MCID: PTN002
MIFTS: 48

Patent Ductus Arteriosus

Categories: Rare diseases, Cardiovascular diseases, Genetic diseases

Aliases & Classifications for Patent Ductus Arteriosus

MalaCards integrated aliases for Patent Ductus Arteriosus:

Name: Patent Ductus Arteriosus 12 50 13 14
Ductus Arteriosus, Patent 12 42
Patent Ductus Arteriosus - Persisting Type 69
Patent Ductus Arteriosus Familial 50
Patency of the Ductus Arteriosus 50
Ductus Arteriosus Patent 52
Patent Ductus Botalli 12
Pda1 50
Pda 50

Classifications:



External Ids:

Disease Ontology 12 DOID:13832
ICD10 33 Q25.0
ICD9CM 35 747.0
MeSH 42 D004374
NCIt 47 C84492
SNOMED-CT 64 156928009 83330001
UMLS 69 C0013274

Summaries for Patent Ductus Arteriosus

MalaCards based summary : Patent Ductus Arteriosus, also known as ductus arteriosus, patent, is related to patent ductus arteriosus 2 and patent ductus arteriosus 3. An important gene associated with Patent Ductus Arteriosus is PRDM6 (PR/SET Domain 6), and among its related pathways/superpathways are Inwardly rectifying K+ channels and Prostaglandin Synthesis and Regulation. The drugs Acetaminophen and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and lung, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 72 Patent ductus arteriosus (PDA) is a condition wherein the ductus arteriosus fails to close after... more...

Related Diseases for Patent Ductus Arteriosus

Diseases in the Patent Ductus Arteriosus family:

Patent Ductus Arteriosus 3 Patent Ductus Arteriosus 2

Diseases related to Patent Ductus Arteriosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)
id Related Disease Score Top Affiliating Genes
1 patent ductus arteriosus 2 34.1 TBX5 TFAP2B TGFBR2
2 patent ductus arteriosus 3 12.5
3 char syndrome 12.2
4 patent ductus arteriosus and bicuspid aortic valve with hand anomalies 12.2
5 pulmonary artery coming from patent ductus arteriosus 12.2
6 intestinal pseudoobstruction with patent ductus arteriosus and natal teeth 12.2
7 congenital patent ductus arteriosus aneurysm 12.2
8 multisystemic smooth muscle dysfunction syndrome 11.4
9 gorlin-chaudhry-moss syndrome 11.3
10 aortic aneurysm, familial thoracic 4 11.3
11 heterotaxy, visceral, 1, x-linked 11.3
12 hypertrichotic osteochondrodysplasia 11.3
13 premature closure of the arterial duct 11.2
14 natal teeth, intestinal pseudoobstruction and patent ductus 11.2
15 axenfeld-rieger syndrome, type 3 11.1
16 hypertelorism, teebi type 11.1
17 hypoplastic left heart syndrome 11.1
18 nephronophthisis 16 11.1
19 femoral-facial syndrome 11.1
20 nephronophthisis 20 11.1
21 congenital heart defects, multiple types, 4 11.1
22 pancreatic agenesis and congenital heart defects 11.1
23 manouvrier syndrome 11.1
24 cranioosteoarthropathy 11.1
25 heterotopia, periventricular 11.1
26 autosomal recessive spastic paraplegia type 59 10.8 PRDM6 TFAP2B
27 sed congenita 10.6 ABCC9 KCNJ8
28 ventricular septal defect 10.6
29 atrial fibrillation, familial, 12 10.6 ABCC9 KCNJ8
30 aneurysm 10.5
31 right aortic arch 10.5
32 ciliary discoordination, due to random ciliary orientation 10.5 EDN1 NPPB
33 pulmonary hypertension 10.5
34 aortic coarctation 10.4
35 endocarditis 10.4
36 noonan syndrome 2 10.4 ABCC9 KCNJ8 MYH11
37 cerebritis 10.4
38 fetal alcohol syndrome 10.4 EDN1 GATA6 TBX5
39 indeterminate leprosy 10.4 ABCC9 EDN1
40 granulomatous myositis 10.3 MYH11 TGFBR2
41 malignant pineal area germ cell neoplasm 10.3 GATA6 NPPB TBX5
42 thrombocytopenia with or without dyserythropoietic anemia 10.3 MYH11 TGFBR2
43 eisenmenger syndrome 10.3
44 bronchopulmonary dysplasia 10.3
45 thrombocytopenia 10.3
46 heart disease 10.3
47 pulmonic stenosis 10.3
48 subacute bacterial endocarditis 10.3
49 elizabethkingia anophelis infection 10.2 EDN1 TGFBR2
50 cervical serous adenocarcinoma 10.2 GATA6 TBX5

Graphical network of the top 20 diseases related to Patent Ductus Arteriosus:



Diseases related to Patent Ductus Arteriosus

Symptoms & Phenotypes for Patent Ductus Arteriosus

MGI Mouse Phenotypes related to Patent Ductus Arteriosus:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.21 ABCC9 CHD7 EDN1 GATA6 HPGD KCNJ8
2 homeostasis/metabolism MP:0005376 10.16 LCN2 MYH11 PRDM6 PTGER4 PTGS2 SFTPB
3 mortality/aging MP:0010768 10.09 PRDM6 PTGER4 PTGS2 SFTPB TBX5 TFAP2B
4 cellular MP:0005384 10.06 LCN2 MATR3 MYH11 PTGER4 PTGS2 TFAP2B
5 muscle MP:0005369 9.61 ABCC9 CHD7 EDN1 GATA6 MYH11 PTGS2
6 respiratory system MP:0005388 9.28 CHD7 GATA6 MYH11 PRDM6 PTGER4 PTGS2

Drugs & Therapeutics for Patent Ductus Arteriosus

Drugs for Patent Ductus Arteriosus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 116)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4,Phase 2,Phase 3,Phase 1 103-90-2 1983
2
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1 15687-27-1 3672
3
Indomethacin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53-86-1 3715
4 Poractant alfa Approved Phase 4,Phase 3 129069-19-8
5 Beractant Approved Phase 4 108778-82-1
6
Iodine Investigational Phase 4 7553-56-2 807
7 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
8 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
9 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
10 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1
11 Antipyretics Phase 4,Phase 2,Phase 3,Phase 1
12 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
13 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
14 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
15 Pulmonary Surfactants Phase 4,Phase 3,Phase 2
16 Tocolytic Agents Phase 4,Phase 3,Phase 2
17 Respiratory System Agents Phase 4,Phase 3,Phase 2
18 Anti-Infective Agents Phase 4
19 Anti-Infective Agents, Local Phase 4
20 cadexomer iodine Phase 4
21 Micronutrients Phase 4
22 Trace Elements Phase 4
23
Benzocaine Approved Phase 2, Phase 3 1994-09-7, 94-09-7 2337
24
Dexmedetomidine Approved, Vet_approved Phase 3 76631-46-4, 113775-47-6 68602 5311068 56032
25
Dopamine Approved Phase 2, Phase 3 51-61-6, 62-31-7 681
26
Betamethasone Approved, Vet_approved Phase 3 378-44-9 9782
27
Fenoldopam Approved Phase 2, Phase 3 67227-56-9, 67227-57-0 3341
28 tannic acid Approved, Nutraceutical Phase 2, Phase 3
29
Caffeine Approved, Nutraceutical Phase 3 58-08-2 2519
30 Pharmaceutical Solutions Phase 3,Phase 1,Phase 2
31 Antioxidants Phase 3,Phase 2
32 Protective Agents Phase 3,Phase 2
33 Phosphodiesterase Inhibitors Phase 3,Phase 2
34 Vasodilator Agents Phase 2, Phase 3
35 Adrenergic Agents Phase 3
36 Adrenergic Agonists Phase 3
37 Adrenergic alpha-2 Receptor Agonists Phase 3
38 Adrenergic alpha-Agonists Phase 3
39 Central Nervous System Depressants Phase 3
40 Hypnotics and Sedatives Phase 3
41 Neurotransmitter Agents Phase 3,Phase 2
42
Bilirubin Phase 3 635-65-4 5280352
43 Anti-Asthmatic Agents Phase 3,Phase 2
44 Hormone Antagonists Phase 3,Phase 2
45 Hormones Phase 3,Phase 2
46 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
47 Dopamine Agents Phase 2, Phase 3
48 Betamethasone benzoate Phase 3
49 Betamethasone sodium phosphate Phase 3
50 Betamethasone Valerate Phase 3 2152-44-5

Interventional clinical trials:

(show top 50) (show all 141)

id Name Status NCT ID Phase Drugs
1 Serum Level Measurement of Oral Paracetamol and Oral Ibuprofen for Patent Ductus Arteriosus Treatment in Preterm Infants Unknown status NCT01544972 Phase 4 Oral paracetamol;Oral ibuprofen
2 Early CPAP in Respiratory Distress Syndrome Unknown status NCT00368680 Phase 4
3 Cpap at Delivery Room for Preterm Infants Unknown status NCT01024361 Phase 4
4 Influence of Treatment for Patent Ductus Arteriosus on Cerebral Oxygenation in Preterm Infants Completed NCT01428180 Phase 4 Indomethacin;Ibuprofen
5 Comparative Study of Efficacy and Safety of Oral Ibuprofen and Intravenous Ibuprofen in Closure of Patent Ductus Arteriosus in Very Low Birth Weight Infants Completed NCT00642330 Phase 4 oral ibuprofen;intravenous ibuprofen
6 Oral Paracetamol Versus Oral Ibuprofen in Management of Patent Ductus Arteriosus in Preterm Infants: A Randomised Controlled Trial Completed NCT01536158 Phase 4 Oral paracetamol;Oral ibuprofen
7 Ibuprofen and Renal Function in Premature Infants Completed NCT00217191 Phase 4 Ibuprofen
8 A Randomised Controlled Trial of Iodide Supplementation in Preterm Infants Follow-up at 2 Years Completed NCT00638092 Phase 4 sodium iodide;Sodium Chloride
9 OPTIMIST-A Trial: Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on CPAP Recruiting NCT02140580 Phase 4
10 Paracetamol Versus Ibuprofen for PDA Closure Active, not recruiting NCT03265782 Phase 4 ibuprofen;paracetamol
11 Safety/Efficacy Study of Optimizing Ibuprofen Dosing to Achieve Higher PDA Closure Rates Terminated NCT00961753 Phase 4 optimized ibuprofen;Standard Ibuprofen
12 Curosurf and Survanta Treatment(CAST)of RDS in Very Premature Infants Terminated NCT00767039 Phase 4 Survanta (beractant);Curosurf (poractant)
13 Comparing Ibuprofen And Indomethacin For The Treatment Of The Patent Ductus Arteriosus in Very Premature Babies Withdrawn NCT00470743 Phase 4 Ibuprofen;Indomethacin
14 Echocardiographically Guided Versus Standard Ibuprofen Treatment for Patent Ductus Arteriosus Completed NCT01593163 Phase 3 Ibuprofen EchoG;Standard ibuprofen treatment
15 High-dose Ibuprofen for Patent Ductus Arteriosus (PDA) in Preterm Infant Completed NCT01243996 Phase 2, Phase 3 Ibuprofen
16 Safety and Efficacy Study of Ibuprofen l-Lysine Solution in Premature Infants for Treatment of PDA Completed NCT00440804 Phase 3 ibuprofen l-lysine iv solution (NeoProfen (R) )
17 Ibuprofen vs. Continuous Indomethacin in the Treatment of PDA Completed NCT00485160 Phase 3 Continuous indomethacin;ibuprofen
18 Management of Patent Ductus in Premature Infants Completed NCT00000494 Phase 3 indomethacin
19 Trial of Indomethacin Prophylaxis in Preterm Infants (TIPP) Completed NCT00009646 Phase 3 indomethacin;Indomethacin;Placebo
20 The Pharmacology and Hemodynamics of Dexmedetomidine in Children With Congenital Heart Disease Completed NCT00480740 Phase 3 Dexmedetomidine
21 NIV Strategies for RDS in Preterm Infants. NIV (Non Invasive Ventilation), RDS (Respiratory Distress Syndrome) Completed NCT02259400 Phase 2, Phase 3
22 Canadian Oxygen Trial (COT) Completed NCT00637169 Phase 3
23 Trial of Aggressive Versus Conservative Phototherapy in Infants <1,000 Grams Birth Weight Completed NCT00114543 Phase 3
24 Adding Paracetamol to Ibuprofen for Treatment of Patent Ductus Arteriosus in Preterm Infants Recruiting NCT02002741 Phase 2, Phase 3 Paracetamol;Placebo
25 Platelet Transfusion for Treatment of Patent Ductus Arteriosus in Thrombocytopenic Preterm Neonates Recruiting NCT03022253 Phase 3 Paracetamol;Ibuprofen
26 Paracetamol vs Ibuprofen for PDA Closure in Preterm Infants. Recruiting NCT02056223 Phase 2, Phase 3 Intravenous paracetamol;Intravenous ibuprofen
27 Paracetamol (Acetaminophen) for Closure of PDA in Preterm Infants Recruiting NCT01755728 Phase 3 Paracetamol;Ibuprofen
28 Dose Reduction of Antenatal Betamethasone Given to Prevent the Neonatal Complications Associated With Very Preterm Birth Recruiting NCT02897076 Phase 3 betamethasone 24 mg;12mg betamethasone +placebo
29 Comparison of Two Flow Rates of HHHFNC to Prevent Extubation Failure in Preterm Infants Recruiting NCT02681315 Phase 3
30 Early Ibuprofen Treatment of Patent Ductus Arteriosus (PDA) in Premature Infants (TRIOCAPI) Active, not recruiting NCT01630278 Phase 3 Ibuprofen;Placebo
31 L-Thyroxine Supplementation for Preterm Newborns Less Than 32 Weeks of Gestation With Hypothyroxinemia Active, not recruiting NCT01306227 Phase 3 L-Thyroxine;water
32 Fenoldopam to Prevent Renal Dysfunction in Indomethacin Treated Preterm Infants Not yet recruiting NCT02620761 Phase 2, Phase 3 Fenoldopam;0.9%NS
33 An Escalating Dose Indomethacin for the Treatment of Persistent Patent Ductus Arteriosus (PDA) In Preterm Infants Terminated NCT00750581 Phase 2, Phase 3 Indomethacin
34 Surfactant Versus Nasal Continuous Positive Airway Pressure (nCPAP) for Respiratory Distress Syndrome in the Newborn ≥ 35 Weeks of Gestation Terminated NCT01306240 Phase 3
35 Treating the Resistant Patent Ductus Arteriosus (PDA) Unknown status NCT00616382 Phase 2 Indomethacin;Pentoxifylline
36 Paracetamol and Patent Ductus Arteriosus (PDA) Unknown status NCT01291654 Phase 2 Paracetamol;NSAID;D5W
37 Comparison of Oral and Intravenous Ibuprofen for PDA Treatment in Premature Infants Unknown status NCT01149564 Phase 1, Phase 2 iv ibuprofen;oral ibuprofen
38 Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants Unknown status NCT00910234 Phase 1, Phase 2 recombinant human erythropoietin (rhEpo);recombinant human erythropoietin (rhEpo);Normal saline
39 Indomethacin Versus Placebo in Women With Preterm Premature Rupture of Membranes (PPROM) Unknown status NCT00466128 Phase 2 indomethacin
40 Comparison of 2 Different Indomethacin Dosing Protocols to Treat Infants Delivered at <28 Weeks Gestation With a Persistent Patent Ductus Arteriosus Completed NCT00187447 Phase 2 indomethacin (two different dosing regimens)
41 Safety and Effectiveness of the Device "Nit-Occlud® PDA-R" Completed NCT01063712 Phase 2
42 The Preterm Infants' Paracetamol Study Completed NCT01938261 Phase 2 paracetamol;0.45 % saline solution
43 Ventilatory Management of the Preterm Neonate in the Delivery Room Completed NCT01255826 Phase 2
44 The Best Treatment Strategy: Surgical vs Pharmacological to Close the Ductus Arteriosus Persistent in Preterm Infants Recruiting NCT02602054 Phase 2 Control group
45 Paracetamol in Patent Ductus Arteriosus Recruiting NCT02422966 Phase 2 Paracetamol;Ibuprofen
46 Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus Recruiting NCT01958320 Phase 2
47 Chest Shielding in Premature Infants During Phototherapy Recruiting NCT02552927 Phase 2
48 No Treatment Versus Oral Ibuprofen Treatment for Patent Ductus Arteriosus in Preterm Infants Recruiting NCT02128191 Phase 2 Oral ibuprofen;Normal saline
49 Impact of the Administration of Fludrocortisone in Very Premature Infants Recruiting NCT03001089 Phase 2 Oral Fludrocortisone (enteral);Placebo Oral Tablet
50 Paracetamol Treatment of the Borderline Significant PDA Active, not recruiting NCT02819414 Phase 2 Paracetamol drops

Search NIH Clinical Center for Patent Ductus Arteriosus

Cochrane evidence based reviews: ductus arteriosus, patent

Genetic Tests for Patent Ductus Arteriosus

Anatomical Context for Patent Ductus Arteriosus

MalaCards organs/tissues related to Patent Ductus Arteriosus:

39
Heart, Brain, Lung, Kidney, Bone, Testes, Smooth Muscle

Publications for Patent Ductus Arteriosus

Articles related to Patent Ductus Arteriosus:

(show top 50) (show all 742)
id Title Authors Year
1
Infections following surgical patent ductus arteriosus ligation in VLBW neonates. ( 28757329 )
2017
2
Lung function in very low birth weight infants after pharmacological and surgical treatment of patent ductus arteriosus - a retrospective analysis. ( 28056907 )
2017
3
Comparative study of the efficacy and safety of paracetamol, ibuprofen, and indomethacin in closure of patent ductus arteriosus in preterm neonates. ( 28004188 )
2017
4
Initial experience with the 3.3 Fr Mongoose(Ar) pigtail catheter for aortic angiography during patent ductus arteriosus closure in small patients. ( 28928609 )
2017
5
Heart rate and blood pressure variations after transvascular patent ductus arteriosus occlusion in dogs. ( 28898782 )
2017
6
Transcatheter Occlusion of Patent Ductus Arteriosus in Preterm Infants Weighing Less Than 2 kg With the Amplatzer Duct Occluder II Additional Sizes Device. ( 28916428 )
2017
7
An experimental canine patent ductus arteriosus occlusion device based on shape memory polymer foam in a nitinol cage. ( 28759840 )
2017
8
Sizing of patent ductus arteriosus in adults for transcatheter closure using the balloon pull-through technique. ( 28944572 )
2017
9
Minimally invasive thoracoscopic closure versus thoracotomy in children with patent ductus arteriosus. ( 27993195 )
2017
10
Efficacy and Safety of Rectal Ibuprofen for Patent Ductus Arteriosus Closure in Very Low Birth Weight Preterm Infants. ( 28052714 )
2017
11
Simultaneous transcatheter therapy for perimembranous ventricular septal defect combined with patent ductus arteriosus. ( 28497553 )
2017
12
Neurodevelopmental Outcome in Relation to Treatment of Patent Ductus Arteriosus-Reply. ( 28846753 )
2017
13
Urinary NT-proBNP levels and echocardiographic parameters for patent ductus arteriosus. ( 28906496 )
2017
14
Comparative Effectiveness of Nonsteroidal Anti-inflammatory Drug Treatment vs No Treatment for Patent Ductus Arteriosus in Preterm Infants. ( 28046188 )
2017
15
Neonatal Patent Ductus Arteriosus Ligation Operations Performed by Adult Cardiac Surgeons. ( 28795028 )
2017
16
Neurodevelopmental Outcome in Relation to Treatment of Patent Ductus Arteriosus. ( 28846755 )
2017
17
Transcatheter Closure of Patent Ductus Arteriosus in Children with the Occlutech Duct Occluder. ( 28828684 )
2017
18
Tale of Two Patent Ductus Arteriosus Severity Scores: Similarities and Differences. ( 28787748 )
2017
19
Neurodevelopmental Outcome in Relation to Treatment of Patent Ductus Arteriosus. ( 28846759 )
2017
20
Urinary Neutrophil Gelatinase-associated Lipocalin in the evaluation of Patent Ductus Arteriosus and AKI in Very Preterm Neonates: a cohort study. ( 28068947 )
2017
21
Intraoperative High-Frequency Jet Ventilation Is Equivalent to Conventional Ventilation During Patent Ductus Arteriosus Ligation. ( 28901229 )
2017
22
Anatomic, histopathologic, and echocardiographic features in a dog with an atypical pulmonary valve stenosis with a fibrous band of tissue and a patent ductus arteriosus. ( 28697788 )
2017
23
Echocardiographic assessment of patent ductus arteriosus in very low birthweight infants over time: prospective observational study. ( 28043190 )
2017
24
Paracetamol in Patent Ductus Arteriosus Treatment: Efficacious and Safe? ( 28828381 )
2017
25
Transcatheter Occlusion of the Patent Ductus Arteriosus in 747 InfantsA <6 kg: Insights From the NCDR IMPACT Registry. ( 28823780 )
2017
26
Isolated left brachiocephalic artery with the right aortic arch: A rare differential of large patent ductus arteriosus. ( 28163435 )
2017
27
Incidence of postoperative implant-related bacterial endocarditis in dogs that underwent trans-catheter embolization of a patent ductus arteriosus without intra- and post-procedural prophylactic antibiotics. ( 28757032 )
2017
28
Patent Ductus Arteriosus in Preterm Infants, Part 1: Understanding the Pathophysiologic Link Between the Patent Ductus Arteriosus and Clinical Complications. ( 28847349 )
2017
29
Comparison of the Mortality and In-Hospital Outcomes of Preterm Infants Treated with Ibuprofen for Patent Ductus Arteriosus with or without Clinical Symptoms Attributable to the Patent Ductus Arteriosus at the Time of Ibuprofen Treatment. ( 27914140 )
2017
30
Outcome after transcatheter occlusion of patent ductus arteriosus in infants less than 6 kg: A national study from United Kingdom and Ireland. ( 28799706 )
2017
31
Relationship between Device Size and Body Weight in Dogs with Patent Ductus Arteriosus Undergoing Amplatz Canine Duct Occluder Deployment. ( 28782853 )
2017
32
Percutaneous Patent Ductus Arteriosus (PDA) Closure During Infancy: A Meta-analysis. ( 28087683 )
2017
33
Meta-Analysis of the Effect of Chest Shielding on Preventing Patent Ductus Arteriosus in Premature Infants. ( 27571485 )
2016
34
Short-Term Outcomes of Patent Ductus Arteriosus Closure With New OcclutechAr Duct Occluder: A Multicenter Study. ( 27090770 )
2016
35
An Elevation of Serum Ferritin Level Might Increase Clinical Risk for the Persistence of Patent Ductus Arteriosus, Sepsis and Bronchopulmonary Dysplasia in Erythropoietin-Treated Very-Low-Birth-Weight Infants. ( 27547966 )
2016
36
Thoracic Stent Graft Implantation for Aortic Coarctation with Patent Ductus Arteriosus via Retroperitoneal Iliac Approach in the Presence of Small Sized Femoral Artery. ( 27242935 )
2016
37
Pathophysiology of Patent Ductus Arteriosus in the Preterm Infant. ( 27197953 )
2016
38
Cardiac biomarkers and haemodynamically significant patent ductus arteriosus in preterm infants. ( 27998626 )
2016
39
A conservative treatment of patent ductus arteriosus in very low birth weight infants. ( 28042972 )
2016
40
Elevated Nucleated Red Blood Cells at Birth Predict Hemodynamically Significant Patent Ductus Arteriosus. ( 27522442 )
2016
41
Isolation of Left Common Carotid Artery with Its Origin Proximal to Patent Ductus Arteriosus Presenting in Adult Age. ( 27213071 )
2016
42
Transcatheter Echocardiographic-Guided Closure of Patent Ductus Arteriosus in Extremely Premature Newborns. ( 27931596 )
2016
43
Counter-clockwise vortical blood flow in the main pulmonary artery in a patient with patent ductus arteriosus with pulmonary arterial hypertension: a cardiac magnetic resonance imaging case report. ( 27501792 )
2016
44
Near-infrared spectroscopy for detection of a significant patent ductus arteriosus. ( 27603562 )
2016
45
B-type natriuretic peptide levels normalise in preterm infants without a patent ductus arteriosus by the fifth postnatal day. ( 27206680 )
2016
46
Follow-Up Results of Device Occlusion of Patent Ductus Arteriosus. ( 27617065 )
2016
47
Trends and Variation in Management and Outcomes of Very Low Birth Weight Infants with Patent Ductus Arteriosus. ( 27509008 )
2016
48
Surgical Ligation for Patent Ductus Arteriosus in Extremely Premature Infants: Strategy to Reduce their Risk of Neurodevelopmental Impairment. ( 27558322 )
2016
49
Patent Ductus Arteriosus and Short- and Long-Term Respiratory Outcomes. ( 27603534 )
2016
50
Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus. ( 27716515 )
2016

Variations for Patent Ductus Arteriosus

Expression for Patent Ductus Arteriosus

Search GEO for disease gene expression data for Patent Ductus Arteriosus.

Pathways for Patent Ductus Arteriosus

GO Terms for Patent Ductus Arteriosus

Cellular components related to Patent Ductus Arteriosus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ATP-sensitive potassium channel complex GO:0008282 8.62 ABCC9 KCNJ8

Biological processes related to Patent Ductus Arteriosus according to GeneCards Suite gene sharing:

(show all 25)
id Name GO ID Score Top Affiliating Genes
1 cellular response to hypoxia GO:0071456 9.77 EDN1 GATA6 PTGS2
2 kidney development GO:0001822 9.77 HPGD KCNJ8 TFAP2B
3 in utero embryonic development GO:0001701 9.73 CHD7 EDN1 GATA6 TGFBR2
4 regulation of blood pressure GO:0008217 9.63 EDN1 NPPB PTGS2
5 positive regulation of smooth muscle contraction GO:0045987 9.62 EDN1 PTGS2
6 prostaglandin metabolic process GO:0006693 9.62 HPGD PTGS2
7 negative regulation of cardiac muscle cell proliferation GO:0060044 9.61 TBX5 TGFBR2
8 regulation of blood vessel size GO:0050880 9.61 EDN1 NPPB
9 lipoxygenase pathway GO:0019372 9.58 HPGD PTGS2
10 prostaglandin biosynthetic process GO:0001516 9.58 EDN1 PTGS2
11 positive regulation of smooth muscle cell proliferation GO:0048661 9.58 EDN1 PTGS2 TGFBR2
12 aorta morphogenesis GO:0035909 9.57 CHD7 TFAP2B
13 positive regulation of renal sodium excretion GO:0035815 9.56 EDN1 NPPB
14 heart development GO:0007507 9.56 EDN1 KCNJ8 TBX5 TGFBR2
15 ovulation GO:0030728 9.55 HPGD PTGS2
16 forelimb morphogenesis GO:0035136 9.54 TBX5 TFAP2B
17 atrioventricular valve morphogenesis GO:0003181 9.52 TBX5 TGFBR2
18 cellular response to mechanical stimulus GO:0071260 9.51 PTGER4 PTGS2
19 response to lithium ion GO:0010226 9.49 PTGS2 TFAP2B
20 body fluid secretion GO:0007589 9.48 EDN1 NPPB
21 ductus arteriosus closure GO:0097070 9.37 HPGD TFAP2B
22 response to lipopolysaccharide GO:0032496 9.35 EDN1 HPGD KCNJ8 PTGER4 PTGS2
23 positive regulation of urine volume GO:0035810 9.33 EDN1 NPPB TFAP2B
24 positive regulation of cardioblast differentiation GO:0051891 9.32 GATA6 TBX5
25 response to drug GO:0042493 9.17 ABCC9 EDN1 GATA6 LCN2 PTGS2 TFAP2B

Molecular functions related to Patent Ductus Arteriosus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 prostaglandin E receptor activity GO:0004957 8.62 HPGD PTGER4

Sources for Patent Ductus Arteriosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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