MMP9
13 neonatal hypoxic and ischemic brain injury 10.1 MMP2 MMP9
14 senile atrophy of choroid 10.1 MMP2 MMP9
15 tinea profunda 10.1 MMP2 MMP9
16 lymphocytic colitis 10.1 MMP2 MMP9
17 adenocarcinoma in situ 10.1 MMP2 MMP9
18 appendix carcinoid tumor 10.1 MMP2 MMP9
19 corneal staphyloma 10.1 MMP2 MMP9
20 linear porokeratosis 10.1 MMP2 MMP9
21 schwannomatosis 10.1 MMP2 MMP9
22 striated muscle rhabdoid tumor 10.1 MMP2 MMP9
23 cerebral beriberi 10.1 G6PD MMP9
24 retinal artery occlusion 10.1 MMP2 MMP9
25 omsk hemorrhagic fever 10.1 CD79A MMP9
26 bulbomembranous urethral cancer 10.1 MMP2 MMP9
27 adult neuronal ceroid lipofuscinosis 10.1 MMP2 MMP9
28 maxillary neoplasm 10.1 MMP2 MMP9
29 breast papillary carcinoma 10.1 MMP2 MMP9
30 adenoid squamous cell carcinoma 10.1 MMP2 MMP9
31 onychocytic matricoma 10.1 MMP2 MMP9
32 trichomalacia 10.1 MMP2 MMP9
33 retinal drusen 10.1 MMP2 MMP9
34 severe acute respiratory syndrome 10.1 MMP2 MMP9
35 laryngostenosis 10.1 MMP2 MMP9
36 nodular cutaneous amyloidosis 10.1 MMP2 MMP9
37 endometriosis of uterus 10.1 G6PD H6PD
38 breast abscess 10.1 MMP2 MMP9
39 subacute monocytic leukemia 10.1 G6PD H6PD
40 infertility due to extratesticular cause 10.0 CD79A LTF
41 chronic polyneuropathy 10.0 MMP2 MMP9
42 adenoiditis 10.0 CD79A LTF
43 maxillary sinus cholesteatoma 10.0 MMP2 MMP9
44 traumatic brain injury 10.0 MMP2 MMP9
45 perinatal necrotizing enterocolitis 10.0 CD79A LTF
46 lower lip cancer 10.0 MMP2 MMP9
47 mikulicz disease 10.0 CD79A LTF
48 histiocytosis 10.0 CD79A MMP2 MMP9
49 spastic entropion 10.0 CD79A LTF
50 vascular dementia 10.0 MMP2 MMP9

Graphical network of the top 20 diseases related to Parotitis:



Diseases related to Parotitis

Symptoms & Phenotypes for Parotitis

MGI Mouse Phenotypes related to Parotitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.63 SPINK1 CD79A G6PD LTF MMP2 MMP9
2 homeostasis/metabolism MP:0005376 9.5 CD79A G6PD H6PD LTF MMP2 MMP9
3 neoplasm MP:0002006 8.92 CD79A LTF MMP2 MMP9

Drugs & Therapeutics for Parotitis

Drugs for Parotitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 71)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isoniazid Approved Phase 4 54-85-3 3767
2
Pyrazinamide Approved Phase 4 98-96-4 1046
3
Rifampin Approved Phase 4 13292-46-1 5458213 5381226
4 Anti-Bacterial Agents Phase 4,Phase 1,Phase 2
5 Antibiotics, Antitubercular Phase 4,Phase 1,Phase 2
6 Anti-Infective Agents Phase 4,Phase 1,Phase 2
7 Antimetabolites Phase 4,Phase 1,Phase 2
8 Antitubercular Agents Phase 4
9 Cytochrome P-450 CYP3A Inducers Phase 4
10 Hypolipidemic Agents Phase 4
11 Lipid Regulating Agents Phase 4
12 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 1,Phase 2
13 Vaccines Phase 4,Phase 3,Phase 2,Phase 1
14 Antibodies Phase 4,Phase 1,Phase 2
15 Immunoglobulins Phase 4,Phase 1,Phase 2
16 Heptavalent Pneumococcal Conjugate Vaccine Phase 3
17
Busulfan Approved, Investigational Phase 1, Phase 2 55-98-1 2478
18
Cyclosporine Approved, Investigational, Vet_approved Phase 1, Phase 2 79217-60-0, 59865-13-3 5284373 6435893
19
Fludarabine Approved Phase 1, Phase 2 21679-14-1, 75607-67-9 30751
20
Lenograstim Approved Phase 1, Phase 2 135968-09-1
21
Methotrexate Approved Phase 1, Phase 2 1959-05-2, 59-05-2 126941
22
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
23
Mycophenolate mofetil Approved, Investigational Phase 1, Phase 2 128794-94-5 5281078
24
Mycophenolic acid Approved Phase 1, Phase 2 24280-93-1 446541
25
Phenytoin Approved, Vet_approved Phase 1, Phase 2 57-41-0 1775
26
Vidarabine Approved Phase 1, Phase 2 24356-66-9 32326 21704
27
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
28
leucovorin Approved, Nutraceutical Phase 1, Phase 2 58-05-9 54575, 6560146 143
29 Adjuvants, Immunologic Phase 1, Phase 2
30 Alkylating Agents Phase 1, Phase 2
31 Anticonvulsants Phase 1, Phase 2
32 Antifungal Agents Phase 1, Phase 2
33 Antimetabolites, Antineoplastic Phase 1, Phase 2
34 Antineoplastic Agents, Alkylating Phase 1, Phase 2
35 Antirheumatic Agents Phase 1, Phase 2
36 Antiviral Agents Phase 1, Phase 2
37 Calcineurin Inhibitors Phase 1, Phase 2
38 Calcium, Dietary Phase 1, Phase 2
39 Dermatologic Agents Phase 1, Phase 2
40 Disinfectants Phase 1, Phase 2
41 Diuretics, Potassium Sparing Phase 1, Phase 2
42 Folic Acid Antagonists Phase 1, Phase 2
43 Hormones Phase 1, Phase 2
44 Immunosuppressive Agents Phase 1, Phase 2
45 Interleukin-2 Phase 1, Phase 2
46 Interleukin-4 Phase 1, Phase 2
47 Krestin Phase 1, Phase 2
48 Mitogens Phase 1, Phase 2
49 Sodium Channel Blockers Phase 1, Phase 2
50 Vitamin B Complex Phase 1, Phase 2

Interventional clinical trials:

(show all 31)
id Name Status NCT ID Phase
1 A Randomized Trial of Three Regimens to Prevent Tuberculosis in HIV-Infected Patients With Anergy Completed NCT00402610 Phase 4
2 Comparative Study of the Immunogenicity of MMR (Measles, Mumps and Rubella) Single Dose and Multidose Presentations Completed NCT01777529 Phase 4
3 Measles, Mumps, and Rubella (MMR) Immunity in College Students Completed NCT00962819 Phase 4
4 Immunogenicity and Safety of Hepatitis A Vaccine Given at the Same Time of Measles, Mumps, Rubella Combined Vaccine Completed NCT00313950 Phase 4
5 Immunogenicity and Safety of Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases Completed NCT00126997 Phase 4
6 Immunogenicity and Safety of Japanese Encephalitis Vaccine When Given With Measles-Mumps-Rubella Vaccine Recruiting NCT02880865 Phase 4
7 Safety and Immunogenicity Study of GlaxoSmithKline (GSK) Biologicals' Measles, Mumps and Rubella (MMR) Vaccine (209762) Compared to Merck & Co., Inc.'s MMR Vaccine in Healthy Children 12 to 15 Months of Age Completed NCT02184572 Phase 3
8 Immunogenicity and Safety of GSK Biologicals' Combined Measles-mumps-rubella Vaccine in Volunteers, Seven Years of Age and Older Completed NCT02058563 Phase 3
9 Study of Immunogenicity, Reactogenicity and Safety of the Combined Measles, Mumps and Rubella Vaccine Produced by Bio-Manguinhos/Fiocruz in Children 12-15 Months of Age, Followed by Tetraviral Vaccine in Children 15-18 Months. Completed NCT01991899 Phase 3
10 Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Combined Measles-mumps-rubella (MMR) Vaccine in Children in Their Second Year of Life Completed NCT01681992 Phase 3
11 Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Combined Measles-mumps-rubella (MMR) Vaccine in Subjects Four to Six Years of Age Completed NCT01621802 Phase 3
12 Safety, Tolerability, and Immunogenicity of Measles, Mumps, Rubella, and Varicella (MMRV) Vaccine Made With an Alternative Manufacturing Process (AMP)(V221-027) Completed NCT01536405 Phase 3
13 Study of Japanese Encephalitis Chimeric Virus Vaccine Given With Measles-Mumps-Rubella Vaccine in Taiwanese Toddlers Completed NCT01188343 Phase 3
14 Comparison of GSK Measles-mumps-rubella-varicella (MMRV) Vaccine Versus PriorixTM Completed NCT00969436 Phase 3
15 Immunogenicity & Safety Study of GSK Biologicals' Combined Measles-mumps-rubella-varicella Vaccine 208136 Completed NCT00751348 Phase 3
16 Long-term Follow-up on Immunogenicity & Safety of Measles-Mumps-Rubella-Varicella (MMRV) Combined Vaccine Completed NCT00406211 Phase 3
17 Immunogenicity and Safety of a Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases Completed NCT00127023 Phase 3
18 Immunogenicity and Safety of a Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases Completed NCT00127010 Phase 3
19 Study to Evaluate Frozen Versus Refrigerated MMRV (Combined Measles, Mumps, Rubella, and Varicella) Investigational Vaccine (V221-016) Completed NCT00092430 Phase 3
20 A Study of An Approved Vaccine at Mumps Expiry Potency in Healthy Children 12 to 18 Months of Age (V205C-007)(COMPLETED) Completed NCT00092391 Phase 3
21 Safety and Immunogenicity Study of Live Attenuated Mumps Vaccines in Healthy Infants Active, not recruiting NCT02692599 Phase 3
22 Busulfan, Fludarabine, and Total-Body Irradiation in Treating Patients Who Are Undergoing a Donor Stem Cell Transplant for Hematologic Cancer Completed NCT00245037 Phase 1, Phase 2
23 Immunogenicity, Safety of Measles-mumps-rubella-varicella Vaccine (MeMuRu-OKA) Compared to Priorix™ Given With Varilrix™ Completed NCT00353288 Phase 2
24 Immunogenicity, Safety of Measles-mumps-rubella-varicella Vaccine (MeMuRu-OKA) Compared to Priorix™ Given With Varilrix™ Completed NCT00352898 Phase 2
25 Phase II of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants Not yet recruiting NCT03133923 Phase 2
26 A Phase I, Safety Study of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Chinese Children Completed NCT01712906 Phase 1
27 Serological Study in Children 12 to 23 Months Vaccinated With MMR (Measles, Mumps and Rubella) Completed NCT01874457
28 Making Decisions About the Measles-Mumps-Rubella Vaccine Completed NCT01369394
29 SPI-directed Analgesia for Vitreoretinal Surgeries Recruiting NCT02973581
30 Gender and Opioid Consumption Not yet recruiting NCT03006627
31 Safety Study of Measles-Mumps-Rubella-Varicella (MMRV) Vaccine, Priorix-Tetra™ in Children Living in the Philippines Withdrawn NCT01738841

Search NIH Clinical Center for Parotitis

Cochrane evidence based reviews: parotitis

Genetic Tests for Parotitis

Anatomical Context for Parotitis

MalaCards organs/tissues related to Parotitis:

39
Salivary Gland, Thyroid, Lung, Bone, Myeloid, Kidney, Breast

Publications for Parotitis

Articles related to Parotitis:

(show top 50) (show all 551)
id Title Authors Year
1
Decreased salivary matrix metalloproteinase-8 reflecting a defensive potential in juvenile parotitis. ( 26746616 )
2016
2
Function of the parotid gland in juvenile recurrent parotitis: a case series. ( 26852271 )
2016
3
Tuberculous Lymphadenitis and Parotitis. ( 28084205 )
2016
4
Acute Parotitis as a Complication of Noninvasive Ventilation. ( 26928643 )
2016
5
Concomitant Suppurative Parotitis and Condylar Osteomyelitis. ( 27717819 )
2016
6
Parotitis and Sialendoscopy of the Parotid Gland. ( 26912292 )
2016
7
Botulinum Toxin for the Management of SjAPgren Syndrome-Associated Recurrent Parotitis. ( 27400144 )
2016
8
Diagnosing Juvenile Recurrent Parotitis. Case Reports. ( 26939156 )
2016
9
A case of a male presenting with fever, parotitis, epididymo-orchitis, and kidney injury. ( 27012169 )
2016
10
Pediatric suppurative parotitis caused by Burkholderia pseudomallei. ( 27843446 )
2016
11
Melioidosis parotitis in children. ( 27980534 )
2016
12
Bilateral parotitis in a patient under continuous positive airway pressure treatment. ( 27793244 )
2016
13
Neonatal Suppurative Parotitis: Two Cases. ( 27351362 )
2016
14
Role of the Accessory Parotid Gland in the Etiology of Parotitis: Statistical Analysis of Sialographic Features. ( 26913509 )
2016
15
Chronic parotitis with multiple calcifications: Clinical and sialendoscopic findings. ( 27861944 )
2016
16
Eosinophilic sialodochitis: redefinition of 'allergic parotitis' and 'sialodochitis fibrinosa'. ( 27748012 )
2016
17
Complete genome sequence of mumps viruses isolated from patients with parotitis, pancreatitis and encephalitis in India. ( 26876221 )
2016
18
Presentation of acute suppurative parotitis in a newborn with incessant crying. ( 27986789 )
2016
19
Sialendoscopic treatment of recurrent juvenile parotitis: A South African case series. ( 27499410 )
2016
20
Sialendoscopy-assisted treatment for chronic obstructive parotitis related to Sjogren syndrome. ( 28049607 )
2016
21
Evaluation and management of juvenile recurrent parotitis in children from northern Greece. ( 27688702 )
2015
22
Treatment of juvenile recurrent parotitis of childhood: an analysis of effectiveness. ( 25474272 )
2015
23
Acute suppurative parotitis in a 33-day-old patient. ( 25825340 )
2015
24
Idiopathic Chronic Parotitis: Imaging Findings and Sialendoscopic Response. ( 26376430 )
2015
25
Fistulectomy of the parotid fistula secondary to suppurative parotitis: a case report. ( 25709371 )
2015
26
Diffuse Nodular Lung Infiltrates in a Well Appearing Three-Year-Old Boy With Recurrent Sinopulmonary Infections and Parotitis. ( 26407362 )
2015
27
Uncovering a Unique Cause of Parotitis in an Adolescent. ( 26324663 )
2015
28
Eosinophilia and parotitis occurring early in clozapine treatment. ( 26373547 )
2015
29
Bilateral acute neonatal suppurative parotitis: A rare finding in neonatal age. ( 25758001 )
2015
30
Onabotulinum toxin injection for parotid fistula treatment in a case of recurrent parotitis complicated with abscess formation. ( 25819498 )
2015
31
Transient Parotitis After Oesophagogastroduodenoscopy: A Rare Complication. ( 26674606 )
2015
32
Group B streptococcal neonatal parotitis. ( 26063107 )
2015
33
Acute suppurative parotitis caused by Streptococcus pneumoniae in an HIV-infected man. ( 25733094 )
2015
34
Beware of parotitis induced by iodine-containing contrast media. ( 24625945 )
2014
35
Suppurative parotitis in a girl: a case report from ahvaz, iran. ( 25485063 )
2014
36
Juvenile recurrent parotitis: A retrospective comparison of sialendoscopy versus conservative therapy. ( 23818258 )
2014
37
Potassium Dehydroandrographolide Succinate Injection for the treatment of child epidemic parotitis: A systematic review and meta-analysis. ( 25491538 )
2014
38
Recurrent parotitis of childhood or juvenile recurrent parotitis--a review and report of two cases. ( 24640481 )
2014
39
Incessant cry--rare presentation of neonatal parotitis. ( 25252534 )
2014
40
Atypical presentation of systemic lupus erythematosus: parotitis and secondary Sjogren's syndrome. Case report. ( 25076705 )
2014
41
Juvenile recurrent parotitis. ( 24623953 )
2014
42
Acute bilateral parotitis occurring during venlafaxine titration in an adolescent female with major depression. ( 24443175 )
2014
43
Recurrent juvenile parotitis: a rare bilateral presentation. ( 25225189 )
2014
44
Sialendoscopy for the management of juvenile recurrent parotitis: A systematic review and meta-analysis. ( 25393103 )
2014
45
Unveiling the hidden eagle: acute parotitis-induced eagle syndrome. ( 24696832 )
2014
46
Suppurative parotitis and submandibular sialadenitis. ( 24741539 )
2014
47
Sialendoscopy for the diagnosis and treatment of juvenile recurrent parotitis. ( 24468237 )
2014
48
Treatment of chronic recurrent juvenile parotitis using sialendoscopy. ( 24597494 )
2014
49
Neonatal suppurative parotitis: a case report. ( 25755871 )
2014
50
Acute bacterial parotitis in the frail elderly subject: a harbinger of death? ( 24613469 )
2014

Variations for Parotitis

Expression for Parotitis

Search GEO for disease gene expression data for Parotitis.

Pathways for Parotitis

GO Terms for Parotitis

Cellular components related to Parotitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 tertiary granule lumen GO:1904724 8.62 LTF MMP9

Biological processes related to Parotitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix disassembly GO:0022617 9.43 MMP2 MMP9
2 glucose metabolic process GO:0006006 9.4 G6PD H6PD
3 collagen catabolic process GO:0030574 9.37 MMP2 MMP9
4 embryo implantation GO:0007566 9.32 MMP2 MMP9
5 endodermal cell differentiation GO:0035987 9.26 MMP2 MMP9
6 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.16 MMP2 MMP9
7 pentose-phosphate shunt GO:0006098 8.96 G6PD H6PD
8 NADP metabolic process GO:0006739 8.62 G6PD H6PD

Molecular functions related to Parotitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.33 LTF MMP2 MMP9
2 NADP binding GO:0050661 8.96 G6PD H6PD
3 glucose-6-phosphate dehydrogenase activity GO:0004345 8.62 G6PD H6PD

Sources for Parotitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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