MCID: PTN001
MIFTS: 61

Patent Foramen Ovale malady

Rare diseases, Cardiovascular diseases, Fetal diseases, Endocrine diseases categories

Summaries for Patent Foramen Ovale

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66Wikipedia, 34MalaCards
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Wikipedia:66 Atrial septal defect (ASD) is a form of a congenital heart defect that enables blood flow between two... more...

MalaCards: Patent Foramen Ovale, also known as atrial septal defect within oval fossa, is related to pulmonary embolism and thromboembolism. An important gene associated with Patent Foramen Ovale is NKX2-5 (NK2 homeobox 5), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and HOP Signaling. The compounds mucicarmine and coumarins have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and thyroid, and related mouse phenotypes are muscle and respiratory system.

Aliases & Classifications for Patent Foramen Ovale

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9Disease Ontology, 11DISEASES, 50Orphanet, 46Novoseek, 63UMLS, 44NIH Rare Diseases, 59SNOMED-CT, 36MeSH, 41NCIt, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:



Aliases & Descriptions:

patent foramen ovale 9 11 50
atrial septal defect within oval fossa 9 63
foramen ovale patent 9 46
thyroid hormone plasma membrane transport defect 63
atrial septal defect, ostium secundum type 50
ostium secundum type atrial septal defect 9
atrial septal defect ostium secundum 44
persistent, ostium secundum 9
persistent ostium secundum 9
asd, ostium secundum type 50
asd ostium secundum type 44
foramen ovale, patent 63
ostium secundum asd 44
defect, patent 9


External Ids:

Disease Ontology9 DOID:13620
MeSH36 D054092
NCIt41 C34619
MESH via Orphanet37 D054092
ICD10 via Orphanet27 Q21.1
SNOMED-CT via Orphanet60 204317008, 204315000, 204318003
UMLS via Orphanet64 C0016522, C0344724

Related Diseases for Patent Foramen Ovale

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18GeneCards, 19GeneDecks
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Diseases related to Patent Foramen Ovale via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary embolism31.5APOH, F5, FGA
2thromboembolism31.3F12, FGA, APOH, F5
3myocardial infarction31.1F5, FGA, GATA4
4retinal artery occlusion31.1APOH
5thrombophilia30.9F5, APOH, FGA, F12
6antiphospholipid syndrome30.8APOH, F5
7venous thrombosis30.7FGA, APOH, F12, F5
8noonan syndrome30.6NKX2-5, GATA4, ACTC1, MYH6
9cerebrovascular disease30.5APOH, F12
10congenital heart disease30.5GATA4, NKX2-5
11hyperhomocysteinemia30.5F5, APOH
12ventricular septal defect30.4NKX2-5
13aneurysm11.1
14atrial septal aneurysm11.1
15migraine11.1
16cerebritis10.9
17headache10.8
18migraine with aura10.7
19obstructive sleep apnea10.7
20hypertension10.7
21sleep apnea10.7
22retinitis10.6
23endocarditis10.6
24ischemia10.5
25pulmonic stenosis10.5
26transposition of the great arteries10.5
27arteriovenous fistula10.4
28acute cor pulmonale10.4
29aortic atherosclerosis10.4
30central retinal artery occlusion10.4
31acute myocardial infarction10.4
32atherosclerosis10.4
33cor triatriatum10.4
34hemiplegic migraine10.4
35hypoxia10.4
36cor pulmonale10.4
37persistent eustachian valve10.4
38sternal cleft10.4
39myoma10.3
40klippel-trenaunay syndrome10.3
41mitral valve prolapse10.3
42polydactyly10.3
43neuronitis10.3
44hereditary spherocytosis10.3
45hemoglobinuria10.3
46hypoplastic left heart syndrome10.3
47aortic valve prolapse10.3
48pulmonary edema10.3
49migraine without aura10.3
50arteriovenous malformation10.3

Graphical network of the top 20 diseases related to Patent Foramen Ovale:



Diseases related to patent foramen ovale

Symptoms for Patent Foramen Ovale

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Drugs & Therapeutics for Patent Foramen Ovale

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Patent Foramen Ovale

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Anatomical Context for Patent Foramen Ovale

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34MalaCards
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MalaCards organs/tissues related to Patent Foramen Ovale:

34
Brain, Heart, Thyroid, Spinal cord, Liver, Lung, Testes, Endothelial

Animal Models for Patent Foramen Ovale or affiliated genes

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38MGI
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Publications for Patent Foramen Ovale

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53PubMed
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Articles related to Patent Foramen Ovale:

(show top 50)    (show all 576)
idTitleAuthorsYear
1
Is closure of patent foramen ovale to prevent ischaemic stroke ever justified? (24167203)
2013
2
Neonatal systemic thromboembolism secondary to ductus arteriosus aneurysm and patent foramen ovale. (21801317)
2013
3
Determination of the Optimum Number of Cardiac Cycles to Differentiate Intra-Pulmonary Shunt and Patent Foramen Ovale by Saline Contrast Two- and Three-Dimensional Echocardiography. (24028319)
2013
4
Current evidence for closure of a patent foramen ovale for cryptogenic stroke prevention. (24373020)
2013
5
Thrombus formation in a patent foramen ovale. (23528287)
2013
6
Death by patent foramen ovale in a soccer player. (23468450)
2013
7
Patent foramen ovale in severe obstructive sleep apnea: clinical features and effects of closure. (22924163)
2013
8
Neuroimaging findings in cryptogenic stroke patients with and without patent foramen ovale. (23339957)
2013
9
Patent Foramen Ovale and Migraine Attacks: A Systematic Review. (24355354)
2013
10
Management of the stroke patient with patent foramen ovale: new insights and persistent questions in the wake of recent randomized trials. (23715857)
2013
11
Neurosurgery in the Semisitting Position in Patients with a Patent Foramen Ovale. (23920299)
2013
12
A systematic review of closure versus medical therapy for preventing recurrent stroke in patients with patent foramen ovale and cryptogenic stroke or transient ischemic attack. (24300230)
2013
13
Follow-up to 'Cholecystectomy in the presence of a large patent foramen ovale: laparoscopic or open?'. (23541851)
2013
14
Patent foramen ovale and atrial septal aneurysm can cause ischemic stroke in patients with antiphospholipid syndrome. (22836909)
2013
15
Updating the evidence on patent foramen ovale closure versus medical therapy in patients with cryptogenic stroke: aa8^systematic review and comprehensive meta-analysis of 2,303 patients from three randomised trials and 2,231 patients from 11 observational studies. (24240356)
2013
16
Effectiveness of percutaneous closure of patent foramen ovale for hypoxemia. (23871675)
2013
17
Multidisciplinary management of patent foramen ovale (PFO) and cryptogenic stroke/TIA. (24082787)
2013
18
Incidence of patent foramen ovale and migraine headache in adults with congenital heart disease with no known cardiac shunts. (22927216)
2013
19
Platypnoea-orthodeoxia in an elderly man with patent foramen ovale and dilated ascending aorta. (22089080)
2012
20
Platypnea-orthodeoxia syndrome related to right hemidiaphragmatic elevation and a 'stretched' patent foramen ovale. (23230257)
2012
21
Patent foramen ovale, dialysis and microembolization. (22487266)
2012
22
Secondary stroke prevention: patent foramen ovale, aortic plaque, and carotid stenosis. (22422912)
2012
23
Simultaneous myocardial infarction and ischaemic stroke secondary to paradoxical emboli through a patent foramen ovale. (22930890)
2012
24
Stress-induced cardiomyopathy after patent foramen ovale closure: what role did anesthesia play? (22633744)
2012
25
Prevalence of patent foramen ovale with right-to-left shunting in dogs with pulmonic stenosis. (22151278)
2012
26
Focal neurological deficit with tricuspid endocarditis and patent foramen ovale. (22878350)
2012
27
Transcranial Doppler quantification of residual shunt after percutaneous patent foramen ovale closure: correlation of device efficacy with intracardiac anatomic measures. (22364421)
2012
28
Can patent foramen ovale affect rehabilitation? The uncommon association of platypnea-orthodeoxia syndrome and stroke. (21468677)
2011
29
Electrocardiographic changes and arrhythmias following percutaneous atrial septal defect and patent foramen ovale device closure. (21563292)
2011
30
Evaluation of patent foramen ovale in young adults with cryptogenic stroke. (22577450)
2011
31
Transthoracic echocardiography guidance during percutaneous closure of patent foramen ovale. (21967656)
2011
32
Contrast transoesophageal echocardiography remains superior to contrast-enhanced cardiac magnetic resonance imaging for the diagnosis of patent foramen ovale. (21193485)
2011
33
Role of patent foramen ovale in migraine etiology and treatment: a review. (21827543)
2011
34
Explantation of patent foramen ovale closure devices: a multicenter survey. (21596333)
2011
35
Risk and fate of residual interatrial shunting after transcatheter closure of patent foramen ovale: a long term follow up study. (21345765)
2011
36
Interatrial septal aneurysm and patent foramen ovale: diagnosis and dynamic evaluation with electrocardiogram-gated multidetector-row computed tomography imaging. (21079517)
2011
37
Usefulness of intravenously administered fluid replenishment for detection of patent foramen ovale by transesophageal echocardiography. (20854974)
2010
38
Late cardiac perforation after transcatheter closure of patent foramen ovale mimicking acute type a aortic dissection. (20417804)
2010
39
The association of patent foramen ovale transcatheter closure and psychological well-being. (20089005)
2010
40
Patent foramen ovale among patients with mild chronic obstructive pulmonary disease and unexplained hypoxia. (20345439)
2010
41
Acute myocardial infarction involving two coronary arteries due to a patent foramen ovale. (20676784)
2010
42
Patent foramen ovale and obstructive sleep apnea: a new association? (20451427)
2010
43
A case of platypnea-orthodeoxia syndrome caused by the interaction between the presence of corrected transposition of the great arteries and patent foramen ovale. (18706706)
2010
44
Paradoxical emboli--clinical importance of transcranial Doppler for detection of patent foramen ovale. (21443152)
2010
45
A third treatment option for entrapped thrombus in patent foramen ovale. (20548835)
2010
46
A gain-of-function TBX20 mutation causes congenital atrial septal defects, patent foramen ovale and cardiac valve defects. (19762328)
2010
47
No indication for patent foramen ovale closure in migraine. (19949472)
2009
48
Do common prothrombotic mutations influence the risk of cerebral ischaemia in patients with patent foramen ovale? Systematic review and meta-analysis. (19404532)
2009
49
That balloon atrial septostomy is associated with preoperative stroke in neonates with transposition of the great arteries is another powerful argument in favor of therapeutic closure of every patent foramen ovale. (16828611)
2006
50
Atrial septal aneurysm plus a patent foramen ovale. A predisposing factor for paradoxical embolism and refractory hypoxemia during pulmonary embolism. (8797439)
1996

Variations for Patent Foramen Ovale

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Expression for genes affiliated with Patent Foramen Ovale

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Patent Foramen Ovale

Search GEO for disease gene expression data for Patent Foramen Ovale.

Pathways for genes affiliated with Patent Foramen Ovale

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Sources:
51PathCards, 54QIAGEN, 56Reactome, 39NCBI BioSystems Database, 61Thomson Reuters, 31KEGG, 55R&D Systems
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Pathways related to Patent Foramen Ovale according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0NKX2-5, GATA4
210.0GATA4, NKX2-5
39.9GATA6, GATA4
4
Show member pathways
9.7GATA6, GATA4, NKX2-5
59.4GATA4, TBX20, NKX2-5, GATA6
6
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility61
Cytoskeleton remodeling Integrin outside in signaling61
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases61
Cell adhesion Tight junctions61
Development MAG dependent inhibition of neurite outgrowth61
9.3MYH6, ACTC1, NKX2-1
79.1GATA4, TBX20, NKX2-5, ACTC1, MYH6
8
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
8.8F5, FGA, F12
9
Show member pathways
8.8F12, F5, FGA
10
Show member pathways
8.4F12, FGA, F5, TLL1
11
Show member pathways
8.2GATA4, F12, FGA, GATA6, F5

Compounds for genes affiliated with Patent Foramen Ovale

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 3BitterDB, 52PharmGKB
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Compounds related to Patent Foramen Ovale according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1mucicarmine4610.0ACTC1, NKX2-1
2coumarins469.8APOH, F5
3b 723469.8NKX2-1, ACTC1
4methanol46 2510.7ACTC1, APOH
5hirugen469.6F5, FGA
6nafamostat mesilate469.6F5, FGA
7batroxobin469.6FGA, F5
8cardiolipin46 1210.6APOH, F5
9ancrod469.6F5, FGA
10bivalirudin46 1210.6FGA, F5
11argatroban46 1210.5F5, FGA
12kaolin469.5APOH, F5, F12
1311-dehydrothromboxane b2469.5APOH, FGA
14kininogen469.5F12, APOH, F5
15cacl2469.5F5, FGA
166-ketoprostaglandin f1alpha469.4FGA, APOH
17ticlopidine46 1210.4FGA, APOH
18polyacrylamide469.4APOH, MYH6, F5
19ptca469.4APOH, FGA
20progesterone46 30 62 25 1213.3GATA4, ACTC1, APOH, F5
21coumarin46 3 52 2512.3FGA, F5
22phosphatidylethanolamine46 1210.2APOH, F5
23hirudin469.2F5, FGA
24warfarin46 52 25 1212.1F5, APOH, FGA
25malondialdehyde469.1F5, FGA, APOH
26pge1469.0FGA, APOH, F5
27endotoxin469.0FGA, APOH, F5
28prostacyclin468.9APOH, FGA, F5
29nitric oxide46 25 1210.9GATA4, APOH, NKX2-5, F5
30retinoic acid46 259.7GATA4, GATA6, F5, NKX2-1, ACTC1, MYH6
31creatinine468.7ACTC1, APOH, F5, FGA
32aspirin46 52 30 2511.7APOH, F12, F5, FGA
33fibrinogen468.6F12, FGA, F5, APOH
34zinc46 259.6GATA6, NKX2-1, GATA4, APOH, F12, NKX2-5
35cholesterol46 30 25 1211.6F5, APOH, FGA, GATA6
36heparin46 30 25 1211.6FGA, F5, F12, APOH
37steroid468.5GATA6, NKX2-1, APOH, GATA4, ACTC1, F5
38estrogen468.1F12, APOH, ACTC1, NKX2-1, F5, GATA4
39calcium46 52 25 1211.0FGA, GATA4, F5, ACTC1, MYH6, APOH
40serine467.8F12, NKX2-5, NKX2-1, F5, GATA4, FGA

GO Terms for genes affiliated with Patent Foramen Ovale

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17Gene Ontology
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Cellular components related to Patent Foramen Ovale according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sarcomereGO:0300179.9ACTC1, MYH6
2transcription factor complexGO:0056679.3GATA6, NKX2-1, NKX2-5
3extracellular spaceGO:0056158.0FGA, F5, ACTC1, APOH, F12
4nucleusGO:0056347.3CITED2, POLL, MYH6, NKX2-5, NKX2-1, TBX20

Biological processes related to Patent Foramen Ovale according to GeneCards/GeneDecks:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1intestinal epithelial cell differentiationGO:06057510.3GATA4, GATA6
2cardiac right ventricle morphogenesisGO:00321510.3TBX20, GATA4
3embryonic heart tube left/right pattern formationGO:06097110.3NKX2-5, CITED2
4endoderm formationGO:00170610.3TBX20, GATA4
5cardiac muscle hypertrophy in response to stressGO:01489810.2GATA6, GATA4
6adult heart developmentGO:00751210.2NKX2-5, MYH6
7endocardial cushion developmentGO:00319710.2GATA4, CITED2
8cardiac muscle cell differentiationGO:05500710.2GATA6, NKX2-5
9atrial septum morphogenesisGO:06041310.1NKX2-5, TBX20, GATA4
10outflow tract septum morphogenesisGO:00314810.1NKX2-5, TBX20, GATA6
11positive regulation of cardioblast differentiationGO:05189110.1GATA4, GATA6, NKX2-5
12cardiac muscle tissue morphogenesisGO:05500810.1ACTC1, TBX20, NKX2-5
13positive regulation of cardiac muscle cell proliferationGO:06004510.1TBX20, GATA6, GATA4
14ventricular septum morphogenesisGO:06041210.1NKX2-5, CITED2
15Clara cell differentiationGO:06048610.1GATA6, NKX2-1
16lung saccule developmentGO:06043010.0NKX2-1, GATA6
17sarcomere organizationGO:04521410.0NKX2-5, MYH6
18Type II pneumocyte differentiationGO:06051010.0NKX2-1, GATA6
19BMP signaling pathwayGO:03050910.0GATA4, NKX2-5, MYH6
20canonical Wnt signaling pathwayGO:06007010.0NKX2-5, MYH6, GATA4
21response to estrogenGO:04362710.0CITED2, GATA6, GATA4
22male gonad developmentGO:0085849.9GATA4, GATA6, CITED2
23thyroid gland developmentGO:0308789.9NKX2-5, NKX2-1
24spleen developmentGO:0485369.9NKX2-5, CITED2
25positive regulation of blood coagulationGO:0301949.9F12, APOH
26endoderm developmentGO:0074929.8GATA4, NKX2-1
27heart loopingGO:0019479.8CITED2, TBX20, NKX2-5, GATA4
28blood coagulation, intrinsic pathwayGO:0075979.8APOH, F12
29blood circulationGO:0080159.8TBX20, F5
30muscle filament slidingGO:0300499.8ACTC1, MYH6
31in utero embryonic developmentGO:0017019.7GATA4, GATA6, MYH6
32cardiac muscle contractionGO:0600489.6NKX2-5, ACTC1
33negative regulation of transcription, DNA-templatedGO:0458929.6GATA6, CITED2, TBX20, NKX2-5
34negative regulation of apoptotic processGO:0430669.6NKX2-5, ACTC1, GATA6, CITED2
35positive regulation of transcription, DNA-templatedGO:0458939.4CITED2, NKX2-1, GATA4, NKX2-5
36negative regulation of transcription from RNA polymerase II promoterGO:0001229.2GATA6, NKX2-5, NKX2-1, TBX20, CITED2
37positive regulation of transcription from RNA polymerase II promoterGO:0459449.0CITED2, NKX2-5, NKX2-1, TBX20, GATA6, GATA4
38blood coagulationGO:0075968.6F12, F5, GATA6, FGA, GATA4

Molecular functions related to Patent Foramen Ovale according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription coactivator activityGO:0011059.9TBX20, CITED2
2RNA polymerase II regulatory region sequence-specific DNA bindingGO:0009779.9TBX20, GATA4
3transcription factor bindingGO:0081349.7NKX2-5, GATA4, GATA6
4RNA polymerase II activating transcription factor bindingGO:0011029.6CITED2, TBX20
5chromatin bindingGO:0036829.5GATA4, GATA6, NKX2-5, CITED2
6RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:0037059.4NKX2-1, NKX2-5, GATA6, GATA4
7transcription regulatory region DNA bindingGO:0442129.3NKX2-1, GATA6, GATA4, NKX2-5
8sequence-specific DNA binding transcription factor activityGO:0037008.7CITED2, GATA4, GATA6, TBX20, NKX2-1, NKX2-5
9protein bindingGO:0055156.7F12, APOH, CITED2, NKX2-5, NKX2-1, F5

Products for genes affiliated with Patent Foramen Ovale

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Sources for Patent Foramen Ovale

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet