MCID: PTN002
MIFTS: 49

Patent Ductus Arteriosus malady

Genetic diseases, Rare diseases, Cardiovascular diseases, Fetal diseases categories

Summaries for Patent Ductus Arteriosus

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Wikipedia:63 Patent ductus arteriosus (PDA) is a congenital disorder in the heart wherein a neonate\'s ductus... more...

MalaCards based summary: Patent Ductus Arteriosus, also known as persistent patency of the arterial duct, is related to primary hyperoxaluria and ventricular septal defect, and has symptoms including patent ductus arteriosus, respiratory insufficiency and short nose. An important gene associated with Patent Ductus Arteriosus is TFAP2B (transcription factor AP-2 beta (activating enhancer binding protein 2 beta)). The compounds mspi and arachidonic acid have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related mouse phenotypes are immune system and homeostasis/metabolism.

Aliases & Classifications for Patent Ductus Arteriosus

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Sources:
41NIH Rare Diseases, 47Orphanet, 9Disease Ontology, 11DISEASES, 10diseasecard, 43Novoseek, 60UMLS, 27ICD9CM, 55SNOMED-CT, 33MeSH, 38NCIt, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Patent Ductus Arteriosus, Aliases & Descriptions:

Name: Patent Ductus Arteriosus 9 41 11 47
Persistent Patency of the Arterial Duct 41 47
Patent Arterial Duct 41 47
Pad 41 47
Patent Ductus Arteriosus, Susceptibility to 10
Patent Ductus Arteriosus Familial 41
 
Patency of the Ductus Arteriosus 41
Ductus Arteriosus Patent 43
Patent Ductus Botalli 9
Pad Mass 60
Pda1 41
Pda 41


Classifications:



Characteristics (Orphanet epidemiological data):

47
patent ductus arteriosus:
Inheritance: Autosomal dominant,Autosomal recessive,Multigenic/multifactorial; Prevalence: 1-5/10000 (Europe); Age of onset: Neonatal; Age of death: normal life expectancy


External Ids:

Disease Ontology9 DOID:13832
ICD9CM27 747.0
MeSH33 D004374
NCIt38 C84492
Orphanet47 706
ICD10 via Orphanet26 Q25.0
UMLS via Orphanet61 C0013274
ICD1025 Q25.0

Related Diseases for Patent Ductus Arteriosus

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Diseases related to Patent Ductus Arteriosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 258)
idRelated DiseaseScoreTop Affiliating Genes
1primary hyperoxaluria30.2FABP3, APOA4, EDN2
2ventricular septal defect10.9
3aneurysm10.9
4char syndrome10.8
5pulmonary hypertension10.8
6aortic coarctation10.8
7endocarditis10.7
8holt-oram syndrome10.7
9cerebritis10.7
10eisenmenger syndrome10.7
11bronchopulmonary dysplasia10.6
12thrombocytopenia10.6
13gorlin chaudhry moss syndrome10.6
14pulmonic stenosis10.6
15zimmermann-laband syndrome10.6
16thanatophoric dysplasia, type i10.6
17hypertrichotic osteochondrodysplasia10.6
18subacute bacterial endocarditis10.6
19thoracic aortic aneurysm10.6
20aortic aneurysm10.6
21restrictive dermopathy, lethal10.5
22desmosterolosis10.5
23mowat-wilson syndrome10.5
24microphthalmia, syndromic 310.5
25sotos syndrome 110.5
26tetralogy of fallot10.5
27smith-lemli-opitz syndrome10.5
28feingold syndrome10.5
29intestinal pseudoobstruction, neuronal10.5
30eagle-barrett syndrome10.5
31congenital heart disease10.5
32esophagitis10.5
33intestinal perforation10.5
34congenital rubella10.5
35natal teeth, intestinal pseudoobstruction and patent ductus10.5
36pulmonary atresia with intact ventricular septum10.5
37congenital patent ductus arteriosus aneurysm10.5
38pulmonary artery coming from patent ductus arteriosus10.5
39orotic aciduria10.4
40thanatophoric dysplasia, type ii10.4
41treacher collins syndrome 110.4
42pallister-hall syndrome10.4
43williams-beuren syndrome10.4
44klippel-trenaunay-weber syndrome10.4
45meacham syndrome10.4
46aortic aneurysm, familial thoracic 410.4
47townes-brocks syndrome10.4
48fanconi anemia, complementation group a10.4
49lymphedema-distichiasis syndrome10.4
50mckusick-kaufman syndrome10.4

Graphical network of the top 20 diseases related to Patent Ductus Arteriosus:



Diseases related to patent ductus arteriosus

Symptoms for Patent Ductus Arteriosus

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Symptoms:

 47 (show all 20)
  • short/small nose
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • patent ductus arteriosus
  • autosomal dominant inheritance
  • asthenia/fatigue/weakness
  • high forehead
  • flat face
  • broad nose/nasal bridge
  • respiratory rhythm disorder
  • apnea/sleep apnea
  • pulmonary hypertension
  • repeat respiratory infections
  • cardiac rhythm disorder/arrhythmia
  • heart/cardiac failure
  • failure to thrive/difficulties for feeding in infancy/growth delay
  • prematurity
  • terminal broadening/clubbing of toes
  • tetralogy of fallot/trilogy of fallot
  • autosomal recessive inheritance
  • antenatal exposure : rubella

HPO human phenotypes related to Patent Ductus Arteriosus:

(show all 13)
id Description Frequency HPO Source Accession
1 patent ductus arteriosus hallmark (90%) HP:0001643
2 respiratory insufficiency hallmark (90%) HP:0002093
3 short nose hallmark (90%) HP:0003196
4 malar flattening typical (50%) HP:0000272
5 high forehead typical (50%) HP:0000348
6 premature birth typical (50%) HP:0001622
7 congestive heart failure typical (50%) HP:0001635
8 pulmonary hypertension typical (50%) HP:0002092
9 apnea typical (50%) HP:0002104
10 recurrent respiratory infections typical (50%) HP:0002205
11 arrhythmia typical (50%) HP:0011675
12 tetralogy of fallot occasional (7.5%) HP:0001636
13 clubbing of toes occasional (7.5%) HP:0100760

Drugs & Therapeutics for Patent Ductus Arteriosus

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Drug clinical trials:

Search ClinicalTrials for Patent Ductus Arteriosus

Search NIH Clinical Center for Patent Ductus Arteriosus

Genetic Tests for Patent Ductus Arteriosus

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Anatomical Context for Patent Ductus Arteriosus

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MalaCards organs/tissues related to Patent Ductus Arteriosus:

31
Heart, Lung, Brain, Testes, Eye, Smooth muscle, Liver

Animal Models for Patent Ductus Arteriosus or affiliated genes

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MGI Mouse Phenotypes related to Patent Ductus Arteriosus:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.1IL10RA, BPIFA1, APOA4, PTGES2, KCNA5, DEFB1
2MP:00053766.8IL10RA, EDN2, TFAP2B, KCNA5, PTGES2, APOA4

Publications for Patent Ductus Arteriosus

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Articles related to Patent Ductus Arteriosus:

(show top 50)    (show all 619)
idTitleAuthorsYear
1
Association between Hemodynamically Significant Patent Ductus Arteriosus and Bronchopulmonary Dysplasia. (25882876)
2015
2
Transcatheter Closure of Patent Ductus Arteriosus in Under 6a88kg and Premature Infants. (25832591)
2015
3
Efficacy of a first course of Ibuprofen for patent ductus arteriosus closure in extremely preterm newborns according to their gestational age-specific z-score for birth weight. (25875583)
2015
4
Natural evolution of patent ductus arteriosus in the extremely preterm infant. (25169243)
2014
5
Transcatheter device closure of patent ductus arteriosus. (25327911)
2014
6
A syndrome of insulin resistance resembling Donohue syndrome with patent ductus arteriosus. (24660547)
2014
7
Outcomes of Primary Ligation of Patent Ductus Arteriosus Compared With Secondary Ligation After Pharmacologic Failure in Very-Low-Birth-Weight Infants. (24370764)
2013
8
Unexpected co-arctation of aorta detected by transesophageal echocardiography during patent ductus arteriosus ligation. (23681889)
2013
9
Transcatheter closure of large patent ductus arteriosus using custom made devices. (24323820)
2013
10
A different first-choice drug in the medical management of patent ductus arteriosus: oral paracetamol. (23205872)
2013
11
Patent ductus arteriosus detected on 64-multidetector row CT. (23370756)
2013
12
Challenges in device closure of a large patent ductus arteriosus in infants weighing less than 6 kg. (23017089)
2013
13
Serum ibuprofen levels of extremely preterm infants treated prophylactically with oral ibuprofen to prevent patent ductus arteriosus. (23128963)
2013
14
Long-Term Outcome in Dogs with Patent Ductus Arteriosus: 520 Cases (1994-2009). (24372855)
2013
15
Closure of patent ductus arteriosus in children, small infants, and premature babies with Amplatzer duct occluder II additional sizes: multicenter study. (23460349)
2013
16
Interparametric correlation between echocardiographic markers in preterm infants with patent ductus arteriosus. (23370640)
2013
17
Giant aneurysm of the Valsalva sinus associated with multiple coronary artery aneurysms and patent ductus arteriosus. (24092249)
2013
18
Patent ductus arteriosus in an adult amur leopard (Panthera pardus orientalis). (23505729)
2013
19
Patent ductus arteriosus closure using an Amplatzer(a8c) ventricular septal defect closure device. (24294051)
2013
20
Patent ductus arteriosus, low platelets, cyclooxygenase inhibitors, and intraventricular hemorrhage in very low birth weight preterm infants. (23351600)
2013
21
Morphology of the patent ductus arteriosus does not preclude successful patent ductus arteriosus stent implantation in high-risk patients undergoing hybrid stage I palliation: recommendations to optimize ductal stent positioning. (23704074)
2013
22
Stent angioplasty to relieve left pulmonary artery obstruction caused by patent ductus arteriosus device occlusion: bipartisan teamwork by two interventional devices. (23359589)
2013
23
When to treat hemodynamically insignificant patent ductus arteriosus in preterm infants. (24027704)
2012
24
Oral ibuprofen versus intravenous ibuprofen or intravenous indomethacin for the treatment of patent ductus arteriosus in preterm infants: a systematic review and meta-analysis. (22414850)
2012
25
Analyzing the failures of percutaneous closure of the patent ductus arteriosus in patients over 5 kg. (22954562)
2012
26
Use of targeted neonatal echocardiography to prevent postoperative cardiorespiratory instability after patent ductus arteriosus ligation. (22050874)
2012
27
Vocal cord paralysis post patent ductus arteriosus ligation surgery: risks and co-morbidities. (22959601)
2012
28
Thrombocytopenia in the first 24 hours after birth and incidence of patent ductus arteriosus. (22869835)
2012
29
Antenatal calcium channel blocker exposure and subsequent patent ductus arteriosus in extremely low-birth-weight infants. (21861146)
2012
30
Different transcatheter strategies for aortic coarctation associated with patent ductus arteriosus. (22929832)
2012
31
Transcatheter closure of patent ductus arteriosus using ado device: retrospective study of 149 patients. (22754633)
2012
32
Percutaneous closure of a post-traumatic ventricular septal defect with a patent ductus arteriosus occluder. (23184204)
2012
33
Treatment of patent ductus arteriosus with bidirectional flow in neonates. (21402454)
2011
34
Video-assisted thoracoscopic patent ductus arteriosus closure without tube thoracostomy. (21524494)
2011
35
Does thrombocytopenia contribute to patent ductus arteriosus? (21217670)
2011
36
Transcatheter occlusion of patent ductus arteriosus in pre-term infants. (20488412)
2010
37
Safe retrieval of embolized patent ductus arteriosus coil via left thoracotomy. (20959885)
2010
38
Dynamic volume 320-slice CT in the assessment of patent ductus arteriosus for percutaneous closure. (20194213)
2010
39
Interrupted aortic arch diagnosed with loss of femoral pulse in a patient undergoing patent ductus arteriosus ligation -A case report-. (20532057)
2010
40
Subcutaneous fat necrosis of the newborn associated with ventricular septal defect and patent ductus arteriosus. (19702998)
2009
41
Transcatheter closure of patent ductus arteriosus using the amplatzer duct occluder in infants under one year of age. (23040378)
2009
42
Unilateral vocal fold paralysis in premature infants after ligation of patent ductus arteriosus: vascular clip versus suture ligature. (19894404)
2009
43
Response to the case report of pulmonary artery coil migration after management of patent ductus arteriosus in a 65-year-old female patient. (19666447)
2009
44
Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus. (16444274)
2006
45
Maternal and offspring MTHFR gene C677T polymorphism as predictors of congenital atrial septal defect and patent ductus arteriosus. (16373366)
2006
46
Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus. (15353504)
2004
47
Patent ductus arteriosus in fetal valproate syndrome. (14510093)
2003
48
The effect of tolazoline on right-to-left shunting via a patent ductus arteriosus in meconium aspiration syndrome. (803084)
1976
49
Aortic arch interruption associated with patent ductus arteriosus, ventricular septal defect, and total anomalous pulmonary venous connection. Total correction in an 8-day-old infant by means of profound hypothermia and limited cardiopulmonary bypass. (5011273)
1972
50
Scimitar syndrome associated with patent ductus arteriosus, aortic coarctation and irreversible pulmonary hypertension. (4236474)
1968

Variations for Patent Ductus Arteriosus

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Expression for genes affiliated with Patent Ductus Arteriosus

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Search GEO for disease gene expression data for Patent Ductus Arteriosus.

Pathways for genes affiliated with Patent Ductus Arteriosus

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Compounds for genes affiliated with Patent Ductus Arteriosus

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Sources:
43Novoseek, 28IUPHAR, 24HMDB, 12DrugBank
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Compounds related to Patent Ductus Arteriosus according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1mspi439.3FOLR1, APOA4
2arachidonic acid43 28 24 1212.3FABP3, PTGES2, EDN2
3glucose438.5FABP3, APOA4, TFAP2B, DEFB1

GO Terms for genes affiliated with Patent Ductus Arteriosus

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Biological processes related to Patent Ductus Arteriosus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1potassium ion homeostasisGO:00550759.9KCNA5, TFAP2B
2regulation of insulin secretionGO:00507969.9KCNA5, TFAP2B
3prostaglandin biosynthetic processGO:00015169.8PTGES2, EDN2
4regulation of vasoconstrictionGO:00192299.7EDN2, KCNA5
5cholesterol homeostasisGO:00426329.2FABP3, APOA4

Products for genes affiliated with Patent Ductus Arteriosus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Patent Ductus Arteriosus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet