MCID: PTN001
MIFTS: 62

Patent Foramen Ovale malady

Rare diseases, Cardiovascular diseases, Fetal diseases, Endocrine diseases categories
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Summaries for Patent Foramen Ovale

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Wikipedia:65 Atrial septal defect (ASD) is a form of a congenital heart defect that lets blood flow between the... more...

MalaCards based summary: Patent Foramen Ovale, also known as ostium secundum type atrial septal defect, is related to pulmonary embolism and retinal artery occlusion. An important gene associated with Patent Foramen Ovale is NKX2-5 (NK2 homeobox 5), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and HOP Signaling. The compounds mucicarmine and coumarins have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and thyroid, and related mouse phenotypes are muscle and respiratory system.

Aliases & Classifications for Patent Foramen Ovale

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
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Patent Foramen Ovale, Aliases & Descriptions:

Name: Patent Foramen Ovale 8 10 48
Ostium Secundum Type Atrial Septal Defect 8 62
Atrial Septal Defect Within Oval Fossa 8 62
Foramen Ovale Patent 8 44
Thyroid Hormone Plasma Membrane Transport Defect 62
Atrial Septal Defect, Ostium Secundum Type 48
Atrial Septal Defect Ostium Secundum 42
Persistent, Ostium Secundum 8
 
Persistent Ostium Secundum 8
Asd, Ostium Secundum Type 48
Autism Spectrum Disorders 62
Asd Ostium Secundum Type 42
Foramen Ovale, Patent 62
Ostium Secundum Asd 42
Defect, Patent 8


Classifications:



External Ids:

Disease Ontology8 DOID:13620
NCIt39 C34619
MeSH34 D054092
MESH via Orphanet35 D054092
ICD10 via Orphanet26 Q21.1
UMLS via Orphanet63 C0016522, C0344724

Related Diseases for Patent Foramen Ovale

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Diseases related to Patent Foramen Ovale via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 137)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary embolism31.8FGA, F5, APOH
2retinal artery occlusion31.7APOH
3thromboembolism31.5F12, APOH, F5, FGA
4myocardial infarction31.2FGA, GATA4, F5
5antiphospholipid syndrome31.1F5, APOH
6thrombophilia31.1F12, APOH, F5, FGA
7ventricular septal defect31.0NKX2-5
8venous thrombosis30.9FGA, F5, APOH, F12
9cerebrovascular disease30.9APOH, F12
10hyperhomocysteinemia30.8F5, APOH
11congenital heart disease30.5GATA4, NKX2-5
12noonan syndrome30.5MYH6, ACTC1, NKX2-5, GATA4
13aneurysm11.2
14migraine11.1
15atrial septal aneurysm11.1
16cerebritis10.9
17headache10.9
18migraine with aura10.8
19hypertension10.7
20pulmonary hypertension10.7
21obstructive sleep apnea10.7
22sleep apnea10.7
23retinitis10.7
24endocarditis10.6
25ischemia10.6
26tetrology of fallot10.6NKX2-5
27pulmonic stenosis10.6
28transposition of the great arteries10.6
29sneddon syndrome10.5APOH
30thrombophlebitis10.5APOH
31acute myocardial infarction10.5
32aortic atherosclerosis10.5
33arteriovenous fistula10.5
34atherosclerosis10.5
35chronic obstructive pulmonary disease10.5
36central retinal artery occlusion10.5
37acute cor pulmonale10.5
38arteriovenous malformation10.5
39cor triatriatum10.5
40hemiplegic migraine10.5
41pulmonary arteriovenous malformation10.5
42hypoxia10.5
43spinal cord infarction10.5
44cor pulmonale10.5
45persistent eustachian valve10.5
46sternal cleft10.4
47antithrombin iii deficiency10.4APOH, F5
48mondor disease10.4APOH, F5
49factor xi deficiency10.4F12, F5
50prothrombin deficiency10.4APOH, F5

Graphical network of the top 20 diseases related to Patent Foramen Ovale:



Diseases related to patent foramen ovale

Symptoms for Patent Foramen Ovale

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Drugs & Therapeutics for Patent Foramen Ovale

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Drug clinical trials:

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Genetic Tests for Patent Foramen Ovale

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Anatomical Context for Patent Foramen Ovale

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MalaCards organs/tissues related to Patent Foramen Ovale:

32
Brain, Heart, Thyroid, Spinal cord, Liver, Lung, Testes, Endothelial

Animal Models for Patent Foramen Ovale or affiliated genes

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Publications for Patent Foramen Ovale

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Articles related to Patent Foramen Ovale:

(show top 50)    (show all 593)
idTitleAuthorsYear
1
Patent foramen ovale and gut ischemia in potential intestinal transplant recipients. (25221903)
2014
2
Decline in mean platelet volume in patients with patent foramen ovale undergoing percutaneous closure. (25192299)
2014
3
Is closure of patent foramen ovale to prevent ischaemic stroke ever justified? (24167203)
2013
4
Neonatal systemic thromboembolism secondary to ductus arteriosus aneurysm and patent foramen ovale. (21801317)
2013
5
Determination of the Optimum Number of Cardiac Cycles to Differentiate Intra-Pulmonary Shunt and Patent Foramen Ovale by Saline Contrast Two- and Three-Dimensional Echocardiography. (24028319)
2013
6
Current evidence for closure of a patent foramen ovale for cryptogenic stroke prevention. (24373020)
2013
7
Thrombus formation in a patent foramen ovale. (23528287)
2013
8
Death by patent foramen ovale in a soccer player. (23468450)
2013
9
Patent foramen ovale in severe obstructive sleep apnea: clinical features and effects of closure. (22924163)
2013
10
Neuroimaging findings in cryptogenic stroke patients with and without patent foramen ovale. (23339957)
2013
11
Patent Foramen Ovale and Migraine Attacks: A Systematic Review. (24355354)
2013
12
Management of the stroke patient with patent foramen ovale: new insights and persistent questions in the wake of recent randomized trials. (23715857)
2013
13
Neurosurgery in the Semisitting Position in Patients with a Patent Foramen Ovale. (23920299)
2013
14
A systematic review of closure versus medical therapy for preventing recurrent stroke in patients with patent foramen ovale and cryptogenic stroke or transient ischemic attack. (24300230)
2013
15
Follow-up to 'Cholecystectomy in the presence of a large patent foramen ovale: laparoscopic or open?'. (23541851)
2013
16
Patent foramen ovale and atrial septal aneurysm can cause ischemic stroke in patients with antiphospholipid syndrome. (22836909)
2013
17
Updating the evidence on patent foramen ovale closure versus medical therapy in patients with cryptogenic stroke: aa8^systematic review and comprehensive meta-analysis of 2,303 patients from three randomised trials and 2,231 patients from 11 observational studies. (24240356)
2013
18
Effectiveness of percutaneous closure of patent foramen ovale for hypoxemia. (23871675)
2013
19
Platypnoea-orthodeoxia in an elderly man with patent foramen ovale and dilated ascending aorta. (22089080)
2012
20
Platypnea-orthodeoxia syndrome related to right hemidiaphragmatic elevation and a 'stretched' patent foramen ovale. (23230257)
2012
21
Patent foramen ovale, dialysis and microembolization. (22487266)
2012
22
Secondary stroke prevention: patent foramen ovale, aortic plaque, and carotid stenosis. (22422912)
2012
23
Simultaneous myocardial infarction and ischaemic stroke secondary to paradoxical emboli through a patent foramen ovale. (22930890)
2012
24
Stress-induced cardiomyopathy after patent foramen ovale closure: what role did anesthesia play? (22633744)
2012
25
Prevalence of patent foramen ovale with right-to-left shunting in dogs with pulmonic stenosis. (22151278)
2012
26
Focal neurological deficit with tricuspid endocarditis and patent foramen ovale. (22878350)
2012
27
Transcranial Doppler quantification of residual shunt after percutaneous patent foramen ovale closure: correlation of device efficacy with intracardiac anatomic measures. (22364421)
2012
28
Can patent foramen ovale affect rehabilitation? The uncommon association of platypnea-orthodeoxia syndrome and stroke. (21468677)
2011
29
Electrocardiographic changes and arrhythmias following percutaneous atrial septal defect and patent foramen ovale device closure. (21563292)
2011
30
Transthoracic echocardiography guidance during percutaneous closure of patent foramen ovale. (21967656)
2011
31
Contrast transoesophageal echocardiography remains superior to contrast-enhanced cardiac magnetic resonance imaging for the diagnosis of patent foramen ovale. (21193485)
2011
32
Role of patent foramen ovale in migraine etiology and treatment: a review. (21827543)
2011
33
Explantation of patent foramen ovale closure devices: a multicenter survey. (21596333)
2011
34
Risk and fate of residual interatrial shunting after transcatheter closure of patent foramen ovale: a long term follow up study. (21345765)
2011
35
Interatrial septal aneurysm and patent foramen ovale: diagnosis and dynamic evaluation with electrocardiogram-gated multidetector-row computed tomography imaging. (21079517)
2011
36
Usefulness of intravenously administered fluid replenishment for detection of patent foramen ovale by transesophageal echocardiography. (20854974)
2010
37
Late cardiac perforation after transcatheter closure of patent foramen ovale mimicking acute type a aortic dissection. (20417804)
2010
38
The association of patent foramen ovale transcatheter closure and psychological well-being. (20089005)
2010
39
Patent foramen ovale among patients with mild chronic obstructive pulmonary disease and unexplained hypoxia. (20345439)
2010
40
Acute myocardial infarction involving two coronary arteries due to a patent foramen ovale. (20676784)
2010
41
Patent foramen ovale and obstructive sleep apnea: a new association? (20451427)
2010
42
A case of platypnea-orthodeoxia syndrome caused by the interaction between the presence of corrected transposition of the great arteries and patent foramen ovale. (18706706)
2010
43
Paradoxical emboli--clinical importance of transcranial Doppler for detection of patent foramen ovale. (21443152)
2010
44
A third treatment option for entrapped thrombus in patent foramen ovale. (20548835)
2010
45
Lack of association between migraine headache and patent foramen ovale: results of a case-control study. (20231534)
2010
46
A gain-of-function TBX20 mutation causes congenital atrial septal defects, patent foramen ovale and cardiac valve defects. (19762328)
2010
47
No indication for patent foramen ovale closure in migraine. (19949472)
2009
48
Do common prothrombotic mutations influence the risk of cerebral ischaemia in patients with patent foramen ovale? Systematic review and meta-analysis. (19404532)
2009
49
That balloon atrial septostomy is associated with preoperative stroke in neonates with transposition of the great arteries is another powerful argument in favor of therapeutic closure of every patent foramen ovale. (16828611)
2006
50
Atrial septal aneurysm plus a patent foramen ovale. A predisposing factor for paradoxical embolism and refractory hypoxemia during pulmonary embolism. (8797439)
1996

Variations for Patent Foramen Ovale

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Expression for genes affiliated with Patent Foramen Ovale

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Expression patterns in normal tissues for genes affiliated with Patent Foramen Ovale

Search GEO for disease gene expression data for Patent Foramen Ovale.

Pathways for genes affiliated with Patent Foramen Ovale

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Pathways related to Patent Foramen Ovale according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0GATA4, NKX2-5
210.0GATA4, NKX2-5
310.0GATA4, GATA6
4
Show member pathways
9.7GATA4, GATA6, NKX2-5
5
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility60
Cytoskeleton remodeling Integrin outside in signaling60
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases60
Cell adhesion Tight junctions60
Development MAG dependent inhibition of neurite outgrowth60
9.4MYH6, ACTC1, NKX2-1
69.3NKX2-5, TBX20, GATA6, GATA4
79.0GATA4, TBX20, NKX2-5, ACTC1, MYH6
8
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
8.8FGA, F5, F12
9
Show member pathways
8.8F12, F5, FGA
10
Show member pathways
8.4TLL1, F12, F5, FGA
11
Show member pathways
8.3FGA, GATA4, GATA6, F5, F12

Compounds for genes affiliated with Patent Foramen Ovale

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Compounds related to Patent Foramen Ovale according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1mucicarmine4410.0NKX2-1, ACTC1
2coumarins449.8APOH, F5
3b 723449.8ACTC1, NKX2-1
4methanol44 2410.7ACTC1, APOH
5hirugen449.6F5, FGA
6batroxobin449.6FGA, F5
7nafamostat mesilate449.6FGA, F5
8cardiolipin44 1110.6F5, APOH
9ancrod449.6FGA, F5
10bivalirudin44 1110.6FGA, F5
11argatroban44 1110.5F5, FGA
12kaolin449.5F5, APOH, F12
13kininogen449.5F5, APOH, F12
14cacl2449.5FGA, F5
1511-dehydrothromboxane b2449.5APOH, FGA
166-ketoprostaglandin f1alpha449.4FGA, APOH
17polyacrylamide449.4APOH, MYH6, F5
18ticlopidine44 1110.4APOH, FGA
19ptca449.4FGA, APOH
20progesterone44 28 61 24 1113.4GATA4, F5, ACTC1, APOH
21coumarin44 2 50 2412.3FGA, F5
22hirudin449.2FGA, F5
23phosphatidylethanolamine44 1110.2F5, APOH
24warfarin44 50 24 1112.1APOH, F5, FGA
25malondialdehyde449.1APOH, F5, FGA
26pge1449.0APOH, F5, FGA
27endotoxin449.0APOH, F5, FGA
28prostacyclin448.9FGA, F5, APOH
29nitric oxide44 24 1110.9APOH, NKX2-5, F5, GATA4
30retinoic acid44 249.8MYH6, ACTC1, NKX2-1, F5, GATA6, GATA4
31creatinine448.7FGA, F5, ACTC1, APOH
32zinc44 249.7F12, APOH, NKX2-5, NKX2-1, GATA6, GATA4
33aspirin44 50 28 2411.7F12, APOH, F5, FGA
34fibrinogen448.6F12, APOH, F5, FGA
35cholesterol44 28 24 1111.6FGA, GATA6, F5, APOH
36steroid448.6APOH, ACTC1, NKX2-1, F5, GATA6, GATA4
37heparin44 28 24 1111.6F12, APOH, F5, FGA
38estrogen448.2F12, APOH, MYH6, ACTC1, NKX2-1, F5
39calcium44 50 24 1111.0FGA, GATA4, F5, ACTC1, MYH6, APOH
40serine447.9F12, MYH6, NKX2-5, NKX2-1, F5, GATA4

GO Terms for genes affiliated with Patent Foramen Ovale

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Cellular components related to Patent Foramen Ovale according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sarcomereGO:0300179.9ACTC1, MYH6
2transcription factor complexGO:0056679.3NKX2-5, NKX2-1, GATA6
3extracellular spaceGO:0056158.0FGA, F5, ACTC1, APOH, F12
4nucleusGO:0056347.3CITED2, POLL, MYH6, NKX2-5, NKX2-1, TBX20

Biological processes related to Patent Foramen Ovale according to GeneCards/GeneDecks:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1intestinal epithelial cell differentiationGO:06057510.3GATA6, GATA4
2embryonic heart tube left/right pattern formationGO:06097110.3NKX2-5, CITED2
3cardiac muscle hypertrophy in response to stressGO:01489810.3GATA4, GATA6
4endocardial cushion developmentGO:00319710.2GATA4, CITED2
5adult heart developmentGO:00751210.2NKX2-5, MYH6
6cardiac muscle cell differentiationGO:05500710.2GATA6, NKX2-5
7cardiac right ventricle morphogenesisGO:00321510.2TBX20, GATA4
8endoderm formationGO:00170610.2TBX20, GATA4
9positive regulation of cardioblast differentiationGO:05189110.1GATA4, GATA6, NKX2-5
10ventricular septum morphogenesisGO:06041210.1NKX2-5, CITED2
11sarcomere organizationGO:04521410.1MYH6, NKX2-5
12Clara cell differentiationGO:06048610.1GATA6, NKX2-1
13BMP signaling pathwayGO:03050910.1GATA4, NKX2-5, MYH6
14lung saccule developmentGO:06043010.0NKX2-1, GATA6
15Type II pneumocyte differentiationGO:06051010.0GATA6, NKX2-1
16canonical Wnt signaling pathwayGO:06007010.0MYH6, NKX2-5, GATA4
17atrial septum morphogenesisGO:06041310.0NKX2-5, TBX20, GATA4
18response to estrogenGO:04362710.0CITED2, GATA6, GATA4
19outflow tract septum morphogenesisGO:00314810.0NKX2-5, TBX20, GATA6
20cardiac muscle tissue morphogenesisGO:05500810.0ACTC1, NKX2-5, TBX20
21positive regulation of cardiac muscle cell proliferationGO:06004510.0GATA4, GATA6, TBX20
22male gonad developmentGO:00858410.0GATA4, GATA6, CITED2
23spleen developmentGO:0485369.9CITED2, NKX2-5
24thyroid gland developmentGO:0308789.9NKX2-5, NKX2-1
25positive regulation of blood coagulationGO:0301949.9APOH, F12
26endoderm developmentGO:0074929.8NKX2-1, GATA4
27muscle filament slidingGO:0300499.8ACTC1, MYH6
28blood coagulation, intrinsic pathwayGO:0075979.8APOH, F12
29in utero embryonic developmentGO:0017019.7GATA4, GATA6, MYH6
30heart loopingGO:0019479.7CITED2, NKX2-5, TBX20, GATA4
31cardiac muscle contractionGO:0600489.7NKX2-5, ACTC1
32blood circulationGO:0080159.6F5, TBX20
33negative regulation of apoptotic processGO:0430669.6GATA6, NKX2-5, ACTC1, CITED2
34negative regulation of transcription, DNA-templatedGO:0458929.6CITED2, NKX2-5, TBX20, GATA6
35positive regulation of transcription, DNA-templatedGO:0458939.4CITED2, NKX2-5, NKX2-1, GATA4
36negative regulation of transcription from RNA polymerase II promoterGO:0001229.1CITED2, NKX2-5, NKX2-1, TBX20, GATA6
37positive regulation of transcription from RNA polymerase II promoterGO:0459448.9CITED2, NKX2-5, NKX2-1, TBX20, GATA6, GATA4
38blood coagulationGO:0075968.7F12, F5, GATA6, GATA4, FGA

Molecular functions related to Patent Foramen Ovale according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription coactivator activityGO:0011059.8TBX20, CITED2
2RNA polymerase II regulatory region sequence-specific DNA bindingGO:0009779.7TBX20, GATA4
3transcription factor bindingGO:0081349.7GATA4, GATA6, NKX2-5
4chromatin bindingGO:0036829.5CITED2, NKX2-5, GATA6, GATA4
5RNA polymerase II activating transcription factor bindingGO:0011029.5TBX20, CITED2
6RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:0037059.4GATA4, GATA6, NKX2-1, NKX2-5
7transcription regulatory region DNA bindingGO:0442129.4NKX2-5, NKX2-1, GATA6, GATA4
8sequence-specific DNA binding transcription factor activityGO:0037008.6CITED2, NKX2-5, NKX2-1, TBX20, GATA6, GATA4
9protein bindingGO:0055156.7F12, APOH, CITED2, NKX2-5, NKX2-1, F5

Products for genes affiliated with Patent Foramen Ovale

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Sources for Patent Foramen Ovale

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet