MCID: PRT026
MIFTS: 50

Parotitis malady

Oral diseases category

Summaries for Parotitis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Parotitis is an inflammation of one or both parotid glands, the major salivary glands located on either... more...

MalaCards: Parotitis, also known as parotitis nos, is related to lymphadenitis and pancreatitis. An important gene associated with Parotitis is SPINK1 (serine peptidase inhibitor, Kazal type 1), and among its related pathways are Pentose Phosphate Pathway and amb2 Integrin signaling. The compounds neotetrazolium and 6-Phosphonoglucono-D-lactone have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, thyroid and brain, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Parotitis

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 36MeSH, 59SNOMED-CT, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Oral diseases


Aliases & Descriptions:

parotitis 9 11 46
parotitis nos 9


External Ids:

Disease Ontology9 DOID:10301
MeSH36 D010309

Related Diseases for Parotitis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Parotitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1lymphadenitis30.4CD79A
2pancreatitis30.3CRP, SPINK1, H6PD, LTF
3meningitis30.3MMP9, CD79A, CRP
4pneumonia30.1CD79A, HSF4, CRP
5kawasaki disease30.1CRP, MMP9
6pharyngitis30.0HSF4
7arthritis29.9LTF, MMP9, MMP2, CRP
8ulcerative colitis29.9LTF, CRP
9diarrhea29.8LTF, CD79A, CRP
10tuberculosis29.8CRP, H6PD, CD79A
11systemic lupus erythematosus29.8CD79A, LTF, CRP
12ovarian cancer29.7SPINK1, MMP2, MMP9
13rheumatoid arthritis29.6CD79A, LTF, CRP, MMP9, MMP2
14mumps10.6
15orchitis10.3
16influenza10.3
17meningoencephalitis10.2
18facial paralysis10.2
19sjogren's syndrome10.2
20wegener's granulomatosis10.2
21leukemia10.2
22herpes zoster10.1
23cervicitis10.1
24thyroiditis10.1
25trigeminal neuralgia10.1PGRMC1
26urethritis10.1CD79A
27cryptosporidiosis10.1CD79A
28aortic aneurysm10.1CRP
29lactose intolerance10.1LTF
30keratoconjunctivitis sicca10.1LTF
31blepharitis10.1LTF
32bacteriuria10.1CRP
33polyarteritis nodosa10.1LTF
34glucosephosphate dehydrogenase deficiency10.1H6PD, G6PD
35autoimmune hemolytic anemia10.1G6PD, CD79A
36otitis media10.1CD79A, LTF
37arthropathy10.1CRP
38malaria10.1G6PD, H6PD
39prostatitis10.1LTF, CD79A
40pyelonephritis10.1CD79A, CRP
41exanthem10.1CRP, CD79A
42shigellosis10.1LTF, CD79A
43synovitis10.1CRP
44dental caries10.1LTF, CD79A
45iron deficiency anemia10.1G6PD, LTF
46candidiasis10.0CD79A, LTF
47iron metabolism disease10.0G6PD, CRP
48ankylosing spondylitis10.0CD79A, CRP
49hemolytic anemia10.0G6PD, H6PD
50chorioamnionitis10.0CRP, LTF

Graphical network of the top 20 diseases related to Parotitis:



Diseases related to parotitis

Symptoms for Parotitis

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Drugs & Therapeutics for Parotitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Parotitis

Search CenterWatch for Parotitis

Genetic Tests for Parotitis

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Anatomical Context for Parotitis

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34MalaCards
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MalaCards organs/tissues related to Parotitis:

34
Salivary gland, Thyroid, Brain, Bone, Lung, Lymph node, Eye, Breast, Myeloid

Animal Models for Parotitis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Parotitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.3LTF, CD79A, CRP, MMP2, MMP9, SPINK1
2MP:00053977.0SPINK1, G6PD, MMP9, MMP2, CD79A, LTF
3MP:00053766.3LTF, SPINK1, G6PD, MMP9, MMP2, H6PD

Publications for Parotitis

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Sources:
53PubMed
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Articles related to Parotitis:

(show top 50)    (show all 493)
idTitleAuthorsYear
1
Transient parotitis after upper gastrointestinal endoscopy. (24338172)
2013
2
Sialendoscopy in juvenile recurrent parotitis: a review of the literature. (24376291)
2013
3
Acute neonatal parotitis caused by streptococcus pyogenes: a case report. (20164068)
2010
4
Transient parotitis after conscious sedation for endoscopy. (19319777)
2009
5
Community-acquired methicillin-resistant Staphylococcus aureus: an emerging cause of acute bacterial parotitis. (19139712)
2009
6
A life-threatening complication of acute parotitis. (17822812)
2008
7
Differentiating acute suppurative parotitis from acute exacerbation of a chronic parotitis: case reports. (18718411)
2008
8
Association between the occurrence of matrix metalloproteinases 2 and 9 in parotid saliva with the degree of parotid gland damage in juvenile recurrent parotitis. (18567510)
2008
9
Juvenile recurrent parotitis: clinical, sialographic and ultrasonographic features. (17263859)
2007
10
Bilateral suppurative parotitis in a newborn. (16624200)
2006
11
Recurrent parotitis in a seven year-old boy. (16208064)
2005
12
Parotitis due to ritodrine tocolytic treatment for preterm labor. (15806068)
2005
13
Extra-cranial metastasis of glioblastoma multiforme presenting as acute parotitis. (16455543)
2005
14
Asparaginase-induced acute parotitis: an uncommon and self-limiting complication. (12116090)
2002
15
Tuberculous parotitis. (12379196)
2002
16
Recurrent HIV parotitis. (11418740)
2001
17
Tympanic neurectomy and chronic parotitis. (11200598)
2000
18
Acute suppurative parotitis: uncommon presentation in a premature infant. (10693102)
2000
19
Prophylactic antibiotics in recurrent parotitis in a patient with Sjogren's syndrome. (10357124)
1999
20
Sonographic analysis of recurrent parotitis in children: a comparative study with sialographic findings. (9830657)
1998
21
The possible significance of cytomegaloviral parotitis in infant and early childhood deaths. (9431318)
1997
22
Chronic suppurative parotitis: a proposed classification. (9206105)
1996
23
Pneumococcal parotitis in a human immunodeficiency virus-infected child. (8745029)
1995
24
Recurrent parotitis. (8503688)
1993
25
Neonatal suppurative parotitis: a vanishing disease? (8131800)
1993
26
Recurrent parotitis in childhood. (8432079)
1993
27
Recurrent parotitis in childhood. (1563203)
1992
28
Parotitis in a three-year-old. (1878333)
1991
29
The surgical management of chronic parotitis. (2243516)
1990
30
Nosocomial gram-negative parotitis. (3079657)
1986
31
Computed tomography and sialography of chronic pyogenic parotitis. (6509287)
1984
32
Occlusion of Stenon's duct by prolamine: a possible treatment of chronic parotitis? Preliminary experience from animal experiments. (7070791)
1982
33
Mumps pancreatitis without parotitis. (4692679)
1973
34
Parotitis, parotid abscess and facial palsy. (5058482)
1972
35
Primary suppurative parotitis. (5124870)
1971
36
Subtotal and total parotidectomy for chronic bacterial parotitis. (4394980)
1970
37
Recurrent parotitis in children. (5357583)
1969
38
A case of suppurative parotitis. (5909099)
1966
39
PAROTITIS AND FACIAL PARALYSIS IN MID-LINE GRANULOMA. (14256342)
1965
40
POSTOPERATIVE PAROTITIS-PARAPAROTID SPACE INFECTION. REPORT OF A CASE. (14063805)
1964
41
Parotitis in weanling mice produced by Coxsackie B-1 (Conn.-5) virus. (14001101)
1962
42
Suppurative parotitis. (13689544)
1961
43
Postoperative parotitis: a complication in a fracture of the maxilla. (13780077)
1961
44
Chronic parotitis; with illustrative case report. (13553307)
1958
45
Chronic sialectatic parotitis in the light of pathological studies on parotidectomy material. (13260589)
1955
46
Recurrent parotitis in children. (13058436)
1953
47
Herpes zoster with a varicelliform eruption and parotitis in chronic leukemia. (14794487)
1951
48
Suppurative parotitis. (14777386)
1950
49
Mumps meningoencephalitis with and without parotitis. (18147966)
1949
50
Laryngeal edema in epidemic parotitis. (18913528)
1948

Variations for Parotitis

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Expression for genes affiliated with Parotitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Parotitis

Search GEO for disease gene expression data for Parotitis.

Pathways for genes affiliated with Parotitis

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 31KEGG, 54QIAGEN, 55R&D Systems
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Pathways related to Parotitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
pentose phosphate pathway (non-oxidative branch)39
pentose phosphate pathway39
PRPP biosynthesis39
9.6H6PD, G6PD
29.0MMP9, MMP2
3
Show member pathways
9.0MMP2, MMP9
49.0MMP2, MMP9
59.0MMP2, MMP9
69.0MMP2, MMP9
79.0MMP2, MMP9
89.0MMP9, MMP2

Compounds for genes affiliated with Parotitis

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Sources:
46Novoseek, 25HMDB, 30IUPHAR, 52PharmGKB, 12DrugBank, 3BitterDB, 62Tocris Bioscience
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Compounds related to Parotitis according to GeneCards/GeneDecks:

(show top 50)    (show all 142)
idCompoundScoreTop Affiliating Genes
1neotetrazolium4610.0H6PD, G6PD
26-Phosphonoglucono-D-lactone2510.0G6PD, H6PD
3o-ethylhydroxylamine469.9G6PD, H6PD
4galactose-6-phosphate469.9CRP, G6PD
5no-dimethylhydroxylamine469.8G6PD, H6PD
6glutaraldehyde469.6G6PD, H6PD, CD79A
7sulfasalazine30 46 52 1212.5CRP, G6PD, CD79A
8lactulose469.4LTF, CRP, CD79A
9pmma469.4LTF, CRP, CD79A
10cgs-27023a469.3MMP2, MMP9
11flavanol469.3MMP2, MMP9
12methacholine46 52 1211.3LTF, CD79A, CRP
13col 3469.2MMP9, MMP2
14methyl selenol469.2MMP2, MMP9
15polyethylene glycol469.1H6PD, G6PD, CD79A, CRP
16malate469.1MMP9, G6PD, H6PD
17neopterin469.0LTF, CD79A, CRP
18malondialdehyde469.0H6PD, CRP, G6PD
19vitamin b12469.0CRP, CD79A, LTF, G6PD
20lactose46 129.9LTF, MMP9, G6PD
218-isoprostane468.9MMP9, MMP2, CRP
22aspirin46 52 30 2511.8CD79A, G6PD, MMP2, CRP
23erythromycin46 3 52 1211.8MMP9, LTF, MMP2
24succinate468.7H6PD, LTF, MMP9, G6PD
25cyclophosphamide46 52 1210.5MMP9, G6PD, CRP, LTF
26ivig468.5MMP2, CRP, CD79A, MMP9
27doxycycline46 129.5MMP9, MMP2, CD79A, LTF
28hyaluronic acid46 259.5CD79A, LTF, MMP2, MMP9
29epinephrine46 25 1210.5G6PD, CD79A, MMP2, MMP9
30ribavirin46 52 1210.5G6PD, MMP9, LTF, MMP2
31chloramphenicol46 3 52 1211.5LTF, CRP, MMP9, G6PD
32pioglitazone30 46 52 1211.5G6PD, MMP9, MMP2, CRP
33h2o2468.4G6PD, MMP2, H6PD, LTF, CD79A
34methotrexate52 46 1210.4MMP2, MMP9, CRP, CD79A
35azathioprine46 3 52 1211.4CRP, MMP2, G6PD, CD79A, LTF
36citrate468.4LTF, CRP, G6PD, MMP2, CD79A
37vitamin a46 25 1210.4MMP9, MMP2, CRP, LTF
38fibrinogen468.3MMP9, CD79A, LTF, CRP
39ascorbic acid46 259.0LTF, H6PD, G6PD, CD79A, CRP, MMP2
40norepinephrine46 25 1210.0CRP, LTF, MMP9, CD79A, MMP2
41aspartate467.9LTF, MMP9, MMP2, G6PD, CRP
42vegf467.8MMP2, LTF, CD79A, MMP9, CRP
43folate467.7CRP, H6PD, MMP2, MMP9, CD79A, G6PD
44lactate467.7G6PD, CRP, H6PD, MMP2, MMP9, CD79A
45estrogen467.7LTF, PGRMC1, CD79A, G6PD, MMP9, MMP2
46alanine467.6MMP2, CRP, CD79A, LTF, MMP9
47n acetylcysteine467.6LTF, G6PD, CRP, CD79A, MMP2, MMP9
48glutamate467.4LTF, CD79A, H6PD, MMP2, MMP9
49testosterone46 62 25 1210.4CD79A, CRP, H6PD, MMP9, PGRMC1, G6PD
50creatinine466.9LTF, G6PD, MMP9, MMP2, H6PD, CRP

GO Terms for genes affiliated with Parotitis

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17Gene Ontology
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Cellular components related to Parotitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.0LTF, CRP, MMP2, MMP9
2extracellular regionGO:0055767.4LTF, CRP, MMP2, MMP9, SPINK1

Biological processes related to Parotitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pentose-phosphate shuntGO:0060989.3H6PD, G6PD
2embryo implantationGO:0075669.0MMP2, MMP9

Molecular functions related to Parotitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glucose-6-phosphate dehydrogenase activityGO:0043459.5H6PD, G6PD
2NADP bindingGO:0506619.3H6PD, G6PD
3protein bindingGO:0055156.9G6PD, PGRMC1, MMP9, MMP2, CRP, LTF

Products for genes affiliated with Parotitis

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Sources for Parotitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet