Patent Ductus Arteriosus malady

Wikipedia: Patent ductus arteriosus (PDA) is a congenital disorder in the heart wherein a neonate\'s ductus...⁴⁴ more...

MalaCards: Patent Ductus Arteriosus, also known as patent ductus arteriosus - persisting type, is related to familial thoracic aortic aneurysm and dissection and thoracic aortic aneurysm. An important gene associated with Patent Ductus Arteriosus is PDA1 (Patent ductus arteriosus, susceptibility to), and among its related pathways are Bacterial infections in CF airways and Antimetabolite Pathway - Folate Cycle, Pharmacodynamics. The compounds cyclophosphamide and nadph have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and fetal lung, and related mouse phenotypes are mortality/aging and cardiovascular system.

Aliases & Descriptions:

patent ductus arteriosus 6 30 8 patent ductus arteriosus - persisting type 6 patent ductus arteriosus familial (type) 30 patent ductus arteriosus (disorder) 6 patency of the ductus arteriosus 30

ductus arteriosus patent 32 patent ductus botalli 6 pda1 30 pda 30

Diseases related to patent ductus arteriosus by text searches and GeneDecks gene sharing:

(show top 50)    (show all 877)

id	Related Disease	Score	Top Affiliating Genes
1	familial thoracic aortic aneurysm and dissection	32.9	COL3A1, TGFBR1, TGFBR2, MYH11
2	thoracic aortic aneurysm	32.9	MMP9, TNF, COL3A1, TGFBR1, TGFBR2, MYH11
3	ventricular septal defect	32.1	VEGFA, ZIC3, IGF1, EVC, TBX1, TBX5
4	rheumatoid arthritis	29.1	IL1R2, IL1RN, MBL2, TNFRSF1A
5	crohn's disease	24.2	MPO, IL10, IL1B, IL1RN, IL4, IL6
6	aortic aneurysm	24.0	VEGFA, MTRR, MTHFR, MTR, MTHFD1, CETP
7	cerebral infarction	20.3	VEGFA, LPL, LIPC, LDLR, LCAT, MTHFR
8	neural tube defect	13.9	ZIC3, MTRR, MTHFR, MTR, MTHFD1, SHMT1
9	anencephaly	13.9	MTRR, MTHFR, MTR, MTHFD1, FOLR1
10	congenital heart defect	13.9	ZIC3, MTR, PTPN11, TBX5, EDN1, NPPB
11	folic acid deficiency anemia	13.8	MTHFR, MTR, FOLR1, DHFR, SLC19A1
12	hereditary diffuse leukoencephalopathy with spheroids	13.8	LCAT, CETP, APOA1, APOB, ABCA1
13	homocysteinemia	13.8	MTRR, MTHFR, MTR, F5, SLC19A1
14	21-hydroxylase deficiency	13.8	HSD3B1, CYP11A1, CYP11B1, CYP17A1, NR3C1
15	adrenal adenoma	13.8	LDLR, IGF2, HSD11B2, HSD11B1, CYP11A1, CYP11B1
16	autoimmune polyendocrine syndrome type 1	13.8	DDC, CYP1A2, CYP11A1, CYP17A1
17	thiamine-responsive megaloblastic anemia syndrome	13.7	MTRR, MTHFR, MTR, HP
18	homocysteine plasma level	13.7	MTRR, MTHFR, MTR, F5, NNMT, EDN1
19	arcus senilis	13.7	LCAT, APOA1, APOB
20	birth defects	13.7	MTRR, MTHFR, MTR, MTHFD1, CYP1A2, CYP2E1
21	lung benign neoplasm	13.7	SFTPB, SFTPD, PTGIS, DDC, CYP1A1, NQO1
22	drug-induced hepatitis	13.7	NAT2, GSTT1, CYP2C19, CYP2E1, CYP2D6, CYP2C9
23	lipid metabolism disorder	13.7	LPL, APOA1, APOB, HLA-G
24	respiratory failure	13.6	SFTPB, SFTPD, PTGS1, ADRB2, EPHX1
25	bleeding diathesis due to gnaq deficiency	13.6	GP1BA, GP6, F5, F2, F13A1
26	combined hyperlipemia	13.6	LPL, LIPC, APOA1, APOB
27	hyperlipoproteinemia type v	13.6	LPL, APOC2, APOE
28	myelomeningocele	13.6	MTRR, MTHFR, MTR, MTHFD1, IGF1
29	cardia cancer	13.6	MTRR, MTHFR, GSTT1, CYP1A1, CYP2E1
30	cherubism	13.6	LPL, LDLR, LCAT, CETP, APOB
31	lipoprotein glomerulopathy	13.6	LDLR, LCAT, APOB, APOE
32	alcoholic pancreatitis	13.6	NAT2, LPL, GSTT1, ALDH2, CYP2E1, NQO1
33	orofacial cleft	13.6	NAT2, MTRR, MTHFR, MTR, MTHFD1, GSTT1
34	familial prostate cancer	13.6	GSTT1, HSD3B1, AKR1C3, ESR1, CYP1A1, CYP1A2
35	hepatic lipase deficiency	13.6	LPL, LIPC, LCAT, APOA1, APOE
36	familial hypertriglyceridemia	13.6	LPL, APOA1, APOA5, APOB, APOC3, APOE
37	familial combined hyperlipidemia	13.6	APOA1, APOB, APOE, HMGCR
38	abetalipoproteinemia	13.5	LDLR, LCAT, APOA1, APOB, APOC2, APOE
39	smith-lemli-opitz syndrome	13.5	LDLR, APOE, HMGCR, CYP11A1, DHCR7
40	pediatric osteosarcoma	13.5	MTHFR, MTR, FOLR1, FAS, IGF1, SHMT1
41	norum disease	13.5	LPL, LCAT, APOA1, APOB, APOE
42	nasopharynx carcinoma	13.5	NAT2, BPIFA1, FOLR1, GSTT1, HLA-B, CYP1A1
43	allergic bronchopulmonary aspergillosis	13.5	SFTPD, IL4, IL5, MBL2
44	cushing's syndrome	13.5	SERPINA6, LPL, IGF1, HSD11B2, HSD3B1, HSD11B1
45	mayer-rokitansky-kuster-hauser syndrome	13.5	SFTPB, LPL, LDLR, LCAT, MTR, APOB
46	aplastic anemia	13.5	GSTT1, FAS, GP1BA, IFNG, CYP2D6, NQO1
47	hypospadias	13.5	ZEB2, GSTT1, HSD3B1, ESR1, CYP1A1, CYP11A1
48	defective apolipoprotein b-100	13.5	LDLR, LCAT, APOB, APOE, HMGCR
49	hodgkin's lymphoma	13.5	BIRC2, BIRC3, IL1RN, HLA-B, TRAF1, TRAF2
50	peripheral vascular disease	13.5	CETP, APOA1, APOB, HMGCR

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to patent ductus arteriosus:

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MGI Mouse Phenotypes related to patent ductus arteriosus:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	mortality/aging	MP:0010768	INF	HMGCR, IL6, IL1B, FOLR1, ITGB3, CFH
2	cardiovascular system phenotype	MP:0005385	INF	LCAT, LDLR, CHD7, KCNA5, , BIRC3
3	embryogenesis phenotype	MP:0005380	INF	, PGR, SLC19A1, TBX5, TBX1, PTPN11
4	growth/size phenotype	MP:0005378	INF	FAS, CHD7, ZEB2, , BIRC2, LPL
5	respiratory system phenotype	MP:0005388	INF	PTGER4, F13A1, APOE, ITGB3, CHD7, KCNN3
6	liver/biliary system phenotype	MP:0005370	INF	SERPINA6, TNFAIP3, HSD11B1, IFNG, APOB, APOA1
7	endocrine/exocrine gland phenotype	MP:0005379	10.2	SLC19A1, OXTR, CRHR1, CYP11B1, CYP1A2, TBX1
8	renal/urinary system phenotype	MP:0005367	9.7	DDC, SERPINA6, LCAT, CFH, PTGS1, PTGER1
9	no phenotypic analysis	MP:0003012	9.1	PTGER2, PTGS2, PTPN11, TBX1, CYP1A1, CYP1A2
10	other phenotype	MP:0005395	9.0	NOS2, PLA2G4A, PTGS1, PTGS2, PTGER2, TNFRSF1A
11	integument phenotype	MP:0010771	8.1	PTPN11, FAS, IL4, ITGB3, ITGA2, LDLR
12	behavior/neurological phenotype	MP:0005386	7.1	GABBR2, ADRB2, PGR, OXTR, OXT, CYP1A2
13	adipose tissue phenotype	MP:0005375	6.5	PTGS2, PTPN11, CYP11B1, NR3C1, NQO1, NOS2
14	tumorigenesis	MP:0002006	4.8	EPHX1, CYP1A2, PTPN11, PTGS1, PTGER4, PTGER1
15	limbs/digits/tail phenotype	MP:0005371	INF	ESR1, TNFRSF1A, TBX1, TBX5, TLR4, TFAP2B
16	digestive/alimentary phenotype	MP:0005381	INF	MYH11, EP300, SLC19A1, OXT, DHCR7, TGFBR2
17	reproductive system phenotype	MP:0005389	INF	, LIPC, VEGFA, ZEB2, OXTR, OXT
18	muscle phenotype	MP:0005369	INF	BIRC2, LPL, VEGFA, MYH11, TLR4, ABCA1
19	skeleton phenotype	MP:0005390	INF	PGR, TGFBR2, TGFBR1, NR3C1, DARC, TBX5
20	cellular phenotype	MP:0005384	INF	TLR4, ABCA1, NOS2, PLA2G4A, NQO1, NR3C1
21	hematopoietic system phenotype	MP:0005397	INF	SLC19A1, NQO1, TBX1, PTGER4, PTGER1, BIRC3
22	vision/eye phenotype	MP:0005391	INF	PTEN, TNFRSF1B, TNFRSF1A, TNF, IFNG, IGF2
23	immune system phenotype	MP:0005387	INF	EP300, ADRB2, SLC19A1, TLR4, ABCA1, PLA2G4A
24	normal phenotype	MP:0002873	INF	CYP1A1, TBX5, TBX1, PTPN11, PTGER4, PTGS2
25	nervous system phenotype	MP:0003631	INF	DDC, TBX1, PTPN11, PTGER1, PTGER2, CYP11B1
26	craniofacial phenotype	MP:0005382	INF	SLC24A5, DHCR7, EDN1, TBX1, PTPN11, EVC
27	homeostasis/metabolism phenotype	MP:0005376	INF	GABBR2, EPHX1, EP300, ADRB2, PGR, SLC19A1

Articles related to patent ductus arteriosus:

(show all 17)

id	Title	Authors	Year	Affiliating Genes
1	Determination of genetic predisposition to patent ductus arteriosus in preterm infants. (19336370)	Dagle J.M.... Murray J.C.	2009	TGFBR2, ALDH2, TGFBR1
2	B-type natriuretic peptide concentrations to guide treatment of patent ductus arteriosus. (18981033)	Attridge J.T.... Lim D.S.	2009	NPPB
3	Pharmacological closure of patent ductus arteriosus: effects on pulse pressure and on endothelin-1 and vasopressin excretion. (18509786)	Zanardo V.... Trevisanuto D.	2008	EDN1
4	N-terminal pro-B-type natriuretic peptide: a measure of significant patent ductus arteriosus. (18218660)	Farombi-Oghuvbu I.... Corcoran J.D.	2008	NPPB
5	Novel TFAP2B mutation in nonsyndromic patent ductus arteriosus. (18752453)	Khetyar M.... Carter N.	2008	TFAP2B
6	Maternal and offspring MTHFR gene C677T polymorphism as predictors of congenital atrial septal defect and patent ductus arteriosus. (16373366)	Zhu W.L.... Li S.	2006	MTHFR
7	Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus. (16444274)	Zhu L.... Jeunemaitre X.	2006	MYH11
8	Urinary ET-1, AVP and sodium in premature infants treated with indomethacin and ibuprofen for patent ductus arteriosus. (16133044)	Zanardo V.... Plebani M.	2005	EDN1
9	Utility of rapid B-type natriuretic peptide assay for diagnosis of symptomatic patent ductus arteriosus in preterm infants. (15687418)	Choi B.M.... Lee J.W.	2005	NPPB
10	Role of plasma B-type natriuretic peptide in screening for hemodynamically significant patent ductus arteriosus in preterm neonates. (16222347)	Sanjeev S.... L'Ecuyer T.	2005	NPPB
11	The use of a bedside assay for plasma B-type natriuretic peptide as a biomarker in the management of patent ductus arteriosus in premature neonates. (16027692)	Flynn P.A.... Kleinman C.S.	2005	NPPB
12	Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus. (15353504)	Thebaud B.... Archer S.L.	2004	KCNA5, KCNB1
13	Familial thoracic aortic aneurysm/dissection with patent ductus arteriosus: genetic arguments for a particular pathophysiological entity. (14722581)	Khau Van Kien P.... Jeunemaitre X.	2004	COL3A1
14	Conservative treatment of hemolytic complication following coil embolization in two adult cases of patent ductus arteriosus. (11548885)	Eda K.... Yamaguchi I.	2001	HP
15	Molecular determinants of atrial and ventricular septal defects and patent ductus arteriosus. (11376442)	Vaughan C.J.... Basson C.T.	2000	EVC
16	Mutations in TFAP2B cause Char syndrome, a familial form of patent ductus arteriosus. (10802654)	Satoda M.... Gelb B.D.	2000	TFAP2B
17	Closure of patent ductus arteriosus decreases pulmonary myeloperoxidase in premature infants with respiratory distress syndrome. (7640315)	Varsila E.... Andersson S.	1995	MPO

Genes related to patent ductus arteriosus according to GeneCards:

(show top 50)    (show all 139)

id	Symbol	Description	Score	GeneCards Section Context
1	PDA1	Patent ductus arteriosus, susceptibility to	11.1	Aliases & Descriptions
2	SLC24A5	solute carrier family 24, member 5	11.0	Publications
3	RPAIN	RPA interacting protein	11.0	Publications
4	PTGES2	prostaglandin E synthase 2	11.0	Publications
5	BPIFA1	BPI fold containing family A, member 1	11.0	Publications
6	TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	11.0	Publications
7	NNMT	nicotinamide N-methyltransferase	11.0	Publications
8	EDN2	endothelin 2	11.0	Publications
9	HPGD	hydroxyprostaglandin dehydrogenase 15-(NAD)	11.0	Publications
10	HSD3B1	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	11.0	Publications
11	KCNA5	potassium voltage-gated channel, shaker-related subfamily, member 5	11.0	Publications
12	IL10RA	interleukin 10 receptor, alpha	11.0	Publications
13	SHMT1	serine hydroxymethyltransferase 1 (soluble)	11.0	Publications
14	DARC	Duffy blood group, chemokine receptor	11.0	Publications
15	DEFB1	defensin, beta 1	11.0	Publications
16	DHCR24	24-dehydrocholesterol reductase	11.0	Publications
17	IL1R2	interleukin 1 receptor, type II	11.0	Publications
18	GART	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	11.0	Publications
19	PTGES	prostaglandin E synthase	11.0	Publications
20	FMO1	flavin containing monooxygenase 1	11.0	Publications
21	FMO3	flavin containing monooxygenase 3	11.0	Publications
22	FOLR1	folate receptor 1 (adult)	11.0	Publications
23	PTGER1	prostaglandin E receptor 1 (subtype EP1), 42kDa	11.0	Publications
24	TBX1	T-box 1	11.0	Publications
25	ABCC11	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	11.0	Publications
26	APOC2	apolipoprotein C-II	11.0	Publications
27	DHCR7	7-dehydrocholesterol reductase	11.0	Publications
28	TRADD	TNFRSF1A-associated via death domain	11.0	Publications
29	HSD11B2	hydroxysteroid (11-beta) dehydrogenase 2	11.0	Publications
30	ZEB2	zinc finger E-box binding homeobox 2	11.0	Publications
31	OXTR	oxytocin receptor	11.0	Publications
32	KCNB1	potassium voltage-gated channel, Shab-related subfamily, member 1	11.0	Publications
33	TNFAIP3	tumor necrosis factor, alpha-induced protein 3	11.0	Publications
34	APOA5	apolipoprotein A-V	11.0	Publications
35	APOA4	apolipoprotein A-IV	11.0	Publications
36	GP1BA	glycoprotein Ib (platelet), alpha polypeptide	11.0	Publications
37	MTHFD1	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	11.0	Publications
38	SFTPB	surfactant protein B	11.0	Publications
39	TRAF1	TNF receptor-associated factor 1	11.0	Publications
40	MTRR	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	11.0	Publications
41	GP6	glycoprotein VI (platelet)	11.0	Publications
42	EVC	Ellis van Creveld syndrome	11.0	Publications
43	PTGER2	prostaglandin E receptor 2 (subtype EP2), 53kDa	11.0	Publications
44	TBX5	T-box 5	11.0	Publications
45	SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	11.0	Publications
46	COL3A1	collagen, type III, alpha 1	11.0	Publications
47	CHRNA4	cholinergic receptor, nicotinic, alpha 4 (neuronal)	11.0	Publications
48	PTGIS	prostaglandin I2 (prostacyclin) synthase	11.0	Publications
49	SLC19A1	solute carrier family 19 (folate transporter), member 1	11.0	Publications
50	PTGFR	prostaglandin F receptor (FP)	11.0	Publications

Pathways related to patent ductus arteriosus according to GeneDecks:

(show top 50)    (show all 142)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways41	10.8	SFTPD
2	Antimetabolite Pathway - Folate Cycle, Pharmacodynamics34	10.7	MTRR, MTHFD1, MTR, MTHFR, GART, SHMT1
3	Methotrexate Pathway (Cancer Cell), Pharmacodynamics34	10.7	SLC19A1, MTHFR, MTR, MTHFD1, SHMT1, DHFR
4	Phenytoin Pathway, Pharmacokinetics34	10.5	EPHX1, CYP2C9, CYP2D6, CYP1A2, CYP2E1, PTGIS
5	Apoptosis and Autophagy3	10.4	TFAP2B, NQO1, PTPN11, TNFRSF1B, TNFRSF1A, TNFAIP3
6	Prostaglandin 2 biosynthesis and metabolism FM41	10.4	PTGES2, PTGS2, PTGIS, PTGES, AKR1C3, HPGD
7	Prostaglandin 2 biosynthesis and metabolism FM10	10.4	PTGS2, PTGIS, PTGES, PTGES2, AKR1C3, HPGD
8	Graft-versus-host disease20	10.3	HLA-G, IL1A, HLA-B
9	Arachidonic acid metabolism20	10.2	CYP2C19, AKR1C3, PTGES, PTGIS, PTGES2, PTGS1
10	Naphthalene metabolism41	10.2	CYP2E1, CYP2C9, GSTT1, EPHX1, CYP1A2, CYP1A1
11	Naphthalene metabolism10	10.2	AKR1C3, CYP1A1, CYP1A2, CYP2E1, CYP2C9, EPHX1
12	Statin Pathway, Pharmacodynamics34	10.0	APOA5, LPL, HMGCR, LIPC, LDLR, LCAT
13	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics34	9.8	ITGA2, GP6, F2, PTGER2, PTGS1, PLA2G4A
14	Molecular Mechanisms of Cancer36	9.6	BIRC3, BIRC2, EP300, ITGA2, IL10RA, IL5
15	Celecoxib Pathway, Pharmacodynamics34	9.6	PTGIS, PTGS2, PTGS1, PTGER1, PTGER4, PLA2G4A
16	Apoptotic Pathways Triggered By HIV136	9.5	TNFRSF1B, TNFRSF1A, TRADD, TNF, TRAF2, TRAF1
17	TRAF Pathway36	9.4	TRADD, TRAF2, IL1B, TRAF1, IL1A, BIRC3
18	Metabolism of lipids and lipoproteins38	9.4	HSD3B1, DHCR24, HSD11B1, PTGIS, PTGS2, APOE
19	Amoebiasis20	9.3	IL8, IL1R2, IL1B, NOS2, IL6, COL3A1
20	Metabolic pathways20	9.1	CYP11A1, CYP1A2, GART, DHFR, DHCR7, PTGS1
21	NF-kappaB Signaling3	9.0	NQO1, PTGS1, TLR4, PTGS2, TNFRSF1B, TRAF1
22	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.9	TGFB1, IL4, IL6, TGFBR2, IL1B, IFNG
23	Pathways in cancer20	8.7	MMP9, FAS, TRAF1, EP300, NOS2, TGFB1
24	Hematopoietic cell lineage20	8.4	IL6, IL4, IL1R2, TNF, ITGA2, GP1BA
25	Glucocorticoid Receptor Signaling36	8.4	EP300, TGFBR1, TGFB1, NR3C1, IL4, TNFRSF1A
26	Toxoplasmosis20	8.3	TGFB1, LDLR, IL10, IL10RA, IFNG, TNFRSF1A
27	NF-KappaB (p50-p65) Pathway36	8.3	TLR4, TNFRSF1A, TNFAIP3, IL1B, TNFRSF1B, TRAF2
28	NF-KappaB Family Pathway36	8.3	TNFRSF1B, TRAF1, TRAF2, TRADD, TNF, TNFRSF1A
29	Malaria20	8.2	TGFB1, IL10, IL1B, IL6, IL8, IFNG
30	Allograft rejection20	8.2	TNF, IL10, IL4, IL5, IFNG, HLA-B
31	Tec Kinases Signaling36	8.2	IL4, TNFRSF1B, ITGB3, IL10, IL10RA, IL5
32	Immune response MIF-mediated glucocorticoid regulation10	8.1	MMP1, IFNG, TNF, IL8, PTGS2, NOS2
33	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	8.1	TGFBR1, NR3C1, TNF, IFNG, IL6, IGF1
34	Immune response_MIF-mediated glucocorticoid regulation41	8.1	NOS2, NR3C1, PTGS2, TNF, IFNG, IL6
35	Transcription Role of VDR in regulation of genes involved in osteoporosis10	8.0	TGFBR1, NR3C1, TNF, IFNG, IL1B, IGF1
36	Immune response MIF in innate immunity response10	8.0	IL1B, IL6, IL8, TNF, PTGS2, NOS2
37	Immune response_MIF in innate immunity response41	8.0	IL8, IFNG, TNF, PTGS2, NOS2, TLR4
38	TGF-Beta Pathway36	7.9	TGFBR1, TNFRSF1A, IGF1, IGF2, IL8, IL6
39	Cytokine Network36	7.9	TNF, IFNG, IL8, IL6, IL5, IL1B
40	Tuberculosis20	7.8	IL1A, TGFB1, TNFRSF1A, EP300, TLR4, NOS2
41	Rheumatoid arthritis20	7.7	TLR4, TGFB1, TNF, IFNG, IL8, IL6
42	Colorectal Cancer Metastasis36	7.7	PTGS2, MMP1, MMP9, IL6, IFNG, TNF
43	Chagas disease (American trypanosomiasis)20	7.6	FAS, IL8, IL1B, IFNG, IL6, IL10
44	MIF Mediated Glucocorticoid Regulation36	7.4	TLR4, IL10, IL1B, IL5, IL6, IL8
45	Leishmaniasis20	7.4	IL1A, IL1B, TLR4, TGFB1, TNF, IFNG
46	MAPK Family Pathway36	7.2	IL10, TNFRSF1B, IL10RA, IL1A, TGFB1, TGFBR2
47	p38 Signaling36	7.1	TRADD, IL6, IL8, IGF2, IGF1, TRAF2
48	Cytokine-cytokine receptor interaction20	7.0	VEGFA, IL1A, IL10RA, IL10, TGFBR2, TGFBR1
49	JAK-STAT Pathway36	7.0	IL8, IGF2, IGF1, TGFB1, F2, TNFRSF1A
50	Antioxidant Action of Vitamin-C36	6.4	PLA2G4A, IL5, MYH11, IL4, IL1B, IL1A

Compounds related to patent ductus arteriosus according to GeneDecks:

(show top 50)    (show all 606)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.8	MBL2, NPPB
2	nadph32 18	11.5	FMO1, FMO3, HSD11B1, CYP1A1, CYP2C19, CYP2E1
3	methionine32	10.3	LIPC, LCAT, MTHFD1, ITGA2, FOLR1, FMO3
4	polyethylene glycol32	9.9	MPO, FOLR1, APOA1, APOE, IGF2, HP
5	pravastatin32 34 9 18 9	13.7	LDLR, LCAT, CETP, IL6, APOA1, APOB
6	progesterone32 42 9 18 9	13.6	SFTPB, SERPINA6, HSD11B2, HSD3B1, HSD11B1, HPGD
7	mspi32	9.6	NAT2, LDLR, CETP, FOLR1, GSTT1, APOA1
8	gemfibrozil32 9 9	11.6	LPL, LIPC, LDLR, CETP, APOA1, APOB
9	probucol32 9 9	11.5	LPL, LIPC, LDLR, LCAT, CETP, APOA1
10	h2o232	9.1	KCNA5, KCNN3, LDLR, MPO, IL1RN, IL5
11	n acetylcysteine32	9.1	MMP1, MMP9, APOE, F2, HMGCR, TRAF2
12	acth32	9.0	SERPINA6, IL1A, IL1B, IL1RN, IL6, IGF2
13	nifedipine32 9 9	10.9	LDLR, MMP9, IL1A, APOA1, CYP1A1, CYP1A2
14	pioglitazone32 9 9	10.7	VEGFA, LPL, LIPC, MMP1, MMP9, APOA1
15	epinephrine32 9 18 9	11.6	ITGA2, MMP1, MMP9, IL1A, IL1RN, APOB
16	ritonavir32 34 9 9	11.6	LPL, LDLR, IL4, APOA1, APOA4, APOC3
17	dihydrotestosterone32 9 18 9	11.3	SERPINA6, LPL, IL4, FAS, IGF2, IGF1
18	fluvastatin32 34 9 9	11.2	LPL, LDLR, CETP, MMP1, MMP9, IL1A
19	fenofibrate32 9 9	10.2	LPL, LIPC, LDLR, CETP, MMP9, IL6
20	cysteine32	8.1	SFTPB, SFTPD, SERPINA6, NAT2, LDLR, LCAT
21	alanine32	8.0	SERPINA6, BIRC3, LDLR, LCAT, CFH, CETP
22	polyinosinic-polycytidylic acid32	8.0	IL10, IL4, IL5, IL6, IL8, IFNG
23	adenylate32	7.9	SERPINA6, LPL, LDLR, MMP9, IL1RN, IL4
24	prostaglandin32	7.8	MMP1, MMP9, IL1A, IL1B, IL1RN, IL6
25	tamoxifen32 34 9 9	10.7	SERPINA6, VEGFA, LPL, LDLR, CETP, FMO1
26	glutamine32	7.6	SFTPD, LPL, KCNN3, LDLR, LCAT, MTR
27	sb 20358032 42	8.6	VEGFA, BIRC2, BIRC3, MMP1, MMP9, IL6
28	alpha tocopherol32	7.4	LPL, LDLR, LCAT, MTHFR, CETP, MMP1
29	thalidomide32 42 9 9	10.4	VEGFA, BIRC2, BIRC3, IL10, IL1B, IL5
30	testosterone32 9 18 9	10.3	SERPINA6, LPL, LIPC, LCAT, MTHFR, CETP
31	polymyxin b32	7.3	LDLR, IL10, IL1A, IL1B, IL1RN, IL4
32	creatinine32	7.1	MTHFR, MTR, MPO, MMP1, MMP9, GSTT1
33	prostacyclin32	7.1	VEGFA, LDLR, IL10, IL1A, IL1B, APOA1
34	lipid32	7.1	SFTPB, SFTPD, SERPINA6, LPL, LIPC, BIRC3
35	atorvastatin32 34 9 18 9	11.0	VEGFA, LPL, LIPC, LDLR, LCAT, CETP
36	rosiglitazone32 9 18 9	10.0	LPL, MMP1, MMP9, IL1RN, IL4, IL6
37	il 1032	6.9	IL10, IL10RA, IL1A, IL1B, IL1RN, IL4
38	estrogen32	6.9	SERPINA6, NAT2, LPL, LIPC, LCAT, MTHFR
39	fluticasone propionate32 42 9 9	9.8	SERPINA6, MPO, MMP9, IL1B, IL4, IL5
40	thymidine32 18	7.6	SFTPB, SFTPD, MTHFR, IL10, IL1A, IL1B
41	pdtc32	6.4	SFTPB, BIRC3, MMP1, MMP9, IL1A, IL1B
42	ly29400232	6.3	VEGFA, BIRC2, BIRC3, MMP9, IL10, IL1B
43	lactate32	5.9	SFTPD, LPL, MPO, MMP1, MMP9, IL1RN
44	herbimycin a32 42	6.8	MMP1, MMP9, IL1A, IL1B, IL4, IL5
45	vegf32	5.8	SFTPB, BIRC2, MPO, ITGA2, ITGB3, MMP1
46	simvastatin32 34 42 9 18 9	10.4	VEGFA, LPL, LDLR, LCAT, CETP, MMP9
47	actinomycin d32	3.8	SFTPB, VEGFA, BIRC2, BIRC3, LDLR, MMP9
48	vitamin a32 9 18 9	INF	SFTPB, SERPINA6, NAT2, LPL, LIPC, LDLR
49	cholesterol32 9 18 9	INF	SFTPB, SFTPD, SERPINA6, NAT2, LPL, LIPC
50	retinoic acid32 42 18	INF	SFTPB, LDLR, MTHFR, CFH, CETP, MPO

Cellular components related to patent ductus arteriosus according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	chylomicron	GO:042627	10.2	APOE, APOC3, APOC2, APOB, APOA5, APOA4
2	very-low-density lipoprotein particle	GO:034361	10.1	APOE, APOC3, APOC2, APOB, APOA5, APOA4
3	high-density lipoprotein particle	GO:034364	10.1	APOE, APOA5, APOA4, APOA1, CETP, LCAT
4	intermediate-density lipoprotein particle	GO:034363	10.0	APOE, APOC3, APOC2, APOB
5	low-density lipoprotein particle	GO:034362	9.7	APOE, APOC2, APOB, APOA5, LDLR
6	endoplasmic reticulum membrane	GO:005789	9.3	CYP2E1, CYP2D6, CYP17A1, CYP2C9, PLA2G4A, DHCR24
7	external side of plasma membrane	GO:009897	8.1	TLR4, TNF, IFNG, FAS, IL4, ITGA2
8	plasma membrane	GO:005886	6.4	DARC, PTGS1, PTGFR, PTGER4, PTGER1, PTGER2
9	extracellular region	GO:005576	5.5	NPPB, SFTPD, IL1B, IL1R2, IL5, IL6
10	extracellular space	GO:005615	3.9	SFTPB, IL1A, IL1B, IL1RN, IL4, IL5

Biological processes related to patent ductus arteriosus according to GeneDecks:

(show top 50)    (show all 93)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	IFNG, TNFRSF1A, TBX1, ESR1, IGF1, IL6
2	glucocorticoid biosynthetic process	GO:006704	10.8	CYP11B1, HSD11B1, HSD3B1, CYP17A1, HSD11B2
3	folic acid metabolic process	GO:046655	10.7	SLC19A1, SHMT1, MTHFD1, MTHFR, FOLR1
4	steroid metabolic process	GO:008202	10.6	HSD3B1, HSD11B1, AKR1C3, CYP2E1, CYP2D6, CYP11A1
5	monoterpenoid metabolic process	GO:016098	10.5	CYP2D6, CYP1A2, CYP2E1, CYP2C19, CYP2C9
6	prostaglandin biosynthetic process	GO:001516	10.5	PTGS2, PTGES2, PTGES, EDN2, PTGIS, PTGS1
7	phospholipid efflux	GO:033700	10.5	APOA1, ABCA1, APOE, APOC3, APOC2, APOA4
8	triglyceride homeostasis	GO:070328	10.5	APOC3, CETP, APOC2, APOA5, LIPC, LPL
9	heart development	GO:007507	10.4	PTEN, NPPB, OXTR, OXT, TGFBR2, TGFBR1
10	drug metabolic process	GO:017144	10.4	CYP1A2, CYP2C19, CYP2C9, CYP2E1, CYP1A1, FMO3
11	cholesterol efflux	GO:033344	10.4	APOA1, APOA4, APOC2, APOC3, APOE, ABCA1
12	very-low-density lipoprotein particle remodeling	GO:034372	10.4	CETP, APOE, APOC2, APOA4, LIPC, LPL
13	high-density lipoprotein particle remodeling	GO:034375	10.4	LIPC, LCAT, APOA1, APOA4, APOC3, APOE
14	prostaglandin metabolic process	GO:006693	10.3	PTGS2, PTGES, TNFRSF1A, AKR1C3, HPGD
15	reverse cholesterol transport	GO:043691	10.3	APOA1, APOA4, APOC2, CETP, LCAT, APOC3
16	negative regulation of inflammatory response	GO:050728	10.3	ADRB2, PTGER4, PTGIS, TNFRSF1B, TNFRSF1A, APOE
17	Cdc42 protein signal transduction	GO:032488	10.3	APOE, APOA1, ABCA1, APOC3
18	cholesterol transport	GO:030301	10.3	APOB, LDLR, APOA1, LCAT, CETP
19	regulation of sensory perception of pain	GO:051930	10.2	OXT, ADRB2, IL10, EDN1, IL1A, TLR4
20	cholesterol homeostasis	GO:042632	10.1	APOC3, APOB, APOE, APOC2, APOA5, APOA4
21	receptor-mediated endocytosis	GO:006898	10.1	ADRB2, APOE, LDLR, APOB, FOLR1, CETP
22	oxidation-reduction process	GO:055114	10.1	CYP2C19, CYP1A2, CYP1A1, MPO, CYP2E1, AKR1C3
23	lipoprotein metabolic process	GO:042157	10.1	ABCA1, APOE, APOC2, APOB, APOA5, APOA4
24	triglyceride metabolic process	GO:006641	10.0	PTPN11, APOC3, APOA5, CETP, LPL, APOE
25	xenobiotic metabolic process	GO:006805	9.9	PTGS1, CYP1A1, CYP1A2, CYP2C19, CYP2E1, CYP2D6
26	lipid metabolic process	GO:006629	9.9	APOE, CETP, LPL, IL1RN, PTGS1, APOB
27	response to organic nitrogen	GO:010243	9.9	PLA2G4A, PTGS2, NNMT, IL1RN, IL1A, IL1B
28	female pregnancy	GO:007565	9.7	CRHR1, TGFB1, IL1RN, IL4, OXT, OXTR
29	regulation of cell proliferation	GO:042127	9.6	PTGS1, DHCR7, BIRC2, TGFBR2, PTGER2, NOS2
30	G-protein coupled receptor signaling pathway	GO:007186	9.5	PTGFR, PTGER2, EDN1, AKR1C3, APOE, APOA1
31	cholesterol metabolic process	GO:008203	9.5	LDLR, LCAT, CETP, LIPC, APOE, IL4
32	cell surface receptor signaling pathway	GO:007166	9.5	F2, EDN2, NPPB, ADRB2, OXTR, IFNG
33	cellular response to lipopolysaccharide	GO:071222	9.4	TNFAIP3, TNFRSF1B, CYP11A1, ABCA1, IL10, CYP17A1
34	response to oxidative stress	GO:006979	9.3	MMP9, MBL2, DHCR24, PTGS1, MPO, CHRNA4
35	response to lipopolysaccharide	GO:032496	9.2	SFTPB, MMP9, IL1A, FAS, TNFRSF1A, APOB
36	negative regulation of interleukin-6 production	GO:032715	9.0	TNFAIP3, TNFRSF1A, TNF, IL10, TLR4
37	positive regulation of membrane protein ectodomain proteolysis	GO:051044	8.9	TNFRSF1B, IL1B, TNF, IFNG, APOE
38	platelet activation	GO:030168	8.8	VEGFA, GP6, ITGB3, IL6, TGFB1, IGF1
39	positive regulation of cell proliferation	GO:008284	8.8	TFAP2B, F2, ADRB2, TGFBR2, TGFBR1, TGFB1
40	positive regulation of mitosis	GO:045840	8.7	TNF, IL1A, EDN1, IGF1, IGF2, IL1B
41	positive regulation of protein phosphorylation	GO:001934	8.7	TNF, IGF2, TGFB1, EP300, TBX1, IL1B
42	small molecule metabolic process	GO:044281	8.6	APOC3, APOC2, APOB, APOA5, APOA4, APOA1
43	positive regulation of nitric oxide biosynthetic process	GO:045429	8.6	TLR4, PTGS2, EDN1, TNF, IL1B, IFNG
44	response to glucocorticoid stimulus	GO:051384	8.5	EP300, IL1B, TNF, PTGS2, PLA2G4A, SFTPB
45	anti-apoptosis	GO:006916	8.2	NR3C1, TNFAIP3, IGF1, FAS, IL1B, IL1A
46	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	8.1	IL10, IL1B, IL6, PTEN, ESR1, TRAF2
47	inflammatory response	GO:006954	8.0	IL8, IL10, IL1A, NPPB, TGFB1, IL1B
48	response to hypoxia	GO:001666	7.7	FAS, IL1B, MMP9, IL1A, CHRNA4, KCNA5
49	blood coagulation	GO:007596	INF	ITGB3, ITGA2, VEGFA, F13A1, F5, MMP1
50	response to drug	GO:042493	INF	IL1RN, IL10, MMP9, LPL, IL4, APOC2

Molecular functions related to patent ductus arteriosus according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	PTEN, PTGIS, PTGER4, PTPN11, TBX5, TNFRSF1B
2	prostaglandin E receptor activity	GO:004957	10.6	PTGER4, PTGER1, PTGER2, HPGD
3	monooxygenase activity	GO:004497	10.4	CYP2C9, CYP2D6, CYP2E1, CYP2C19, CYP1A2, PTGIS
4	cholesterol transporter activity	GO:017127	10.3	ABCA1, APOB, APOA4, APOA1, CETP
5	electron carrier activity	GO:009055	10.2	CYP2D6, CYP11A1, CYP11B1, CYP17A1, CYP2C9, CYP2E1
6	cholesterol binding	GO:015485	10.1	ABCA1, CYP11A1, APOC3, APOA1, CETP
7	lipid binding	GO:008289	9.8	PTGS1, PTGS2, PTEN, APOE, APOC2, APOA5
8	iron ion binding	GO:005506	9.8	CYP11A1, CYP11B1, CYP17A1, CYP2C9, NOS2, CYP2D6
9	steroid binding	GO:005496	9.5	PGR, NR3C1, ESR1, HSD11B2, SERPINA6
10	heme binding	GO:020037	9.2	MPO, NOS2, CYP2C9, CYP17A1, CYP11B1, CYP11A1
11	enzyme binding	GO:019899	9.1	PGR, DHCR24, TGFB1, CYP2E1, CYP2C19, CYP1A2
12	protein homodimerization activity	GO:042803	8.7	TFAP2B, TGFB1, SHMT1, NOS2, NR3C1, TBX1
13	growth factor activity	GO:008083	7.6	IGF2, IGF1, F2, TGFB1, IL6, IL5
14	cytokine activity	GO:005125	7.5	EDN1, TNF, IFNG, IL6, IL5, IL4