MCID: PRT001
MIFTS: 20

Partial Fetal Alcohol Syndrome malady

Categories: Mental diseases, Fetal diseases

Aliases & Classifications for Partial Fetal Alcohol Syndrome

Aliases & Descriptions for Partial Fetal Alcohol Syndrome:

Name: Partial Fetal Alcohol Syndrome 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050666

Summaries for Partial Fetal Alcohol Syndrome

Disease Ontology : 12 A fetal alcohol spectrum disorder that results in most, but not all, of the growth deficiency and/or craniofacial features of fetal alcohol syndrome including central nervous system dysfunction due to prenatal alcohol exposure.

MalaCards based summary : Partial Fetal Alcohol Syndrome is related to fetal alcohol spectrum disorder and postauricular lymphadenitis. An important gene associated with Partial Fetal Alcohol Syndrome is PFAS (Phosphoribosylformylglycinamidine Synthase). The drugs Ethanol and Glycerol have been mentioned in the context of this disorder. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and growth/size/body region

Related Diseases for Partial Fetal Alcohol Syndrome

Diseases related to Partial Fetal Alcohol Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 fetal alcohol spectrum disorder 11.0
2 postauricular lymphadenitis 10.0 EP300 RTN4
3 fetal alcohol syndrome 9.9
4 spastic cerebral palsy 8.4 ACER3 EP300 FASN FEZF2 GMDS NEUROD2

Symptoms & Phenotypes for Partial Fetal Alcohol Syndrome

GenomeRNAi Phenotypes related to Partial Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.55 PFAS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.55 PFAS EP300
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.55 PFAS
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.55 GMDS EP300
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.55 GMDS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.55 GMDS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.55 GMDS
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.55 PFAS
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-195 9.55 PFAS EP300
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.55 EP300
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.55 GMDS
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.55 GMDS PFAS EP300

MGI Mouse Phenotypes related to Partial Fetal Alcohol Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.7 EP300 FASN FEZF2 NEUROD2 NEUROG2 NOVA1
2 mortality/aging MP:0010768 9.56 EP300 FASN FEZF2 NEUROD2 NEUROG2 NOVA1
3 nervous system MP:0003631 9.17 RTN4 EP300 FASN FEZF2 NEUROD2 NEUROG2

Drugs & Therapeutics for Partial Fetal Alcohol Syndrome

Drugs for Partial Fetal Alcohol Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 2,Phase 1 64-17-5 702
2
Glycerol Approved, Experimental Phase 2 56-81-5 753
3
Choline Approved, Nutraceutical Phase 2,Phase 1 62-49-7 305
4 Anti-Infective Agents Phase 2,Phase 1
5 Anti-Infective Agents, Local Phase 2,Phase 1
6 Antimetabolites Phase 2,Phase 1
7 Central Nervous System Depressants Phase 2,Phase 1
8 Gastrointestinal Agents Phase 2,Phase 1
9 Hypolipidemic Agents Phase 2,Phase 1
10 Lipid Regulating Agents Phase 2,Phase 1
11 Nootropic Agents Phase 2,Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Choline Supplementation in Children With Fetal Alcohol Spectrum Disorders Completed NCT01911299 Phase 2
2 Postnatal Choline Supplementation in Children With Prenatal Alcohol Exposure Completed NCT01149538 Phase 1, Phase 2
3 Parenting Training for Children With FASD Recruiting NCT02210455

Search NIH Clinical Center for Partial Fetal Alcohol Syndrome

Genetic Tests for Partial Fetal Alcohol Syndrome

Anatomical Context for Partial Fetal Alcohol Syndrome

Publications for Partial Fetal Alcohol Syndrome

Articles related to Partial Fetal Alcohol Syndrome:

id Title Authors Year
1
Prevalence and characteristics of fetal alcohol syndrome and partial fetal alcohol syndrome in a Rocky Mountain Region City. ( 26321671 )
2015
2
Maternal risk factors predicting child physical characteristics and dysmorphology in fetal alcohol syndrome and partial fetal alcohol syndrome. ( 21658862 )
2011
3
Maternal risk factors for fetal alcohol syndrome and partial fetal alcohol syndrome in South Africa: a third study. ( 18336634 )
2008

Variations for Partial Fetal Alcohol Syndrome

Expression for Partial Fetal Alcohol Syndrome

Search GEO for disease gene expression data for Partial Fetal Alcohol Syndrome.

Pathways for Partial Fetal Alcohol Syndrome

GO Terms for Partial Fetal Alcohol Syndrome

Biological processes related to Partial Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 axonal fasciculation GO:0007413 9.16 FEZF2 RTN4
2 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.13 EP300 NEUROD2 NEUROG2
3 nervous system development GO:0007399 9.02 EP300 FEZF2 NEUROD2 NEUROG2 RTN4

Molecular functions related to Partial Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 E-box binding GO:0070888 8.96 NEUROD2 NEUROG2
2 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0001228 8.8 EP300 FEZF2 NEUROD2

Sources for Partial Fetal Alcohol Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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