PAD
MCID: PTN002
MIFTS: 61

Patent Ductus Arteriosus (PAD) malady

Cardiovascular, Fetal, Genetic categories

Summaries for Patent Ductus Arteriosus

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Patent ductus arteriosus (PDA) is a congenital disorder in the heart wherein a neonate\'s ductus... more...

MalaCards: Patent Ductus Arteriosus, also known as patent ductus arteriosus, susceptibility to, is related to ventricular septal defect and char syndrome, and has symptoms including autosomal recessive inheritance, failure to thrive/difficulties for feeding in infancy/growth delay and apnea/sleep apnea. An important gene associated with Patent Ductus Arteriosus is PDA1 (Patent ductus arteriosus, susceptibility to), and among its related pathways is Prostanoid ligand receptors. The compounds homocysteine and prostaglandin e2 have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and lung, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Description from OMIM:47 607411

Aliases & Classifications for Patent Ductus Arteriosus

Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 35MeSH, 57SNOMED-CT, 27ICD9CM, 40NCIt, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal, Genetic
Anatomical: Cardiovascular


Characteristics (Orphanet epidemiological data):

49
patent ductus arteriosus:
Inheritance: Autosomal dominant,Autosomal recessive,Multigenic/multifactorial; Prevalence: 1-5/10000; Age of onset: Neonatal/infancy; Age of death: Normal


Aliases & Descriptions:

patent ductus arteriosus 8 43 47 10 49
patent ductus arteriosus, susceptibility to 9
patent ductus arteriosus - persisting type 8
persistent patency of the arterial duct 49
patent ductus arteriosus familial 43
patency of the ductus arteriosus 43
ductus arteriosus patent 45
patent ductus botalli 8
patent arterial duct 49
pad mass 61
pda1 43
pad 49
pda 43


External Ids:

Disease Ontology8 DOID:13832
MeSH35 D004374
ICD9CM27 747.0
NCIt40 C84492
OMIM47 607411
ICD10 via Orphanet26 Q25.0
ICD1025 Q25.0

Related Diseases for Patent Ductus Arteriosus

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Patent Ductus Arteriosus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 259)
idRelated DiseaseScoreTop Affiliating Genes
1ventricular septal defect10.9
2char syndrome10.8
3aortic coarctation10.8
4subacute bacterial endocarditis10.6
5aortic aneurysm10.6
6thrombocytopenia10.6
7pulmonic stenosis10.6
8thoracic aortic aneurysm10.6
9arc syndrome10.6
10aberrant subclavian artery10.6
11bronchopulmonary dysplasia10.6
12eisenmenger syndrome10.6
13adult syndrome10.5
14n syndrome10.5
15patent ductus arteriosus - bicuspid aortic valve - hand anomalies10.5
16congenital patent ductus arteriosus aneurysm10.5
17keratoderma10.4
18biliary atresia10.4
19coronary aneurysm10.4
20brachydactyly10.4
21atrioventricular septal defect10.4
22scimitar syndrome10.4
23aortic incompetence10.4
24atrial heart septal defect10.4
25holt-oram syndrome10.4
26aortic arch interruption10.4
27biliary atresia extrahepatic10.4
28cantu syndrome10.4
29congenital mitral stenosis10.4
30congenital rubella10.4
31coronary artery aneurysm10.4
32gorlin chaudhry moss syndrome10.4
33respiratory distress syndrome, infant10.4
34natal teeth, intestinal pseudoobstruction and patent ductus10.4
35thanatophoric dysplasia type 110.4
36zimmermann-laband syndrome10.4
37pulmonary artery hypoplasia10.4
38pulmonary artery coming from patent ductus arteriosus10.4
39peripheral vascular disease10.4
40hand-foot-genital syndrome10.4
41bart-pumphrey syndrome10.3
42oral submucous fibrosis10.3
43palmoplantar keratoderma, epidermolytic10.3
44thrombocytopenia-absent radius syndrome10.3
45smith-lemli-opitz syndrome10.3
46ebstein anomaly10.3
47primary hypertrophic osteoarthropathy10.3
48marfan syndrome10.3
49rubella10.3
50subclavian steal syndrome10.3

Graphical network of the top 20 diseases related to Patent Ductus Arteriosus:



Diseases related to patent ductus arteriosus

Clinical Features for Patent Ductus Arteriosus

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

607411

Symptoms:

49 (show all 20)
  • autosomal recessive inheritance
  • failure to thrive/difficulties for feeding in infancy/growth delay
  • apnea/sleep apnea
  • autosomal dominant inheritance
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • repeat respiratory infections
  • broad nose/nasal bridge
  • short/small nose
  • asthenia/fatigue/weakness
  • cardiac rhythm disorder/arrhythmia
  • heart/cardiac failure
  • patent ductus arteriosus
  • respiratory rhythm disorder
  • pulmonary hypertension
  • flat face
  • tetralogy of fallot/trilogy of fallot
  • high forehead
  • terminal broadening/clubbing of toes
  • prematurity
  • antenatal exposure : rubella

Drugs & Therapeutics for Patent Ductus Arteriosus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Patent Ductus Arteriosus

Drug clinical trials:

Search ClinicalTrials for Patent Ductus Arteriosus

Search NIH Clinical Center for Patent Ductus Arteriosus

Search CenterWatch for Patent Ductus Arteriosus

Genetic Tests for Patent Ductus Arteriosus

Anatomical Context for Patent Ductus Arteriosus

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Patent Ductus Arteriosus:

33
Liver, Brain, Lung, Heart, Smooth muscle, Small intestine, T cells, B cells, Fetal brain, Fetal liver, Fetal lung

Animal Models for Patent Ductus Arteriosus or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Patent Ductus Arteriosus:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538510.7ZIC3, NPPB, FABP3, TFAP2B, CYP11B1, PTGER1
2MP:000537610.5PTGES2, KCNA5, FOLR1, FABP3, TFAP2B, SHMT1

Publications for Patent Ductus Arteriosus

Sources:
51PubMed
See all sources

Articles related to Patent Ductus Arteriosus:

(show top 50)    (show all 581)
idTitleAuthorsYear
1
A different first-choice drug in the medical management of patent ductus arteriosus: oral paracetamol. (23205872)
2013
2
Oral paracetamol in treatment of closure of patent ductus arteriosus in preterm neonates. (24346391)
2013
3
Patent ductus arteriosus closure using the AmplatzerAr vascular plug II for all anatomic variants. (23074167)
2013
4
Superior Mesenteric Artery Blood Flow Velocities following Medical Treatment of a Patent Ductus Arteriosus. (24321538)
2013
5
Transesophageal Echocardiography Guided Patent Ductus Arteriosus Occlusion with a Duct Occluder. (24118205)
2013
6
Patent ductus arteriosus ligation: Do not take it easy. (24250006)
2013
7
A subpopulation of smooth muscle cells, derived from melanocyte-competent precursors, prevents patent ductus arteriosus. (23382837)
2013
8
B-type natriuretic peptide for assessment of haemodynamically significant patent ductus arteriosus in premature infants. (23611593)
2013
9
Intravenous paracetamol for patent ductus arteriosus in premature infants - a lower dose is also effective. Concerning the article by M.Y. Oncel et al: Intravenous paracetamol treatment in the management of patent ductus arteriosus in extremely low birth weight infants [Neonatology 2013;103:166-169]. (23548678)
2013
10
Unilateral laryngeal paralysis subsequent to surgical ligation of a patent ductus arteriosus in an 8-week-old domestic shorthair cat. (23725437)
2013
11
Enteral feeding during indomethacin and ibuprofen treatment of a patent ductus arteriosus. (23472765)
2013
12
Oral ibuprofen versus intravenous ibuprofen or intravenous indomethacin for the treatment of patent ductus arteriosus in preterm infants: a systematic review and meta-analysis. (22414850)
2012
13
Patent ductus arteriosus associated with pulmonary hypertension and desaturation. (23042324)
2012
14
Patent ductus arteriosus: mechanisms and management. (22414878)
2012
15
Value of the echocardiographic suprasternal view for diagnosis of patent ductus arteriosus subtypes. (22922622)
2012
16
Oral ibuprofen versus intravenous indomethacin for closure of patent ductus arteriosus in very low birth weight infants. (23276438)
2012
17
Hydrocortisone for refractory hypotension of very low birth weight infant with patent ductus arteriosus: a case report. (22012173)
2012
18
A new type of aortic arch interruption without significant patent ductus arteriosus and with no ventricular septal defect. (21798564)
2012
19
Transcatheter interruption of large residual flow after device closure of "Type A" patent ductus arteriosus. (23129919)
2012
20
Adult patient with Shone's syndrome and patent ductus arteriosus: a case report. (22951852)
2012
21
A rare association with patent ductus arteriosus. (23129912)
2012
22
Treatment of patent ductus arteriosus with bidirectional flow in neonates. (21402454)
2011
23
Large tortuous patent ductus arteriosus with proximal left pulmonary artery hypoplasia. (23804012)
2011
24
Patent ductus arteriosus in a family of Chihuahuas. (21906065)
2011
25
Transthoracic echocardiographic guidance of patent ductus arteriosus occlusion with an AmplatzAr canine duct occluder. (20646727)
2011
26
Familial nonsyndromic patent ductus arteriosus caused by mutations in TFAP2B. (21643846)
2011
27
Transcatheter closure of a patent ductus arteriosus in a preterm infant with an Amplatzer Vascular Plug IV device. (20517997)
2011
28
Therapeutic changes of plasma N-terminal pro-brain natriuretic peptide concentrations in 9 dogs with patent ductus arteriosus. (20823663)
2011
29
Patent ductus arteriosus: wait and see? (21830997)
2011
30
Hybrid endovascular stent-grafting technique for patent ductus arteriosus in an adult. (21432760)
2011
31
Aortic valve regurgitation following percutaneous closure of patent ductus arteriosus. (21328683)
2011
32
Comparison of posterolateral thoracotomy and video-assisted thoracoscopic clipping for the treatment of patent ductus arteriosus in neonates and infants. (21188372)
2011
33
Safe retrieval of embolized patent ductus arteriosus coil via left thoracotomy. (20959885)
2010
34
Patent ductus arteriosus of the preterm infant. (20421261)
2010
35
Management of patent ductus arteriosus in term or near-term neonates with respiratory distress. (20675240)
2010
36
The patent ductus arteriosus-multiple defects and a moving target. (20976751)
2010
37
A variant of tetralogy of Fallot with absent pulmonary valve: left pulmonary artery originate from left patent ductus arteriosus. (19830376)
2010
38
Is cerebral oxygen supply compromised in preterm infants undergoing surgical closure for patent ductus arteriosus? (20584797)
2010
39
Transcatheter closure of a patent ductus arteriosus in a patient with an anomalous inferior vena cava. (20607224)
2010
40
Unusual presentation for a patent ductus arteriosus. (20956139)
2009
41
Familial thoracic aortic aneurysm/dissection with patent ductus arteriosus: genetic arguments for a particular pathophysiological entity. (14722581)
2004
42
Anesthetic management for a hypertensive patent ductus arteriosus (PDA) closure in a patient with surgically uncorrectable long-segment right pulmonary artery hypoplasia and a ventricular septal defect. (14689417)
2003
43
Molecular determinants of atrial and ventricular septal defects and patent ductus arteriosus. (11376442)
2000
44
The effect of tolazoline on right-to-left shunting via a patent ductus arteriosus in meconium aspiration syndrome. (803084)
1976
45
Patent ductus arteriosus, aorto-pulmonary artery fenestration, coarctation of the aorta and pulmonic stenosis. (5138242)
1971
46
Scimitar syndrome associated with patent ductus arteriosus, aortic coarctation and irreversible pulmonary hypertension. (4236474)
1968
47
The Surgical Treatment of a Persistent Right Aortic Arch and Patent Ductus Arteriosus in a Dog. (17421732)
1964
48
Ventricular septal defect with aortic incompetence simulating patent ductus arteriosus. (13469748)
1957
49
Patent ductus arteriosus and congenital mitral stenosis. (13016487)
1953
50
Cure of subacute bacterial endocarditis by surgical ligation of the patent ductus arteriosus. (12993436)
1952

Genetic Variations for Patent Ductus Arteriosus

Expression for genes affiliated with Patent Ductus Arteriosus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Patent Ductus Arteriosus

Search GEO for disease gene expression data for Patent Ductus Arteriosus.

Pathways for genes affiliated with Patent Ductus Arteriosus

Sources:
54Reactome, 38NCBI BioSystems Database
See all sources

Pathways related to Patent Ductus Arteriosus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5PTGER2, PTGER1

Compounds for genes affiliated with Patent Ductus Arteriosus

Sources:
45Novoseek, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB
See all sources

Compounds related to Patent Ductus Arteriosus according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1homocysteine45 2412.0APOC2, NPPB, FOLR1, SHMT1
2prostaglandin e260 2412.0PTGES2, PTGER2, PTGER1
316, 16-dimethyl pge-24511.0PTGER2, PTGER1
4dihydrofolate4510.9FOLR1, GART, SHMT1
5gr 63799x4510.9PTGER1, PTGER2
6ah68092910.9PTGER1, PTGER2
717-phenyl-trinor-pge24510.9PTGER1, PTGER2
8bw245c4510.9PTGER1, PTGER2
9ah 68094510.9PTGER1, PTGER2
10thallium4510.9NPPB, FABP3
11lometrexol4510.9FOLR1, GART
12m&b 287672910.9PTGER1, PTGER2
13[3h]pge22910.9PTGER1, PTGER2
14pgd22910.9PTGER1, PTGER2
15ah2384845 2911.9PTGER1, PTGER2
16Alprostadil1110.9PTGER1, PTGER2
17enprostil29 4511.9PTGER1, PTGER2
18pgf2910.9PTGER1, PTGER2
19l-161,9826010.9PTGER1, PTGER2
20l-798,10660 2911.9PTGER1, PTGER2
21butaprost4510.9PTGER2, PTGER1
22u 466196010.9PTGER2, PTGER1
23-, methyl ester4510.8PTGER2, PTGER1
2411-deoxy-pge14510.8PTGER2, PTGER1
25pge22910.8PTGER1, PTGER2
26u4661929 4511.8PTGER1, PTGER2
27bupivacaine45 29 1112.8KCNA5, PTGER1
28sulprostone45 2911.8PTGER1, PTGER2
29misoprostol45 1111.8PTGER2, PTGER1
30tomudex4510.8FOLR1, GART
31thymidylate4510.7FOLR1, GART, SHMT1
32carbacyclin45 2911.7PTGER2, PTGER1
33Tetrahydrofolic acid11 2411.7SHMT1, GART
34mibg4510.6FABP3, NPPB
35aldosterone29 11 2412.6NPPB, CYP11B1
36forskolin45 50 1112.5CYP11B1, NPPB
37pge24510.5PTGES2
38Dinoprostone1110.4PTGER2, PTGER1
39arachidonic acid45 29 11 2413.3FABP3, PTGER1, PTGER2, PTGES2

GO Terms for genes affiliated with Patent Ductus Arteriosus

Sources:
16Gene Ontology
See all sources

Biological processes related to Patent Ductus Arteriosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of urine volumeGO:03581010.5TFAP2B, NPPB
2purine nucleobase biosynthetic processGO:00911310.5SHMT1, GART
3potassium ion homeostasisGO:05507510.4TFAP2B, KCNA5
4folic acid metabolic processGO:04665510.2SHMT1, FOLR1

Molecular functions related to Patent Ductus Arteriosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipid bindingGO:00828910.6FABP3, APOC2, BPIFA1
2prostaglandin E receptor activityGO:00495710.2PTGER2, PTGER1

Products for genes affiliated with Patent Ductus Arteriosus

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Patent Ductus Arteriosus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet