MCID: PRS012
MIFTS: 39

Pars Planitis malady

Eye, Genetic categories

Summaries for Pars Planitis

Sources:
43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Pars planitis is a disease of the eye in which there is inflammation of the pars plana, a small area of tissue next to the iris that is responsible for making aqueous humor (the fluid in the eye that nourishes the lens and cornea).  pars planitis is often referred to as intermediate uveitis because the pars plana is a part of the uvea.  this condition most often affects young men and is generally not associated with any other disease or symptoms (idiopathic). however, there have been a few case reports of an association with crohn's disease, and some experts suggest a possible association with multiple sclerosis, sarcoidosis, cat scratch or lyme disease. last updated: 4/8/2012

MalaCards: Pars Planitis, also known as familial pars planitis, is related to uveitis and vasculitis. An important gene associated with Pars Planitis is CD27 (CD27 molecule), and among its related pathways are HTLV-I infection and Immune response IFN alpha/beta signaling pathway. The compounds lipoteichoic acid and gold sodium thiomalate have been mentioned in the context of this disorder. Affiliated tissues include retina and t cells.

Wikipedia:64 Intermediate uveitis is a form of uveitis localized to the vitreous and peripheral retina. Primary sites... more...

Description from OMIM:47 606177

Aliases & Classifications for Pars Planitis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 47OMIM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic
Anatomical: Eye


Aliases & Descriptions:

pars planitis 8 43 61
familial pars planitis 43 61
vitritis 43 61
peripheral retinal inflammation 43
uveitis, intermediate 61
intermediate uveitis 43
posterior cyclitis 8


External Ids:

Disease Ontology8 DOID:12731
MeSH35 D015868
ICD9CM27 363.21
NCIt40 C34903
OMIM47 606177
ICD1025 H30.2

Related Diseases for Pars Planitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Pars Planitis:



Diseases related to pars planitis

Clinical Features for Pars Planitis

Sources:
47OMIM
See all sources

Clinical features from OMIM:

606177

Drugs & Therapeutics for Pars Planitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Pars Planitis

Drug clinical trials:

Search ClinicalTrials for Pars Planitis

Search NIH Clinical Center for Pars Planitis

Search CenterWatch for Pars Planitis

Genetic Tests for Pars Planitis

Anatomical Context for Pars Planitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Pars Planitis:

33
Retina, T cells

Animal Models for Pars Planitis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Pars Planitis

Sources:
51PubMed
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Articles related to Pars Planitis:

(show top 50)    (show all 89)
idTitleAuthorsYear
1
Peripapillary choroidal neovascularization in pars planitis. (23514324)
2013
2
Clinical and epidemiological features and HLA association in patients with pars planitis]. (20537664)
2010
3
Acute zonal occult outer retinopathy (AZOOR) and pars planitis: a new association? (18369082)
2008
4
Pars planitis: a 20-year study of incidence, clinical features, and outcomes. (18724984)
2008
5
Pars planitis in children: epidemiologic, clinical, and therapeutic characteristics. (17913171)
2007
6
The enigma of pars planitis, revisited. (16564810)
2006
7
Clinical symptoms and complications of pars planitis in childhood. (15849986)
2005
8
Valsalva retinopathy: diagnostic challenges in a patient with pars-planitis. (15799745)
2005
9
Phacoemulsification with intraocular lens implantation in cases of pars planitis. (15474816)
2004
10
Elevated levels of interleukin 6 in the vitreous fluid of patients with pars planitis and posterior uveitis: the Massachusetts eye & ear experience and review of previous studies. (15385196)
2004
11
Genetic polymorphism of HLA DR in a Scottish population of patients with pars planitis. (12841565)
2003
12
Classic Pars Planitis: strong correlation of class II genes with gender and some clinical features in Mexican Mestizos. (14522094)
2003
13
An old crone finds a new home: Crohn's disease and pars planitis. (12789592)
2002
14
Peripheral retinoschisis and exudative retinal detachment in pars planitis. (12476097)
2002
15
Vitreous hemorrhage is a common complication of pediatric pars planitis. (11772586)
2002
16
Vitrectomy for pars planitis complicated by vitreous hemorrhage: visual outcome and long-term follow-up. (11292422)
2001
17
Pars planitis: epidemiology, treatment, and association with multiple sclerosis. (11449325)
2001
18
Pars planitis: a comparison of childhood onset and adult onset disease. (11341451)
2001
19
The association of HLA class II with pars planitis. (11336946)
2001
20
Coats'-like response in pars planitis. (10048380)
1999
21
Intermediate uveitis of pars planitis type in identical twins. Report of a case. (10826543)
1998
22
Familial pars planitis and dominant optic atrophy. (9134550)
1997
23
Blood serum interleukin-1 receptor antagonist in pars planitis and ocular BehAset disease. (9152064)
1997
24
Coats'-like response in a patient with pars planitis. (8795387)
1996
25
2 peripheral scatter photocoagulation for neovascularization associated with pars planitis. (7575259)
1995
26
Familial pars planitis. (7648038)
1995
27
Pars planitis in a family. (7814201)
1994
28
A fluorescein angiographic study of patients with pars planitis and peripheral exudation (snowbanking) before and after cryopexy. (8035990)
1994
29
Cataract extraction in patients with pars planitis. (8341504)
1993
30
Intermediate uveitis: what is the significance of the pars plana exudate in 'pars planitis'? A summary. (1730374)
1992
31
Ciclosporin (Sandimmun) therapy: experience in the treatment of pars planitis and present therapeutic guidelines. (1730354)
1992
32
Treatment of pars planitis with cryotherapy. (1945296)
1991
33
Cryopexy in pars planitis. (1751913)
1991
34
Lens implant surgery in pars planitis. (2402411)
1990
35
Pars planitis in father and son. (2096359)
1990
36
Clinical and immunopathological studies of pars planitis in a family. (3257703)
1988
37
The significance of the pars plana exudate in pars planitis. (3578463)
1987
38
Pars planitis and autoimmune endotheliopathy. (3565524)
1987
39
Pars planitis and autoimmune endotheliopathy. (3777084)
1986
40
Cryo therapy as an adjunct to treatment in pars planitis. (3155097)
1986
41
Pars planitis. (3467497)
1986
42
Vitreous fluorophotometry in pars planitis. (6824051)
1983
43
Pars planitis--a demyelinating disease? (7224943)
1981
44
Pars planitis. (6963826)
1981
45
Humoral and cellular immunity studies in patients with Vogt-Koyanagi-Harada syndrome and pars planitis. (7203881)
1981
46
Treatment of pars planitis. I. cryotherapy. (918841)
1977
47
Pars planitis. (269542)
1977
48
Inflammation in the region of the vitreous base. Pars planitis. (1070846)
1976
49
Origin of macular edema caused by pars planitis]. (48223)
1975
50
Mixed uveitis; pars planitis: report of a case. (1230221)
1975

Genetic Variations for Pars Planitis

Expression for genes affiliated with Pars Planitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pars Planitis

Search GEO for disease gene expression data for Pars Planitis.

Pathways for genes affiliated with Pars Planitis

Sources:
30KEGG, 54Reactome, 12EMD Millipore, 38NCBI BioSystems Database, 52QIAGEN
See all sources

Pathways related to Pars Planitis according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0HLA-B
2
Immune response IFN alpha/beta signaling pathway
Hide members
9.1HLA-A, HLA-B
39.1HLA-A, HLA-B
4
Hide members
9.1HLA-B, HLA-A
59.1HLA-B, HLA-A
6
Hide members
9.0HLA-A, HLA-DRB1
7
Hide members
9.0HLA-A, HLA-DRB1
88.5HLA-B, HLA-DRB1, HLA-A
9
Hide members
8.5HLA-B, HLA-DRB1, HLA-A
108.5HLA-A, HLA-DRB1, HLA-B
11
Hide members
8.5HLA-A, HLA-DRB1, HLA-B
12
Hide members
8.5HLA-A, HLA-DRB1, HLA-B
138.5HLA-A, HLA-DRB1, HLA-B
14
Hide members
8.0HLA-B, HLA-DRB1, HLA-A, IL1RN
15
Hide members
8.0IL1RN, HLA-A, HLA-DRB1, HLA-B

Compounds for genes affiliated with Pars Planitis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
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Compounds related to Pars Planitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1lipoteichoic acid459.5HLA-B, IL1RN
2gold sodium thiomalate459.5IL1RN, HLA-DRB1
3allergens459.3IL1RN, HLA-DRB1
4dr-10459.2HLA-A, HLA-DRB1
5ursodeoxycholic acid45 11 2411.1HLA-B, HLA-A
6cyclosporin a45 29 6010.7IL1RN, HLA-A, HLA-B
7adenylate458.5IL1RN, HLA-A, HLA-B
8tyrosine457.7HLA-B, HLA-DRB1, HLA-A, IL1RN

GO Terms for genes affiliated with Pars Planitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Pars Planitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:0426129.2HLA-A, HLA-B
2early endosome membraneGO:0319019.1HLA-A, HLA-B
3phagocytic vesicle membraneGO:0306709.0HLA-A, HLA-B
4integral to lumenal side of endoplasmic reticulum membraneGO:0715568.7HLA-A, HLA-DRB1, HLA-B
5ER to Golgi transport vesicle membraneGO:0125078.6HLA-B, HLA-DRB1, HLA-A
6Golgi membraneGO:0001398.2HLA-A, HLA-DRB1, HLA-B
7integral to plasma membraneGO:0058878.1HLA-B, HLA-DRB1, HLA-A, CD27

Biological processes related to Pars Planitis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:0024809.2HLA-B, HLA-A
2positive regulation of T cell mediated cytotoxicityGO:0019169.1HLA-A, HLA-B
3antigen processing and presentation of exogenous peptide antigen via MHC class IGO:0425909.1HLA-A, HLA-B
4type I interferon-mediated signaling pathwayGO:0603379.0HLA-B, HLA-A
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:0024798.8HLA-A, HLA-B
6detection of bacteriumGO:0160458.7HLA-A, HLA-DRB1, HLA-B
7interferon-gamma-mediated signaling pathwayGO:0603338.7HLA-A, HLA-DRB1, HLA-B
8cytokine-mediated signaling pathwayGO:0192218.6HLA-A, HLA-DRB1, HLA-B
9immune responseGO:0069558.2HLA-B, HLA-DRB1, HLA-A, IL1RN

Molecular functions related to Pars Planitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:0426058.5HLA-A, HLA-DRB1, HLA-B

Products for genes affiliated with Pars Planitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pars Planitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet