MCID: PRS012
MIFTS: 43

Pars Planitis malady

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Pars Planitis

Aliases & Descriptions for Pars Planitis:

Name: Pars Planitis 12 50 42 14 69
Vitritis 50 69
Peripheral Retinal Inflammation 50
Uveitis, Intermediate 69
Intermediate Uveitis 50
Posterior Cyclitis 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:12731
ICD10 33 H30.2
ICD9CM 35 363.21
MeSH 42 D015868
NCIt 47 C34903
UMLS 69 C0030593

Summaries for Pars Planitis

NIH Rare Diseases : 50 pars planitis is a disease of the eye that is characterized by inflammation of the narrowed area (pars plana) between the colored part of the eye (iris) and the choroid. this may lead to blurred vision; dark, floating spots in the vision; and progressive vision loss. as the condition advances, cataracts, retinal detachment, or macular edema (fluid within the retina) may develop. pars planitis most often affects young men and is generally not associated with any other disease or symptoms (idiopathic); however, it can be associated with other autoimmune conditions such as multiple sclerosis and sarcoidosis. treatment typically includes corticosteroid drugs, immunosuppressive medications, and/or surgery. last updated: 6/23/2015

MalaCards based summary : Pars Planitis, also known as vitritis, is related to intermediate uveitis and retinal vasculitis. An important gene associated with Pars Planitis is HLA-A (Major Histocompatibility Complex, Class I, A), and among its related pathways/superpathways are Allograft rejection and Influenza A. The drugs Azathioprine and Chlorambucil have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and t cells, and related phenotype is Increased shRNA abundance (Z-score > 2).

Wikipedia : 71 Intermediate uveitis is a form of uveitis localized to the vitreous and peripheral retina. Primary sites... more...

Related Diseases for Pars Planitis

Diseases related to Pars Planitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
id Related Disease Score Top Affiliating Genes
1 intermediate uveitis 11.4
2 retinal vasculitis 11.1
3 uveitis 10.2
4 cerebral sarcoidosis 10.2 HLA-A HLA-DRB1
5 patau syndrome 10.2 HLA-A HLA-DRB1
6 peripheral artery disease 10.1 HLA-A HLA-DRB1
7 depressed scar 10.1 HLA-A HLA-DRB1
8 immunoglobulin g deficiency 10.1 HLA-DRB1 IL1RN
9 stiff-person syndrome 10.1 HLA-DRB1 IL1RN
10 retinitis 10.1
11 retinal detachment 10.1
12 b-cell lymphomas 10.1 HLA-A HLA-DRB1
13 periodontosis 10.1 HLA-A IL1RN
14 immune deficiency, familial variable 10.0 HLA-B HLA-DRB1
15 mirizzi syndrome 10.0 HLA-B HLA-DRB1
16 swine influenza 10.0 HLA-B HLA-DRB1
17 solid pseudopapillary carcinoma of pancreas 10.0 HLA-A HLA-B
18 cervical adenoid basal carcinoma 10.0 HLA-B HLA-DRB1
19 myopathy, congenital nonprogressive, with moebius sequence and robin sequence 10.0 HLA-A HLA-B
20 epididymo-orchitis 10.0 HLA-A HLA-B
21 cryptococcosis 10.0 HLA-B HLA-DRB1
22 aortic coarctation 10.0 HLA-A HLA-B
23 bubonic plague 10.0 HLA-A HLA-B
24 colorectal cancer, hereditary nonpolyposis, type 6 10.0 HLA-A HLA-B
25 disease of mental health 10.0 HLA-B HLA-DRB1
26 iridocyclitis 10.0
27 retinoschisis 10.0
28 cataract 10.0
29 mastitis 10.0 HLA-A HLA-B
30 intracranial hemorrhage in brain cerebrovascular malformations 10.0 HLA-DRB1 IL1RN
31 orbital osteomyelitis 10.0 HLA-A HLA-B
32 central nervous system lymphoma 10.0 HLA-A HLA-B
33 motility-related diarrhea 10.0 HLA-A HLA-DRB1 IL1RN
34 autosomal recessive congenital methemoglobinemia 10.0 HLA-A HLA-B
35 acute cholangitis 10.0 HLA-B HLA-DRB1
36 psoriasis susceptibility 1 10.0 HLA-A HLA-B
37 bone angioendothelial sarcoma 10.0 HLA-DRB1 IL1RN
38 bacterial meningitis 9.9 HLA-B HLA-DRB1
39 celiac disease 9.9 HLA-B IL1RN
40 respiratory system disease 9.9 HLA-B HLA-DRB1
41 endobronchial leiomyoma 9.9 HLA-B IL1RN
42 sacral nerve root cysts 9.9 HLA-A HLA-B HLA-DRB1
43 learning disability 9.9 HLA-A HLA-B HLA-DRB1
44 nystagmus, congenital motor, autosomal recessive 9.9 HLA-A HLA-B HLA-DRB1
45 aseptic meningitis 9.9 HLA-A HLA-B HLA-DRB1
46 acanthoma 9.9 HLA-A HLA-B HLA-DRB1
47 bickerstaff brainstem encephalitis 9.9 HLA-A HLA-B HLA-DRB1
48 hepatitis 9.9 HLA-A HLA-B HLA-DRB1
49 anaerobic meningitis 9.9 HLA-A HLA-B HLA-DRB1
50 folinic acid-responsive seizures 9.9 HLA-A HLA-B HLA-DRB1

Graphical network of the top 20 diseases related to Pars Planitis:



Diseases related to Pars Planitis

Symptoms & Phenotypes for Pars Planitis

GenomeRNAi Phenotypes related to Pars Planitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.88 HLA-B HLA-A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.88 HLA-B HLA-A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.88 HLA-A HLA-B
4 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.88 HLA-B HLA-A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.88 HLA-B HLA-A
6 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.88 HLA-B HLA-A
7 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.88 HLA-B HLA-A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.88 HLA-B HLA-A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.88 HLA-B HLA-A

Drugs & Therapeutics for Pars Planitis

Drugs for Pars Planitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 94)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azathioprine Approved Phase 4 446-86-6 2265
2
Chlorambucil Approved Phase 4 305-03-3 2708
3
Cyclophosphamide Approved, Investigational Phase 4 50-18-0, 6055-19-2 2907
4
Cyclosporine Approved, Investigational, Vet_approved Phase 4 79217-60-0, 59865-13-3 5284373 6435893
5
Daclizumab Approved, Investigational Phase 4 152923-56-3
6
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 4,Phase 3 67-73-2 6215
7
Infliximab Approved Phase 4,Phase 1,Phase 2 170277-31-3
8
Methotrexate Approved Phase 4,Phase 3,Phase 1,Phase 2 1959-05-2, 59-05-2 126941
9
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3 128794-94-5 5281078
10
Mycophenolic acid Approved Phase 4,Phase 3 24280-93-1 446541
11
Prednisone Approved, Vet_approved Phase 4,Phase 3 53-03-2 5865
12
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
13
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-02-2 5743
14 Immunosuppressive Agents Phase 4,Phase 3,Phase 1,Phase 2
15 Alkylating Agents Phase 4
16 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
17 Antimetabolites Phase 4,Phase 3,Phase 1,Phase 2
18 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 1,Phase 2
19 Antineoplastic Agents, Alkylating Phase 4
20 Antirheumatic Agents Phase 4,Phase 3,Phase 1,Phase 2
21 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
22 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
23 Hormones Phase 4,Phase 3,Phase 2,Phase 1
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
25 Adrenocorticotropic Hormone Phase 4,Phase 2
26 beta-endorphin Phase 4,Phase 2
27 Melanocyte-Stimulating Hormones Phase 4,Phase 2
28 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1
29 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1
30 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
31 BB 1101 Phase 4,Phase 2,Phase 3,Phase 1
32 Dexamethasone 21-phosphate Phase 4,Phase 2,Phase 3,Phase 1
33 Dexamethasone acetate Phase 4,Phase 2,Phase 3,Phase 1 1177-87-3
34 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
35 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3
36 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
37
protease inhibitors Phase 4,Phase 2,Phase 3
38 Pharmaceutical Solutions Phase 4,Phase 3,Phase 1,Phase 2
39 Gramicidin Phase 4
40 Ophthalmic Solutions Phase 4
41 Polymyxin B Phase 4
42 Polymyxins Phase 4
43
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
44
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
45
Adalimumab Approved Phase 3 331731-18-1 16219006
46
Difluprednate Approved Phase 3 23674-86-4 443936
47
Triamcinolone Approved, Vet_approved Phase 3,Phase 1,Phase 2 124-94-7 31307
48
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 1,Phase 2 59-30-3 6037
49
leucovorin Approved, Nutraceutical Phase 3,Phase 1,Phase 2 58-05-9 54575, 6560146 143
50 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 56)
id Name Status NCT ID Phase
1 Multicenter Uveitis Steroid Treatment (MUST) Trial Completed NCT00132691 Phase 4
2 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4
3 Study of the Effectiveness of Ozurdex for the Control of Uveitis Recruiting NCT02049476 Phase 4
4 Frozen Versus Fresh Corneal Carriers for the Boston KPro Type I Donor Carriers Enrolling by invitation NCT01950598 Phase 4
5 Myfortic for the Treatment of Non-infectious Intermediate Uveitis Completed NCT01092533 Phase 3
6 Randomized, Controlled Trial to Test the Efficacy of Interferon Beta in the Treatment of Intermediate Uveitis Completed NCT00344253 Phase 3
7 Efficacy and Safety of Adalimumab in Subjects With Inactive Uveitis Completed NCT01124838 Phase 3
8 A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Intermediate or Posterior Uveitis Completed NCT00333814 Phase 2, Phase 3
9 Efficacy and Safety of Adalimumab in Patients With Active Uveitis Completed NCT01138657 Phase 3
10 Phase III Study in Refractory Behcet's Disease Completed NCT00995709 Phase 3
11 A Study of LX211 in Clinically Quiescent Non-infectious Intermediate, Anterior and Intermediate, Posterior or Pan-Uveitis Completed NCT00404742 Phase 3
12 A Study of LX211 in Active Sight Threatening, Non-infectious Intermediate-, Anterior and Intermediate-, Posterior-, or Pan-Uveitis Completed NCT00404612 Phase 3
13 Difluprednate Pediatric Study for the Treatment of Inflammation Post-Cataract Surgery Completed NCT01124045 Phase 3
14 Suprachoroidal Injection of CLS-TA in Subjects Non-infectious Uveitis Recruiting NCT03097315 Phase 3
15 Suprachoroidal Injection of CLS-TA in Subjects With Macular Edema Associated With Non-infectious Uveitis Recruiting NCT02595398 Phase 3
16 A Controlled, Multi-center Study of the Utilization and Safety of the MK II Inserter and the Safety of the FAI Insert in Subjects With Non-infectious Uveitis Affecting the Posterior Segment of the Eye Active, not recruiting NCT02748512 Phase 3
17 Safety and Efficacy Study of a Fluocinolone Acetonide Intravitreal (FAI) Insert in Subjects With Chronic Non-infectious Posterior Uveitis Active, not recruiting NCT02746991 Phase 3
18 Safety and Efficacy of an Injectable Fluocinolone Acetonide Intravitreal Insert Active, not recruiting NCT01694186 Phase 3
19 A Study of the Long-term Safety and Efficacy of Adalimumab in Subjects With Intermediate-, Posterior-, or Pan-uveitis Active, not recruiting NCT01148225 Phase 3
20 Safety and Efficacy of AIN457 in Patients With Active Non-infectious Uveitis Terminated NCT01095250 Phase 3
21 Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis Terminated NCT01032915 Phase 3
22 38 Week Extension Study to CAIN457C2303 Terminated NCT01093846 Phase 3
23 Extension Study to Assess Safety and Efficacy of AIN457 in Patients With Active Non-infectious Uveitis Terminated NCT01103024 Phase 3
24 Long-term Safety of Gevokizumab in the Treatment of Patients With Chronic Non-infectious Uveitis (EYEGUARD-X) Terminated NCT02375685 Phase 3
25 Safety and Efficacy Study of Gevokizumab to Treat Non-infectious Uveitis Controlled With Systemic Treatment Terminated NCT01747538 Phase 3
26 Safety and Efficacy Study of Gevokizumab to Treat Active Non-infectious Uveitis Terminated NCT01684345 Phase 3
27 An Open-label, Rollover Study Providing Continued Dosing of Gevokizumab in Order to Assess Long-term Gevokizumab Safety Data Terminated NCT02258854 Phase 3
28 Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis Terminated NCT01090310 Phase 3
29 Study to Evaluate the Long Term Use of Treatment With AIN457 for Uveitis Withdrawn NCT01327664 Phase 3
30 Safety, Tolerability, and Efficacy of AEB071 in the Treatment of Uveitis Completed NCT00615693 Phase 2
31 Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat Uveitis Completed NCT01789320 Phase 1, Phase 2
32 Topical Interferon Gamma for Macular Edema Secondary to Uveitis Completed NCT01376362 Phase 1, Phase 2
33 Suprachoroidal Injection of Triamcinolone Acetonide in Subjects With Macular Edema Following Non-Infectious Uveitis Completed NCT02255032 Phase 2
34 Intravitreal Infliximab in Refractory Uveitis in Behcet's Disease: A Safety and Efficacy Clinical Study Completed NCT02620618 Phase 1, Phase 2
35 Leflunomide to Treat Uveitis Completed NCT00001863 Phase 2
36 Safety and Efficacy of AIN457 in Noninfectious Uveitis Completed NCT00685399 Phase 2
37 Safety,Tolerability and Efficacy of Intravitreal LFG316 in Patients With Active Non-infectious Intermediate-, posterior-or Panuveitis , Recruiting NCT01526889 Phase 2
38 Intravitreal Sirolimus as Therapeutic Approach to Uveitis Recruiting NCT01280669 Phase 2
39 Ustekinumab (STELARA ) for the Treatment of Active Sight-Threatening Uveitis Recruiting NCT02911116 Phase 2
40 Vision Restoration With a Collagen Crosslinked Boston Keratoprosthesis Unit Recruiting NCT02863809 Phase 1, Phase 2
41 Study of the Safety, Tolerability, and Bioactivity of Tocilizumab On Patients With Non-infectious UVEITIS: The STOP-UVEITIS Study Active, not recruiting NCT01717170 Phase 1, Phase 2
42 Safety &Efficacy of CF101 to Subjects With Uveitis Not yet recruiting NCT01905124 Phase 2
43 ACTH as A Re-emerging theRapy for Uveitis (The ACTHAR Study) Not yet recruiting NCT02931175 Phase 2
44 Safety and Preliminary Efficacy Study of V404 PDS in Uveitis Terminated NCT02125266 Phase 1, Phase 2
45 A Phase I/IIa Study for the Treatment of Uveitis With Iontophoresis Withdrawn NCT00499551 Phase 1, Phase 2
46 Sirolimus as Therapeutic Approach to Uveitis Unknown status NCT00908466 Phase 1
47 The Treatment of Uveitic Cystoid Macular Edema With Topical Interferon Gamma Completed NCT00943982 Phase 1
48 Quality of Life in Patients With Intermediate Uveitis Completed NCT01314469
49 Retisert and Cataract Surgery in Patients With Severe Uveitis Completed NCT00570830
50 Assessment of Retinal Nerve Fibre Layer by Optical Coherence Tomography in Uveitis Patients With Papilloedema Completed NCT01170481

Search NIH Clinical Center for Pars Planitis

Cochrane evidence based reviews: pars planitis

Genetic Tests for Pars Planitis

Anatomical Context for Pars Planitis

MalaCards organs/tissues related to Pars Planitis:

39
Eye, Retina, T Cells

Publications for Pars Planitis

Articles related to Pars Planitis:

(show top 50) (show all 96)
id Title Authors Year
1
Peripheral Cryoablation for Treatment of Active Pars Planitis: Long-Term Outcomes of a Retrospective Study. ( 26576712 )
2016
2
Retinoschisis in Pars Planitis. ( 26902143 )
2016
3
Scleral Buckling for Rhegmatogenous Retinal Detachment Associated with Pars Planitis. ( 27688907 )
2016
4
Rhegmatogenous retinal detachment due to a macular hole in a patient with pars planitis: a case report. ( 25565856 )
2015
5
A 12-Year-Old Boy with Pars Planitis. ( 26587811 )
2015
6
Immunopathogenic Background of Pars Planitis. ( 26438050 )
2015
7
Pars Planitis: Epidemiology, Clinical Characteristics, Management and Visual Prognosis. ( 27051493 )
2015
8
Treatment with immunosuppressive therapy in patients with pars planitis: experience of a reference centre in Mexico. ( 24985727 )
2014
9
Peripapillary choroidal neovascularization in pars planitis. ( 23514324 )
2013
10
Four years old, one eye, pars planitis and cataract: surgical challenges give challenging surprises. ( 23626571 )
2013
11
Association of epiretinal membranes with macular edema in pars planitis. ( 24332688 )
2013
12
Corneal ectasia secondary to peripheral endotheliopathy in a patient with classic pars planitis. ( 21484170 )
2011
13
Childhood pars planitis; clinical features and outcomes. ( 22454747 )
2011
14
Effects of twice-daily topical difluprednate 0.05% emulsion in a child with pars planitis. ( 21034305 )
2011
15
[Clinical and epidemiological features and HLA association in patients with pars planitis]. ( 20537664 )
2010
16
Peptidic sequence "HSEAETGPP" is recognized by the sera of pars planitis patients. ( 19480736 )
2009
17
Pars planitis: a 20-year study of incidence, clinical features, and outcomes. ( 18724984 )
2008
18
Acute zonal occult outer retinopathy (AZOOR) and pars planitis: a new association? ( 18369082 )
2008
19
Pars planitis in children: epidemiologic, clinical, and therapeutic characteristics. ( 17913171 )
2007
20
Pars planitis: a 20-year study of incidence, clinical features, and outcomes. ( 18036872 )
2007
21
Pars planitis is associated with an increased frequency of effector-memory CD57+ T cells. ( 17475702 )
2007
22
The enigma of pars planitis, revisited. ( 16564810 )
2006
23
Clinical symptoms and complications of pars planitis in childhood. ( 15849986 )
2005
24
Valsalva retinopathy: diagnostic challenges in a patient with pars-planitis. ( 15799745 )
2005
25
The appearance of pars planitis in multiple sclerosis. ( 16117323 )
2005
26
Elevated levels of interleukin 6 in the vitreous fluid of patients with pars planitis and posterior uveitis: the Massachusetts eye & ear experience and review of previous studies. ( 15385196 )
2004
27
Phacoemulsification with intraocular lens implantation in cases of pars planitis. ( 15474816 )
2004
28
Pars planitis in the Mexican Mestizo population: ocular findings, treatment, and visual outcome. ( 12854027 )
2003
29
Classic Pars Planitis: strong correlation of class II genes with gender and some clinical features in Mexican Mestizos. ( 14522094 )
2003
30
Genetic polymorphism of HLA DR in a Scottish population of patients with pars planitis. ( 12841565 )
2003
31
Peripheral retinoschisis and exudative retinal detachment in pars planitis. ( 12476097 )
2002
32
An old crone finds a new home: Crohn's disease and pars planitis. ( 12789592 )
2002
33
Grading of pars planitis by ultrasound biomicroscopy--echographic and clinical study. ( 12423740 )
2002
34
Vitreous hemorrhage is a common complication of pediatric pars planitis. ( 11772586 )
2002
35
Vitrectomy for pars planitis complicated by vitreous hemorrhage: visual outcome and long-term follow-up. ( 11292422 )
2001
36
Pars planitis: epidemiology, treatment, and association with multiple sclerosis. ( 11449325 )
2001
37
The association of HLA class II with pars planitis. ( 11336946 )
2001
38
Pars planitis: a comparison of childhood onset and adult onset disease. ( 11341451 )
2001
39
Ultrasound biomicroscopy in the diagnosis and management of pars planitis caused by caterpillar hairs. ( 11004275 )
2000
40
Visual outcomes after pars plana vitrectomy for epiretinal membranes associated with pars planitis. ( 10366075 )
1999
41
Pars planitis: clinical features and class II HLA associations. ( 10080220 )
1999
42
Coats'-like response in pars planitis. ( 10048380 )
1999
43
Intermediate uveitis of pars planitis type in identical twins. Report of a case. ( 10826543 )
1998
44
Results of peripheral laser photocoagulation in pars planitis. ( 10360286 )
1998
45
Blood serum interleukin-1 receptor antagonist in pars planitis and ocular BehAset disease. ( 9152064 )
1997
46
Familial pars planitis and dominant optic atrophy. ( 9134550 )
1997
47
Coats'-like response in a patient with pars planitis. ( 8795387 )
1996
48
Ultrasound biomicroscopy in pars planitis. ( 8623895 )
1996
49
Identification, quantitation, and purification of a 36 kDa circulating protein associated with active pars planitis. ( 8759356 )
1996
50
Peripheral corneal endotheliopathy and pars planitis. ( 22823324 )
1996

Variations for Pars Planitis

Expression for Pars Planitis

Search GEO for disease gene expression data for Pars Planitis.

Pathways for Pars Planitis

GO Terms for Pars Planitis

Cellular components related to Pars Planitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.85 CD27 HLA-A HLA-B HLA-DRB1 IL1RN
2 plasma membrane GO:0005886 9.85 CCR7 CD27 HLA-A HLA-B HLA-DRB1 IL1RN
3 Golgi membrane GO:0000139 9.65 HLA-A HLA-B HLA-DRB1
4 external side of plasma membrane GO:0009897 9.5 CCR7 CD27 HLA-DRB1
5 phagocytic vesicle membrane GO:0030670 9.43 HLA-A HLA-B
6 recycling endosome membrane GO:0055038 9.4 HLA-A HLA-B
7 cell surface GO:0009986 9.35 CCR7 CD27 HLA-A HLA-B HLA-DRB1
8 ER to Golgi transport vesicle membrane GO:0012507 9.33 HLA-A HLA-B HLA-DRB1
9 MHC class I protein complex GO:0042612 9.26 HLA-A HLA-B
10 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.8 HLA-A HLA-B HLA-DRB1

Biological processes related to Pars Planitis according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.67 HLA-A HLA-B HLA-DRB1
2 viral process GO:0016032 9.61 HLA-A HLA-B HLA-DRB1
3 inflammatory response GO:0006954 9.58 CCR7 CD27 IL1RN
4 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.51 HLA-A HLA-B
5 positive regulation of JNK cascade GO:0046330 9.48 CCR7 CD27
6 type I interferon signaling pathway GO:0060337 9.46 HLA-A HLA-B
7 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.37 HLA-A HLA-B
8 interferon-gamma-mediated signaling pathway GO:0060333 9.33 HLA-A HLA-B HLA-DRB1
9 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.32 HLA-A HLA-B
10 protection from natural killer cell mediated cytotoxicity GO:0042270 9.26 HLA-A HLA-B
11 antigen processing and presentation GO:0019882 9.13 HLA-A HLA-B HLA-DRB1
12 immune response GO:0006955 9.1 CCR7 CD27 HLA-A HLA-B HLA-DRB1 IL1RN

Molecular functions related to Pars Planitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.8 HLA-A HLA-B HLA-DRB1

Sources for Pars Planitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
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28 GO
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33 ICD10
34 ICD10 via Orphanet
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42 MeSH
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54 OMIM
55 OMIM via Orphanet
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70 UMLS via Orphanet
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