MCID: PRT026
MIFTS: 46

Parotitis malady

Summaries for Parotitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Parotitis is an inflammation of one or both parotid glands, the major salivary glands located on either... more...

MalaCards: Parotitis, also known as parotitis nos, is related to pancreatitis and meningitis. An important gene associated with Parotitis is SPINK1 (serine peptidase inhibitor, Kazal type 1). The compounds glutamate and alpha tocopherol have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, thyroid and eye, and related mouse phenotypes are immune system and homeostasis/metabolism.

Aliases & Classifications for Parotitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 56SNOMED-CT, 34MeSH, 60UMLS
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Aliases & Descriptions:

parotitis 8 10 44
parotitis nos 8


External Ids:

Disease Ontology8 DOID:10301
MeSH34 D010309

Related Diseases for Parotitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Parotitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 181)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis30.3LTF, H6PD, GGT1, SPINK1, CRP
2meningitis30.2MMP9, CD79A, CRP
3leukemia30.2CD79A, PML
4sjogren's syndrome30.2LTF, SSB, CD79A
5thyroiditis30.1CD79A
6lymphadenitis30.1CD79A
7acute pancreatitis30.1CRP, SPINK1
8kawasaki disease29.9CRP, MMP9
9pneumonia29.9CRP, HSF4, CD79A
10arthritis29.9LTF, CRP, MMP2, MMP9
11pharyngitis29.7HSF4
12purpura29.7CD79A
13lupus erythematosus29.7CD79A
14hepatitis29.7GGT1
15appendicitis29.7CRP
16hyperuricemia29.7GGT1
17asthma29.7MMP9, CD79A
18tuberculosis29.7CRP, CD79A, H6PD
19diarrhea29.7CRP, LTF, CD79A
20glioblastoma multiforme29.7MMP9, MMP2
21systemic lupus erythematosus29.7LTF, SSB, CD79A, CRP
22ovarian cancer29.7MMP2, SPINK1, MMP9, GGT1
23breast cancer29.7PGRMC1, MMP2, PML, MMP9, G6PD
24rheumatoid arthritis29.7CRP, LTF, CD79A, MMP2, MMP9
25mumps10.6
26orchitis10.3
27influenza10.2
28meningoencephalitis10.2
29facial paralysis10.2
30wegener's granulomatosis10.1
31herpes zoster10.1
32acute leukemia10.1
33cervicitis10.1
34rubella10.0
35chronic tympanitis10.0
36lymphocytic choriomeningitis10.0
37infectious mononucleosis10.0
38lymphoblastic leukemia10.0
39myocarditis10.0
40sarcoma10.0
41polycythemia vera10.0G6PD
42polycythemia10.0G6PD
43gingivitis10.0LTF
44schistosomiasis10.0CD79A
45psoriasis10.0LTF
46sinusitis10.0CD79A
47antiphospholipid syndrome10.0CD79A
48nephritis10.0CD79A
49glomerulonephritis10.0CD79A
50peritonitis10.0CRP

Graphical network of the top 20 diseases related to Parotitis:



Diseases related to parotitis

Clinical Features for Parotitis

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Drugs & Therapeutics for Parotitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Parotitis

Drug clinical trials:

Search ClinicalTrials for Parotitis

Search NIH Clinical Center for Parotitis

Search CenterWatch for Parotitis

Genetic Tests for Parotitis

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Anatomical Context for Parotitis

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32MalaCards
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MalaCards organs/tissues related to Parotitis:

32
Salivary gland, Thyroid, Eye, Bone, Lymph node, Brain, Lung, Breast, Myeloid

Animal Models for Parotitis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Parotitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.5PML, CRP, LTF, CD79A, MMP2, MMP9
2MP:00053766.7H6PD, G6PD, CRP, AKAP5, LTF, CD79A

Publications for Parotitis

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50PubMed
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Articles related to Parotitis:

(show top 50)    (show all 497)
idTitleAuthorsYear
1
Transient parotitis after upper gastrointestinal endoscopy. (24338172)
2013
2
Effects of huangqi and bear bile on recurrent parotitis in children: a new clinical approach. (23463769)
2013
3
Obstructive parotitis from extraorally introduced foreign body in the Stensen duct. (23945518)
2013
4
Chronic obstructive parotitis due to strictures of Stenson's duct--our treatment experience with sialoendoscopy. (20006159)
2010
5
HIV parotitis. (20329412)
2009
6
Bilateral acute parotitis following insertion of a Sengstaken-Blakemore tube. (19637131)
2009
7
Parotitis during oral double-balloon enteroscopy: an unexpected but benign finding. (19174796)
2009
8
An unusual case of acute unilateral parotitis following abdominal surgery. Report of a case and review of the literature. (20131541)
2009
9
Acute parotitis after double-balloon endoscopy. (18514652)
2008
10
Occurrence of suppurative parotitis in elderly people remains a bad omen. (18380680)
2008
11
Juvenile recurrent parotitis: sialendoscopic approach. (18645120)
2008
12
Unspecific parotitis can be the first indication of a developing Wegener's granulomatosis. (17653747)
2008
13
Acute bilateral parotitis caused by Mycobacterium scrofulaceum: immune reconstitution disease in a patient with AIDS. (16326858)
2005
14
Tuberculous parotitis. (12379196)
2002
15
Tuberculous parotitis: a forgotten entity. (12075235)
2002
16
Recurrent HIV parotitis. (11418740)
2001
17
A false-positive I-131 whole-body scan in chronic parotitis: a case report. (11353302)
2001
18
Delayed puberty and parotitis: an unusual presentation of HIV 15 years after infection in an untreated 17-year-old Malawian. (11676069)
2001
19
Images in clinical medicine. Suppurative parotitis. (11547720)
2001
20
Sonographic analysis of recurrent parotitis in children: a comparative study with sialographic findings. (9830657)
1998
21
A case of Lyme disease with parotitis. (9873181)
1998
22
Staphylococcal parotitis in AIDS: a case report. (8914919)
1996
23
Parotitis due to Torulopsis glabrata. (8589177)
1995
24
Chronic obstructive parotitis. Report of ninety-two cases. (1574304)
1992
25
Recurrent parotitis and sialectasis in childhood. Clinical, radiologic, immunologic, bacteriologic, and histologic study. (2064262)
1991
26
Acute suppurative parotitis. (2387955)
1990
27
Streptococcus pneumoniae acute suppurative parotitis in a patient with SjAPgren's syndrome. (2192076)
1990
28
Quantitative bacteriology of a case of acute parotitis. (2682427)
1989
29
Parotitis in Reiter's syndrome. (2453485)
1988
30
Natural history of patients with recurrent parotitis and punctate sialectasis. (3756441)
1986
31
Gaffkya anaerobia infection and recurrent parotitis. (3698456)
1986
32
New concepts in the treatment of chronic recurrent parotitis. (2416305)
1985
33
Acute suppurative parotitis secondary to a foreign body in Stensen's duct. (6358484)
1983
34
Hyperuricemia: a possible etiologic factor in chronic recurrent parotitis. (7132521)
1982
35
A study on the pathogenesis of recurrent parotitis in childhood. (118698)
1979
36
Hemorrhagic parotitis as a complication of carotid endarterectomy. (517876)
1979
37
Pica and parotitis. (863453)
1977
38
Acute parotitis associated with influenza type A: a report of twelve cases. (859547)
1977
39
Surgical treatment of chronic suppurative parotitis. A critical review. (926971)
1977
40
Letter: Wind parotitis. (4742231)
1973
41
Suppurative parotitis in children. (4195402)
1970
42
Acute parotitis associated with parainfluenza 3 virus infection. (4312194)
1970
43
Oxyphenbutazone-induced parotitis. (5789512)
1969
44
Acute suppurative parotitis. Twenty-eight cases at a county hospital. (14018707)
1963
45
Treatment of specific infections in the surgical patient. III. Parotitis and enterocolitis. (14005963)
1961
46
A new syndrome of parotitis with herpangina caused by the Coxsackie virus. (13437259)
1957
47
Surgical parotitis, a vanishing disease. (13256277)
1955
48
Gynaecological and obstetric acute secondary parotitis. (13188643)
1954
49
Suppurative parotitis. (14777386)
1950
50
Mumps meningoencephalitis with and without parotitis. (18147966)
1949

Genetic Variations for Parotitis

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Expression for genes affiliated with Parotitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Parotitis

Search GEO for disease gene expression data for Parotitis.

Pathways for genes affiliated with Parotitis

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Compounds for genes affiliated with Parotitis

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB, 59Tocris Bioscience
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Compounds related to Parotitis according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1glutamate4410.6AKAP5
2alpha tocopherol4410.6G6PD
3norepinephrine44 11 2412.5LTF
4neotetrazolium4410.3G6PD, H6PD
5aspartate4410.2LTF, G6PD
6o-ethylhydroxylamine4410.2H6PD, G6PD
7no-dimethylhydroxylamine4410.1H6PD, G6PD
8galactose-6-phosphate4410.1CRP, G6PD
9cyclophosphamide44 49 1112.0G6PD, CRP
10flavanol4410.0MMP9, MMP2
11cgs-27023a4410.0MMP9, MMP2
12methyl selenol449.9MMP9, MMP2
13gamma globulin449.9GGT1, CRP
14glutaraldehyde449.9G6PD, CD79A, H6PD
15col 3449.9MMP2, MMP9
16mannitol44 1110.8GGT1, CRP
17lactulose449.8LTF, CRP, CD79A
18pmma449.7LTF, CD79A, CRP
19sulfasalazine44 28 49 1112.7G6PD, CRP, CD79A
20succinate449.6H6PD, G6PD, MMP9, LTF
21beta-cryptoxanthin449.5GGT1, CRP
22polyethylene glycol449.5H6PD, CRP, CD79A, G6PD
238-isoprostane449.5MMP2, CRP, MMP9
24doxycycline44 1110.4MMP9, MMP2, CD79A, LTF
25alpha lipoic acid449.4GGT1, MMP9, G6PD
26erythromycin44 49 2 1112.4MMP2, LTF, MMP9
27iron44 2410.4GGT1, PGRMC1, LTF, H6PD
28malondialdehyde449.3GGT1, CRP, H6PD, G6PD
29silymarin449.3MMP9, GGT1, MMP2
30ivig449.3CRP, MMP9, CD79A, MMP2
31methacholine44 1110.3CD79A, LTF, CRP
32citrate449.1G6PD, CRP, LTF, MMP2, CD79A
33ribavirin44 49 1111.0G6PD, GGT1, LTF, MMP9, MMP2
34vitamin b12449.0GGT1, LTF, CD79A, CRP, G6PD
35hyaluronic acid44 249.9LTF, MMP2, MMP9, GGT1, CD79A
36pioglitazone44 49 28 1111.9CRP, MMP2, MMP9, GGT1, G6PD
37vitamin a44 11 2410.8MMP2, GGT1, CRP, LTF, MMP9
38folate448.8MMP2, CRP, CD79A, MMP9, G6PD, H6PD
39methotrexate44 49 1110.8CRP, CD79A, MMP2, MMP9, GGT1
40glutamine448.7LTF, CRP, G6PD, H6PD, GGT1, PML
41aspirin44 49 28 2411.7CD79A, MMP2, CRP, G6PD
42azathioprine44 49 2 1111.6LTF, CRP, G6PD, GGT1, CD79A, MMP2
43h2o2448.4GGT1, CD79A, LTF, G6PD, H6PD, PML
44ascorbic acid44 249.3GGT1, CD79A, LTF, CRP, G6PD, H6PD
45cysteine448.3GGT1, MMP9, MMP2, PML, H6PD, LTF
46lactate448.2MMP2, G6PD, MMP9, GGT1, CD79A, H6PD
47n acetylcysteine448.2MMP2, GGT1, MMP9, CD79A, LTF, CRP
48alanine448.1CRP, MMP9, MMP2, CD79A, LTF, GGT1
49testosterone44 59 11 2411.0MMP2, CD79A, MMP9, G6PD, H6PD, GGT1
50creatinine447.7LTF, H6PD, G6PD, CRP, MMP2, MMP9

GO Terms for genes affiliated with Parotitis

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16Gene Ontology
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Biological processes related to Parotitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pentose-phosphate shuntGO:0060989.9G6PD, H6PD

Molecular functions related to Parotitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glucose-6-phosphate dehydrogenase activityGO:0043459.6G6PD, H6PD
2protein bindingGO:0055156.5G6PD, CRP, AKAP5, TRIM28, LTF, PGRMC1

Products for genes affiliated with Parotitis

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Sources for Parotitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet