PAD
MCID: PTN002
MIFTS: 65

Patent Ductus Arteriosus (PAD) malady

Cardiovascular diseases, Fetal diseases, Genetic diseases categories

Summaries for Patent Ductus Arteriosus

About this section
Sources:
63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Patent ductus arteriosus (PDA) is a congenital disorder in the heart wherein a neonate\'s ductus... more...

MalaCards: Patent Ductus Arteriosus, also known as patent ductus arteriosus, susceptibility to, is related to hypertension and breast cancer, and has symptoms including antenatal exposure : rubella, prematurity and terminal broadening/clubbing of toes. An important gene associated with Patent Ductus Arteriosus is PDA1 (Patent ductus arteriosus, susceptibility to), and among its related pathways is Prostanoid ligand receptors. The compounds homocysteine and prostaglandin e2 have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Description from OMIM:46 607411

Aliases & Classifications for Patent Ductus Arteriosus

About this section
Sources:
8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM, 39NCIt, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases, Genetic diseases
Anatomical: Cardiovascular diseases


Characteristics (Orphanet epidemiological data):

48
patent ductus arteriosus:
Inheritance: Autosomal dominant,Autosomal recessive,Multigenic/multifactorial; Prevalence: 1-5/10000; Age of onset: Neonatal/infancy; Age of death: Normal


Aliases & Descriptions:

patent ductus arteriosus 8 42 46 10 48
patent ductus arteriosus, susceptibility to 9
patent ductus arteriosus - persisting type 8
persistent patency of the arterial duct 48
patent ductus arteriosus familial 42
patency of the ductus arteriosus 42
ductus arteriosus patent 44
patent ductus botalli 8
patent arterial duct 48
pad mass 60
pda1 42
pad 48
pda 42


External Ids:

Disease Ontology8 DOID:13832
MeSH34 D004374
ICD9CM27 747.0
NCIt39 C84492
OMIM46 607411
ICD10 via Orphanet26 Q25.0
SNOMED-CT via Orphanet57 83330001
ICD1025 Q25.0

Related Diseases for Patent Ductus Arteriosus

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Patent Ductus Arteriosus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 258)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.3KCNA5, NPPB, CYP11B1
2breast cancer30.0FOLR1, FABP3, SHMT1, TRADD, PTGER1, PTGER2
3ventricular septal defect10.9
4char syndrome10.8
5endocarditis10.7
6cerebritis10.7
7subacute bacterial endocarditis10.6
8aortic aneurysm10.6
9thrombocytopenia10.6
10dissecting aortic aneurysm10.5
11thoracic aortic aneurysm10.5
12tetralogy of fallot10.5
13adult syndrome10.5
14esophagitis10.5
15intestinal perforation10.5
16patent ductus arteriosus - bicuspid aortic valve - hand anomalies10.5
17biliary atresia10.4
18coronary aneurysm10.4
19brachydactyly10.4
20atrioventricular septal defect10.4
21scimitar syndrome10.4
22aortic incompetence10.4
23atrial heart septal defect10.4
24heart septal defect10.4
25intestinal obstruction10.4
26intestinal pseudo-obstruction10.4
27pulmonary embolism10.4
28holt-oram syndrome10.4
29cantu syndrome10.4
30gorlin chaudhry moss syndrome10.4
31natal teeth, intestinal pseudoobstruction and patent ductus10.4
32thanatophoric dysplasia type 110.4
33congenital patent ductus arteriosus aneurysm10.4
34pulmonary artery coming from patent ductus arteriosus10.4
35peripheral vascular disease10.4
36hand-foot-genital syndrome10.3
37dermatitis10.3
38bart-pumphrey syndrome10.3
39oral submucous fibrosis10.3
40thrombocytopenia-absent radius syndrome10.2
41smith-lemli-opitz syndrome10.2
42ebstein anomaly10.2
43primary hypertrophic osteoarthropathy10.2
44marfan syndrome10.2
45rubella10.2
46retinopathy of prematurity10.2
47subclavian steal syndrome10.2
48mitral valve prolapse10.2
49klippel-trenaunay syndrome10.2
50hajdu-cheney syndrome10.2

Graphical network of the top 20 diseases related to Patent Ductus Arteriosus:



Diseases related to patent ductus arteriosus

Clinical Features for Patent Ductus Arteriosus

About this section
Sources:
46OMIM, 48Orphanet
See all sources

Clinical features from OMIM:

607411

Symptoms:

48 (show all 20)
  • antenatal exposure : rubella
  • prematurity
  • terminal broadening/clubbing of toes
  • high forehead
  • tetralogy of fallot/trilogy of fallot
  • flat face
  • pulmonary hypertension
  • respiratory rhythm disorder
  • failure to thrive/difficulties for feeding in infancy/growth delay
  • apnea/sleep apnea
  • autosomal dominant inheritance
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • repeat respiratory infections
  • broad nose/nasal bridge
  • short/small nose
  • asthenia/fatigue/weakness
  • cardiac rhythm disorder/arrhythmia
  • heart/cardiac failure
  • patent ductus arteriosus
  • autosomal recessive inheritance

Drugs & Therapeutics for Patent Ductus Arteriosus

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Patent Ductus Arteriosus

Drug clinical trials:

Search ClinicalTrials for Patent Ductus Arteriosus

Search NIH Clinical Center for Patent Ductus Arteriosus

Search CenterWatch for Patent Ductus Arteriosus

Genetic Tests for Patent Ductus Arteriosus

About this section

Anatomical Context for Patent Ductus Arteriosus

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Patent Ductus Arteriosus:

32
Heart, Lung, Brain, Testes, Smooth muscle, Liver, Eye

Animal Models for Patent Ductus Arteriosus or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Patent Ductus Arteriosus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538510.7ZIC3, NPPB, FABP3, TFAP2B, CYP11B1, PTGER1
2MP:000537610.5PTGES2, KCNA5, FOLR1, FABP3, TFAP2B, SHMT1

Publications for Patent Ductus Arteriosus

About this section
Sources:
50PubMed
See all sources

Articles related to Patent Ductus Arteriosus:

(show top 50)    (show all 581)
idTitleAuthorsYear
1
Correlation Analysis between Echocardiographic flow Pattern and N-terminal-pro-Brain natriuretic Peptide for early targeted Treatment of Patent Ductus Arteriosus. (24397409)
2014
2
Patent ductus arteriosus detected on 64-multidetector row CT. (23370756)
2013
3
Patent ductus arteriosus in an adult amur leopard (Panthera pardus orientalis). (23505729)
2013
4
Is paracetamol a useful treatment for ibuprofen-resistant patent ductus arteriosus?. Concerning the article by M.Y. Oncel et al: intravenous paracetamol treatment in the management of patent ductus arteriosus in extremely low birth weight infants [Neonatology 2013;103:166-169]. (23921529)
2013
5
Perinatal factors in patent ductus arteriosus in very low-birthweight infants. (23937654)
2013
6
Extrinsic bronchial compression due to patent ductus arteriosus closure device. (23706465)
2013
7
Eisenmenger syndrome in an adult patient with a large patent ductus arteriosus. (24293472)
2013
8
A clinical prediction model to estimate the risk for coarctation of the aorta in the presence of a patent ductus arteriosus. (24070640)
2013
9
Percutaneous closure of a gigantic patent ductus arteriosus (PDA) with pulmonary hypertension with an atrial septal defect occluder in a 35-year-old woman. (24356938)
2013
10
Outcomes following neonatal patent ductus arteriosus ligation done by pediatric surgeons: a retrospective cohort analysis. (23701759)
2013
11
Effects of indomethacin on patent ductus arteriosus in neonates with genetic disorders and/or congenital anomalies. (23147082)
2013
12
Patent ductus arteriosus: time to grasp the nettle? (22375021)
2013
13
Analyzing the failures of percutaneous closure of the patent ductus arteriosus in patients over 5 kg. (22954562)
2012
14
Stenting the patent ductus arteriosus in duct-dependent pulmonary circulation: techniques, complications and follow-up issues. (22413983)
2012
15
Genetics of patent ductus arteriosus susceptibility and treatment. (22414880)
2012
16
Cardiovascular instability after patent ductus arteriosus ligation in preterm infants: the role of hydrocortisone. (22094490)
2012
17
Quantification of left-to-right shunt through patent ductus arteriosus by colour Doppler in children admitted for a device closure. (21740609)
2012
18
Outcomes following the surgical ligation of the patent ductus arteriosus in premature infants in Scotland. (21852255)
2012
19
An unusual morphology of patent ductus arteriosus in a dog. (22489710)
2012
20
Patent ductus arteriosus in infants <29 weeks gestation--outcomes and factors affecting closure. (22317982)
2012
21
Cerebral autoregulation in neonates with a hemodynamically significant patent ductus arteriosus. (22226574)
2012
22
Aneurysm of the left atrium in a child with patent ductus arteriosus and mitral valve prolapse. (23288195)
2012
23
Patent ductus arteriosus clipping through an extrapleural approach in preterm infants with pulmonary hypertension. (21769522)
2012
24
New minimally invasive technique of perpulmonary device closure of patent ductus arteriosus through a parasternal approach. (22300626)
2012
25
Effect of persistent patent ductus arteriosus on mortality and morbidity in very low-birthweight infants. (22133090)
2012
26
Cerebral oxygenation during different treatment strategies for a patent ductus arteriosus. (21701212)
2011
27
Percutaneous closure of patent ductus arteriosus in children: Immediate and short-term changes in left ventricular systolic and diastolic function. (21976873)
2011
28
Dynamic volume 320-slice CT in the assessment of patent ductus arteriosus for percutaneous closure. (20194213)
2010
29
Interrupted aortic arch diagnosed with loss of femoral pulse in a patient undergoing patent ductus arteriosus ligation -A case report-. (20532057)
2010
30
Multisite infective endocarditis/endarteritis in a young peripartum patient with patent ductus arteriosus and rheumatic heart valve disease: a case report. (20529109)
2010
31
Patent ductus arteriosus ligation and post-operative hemodynamic instability: case report and framework for enhanced neonatal care. (20740386)
2010
32
Adult patent ductus arteriosus closure with a pedicled pulmonary arterial patch. (20732479)
2010
33
Closure of a large patent ductus arteriosus in children and adults with pulmonary hypertension. (20118039)
2010
34
Patent ductus arteriosus management: what are the next steps? (20580017)
2010
35
Patent ductus arteriosus closure in prematurities weighing less than 1 kg by subaxillary mini-thoracotomy. (20052343)
2010
36
B-type natriuretic peptide predicts responses to indomethacin in premature neonates with patent ductus arteriosus. (20227723)
2010
37
Surgical ligation of patent ductus arteriosus in premature infants. (20515605)
2010
38
Simultaneous transcatheter closure of intralobar pulmonary sequestration and patent ductus arteriosus in an infant. (19937013)
2010
39
Transcatheter closure of patent ductus arteriosus using the amplatzer duct occluder in infants under 1 year of age. (19706242)
2009
40
Right aortic arch and isolated left innominate artery from a left sided patent ductus arteriosus: a very rare aortic arch anomaly. (19361621)
2009
41
Patent ductus arteriosus and effects of low oxygen saturation limits. (19638991)
2009
42
Role of echocardiography on the evaluation of patent ductus arteriosus in newborns. (19757330)
2009
43
Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus. (16444274)
2006
44
Cor triatriatum associated with severe valvular pulmonary stenosis and patent ductus arteriosus: an unreported constellation. (16289372)
2006
45
Noninvasive diagnosis of aortic coarctation in neonates with patent ductus arteriosus. (16492432)
2006
46
Congenital sternal cleft with patent ductus arteriosus: report of a case. (11871821)
2002
47
Percutaneous catheter-based treatment of pulmonic stenosis and patent ductus arteriosus in a dog. (19081349)
2002
48
Right aortic arch with isolation of the left subclavian artery, moderate patent ductus arteriosus, and subclavian steal syndrome: A rare aortic arch anomaly treated with the Gianturco-Grifka vascular occlusion device. (10402288)
1999
49
Char syndrome (unusual mouth, patent ductus arteriosus, phalangeal anomalies). (1342853)
1992
50
Dextrocardia with Patent Ductus Arteriosus and Transposition of Viscera. (19989047)
1932

Genetic Variations for Patent Ductus Arteriosus

About this section

Expression for genes affiliated with Patent Ductus Arteriosus

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Patent Ductus Arteriosus

Search GEO for disease gene expression data for Patent Ductus Arteriosus.

Pathways for genes affiliated with Patent Ductus Arteriosus

About this section
Sources:
53Reactome, 37NCBI BioSystems Database
See all sources

Pathways related to Patent Ductus Arteriosus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5PTGER2, PTGER1

Compounds for genes affiliated with Patent Ductus Arteriosus

About this section
Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB
See all sources

Compounds related to Patent Ductus Arteriosus according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1homocysteine44 2412.0APOC2, NPPB, FOLR1, SHMT1
2prostaglandin e259 2412.0PTGES2, PTGER2, PTGER1
316, 16-dimethyl pge-24411.0PTGER2, PTGER1
4dihydrofolate4410.9FOLR1, GART, SHMT1
5gr 63799x4410.9PTGER1, PTGER2
6ah68092810.9PTGER1, PTGER2
717-phenyl-trinor-pge24410.9PTGER1, PTGER2
8bw245c4410.9PTGER1, PTGER2
9ah 68094410.9PTGER1, PTGER2
10thallium4410.9NPPB, FABP3
11lometrexol4410.9FOLR1, GART
12m&b 287672810.9PTGER1, PTGER2
13[3h]pge22810.9PTGER1, PTGER2
14pgd22810.9PTGER1, PTGER2
15ah2384844 2811.9PTGER1, PTGER2
16Alprostadil1110.9PTGER1, PTGER2
17enprostil28 4411.9PTGER1, PTGER2
18pgf2810.9PTGER1, PTGER2
19l-161,9825910.9PTGER1, PTGER2
20l-798,10659 2811.9PTGER1, PTGER2
21butaprost4410.9PTGER2, PTGER1
22u 466195910.9PTGER2, PTGER1
23-, methyl ester4410.8PTGER2, PTGER1
2411-deoxy-pge14410.8PTGER2, PTGER1
25pge22810.8PTGER1, PTGER2
26u4661928 4411.8PTGER1, PTGER2
27bupivacaine44 28 1112.8KCNA5, PTGER1
28sulprostone44 2811.8PTGER1, PTGER2
29misoprostol44 1111.8PTGER2, PTGER1
30tomudex4410.8FOLR1, GART
31thymidylate4410.7FOLR1, GART, SHMT1
32carbacyclin44 2811.7PTGER2, PTGER1
33Tetrahydrofolic acid11 2411.7SHMT1, GART
34mibg4410.6FABP3, NPPB
35aldosterone28 11 2412.6NPPB, CYP11B1
36forskolin44 49 1112.5CYP11B1, NPPB
37pge24410.5PTGES2
38Dinoprostone1110.4PTGER2, PTGER1
39arachidonic acid44 28 11 2413.3FABP3, PTGER1, PTGER2, PTGES2

GO Terms for genes affiliated with Patent Ductus Arteriosus

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Patent Ductus Arteriosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of urine volumeGO:03581010.5TFAP2B, NPPB
2purine nucleobase biosynthetic processGO:00911310.5SHMT1, GART
3potassium ion homeostasisGO:05507510.4TFAP2B, KCNA5
4folic acid metabolic processGO:04665510.2SHMT1, FOLR1

Molecular functions related to Patent Ductus Arteriosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipid bindingGO:00828910.6FABP3, APOC2, BPIFA1
2prostaglandin E receptor activityGO:00495710.2PTGER2, PTGER1

Products for genes affiliated with Patent Ductus Arteriosus

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Patent Ductus Arteriosus

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet