MCID: PTN001
MIFTS: 56

Patent Foramen Ovale malady

Cardiovascular, Fetal, Endocrine categories

Summaries for Patent Foramen Ovale

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Atrial septal defect (ASD) is a form of congenital heart defect that enables blood flow between two... more...

MalaCards: Patent Foramen Ovale, also known as atrial septal defect within oval fossa, is related to stroke, ischemic and thromboembolism. An important gene associated with Patent Foramen Ovale is NKX2-5 (NK2 homeobox 5), and among its related pathways are Platelet activation, signaling and aggregation and Platelet degranulation . The compounds coumarins and warfarin have been mentioned in the context of this disorder. Affiliated tissues include liver, spinal cord and brain, and related mouse phenotypes are reproductive system and cardiovascular system.

Aliases & Classifications for Patent Foramen Ovale

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal
Anatomical: Cardiovascular, Endocrine


Aliases & Descriptions:

patent foramen ovale 8 10 49
atrial septal defect within oval fossa 8 61
foramen ovale patent 8 45
thyroid hormone plasma membrane transport defect 61
ostium secundum type atrial septal defect 8
atrial septal defect ostium secundum 43
persistent, ostium secundum 8
persistent ostium secundum 8
asd ostium secundum type 43
foramen ovale, patent 61
ostium secundum asd 43
defect, patent 8


External Ids:

Disease Ontology8 DOID:13620
NCIt40 C34619
MeSH35 D054092
MESH via Orphanet36 D054092
ICD10 via Orphanet26 Q21.1
SNOMED-CT via Orphanet58 204317008
UMLS via Orphanet62 C0016522

Related Diseases for Patent Foramen Ovale

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Patent Foramen Ovale via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 237)
idRelated DiseaseScoreTop Affiliating Genes
1stroke, ischemic31.4F5, F2
2thromboembolism30.9APOH, F5, MTHFR, F12, FGA, F2
3thrombophilia30.7F13A1, F12, FGA, F2, PLAT, SERPINC1
4central retinal artery occlusion30.6PLAT
5acute myocardial infarction30.6FGA, PLAT, SERPINC1
6antiphospholipid syndrome30.6APOH, F5, MTHFR, F2, PLAT, SERPINC1
7venous thrombosis30.6APOH, F5, MTHFR, F12, FGA, F2
8atherosclerosis30.6EDNRA, MTHFR, F13A1, FGA, PLAT, SERPINC1
9branch retinal artery occlusion30.4F5
10sickle cell disease30.4FGA
11primary pulmonary hypertension30.4FGA
12protein c deficiency30.4APOH, F5, MTHFR, F2, SERPINC1
13hyperhomocysteinemia30.4APOH, F5, MTHFR, F2, PLAT, SERPINC1
14atrial septal aneurysm11.1
15headache10.8
16sleep apnea10.7
17thyroid hormone plasma membrane transport defect10.6
18pulmonic stenosis10.5
19atrial septal defect 810.5
20mitral valve prolapse10.4
21noonan syndrome10.4
22n syndrome10.4
23aortic atherosclerosis10.4
24aortic aneurysm10.4
25char syndrome10.4
26hemiplegic migraine10.4
27hypoxia10.4
28pulmonary disease, chronic obstructive10.4
29glanzmann's thrombasthenia10.4
30takayasu's arteritis10.4
31atrioventricular septal defect10.4
32congenital diaphragmatic hernia10.4
33atrial heart septal defect10.4
34urea cycle disorder10.4
35hereditary folate malabsorption10.4
36zap70-related severe combined immunodeficiency10.4
37acro-pectoro-renal field defect10.4
38ankle defects short stature10.4
39axial mesodermal dysplasia spectrum10.4
40branchial arch defects10.4
41cardioskeletal syndrome kuwaiti type10.4
42sacral defect with anterior meningocele10.4
43caudal regression syndrome10.4
44chylomicron retention disease10.4
45x-linked creatine deficiency10.4
46cystinosis, ocular nonnephropathic10.4
47hmg coa lyase deficiency10.4
48imerslund-grasbeck syndrome10.4
49defective apolipoprotein b-10010.4
50diaphragmatic hernia upper limb defects10.4

Graphical network of the top 20 diseases related to Patent Foramen Ovale:



Diseases related to patent foramen ovale

Clinical Features for Patent Foramen Ovale

Drugs & Therapeutics for Patent Foramen Ovale

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Patent Foramen Ovale

Drug clinical trials:

Search ClinicalTrials for Patent Foramen Ovale

Search NIH Clinical Center for Patent Foramen Ovale

Search CenterWatch for Patent Foramen Ovale

Genetic Tests for Patent Foramen Ovale

Anatomical Context for Patent Foramen Ovale

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Patent Foramen Ovale:

33
Liver, Spinal cord, Brain, Lung, Heart, Thyroid, T cells, B cells, Endothelial

Animal Models for Patent Foramen Ovale or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Patent Foramen Ovale

Sources:
51PubMed
See all sources

Articles related to Patent Foramen Ovale:

(show top 50)    (show all 583)
idTitleAuthorsYear
1
Pacing via a patent foramen ovale: computed tomographic identification of unusual lead positioning. (24413759)
2014
2
Patent Foramen Ovale and Migraine Attacks: A Systematic Review. (24355354)
2013
3
Incidence of patent foramen ovale and migraine headache in adults with congenital heart disease with no known cardiac shunts. (22927216)
2013
4
Diagnostic Accuracy of Transesophageal Echocardiogram for the Detection of Patent Foramen Ovale: A Meta-Analysis. (24372693)
2013
5
Patent foramen ovale and migraine: what is the relationship between the two? (23484805)
2013
6
Safety and performance of the Spidera8c patent foramen ovale occluder. (22887130)
2013
7
No closure for patent foramen ovale in obstructive sleep apnea? (23381335)
2013
8
Initial clinical experience with the GORE septal occluder for the treatment of atrial septal defects and patent foramen ovale. (24058079)
2013
9
Patent foramen ovale and cryptogenic stroke. (23822785)
2013
10
The brain's heart - therapeutic opportunities for patent foramen ovale (PFO) and neurovascular disease. (23528225)
2013
11
Management of patients with patent foramen ovale and cryptogenic stroke: a collaborative, multidisciplinary, position paper: executive summary. (23788390)
2013
12
Catastrophic paradoxical embolus after hemodialysis access thrombectomy in a patient with a patent foramen ovale. (22367171)
2013
13
Clinical Practice, Resource Utilization, and Outcomes of Device Closure of Patent Foramen Ovale in Pediatrics. (24433855)
2013
14
Comparison of two-dimensional versus real-time three-dimensional transesophageal echocardiography for evaluation of patent foramen ovale morphology. (23352264)
2013
15
Effect of percutaneous closure of patent foramen ovale on post-procedural arrhythmias. (24036023)
2013
16
Prevalence and prognostic value of acute cor pulmonale and patent foramen ovale in ventilated patients with early acute respiratory distress syndrome: a multicenter study. (23860806)
2013
17
Patent foramen ovale closure prior to surgery in the sitting position. (24304266)
2013
18
Diagnostic value of transthoracic echocardiography for patent foramen ovale: a meta-analysis. (23820251)
2013
19
Platypnea-orthodeoxia syndrome related to right hemidiaphragmatic elevation and a 'stretched' patent foramen ovale. (23230257)
2012
20
The effect of patent foramen ovale closure on visual aura without headache or typical aura with migraine headache. (22721665)
2012
21
Transoesophageal echocardiography can help distinguish between patients with "symptomatic" and "asymptomatic" patent foramen ovale. (23264244)
2012
22
Transcatheter closure of patent foramen ovale for hypoxemia during left ventricular assist device support. (22607124)
2012
23
Is the patent foramen ovale closure the best option? (23295421)
2012
24
Late left atrial thrombosis of an Amplatzer patent foramen ovale occluder may be the result of Kounis hypersensitivity-associated syndrome. (22710041)
2012
25
Contrast transoesophageal echocardiography remains superior to contrast-enhanced cardiac magnetic resonance imaging for the diagnosis of patent foramen ovale. (21193485)
2011
26
Paradoxical embolus caught in transit through a patent foramen ovale. (21158915)
2011
27
Prominent persisting Eustachian valve initiates spontaneous right-to-left shunt and paradoxical embolism in a patient with patent foramen ovale. (21472407)
2011
28
Patent foramen ovale and recurrent transient neurological symptoms: a case report and review of literature. (21721458)
2011
29
A giant broccoli-like thrombus secondary to patent foramen ovale. (21827989)
2011
30
The incidence of peripheral arterial embolism in association with a patent foramen ovale (right-to-left shunt). (21637396)
2011
31
The difficulty of choosing between two risks: laparoscopic or open cholecystectomy in the presence of a large patent foramen ovale. (21377089)
2011
32
Recurrent cerebral ischemia in medically treated patent foramen ovale: a meta-analysis. (21768601)
2011
33
Diagnosis and quantification of patent foramen ovale. Which is the reference technique? Simultaneous study with transcranial Doppler, transthoracic and transesophageal echocardiography. (21277667)
2011
34
Higher LA pressure may prevent opening of patent foramen ovale in acute ischemic stroke patients with atrial fibrillation. (21345454)
2011
35
Usefulness of intravenously administered fluid replenishment for detection of patent foramen ovale by transesophageal echocardiography. (20854974)
2010
36
Patent foramen ovale among patients with mild chronic obstructive pulmonary disease and unexplained hypoxia. (20345439)
2010
37
Acute pulmonary embolism and a patent foramen ovale: analysis of atrial right-to-left shunting by biphasic transcardiopulmonary thermodilution curves. (20650385)
2010
38
Recurrence of cryptogenic stroke or TIA in patients with patent foramen ovale successfully treated by using different kind of percutaneous occluder devices: five-year follow-up. (20938409)
2010
39
Device closure of residual shunt after percutaneous closure of patent foramen ovale. (20142199)
2010
40
Biodisk: a new device for closure of patent foramen ovale: a feasibility study in swine. (20432391)
2010
41
Diagnosing patent foramen ovale: too little or too much? (20394895)
2010
42
Patent foramen ovale and mechanical ventilation. (20609328)
2010
43
Do common prothrombotic mutations influence the risk of cerebral ischaemia in patients with patent foramen ovale? Systematic review and meta-analysis. (19404532)
2009
44
Prothrombotic mutations as risk factors for cryptogenic ischemic cerebrovascular events in young subjects with patent foramen ovale. (17525392)
2007
45
Patent foramen ovale or pulmonary arteriovenous malformation: an appeal for diagnostic accuracy. (17625077)
2007
46
Quantitative trait loci modifying cardiac atrial septal morphology and risk of patent foramen ovale in the mouse. (16484617)
2006
47
Transcatheter treatment of atrial septal aneurysm associated with patent foramen ovale for prevention of recurrent paradoxical embolism in high-risk patients. (15680715)
2005
48
Clinical and imaging findings in cryptogenic stroke patients with and without patent foramen ovale: the PFO-ASA Study. Atrial Septal Aneurysm. (11872892)
2002
49
An increased frequency of patent foramen ovale in patients with transient global amnesia. Analysis of 53 consecutive patients. (8660151)
1996
50
Patent foramen ovale, atrial septal aneurysm and ischaemic stroke in young adults. (8070468)
1994

Genetic Variations for Patent Foramen Ovale

Expression for genes affiliated with Patent Foramen Ovale

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Patent Foramen Ovale

Search GEO for disease gene expression data for Patent Foramen Ovale.

Pathways for genes affiliated with Patent Foramen Ovale

Sources:
54Reactome, 12EMD Millipore, 38NCBI BioSystems Database, 52QIAGEN, 53R&D Systems, 30KEGG
See all sources

Compounds for genes affiliated with Patent Foramen Ovale

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 2BitterDB, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Patent Foramen Ovale according to GeneCards/GeneDecks:

(show top 50)    (show all 99)
idCompoundScoreTop Affiliating Genes
1coumarins4510.5APOH
2warfarin45 50 11 2413.1APOH, FGA, SERPINC1
3inogatran4510.0SERPINC1, F2, F5
4ecarin4510.0F5, F2, SERPINC1
5nafamostat mesilate4510.0SERPINC1, FGA, F5
6danaparoid459.9F5, SERPINC1, F2
7ximelagatran45 1110.9F5, SERPINC1, F2
8kaolin459.9APOH, F2, F12, F5
911-dehydrothromboxane b2459.9F2, APOH, FGA
10desogestrel45 1110.9F2, F5, SERPINC1
11gestodene45 1110.8F5, F2, SERPINC1
12hirugen459.8FGA, F5, F2, SERPINC1
13heparinoids459.7F5, F13A1, F2, SERPINC1
14coumarin45 2 50 2412.7F5, SERPINC1, F2, FGA
15gabexate mesilate459.7F5, SERPINC1, PLAT
16batroxobin459.7PLAT, FGA, F5, F2
17tranexamic acid45 1110.6PLAT, F2, SERPINC1
18spectrozyme459.6SERPINC1, F5, F2, PLAT
19serine459.6F12, NKX2-5, NKX2-1, FGA
20fondaparinux459.6F5, PLAT, SERPINC1, F2
21ptca459.6APOH, FGA, PLAT
22protamine sulfate459.6PLAT, F2, F5, SERPINC1
23fibrinopeptide a459.6PLAT, SERPINC1, FGA, F2
24tirofiban45 1110.6SERPINC1, PLAT, F2
25ristocetin459.6F5, F2, PLAT, SERPINC1
26aprotinin45 1110.6F5, PLAT, SERPINC1, FGA
27ticlopidine45 1110.6APOH, FGA, PLAT, SERPINC1
28ppack459.5SERPINC1, PLAT, F2, FGA
29levonorgestrel45 60 29 1112.5F5, PLAT, SERPINC1, F2
30epsilon aminocaproic acid459.5SERPINC1, PLAT, F2
31desmopressin45 60 29 1112.5F5, SERPINC1, PLAT, F2
32heparin45 29 11 2412.5F12, APOH, MTHFR, F13A1, FGA
33dermatan sulfate459.5F5, F2, PLAT, SERPINC1
34pge1459.4FGA, F2, APOH, PLAT, F5
35ancrod459.4F5, F2, SERPINC1, PLAT, FGA
36bivalirudin45 1110.4SERPINC1, PLAT, FGA, F5, F2
37argatroban45 1110.4SERPINC1, F2, FGA, F5, PLAT
38hirudin459.3SERPINC1, PLAT, F2, FGA, F5
39protamine459.3SERPINC1, PLAT, FGA, F5, F2
40diltiazem45 29 1111.3SERPINC1, PLAT, F2
41p002459.2PLAT, MTHFR, F5, APOH
42abciximab45 1110.1F2, SERPINC1, PLAT
43prostacyclin459.0PLAT, APOH, FGA, F5, EDNRA, SERPINC1
44homocysteine45 2410.0PLAT, F2, F5, MTHFR, SERPINC1, APOH
45kininogen458.8SERPINC1, APOH, F5, F12, F2, PLAT
46cholesterol45 29 11 2411.6MTHFR, F5, APOH, FGA, PLAT, EDNRA
47creatinine458.4F5, MTHFR, APOH, EDNRA, FGA, F2
48aspirin45 50 29 2411.2PLAT, F2, FGA, F12, F13A1, MTHFR
49fibrinogen458.2FGA, PLAT, F2, F12, SERPINC1, APOH
50estrogen458.0SERPINC1, F2, NKX2-1, F12, F13A1, MTHFR

GO Terms for genes affiliated with Patent Foramen Ovale

Sources:
16Gene Ontology
See all sources

Cellular components related to Patent Foramen Ovale according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.3F5, F13A1, FGA
2extracellular spaceGO:0056158.4SERPINC1, PLAT, F2, FGA, F12, F5
3extracellular regionGO:0055768.4SERPINC1, PLAT, F2, FGA, F12, F13A1

Biological processes related to Patent Foramen Ovale according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1atrial septum morphogenesisGO:06041310.2NKX2-5, TBX20
2cardiac muscle tissue morphogenesisGO:05500810.1TBX20, NKX2-5
3negative regulation of fibrinolysisGO:05191810.0APOH, F2
4positive regulation of blood coagulationGO:03019410.0F2, F12, APOH
5blood coagulation, intrinsic pathwayGO:00759710.0APOH, F12, F2
6plasminogen activationGO:03163910.0APOH, PLAT
7outflow tract septum morphogenesisGO:00314810.0TBX20, NKX2-5
8blood circulationGO:0080159.9TBX20, MTHFR, F5
9fibrinolysisGO:0427309.8F12, F2, PLAT
10platelet degranulationGO:0025769.7FGA, F13A1, F5
11negative regulation of proteolysisGO:0458619.7PLAT, F2
12positive regulation of release of sequestered calcium ion into cytosolGO:0512819.6F2, EDNRA
13platelet activationGO:0301689.5F2, FGA, F13A1, F5
14blood coagulationGO:0075968.6SERPINC1, F5, F13A1, F12, FGA, F2

Molecular functions related to Patent Foramen Ovale according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.4GOLPH3, EDNRA, F5, F12, NKX2-5, NKX2-1

Products for genes affiliated with Patent Foramen Ovale

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Patent Foramen Ovale

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet