PAD
MCID: PTN002
MIFTS: 57

Patent Ductus Arteriosus (PAD) malady

Genetic diseases, Rare diseases, Cardiovascular diseases, Fetal diseases categories

Summaries for Patent Ductus Arteriosus

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Sources:
66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Patent ductus arteriosus (PDA) is a congenital disorder in the heart wherein a neonate\'s ductus... more...

MalaCards: Patent Ductus Arteriosus, also known as patent ductus arteriosus, susceptibility to, is related to hypertension and ventricular septal defect, and has symptoms including antenatal exposure : rubella, autosomal recessive inheritance and tetralogy of fallot/trilogy of fallot. An important gene associated with Patent Ductus Arteriosus is PDA1 (Patent ductus arteriosus, susceptibility to). The compounds arachidonic acid and mspi have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related mouse phenotype homeostasis/metabolism.

Description from OMIM:48 607411

Aliases & Classifications for Patent Ductus Arteriosus

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Sources:
9Disease Ontology, 10diseasecard, 44NIH Rare Diseases, 48OMIM, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 41NCIt, 59SNOMED-CT, 28ICD9CM, 36MeSH, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

50
patent ductus arteriosus:
Inheritance: Autosomal dominant,Autosomal recessive,Multigenic/multifactorial; Prevalence: 1-5/10000; Age of onset: Neonatal/infancy; Age of death: Normal


Aliases & Descriptions:

patent ductus arteriosus 9 44 48 11 50
patent ductus arteriosus, susceptibility to 10
patent ductus arteriosus - persisting type 9
persistent patency of the arterial duct 50
patent ductus arteriosus familial 44
patency of the ductus arteriosus 44
ductus arteriosus patent 46
patent ductus botalli 9
patent arterial duct 50
pad mass 63
pda1 44
pad 50
pda 44


External Ids:

Disease Ontology9 DOID:13832
NCIt41 C84492
ICD9CM28 747.0
OMIM48 607411
MeSH36 D004374
ICD10 via Orphanet27 Q25.0
SNOMED-CT via Orphanet60 83330001
UMLS via Orphanet64 C0013274
ICD1026 Q25.0

Related Diseases for Patent Ductus Arteriosus

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Patent Ductus Arteriosus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 203)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension10.9
2ventricular septal defect10.9
3aneurysm10.9
4right aortic arch10.8
5char syndrome10.8
6aortic coarctation10.8
7endocarditis10.7
8cerebritis10.7
9subacute bacterial endocarditis10.6
10thrombocytopenia10.6
11pulmonic stenosis10.6
12thoracic aortic aneurysm10.6
13aortic aneurysm10.6
14bronchopulmonary dysplasia10.6
15eisenmenger syndrome10.6
16tetralogy of fallot10.5
17esophagitis10.5
18intestinal perforation10.5
19pulmonary atresia with intact ventricular septum10.5
20coronary arterial fistulas10.5
21patent ductus arteriosus - bicuspid aortic valve - hand anomalies10.5
22scimitar syndrome10.4
23biliary atresia10.4
24brachydactyly10.4
25congenital heart disease10.4
26intestinal pseudo-obstruction10.4
27holt-oram syndrome10.4
28aortic arch interruption10.4
29cantu syndrome10.4
30congenital mitral stenosis10.4
31congenital rubella10.4
32cor triatriatum10.4
33coronary artery aneurysm10.4
34gorlin chaudhry moss syndrome10.4
35natal teeth, intestinal pseudoobstruction and patent ductus10.4
36thanatophoric dysplasia type 110.4
37zimmermann-laband syndrome10.4
38pulmonary artery hypoplasia10.4
39congenital patent ductus arteriosus aneurysm10.4
40pulmonary artery coming from patent ductus arteriosus10.4
41hand-foot-genital syndrome10.4
42transposition of the great arteries10.4
43rubella10.3
44williams-beuren syndrome10.3
45hajdu-cheney syndrome10.3
46klippel-trenaunay syndrome10.3
47mitral valve prolapse10.3
48charge syndrome10.3
49orotic aciduria10.3
50focal dermal hypoplasia10.3

Graphical network of the top 20 diseases related to Patent Ductus Arteriosus:



Diseases related to patent ductus arteriosus

Symptoms for Patent Ductus Arteriosus

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Sources:
48OMIM, 50Orphanet
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Clinical features from OMIM:

607411

Symptoms:

50 (show all 20)
  • antenatal exposure : rubella
  • autosomal recessive inheritance
  • tetralogy of fallot/trilogy of fallot
  • terminal broadening/clubbing of toes
  • prematurity
  • failure to thrive/difficulties for feeding in infancy/growth delay
  • heart/cardiac failure
  • cardiac rhythm disorder/arrhythmia
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • patent ductus arteriosus
  • autosomal dominant inheritance
  • asthenia/fatigue/weakness
  • high forehead
  • flat face
  • broad nose/nasal bridge
  • respiratory rhythm disorder
  • apnea/sleep apnea
  • pulmonary hypertension
  • repeat respiratory infections
  • short/small nose

Drugs & Therapeutics for Patent Ductus Arteriosus

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Patent Ductus Arteriosus

Drug clinical trials:

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Search NIH Clinical Center for Patent Ductus Arteriosus

Search CenterWatch for Patent Ductus Arteriosus

Genetic Tests for Patent Ductus Arteriosus

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Anatomical Context for Patent Ductus Arteriosus

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Sources:
34MalaCards
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MalaCards organs/tissues related to Patent Ductus Arteriosus:

34
Heart, Lung, Brain, Testes, Eye, Smooth muscle, Liver

Animal Models for Patent Ductus Arteriosus or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Patent Ductus Arteriosus:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.2FOLR1, FABP3, APOA4, PTGES2, KCNA5, TFAP2B

Publications for Patent Ductus Arteriosus

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Sources:
53PubMed
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Articles related to Patent Ductus Arteriosus:

(show top 50)    (show all 574)
idTitleAuthorsYear
1
Outcomes of Primary Ligation of Patent Ductus Arteriosus Compared With Secondary Ligation After Pharmacologic Failure in Very-Low-Birth-Weight Infants. (24370764)
2013
2
Unexpected co-arctation of aorta detected by transesophageal echocardiography during patent ductus arteriosus ligation. (23681889)
2013
3
Transcatheter closure of large patent ductus arteriosus using custom made devices. (24323820)
2013
4
A different first-choice drug in the medical management of patent ductus arteriosus: oral paracetamol. (23205872)
2013
5
Patent ductus arteriosus detected on 64-multidetector row CT. (23370756)
2013
6
Challenges in device closure of a large patent ductus arteriosus in infants weighing less than 6 kg. (23017089)
2013
7
Serum ibuprofen levels of extremely preterm infants treated prophylactically with oral ibuprofen to prevent patent ductus arteriosus. (23128963)
2013
8
Long-Term Outcome in Dogs with Patent Ductus Arteriosus: 520 Cases (1994-2009). (24372855)
2013
9
Closure of patent ductus arteriosus in children, small infants, and premature babies with Amplatzer duct occluder II additional sizes: multicenter study. (23460349)
2013
10
Interparametric correlation between echocardiographic markers in preterm infants with patent ductus arteriosus. (23370640)
2013
11
Giant aneurysm of the Valsalva sinus associated with multiple coronary artery aneurysms and patent ductus arteriosus. (24092249)
2013
12
Patent ductus arteriosus in an adult amur leopard (Panthera pardus orientalis). (23505729)
2013
13
Patent ductus arteriosus closure using an Amplatzer(a8c) ventricular septal defect closure device. (24294051)
2013
14
Patent ductus arteriosus, low platelets, cyclooxygenase inhibitors, and intraventricular hemorrhage in very low birth weight preterm infants. (23351600)
2013
15
Morphology of the patent ductus arteriosus does not preclude successful patent ductus arteriosus stent implantation in high-risk patients undergoing hybrid stage I palliation: recommendations to optimize ductal stent positioning. (23704074)
2013
16
Stent angioplasty to relieve left pulmonary artery obstruction caused by patent ductus arteriosus device occlusion: bipartisan teamwork by two interventional devices. (23359589)
2013
17
Percutaneous closure of a moderate to large tubular or elongated patent ductus arteriosus in children younger than 3 years: is the ADO II appropriate? (23591801)
2013
18
When to treat hemodynamically insignificant patent ductus arteriosus in preterm infants. (24027704)
2012
19
Oral ibuprofen versus intravenous ibuprofen or intravenous indomethacin for the treatment of patent ductus arteriosus in preterm infants: a systematic review and meta-analysis. (22414850)
2012
20
Analyzing the failures of percutaneous closure of the patent ductus arteriosus in patients over 5 kg. (22954562)
2012
21
Use of targeted neonatal echocardiography to prevent postoperative cardiorespiratory instability after patent ductus arteriosus ligation. (22050874)
2012
22
Vocal cord paralysis post patent ductus arteriosus ligation surgery: risks and co-morbidities. (22959601)
2012
23
Thrombocytopenia in the first 24 hours after birth and incidence of patent ductus arteriosus. (22869835)
2012
24
Antenatal calcium channel blocker exposure and subsequent patent ductus arteriosus in extremely low-birth-weight infants. (21861146)
2012
25
Different transcatheter strategies for aortic coarctation associated with patent ductus arteriosus. (22929832)
2012
26
Transcatheter closure of patent ductus arteriosus using ado device: retrospective study of 149 patients. (22754633)
2012
27
Percutaneous closure of a post-traumatic ventricular septal defect with a patent ductus arteriosus occluder. (23184204)
2012
28
Plasma C-terminal pro-endothelin-1 and the natriuretic pro-peptides NT-proBNP and MR-proANP in very preterm infants with patent ductus arteriosus. (21952518)
2012
29
Treatment of patent ductus arteriosus with bidirectional flow in neonates. (21402454)
2011
30
Video-assisted thoracoscopic patent ductus arteriosus closure without tube thoracostomy. (21524494)
2011
31
Does thrombocytopenia contribute to patent ductus arteriosus? (21217670)
2011
32
Aneurysm of a patent ductus arteriosus. (21299627)
2011
33
Transcatheter occlusion of patent ductus arteriosus in pre-term infants. (20488412)
2010
34
Safe retrieval of embolized patent ductus arteriosus coil via left thoracotomy. (20959885)
2010
35
Dynamic volume 320-slice CT in the assessment of patent ductus arteriosus for percutaneous closure. (20194213)
2010
36
Interrupted aortic arch diagnosed with loss of femoral pulse in a patient undergoing patent ductus arteriosus ligation -A case report-. (20532057)
2010
37
Patent ductus arteriosus of the preterm infant. (20421261)
2010
38
Subcutaneous fat necrosis of the newborn associated with ventricular septal defect and patent ductus arteriosus. (19702998)
2009
39
Transcatheter closure of patent ductus arteriosus using the amplatzer duct occluder in infants under one year of age. (23040378)
2009
40
Unilateral vocal fold paralysis in premature infants after ligation of patent ductus arteriosus: vascular clip versus suture ligature. (19894404)
2009
41
Response to the case report of pulmonary artery coil migration after management of patent ductus arteriosus in a 65-year-old female patient. (19666447)
2009
42
Role of prophylactic surgical ligation of patent ductus arteriosus in extremely low birth weight infants: Systematic review and implications for clinical practice. (20808624)
2009
43
Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus. (16444274)
2006
44
Maternal and offspring MTHFR gene C677T polymorphism as predictors of congenital atrial septal defect and patent ductus arteriosus. (16373366)
2006
45
Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus. (15353504)
2004
46
Patent ductus arteriosus in fetal valproate syndrome. (14510093)
2003
47
Repair of aortopulmonary window at left thoracotomy for patent ductus arteriosus. (6825496)
1983
48
The effect of tolazoline on right-to-left shunting via a patent ductus arteriosus in meconium aspiration syndrome. (803084)
1976
49
Aortic arch interruption associated with patent ductus arteriosus, ventricular septal defect, and total anomalous pulmonary venous connection. Total correction in an 8-day-old infant by means of profound hypothermia and limited cardiopulmonary bypass. (5011273)
1972
50
Scimitar syndrome associated with patent ductus arteriosus, aortic coarctation and irreversible pulmonary hypertension. (4236474)
1968

Variations for Patent Ductus Arteriosus

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Expression for genes affiliated with Patent Ductus Arteriosus

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Patent Ductus Arteriosus

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Pathways for genes affiliated with Patent Ductus Arteriosus

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Compounds for genes affiliated with Patent Ductus Arteriosus

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Sources:
46Novoseek, 30IUPHAR, 25HMDB, 12DrugBank
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Compounds related to Patent Ductus Arteriosus according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1arachidonic acid46 30 25 1212.1FABP3, PTGES2, EDN2
2mspi469.1FOLR1, APOA4
3glucose468.3FABP3, APOA4, TFAP2B, DEFB1

GO Terms for genes affiliated with Patent Ductus Arteriosus

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17Gene Ontology
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Biological processes related to Patent Ductus Arteriosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1potassium ion homeostasisGO:0550759.9TFAP2B, KCNA5
2regulation of insulin secretionGO:0507969.8KCNA5, TFAP2B
3prostaglandin biosynthetic processGO:0015169.7PTGES2, EDN2
4regulation of vasoconstrictionGO:0192299.7EDN2, KCNA5
5cholesterol homeostasisGO:0426329.1FABP3, APOA4

Products for genes affiliated with Patent Ductus Arteriosus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Patent Ductus Arteriosus

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet