MCID: PRT001
MIFTS: 22

Partial Fetal Alcohol Syndrome

Categories: Fetal diseases, Mental diseases

Aliases & Classifications for Partial Fetal Alcohol Syndrome

MalaCards integrated aliases for Partial Fetal Alcohol Syndrome:

Name: Partial Fetal Alcohol Syndrome 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050666
UMLS 69 C3661483

Summaries for Partial Fetal Alcohol Syndrome

Disease Ontology : 12 A fetal alcohol spectrum disorder that results in most, but not all, of the growth deficiency and/or craniofacial features of fetal alcohol syndrome including central nervous system dysfunction due to prenatal alcohol exposure.

MalaCards based summary : Partial Fetal Alcohol Syndrome is related to fetal alcohol syndrome and fetal alcohol spectrum disorder. An important gene associated with Partial Fetal Alcohol Syndrome is PFAS (Phosphoribosylformylglycinamidine Synthase). The drugs Ethanol and Choline have been mentioned in the context of this disorder. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Partial Fetal Alcohol Syndrome

Diseases related to Partial Fetal Alcohol Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 fetal alcohol syndrome 11.4
2 fetal alcohol spectrum disorder 11.1
3 ideomotor apraxia 9.8 EP300 RTN4
4 disease of mental health 9.6 EP300 RTN4

Symptoms & Phenotypes for Partial Fetal Alcohol Syndrome

GenomeRNAi Phenotypes related to Partial Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

25 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.55 PFAS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.55 EP300 PFAS
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.55 PFAS
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.55 EP300 GMDS
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.55 GMDS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.55 GMDS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.55 GMDS
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.55 PFAS
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-195 9.55 EP300 PFAS
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.55 EP300
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.55 GMDS
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.55 EP300 GMDS PFAS

MGI Mouse Phenotypes related to Partial Fetal Alcohol Syndrome:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.7 EP300 FASN FEZF2 NEUROD2 NEUROG2 NOVA1
2 mortality/aging MP:0010768 9.56 EP300 FASN FEZF2 NEUROD2 NEUROG2 NOVA1
3 nervous system MP:0003631 9.17 EP300 FASN FEZF2 NEUROD2 NEUROG2 NOVA1

Drugs & Therapeutics for Partial Fetal Alcohol Syndrome

Drugs for Partial Fetal Alcohol Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 2,Phase 1 64-17-5 702
2
Choline Approved, Nutraceutical Phase 2,Phase 1 62-49-7 305
3 Anti-Infective Agents Phase 2,Phase 1
4 Anti-Infective Agents, Local Phase 2,Phase 1
5 Central Nervous System Depressants Phase 2,Phase 1
6 Antimetabolites Phase 2,Phase 1
7 Gastrointestinal Agents Phase 2,Phase 1
8 Hypolipidemic Agents Phase 2,Phase 1
9 Lipid Regulating Agents Phase 2,Phase 1
10 Nootropic Agents Phase 2,Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Choline Supplementation in Children With Fetal Alcohol Spectrum Disorders Completed NCT01911299 Phase 2
2 Postnatal Choline Supplementation in Children With Prenatal Alcohol Exposure Completed NCT01149538 Phase 1, Phase 2 Choline bitartrate
3 Parenting Training for Children With FASD Unknown status NCT02210455

Search NIH Clinical Center for Partial Fetal Alcohol Syndrome

Genetic Tests for Partial Fetal Alcohol Syndrome

Anatomical Context for Partial Fetal Alcohol Syndrome

Publications for Partial Fetal Alcohol Syndrome

Articles related to Partial Fetal Alcohol Syndrome:

# Title Authors Year
1
Prevalence and characteristics of fetal alcohol syndrome and partial fetal alcohol syndrome in a Rocky Mountain Region City. ( 26321671 )
2015
2
Maternal risk factors predicting child physical characteristics and dysmorphology in fetal alcohol syndrome and partial fetal alcohol syndrome. ( 21658862 )
2011
3
Maternal risk factors for fetal alcohol syndrome and partial fetal alcohol syndrome in South Africa: a third study. ( 18336634 )
2008

Variations for Partial Fetal Alcohol Syndrome

Expression for Partial Fetal Alcohol Syndrome

Search GEO for disease gene expression data for Partial Fetal Alcohol Syndrome.

Pathways for Partial Fetal Alcohol Syndrome

GO Terms for Partial Fetal Alcohol Syndrome

Biological processes related to Partial Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA binding transcription factor activity GO:0051091 9.13 EP300 NEUROD2 NEUROG2
2 nervous system development GO:0007399 9.02 EP300 FEZF2 NEUROD2 NEUROG2 RTN4

Molecular functions related to Partial Fetal Alcohol Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 E-box binding GO:0070888 8.62 NEUROD2 NEUROG2

Sources for Partial Fetal Alcohol Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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