PAD
MCID: PTN002
MIFTS: 57

Patent Ductus Arteriosus (PAD) malady

Genetic diseases, Rare diseases, Cardiovascular diseases, Fetal diseases categories
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Summaries for Patent Ductus Arteriosus

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Wikipedia:65 Patent ductus arteriosus (PDA) is a congenital disorder in the heart wherein a neonate\'s ductus... more...

MalaCards based summary: Patent Ductus Arteriosus, also known as PAD, is related to insulin resistance and hypertension, and has symptoms including short/small nose, respiratory distress/dyspnea/respiratory failure/lung volume reduction and patent ductus arteriosus. An important gene associated with Patent Ductus Arteriosus is PDA1 (Patent ductus arteriosus, susceptibility to). The compounds arachidonic acid and mspi have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related mouse phenotype homeostasis/metabolism.

Description from OMIM:46 607411

Aliases & Classifications for Patent Ductus Arteriosus

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Sources:
48Orphanet, 62UMLS, 8Disease Ontology, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 9diseasecard, 44Novoseek, 57SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Patent Ductus Arteriosus, Aliases & Descriptions:

Name: Patent Ductus Arteriosus 8 42 46 10 48
Pad 48 62
Patent Ductus Arteriosus, Susceptibility to 9
Persistent Patency of the Arterial Duct 48
Patent Ductus Arteriosus Familial 42
Patency of the Ductus Arteriosus 42
 
Ductus Arteriosus Patent 44
Patent Ductus Botalli 8
Patent Arterial Duct 48
Pda1 42
Pda 42


Classifications:



Characteristics (Orphanet epidemiological data):

48
patent ductus arteriosus:
Inheritance: Autosomal dominant,Autosomal recessive,Multigenic/multifactorial; Prevalence: 1-5/10000; Age of onset: Neonatal/infancy; Age of death: Normal


External Ids:

Disease Ontology8 DOID:13832
NCIt39 C84492
MeSH34 D004374
ICD9CM27 747.0
OMIM46 607411
ICD10 via Orphanet26 Q25.0
UMLS via Orphanet63 C0013274
ICD1025 Q25.0

Related Diseases for Patent Ductus Arteriosus

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Diseases related to Patent Ductus Arteriosus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 207)
idRelated DiseaseScoreTop Affiliating Genes
1insulin resistance30.1TFAP2B, APOA4, FABP3
2hypertension10.9
3ventricular septal defect10.9
4aneurysm10.9
5pulmonary hypertension10.9
6right aortic arch10.8
7char syndrome10.8
8aortic coarctation10.8
9endocarditis10.7
10cerebritis10.7
11thrombocytopenia10.6
12subacute bacterial endocarditis10.6
13eisenmenger syndrome10.6
14pulmonic stenosis10.6
15bronchopulmonary dysplasia10.6
16thoracic aortic aneurysm10.6
17aortic aneurysm10.6
18tetralogy of fallot10.5
19congenital heart disease10.5
20esophagitis10.5
21intestinal perforation10.5
22pulmonary atresia with intact ventricular septum10.5
23coronary arterial fistulas10.5
24patent ductus arteriosus - bicuspid aortic valve - hand anomalies10.5
25aortic arch interruption10.4
26hemangioma10.4
27biliary atresia10.4
28brachydactyly10.4
29scimitar syndrome10.4
30infective endocarditis10.4
31intestinal pseudo-obstruction10.4
32holt-oram syndrome10.4
33cantu syndrome10.4
34congenital mitral stenosis10.4
35congenital rubella10.4
36cor triatriatum10.4
37coronary artery aneurysm10.4
38gorlin chaudhry moss syndrome10.4
39natal teeth, intestinal pseudoobstruction and patent ductus10.4
40sternal cleft10.4
41thanatophoric dysplasia type 110.4
42zimmermann-laband syndrome10.4
43pulmonary artery hypoplasia10.4
44congenital patent ductus arteriosus aneurysm10.4
45pulmonary artery coming from patent ductus arteriosus10.4
46hand-foot-genital syndrome10.4
47transposition of the great arteries10.4
48alagille syndrome10.3
49atherosclerosis10.3
50congestive heart failure10.3

Graphical network of the top 20 diseases related to Patent Ductus Arteriosus:



Diseases related to patent ductus arteriosus

Symptoms for Patent Ductus Arteriosus

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Clinical features from OMIM:

607411

Symptoms:

48 (show all 20)
  • short/small nose
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • patent ductus arteriosus
  • autosomal dominant inheritance
  • asthenia/fatigue/weakness
  • high forehead
  • flat face
  • broad nose/nasal bridge
  • respiratory rhythm disorder
  • apnea/sleep apnea
  • pulmonary hypertension
  • repeat respiratory infections
  • cardiac rhythm disorder/arrhythmia
  • heart/cardiac failure
  • failure to thrive/difficulties for feeding in infancy/growth delay
  • prematurity
  • terminal broadening/clubbing of toes
  • tetralogy of fallot/trilogy of fallot
  • autosomal recessive inheritance
  • antenatal exposure : rubella

HPO human phenotypes related to Patent Ductus Arteriosus:

(show all 13)
id Description Frequency HPO Source Accession
1 patent ductus arteriosus hallmark (90%) HP:0001643
2 respiratory insufficiency hallmark (90%) HP:0002093
3 short nose hallmark (90%) HP:0003196
4 malar flattening typical (50%) HP:0000272
5 high forehead typical (50%) HP:0000348
6 premature birth typical (50%) HP:0001622
7 congestive heart failure typical (50%) HP:0001635
8 pulmonary hypertension typical (50%) HP:0002092
9 apnea typical (50%) HP:0002104
10 recurrent respiratory infections typical (50%) HP:0002205
11 arrhythmia typical (50%) HP:0011675
12 tetralogy of fallot occasional (7.5%) HP:0001636
13 clubbing of toes occasional (7.5%) HP:0100760

Drugs & Therapeutics for Patent Ductus Arteriosus

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Drug clinical trials:

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Search NIH Clinical Center for Patent Ductus Arteriosus

Genetic Tests for Patent Ductus Arteriosus

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Anatomical Context for Patent Ductus Arteriosus

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MalaCards organs/tissues related to Patent Ductus Arteriosus:

32
Heart, Lung, Brain, Testes, Eye, Smooth muscle, Liver

Animal Models for Patent Ductus Arteriosus or affiliated genes

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MGI Mouse Phenotypes related to Patent Ductus Arteriosus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.2FOLR1, FABP3, APOA4, PTGES2, KCNA5, TFAP2B

Publications for Patent Ductus Arteriosus

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Articles related to Patent Ductus Arteriosus:

(show top 50)    (show all 597)
idTitleAuthorsYear
1
Natural evolution of patent ductus arteriosus in the extremely preterm infant. (25169243)
2014
2
Transcatheter device closure of patent ductus arteriosus. (25327911)
2014
3
A syndrome of insulin resistance resembling Donohue syndrome with patent ductus arteriosus. (24660547)
2014
4
Outcomes of Primary Ligation of Patent Ductus Arteriosus Compared With Secondary Ligation After Pharmacologic Failure in Very-Low-Birth-Weight Infants. (24370764)
2013
5
Unexpected co-arctation of aorta detected by transesophageal echocardiography during patent ductus arteriosus ligation. (23681889)
2013
6
Transcatheter closure of large patent ductus arteriosus using custom made devices. (24323820)
2013
7
A different first-choice drug in the medical management of patent ductus arteriosus: oral paracetamol. (23205872)
2013
8
Patent ductus arteriosus detected on 64-multidetector row CT. (23370756)
2013
9
Challenges in device closure of a large patent ductus arteriosus in infants weighing less than 6 kg. (23017089)
2013
10
Serum ibuprofen levels of extremely preterm infants treated prophylactically with oral ibuprofen to prevent patent ductus arteriosus. (23128963)
2013
11
Long-Term Outcome in Dogs with Patent Ductus Arteriosus: 520 Cases (1994-2009). (24372855)
2013
12
Closure of patent ductus arteriosus in children, small infants, and premature babies with Amplatzer duct occluder II additional sizes: multicenter study. (23460349)
2013
13
Interparametric correlation between echocardiographic markers in preterm infants with patent ductus arteriosus. (23370640)
2013
14
Giant aneurysm of the Valsalva sinus associated with multiple coronary artery aneurysms and patent ductus arteriosus. (24092249)
2013
15
Patent ductus arteriosus in an adult amur leopard (Panthera pardus orientalis). (23505729)
2013
16
Patent ductus arteriosus closure using an Amplatzer(a8c) ventricular septal defect closure device. (24294051)
2013
17
Patent ductus arteriosus, low platelets, cyclooxygenase inhibitors, and intraventricular hemorrhage in very low birth weight preterm infants. (23351600)
2013
18
Morphology of the patent ductus arteriosus does not preclude successful patent ductus arteriosus stent implantation in high-risk patients undergoing hybrid stage I palliation: recommendations to optimize ductal stent positioning. (23704074)
2013
19
Stent angioplasty to relieve left pulmonary artery obstruction caused by patent ductus arteriosus device occlusion: bipartisan teamwork by two interventional devices. (23359589)
2013
20
When to treat hemodynamically insignificant patent ductus arteriosus in preterm infants. (24027704)
2012
21
Oral ibuprofen versus intravenous ibuprofen or intravenous indomethacin for the treatment of patent ductus arteriosus in preterm infants: a systematic review and meta-analysis. (22414850)
2012
22
Analyzing the failures of percutaneous closure of the patent ductus arteriosus in patients over 5 kg. (22954562)
2012
23
Use of targeted neonatal echocardiography to prevent postoperative cardiorespiratory instability after patent ductus arteriosus ligation. (22050874)
2012
24
Vocal cord paralysis post patent ductus arteriosus ligation surgery: risks and co-morbidities. (22959601)
2012
25
Thrombocytopenia in the first 24 hours after birth and incidence of patent ductus arteriosus. (22869835)
2012
26
Antenatal calcium channel blocker exposure and subsequent patent ductus arteriosus in extremely low-birth-weight infants. (21861146)
2012
27
Different transcatheter strategies for aortic coarctation associated with patent ductus arteriosus. (22929832)
2012
28
Transcatheter closure of patent ductus arteriosus using ado device: retrospective study of 149 patients. (22754633)
2012
29
Percutaneous closure of a post-traumatic ventricular septal defect with a patent ductus arteriosus occluder. (23184204)
2012
30
Treatment of patent ductus arteriosus with bidirectional flow in neonates. (21402454)
2011
31
Video-assisted thoracoscopic patent ductus arteriosus closure without tube thoracostomy. (21524494)
2011
32
Does thrombocytopenia contribute to patent ductus arteriosus? (21217670)
2011
33
Aneurysm of a patent ductus arteriosus. (21299627)
2011
34
Transcatheter occlusion of patent ductus arteriosus in pre-term infants. (20488412)
2010
35
Safe retrieval of embolized patent ductus arteriosus coil via left thoracotomy. (20959885)
2010
36
Dynamic volume 320-slice CT in the assessment of patent ductus arteriosus for percutaneous closure. (20194213)
2010
37
Interrupted aortic arch diagnosed with loss of femoral pulse in a patient undergoing patent ductus arteriosus ligation -A case report-. (20532057)
2010
38
Subcutaneous fat necrosis of the newborn associated with ventricular septal defect and patent ductus arteriosus. (19702998)
2009
39
Transcatheter closure of patent ductus arteriosus using the amplatzer duct occluder in infants under one year of age. (23040378)
2009
40
Unilateral vocal fold paralysis in premature infants after ligation of patent ductus arteriosus: vascular clip versus suture ligature. (19894404)
2009
41
Response to the case report of pulmonary artery coil migration after management of patent ductus arteriosus in a 65-year-old female patient. (19666447)
2009
42
Role of prophylactic surgical ligation of patent ductus arteriosus in extremely low birth weight infants: Systematic review and implications for clinical practice. (20808624)
2009
43
Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus. (16444274)
2006
44
Maternal and offspring MTHFR gene C677T polymorphism as predictors of congenital atrial septal defect and patent ductus arteriosus. (16373366)
2006
45
Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus. (15353504)
2004
46
Patent ductus arteriosus in fetal valproate syndrome. (14510093)
2003
47
Repair of aortopulmonary window at left thoracotomy for patent ductus arteriosus. (6825496)
1983
48
The effect of tolazoline on right-to-left shunting via a patent ductus arteriosus in meconium aspiration syndrome. (803084)
1976
49
Aortic arch interruption associated with patent ductus arteriosus, ventricular septal defect, and total anomalous pulmonary venous connection. Total correction in an 8-day-old infant by means of profound hypothermia and limited cardiopulmonary bypass. (5011273)
1972
50
Scimitar syndrome associated with patent ductus arteriosus, aortic coarctation and irreversible pulmonary hypertension. (4236474)
1968

Variations for Patent Ductus Arteriosus

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Expression for genes affiliated with Patent Ductus Arteriosus

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Expression patterns in normal tissues for genes affiliated with Patent Ductus Arteriosus

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Pathways for genes affiliated with Patent Ductus Arteriosus

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Compounds for genes affiliated with Patent Ductus Arteriosus

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Sources:
44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank
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Compounds related to Patent Ductus Arteriosus according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1arachidonic acid44 28 24 1112.1FABP3, PTGES2, EDN2
2mspi449.1FOLR1, APOA4
3glucose448.3FABP3, APOA4, TFAP2B, DEFB1

GO Terms for genes affiliated with Patent Ductus Arteriosus

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Biological processes related to Patent Ductus Arteriosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1potassium ion homeostasisGO:0550759.9KCNA5, TFAP2B
2regulation of insulin secretionGO:0507969.8KCNA5, TFAP2B
3prostaglandin biosynthetic processGO:0015169.7PTGES2, EDN2
4regulation of vasoconstrictionGO:0192299.7EDN2, KCNA5
5cholesterol homeostasisGO:0426329.1FABP3, APOA4

Products for genes affiliated with Patent Ductus Arteriosus

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  • Antibodies
  • Proteins
  • Lysates

Sources for Patent Ductus Arteriosus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet