PAD
MCID: PTN002
MIFTS: 65

Patent Ductus Arteriosus (PAD) malady

Cardiovascular diseases, Fetal diseases, Genetic diseases categories

Summaries for Patent Ductus Arteriosus

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Sources:
63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Patent ductus arteriosus (PDA) is a congenital disorder in the heart wherein a neonate\'s ductus... more...

MalaCards: Patent Ductus Arteriosus, also known as patent ductus arteriosus, susceptibility to, is related to hypertension and breast cancer, and has symptoms including antenatal exposure : rubella, autosomal recessive inheritance and tetralogy of fallot/trilogy of fallot. An important gene associated with Patent Ductus Arteriosus is PDA1 (Patent ductus arteriosus, susceptibility to), and among its related pathways is Prostanoid ligand receptors. The compounds homocysteine and prostaglandin e2 have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Description from OMIM:46 607411

Aliases & Classifications for Patent Ductus Arteriosus

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Sources:
8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM, 39NCIt, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases, Genetic diseases
Anatomical: Cardiovascular diseases


Characteristics (Orphanet epidemiological data):

48
patent ductus arteriosus:
Inheritance: Autosomal dominant,Autosomal recessive,Multigenic/multifactorial; Prevalence: 1-5/10000; Age of onset: Neonatal/infancy; Age of death: Normal


Aliases & Descriptions:

patent ductus arteriosus 8 42 46 10 48
patent ductus arteriosus, susceptibility to 9
patent ductus arteriosus - persisting type 8
persistent patency of the arterial duct 48
patent ductus arteriosus familial 42
patency of the ductus arteriosus 42
ductus arteriosus patent 44
patent ductus botalli 8
patent arterial duct 48
pad mass 60
pda1 42
pad 48
pda 42


External Ids:

Disease Ontology8 DOID:13832
MeSH34 D004374
ICD9CM27 747.0
NCIt39 C84492
OMIM46 607411
ICD10 via Orphanet26 Q25.0
SNOMED-CT via Orphanet57 83330001
ICD1025 Q25.0

Related Diseases for Patent Ductus Arteriosus

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Patent Ductus Arteriosus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 258)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.3KCNA5, NPPB, CYP11B1
2breast cancer30.0FOLR1, FABP3, SHMT1, TRADD, PTGER1, PTGER2
3ventricular septal defect10.9
4char syndrome10.8
5endocarditis10.7
6cerebritis10.7
7subacute bacterial endocarditis10.6
8aortic aneurysm10.6
9thrombocytopenia10.6
10dissecting aortic aneurysm10.5
11thoracic aortic aneurysm10.5
12tetralogy of fallot10.5
13adult syndrome10.5
14esophagitis10.5
15intestinal perforation10.5
16patent ductus arteriosus - bicuspid aortic valve - hand anomalies10.5
17biliary atresia10.4
18coronary aneurysm10.4
19brachydactyly10.4
20atrioventricular septal defect10.4
21scimitar syndrome10.4
22aortic incompetence10.4
23atrial heart septal defect10.4
24heart septal defect10.4
25intestinal obstruction10.4
26intestinal pseudo-obstruction10.4
27pulmonary embolism10.4
28holt-oram syndrome10.4
29cantu syndrome10.4
30gorlin chaudhry moss syndrome10.4
31natal teeth, intestinal pseudoobstruction and patent ductus10.4
32thanatophoric dysplasia type 110.4
33congenital patent ductus arteriosus aneurysm10.4
34pulmonary artery coming from patent ductus arteriosus10.4
35peripheral vascular disease10.4
36hand-foot-genital syndrome10.3
37dermatitis10.3
38bart-pumphrey syndrome10.3
39oral submucous fibrosis10.3
40thrombocytopenia-absent radius syndrome10.2
41smith-lemli-opitz syndrome10.2
42ebstein anomaly10.2
43primary hypertrophic osteoarthropathy10.2
44marfan syndrome10.2
45rubella10.2
46retinopathy of prematurity10.2
47subclavian steal syndrome10.2
48mitral valve prolapse10.2
49klippel-trenaunay syndrome10.2
50hajdu-cheney syndrome10.2

Graphical network of the top 20 diseases related to Patent Ductus Arteriosus:



Diseases related to patent ductus arteriosus

Clinical Features for Patent Ductus Arteriosus

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Sources:
46OMIM, 48Orphanet
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Clinical features from OMIM:

607411

Symptoms:

48 (show all 20)
  • antenatal exposure : rubella
  • autosomal recessive inheritance
  • tetralogy of fallot/trilogy of fallot
  • terminal broadening/clubbing of toes
  • prematurity
  • failure to thrive/difficulties for feeding in infancy/growth delay
  • heart/cardiac failure
  • cardiac rhythm disorder/arrhythmia
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • patent ductus arteriosus
  • autosomal dominant inheritance
  • asthenia/fatigue/weakness
  • high forehead
  • flat face
  • broad nose/nasal bridge
  • respiratory rhythm disorder
  • apnea/sleep apnea
  • pulmonary hypertension
  • repeat respiratory infections
  • short/small nose

Drugs & Therapeutics for Patent Ductus Arteriosus

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Patent Ductus Arteriosus

Drug clinical trials:

Search ClinicalTrials for Patent Ductus Arteriosus

Search NIH Clinical Center for Patent Ductus Arteriosus

Search CenterWatch for Patent Ductus Arteriosus

Genetic Tests for Patent Ductus Arteriosus

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Anatomical Context for Patent Ductus Arteriosus

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Sources:
32MalaCards
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MalaCards organs/tissues related to Patent Ductus Arteriosus:

32
Heart, Lung, Brain, Testes, Eye, Smooth muscle, Liver

Animal Models for Patent Ductus Arteriosus or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Patent Ductus Arteriosus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538510.7ZIC3, NPPB, FABP3, TFAP2B, CYP11B1, PTGER1
2MP:000537610.5PTGES2, KCNA5, FOLR1, FABP3, TFAP2B, SHMT1

Publications for Patent Ductus Arteriosus

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Sources:
50PubMed
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Articles related to Patent Ductus Arteriosus:

(show top 50)    (show all 581)
idTitleAuthorsYear
1
Effect of positive end-expiratory pressure on ductal shunting and systemic blood flow in preterm infants with patent ductus arteriosus. (24193163)
2014
2
Unexpected co-arctation of aorta detected by transesophageal echocardiography during patent ductus arteriosus ligation. (23681889)
2013
3
Long-Term Outcome in Dogs with Patent Ductus Arteriosus: 520 Cases (1994-2009). (24372855)
2013
4
Morphology of the patent ductus arteriosus does not preclude successful patent ductus arteriosus stent implantation in high-risk patients undergoing hybrid stage I palliation: recommendations to optimize ductal stent positioning. (23704074)
2013
5
Stent angioplasty to relieve left pulmonary artery obstruction caused by patent ductus arteriosus device occlusion: bipartisan teamwork by two interventional devices. (23359589)
2013
6
Anomalous left coronary artery from the pulmonary artery with a large patent ductus arteriosus: aversion of a catastrophe. (23095578)
2013
7
Surgical management of an aberrant left subclavian artery originating from a left patent ductus arteriosus in a dog with a right aortic arch and abnormal branching. (23680133)
2013
8
A rare complication of pre-Eisenmenger patent ductus arteriosus: Pulmonary artery dissection. (23562897)
2013
9
Mathematical model of flow through the patent ductus arteriosus. (23053537)
2013
10
Paracetamol to close the patent ductus arteriosus: From serendipity toward evidence based medicine. (24346379)
2013
11
An alternative drug (paracetamol) in the management of patent ductus arteriosus in ibuprofen-resistant or contraindicated preterm infants. (22611117)
2013
12
Early colour Doppler duct diameter and symptomatic patent ductus arteriosus in a cyclo-oxygenase inhibitor naA^ve population. (23181767)
2013
13
An adult patient with coexistence of coarctation of aorta and patent ductus arteriosus: multimodality imaging. (24064097)
2013
14
Elevated urinary NT-proBNP after pharmacological closure of patent ductus arteriosus in very low birth weight infants. (23084575)
2013
15
Safety of percutaneous patent ductus arteriosus closure: an unselected multicenter population experience. (24284214)
2013
16
Oral Ibuprofen and the patent ductus arteriosus: a new approach to an old problem. (23544804)
2013
17
Prevalence and management of patent ductus arteriosus in a pediatric medicaid cohort. (23720302)
2013
18
Randomised controlled clinical trial of standard versus echocardiographically guided ibuprofen treatment for patent ductus arteriosus in preterm infants: a pilot study. (24047189)
2013
19
Use of targeted neonatal echocardiography to prevent postoperative cardiorespiratory instability after patent ductus arteriosus ligation. (22050874)
2012
20
Transcatheter closure of patent ductus arteriosus using ado device: retrospective study of 149 patients. (22754633)
2012
21
Therapeutic strategies, including a high surgical ligation rate, for patent ductus arteriosus closure in extremely premature infants in a North American centre. (23543702)
2012
22
Oral versus intravenous ibuprofen for patent ductus arteriosus closure: a randomised controlled trial in extremely low birthweight infants. (22147286)
2012
23
Left main bronchus obstruction after patent ductus arteriosus ligation: an unusual complication. (23021466)
2012
24
Patent ductus arteriosus--looking for the right approach of management. (22962235)
2012
25
Neurodevelopmental outcomes following two different treatment approaches (early ligation and selective ligation) for patent ductus arteriosus. (22795222)
2012
26
Ligation of patent ductus arteriosus in low birth weight premature infants: timing for intervention and effectiveness of bed-side surgery. (23234577)
2012
27
Endovascular aortic repair of patent ductus arteriosus in an adult patient. (22159231)
2012
28
Successful closure of a patent ductus arteriosus using an aortic stent graft. (21881350)
2012
29
Multidetector-row computed tomography of thoracic aortic anomalies in dogs and cats: patent ductus arteriosus and vascular rings. (21943366)
2011
30
Patent ductus arteriosus in preterm infants. (21532100)
2011
31
Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants. (21735396)
2011
32
A case of pulmonary infective endarteritis associated with patent ductus arteriosus: surgical closure under circulatory arrest. (21850583)
2011
33
Renal safety of Non Steroidal Anti Inflammatory Drugs (NSAIDs) in the pharmacologic treatment of patent ductus arteriosus. (21942591)
2011
34
Long-term outcome of coil occlusion in patients with patent ductus arteriosus. (21173496)
2011
35
Patent ductus arteriosus in adults - indications and possibilities for closure. (21584804)
2011
36
Effect of ibuprofen on bilirubin-albumin binding in vitro at concentrations observed during treatment of patent ductus arteriosus. (20472375)
2010
37
Contrast-enhanced magnetic resonance angiography of patent ductus arteriosus in a dog. (20670257)
2010
38
Patent ductus arteriosus in dogs. (20960409)
2010
39
Migration of an Amplatzer after patent ductus arteriosus closure. (19846317)
2010
40
Total arch replacement with open stent-grafting for aneurysm of ductus arteriosus after surgery for patent ductus arteriosus. (20678114)
2010
41
Reoperation for ascending aorta and total arch replacement combined with patent ductus arteriosus closure in a child with marfan syndrome. (20650834)
2010
42
Feeding practices and patent ductus arteriosus ligation preferences-are they related? (20225172)
2010
43
Recent strategies and outcomes of transcatheter closure for patent ductus arteriosus. (20514330)
2010
44
Esophageal stethoscope: an old tool with a new role, detection of residual flow during video-assisted thoracoscopic patent ductus arteriosus closure. (21034935)
2010
45
Successful closure of left-to-right patent ductus arteriosus in three dogs with concurrent pulmonary hypertension. (20188645)
2010
46
Images in cardiovascular medicine. Real-time 3-dimensional transesophageal echocardiography imaging: adult patent ductus arteriosus before and after transcatheter closure. (19770408)
2009
47
The role of patent ductus arteriosus ligation in bronchopulmonary dysplasia: reexamining a randomized controlled trial. (19324366)
2009
48
Transcatheter closure of patent ductus arteriosus with a self-expanding platinum-coated nitinol device. (19494407)
2009
49
Management of complications that arise during transcatheter closure of atrial septal defects and patent ductus arteriosus. (19845085)
2008
50
Pseudovascular ring resulting from right lung agenesis, normal aortic arch, and patent ductus arteriosus. Case report. (5953538)
1966

Genetic Variations for Patent Ductus Arteriosus

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Expression for genes affiliated with Patent Ductus Arteriosus

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Patent Ductus Arteriosus

Search GEO for disease gene expression data for Patent Ductus Arteriosus.

Pathways for genes affiliated with Patent Ductus Arteriosus

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Sources:
53Reactome, 37NCBI BioSystems Database
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Pathways related to Patent Ductus Arteriosus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5PTGER2, PTGER1

Compounds for genes affiliated with Patent Ductus Arteriosus

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Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB
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Compounds related to Patent Ductus Arteriosus according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1homocysteine44 2412.0APOC2, NPPB, FOLR1, SHMT1
2prostaglandin e259 2412.0PTGES2, PTGER2, PTGER1
316, 16-dimethyl pge-24411.0PTGER2, PTGER1
4dihydrofolate4410.9FOLR1, GART, SHMT1
5gr 63799x4410.9PTGER1, PTGER2
6ah68092810.9PTGER1, PTGER2
717-phenyl-trinor-pge24410.9PTGER1, PTGER2
8bw245c4410.9PTGER1, PTGER2
9ah 68094410.9PTGER1, PTGER2
10thallium4410.9NPPB, FABP3
11lometrexol4410.9FOLR1, GART
12m&b 287672810.9PTGER1, PTGER2
13[3h]pge22810.9PTGER1, PTGER2
14pgd22810.9PTGER1, PTGER2
15ah2384844 2811.9PTGER1, PTGER2
16Alprostadil1110.9PTGER1, PTGER2
17enprostil28 4411.9PTGER1, PTGER2
18pgf2810.9PTGER1, PTGER2
19l-161,9825910.9PTGER1, PTGER2
20l-798,10659 2811.9PTGER1, PTGER2
21butaprost4410.9PTGER2, PTGER1
22u 466195910.9PTGER2, PTGER1
23-, methyl ester4410.8PTGER2, PTGER1
2411-deoxy-pge14410.8PTGER2, PTGER1
25pge22810.8PTGER1, PTGER2
26u4661928 4411.8PTGER1, PTGER2
27bupivacaine44 28 1112.8KCNA5, PTGER1
28sulprostone44 2811.8PTGER1, PTGER2
29misoprostol44 1111.8PTGER2, PTGER1
30tomudex4410.8FOLR1, GART
31thymidylate4410.7FOLR1, GART, SHMT1
32carbacyclin44 2811.7PTGER2, PTGER1
33Tetrahydrofolic acid11 2411.7SHMT1, GART
34mibg4410.6FABP3, NPPB
35aldosterone28 11 2412.6NPPB, CYP11B1
36forskolin44 49 1112.5CYP11B1, NPPB
37pge24410.5PTGES2
38Dinoprostone1110.4PTGER2, PTGER1
39arachidonic acid44 28 11 2413.3FABP3, PTGER1, PTGER2, PTGES2

GO Terms for genes affiliated with Patent Ductus Arteriosus

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Sources:
16Gene Ontology
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Biological processes related to Patent Ductus Arteriosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of urine volumeGO:03581010.5TFAP2B, NPPB
2purine nucleobase biosynthetic processGO:00911310.5SHMT1, GART
3potassium ion homeostasisGO:05507510.4TFAP2B, KCNA5
4folic acid metabolic processGO:04665510.2SHMT1, FOLR1

Molecular functions related to Patent Ductus Arteriosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipid bindingGO:00828910.6FABP3, APOC2, BPIFA1
2prostaglandin E receptor activityGO:00495710.2PTGER2, PTGER1

Products for genes affiliated with Patent Ductus Arteriosus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Patent Ductus Arteriosus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet