MCID: PRS012
MIFTS: 46

Pars Planitis malady

Genetic diseases, Rare diseases, Eye diseases categories

Summaries for Pars Planitis

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Sources:
44NIH Rare Diseases, 66Wikipedia, 48OMIM, 34MalaCards
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NIH Rare Diseases:44 Pars planitis is a disease of the eye in which there is inflammation of the pars plana, a small area of tissue next to the iris that is responsible for making aqueous humor (the fluid in the eye that nourishes the lens and cornea).  pars planitis is often referred to as intermediate uveitis because the pars plana is a part of the uvea.  this condition most often affects young men and is generally not associated with any other disease or symptoms (idiopathic). however, there have been a few case reports of an association with crohn's disease, and some experts suggest a possible association with multiple sclerosis, sarcoidosis, cat scratch or lyme disease. last updated: 4/8/2012

MalaCards: Pars Planitis, also known as familial pars planitis, is related to uveitis and multiple sclerosis. An important gene associated with Pars Planitis is CD27 (CD27 molecule), and among its related pathways are TNF Signaling and Immune response IFN alpha beta signaling pathway. The compounds lipoteichoic acid and gold sodium thiomalate have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and t cells.

Wikipedia:66 Intermediate uveitis is a form of uveitis localized to the vitreous and peripheral retina. Primary sites... more...

Description from OMIM:48 606177

Aliases & Classifications for Pars Planitis

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9Disease Ontology, 44NIH Rare Diseases, 63UMLS, 48OMIM, 59SNOMED-CT, 28ICD9CM, 41NCIt, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Eye diseases


Aliases & Descriptions:

pars planitis 9 44 63
familial pars planitis 44 63
vitritis 44 63
peripheral retinal inflammation 44
uveitis, intermediate 63
intermediate uveitis 44
posterior cyclitis 9


External Ids:

Disease Ontology9 DOID:12731
OMIM48 606177
ICD9CM28 363.21
NCIt41 C34903
MeSH36 D015868
ICD1026 H30.2

Related Diseases for Pars Planitis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Pars Planitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis30.9HLA-B, HLA-A
2multiple sclerosis30.6HLA-B, HLA-A, HLA-DRB1, IL1RN, CD27
3sarcoidosis30.2IL1RN, CD27, HLA-DRB1, HLA-A
4non-hodgkin lymphoma30.0HLA-A, HLA-DRB1, CD27
5melanoma29.9CD27, HLA-DRB1, HLA-A, HLA-B
6intermediate uveitis10.5
7cataract10.4
8iridocyclitis10.4
9crohn's disease10.2
10corneal ectasia10.2
11posterior uveitis10.2
12choroiditis10.2
13cone dystrophy10.2
14optic atrophy10.2
15retinal detachment10.2
16retinitis10.2
17retinoschisis10.2
18acute zonal occult outer retinopathy10.2
19dominant optic atrophy10.2
20chorioretinitis10.2
21cytomegalovirus retinitis10.2
22retinal vasculitis10.2
23cystoid macular edema10.2
24vasculitis10.2
25dengue shock syndrome10.1IL1RN
26rubella10.1
27cat-scratch disease10.1
28granuloma annulare10.1
29acne10.1
30alopecia10.1
31alopecia areata10.1
32endophthalmitis10.1
33ankylosing spondylitis10.0HLA-B, IL1RN
34polymyalgia rheumatica10.0IL1RN, HLA-DRB1
35follicular lymphoma10.0HLA-B, CD27
36dermatomyositis10.0HLA-B, IL1RN
37polymyositis10.0HLA-B, IL1RN
38plasmodium falciparum malaria10.0HLA-B, HLA-DRB1
39myositis10.0IL1RN, HLA-B
40juvenile rheumatoid arthritis10.0HLA-DRB1, IL1RN
41tetanus10.0HLA-B, CD27
42human immunodeficiency virus infectious disease10.0CD27, HLA-A
43stevens-johnson syndrome10.0HLA-B, HLA-A
44primary biliary cirrhosis10.0HLA-DRB1, HLA-B
45behcet's disease10.0HLA-A, HLA-B
46vaccinia10.0HLA-A, HLA-B
47hemochromatosis10.0HLA-A, HLA-B
48intraocular melanoma10.0HLA-B, HLA-A
49autoimmune hepatitis10.0HLA-A, HLA-DRB1
50graft versus host disease10.0HLA-DRB1, HLA-A

Graphical network of the top 20 diseases related to Pars Planitis:



Diseases related to pars planitis

Symptoms for Pars Planitis

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Sources:
48OMIM
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Clinical features from OMIM:

606177

Drugs & Therapeutics for Pars Planitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Pars Planitis

Drug clinical trials:

Search ClinicalTrials for Pars Planitis

Search NIH Clinical Center for Pars Planitis

Search CenterWatch for Pars Planitis

Genetic Tests for Pars Planitis

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Anatomical Context for Pars Planitis

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Sources:
34MalaCards
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MalaCards organs/tissues related to Pars Planitis:

34
Eye, Retina, T cells

Animal Models for Pars Planitis or affiliated genes

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Publications for Pars Planitis

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Sources:
53PubMed
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Articles related to Pars Planitis:

(show top 50)    (show all 88)
idTitleAuthorsYear
1
Four years old, one eye, pars planitis and cataract: surgical challenges give challenging surprises. (23626571)
2013
2
Association of epiretinal membranes with macular edema in pars planitis. (24332688)
2013
3
Effects of twice-daily topical difluprednate 0.05% emulsion in a child with pars planitis. (21034305)
2011
4
Corneal ectasia secondary to peripheral endotheliopathy in a patient with classic pars planitis. (21484170)
2011
5
Acute zonal occult outer retinopathy (AZOOR) and pars planitis: a new association? (18369082)
2008
6
Pars planitis: a 20-year study of incidence, clinical features, and outcomes. (18724984)
2008
7
Pars planitis is associated with an increased frequency of effector-memory CD57+ T cells. (17475702)
2007
8
Pars planitis in children: epidemiologic, clinical, and therapeutic characteristics. (17913171)
2007
9
Pars planitis: a 20-year study of incidence, clinical features, and outcomes. (18036872)
2007
10
The enigma of pars planitis, revisited. (16564810)
2006
11
The appearance of pars planitis in multiple sclerosis. (16117323)
2005
12
Clinical symptoms and complications of pars planitis in childhood. (15849986)
2005
13
Phacoemulsification with intraocular lens implantation in cases of pars planitis. (15474816)
2004
14
Genetic polymorphism of HLA DR in a Scottish population of patients with pars planitis. (12841565)
2003
15
Pars planitis in the Mexican Mestizo population: ocular findings, treatment, and visual outcome. (12854027)
2003
16
An old crone finds a new home: Crohn's disease and pars planitis. (12789592)
2002
17
Vitrectomy for pars planitis complicated by vitreous hemorrhage: visual outcome and long-term follow-up. (11292422)
2001
18
Pars planitis: epidemiology, treatment, and association with multiple sclerosis. (11449325)
2001
19
Familial pars planitis and dominant optic atrophy. (9134550)
1997
20
Blood serum interleukin-1 receptor antagonist in pars planitis and ocular BehAset disease. (9152064)
1997
21
Coats'-like response in a patient with pars planitis. (8795387)
1996
22
Ultrasound biomicroscopy in pars planitis. (8623895)
1996
23
Pars planitis: epidemiology and clinical outcome in a large community hospital in Mexico City. (8586494)
1995
24
Pars planitis in a family. (7814201)
1994
25
Cataract extraction in patients with pars planitis. (8341504)
1993
26
Intraocular lens implantation versus no intraocular lens implantation in patients with chronic iridocyclitis and pars planitis. A randomized prospective study. (8341503)
1993
27
The association of HLA-B8, B51, DR2, and multiple sclerosis in pars planitis. (8341502)
1993
28
Intermediate uveitis: what is the significance of the pars plana exudate in 'pars planitis'? A summary. (1730374)
1992
29
Multiple sclerosis, sarcoidosis and other diseases in patients with pars planitis. (1309708)
1992
30
Treatment of pars planitis with cryotherapy. (1945296)
1991
31
Lens implant surgery in pars planitis. (2402411)
1990
32
Neovascularization of the disc in pars planitis. (1708516)
1990
33
Pars planitis in father and son. (2096359)
1990
34
Clinical and immunopathological studies of pars planitis in a family. (3257703)
1988
35
The enigma of pars planitis. (3591882)
1987
36
Pars planitis and autoimmune endotheliopathy. (3631195)
1987
37
The significance of the pars plana exudate in pars planitis. (3578463)
1987
38
Pars planitis and autoimmune endotheliopathy. (3565524)
1987
39
Pars planitis and rod-cone dystrophy. (6333906)
1983
40
Pars planitis--a demyelinating disease? (7224943)
1981
41
Pars planitis. (6963826)
1981
42
Treatment of pars planitis. I. cryotherapy. (918841)
1977
43
Pars planitis. (269542)
1977
44
Treatment of pars planitis II. corticosteroids. (918842)
1977
45
Inflammation in the region of the vitreous base. Pars planitis. (1070846)
1976
46
Cytostatics in the treatment of chronic cyclitis ('pars-planitis'). (980401)
1976
47
Origin of macular edema caused by pars planitis]. (48223)
1975
48
Fibroglial proliferation in pars planitis. (1066857)
1975
49
Iridocyclitis with hemorrhagic pars planitis due to Microfilaria bancrofti. (4675032)
1972
50
The fine structure of the vitreous base of the human eye and pathogenesis of pars planitis. (5091131)
1971

Variations for Pars Planitis

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Expression for genes affiliated with Pars Planitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pars Planitis

Search GEO for disease gene expression data for Pars Planitis.

Pathways for genes affiliated with Pars Planitis

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Sources:
51PathCards, 58SinoBiological, 55R&D Systems, 61Thomson Reuters, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 54QIAGEN
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Pathways related to Pars Planitis according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.2CD27, HLA-A
2
Show member pathways
9.1HLA-B, HLA-A
3
Show member pathways
9.1HLA-A, HLA-B
49.1HLA-A, HLA-B
5
Show member pathways
TCR signaling in naive CD8+ T cells39
9.0HLA-DRB1, HLA-A
6
Show member pathways
Immune response IL 12 induced IFN gamma production61
9.0HLA-DRB1, HLA-A
7
Show member pathways
8.5HLA-B, HLA-A, HLA-DRB1
8
Show member pathways
8.5HLA-DRB1, HLA-A, HLA-B
98.5HLA-DRB1, HLA-A, HLA-B
108.5HLA-B, HLA-A, HLA-DRB1
118.5HLA-B, HLA-A, HLA-DRB1
12
Show member pathways
8.5HLA-DRB1, HLA-A, HLA-B
13
Show member pathways
8.5HLA-B, HLA-A, HLA-DRB1
148.5HLA-DRB1, HLA-A, HLA-B
15
Show member pathways
8.0IL1RN, HLA-DRB1, HLA-A, HLA-B

Compounds for genes affiliated with Pars Planitis

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Pars Planitis according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1lipoteichoic acid469.8IL1RN, HLA-B
2gold sodium thiomalate469.7IL1RN, HLA-DRB1
3latex469.6IL1RN, HLA-B
4allergens469.6HLA-DRB1, IL1RN
5p003469.6IL1RN, HLA-B
6allopurinol46 52 1211.5HLA-A, HLA-B
7ursodeoxycholic acid46 25 1211.4HLA-A, HLA-B
8carbamazepine46 52 1211.4HLA-A, HLA-B
9dr-10469.4HLA-DRB1, HLA-A
10carbohydrates469.3HLA-B, IL1RN
11p002469.2IL1RN, HLA-A
12endotoxin469.1IL1RN, HLA-B
135-aza-2deoxycytidine469.1HLA-A, HLA-B
14cyclosporin a46 30 6210.9HLA-B, HLA-A, IL1RN
15adenylate468.9IL1RN, HLA-A, HLA-B
16atp46 309.8IL1RN, HLA-DRB1, HLA-B
17zinc46 259.8HLA-B, HLA-A, IL1RN
18oligonucleotide468.8HLA-DRB1, HLA-A, HLA-B
19arginine468.7HLA-DRB1, HLA-A, HLA-B
20alanine468.6HLA-A, HLA-DRB1, IL1RN
21calcium46 52 25 1211.4HLA-B, HLA-A, IL1RN, CD27
22tyrosine468.3HLA-B, HLA-A, HLA-DRB1, IL1RN

GO Terms for genes affiliated with Pars Planitis

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17Gene Ontology
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Cellular components related to Pars Planitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:0426129.2HLA-A, HLA-B
2early endosome membraneGO:0319019.1HLA-A, HLA-B
3phagocytic vesicle membraneGO:0306708.8HLA-A, HLA-B
4integral component of lumenal side of endoplasmic reticulum membraneGO:0715568.7HLA-DRB1, HLA-A, HLA-B
5ER to Golgi transport vesicle membraneGO:0125078.7HLA-B, HLA-A, HLA-DRB1
6Golgi membraneGO:0001398.4HLA-B, HLA-A, HLA-DRB1
7integral component of plasma membraneGO:0058878.1HLA-B, HLA-A, HLA-DRB1, CD27
8extracellular vesicular exosomeGO:0700628.0IL1RN, HLA-DRB1, HLA-A, HLA-B

Biological processes related to Pars Planitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independentGO:0024869.3HLA-A, HLA-B
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:0024809.3HLA-A, HLA-B
3positive regulation of T cell mediated cytotoxicityGO:0019169.2HLA-A, HLA-B
4type I interferon signaling pathwayGO:0603379.2HLA-A, HLA-B
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:0024799.1HLA-B, HLA-A
6antigen processing and presentation of peptide antigen via MHC class IGO:0024749.1HLA-A, HLA-B
7antigen processing and presentation of exogenous peptide antigen via MHC class IGO:0425909.0HLA-A, HLA-B
8regulation of immune responseGO:0507768.8HLA-A, HLA-B
9detection of bacteriumGO:0160458.8HLA-DRB1, HLA-A, HLA-B
10interferon-gamma-mediated signaling pathwayGO:0603338.7HLA-B, HLA-A, HLA-DRB1
11cytokine-mediated signaling pathwayGO:0192218.7HLA-B, HLA-A, HLA-DRB1
12immune responseGO:0069558.2IL1RN, HLA-DRB1, HLA-A, HLA-B

Molecular functions related to Pars Planitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1TAP bindingGO:0469779.1HLA-A, HLA-B
2peptide antigen bindingGO:0426058.2HLA-DRB1, HLA-A, HLA-B

Products for genes affiliated with Pars Planitis

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Sources for Pars Planitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet