Patent Foramen Ovale (OSASD) malady

Categories: Rare diseases, Cardiovascular diseases, Fetal diseases

Aliases & Classifications for Patent Foramen Ovale

Aliases & Descriptions for Patent Foramen Ovale:

Name: Patent Foramen Ovale 12 56 14
Foramen Ovale Patent 12 29 52
Foramen Ovale, Patent 42 69
Defect, Patent or Persistent, Ostium Secundum 12
Atrial Septal Defect, Ostium Secundum Type 56
Ostium Secundum Type Atrial Septal Defect 12
Atrial Septal Defect Within Oval Fossa 12
Ostium Secundum Atrial Septal Defect 50
Persistent Ostium Secundum 12
Asd, Ostium Secundum Type 56
Asd Ostium Secundum Type 50
Ostium Secundum Asd 50
Osasd 50


External Ids:

Disease Ontology 12 DOID:13620
ICD10 33 Q21.1
MeSH 42 D054092
NCIt 47 C34619
MESH via Orphanet 43 D054092
UMLS via Orphanet 70 C0016522 C0344724
ICD10 via Orphanet 34 Q21.1
UMLS 69 C0016522

Summaries for Patent Foramen Ovale

NIH Rare Diseases : 50 an ostium secundum atrial septal defect is a type of congenital heart defect called an atrial septal defect (asd). an asd is a hole in the wall (septum) between the two upper chambers of the heart (the atria). asds can be classified by location. an ostium secundum asd is a hole in the center of the atrial septum. normally, the right side of the heart pumps oxygen-poor blood to the lungs, while the left side pumps oxygen-rich blood to the body. an asd allows blood from both sides to mix, causing the heart to work less efficiently. a small hole may not cause any symptoms or problems. a larger hole can eventually cause symptoms such as shortness of breath, respiratory infections, fainting, irregular heart rhythms or fatigue after mild activity. larger asds can also ultimately lead to pulmonary artery hypertension, right ventricular hypertrophy (enlargement); svt, or heart failure. most cases of asd are not inherited and occur by chance. some cases appear to have autosomal dominant inheritance. treatment may not be needed for small asds, which often close on their own. larger asds are typically closed during childhood with open heart surgery or by cardiac catheterization. last updated: 8/4/2016

MalaCards based summary : Patent Foramen Ovale, also known as foramen ovale patent, is related to myocardial infarction and persistent eustachian valve. An important gene associated with Patent Foramen Ovale is NKX2-5 (NK2 Homeobox 5), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Aspirin and Warfarin have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Patent Foramen Ovale

Diseases related to Patent Foramen Ovale via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 191)
id Related Disease Score Top Affiliating Genes
1 myocardial infarction 30.6 F13A1 F2 F5 FGA GATA4 MTHFR
2 persistent eustachian valve 30.5 GATA4 GATA6
3 central retinal artery occlusion 30.5 APOH F2 MTHFR SERPINC1
4 budd-chiari syndrome 30.0 APOH F2 F5 FGA MTHFR SERPINC1
5 influenza 30.0 F2 SERPINC1
6 short stature, developmental delay, and congenital heart defects 11.2
7 mental retardation and distinctive facial features with or without cardiac defects 11.2
8 aneurysm 10.7
9 atrial septal aneurysm 10.7
10 pulmonary embolism 10.6
11 cerebritis 10.5
12 headache 10.5
13 multiple familial trichoepithelioma 10.4 F5 MTHFR
14 med13l syndrome 10.4 APOH F5
15 congenital insensitivity to pain with severe intellectual disability 10.4 F2 F5
16 absence of innominate vein 10.4 F5 MTHFR
17 migraine with aura 10.4
18 achard thiers syndrome 10.4 APOH F5
19 photosensitive epilepsy 10.4 F2 F5 MTHFR
20 hendra virus infection 10.4 APOH F2 F5
21 lung cancer 10.4 APOH F5 MTHFR
22 pancreatic ductal carcinoma 10.4 F2 F5 SERPINC1
23 houlston ironton temple syndrome 10.4 F2 F5 MTHFR
24 villous adenoma 10.4 F2 F5 MTHFR
25 central congenital hypothyroidism 10.4 APOH F5 MTHFR
26 thrombosis 10.4
27 mixed epithelial tumor of ovary 10.4 F2 MTHFR SERPINC1
28 glutathionuria 10.4 APOH F2 MTHFR
29 myosclerosis, congenital 10.4 F5 MTHFR SERPINC1
30 peanut allergy 10.4 F12 F2 SERPINC1
31 neuroaxonal dystrophy 10.4 F2 F5 SERPINC1
32 scn8a-related epilepsy with encephalopathy 10.4 F13A1 F2 MTHFR
33 may-hegglin anomaly 10.4 APOH F2 SERPINC1
34 ductal carcinoma in situ 10.3 F2 MTHFR SERPINC1
35 dystrophic epidermolysis bullosa, nails only 10.3 ACTC1 F13A1
36 czech dysplasia 10.3 APOH F5 SERPINC1
37 alpha-2-plasmin inhibitor deficiency 10.3 F2 MTHFR SERPINC1
38 capillary hemangioma 10.3 F2 MTHFR SERPINC1
39 oral erosive lichen 10.3 ACTC1 F13A1
40 oguchi disease-2 10.3 F2 F5 SERPINC1
41 lubinsky syndrome 10.3 APOH F2 F5 MTHFR
42 supraumbilical midabdominal raphe and facial cavernous hemangiomas 10.3 APOH F2 F5 MTHFR
43 stt3a-cdg and stt3b-cdg 10.3 F5 SERPINC1
44 aminoaciduria 10.3 F5 MTHFR
45 congenital benign spinal muscular atrophy dominant 10.3 GATA4 GATA6
46 ischemic optic neuropathy 10.3 APOH F2 SERPINC1
47 brachyolmia type 3 10.3 MYH6 NKX2-5 TBX5
48 pancreas adenocarcinoma 10.3 F2 MTHFR SERPINC1
49 exophthalmic ophthalmoplegia 10.3 APOH F5 SERPINC1
50 pauciarticular chronic arthritis 10.3 GATA4 GATA6

Graphical network of the top 20 diseases related to Patent Foramen Ovale:

Diseases related to Patent Foramen Ovale

Symptoms & Phenotypes for Patent Foramen Ovale

MGI Mouse Phenotypes related to Patent Foramen Ovale:

44 (show all 14)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.44 ACTC1 CITED2 EDNRA F13A1 F2 F5
2 homeostasis/metabolism MP:0005376 10.43 F2 F5 FGA GATA4 GATA6 MTHFR
3 mortality/aging MP:0010768 10.36 ACTC1 APOH CITED2 EDNRA F13A1 F2
4 growth/size/body region MP:0005378 10.31 GATA6 MTHFR NKX2-1 NKX2-5 TBX20 TBX5
5 embryo MP:0005380 10.25 CITED2 EDNRA F2 TBX20 TBX5 F5
6 hematopoietic system MP:0005397 10.22 GATA4 GATA6 NKX2-5 SERPINC1 TLL1 CITED2
7 digestive/alimentary MP:0005381 10.13 CITED2 EDNRA F2 FGA GATA4 NKX2-1
8 nervous system MP:0003631 10.06 CITED2 EDNRA F12 F2 F5 FGA
9 integument MP:0010771 10.03 EDNRA F2 F5 FGA GATA4 MTHFR
10 muscle MP:0005369 10.02 ACTC1 EDNRA GATA4 GATA6 MYH6 NKX2-5
11 normal MP:0002873 10 ACTC1 CITED2 EDNRA F12 F2 GATA4
12 reproductive system MP:0005389 9.81 F12 F13A1 F2 FGA GATA4 GATA6
13 respiratory system MP:0005388 9.56 CITED2 EDNRA F13A1 F2 GATA4 GATA6
14 skeleton MP:0005390 9.28 FGA GATA4 MTHFR NKX2-1 TBX5 TLL1

Drugs & Therapeutics for Patent Foramen Ovale

Drugs for Patent Foramen Ovale (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
id Name Status Phase Clinical Trials Cas Number PubChem Id
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-78-2 2244
Warfarin Approved Phase 4,Phase 2,Phase 3 81-81-2 6691 54678486
Clopidogrel Approved, Nutraceutical Phase 4,Phase 3,Phase 2 120202-66-6, 113665-84-2 60606
4 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2
5 Analgesics Phase 4,Phase 2,Phase 3
6 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3
7 Anticoagulants Phase 4,Phase 3,Phase 2
8 Antipyretics Phase 4,Phase 2,Phase 3
9 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
10 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
11 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2
12 Antirheumatic Agents Phase 4,Phase 3,Phase 2
13 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2
14 Fibrinolytic Agents Phase 4,Phase 3,Phase 2
Acetaminophen Approved Phase 2, Phase 3 103-90-2 1983
Apixaban Approved Phase 3,Phase 2 503612-47-3 10182969
Dipyridamole Approved Phase 3,Phase 2 58-32-2 3108
Rivaroxaban Approved Phase 3 366789-02-8
19 Antithrombin III Phase 3,Phase 2
20 Antithrombins Phase 3,Phase 2
21 Antivitamins K Phase 3
22 Aspirin, Dipyridamole Drug Combination Phase 3
23 Dabigatran Phase 3
24 Factor Xa Inhibitors Phase 3,Phase 2
25 HIV Protease Inhibitors Phase 3,Phase 2
protease inhibitors Phase 3,Phase 2
27 Serine Proteinase Inhibitors Phase 3,Phase 2
28 Pharmaceutical Solutions Phase 3,Phase 2
29 serine Nutraceutical Phase 3,Phase 2
Polidocanol Approved Phase 2 9002-92-0
Dalteparin Approved Phase 2 9041-08-1
Heparin Approved, Investigational Phase 2 9005-49-6 772 46507594
33 Neurotransmitter Agents Phase 2
34 Anticonvulsants Phase 2
35 Antidepressive Agents Phase 2
36 calcium heparin Phase 2
37 Calcium, Dietary Phase 2
38 Heparin, Low-Molecular-Weight Phase 2
39 Purinergic P2 Receptor Antagonists Phase 2
40 Purinergic P2Y Receptor Antagonists Phase 2
Nitric Oxide Approved 10102-43-9 145068
Vitamin C Approved, Nutraceutical 50-81-7 5785 54670067
Vitamin E Approved, Nutraceutical, Vet_approved 59-02-9 14985
44 Antioxidants
45 Micronutrients
46 Protective Agents
47 Tocopherols
48 Tocotrienols
49 Trace Elements
50 Vitamins

Interventional clinical trials:

(show top 50) (show all 69)
id Name Status NCT ID Phase
1 Device Closure Versus Medical Therapy for Cryptogenic Stroke Patients With High-Risk Patent Foramen Ovale (DEFENSE-PFO) Unknown status NCT01550588 Phase 4
2 PC-Trial: Patent Foramen Ovale and Cryptogenic Embolism Unknown status NCT00166257 Phase 4
3 Patent Foramen Ovale in Cryptogenic Stroke Study Completed NCT00697151 Phase 4
4 Long-term Safety Study of the GORE® HELEX® Septal Occluder Completed NCT00581308 Phase 4
5 Atrial Fibrillation Ablation Compared to Rate Control Strategy in Patients With Impaired Left Ventricular Function Not yet recruiting NCT02509754 Phase 4
6 Evaluation of the STARFlex® Septal Closure System in Patients With a Stroke or TIA Due to the Possible Passage of a Clot of Unknown Origin Through a Patent Foramen Ovale (PFO) Unknown status NCT00201461 Phase 2, Phase 3
7 MIST II PFO-Migraine Trial With BioSTAR® Bioabsorbable Septal Repair Implant Unknown status NCT00283738 Phase 2, Phase 3
8 The Coherex FlatStent™ EF PFO Migraine Registry Unknown status NCT01280578 Phase 3
9 Patent Foramen Ovale Closure or Anticoagulants Versus Antiplatelet Therapy to Prevent Stroke Recurrence Completed NCT00562289 Phase 3
10 Concomitant Utilization of Radio Frequency Energy for Atrial Fibrillation (CURE-AF) Study Completed NCT00431834 Phase 3
11 Medtronic Concomitant Utilization of Radio Frequency for Atrial Fibrillation CURE-AF/Persistent Completed NCT00506493 Phase 3
12 GORE® HELEX® Septal Occluder / GORE® Septal Occluder for Patent Foramen Ovale (PFO) Closure in Stroke Patients - The Gore REDUCE Clinical Study Active, not recruiting NCT00738894 Phase 3
13 Cardiox Shunt Detection Technology Study Terminated NCT01333761 Phase 3
14 Right to Left Cardiac Shunt Detection Terminated NCT01773252 Phase 3
15 ESCAPE Migraine Trial Terminated NCT00267371 Phase 3
16 Premium Migraine Trial Completed NCT00355056 Phase 2
17 Safety Study of Varisolve® Procedure for Treatment of Varicose Veins in Patients With Right-to-left Cardiac Shunt Completed NCT00442364 Phase 2
18 RESPECT PFO Clinical Trial Active, not recruiting NCT00465270 Phase 2
19 Precutaneous High Risk Patent Foramen Ovale to Treat Migraine Headaches Not yet recruiting NCT02777359 Phase 2
20 PRIMA PFO Migraine Trial Terminated NCT00505570 Phase 2
21 Catheter Thrombectomy in Patients With Massive Pulmonary Embolism Terminated NCT00314002 Phase 1, Phase 2
22 Patients With Patent Foramen Ovale and Endocardial Device Leads on Apixaban for Prevention of Paradoxical Emboli Withdrawn NCT02378623 Phase 2
23 Influence of Position on Detection of Patent Foramen Ovale by Simultaneous Transesophageal Echo and Transcranial Doppler Unknown status NCT02383836
24 Prospective Clinical Follow-up After the Percutaneous Closure of a Patent Foramen Ovale Unknown status NCT01149447
25 Timing of Closure of Patent Foramen Ovale Following Birth Unknown status NCT01032785
26 InterSEPT: In‐Tunnel SeptRx European PFO Trial Unknown status NCT01385670
27 Paradigm I Clinical Trial: Study of the PFX Closure System in Subjects With Cryptogenic Stroke, Transient Ischemia Attack or Paradoxical Embolism Unknown status NCT00196027
28 International PFO Consortium Unknown status NCT00859885
29 Clinical Proteomic Research for the Brain Unknown status NCT00983723
30 Chronic Mountain Sickness, Systemic Vascular Function Unknown status NCT01182792
31 Effectiveness and Safety of Transcatheter Patent Foramen Ovale Closure for Migraine Completed NCT02127294
32 Comorbidities Associated With Migraine and Patent Foramen Ovale (CAMP) Completed NCT01257880
33 Pulmonary Embolism and Stroke in Patient With Patent Foramen Ovale Completed NCT01216423
34 Safety and Effectiveness Study of the Solysafe Septal Occluder in Patients With Atrial Septum Defect and Patent Foramen Ovale Completed NCT00207376
35 Patent Foramen Ovale and the Risk of Postoperative Delirium Following Elective Hip and Knee Arthroplasty Surgeries Completed NCT02400892
36 Procedural Success and Safety of the Nit-Occlud® Patent Foramen Ovale (PFO) Closure Device and Its Application System Completed NCT00968032
37 Risk of Stroke in Pulmonary Embolism With a Patent Foramen Ovale (PFO) Completed NCT00831259
38 Nitrogen Bubble Detection After Simulated Dives in Divers With PFO and After PFO Closure Completed NCT01854281
39 The Paradigm II Trial: PFX Closure System in Subjects With Cryptogenic Stroke, Transient Ischemic Attack, Migraine or Decompression Illness Completed NCT00196040
40 Impact Of Closure Of Patent Foramen Ovale On Apnoea-Hypopnoea-Index, Nocturnal Hypoxemia And Systemic Vascular Function In Patients With Obstructive Sleep Apnoea Completed NCT01780207
41 Patent Foramen Ovale in Children With Migraine Headaches Completed NCT00750594
42 Correlation of Right-left Shunt Detection in Cardioembolism Etiology in Stroke Patient. Completed NCT02351076
43 GORE® Septal Occluder European Union Clinical Evaluation Completed NCT01605851
44 Cardiac Troponin T After Transcatheter Closure of the Interatrial Septum Completed NCT03099967
45 Semi-automatic assessMent of Aortic Roots by Three-dimensional transoEsophageal echocaRdiography (SMARTER) Completed NCT02724709
46 Surgical Tourniquets and Cerebral Emboli Completed NCT02240732
47 Identification the Cause of Silent Cerebral infarctiON in Healthy Subjects (ICONS) Completed NCT01429948
48 Hip Fracture and Patent Foramen Ovale Recruiting NCT02564133
49 Decompression Sickness in Divers With or Without Patent Foramen Ovale Recruiting NCT02432131
50 PFO Closure for Obstructive Sleep Apnoea Recruiting NCT02771561

Search NIH Clinical Center for Patent Foramen Ovale

Cochrane evidence based reviews: foramen ovale, patent

Genetic Tests for Patent Foramen Ovale

Genetic tests related to Patent Foramen Ovale:

id Genetic test Affiliating Genes
1 Patent Foramen Ovale 29

Anatomical Context for Patent Foramen Ovale

MalaCards organs/tissues related to Patent Foramen Ovale:

Heart, Lung, Brain, Liver, Spinal Cord, Testes, Endothelial

Publications for Patent Foramen Ovale

Articles related to Patent Foramen Ovale:

(show top 50) (show all 709)
id Title Authors Year
Patent Foramen Ovale and Cryptogenic Strokes in the Stroke in Young Fabry Patients Study. ( 27899752 )
To close or not to close: contemporary indications for patent foramen ovale closure. ( 27616622 )
Patent foramen ovale and stroke in childhood: A systematic review of the literature. ( 27169856 )
Case report: Renal infarction by paradoxical embolism through the patent foramen ovale as an unusual cause of post-operative abdominal pain after sleeve gastrectomy. ( 27449763 )
Resting arterial hypoxaemia in subjects with chronic heart failure, pulmonary hypertension and patent foramen ovale. ( 26990684 )
A benign patent foramen ovale in off-pump coronary artery bypass can suddenly take a right turn, but can it be tolerated? ( 27113620 )
Patent foramen ovale: a novel cardiovascular risk factor in patients with sleep disordered breathing and high altitude dwellers? ( 27878796 )
Stepwise Progression of Right-to-Left Atrial Shunting through a Combination of Patent Foramen Ovale and Tricuspid Regurgitation. ( 27127438 )
Unresolved or Contradictory Issues About Management of Patients With Patent Foramen Ovale and Previous Cryptogenic Stroke: Additional Randomized Controlled Trials Are Eagerly Awaited. ( 27081420 )
Recent development of transcatheter closure of atrial septal defect and patent foramen ovale with occluders. ( 28024095 )
Response: Commentary: Correlation between Patent Foramen Ovale, Cerebral "Lesions" and Neuropsychometric Testing in Experienced Sports Divers: Does Diving Damage the Brain? ( 27822190 )
Surgical Treatment for Thrombus Straddling a Patent Foramen Ovale. ( 27982351 )
Thromboembolism-in-Transit and Patent Foramen Ovale: Should Screening Echocardiogram Be Routine for Thromboembolic Disease? ( 27660585 )
Recurrent Stroke due to Patent Foramen Ovale Closure Device Thrombus Eight Years after Implantation. ( 27444520 )
Recurrent Fat Embolic Strokes in a Patient With Duchenne Muscular Dystrophy With Long Bone Fractures and a Patent Foramen Ovale. ( 27595520 )
Amplatzer versus Figulla occluder for transcatheter patent foramen ovale closure. ( 27993750 )
Commentary: Correlation between Patent Foramen Ovale, Cerebral "Lesions" and Neuropsychometric Testing in Experienced Sports Divers: Does Diving Damage the Brain? ( 27604662 )
Three-dimensional Echocardiography for Percutaneous Occlusion of Patent Foramen Ovale. ( 27027371 )
Effect of patent ductus arteriosus and patent foramen ovale on left ventricular stroke volume measurement by electrical velocimetry in comparison to transthoracic echocardiography in neonates. ( 27072988 )
Percutaneous closure of patent foramen ovale in migraine with aura, a randomized controlled trial. ( 26908949 )
A very rare association between giant right atrial myxoma and patent foramen ovale. Extracellular matrix and morphological aspects: a case report. ( 27516037 )
Clinically apparent long-term electric disturbances in the acute and very long-term of patent foramen ovale device-based closure. ( 27847261 )
Patent Foramen Ovale and Migraine: Casual or Causal. ( 27114976 )
The relationship of patent foramen ovale location with severity of stroke: A new risk factor for paradoxical embolism. ( 27075798 )
Echocardiographic Follow-Up of Patent Foramen Ovale and the Factors Affecting Spontaneous Closure. ( 27899861 )
Patent Foramen Ovale With Atrial Septal Aneurysm Is Strongly Associated With Migraine With Aura: A Large Observational Study. ( 27930349 )
close: Closure of patent foramen ovale, oral anticoagulants or antiplatelet therapy to prevent stroke recurrence: Study design. ( 27056964 )
Patent foramen ovale in idiopathic pulmonary arterial hypertension: Long-term risk and morbidity. ( 27578471 )
Stent placement for palliation of cor triatriatum dexter in a dog with suspected patent foramen ovale. ( 26777393 )
Intracardiac thrombus trapped in a patent foramen ovale. ( 27173872 )
Multidisciplinary Assessment in Optimising Results of Percutaneous Patent Foramen Ovale Closure. ( 27555053 )
Extensive biatrial thrombus straddling the patent foramen ovale and traversing into the left and right ventricle. ( 27873765 )
Percutaneous left atrial appendage closure through a patent foramen ovale evaluated by intraprocedural transesophageal echocardiography. ( 27178699 )
Effectiveness and Safety of Transcatheter Patent Foramen Ovale Closure for Migraine (EASTFORM) Trial. ( 27966652 )
Economy Class Syndrome, Patent Foramen Ovale and Stroke. ( 27567137 )
Inferior Vena Cava Compression as a Novel Maneuver to Detect Patent Foramen Ovale: AA Transesophageal Echocardiographic Study. ( 28024853 )
No Relationship Between Patent Foramen Ovale and Migraine Frequency. ( 27634435 )
Unexpected perforation leading to life-threatening cardiac tamponade six years after patent foramen ovale closure with an intrasept device. ( 27090049 )
Leonardo da Vinci and patent foramen ovale: An historical perspective. ( 27522382 )
Practice advisory: Recurrent stroke with patent foramen ovale (update of practice parameter): Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. ( 27466464 )
The role of coronary CT angiography in diagnosis of patent foramen ovale. ( 27152642 )
Paradoxical Embolus Stuck in a Patent Foramen Ovale. ( 28018828 )
Transient Ischemic Attack After Foam Sclerotherapy in a Woman With a Patent Foramen Ovale. ( 27111786 )
TCT-826 Prospective single center First In Human (FIH) clinical trial to evaluate the safety and effectiveness of a septal occluder with bioresorbable framework in patients with clinically significant atrial septum defect (ASD) or patent foramen ovale (PFO). ( 27970217 )
Bilateral thalamic stroke due to occlusion of the artery of Percheron in a patient with a patent foramen ovale. ( 27003984 )
Anaesthetic Management of Laparoscopic Morgagni Hernia Repair in a Patient with Coexisting Down Syndrome, Patent Foramen Ovale and Pectus Carinatum. ( 27366555 )
Sleep apnea syndrome and patent foramen ovale: a dangerous association in ischemic stroke? ( 27823712 )
Thrombotic mass traversing a patent foramen ovale. ( 27507573 )
Patent foramen ovale: indications for closure and techniques. ( 27174117 )
Patent Foramen Ovale Combined With Pulmonary Arteriovenous Malformation. ( 27765314 )

Variations for Patent Foramen Ovale

ClinVar genetic disease variations for Patent Foramen Ovale:

id Gene Variation Type Significance SNP ID Assembly Location
1 Translocation Likely pathogenic
2 46;XX;inv(7)(q21.2q34) Translocation Likely pathogenic

Expression for Patent Foramen Ovale

Search GEO for disease gene expression data for Patent Foramen Ovale.

Pathways for Patent Foramen Ovale

GO Terms for Patent Foramen Ovale

Cellular components related to Patent Foramen Ovale according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.56 F2 F5 FGA SERPINC1
2 platelet alpha granule GO:0031091 9.16 F5 FGA
3 platelet alpha granule lumen GO:0031093 9.13 F13A1 F5 FGA
4 blood microparticle GO:0072562 9.02 ACTC1 F13A1 F2 FGA SERPINC1

Biological processes related to Patent Foramen Ovale according to GeneCards Suite gene sharing:

(show all 39)
id Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.96 CITED2 EDNRA NKX2-5 TBX5
2 cellular protein metabolic process GO:0044267 9.92 F2 F5 FGA GATA6 SERPINC1
3 platelet degranulation GO:0002576 9.86 APOH F13A1 F5 FGA
4 negative regulation of cell migration GO:0030336 9.85 CITED2 NKX2-1 TBX5
5 heart looping GO:0001947 9.81 GATA4 NKX2-5 TBX20
6 outflow tract morphogenesis GO:0003151 9.79 CITED2 NKX2-5 TBX20
7 cardiac muscle contraction GO:0060048 9.77 ACTC1 MYH6 NKX2-5
8 blood circulation GO:0008015 9.76 F5 MTHFR TBX20
9 outflow tract septum morphogenesis GO:0003148 9.71 GATA6 NKX2-5 TBX20
10 positive regulation of cardiac muscle cell proliferation GO:0060045 9.69 GATA6 TBX20 TBX5
11 heart contraction GO:0060047 9.67 ACTC1 NKX2-5
12 cardiac muscle hypertrophy in response to stress GO:0014898 9.67 GATA6 MYH6
13 fibrinolysis GO:0042730 9.67 F12 F2 FGA
14 cardiac muscle cell differentiation GO:0055007 9.67 GATA4 GATA6 NKX2-5 TBX5
15 cardiac right ventricle morphogenesis GO:0003215 9.66 GATA4 TBX20
16 adult heart development GO:0007512 9.66 MYH6 NKX2-5
17 endocardial cushion development GO:0003197 9.65 GATA4 TBX5
18 plasminogen activation GO:0031639 9.65 APOH FGA
19 blood coagulation, intrinsic pathway GO:0007597 9.65 APOH F12 F2
20 cardiac ventricle morphogenesis GO:0003208 9.64 GATA4 NKX2-5
21 negative regulation of fibrinolysis GO:0051918 9.64 APOH F2
22 intestinal epithelial cell differentiation GO:0060575 9.63 GATA4 GATA6
23 lung saccule development GO:0060430 9.62 GATA6 NKX2-1
24 regulation of blood coagulation GO:0030193 9.62 APOH F12 F2 SERPINC1
25 Type II pneumocyte differentiation GO:0060510 9.61 GATA6 NKX2-1
26 positive regulation of blood coagulation GO:0030194 9.61 APOH F12 F2
27 blood coagulation, fibrin clot formation GO:0072378 9.6 F13A1 FGA
28 Clara cell differentiation GO:0060486 9.58 GATA6 NKX2-1
29 cardiac muscle tissue morphogenesis GO:0055008 9.58 ACTC1 NKX2-5 TBX20
30 embryonic heart tube left/right pattern formation GO:0060971 9.57 CITED2 NKX2-5
31 atrial septum morphogenesis GO:0060413 9.56 GATA4 NKX2-5 TBX20 TBX5
32 bundle of His development GO:0003166 9.55 NKX2-5 TBX5
33 positive regulation of cardioblast differentiation GO:0051891 9.46 GATA4 GATA6 NKX2-5 TBX5
34 hemostasis GO:0007599 9.43 F12 F13A1 F2 F5 FGA SERPINC1
35 blood coagulation GO:0007596 9.23 F12 F13A1 F2 F5 FGA GATA4
36 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10.17 CITED2 GATA4 GATA6 NKX2-1 NKX2-5 TBX20
37 transcription from RNA polymerase II promoter GO:0006366 10.08 CITED2 GATA4 GATA6 NKX2-5 TBX20
38 negative regulation of transcription, DNA-templated GO:0045892 10.06 CITED2 GATA6 NKX2-1 NKX2-5 TBX20
39 positive regulation of transcription, DNA-templated GO:0045893 10 CITED2 GATA4 GATA6 NKX2-1 NKX2-5 TBX20

Molecular functions related to Patent Foramen Ovale according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor activity, sequence-specific DNA binding GO:0003700 9.8 CITED2 GATA4 GATA6 NKX2-1 NKX2-5 TBX20
2 serine-type endopeptidase activity GO:0004252 9.71 F12 F2 F5 TLL1
3 transcription regulatory region DNA binding GO:0044212 9.67 GATA4 GATA6 NKX2-1 NKX2-5
4 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003705 9.5 GATA6 NKX2-1 NKX2-5
5 RNA polymerase II transcription factor binding GO:0001085 9.33 GATA4 GATA6 TBX20
6 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0001228 9.26 GATA4 GATA6 NKX2-5 TBX5
7 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.02 GATA4 GATA6 NKX2-1 TBX20 TBX5

Sources for Patent Foramen Ovale

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
52 Novoseek
55 OMIM via Orphanet
59 PubMed
65 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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