MCID: PRS012
MIFTS: 43

Pars Planitis malady

Eye diseases, Genetic diseases categories

Summaries for Pars Planitis

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Sources:
42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Pars planitis is a disease of the eye in which there is inflammation of the pars plana, a small area of tissue next to the iris that is responsible for making aqueous humor (the fluid in the eye that nourishes the lens and cornea).  pars planitis is often referred to as intermediate uveitis because the pars plana is a part of the uvea.  this condition most often affects young men and is generally not associated with any other disease or symptoms (idiopathic). however, there have been a few case reports of an association with crohn's disease, and some experts suggest a possible association with multiple sclerosis, sarcoidosis, cat scratch or lyme disease. last updated: 4/8/2012

MalaCards: Pars Planitis, also known as familial pars planitis, is related to uveitis and multiple sclerosis. An important gene associated with Pars Planitis is CD27 (CD27 molecule), and among its related pathways are HTLV-I infection and Immune response IFN alpha/beta signaling pathway. The compounds lipoteichoic acid and gold sodium thiomalate have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and t cells.

Wikipedia:63 Intermediate uveitis is a form of uveitis localized to the vitreous and peripheral retina. Primary sites... more...

Description from OMIM:46 606177

Aliases & Classifications for Pars Planitis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 46OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Eye diseases


Aliases & Descriptions:

pars planitis 8 42 60
familial pars planitis 42 60
vitritis 42 60
peripheral retinal inflammation 42
uveitis, intermediate 60
intermediate uveitis 42
posterior cyclitis 8


External Ids:

Disease Ontology8 DOID:12731
MeSH34 D015868
ICD9CM27 363.21
NCIt39 C34903
OMIM46 606177
ICD1025 H30.2

Related Diseases for Pars Planitis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Pars Planitis:



Diseases related to pars planitis

Clinical Features for Pars Planitis

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46OMIM
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Clinical features from OMIM:

606177

Drugs & Therapeutics for Pars Planitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Pars Planitis

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Genetic Tests for Pars Planitis

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Anatomical Context for Pars Planitis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Pars Planitis:

32
Eye, Retina, T cells

Animal Models for Pars Planitis or affiliated genes

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Publications for Pars Planitis

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50PubMed
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Articles related to Pars Planitis:

(show top 50)    (show all 88)
idTitleAuthorsYear
1
Association of epiretinal membranes with macular edema in pars planitis. (24332688)
2013
2
Corneal ectasia secondary to peripheral endotheliopathy in a patient with classic pars planitis. (21484170)
2011
3
Clinical and epidemiological features and HLA association in patients with pars planitis]. (20537664)
2010
4
Peptidic sequence "HSEAETGPP" is recognized by the sera of pars planitis patients. (19480736)
2009
5
Acute zonal occult outer retinopathy (AZOOR) and pars planitis: a new association? (18369082)
2008
6
Pars planitis: a 20-year study of incidence, clinical features, and outcomes. (18724984)
2008
7
Pars planitis is associated with an increased frequency of effector-memory CD57+ T cells. (17475702)
2007
8
Clinical symptoms and complications of pars planitis in childhood. (15849986)
2005
9
Valsalva retinopathy: diagnostic challenges in a patient with pars-planitis. (15799745)
2005
10
Phacoemulsification with intraocular lens implantation in cases of pars planitis. (15474816)
2004
11
Genetic polymorphism of HLA DR in a Scottish population of patients with pars planitis. (12841565)
2003
12
Pars planitis in the Mexican Mestizo population: ocular findings, treatment, and visual outcome. (12854027)
2003
13
Classic Pars Planitis: strong correlation of class II genes with gender and some clinical features in Mexican Mestizos. (14522094)
2003
14
An old crone finds a new home: Crohn's disease and pars planitis. (12789592)
2002
15
Grading of pars planitis by ultrasound biomicroscopy--echographic and clinical study. (12423740)
2002
16
Peripheral retinoschisis and exudative retinal detachment in pars planitis. (12476097)
2002
17
Vitreous hemorrhage is a common complication of pediatric pars planitis. (11772586)
2002
18
Vitrectomy for pars planitis complicated by vitreous hemorrhage: visual outcome and long-term follow-up. (11292422)
2001
19
Pars planitis: epidemiology, treatment, and association with multiple sclerosis. (11449325)
2001
20
Pars planitis: a comparison of childhood onset and adult onset disease. (11341451)
2001
21
The association of HLA class II with pars planitis. (11336946)
2001
22
Pars planitis: clinical features and class II HLA associations. (10080220)
1999
23
Coats'-like response in pars planitis. (10048380)
1999
24
Intermediate uveitis of pars planitis type in identical twins. Report of a case. (10826543)
1998
25
Familial pars planitis and dominant optic atrophy. (9134550)
1997
26
Blood serum interleukin-1 receptor antagonist in pars planitis and ocular BehAset disease. (9152064)
1997
27
Coats'-like response in a patient with pars planitis. (8795387)
1996
28
2 peripheral scatter photocoagulation for neovascularization associated with pars planitis. (7575259)
1995
29
Pars planitis in a family. (7814201)
1994
30
A fluorescein angiographic study of patients with pars planitis and peripheral exudation (snowbanking) before and after cryopexy. (8035990)
1994
31
Cataract extraction in patients with pars planitis. (8341504)
1993
32
The association of HLA-B8, B51, DR2, and multiple sclerosis in pars planitis. (8341502)
1993
33
Treatment of pars planitis with cryotherapy. (1945296)
1991
34
Cryopexy in pars planitis. (1751913)
1991
35
Lens implant surgery in pars planitis. (2402411)
1990
36
Pars planitis in father and son. (2096359)
1990
37
Pars planitis and autoimmune endotheliopathy. (3565524)
1987
38
Cryo therapy as an adjunct to treatment in pars planitis. (3155097)
1986
39
Pars planitis. (3467497)
1986
40
Pars planitis and rod-cone dystrophy. (6333906)
1983
41
Vitreous fluorophotometry in pars planitis. (6824051)
1983
42
Pars planitis--a demyelinating disease? (7224943)
1981
43
Humoral and cellular immunity studies in patients with Vogt-Koyanagi-Harada syndrome and pars planitis. (7203881)
1981
44
Pathology of pars planitis. (569977)
1978
45
Treatment of pars planitis. I. cryotherapy. (918841)
1977
46
Pars planitis. (269542)
1977
47
Inflammation in the region of the vitreous base. Pars planitis. (1070846)
1976
48
Origin of macular edema caused by pars planitis]. (48223)
1975
49
Mixed uveitis; pars planitis: report of a case. (1230221)
1975
50
Iridocyclitis with hemorrhagic pars planitis due to Microfilaria bancrofti. (4675032)
1972

Genetic Variations for Pars Planitis

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Expression for genes affiliated with Pars Planitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pars Planitis

Search GEO for disease gene expression data for Pars Planitis.

Pathways for genes affiliated with Pars Planitis

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Sources:
29KEGG, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN
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Pathways related to Pars Planitis according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0HLA-B
2
Immune response IFN alpha/beta signaling pathway
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9.1HLA-A, HLA-B
39.1HLA-A, HLA-B
4
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9.1HLA-B, HLA-A
59.1HLA-B, HLA-A
6
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9.0HLA-A, HLA-DRB1
7
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9.0HLA-A, HLA-DRB1
88.5HLA-B, HLA-DRB1, HLA-A
9
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8.5HLA-B, HLA-DRB1, HLA-A
108.5HLA-A, HLA-DRB1, HLA-B
11
Hide members
8.5HLA-A, HLA-DRB1, HLA-B
12
Hide members
8.5HLA-A, HLA-DRB1, HLA-B
138.5HLA-A, HLA-DRB1, HLA-B
14
Hide members
8.0HLA-B, HLA-DRB1, HLA-A, IL1RN
15
Hide members
8.0IL1RN, HLA-A, HLA-DRB1, HLA-B

Compounds for genes affiliated with Pars Planitis

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Pars Planitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1lipoteichoic acid449.5HLA-B, IL1RN
2gold sodium thiomalate449.5IL1RN, HLA-DRB1
3allergens449.3IL1RN, HLA-DRB1
4dr-10449.2HLA-A, HLA-DRB1
5ursodeoxycholic acid44 11 2411.1HLA-B, HLA-A
6cyclosporin a44 28 5910.7IL1RN, HLA-A, HLA-B
7adenylate448.5IL1RN, HLA-A, HLA-B
8tyrosine447.7HLA-B, HLA-DRB1, HLA-A, IL1RN

GO Terms for genes affiliated with Pars Planitis

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16Gene Ontology
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Cellular components related to Pars Planitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:0426129.2HLA-A, HLA-B
2early endosome membraneGO:0319019.1HLA-A, HLA-B
3phagocytic vesicle membraneGO:0306709.0HLA-A, HLA-B
4integral to lumenal side of endoplasmic reticulum membraneGO:0715568.7HLA-A, HLA-DRB1, HLA-B
5ER to Golgi transport vesicle membraneGO:0125078.6HLA-B, HLA-DRB1, HLA-A
6Golgi membraneGO:0001398.2HLA-A, HLA-DRB1, HLA-B
7integral to plasma membraneGO:0058878.1HLA-B, HLA-DRB1, HLA-A, CD27

Biological processes related to Pars Planitis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:0024809.2HLA-B, HLA-A
2positive regulation of T cell mediated cytotoxicityGO:0019169.1HLA-A, HLA-B
3antigen processing and presentation of exogenous peptide antigen via MHC class IGO:0425909.1HLA-A, HLA-B
4type I interferon-mediated signaling pathwayGO:0603379.0HLA-B, HLA-A
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:0024798.8HLA-A, HLA-B
6detection of bacteriumGO:0160458.7HLA-A, HLA-DRB1, HLA-B
7interferon-gamma-mediated signaling pathwayGO:0603338.7HLA-A, HLA-DRB1, HLA-B
8cytokine-mediated signaling pathwayGO:0192218.6HLA-A, HLA-DRB1, HLA-B
9immune responseGO:0069558.2HLA-B, HLA-DRB1, HLA-A, IL1RN

Molecular functions related to Pars Planitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:0426058.5HLA-A, HLA-DRB1, HLA-B

Products for genes affiliated with Pars Planitis

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Sources for Pars Planitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet