MCID: PTN001
MIFTS: 60

Patent Foramen Ovale malady

Cardiovascular diseases, Fetal diseases, Endocrine diseases categories

Summaries for Patent Foramen Ovale

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63Wikipedia, 32MalaCards
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Wikipedia:63 Atrial septal defect (ASD) is a form of a congenital heart defect that enables blood flow between two... more...

MalaCards: Patent Foramen Ovale, also known as atrial septal defect within oval fossa, is related to migraine and stroke, ischemic. An important gene associated with Patent Foramen Ovale is NKX2-5 (NK2 homeobox 5), and among its related pathways are Platelet activation, signaling and aggregation and Platelet degranulation . The compounds coumarins and warfarin have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and thyroid, and related mouse phenotypes are reproductive system and cardiovascular system.

Aliases & Classifications for Patent Foramen Ovale

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Cardiovascular diseases, Endocrine diseases


Aliases & Descriptions:

patent foramen ovale 8 10 48
atrial septal defect within oval fossa 8 60
foramen ovale patent 8 44
thyroid hormone plasma membrane transport defect 60
ostium secundum type atrial septal defect 8
atrial septal defect ostium secundum 42
persistent, ostium secundum 8
persistent ostium secundum 8
asd ostium secundum type 42
foramen ovale, patent 60
ostium secundum asd 42
defect, patent 8


External Ids:

Disease Ontology8 DOID:13620
NCIt39 C34619
MeSH34 D054092
MESH via Orphanet35 D054092
ICD10 via Orphanet26 Q21.1
SNOMED-CT via Orphanet57 204317008
UMLS via Orphanet61 C0016522

Related Diseases for Patent Foramen Ovale

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17GeneCards, 18GeneDecks
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Diseases related to Patent Foramen Ovale via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 222)
idRelated DiseaseScoreTop Affiliating Genes
1migraine31.6APOH, EDNRA, MTHFR, CLNK, GOLPH3
2stroke, ischemic31.4F5, F2
3pulmonary embolism31.3APOH, F5, MTHFR, F13A1, FGA, F2
4myocardial infarction31.0F5, MTHFR, F13A1, FGA, PLAT, SERPINC1
5hypertension30.9EDNRA, F5, MTHFR, F2, PLAT
6retinal artery occlusion30.9APOH
7ischemia30.7EDNRA, FGA, NMT1, PLAT
8thrombophilia30.7F13A1, F12, FGA, F2, PLAT, SERPINC1
9central retinal artery occlusion30.6PLAT
10acute myocardial infarction30.6FGA, PLAT, SERPINC1
11antiphospholipid syndrome30.6APOH, F5, MTHFR, F2, PLAT, SERPINC1
12atherosclerosis30.6EDNRA, MTHFR, F13A1, FGA, PLAT, SERPINC1
13congenital heart defect30.5EDNRA, MTHFR, F12, NKX2-5, F2
14branch retinal artery occlusion30.4F5
15sickle cell disease30.4FGA
16primary pulmonary hypertension30.4FGA
17obesity30.4EDNRA
18respiratory failure30.4SERPINC1, NKX2-1
19cerebrovascular disease30.4F12, F13A1, MTHFR, APOH
20protein c deficiency30.4APOH, F5, MTHFR, F2, SERPINC1
21protein s deficiency30.3APOH, F5, MTHFR, FGA, F2, SERPINC1
22hyperhomocysteinemia30.3APOH, F5, MTHFR, F2, PLAT, SERPINC1
23cerebritis10.9
24migraine with aura10.8
25retinitis10.6
26thyroid hormone plasma membrane transport defect10.6
27endocarditis10.6
28atrial septal defect 810.5
29arteriovenous fistula10.4
30acute cor pulmonale10.4
31mitral valve prolapse10.4
32migraine without aura10.4
33noonan syndrome10.4
34aortic atherosclerosis10.4
35aortic aneurysm10.4
36glanzmann's thrombasthenia10.4
37takayasu's arteritis10.4
38atrioventricular septal defect10.4
39congenital diaphragmatic hernia10.4
40atrial heart septal defect10.4
41urea cycle disorder10.4
42hereditary folate malabsorption10.4
43zap70-related severe combined immunodeficiency10.4
44acro-pectoro-renal field defect10.4
45ankle defects short stature10.4
46axial mesodermal dysplasia spectrum10.4
47branchial arch defects10.4
48cardioskeletal syndrome kuwaiti type10.4
49sacral defect with anterior meningocele10.4
50caudal regression syndrome10.4

Graphical network of the top 20 diseases related to Patent Foramen Ovale:



Diseases related to patent foramen ovale

Clinical Features for Patent Foramen Ovale

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Drugs & Therapeutics for Patent Foramen Ovale

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Patent Foramen Ovale

Genetic Tests for Patent Foramen Ovale

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Anatomical Context for Patent Foramen Ovale

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32MalaCards
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MalaCards organs/tissues related to Patent Foramen Ovale:

32
Brain, Heart, Thyroid, Liver, Spinal cord, Lung, Testes, Endothelial

Animal Models for Patent Foramen Ovale or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Patent Foramen Ovale:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053899.3MTHFR, POLL, FGA, SERPINC1
2MP:00053858.4EDNRA, F13A1, NKX2-5, NKX2-1, TBX20, FGA
3MP:00053888.4PLAT, F2, NKX2-1, NKX2-5, F13A1, EDNRA
4MP:00053808.4EDNRA, F5, NKX2-5, TBX20, FGA, F2
5MP:00053977.7EDNRA, F13A1, NKX2-5, POLL, FGA, CLNK
6MP:00036317.4EDNRA, F5, MTHFR, F12, NKX2-1, FGA
7MP:00053766.4SERPINC1, APOH, EDNRA, F5, MTHFR, F13A1
8MP:00107686.3F13A1, MTHFR, F5, EDNRA, APOH, NKX2-5

Publications for Patent Foramen Ovale

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50PubMed
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Articles related to Patent Foramen Ovale:

(show top 50)    (show all 582)
idTitleAuthorsYear
1
Very long-term follow-up after percutaneous closure of patent foramen ovale. (24429213)
2014
2
Management of the stroke patient with patent foramen ovale: new insights and persistent questions in the wake of recent randomized trials. (23715857)
2013
3
Patent foramen ovale and atrial septal aneurysm can cause ischemic stroke in patients with antiphospholipid syndrome. (22836909)
2013
4
Embolization of patent foramen ovale closure devices: incidence, role of imaging in identification, potential causes, and management. (24082375)
2013
5
Transcatheter patent foramen ovale closure versus medical therapy for cryptogenic stroke: a meta-analysis of randomized clinical trials. (24330204)
2013
6
Recurrent events after percutaneous closure of patent foramen ovale. (22707325)
2013
7
Branch retinal artery occlusion in a patient with patent foramen ovale. (23825714)
2013
8
Three-dimensional transesophageal echocardiographic evaluation of a patent foramen ovale accompanied with interatrial septal space. (23128550)
2013
9
Shunt volume dynamics in stroke patients with patent foramen ovale. (23743402)
2013
10
Is transcatheter closure better than medical therapy for cryptogenic stroke with patent foramen ovale? A meta-analysis of randomised trials. (24035325)
2013
11
Device closure of patent foramen ovale in cryptogenic stroke: Still stuck in hamlet mode. (24030956)
2013
12
Prevalence of patent foramen ovale with right-to-left shunting in dogs with pulmonic stenosis. (22151278)
2012
13
Heart-brain signaling in patent foramen ovale-related stroke: differential plasma proteomic expression patterns revealed with a 2-pass liquid chromatography-tandem mass spectrometry discovery workflow. (23147404)
2012
14
Periprocedural and late complications after percutaneous closure of patent foramen ovale: a single centre experience]. (22623240)
2012
15
A model of multi-disciplinary approach to the diagnosis and treatment of young patients with cryptogenic stroke and patent foramen ovale. (22348793)
2012
16
Stroke due to late device thrombosis following successful percutaneous patent foramen ovale closure. (21953702)
2012
17
Pupil-sparing complete third nerve palsy from cryptogenic midbrain stroke in an otherwise-healthy young adult with patent foramen ovale. (22623866)
2012
18
Management of patent foramen ovale in cryptogenic stroke. (22455084)
2012
19
Can patent foramen ovale affect rehabilitation? The uncommon association of platypnea-orthodeoxia syndrome and stroke. (21468677)
2011
20
Percutaneous patent foramen ovale closure using Helex and Amplatzer devices without intraprocedural echocardiographic guidance. (21114532)
2011
21
Patent foramen ovale does not have a negative impact on early outcomes in patients undergoing liver transplantation. (20156223)
2011
22
Embolic renal infarct, patent foramen ovale and coronary artery dissection: a strange case of cardio-renal connection. (21241977)
2011
23
Cryptogenic stroke and patent foramen ovale. (22810035)
2011
24
Prevalence of patent foramen ovale in a consecutive cohort of 261 patients undergoing routine "coronary" 64-multi-detector cardiac computed tomography. (22347746)
2011
25
Ascending aortic aneurysm and patent foramen ovale: a rare cause of platypnea-orthodeoxia. (21815525)
2011
26
Late left atrial thrombosis of an Amplatzer patent foramen ovale occluder. (21724200)
2011
27
Short-Term and Two-Year Rate of Recurrent Cerebrovascular Events in Patients with Acute Cerebral Ischemia of Undetermined Aetiology, with and without a Patent Foramen Ovale. (22389838)
2011
28
Experimental study of the Spidera8c patent foramen ovale occluder. (21576943)
2011
29
Device closure of patent foramen ovale--do similar devices achieve similar results? (21433274)
2011
30
Transcranial doppler quantification of residual shunt after percutaneous patent foramen ovale closure: efficacy of the GORE(Ar) HELEX septal occluder. (21492220)
2011
31
Increased incidence of interatrial block in younger adults with cryptogenic stroke and patent foramen ovale. (22566981)
2011
32
Late cardiac perforation after transcatheter closure of patent foramen ovale mimicking acute type a aortic dissection. (20417804)
2010
33
Microemboli may link spreading depression, migraine aura, and patent foramen ovale. (20225282)
2010
34
The Coherex FlatStent: an advance in patent foramen ovale closure. (20214425)
2010
35
Contrast transesophageal echocardiography using the Acunav ultrasound catheter through the mouth way as a guide to percutaneous closure of patent foramen ovale. (20485235)
2010
36
A huge thrombus trapped in the patent foramen ovale. (20865455)
2010
37
Posterior spinal artery infarct due to patent foramen ovale: a case report. (20147870)
2010
38
Unusual treatment of patent foramen ovale after pneumonectomy. (20356992)
2010
39
The BioSTAR(r) device versus the CardioSEAL(r) device in patent foramen ovale closure: comparison of mid-term efficacy and safety. (20884438)
2010
40
Letter by Bhindi and Ormerod regarding article, "Lack of association between migraine headache and patent foramen ovale: results of a case-control study". (21156652)
2010
41
No indication for patent foramen ovale closure in migraine. (19949472)
2009
42
Safety and long-term results of patent foramen ovale transcatheter closure in patients with thrombophilia. (19513009)
2009
43
Undiagnosed patent foramen ovale presenting as retinal artery occlusion-an emerging association. (20309413)
2009
44
Thrombus entrapped in a patent foramen ovale, causing only vague symptoms. (20200458)
2009
45
Infective endocarditis in the setting of infundibular-valvular pulmonary stenosis with incomplete cor triatriatum dextrum and patent foramen ovale. (17692958)
2008
46
Patent foramen ovale and atrial septal aneurysm in cryptogenic stroke. (17344571)
2007
47
Cases from the aerospace medicine residents' teaching file. Transient ischemic attack in an aviator with patent foramen ovale and Factor V Leiden. (14692478)
2003
48
Patent foramen ovale, atrial septal aneurysm, and recurrent stroke. (11973856)
2002
49
Refractory hypoxemia in inferior myocardial infarction from right-to-left shunting through a patent foramen ovale: a case report and review of the literature. (7834939)
1994
50
The clinical syndrome produced by valvular pulmonic stenosis with intact ventricular septum and patent foramen ovale. (15420553)
1950

Genetic Variations for Patent Foramen Ovale

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Expression for genes affiliated with Patent Foramen Ovale

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Patent Foramen Ovale

Search GEO for disease gene expression data for Patent Foramen Ovale.

Pathways for genes affiliated with Patent Foramen Ovale

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Sources:
53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN, 52R&D Systems, 29KEGG
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Compounds for genes affiliated with Patent Foramen Ovale

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 2BitterDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Patent Foramen Ovale according to GeneCards/GeneDecks:

(show top 50)    (show all 99)
idCompoundScoreTop Affiliating Genes
1coumarins4410.5APOH
2warfarin44 49 11 2413.1APOH, FGA, SERPINC1
3inogatran4410.0SERPINC1, F2, F5
4ecarin4410.0SERPINC1, F2, F5
5nafamostat mesilate4410.0F5, FGA, SERPINC1
6danaparoid4410.0F5, F2, SERPINC1
711-dehydrothromboxane b2449.9APOH, FGA, F2
8ximelagatran44 1110.9SERPINC1, F2, F5
9kaolin449.9APOH, F5, F12, F2
10desogestrel44 1110.9F5, F2, SERPINC1
11gestodene44 1110.8F5, F2, SERPINC1
12hirugen449.8SERPINC1, F2, FGA, F5
13heparinoids449.7F5, F13A1, F2, SERPINC1
14coumarin44 2 49 2412.7F5, FGA, F2, SERPINC1
15gabexate mesilate449.7F5, PLAT, SERPINC1
16batroxobin449.7F5, FGA, F2, PLAT
17tranexamic acid44 1110.6SERPINC1, PLAT, F2
18spectrozyme449.6F5, F2, PLAT, SERPINC1
19serine449.6F12, NKX2-5, NKX2-1, FGA
20fondaparinux449.6SERPINC1, PLAT, F2, F5
21ptca449.6PLAT, FGA, APOH
22protamine sulfate449.6F5, F2, PLAT, SERPINC1
23fibrinopeptide a449.6FGA, F2, PLAT, SERPINC1
24tirofiban44 1110.6SERPINC1, PLAT, F2
25ristocetin449.6F5, F2, PLAT, SERPINC1
26aprotinin44 1110.6F5, FGA, PLAT, SERPINC1
27ticlopidine44 1110.6SERPINC1, PLAT, FGA, APOH
28ppack449.5FGA, F2, PLAT, SERPINC1
29levonorgestrel44 59 28 1112.5F5, F2, PLAT, SERPINC1
30epsilon aminocaproic acid449.5F2, PLAT, SERPINC1
31desmopressin44 59 28 1112.5F5, F2, PLAT, SERPINC1
32heparin44 28 11 2412.5APOH, MTHFR, F13A1, F12, FGA
33dermatan sulfate449.5F5, F2, PLAT, SERPINC1
34pge1449.4APOH, F5, FGA, F2, PLAT
35ancrod449.4F5, FGA, F2, PLAT, SERPINC1
36bivalirudin44 1110.4F5, FGA, F2, PLAT, SERPINC1
37argatroban44 1110.4F5, FGA, F2, PLAT, SERPINC1
38hirudin449.3F5, FGA, F2, PLAT, SERPINC1
39protamine449.3F5, FGA, F2, PLAT, SERPINC1
40diltiazem44 28 1111.3SERPINC1, PLAT, F2
41p002449.2APOH, F5, MTHFR, PLAT
42abciximab44 1110.1F2, PLAT, SERPINC1
43prostacyclin449.0APOH, EDNRA, F5, FGA, PLAT, SERPINC1
44homocysteine44 2410.0APOH, F5, MTHFR, F2, PLAT, SERPINC1
45kininogen448.8APOH, F5, F13A1, F12, F2, PLAT
46cholesterol44 28 11 2411.6PLAT, FGA, MTHFR, F5, EDNRA, APOH
47creatinine448.4APOH, EDNRA, F5, MTHFR, FGA, F2
48aspirin44 49 28 2411.2SERPINC1, APOH, F5, MTHFR, F13A1, F12
49fibrinogen448.2APOH, F5, MTHFR, F13A1, F12, FGA
50estrogen448.0APOH, EDNRA, F5, MTHFR, F13A1, F12

GO Terms for genes affiliated with Patent Foramen Ovale

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16Gene Ontology
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Cellular components related to Patent Foramen Ovale according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.3F5, F13A1, FGA
2extracellular spaceGO:0056158.4SERPINC1, PLAT, F2, FGA, F12, F5
3extracellular regionGO:0055768.4SERPINC1, PLAT, F2, FGA, F12, F13A1

Biological processes related to Patent Foramen Ovale according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1atrial septum morphogenesisGO:06041310.2NKX2-5, TBX20
2cardiac muscle tissue morphogenesisGO:05500810.1TBX20, NKX2-5
3negative regulation of fibrinolysisGO:05191810.0APOH, F2
4positive regulation of blood coagulationGO:03019410.0F2, F12, APOH
5blood coagulation, intrinsic pathwayGO:00759710.0APOH, F12, F2
6plasminogen activationGO:03163910.0APOH, PLAT
7outflow tract septum morphogenesisGO:00314810.0TBX20, NKX2-5
8blood circulationGO:0080159.9TBX20, MTHFR, F5
9fibrinolysisGO:0427309.8F12, F2, PLAT
10platelet degranulationGO:0025769.7FGA, F13A1, F5
11negative regulation of proteolysisGO:0458619.7PLAT, F2
12positive regulation of release of sequestered calcium ion into cytosolGO:0512819.6F2, EDNRA
13platelet activationGO:0301689.5F2, FGA, F13A1, F5
14blood coagulationGO:0075968.6SERPINC1, F5, F13A1, F12, FGA, F2

Molecular functions related to Patent Foramen Ovale according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.4GOLPH3, EDNRA, F5, F12, NKX2-5, NKX2-1

Products for genes affiliated with Patent Foramen Ovale

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  • Antibodies
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Sources for Patent Foramen Ovale

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet