MCID: PRS012
MIFTS: 43

Pars Planitis malady

Eye diseases, Genetic diseases categories

Summaries for Pars Planitis

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Sources:
42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Pars planitis is a disease of the eye in which there is inflammation of the pars plana, a small area of tissue next to the iris that is responsible for making aqueous humor (the fluid in the eye that nourishes the lens and cornea).  pars planitis is often referred to as intermediate uveitis because the pars plana is a part of the uvea.  this condition most often affects young men and is generally not associated with any other disease or symptoms (idiopathic). however, there have been a few case reports of an association with crohn's disease, and some experts suggest a possible association with multiple sclerosis, sarcoidosis, cat scratch or lyme disease. last updated: 4/8/2012

MalaCards: Pars Planitis, also known as familial pars planitis, is related to uveitis and multiple sclerosis. An important gene associated with Pars Planitis is CD27 (CD27 molecule), and among its related pathways are HTLV-I infection and Immune response IFN alpha/beta signaling pathway. The compounds lipoteichoic acid and gold sodium thiomalate have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and t cells.

Wikipedia:63 Intermediate uveitis is a form of uveitis localized to the vitreous and peripheral retina. Primary sites... more...

Description from OMIM:46 606177

Aliases & Classifications for Pars Planitis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 46OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Eye diseases


Aliases & Descriptions:

pars planitis 8 42 60
familial pars planitis 42 60
vitritis 42 60
peripheral retinal inflammation 42
uveitis, intermediate 60
intermediate uveitis 42
posterior cyclitis 8


External Ids:

Disease Ontology8 DOID:12731
MeSH34 D015868
ICD9CM27 363.21
NCIt39 C34903
OMIM46 606177
ICD1025 H30.2

Related Diseases for Pars Planitis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Pars Planitis:



Diseases related to pars planitis

Clinical Features for Pars Planitis

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Sources:
46OMIM
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Clinical features from OMIM:

606177

Drugs & Therapeutics for Pars Planitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Pars Planitis

Search CenterWatch for Pars Planitis

Genetic Tests for Pars Planitis

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Anatomical Context for Pars Planitis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Pars Planitis:

32
Eye, Retina, T cells

Animal Models for Pars Planitis or affiliated genes

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Publications for Pars Planitis

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Sources:
50PubMed
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Articles related to Pars Planitis:

(show top 50)    (show all 88)
idTitleAuthorsYear
1
Peripapillary choroidal neovascularization in pars planitis. (23514324)
2013
2
Effects of twice-daily topical difluprednate 0.05% emulsion in a child with pars planitis. (21034305)
2011
3
Childhood pars planitis; clinical features and outcomes. (22454747)
2011
4
Pars planitis in children: epidemiologic, clinical, and therapeutic characteristics. (17913171)
2007
5
Pars planitis: a 20-year study of incidence, clinical features, and outcomes. (18036872)
2007
6
The enigma of pars planitis, revisited. (16564810)
2006
7
The appearance of pars planitis in multiple sclerosis. (16117323)
2005
8
Valsalva retinopathy: diagnostic challenges in a patient with pars-planitis. (15799745)
2005
9
Elevated levels of interleukin 6 in the vitreous fluid of patients with pars planitis and posterior uveitis: the Massachusetts eye & ear experience and review of previous studies. (15385196)
2004
10
Classic Pars Planitis: strong correlation of class II genes with gender and some clinical features in Mexican Mestizos. (14522094)
2003
11
Pars planitis: epidemiology, treatment, and association with multiple sclerosis. (11449325)
2001
12
The association of HLA class II with pars planitis. (11336946)
2001
13
Ultrasound biomicroscopy in the diagnosis and management of pars planitis caused by caterpillar hairs. (11004275)
2000
14
Visual outcomes after pars plana vitrectomy for epiretinal membranes associated with pars planitis. (10366075)
1999
15
Intermediate uveitis of pars planitis type in identical twins. Report of a case. (10826543)
1998
16
Results of peripheral laser photocoagulation in pars planitis. (10360286)
1998
17
Familial pars planitis and dominant optic atrophy. (9134550)
1997
18
Blood serum interleukin-1 receptor antagonist in pars planitis and ocular BehAset disease. (9152064)
1997
19
Ultrasound biomicroscopy in pars planitis. (8623895)
1996
20
Peripheral corneal endotheliopathy and pars planitis. (22823324)
1996
21
Identification, quantitation, and purification of a 36 kDa circulating protein associated with active pars planitis. (8759356)
1996
22
Pars planitis: epidemiology and clinical outcome in a large community hospital in Mexico City. (8586494)
1995
23
Familial pars planitis. (7648038)
1995
24
A fluorescein angiographic study of patients with pars planitis and peripheral exudation (snowbanking) before and after cryopexy. (8035990)
1994
25
Cataract extraction in patients with pars planitis. (8341504)
1993
26
Intraocular lens implantation versus no intraocular lens implantation in patients with chronic iridocyclitis and pars planitis. A randomized prospective study. (8341503)
1993
27
Intermediate uveitis: what is the significance of the pars plana exudate in 'pars planitis'? A summary. (1730374)
1992
28
Multiple sclerosis, sarcoidosis and other diseases in patients with pars planitis. (1309708)
1992
29
Ciclosporin (Sandimmun) therapy: experience in the treatment of pars planitis and present therapeutic guidelines. (1730354)
1992
30
Intermediate uveitis: history, terminology, definition pars planitis: systemic disease associations. (1730370)
1992
31
Treatment of pars planitis with cryotherapy. (1945296)
1991
32
Lens implant surgery in pars planitis. (2402411)
1990
33
Neovascularization of the disc in pars planitis. (1708516)
1990
34
Clinical and immunopathological studies of pars planitis in a family. (3257703)
1988
35
The enigma of pars planitis. (3591882)
1987
36
Pars planitis and autoimmune endotheliopathy. (3631195)
1987
37
The significance of the pars plana exudate in pars planitis. (3578463)
1987
38
Pars planitis and autoimmune endotheliopathy. (3777084)
1986
39
Familial pars planitis. (6635352)
1983
40
Vitreous fluorophotometry in pars planitis. (6824051)
1983
41
Pars planitis--a demyelinating disease? (7224943)
1981
42
Pars planitis. (6963826)
1981
43
Familial pars planitis. (7258948)
1981
44
Electrophysiologic changes in chronic pars planitis. (7223823)
1981
45
Treatment of pars planitis. I. cryotherapy. (918841)
1977
46
Treatment of pars planitis II. corticosteroids. (918842)
1977
47
Inflammation in the region of the vitreous base. Pars planitis. (1070846)
1976
48
Cytostatics in the treatment of chronic cyclitis ('pars-planitis'). (980401)
1976
49
Fibroglial proliferation in pars planitis. (1066857)
1975
50
The fine structure of the vitreous base of the human eye and pathogenesis of pars planitis. (5091131)
1971

Genetic Variations for Pars Planitis

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Expression for genes affiliated with Pars Planitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pars Planitis

Search GEO for disease gene expression data for Pars Planitis.

Pathways for genes affiliated with Pars Planitis

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Sources:
29KEGG, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN
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Pathways related to Pars Planitis according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0HLA-B
2
Immune response IFN alpha/beta signaling pathway
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9.1HLA-A, HLA-B
39.1HLA-A, HLA-B
4
Hide members
9.1HLA-B, HLA-A
59.1HLA-B, HLA-A
6
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9.0HLA-A, HLA-DRB1
7
Hide members
9.0HLA-A, HLA-DRB1
88.5HLA-B, HLA-DRB1, HLA-A
9
Hide members
8.5HLA-B, HLA-DRB1, HLA-A
108.5HLA-A, HLA-DRB1, HLA-B
11
Hide members
8.5HLA-A, HLA-DRB1, HLA-B
12
Hide members
8.5HLA-A, HLA-DRB1, HLA-B
138.5HLA-A, HLA-DRB1, HLA-B
14
Hide members
8.0HLA-B, HLA-DRB1, HLA-A, IL1RN
15
Hide members
8.0IL1RN, HLA-A, HLA-DRB1, HLA-B

Compounds for genes affiliated with Pars Planitis

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Pars Planitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1lipoteichoic acid449.5HLA-B, IL1RN
2gold sodium thiomalate449.5IL1RN, HLA-DRB1
3allergens449.3IL1RN, HLA-DRB1
4dr-10449.2HLA-A, HLA-DRB1
5ursodeoxycholic acid44 11 2411.1HLA-B, HLA-A
6cyclosporin a44 28 5910.7IL1RN, HLA-A, HLA-B
7adenylate448.5IL1RN, HLA-A, HLA-B
8tyrosine447.7HLA-B, HLA-DRB1, HLA-A, IL1RN

GO Terms for genes affiliated with Pars Planitis

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16Gene Ontology
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Cellular components related to Pars Planitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:0426129.2HLA-A, HLA-B
2early endosome membraneGO:0319019.1HLA-A, HLA-B
3phagocytic vesicle membraneGO:0306709.0HLA-A, HLA-B
4integral to lumenal side of endoplasmic reticulum membraneGO:0715568.7HLA-A, HLA-DRB1, HLA-B
5ER to Golgi transport vesicle membraneGO:0125078.6HLA-B, HLA-DRB1, HLA-A
6Golgi membraneGO:0001398.2HLA-A, HLA-DRB1, HLA-B
7integral to plasma membraneGO:0058878.1HLA-B, HLA-DRB1, HLA-A, CD27

Biological processes related to Pars Planitis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:0024809.2HLA-B, HLA-A
2positive regulation of T cell mediated cytotoxicityGO:0019169.1HLA-A, HLA-B
3antigen processing and presentation of exogenous peptide antigen via MHC class IGO:0425909.1HLA-A, HLA-B
4type I interferon-mediated signaling pathwayGO:0603379.0HLA-B, HLA-A
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:0024798.8HLA-A, HLA-B
6detection of bacteriumGO:0160458.7HLA-A, HLA-DRB1, HLA-B
7interferon-gamma-mediated signaling pathwayGO:0603338.7HLA-A, HLA-DRB1, HLA-B
8cytokine-mediated signaling pathwayGO:0192218.6HLA-A, HLA-DRB1, HLA-B
9immune responseGO:0069558.2HLA-B, HLA-DRB1, HLA-A, IL1RN

Molecular functions related to Pars Planitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:0426058.5HLA-A, HLA-DRB1, HLA-B

Products for genes affiliated with Pars Planitis

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Pars Planitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet