MCID: PRX035
MIFTS: 28

Paroxysmal Dyskinesia malady

Neuronal diseases category

Summaries for Paroxysmal Dyskinesia

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63Wikipedia, 32MalaCards
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Wikipedia:63 The paroxysmal dyskinesias (PD) are a group of movement disorders characterized by attacks of... more...

MalaCards: Paroxysmal Dyskinesia, also known as paroxysmal dystonic choreoathetosis, is related to generalized epilepsy and paroxysmal dyskinesia and migraine. An important gene associated with Paroxysmal Dyskinesia is KCNMA1 (potassium large conductance calcium-activated channel, subfamily M, alpha member 1). The compounds 4-aminopyridine and l-tryptophan have been mentioned in the context of this disorder.

Aliases & Classifications for Paroxysmal Dyskinesia

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48Orphanet, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

paroxysmal dyskinesia 48
paroxysmal dystonic choreoathetosis 48
paroxysmal choreoathetosis 48
dyskinesias, paroxysmal 60


External Ids:

MESH via Orphanet35 D002819
ICD10 via Orphanet26 G24.8
UMLS via Orphanet61 C0752210

Related Diseases for Paroxysmal Dyskinesia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Paroxysmal Dyskinesia:



Diseases related to paroxysmal dyskinesia

Clinical Features for Paroxysmal Dyskinesia

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Drugs & Therapeutics for Paroxysmal Dyskinesia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Paroxysmal Dyskinesia

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Anatomical Context for Paroxysmal Dyskinesia

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Animal Models for Paroxysmal Dyskinesia or affiliated genes

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Publications for Paroxysmal Dyskinesia

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Genetic Variations for Paroxysmal Dyskinesia

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Expression for genes affiliated with Paroxysmal Dyskinesia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Paroxysmal Dyskinesia

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Pathways for genes affiliated with Paroxysmal Dyskinesia

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Compounds for genes affiliated with Paroxysmal Dyskinesia

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Paroxysmal Dyskinesia according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
14-aminopyridine44 2810.7CNR1, KCNMA1
2l-tryptophan44 28 11 2412.7KMO, SLC16A2
3ns1619289.6KCNMA1, KCNT2, KCNT1
4ns004289.6KCNMA1, KCNT2, KCNT1
5cyppa59 2810.6KCNT1, KCNT2, KCNMA1
6tram 34599.6KCNT1, KCNT2, KCNMA1
7paxilline28 44 5911.6KCNMA1, KCNT2, KCNT1
8iberiotoxin44 59 2811.6KCNT1, KCNT2, KCNMA1
9charybdotoxin44 2810.6KCNMA1, KCNT2, KCNT1
10apamin44 59 2811.5KCNMA1, KCNT2, KCNT1
11glibenclamide44 28 49 5912.5SLC2A1, CNR1, KCNMA1
12gaba449.3SLC2A1, CNR1, KCNMA1
13tetraethylammonium44 28 1111.1KCNT1, KCNT2, KCNMA1, CNR1
14aspirin44 49 28 2412.0SLC2A1, CNR1, KCNMA1
15carbachol44 28 1110.8DYT10, CNR1, SLC2A1
16thapsigargin44 599.7KCNMA1, DYT10, CNR1, SLC2A1
17nmda44 289.7KCNMA1, DYT10, CNR1, KMO
18adenylate448.5SLC2A1, CNR1, DYT10, KCNMA1
19glutamate448.2SLC2A1, KMO, CNR1, DYT10, KCNMA1

GO Terms for genes affiliated with Paroxysmal Dyskinesia

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Sources:
16Gene Ontology
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Cellular components related to Paroxysmal Dyskinesia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated potassium channel complexGO:0080769.3KCNMA1, KCNT2, KCNT1

Biological processes related to Paroxysmal Dyskinesia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to osmotic stressGO:0069709.8SLC2A1, KCNMA1
2potassium ion transmembrane transportGO:0718059.0KCNMA1, KCNT2, KCNT1

Molecular functions related to Paroxysmal Dyskinesia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated potassium channel activityGO:0052499.3KCNMA1, KCNT2, KCNT1
2calcium-activated potassium channel activityGO:0152699.0KCNMA1, KCNT2, KCNT1

Products for genes affiliated with Paroxysmal Dyskinesia

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Sources for Paroxysmal Dyskinesia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet