MCID: PRT001
MIFTS: 23

Partial Fetal Alcohol Syndrome malady

Summaries for Partial Fetal Alcohol Syndrome

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A fetal alcohol spectrum disorder that results in most, but not all, of the growth deficiency and/or craniofacial features of fetal alcohol syndrome including central nervous system dysfunction due to prenatal alcohol exposure.

MalaCards: Partial Fetal Alcohol Syndrome is related to fetal alcohol syndrome and fetal alcohol spectrum disorder. An important gene associated with Partial Fetal Alcohol Syndrome is PFAS (phosphoribosylformylglycinamidine synthase), and among its related pathways are Canonical Wnt signaling pathway and Neural Crest Differentiation. The compound acetaldehyde have been mentioned in the context of this disorder. Related mouse phenotypes are embryogenesis and homeostasis/metabolism.

Aliases & Classifications for Partial Fetal Alcohol Syndrome

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8Disease Ontology, 10DISEASES
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Aliases & Descriptions:

partial fetal alcohol syndrome 8 10


External Ids:

Disease Ontology8 DOID:0050666

Related Diseases for Partial Fetal Alcohol Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Partial Fetal Alcohol Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1fetal alcohol syndrome10.3
2fetal alcohol spectrum disorder10.0PFAS
3alcohol-related neurodevelopmental disorder10.0PFAS
4coloboma10.0OTX2
5holoprosencephaly10.0ZIC5

Graphical network of diseases related to Partial Fetal Alcohol Syndrome:



Diseases related to partial fetal alcohol syndrome

Clinical Features for Partial Fetal Alcohol Syndrome

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Drugs & Therapeutics for Partial Fetal Alcohol Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Partial Fetal Alcohol Syndrome

Drug clinical trials:

Search ClinicalTrials for Partial Fetal Alcohol Syndrome

Search NIH Clinical Center for Partial Fetal Alcohol Syndrome

Search CenterWatch for Partial Fetal Alcohol Syndrome

Genetic Tests for Partial Fetal Alcohol Syndrome

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Anatomical Context for Partial Fetal Alcohol Syndrome

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Animal Models for Partial Fetal Alcohol Syndrome or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Partial Fetal Alcohol Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.7ZIC5, DVL3, OTX2, EN2, ALDH1A2
2MP:00053768.1ALDH1A2, EN2, OTX2, DVL3, DMBX1, DIO3
3MP:00053828.1ALDH1A2, ZIC5, NKD2, PFAS, DVL3, OTX2
4MP:00053908.0ZIC5, NKD2, PFAS, DVL3, OTX2, ALDH1A2
5MP:00053897.9DIO3, DMBX1, NKD2, OTX2, EN2
6MP:00036317.8ZIC5, DMBX1, DVL3, OTX2, EN2, ALDH1A2
7MP:00107687.6ZIC5, DIO3, DMBX1, DVL3, OTX2, EN2
8MP:00053787.0ZIC5, DIO3, DMBX1, NKD2, DVL3, OTX2

Publications for Partial Fetal Alcohol Syndrome

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50PubMed
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Articles related to Partial Fetal Alcohol Syndrome:

idTitleAuthorsYear
1
Maternal risk factors predicting child physical characteristics and dysmorphology in fetal alcohol syndrome and partial fetal alcohol syndrome. (21658862)
2011
2
Maternal risk factors for fetal alcohol syndrome and partial fetal alcohol syndrome in South Africa: a third study. (18336634)
2008
3
The epidemiology of fetal alcohol syndrome and partial FAS in a South African community. (17127017)
2007
4
Increased cell death and reduced neural crest cell numbers in ethanol-exposed embryos: partial basis for the fetal alcohol syndrome phenotype. (7625573)
1995
5
Stage-dependent effects of ethanol on cranial neural crest cell development: partial basis for the phenotypic variations observed in fetal alcohol syndrome. (8749810)
1995

Genetic Variations for Partial Fetal Alcohol Syndrome

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Expression for genes affiliated with Partial Fetal Alcohol Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Partial Fetal Alcohol Syndrome

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Pathways for genes affiliated with Partial Fetal Alcohol Syndrome

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Sources:
37NCBI BioSystems Database, 4Cell Signaling Technology
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Pathways related to Partial Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3DVL3, NKD2
29.1DVL3, DMBX1, ZIC5
39.0OTX2, DVL3, NKD2

Compounds for genes affiliated with Partial Fetal Alcohol Syndrome

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44Novoseek, 28IUPHAR, 24HMDB
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Compounds related to Partial Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1acetaldehyde44 28 2411.6ADH6, ALDH1A2

GO Terms for genes affiliated with Partial Fetal Alcohol Syndrome

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Sources:
16Gene Ontology
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Biological processes related to Partial Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hindbrain developmentGO:0309029.7ALDH1A2, EN2
2forebrain developmentGO:0309009.7OTX2, ZIC5
3midbrain developmentGO:0309019.5EN2, OTX2

Molecular functions related to Partial Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:0435659.2DMBX1, EN2, OTX2
2protein heterodimerization activityGO:0469828.9DVL3, OTX2, DMBX1
3sequence-specific DNA binding transcription factor activityGO:0037008.7EN2, OTX2, DMBX1, ZIC5

Products for genes affiliated with Partial Fetal Alcohol Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Partial Fetal Alcohol Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet