MCID: PTN001
MIFTS: 60

Patent Foramen Ovale malady

Cardiovascular diseases, Fetal diseases, Endocrine diseases categories

Summaries for Patent Foramen Ovale

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63Wikipedia, 32MalaCards
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Wikipedia:63 Atrial septal defect (ASD) is a form of a congenital heart defect that enables blood flow between two... more...

MalaCards: Patent Foramen Ovale, also known as atrial septal defect within oval fossa, is related to migraine and stroke, ischemic. An important gene associated with Patent Foramen Ovale is NKX2-5 (NK2 homeobox 5), and among its related pathways are Platelet activation, signaling and aggregation and Platelet degranulation . The compounds coumarins and warfarin have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and thyroid, and related mouse phenotypes are reproductive system and cardiovascular system.

Aliases & Classifications for Patent Foramen Ovale

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Cardiovascular diseases, Endocrine diseases


Aliases & Descriptions:

patent foramen ovale 8 10 48
atrial septal defect within oval fossa 8 60
foramen ovale patent 8 44
thyroid hormone plasma membrane transport defect 60
ostium secundum type atrial septal defect 8
atrial septal defect ostium secundum 42
persistent, ostium secundum 8
persistent ostium secundum 8
asd ostium secundum type 42
foramen ovale, patent 60
ostium secundum asd 42
defect, patent 8


External Ids:

Disease Ontology8 DOID:13620
NCIt39 C34619
MeSH34 D054092
MESH via Orphanet35 D054092
ICD10 via Orphanet26 Q21.1
SNOMED-CT via Orphanet57 204317008
UMLS via Orphanet61 C0016522

Related Diseases for Patent Foramen Ovale

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17GeneCards, 18GeneDecks
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Diseases related to Patent Foramen Ovale via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 222)
idRelated DiseaseScoreTop Affiliating Genes
1migraine31.6APOH, EDNRA, MTHFR, CLNK, GOLPH3
2stroke, ischemic31.4F5, F2
3pulmonary embolism31.3APOH, F5, MTHFR, F13A1, FGA, F2
4myocardial infarction31.0F5, MTHFR, F13A1, FGA, PLAT, SERPINC1
5hypertension30.9EDNRA, F5, MTHFR, F2, PLAT
6retinal artery occlusion30.9APOH
7ischemia30.7EDNRA, FGA, NMT1, PLAT
8thrombophilia30.7F13A1, F12, FGA, F2, PLAT, SERPINC1
9central retinal artery occlusion30.6PLAT
10acute myocardial infarction30.6FGA, PLAT, SERPINC1
11antiphospholipid syndrome30.6APOH, F5, MTHFR, F2, PLAT, SERPINC1
12atherosclerosis30.6EDNRA, MTHFR, F13A1, FGA, PLAT, SERPINC1
13congenital heart defect30.5EDNRA, MTHFR, F12, NKX2-5, F2
14branch retinal artery occlusion30.4F5
15sickle cell disease30.4FGA
16primary pulmonary hypertension30.4FGA
17obesity30.4EDNRA
18respiratory failure30.4SERPINC1, NKX2-1
19cerebrovascular disease30.4F12, F13A1, MTHFR, APOH
20protein c deficiency30.4APOH, F5, MTHFR, F2, SERPINC1
21protein s deficiency30.3APOH, F5, MTHFR, FGA, F2, SERPINC1
22hyperhomocysteinemia30.3APOH, F5, MTHFR, F2, PLAT, SERPINC1
23cerebritis10.9
24migraine with aura10.8
25retinitis10.6
26thyroid hormone plasma membrane transport defect10.6
27endocarditis10.6
28atrial septal defect 810.5
29arteriovenous fistula10.4
30acute cor pulmonale10.4
31mitral valve prolapse10.4
32migraine without aura10.4
33noonan syndrome10.4
34aortic atherosclerosis10.4
35aortic aneurysm10.4
36glanzmann's thrombasthenia10.4
37takayasu's arteritis10.4
38atrioventricular septal defect10.4
39congenital diaphragmatic hernia10.4
40atrial heart septal defect10.4
41urea cycle disorder10.4
42hereditary folate malabsorption10.4
43zap70-related severe combined immunodeficiency10.4
44acro-pectoro-renal field defect10.4
45ankle defects short stature10.4
46axial mesodermal dysplasia spectrum10.4
47branchial arch defects10.4
48cardioskeletal syndrome kuwaiti type10.4
49sacral defect with anterior meningocele10.4
50caudal regression syndrome10.4

Graphical network of the top 20 diseases related to Patent Foramen Ovale:



Diseases related to patent foramen ovale

Clinical Features for Patent Foramen Ovale

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Drugs & Therapeutics for Patent Foramen Ovale

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Patent Foramen Ovale

Genetic Tests for Patent Foramen Ovale

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Anatomical Context for Patent Foramen Ovale

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32MalaCards
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MalaCards organs/tissues related to Patent Foramen Ovale:

32
Brain, Heart, Thyroid, Spinal cord, Liver, Lung, Testes, Endothelial

Animal Models for Patent Foramen Ovale or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Patent Foramen Ovale:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053899.3MTHFR, POLL, FGA, SERPINC1
2MP:00053858.4EDNRA, F13A1, NKX2-5, NKX2-1, TBX20, FGA
3MP:00053888.4PLAT, F2, NKX2-1, NKX2-5, F13A1, EDNRA
4MP:00053808.4EDNRA, F5, NKX2-5, TBX20, FGA, F2
5MP:00053977.7EDNRA, F13A1, NKX2-5, POLL, FGA, CLNK
6MP:00036317.4EDNRA, F5, MTHFR, F12, NKX2-1, FGA
7MP:00053766.4SERPINC1, APOH, EDNRA, F5, MTHFR, F13A1
8MP:00107686.3F13A1, MTHFR, F5, EDNRA, APOH, NKX2-5

Publications for Patent Foramen Ovale

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50PubMed
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Articles related to Patent Foramen Ovale:

(show top 50)    (show all 582)
idTitleAuthorsYear
1
Amplatzer left atrial appendage occlusion through a patent foramen ovale. (24399612)
2014
2
Cardiac procedures to prevent stroke: patent foramen ovale closure/left atrial appendage occlusion. (24365193)
2014
3
Thrombus formation in a patent foramen ovale. (23528287)
2013
4
Neurosurgery in the Semisitting Position in Patients with a Patent Foramen Ovale. (23920299)
2013
5
Patent foramen ovale screening by ear oximetry in divers. (23102475)
2013
6
Understanding the role of patent foramen ovale in stroke. (23507950)
2013
7
Response to letter regarding article, a89critique of closure or medical therapy for cryptogenic stroke with patent foramen ovale: the hole truth?a89. (23451348)
2013
8
Prevalence of patent foramen ovale and its impact on oxygen desaturation in obstructive sleep apnea. (21816494)
2013
9
Initial use of the new GORE(Ar) septal occluder in patent foramen ovale closure: implantation and preliminary results. (23436483)
2013
10
Cardioembolic stroke in patients with patent foramen ovale and implanted cardiac leads. (23077982)
2013
11
Inadvertent left ventricular pacing through a patent foramen ovale: identification, management and implications for postpacemaker implantation checks. (23814191)
2013
12
A novel technique to remove a right atrial thrombotic mass attached to a patent foramen ovale (PFO) closure device. (23613302)
2013
13
Successful percutaneous transcatheter patent foramen ovale closure through the right internal jugular vein using a steerable catheter. (23413211)
2013
14
The sitting position and the patent foramen ovale. Commentary: "A streamlined protocol for the use of the semi-sitting position in neurosurgery". (23103318)
2013
15
A new method for patent foramen ovale closure: delivering sheath over coronary sinus catheter into left atrium. (23508551)
2013
16
Transcranial Doppler quantification of residual shunt after percutaneous patent foramen ovale closure: correlation of device efficacy with intracardiac anatomic measures. (22364421)
2012
17
Diagnosis and management of patent foramen ovale. (22282739)
2012
18
Long-term results of the amplatzer cribriform occluder for patent foramen ovale with associated atrial septal aneurysm: impact on occlusion rate and left atrial functional remodelling. (22254216)
2012
19
Detection of patent foramen ovale by 3D echocardiography. (22421180)
2012
20
Long-term propensity score-matched comparison of percutaneous closure of patent foramen ovale with medical treatment after paradoxical embolism. (22238228)
2012
21
Device closure for stroke with patent foramen ovale. (22694009)
2012
22
Hypoplastic left heart syndrome, restrictive patent foramen ovale, and pulmonary valve stenosis: an unusual combination. (21984265)
2012
23
Device closure for stroke with patent foramen ovale. (22694008)
2012
24
G1691A factor V and G20210A FII mutations, acute ischemic stroke of unknown cause, and patent foramen ovale. (22909823)
2012
25
Minimally invasive retrieval of patent foramen ovale closure device after device migration to the descending aorta. (22949785)
2012
26
Evaluation of patent foramen ovale in young adults with cryptogenic stroke. (22577450)
2011
27
Risk and fate of residual interatrial shunting after transcatheter closure of patent foramen ovale: a long term follow up study. (21345765)
2011
28
Enhanced detection of patent foramen ovale by systematic transthoracic saline contrast echocardiography. (20619473)
2011
29
A rare complication of thromboembolism: entrapped thrombus in a patent foramen ovale. (21743272)
2011
30
Transcatheter closure of patent foramen ovale in Chinese patients with paradoxical embolism. -Immediate results and long-term follow-up-. (21617325)
2011
31
Acute mitral regurgitation after acute myocardial infarction in a patient with a patent foramen ovale: review of the diagnosis and management of acute ischemic mitral regurgitation. (20224319)
2011
32
Contrast transthoracic echocardiography versus transcranial Doppler for patent foramen ovale detection. (21640404)
2011
33
A suspected case of paradoxical renal embolism through the patent foramen ovale. (20960022)
2011
34
Patent foramen ovale-mania: an unusual case of misdiagnosis. (22134472)
2011
35
Does patent foramen ovale closure have an anti-arrhythmic effect? A meta-analysis. (21420189)
2011
36
Effect of a patent foramen ovale on pulmonary gas exchange efficiency at rest and during exercise. (21372097)
2011
37
Atypical presentation of basilar artery thrombosis due to hypercoagulable state and incidental patent foramen ovale: a case report. (20939207)
2010
38
Straddling patent foramen ovale thrombus associated with pulmonary embolism managed with thrombolysis. (21280485)
2010
39
Massive pulmonary embolism and acute limb ischaemia in a patient of hereditary spherocytosis and patent foramen ovale. (20619736)
2010
40
Patent foramen ovale: a comprehensive review for pulmonologists. (20592599)
2010
41
Diagnosis and therapy for pulmonary arteriovenous fistula in patients with presumed patent foramen ovale. (20066724)
2010
42
Patent foramen ovale, bubble test, and major spine surgery. (20613469)
2010
43
E-page original images. Impending thrombus through a patent foramen ovale complicated by pulmonary embolism: successful treatment with thrombolytic application. (21062689)
2010
44
Patent foramen ovale is not associated with an increased risk of stroke recurrence. (20412294)
2010
45
Is patent foramen ovale closure indicated for migraine?: patent foramen ovale closure for migraine. (20031758)
2009
46
Central retinal artery occlusion associated with a patent foramen ovale. (17290211)
2007
47
That balloon atrial septostomy is associated with preoperative stroke in neonates with transposition of the great arteries is another powerful argument in favor of therapeutic closure of every patent foramen ovale. (16828611)
2006
48
Factor V Leiden and prothrombin gene mutation may predispose to paradoxical embolism in subjects with patent foramen ovale. (12695749)
2003
49
Catheter closure of atrial septal defects and patent foramen ovale in patients with an atrial septal aneurysm using different devices. (12053327)
2001
50
Status of patent foramen ovale, atrial septal aneurysm, atrial septal defect and aortic arch atheroma as risk factors for stroke. (9346341)
1997

Genetic Variations for Patent Foramen Ovale

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Expression for genes affiliated with Patent Foramen Ovale

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Patent Foramen Ovale

Search GEO for disease gene expression data for Patent Foramen Ovale.

Pathways for genes affiliated with Patent Foramen Ovale

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Sources:
53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN, 52R&D Systems, 29KEGG
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Compounds for genes affiliated with Patent Foramen Ovale

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 2BitterDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Patent Foramen Ovale according to GeneCards/GeneDecks:

(show top 50)    (show all 99)
idCompoundScoreTop Affiliating Genes
1coumarins4410.5APOH
2warfarin44 49 11 2413.1APOH, FGA, SERPINC1
3inogatran4410.0SERPINC1, F2, F5
4ecarin4410.0F5, F2, SERPINC1
5nafamostat mesilate4410.0SERPINC1, FGA, F5
6danaparoid449.9F5, SERPINC1, F2
7ximelagatran44 1110.9F5, SERPINC1, F2
8kaolin449.9APOH, F2, F12, F5
911-dehydrothromboxane b2449.9F2, APOH, FGA
10desogestrel44 1110.9F2, F5, SERPINC1
11gestodene44 1110.8F5, F2, SERPINC1
12hirugen449.8FGA, F5, F2, SERPINC1
13heparinoids449.7F5, F13A1, F2, SERPINC1
14coumarin44 2 49 2412.7F5, SERPINC1, F2, FGA
15gabexate mesilate449.7F5, SERPINC1, PLAT
16batroxobin449.7PLAT, FGA, F5, F2
17tranexamic acid44 1110.6PLAT, F2, SERPINC1
18spectrozyme449.6SERPINC1, F5, F2, PLAT
19serine449.6F12, NKX2-5, NKX2-1, FGA
20fondaparinux449.6F5, PLAT, SERPINC1, F2
21ptca449.6APOH, FGA, PLAT
22protamine sulfate449.6PLAT, F2, F5, SERPINC1
23fibrinopeptide a449.6PLAT, SERPINC1, FGA, F2
24tirofiban44 1110.6SERPINC1, PLAT, F2
25ristocetin449.6F5, F2, PLAT, SERPINC1
26aprotinin44 1110.6F5, PLAT, SERPINC1, FGA
27ticlopidine44 1110.6APOH, FGA, PLAT, SERPINC1
28ppack449.5SERPINC1, PLAT, F2, FGA
29levonorgestrel44 59 28 1112.5F5, PLAT, SERPINC1, F2
30epsilon aminocaproic acid449.5SERPINC1, PLAT, F2
31desmopressin44 59 28 1112.5F5, SERPINC1, PLAT, F2
32heparin44 28 11 2412.5F12, APOH, MTHFR, F13A1, FGA
33dermatan sulfate449.5F5, F2, PLAT, SERPINC1
34pge1449.4FGA, F2, APOH, PLAT, F5
35ancrod449.4F5, F2, SERPINC1, PLAT, FGA
36bivalirudin44 1110.4SERPINC1, PLAT, FGA, F5, F2
37argatroban44 1110.4SERPINC1, F2, FGA, F5, PLAT
38hirudin449.3SERPINC1, PLAT, F2, FGA, F5
39protamine449.3SERPINC1, PLAT, FGA, F5, F2
40diltiazem44 28 1111.3SERPINC1, PLAT, F2
41p002449.2PLAT, MTHFR, F5, APOH
42abciximab44 1110.1F2, SERPINC1, PLAT
43prostacyclin449.0PLAT, APOH, FGA, F5, EDNRA, SERPINC1
44homocysteine44 2410.0PLAT, F2, F5, MTHFR, SERPINC1, APOH
45kininogen448.8SERPINC1, APOH, F5, F12, F2, PLAT
46cholesterol44 28 11 2411.6MTHFR, F5, APOH, FGA, PLAT, EDNRA
47creatinine448.4F5, MTHFR, APOH, EDNRA, FGA, F2
48aspirin44 49 28 2411.2PLAT, F2, FGA, F12, F13A1, MTHFR
49fibrinogen448.2FGA, PLAT, F2, F12, SERPINC1, APOH
50estrogen448.0SERPINC1, F2, NKX2-1, F12, F13A1, MTHFR

GO Terms for genes affiliated with Patent Foramen Ovale

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16Gene Ontology
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Cellular components related to Patent Foramen Ovale according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.3F5, F13A1, FGA
2extracellular spaceGO:0056158.4SERPINC1, PLAT, F2, FGA, F12, F5
3extracellular regionGO:0055768.4SERPINC1, PLAT, F2, FGA, F12, F13A1

Biological processes related to Patent Foramen Ovale according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1atrial septum morphogenesisGO:06041310.2NKX2-5, TBX20
2cardiac muscle tissue morphogenesisGO:05500810.1TBX20, NKX2-5
3negative regulation of fibrinolysisGO:05191810.0APOH, F2
4positive regulation of blood coagulationGO:03019410.0F2, F12, APOH
5blood coagulation, intrinsic pathwayGO:00759710.0APOH, F12, F2
6plasminogen activationGO:03163910.0APOH, PLAT
7outflow tract septum morphogenesisGO:00314810.0TBX20, NKX2-5
8blood circulationGO:0080159.9TBX20, MTHFR, F5
9fibrinolysisGO:0427309.8F12, F2, PLAT
10platelet degranulationGO:0025769.7FGA, F13A1, F5
11negative regulation of proteolysisGO:0458619.7PLAT, F2
12positive regulation of release of sequestered calcium ion into cytosolGO:0512819.6F2, EDNRA
13platelet activationGO:0301689.5F2, FGA, F13A1, F5
14blood coagulationGO:0075968.6SERPINC1, F5, F13A1, F12, FGA, F2

Molecular functions related to Patent Foramen Ovale according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.4GOLPH3, EDNRA, F5, F12, NKX2-5, NKX2-1

Products for genes affiliated with Patent Foramen Ovale

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  • Antibodies
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Sources for Patent Foramen Ovale

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet