MCID: PRS012
MIFTS: 40

Pars Planitis malady

Genetic diseases, Rare diseases, Eye diseases categories

Summaries for Pars Planitis

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NIH Rare Diseases:41 Pars planitis is a disease of the eye in which there is inflammation of the pars plana, a small area of tissue next to the iris that is responsible for making aqueous humor (the fluid in the eye that nourishes the lens and cornea).  pars planitis is often referred to as intermediate uveitis because the pars plana is a part of the uvea.  this condition most often affects young men and is generally not associated with any other disease or symptoms (idiopathic). however, there have been a few case reports of an association with crohn's disease, and some experts suggest a possible association with multiple sclerosis, sarcoidosis, cat scratch or lyme disease. last updated: 4/8/2012

MalaCards based summary: Pars Planitis, also known as familial pars planitis, is related to uveitis and hodgkin lymphoma. An important gene associated with Pars Planitis is CD27 (CD27 molecule), and among its related pathways are TNF Signaling and Immune response IFN alpha beta signaling pathway. The compounds lipoteichoic acid and gold sodium thiomalate have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and t cells.

Wikipedia:63 Intermediate uveitis is a form of uveitis localized to the vitreous and peripheral retina. Primary sites... more...

Aliases & Classifications for Pars Planitis

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Pars Planitis, Aliases & Descriptions:

Name: Pars Planitis 9 41 60
Familial Pars Planitis 41 60
Vitritis 41 60
Peripheral Retinal Inflammation 41
 
Infectious Posterior Uveitis 41
Uveitis, Intermediate 60
Intermediate Uveitis 41
Posterior Cyclitis 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology9 DOID:12731
NCIt38 C34903
MeSH33 D015868
ICD9CM27 363.21
ICD1025 H30.2

Related Diseases for Pars Planitis

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Diseases related to Pars Planitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis30.9HLA-A, HLA-B
2hodgkin lymphoma29.9IL1RN, HLA-A, HLA-B
3melanoma29.5CD27, HLA-DRB1, HLA-A, HLA-B
4intermediate uveitis10.6
5dengue shock syndrome10.4IL1RN
6cataract10.4
7iridocyclitis10.4
8retinal detachment10.4
9retinitis10.4
10retinoschisis10.3
11crohn's disease10.3
12corneal ectasia10.3
13macular holes10.3
14posterior uveitis10.3
15choroiditis10.3
16cone dystrophy10.3
17demyelinating disease10.3
18acute zonal occult outer retinopathy10.3
19retinal vasculitis10.2
20vasculitis10.2
21chorioretinitis10.2
22cytomegalovirus retinitis10.2
23endophthalmitis10.2
24spondyloarthropathy 110.2IL1RN, HLA-B
25polymyalgia rheumatica10.1HLA-DRB1, IL1RN
26follicular lymphoma10.1CD27, HLA-B
27dermatomyositis10.1IL1RN, HLA-B
28polymyositis10.1HLA-B, IL1RN
29plasmodium falciparum malaria10.1HLA-B, HLA-DRB1
30myositis10.1HLA-B, IL1RN
31juvenile rheumatoid arthritis10.1IL1RN, HLA-DRB1
32tetanus10.1CD27, HLA-B
33acne10.1
34alopecia10.1
35granuloma annulare10.1
36rubella10.1
37cat-scratch disease10.1
38acute disseminated encephalomyelitis10.1
39alopecia areata10.1
40eosinophilia10.1
41tuberculosis10.1
42human immunodeficiency virus infectious disease10.1CD27, HLA-A
43hypersensitivity syndrome, carbamazepine-induced10.1HLA-B, HLA-A
44primary biliary cirrhosis10.0HLA-DRB1, HLA-B
45behcet's disease10.0HLA-A, HLA-B
46vaccinia10.0HLA-A, HLA-B
47hemochromatosis10.0HLA-B, HLA-A
48uveal melanoma10.0HLA-B, HLA-A
49west nile virus10.0
50multiple myeloma10.0

Graphical network of the top 20 diseases related to Pars Planitis:



Diseases related to pars planitis

Symptoms for Pars Planitis

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Drugs & Therapeutics for Pars Planitis

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Drug clinical trials:

Search ClinicalTrials for Pars Planitis

Search NIH Clinical Center for Pars Planitis

Genetic Tests for Pars Planitis

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Anatomical Context for Pars Planitis

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MalaCards organs/tissues related to Pars Planitis:

31
Eye, Retina, T cells

Animal Models for Pars Planitis or affiliated genes

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Publications for Pars Planitis

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Articles related to Pars Planitis:

(show top 50)    (show all 90)
idTitleAuthorsYear
1
Rhegmatogenous retinal detachment due to a macular hole in a patient with pars planitis: a case report. (25565856)
2015
2
Treatment with immunosuppressive therapy in patients with pars planitis: experience of a reference centre in Mexico. (24985727)
2014
3
Four years old, one eye, pars planitis and cataract: surgical challenges give challenging surprises. (23626571)
2013
4
Association of epiretinal membranes with macular edema in pars planitis. (24332688)
2013
5
Effects of twice-daily topical difluprednate 0.05% emulsion in a child with pars planitis. (21034305)
2011
6
Acute zonal occult outer retinopathy (AZOOR) and pars planitis: a new association? (18369082)
2008
7
Pars planitis: a 20-year study of incidence, clinical features, and outcomes. (18724984)
2008
8
Pars planitis is associated with an increased frequency of effector-memory CD57+ T cells. (17475702)
2007
9
Pars planitis in children: epidemiologic, clinical, and therapeutic characteristics. (17913171)
2007
10
Pars planitis: a 20-year study of incidence, clinical features, and outcomes. (18036872)
2007
11
The enigma of pars planitis, revisited. (16564810)
2006
12
The appearance of pars planitis in multiple sclerosis. (16117323)
2005
13
Clinical symptoms and complications of pars planitis in childhood. (15849986)
2005
14
Phacoemulsification with intraocular lens implantation in cases of pars planitis. (15474816)
2004
15
Genetic polymorphism of HLA DR in a Scottish population of patients with pars planitis. (12841565)
2003
16
Pars planitis in the Mexican Mestizo population: ocular findings, treatment, and visual outcome. (12854027)
2003
17
An old crone finds a new home: Crohn's disease and pars planitis. (12789592)
2002
18
Vitrectomy for pars planitis complicated by vitreous hemorrhage: visual outcome and long-term follow-up. (11292422)
2001
19
Pars planitis: epidemiology, treatment, and association with multiple sclerosis. (11449325)
2001
20
Familial pars planitis and dominant optic atrophy. (9134550)
1997
21
Blood serum interleukin-1 receptor antagonist in pars planitis and ocular BehAset disease. (9152064)
1997
22
Coats'-like response in a patient with pars planitis. (8795387)
1996
23
Ultrasound biomicroscopy in pars planitis. (8623895)
1996
24
Pars planitis: epidemiology and clinical outcome in a large community hospital in Mexico City. (8586494)
1995
25
Pars planitis in a family. (7814201)
1994
26
Cataract extraction in patients with pars planitis. (8341504)
1993
27
Intraocular lens implantation versus no intraocular lens implantation in patients with chronic iridocyclitis and pars planitis. A randomized prospective study. (8341503)
1993
28
The association of HLA-B8, B51, DR2, and multiple sclerosis in pars planitis. (8341502)
1993
29
Intermediate uveitis: what is the significance of the pars plana exudate in 'pars planitis'? A summary. (1730374)
1992
30
Multiple sclerosis, sarcoidosis and other diseases in patients with pars planitis. (1309708)
1992
31
Treatment of pars planitis with cryotherapy. (1945296)
1991
32
Lens implant surgery in pars planitis. (2402411)
1990
33
Neovascularization of the disc in pars planitis. (1708516)
1990
34
Pars planitis in father and son. (2096359)
1990
35
Clinical and immunopathological studies of pars planitis in a family. (3257703)
1988
36
The enigma of pars planitis. (3591882)
1987
37
Pars planitis and autoimmune endotheliopathy. (3631195)
1987
38
The significance of the pars plana exudate in pars planitis. (3578463)
1987
39
Pars planitis and rod-cone dystrophy. (6333906)
1983
40
Pars planitis--a demyelinating disease? (7224943)
1981
41
Pars planitis. (6963826)
1981
42
Treatment of pars planitis. I. cryotherapy. (918841)
1977
43
Pars planitis. (269542)
1977
44
Treatment of pars planitis II. corticosteroids. (918842)
1977
45
Inflammation in the region of the vitreous base. Pars planitis. (1070846)
1976
46
Cytostatics in the treatment of chronic cyclitis ('pars-planitis'). (980401)
1976
47
Origin of macular edema caused by pars planitis]. (48223)
1975
48
Fibroglial proliferation in pars planitis. (1066857)
1975
49
Iridocyclitis with hemorrhagic pars planitis due to Microfilaria bancrofti. (4675032)
1972
50
The fine structure of the vitreous base of the human eye and pathogenesis of pars planitis. (5091131)
1971

Variations for Pars Planitis

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Expression for genes affiliated with Pars Planitis

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Search GEO for disease gene expression data for Pars Planitis.

Pathways for genes affiliated with Pars Planitis

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Pathways related to Pars Planitis according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.2CD27, HLA-A
2
Show member pathways
9.1HLA-B, HLA-A
3
Show member pathways
9.1HLA-A, HLA-B
49.1HLA-A, HLA-B
5
Show member pathways
TCR signaling in naive CD8+ T cells36
9.0HLA-DRB1, HLA-A
6
Show member pathways
Immune response IL 12 induced IFN gamma production58
9.0HLA-DRB1, HLA-A
7
Show member pathways
8.5HLA-B, HLA-A, HLA-DRB1
8
Show member pathways
8.5HLA-DRB1, HLA-A, HLA-B
98.5HLA-DRB1, HLA-A, HLA-B
108.5HLA-B, HLA-A, HLA-DRB1
118.5HLA-B, HLA-A, HLA-DRB1
12
Show member pathways
8.5HLA-DRB1, HLA-A, HLA-B
13
Show member pathways
8.5HLA-B, HLA-A, HLA-DRB1
148.5HLA-DRB1, HLA-A, HLA-B
15
Show member pathways
8.0IL1RN, HLA-DRB1, HLA-A, HLA-B

Compounds for genes affiliated with Pars Planitis

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Compounds related to Pars Planitis according to GeneCards Suite gene sharing:

(show all 22)
idCompoundScoreTop Affiliating Genes
1lipoteichoic acid439.8IL1RN, HLA-B
2gold sodium thiomalate439.7IL1RN, HLA-DRB1
3latex439.6IL1RN, HLA-B
4allergens439.6HLA-DRB1, IL1RN
5p003439.6IL1RN, HLA-B
6allopurinol43 49 1211.5HLA-A, HLA-B
7ursodeoxycholic acid43 24 1211.4HLA-A, HLA-B
8carbamazepine43 49 1211.4HLA-A, HLA-B
9dr-10439.4HLA-DRB1, HLA-A
10carbohydrates439.3HLA-B, IL1RN
11p002439.2IL1RN, HLA-A
12endotoxin439.1IL1RN, HLA-B
135-aza-2deoxycytidine439.1HLA-A, HLA-B
14cyclosporin a43 28 5910.9HLA-B, HLA-A, IL1RN
15adenylate438.9IL1RN, HLA-A, HLA-B
16atp43 289.8IL1RN, HLA-DRB1, HLA-B
17zinc43 249.8HLA-B, HLA-A, IL1RN
18oligonucleotide438.8HLA-DRB1, HLA-A, HLA-B
19arginine438.7HLA-DRB1, HLA-A, HLA-B
20alanine438.6HLA-A, HLA-DRB1, IL1RN
21calcium43 49 24 1211.4HLA-B, HLA-A, IL1RN, CD27
22tyrosine438.3HLA-B, HLA-A, HLA-DRB1, IL1RN

GO Terms for genes affiliated with Pars Planitis

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Cellular components related to Pars Planitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:00426129.2HLA-A, HLA-B
2early endosome membraneGO:00319019.1HLA-A, HLA-B
3phagocytic vesicle membraneGO:00306708.8HLA-A, HLA-B
4integral component of lumenal side of endoplasmic reticulum membraneGO:00715568.7HLA-DRB1, HLA-A, HLA-B
5ER to Golgi transport vesicle membraneGO:00125078.7HLA-B, HLA-A, HLA-DRB1
6Golgi membraneGO:00001398.4HLA-B, HLA-A, HLA-DRB1
7integral component of plasma membraneGO:00058878.1HLA-B, HLA-A, HLA-DRB1, CD27
8extracellular vesicular exosomeGO:00700628.0IL1RN, HLA-DRB1, HLA-A, HLA-B

Biological processes related to Pars Planitis according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independentGO:00024869.3HLA-A, HLA-B
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:00024809.3HLA-A, HLA-B
3positive regulation of T cell mediated cytotoxicityGO:00019169.2HLA-A, HLA-B
4type I interferon signaling pathwayGO:00603379.2HLA-A, HLA-B
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:00024799.1HLA-B, HLA-A
6antigen processing and presentation of peptide antigen via MHC class IGO:00024749.1HLA-A, HLA-B
7antigen processing and presentation of exogenous peptide antigen via MHC class IGO:00425909.0HLA-A, HLA-B
8regulation of immune responseGO:00507768.8HLA-A, HLA-B
9detection of bacteriumGO:00160458.8HLA-DRB1, HLA-A, HLA-B
10interferon-gamma-mediated signaling pathwayGO:00603338.7HLA-B, HLA-A, HLA-DRB1
11cytokine-mediated signaling pathwayGO:00192218.7HLA-B, HLA-A, HLA-DRB1
12immune responseGO:00069558.2IL1RN, HLA-DRB1, HLA-A, HLA-B

Molecular functions related to Pars Planitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1TAP bindingGO:00469779.1HLA-A, HLA-B
2peptide antigen bindingGO:00426058.2HLA-DRB1, HLA-A, HLA-B

Products for genes affiliated with Pars Planitis

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Sources for Pars Planitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet