MCID: PTN001
MIFTS: 58

Patent Foramen Ovale

Categories: Rare diseases, Cardiovascular diseases, Fetal diseases

Aliases & Classifications for Patent Foramen Ovale

MalaCards integrated aliases for Patent Foramen Ovale:

Name: Patent Foramen Ovale 12 55 28 14
Foramen Ovale, Patent 41 69
Foramen Ovale Patent 12 51
Defect, Patent or Persistent, Ostium Secundum 12
Atrial Septal Defect, Ostium Secundum Type 55
Ostium Secundum Type Atrial Septal Defect 12
Atrial Septal Defect Within Oval Fossa 12
Ostium Secundum Atrial Septal Defect 49
Persistent Ostium Secundum 12
Asd, Ostium Secundum Type 55
Asd Ostium Secundum Type 49
Ostium Secundum Asd 49
Osasd 49

Classifications:



External Ids:

Disease Ontology 12 DOID:13620
ICD10 32 Q21.1
MeSH 41 D054092
NCIt 46 C34619
MESH via Orphanet 42 D054092
UMLS via Orphanet 70 C0016522 C0344724
ICD10 via Orphanet 33 Q21.1
UMLS 69 C0016522

Summaries for Patent Foramen Ovale

NIH Rare Diseases : 49 An ostium secundum atrial septal defect is a type of congenital heart defect called an atrial septal defect (ASD). An ASD is a hole in the wall (septum) between the two upper chambers of the heart (the atria). ASDs can be classified by location. An ostium secundum ASD is a hole in the center of the atrial septum. Normally, the right side of the heart pumps oxygen-poor blood to the lungs, while the left side pumps oxygen-rich blood to the body. An ASD allows blood from both sides to mix, causing the heart to work less efficiently. A small hole may not cause any symptoms or problems. A larger hole can eventually cause symptoms such as shortness of breath, respiratory infections, fainting, irregular heart rhythms or fatigue after mild activity. Larger ASDs can also ultimately lead to pulmonary artery hypertension, right ventricular hypertrophy (enlargement); SVT, or heart failure. Most cases of ASD are not inherited and occur by chance. Some cases appear to have autosomal dominant inheritance. Treatment may not be needed for small ASDs, which often close on their own. Larger ASDs are typically closed during childhood with open heart surgery or by cardiac catheterization. Last updated: 8/4/2016

MalaCards based summary : Patent Foramen Ovale, also known as foramen ovale, patent, is related to pulmonary embolism and thrombosis. An important gene associated with Patent Foramen Ovale is NKX2-5 (NK2 Homeobox 5), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Aspirin and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Patent Foramen Ovale

Diseases related to Patent Foramen Ovale via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 218)
# Related Disease Score Top Affiliating Genes
1 pulmonary embolism 31.5 APOH F2 F5 MTHFR SERPINC1
2 thrombosis 31.2 APOH F2 F5 MTHFR SERPINC1
3 endocarditis 31.2 APOH F2 SERPINC1
4 retinal artery occlusion 31.0 APOH F2 F5 MTHFR SERPINC1
5 amaurosis fugax 30.8 F5 MTHFR
6 branch retinal artery occlusion 30.8 APOH F2 MTHFR SERPINC1
7 transposition of the great arteries 30.8 GATA4 GATA6 MED13L NKX2-5
8 myocardial infarction 30.8 F2 F5 FGA GATA4 MTHFR SERPINC1
9 sticky platelet syndrome 30.7 F5 SERPINC1
10 spinal cord infarction 30.7 APOH F2 F5 MTHFR SERPINC1
11 thrombophilia due to thrombin defect 30.7 APOH F2 F5 MTHFR SERPINC1
12 antiphospholipid syndrome 30.7 APOH F2 F5 MTHFR SERPINC1
13 thrombophilia 30.6 APOH F2 F5 FGA MTHFR SERPINC1
14 cerebrovascular disease 30.6 F12 F2 F5 MTHFR
15 atrial heart septal defect 30.6 ACTC1 F2 GATA4 MYH6 NKX2-5 TBX20
16 stroke, ischemic 30.5 APOH F2 F5 FGA MTHFR SERPINC1
17 budd-chiari syndrome 30.4 APOH F2 F5 MTHFR SERPINC1
18 pulmonary valve stenosis 30.0 GATA4 TBX5
19 heart disease 28.9 ACTC1 CITED2 EDNRA F2 GATA4 MTHFR
20 hypoplastic left heart syndrome 11.6
21 mental retardation and distinctive facial features with or without cardiac defects 11.4
22 right pulmonary artery, anomalous origin of, familial 11.4
23 tricuspid atresia 11.2
24 short stature, developmental delay, and congenital heart defects 11.2
25 right ventricle hypoplasia 11.2
26 migraine with or without aura 1 10.8
27 aneurysm 10.8
28 atrial septal aneurysm 10.8
29 may-thurner syndrome 10.7 APOH F5
30 paracetamol poisoning 10.7 F2 F5
31 inferior vena cava interruption 10.7 F5 MTHFR
32 acanthamoeba keratitis 10.6 APOH F5
33 cerebritis 10.6
34 cerebral sinovenous thrombosis 10.6 APOH F2 F5
35 cryptogenic cirrhosis 10.6 F2 F5 MTHFR
36 porencephaly 10.6 F2 F5 MTHFR
37 pregnancy loss, recurrent 1 10.6 APOH F5 MTHFR
38 arteritic anterior ischemic optic neuropathy 10.6 F2 F5 MTHFR
39 mesenteric vascular occlusion 10.6 F2 MTHFR
40 catastrophic antiphospholipid syndrome 10.6 APOH F5 MTHFR
41 thrombasthenia 10.6 F2 F5 MTHFR
42 sagittal sinus thrombosis 10.6 F2 F5 SERPINC1
43 buerger disease 10.6 APOH F2 MTHFR
44 headache 10.6
45 post-thrombotic syndrome 10.6 F2 F5 SERPINC1
46 blood protein disease 10.6 F2 MTHFR SERPINC1
47 intracranial embolism 10.5 F12 F2 SERPINC1
48 marantic endocarditis 10.5 F2 MTHFR SERPINC1
49 intestinal impaction 10.5 F2 SERPINC1
50 factor x deficiency 10.5 F2 F5 SERPINC1

Graphical network of the top 20 diseases related to Patent Foramen Ovale:



Diseases related to Patent Foramen Ovale

Symptoms & Phenotypes for Patent Foramen Ovale

MGI Mouse Phenotypes related to Patent Foramen Ovale:

43 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.44 FGA ACTC1 F2 CITED2 F5 EDNRA
2 homeostasis/metabolism MP:0005376 10.43 FGA ACTC1 F12 APOH F2 CITED2
3 mortality/aging MP:0010768 10.36 ACTC1 APOH F2 CITED2 F5 EDNRA
4 growth/size/body region MP:0005378 10.34 ACTC1 F2 CITED2 F5 EDNRA GATA6
5 embryo MP:0005380 10.25 F2 CITED2 F5 EDNRA GATA6 FGA
6 digestive/alimentary MP:0005381 10.13 EDNRA F2 CITED2 FGA GATA4 NKX2-1
7 nervous system MP:0003631 10.1 EDNRA F12 F2 CITED2 F5 FGA
8 integument MP:0010771 10.06 F5 EDNRA F2 FGA MTHFR GATA4
9 liver/biliary system MP:0005370 10.03 F5 GATA6 FGA MYH6 GATA4 TKT
10 muscle MP:0005369 10.02 ACTC1 EDNRA GATA6 MYH6 GATA4 TBX5
11 normal MP:0002873 10 F12 ACTC1 F2 CITED2 EDNRA GATA6
12 reproductive system MP:0005389 9.81 F12 F2 NKX2-1 GATA6 FGA MTHFR
13 respiratory system MP:0005388 9.56 EDNRA F2 CITED2 GATA6 MYH6 GATA4
14 skeleton MP:0005390 9.28 EDNRA F2 CITED2 NKX2-1 FGA MTHFR

Drugs & Therapeutics for Patent Foramen Ovale

Drugs for Patent Foramen Ovale (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-78-2 2244
2
Clopidogrel Approved Phase 4,Phase 3,Phase 2 120202-66-6, 113665-84-2 60606
3
Warfarin Approved Phase 4,Phase 2,Phase 3 81-81-2 54678486 6691
4 Analgesics Phase 4,Phase 2,Phase 3
5 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3
6 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
7 Antipyretics Phase 4,Phase 2,Phase 3
8 Fibrinolytic Agents Phase 4,Phase 3,Phase 2
9 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2
10 Anticoagulants Phase 4,Phase 3,Phase 2
11 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2
12 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
13 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2
14 Antirheumatic Agents Phase 4,Phase 3,Phase 2
15 Coagulants Phase 4
16
Acetaminophen Approved Phase 2, Phase 3 103-90-2 1983
17
Dipyridamole Approved Phase 3,Phase 2 58-32-2 3108
18
Rivaroxaban Approved Phase 3 366789-02-8
19
Apixaban Approved Phase 3,Phase 2 503612-47-3 10182969
20 Dabigatran Phase 3
21
protease inhibitors Phase 3,Phase 2
22 Serine Proteinase Inhibitors Phase 3,Phase 2
23 HIV Protease Inhibitors Phase 3,Phase 2
24 Pharmaceutical Solutions Phase 3,Phase 2
25 Factor Xa Inhibitors Phase 3,Phase 2
26 Antivitamins K Phase 3
27 Aspirin, Dipyridamole Drug Combination Phase 3
28 Antithrombin III Phase 3,Phase 2
29 Antithrombins Phase 3,Phase 2
30 serine Nutraceutical Phase 3,Phase 2
31
Heparin Approved, Investigational Phase 2 9005-49-6 46507594 772
32
Polidocanol Approved Phase 2 9002-92-0
33
Dalteparin Approved Phase 2 9005-49-6
34 calcium heparin Phase 2
35 Neurotransmitter Agents Phase 2
36 Heparin, Low-Molecular-Weight Phase 2
37 Anticonvulsants Phase 2
38 Antidepressive Agents Phase 2
39 Purinergic P2 Receptor Antagonists Phase 2
40 Purinergic P2Y Receptor Antagonists Phase 2
41 Calcium, Dietary Phase 2
42
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
43
Iodine Approved, Investigational 7553-56-2 807
44
Nitric Oxide Approved 10102-43-9 145068
45
Vitamin C Approved, Nutraceutical 50-81-7 54670067 5785
46 Tocopherol Approved, Investigational, Nutraceutical
47
Vitamin E Approved, Nutraceutical, Vet_approved 59-02-9 14985
48 tannic acid Approved, Nutraceutical
49
N,N-dimethylarginine Experimental 30315-93-6 123831
50 Micronutrients

Interventional clinical trials:

(show top 50) (show all 75)

# Name Status NCT ID Phase Drugs
1 PC-Trial: Patent Foramen Ovale and Cryptogenic Embolism Unknown status NCT00166257 Phase 4 Medical antitrhombotic treatment
2 Atrial Fibrillation Ablation Compared to Rate Control Strategy in Patients With Impaired Left Ventricular Function Unknown status NCT02509754 Phase 4
3 Patent Foramen Ovale in Cryptogenic Stroke Study Completed NCT00697151 Phase 4 Warfarin;Aspirin
4 Device Closure Versus Medical Therapy for Cryptogenic Stroke Patients With High-Risk Patent Foramen Ovale (DEFENSE-PFO) Recruiting NCT01550588 Phase 4 Standard medical treatment
5 Evaluation of the STARFlex® Septal Closure System in Patients With a Stroke or TIA Due to the Possible Passage of a Clot of Unknown Origin Through a Patent Foramen Ovale (PFO) Unknown status NCT00201461 Phase 2, Phase 3 Best medical therapy
6 MIST II PFO-Migraine Trial With BioSTAR® Bioabsorbable Septal Repair Implant Unknown status NCT00283738 Phase 2, Phase 3
7 Patent Foramen Ovale Closure or Anticoagulants Versus Antiplatelet Therapy to Prevent Stroke Recurrence Completed NCT00562289 Phase 3 aspirin;Antivitamins K or rivaroxaban or dabigatran or apixaban
8 Medtronic Concomitant Utilization of Radio Frequency for Atrial Fibrillation CURE-AF/Persistent Completed NCT00506493 Phase 3
9 Concomitant Utilization of Radio Frequency Energy for Atrial Fibrillation (CURE-AF) Study Completed NCT00431834 Phase 3
10 Cardiox Shunt Detection Technology Study Terminated NCT01333761 Phase 3
11 Right to Left Cardiac Shunt Detection Terminated NCT01773252 Phase 3
12 ESCAPE Migraine Trial Terminated NCT00267371 Phase 3 Medical management/current medications per standard of care by personal physician.
13 Premium Migraine Trial Completed NCT00355056 Phase 2
14 Safety Study of Varisolve® Procedure for Treatment of Varicose Veins in Patients With Right-to-left Cardiac Shunt Completed NCT00442364 Phase 2 Polidocanol (1%) Microfoam (Varisolve)
15 Precutaneous High Risk Patent Foramen Ovale to Treat Migraine Headaches Recruiting NCT02777359 Phase 2
16 RESPECT PFO Clinical Trial Active, not recruiting NCT00465270 Phase 2
17 PRIMA PFO Migraine Trial Terminated NCT00505570 Phase 2
18 Catheter Thrombectomy in Patients With Massive Pulmonary Embolism Terminated NCT00314002 Phase 1, Phase 2
19 Patients With Patent Foramen Ovale and Endocardial Device Leads on Apixaban for Prevention of Paradoxical Emboli Withdrawn NCT02378623 Phase 2 Apixaban;Placebo
20 Influence of Position on Detection of Patent Foramen Ovale by Simultaneous Transesophageal Echo and Transcranial Doppler Unknown status NCT02383836
21 Timing of Closure of Patent Foramen Ovale Following Birth Unknown status NCT01032785
22 Prospective Clinical Follow-up After the Percutaneous Closure of a Patent Foramen Ovale Unknown status NCT01149447
23 Occluder Size Determination in Transcatheter ASD II Closure Based on 3D TEE Assessment Unknown status NCT02601768
24 Paradigm I Clinical Trial: Study of the PFX Closure System in Subjects With Cryptogenic Stroke, Transient Ischemia Attack or Paradoxical Embolism Unknown status NCT00196027
25 InterSEPT: In‐Tunnel SeptRx European PFO Trial Unknown status NCT01385670
26 Chronic Mountain Sickness, Systemic Vascular Function Unknown status NCT01182792
27 Clinical Proteomic Research for the Brain Unknown status NCT00983723
28 Comorbidities Associated With Migraine and Patent Foramen Ovale (CAMP) Completed NCT01257880
29 Pulmonary Embolism and Stroke in Patient With Patent Foramen Ovale Completed NCT01216423
30 Residual Shunt After Patent Foramen Ovale Device Closure in Patients With Cryptogenic Stroke Completed NCT03416426
31 Effectiveness and Safety of Transcatheter Patent Foramen Ovale Closure for Migraine Completed NCT02127294
32 Safety and Effectiveness Study of the Solysafe Septal Occluder in Patients With Atrial Septum Defect and Patent Foramen Ovale Completed NCT00207376
33 Risk of Stroke in Pulmonary Embolism With a Patent Foramen Ovale (PFO) Completed NCT00831259
34 Patent Foramen Ovale and the Risk of Postoperative Delirium Following Elective Hip and Knee Arthroplasty Surgeries Completed NCT02400892
35 Nitrogen Bubble Detection After Simulated Dives in Divers With PFO and After PFO Closure Completed NCT01854281
36 Impact Of Closure Of Patent Foramen Ovale On Apnoea-Hypopnoea-Index, Nocturnal Hypoxemia And Systemic Vascular Function In Patients With Obstructive Sleep Apnoea Completed NCT01780207
37 Patent Foramen Ovale in Children With Migraine Headaches Completed NCT00750594
38 Procedural Success and Safety of the Nit-Occlud® Patent Foramen Ovale (PFO) Closure Device and Its Application System Completed NCT00968032
39 GORE® Septal Occluder European Union Clinical Evaluation Completed NCT01605851
40 Correlation of Right-left Shunt Detection in Cardioembolism Etiology in Stroke Patient. Completed NCT02351076
41 Cardiac Troponin T After Transcatheter Closure of the Interatrial Septum Completed NCT03099967
42 Long-term Safety Study of the GORE® HELEX® Septal Occluder Completed NCT00581308
43 Biomarkers, Hemodynamic and Echocardiographic Predictors of Ischemic Strokes and Their Influence on the Course and Prognosis Completed NCT03377465
44 The Paradigm II Trial: PFX Closure System in Subjects With Cryptogenic Stroke, Transient Ischemic Attack, Migraine or Decompression Illness Completed NCT00196040
45 Semi-automatic assessMent of Aortic Roots by Three-dimensional transoEsophageal echocaRdiography (SMARTER) Completed NCT02724709
46 Surgical Tourniquets and Cerebral Emboli Completed NCT02240732
47 Identification the Cause of Silent Cerebral infarctiON in Healthy Subjects (ICONS) Completed NCT01429948
48 PFO Closure for Obstructive Sleep Apnoea Recruiting NCT02771561
49 Post Market Clinical Follow-up Study of IrisFITTM PFO (Patent Foramen Ovale) Occluder Recruiting NCT02882815
50 Decompression Sickness in Divers With or Without Patent Foramen Ovale Recruiting NCT02432131

Search NIH Clinical Center for Patent Foramen Ovale

Cochrane evidence based reviews: foramen ovale, patent

Genetic Tests for Patent Foramen Ovale

Genetic tests related to Patent Foramen Ovale:

# Genetic test Affiliating Genes
1 Patent Foramen Ovale 28

Anatomical Context for Patent Foramen Ovale

MalaCards organs/tissues related to Patent Foramen Ovale:

38
Heart, Lung, Brain, Spinal Cord, Liver, Testes, Endothelial

Publications for Patent Foramen Ovale

Articles related to Patent Foramen Ovale:

(show top 50) (show all 752)
# Title Authors Year
1
Tissue Plasminogen Activator to Treat a Stroke after Foam Sclerotherapy in a Woman with a Patent Foramen Ovale. ( 29402614 )
2018
2
Closure of Patent Foramen Ovale Versus Medical Therapy in Patients With Cryptogenic Stroke or Transient Ischemic Attack: Updated Systematic Review and Meta-Analysis. ( 29335335 )
2018
3
Adding patent foramen ovale closure to antiplatelet therapy reduced stroke after cryptogenic stroke. ( 29335719 )
2018
4
Is Patent Foramen Ovale a Risk Factor for Perioperative Stroke? ( 29411017 )
2018
5
Quality of life after percutaneous closure of patent foramen ovale in patients after cryptogenic stroke compared to a normative sample. ( 29422265 )
2018
6
Closure of patent foramen ovale for cryptogenic stroke patients: an updated systematic review and meta-analysis of randomized trials. ( 29383514 )
2018
7
Patent foramen ovale closure vs. medical therapy for recurrent stroke prevention: Evolution of treatment effect during follow-up. ( 29338916 )
2018
8
Paradoxical emboli following a pulmonary embolus in the presence of a patent foramen ovale. ( 29404367 )
2018
9
Multiple Cerebral Infarctions Due to Patent Foramen Ovale in a Patient with Eosinophilic Granulomatosis with Polyangiitis. ( 29373226 )
2018
10
Patent foramen ovale closure versus medical therapy in cases with cryptogenic stroke, meta-analysis of randomized controlled trials. ( 29356972 )
2018
11
A rare case of paradoxical embolism from tricuspid valve infective endocarditis and patent foramen ovale. ( 29372516 )
2018
12
The use of point-of-care ultrasound to diagnose patent foramen ovale in elective hip and knee arthroplasty patients and its association with postoperative delirium. ( 29368313 )
2018
13
Intracardiac echocardiography for percutaneous patent foramen ovale and atrial septal defect occlusion. ( 29374291 )
2018
14
Adding patent foramen ovale closure to antiplatelet drugs reduced ischemic stroke after cryptogenic stroke. ( 29335718 )
2018
15
Association of Preoperatively Diagnosed Patent Foramen Ovale With Perioperative Ischemic Stroke. ( 29411032 )
2018
16
Patent Foramen Ovale Repair at the Time of Double Lung Transplantation: Necessary or Not? ( 29349838 )
2018
17
Patent Foramen Ovale Closure for Hypoxemia. ( 28886845 )
2017
18
Patent Foramen Ovale after Cryptogenic Stroke - Assessing the Evidence for Closure. ( 28902595 )
2017
19
Patent Foramen Ovale and Migraine Headache. ( 28886844 )
2017
20
Transcatheter Closure of Patent Foramen Ovale: Devices and Technique. ( 28886846 )
2017
21
Patent foramen ovale and anticardiolipin antibodies, a strange cause of bilateral kidney infarcion. ( 28826574 )
2017
22
An unusual combination of patent foramen ovale with pulmonary arteriovenous malformation in a young patient with stroke. ( 28681775 )
2017
23
Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke. ( 28902590 )
2017
24
Tipping Point for Patent Foramen Ovale Closure. ( 28902592 )
2017
25
Imaging Assessment of the Interatrial Septum for Transcatheter Atrial Septal Defect and Patent Foramen Ovale Closure. ( 28886842 )
2017
26
Ischemic Stroke in a Patient With Quadricuspid Aortic Valve and Patent Foramen Ovale. ( 28868103 )
2017
27
Comparison of Different Contrast Agents in Detecting Cardiac Right-to-Left Shunt in Patients with a Patent Foramen Ovale during Contrast-Transthoracic Echocardiography. ( 29333447 )
2017
28
Cryptogenic Stroke and Patent Foramen Ovale Risk Assessment. ( 28886840 )
2017
29
Current Dataset for Patent Foramen Ovale Closure in Cryptogenic Stroke: Randomized Clinical Trials and Observational Studies. ( 28886843 )
2017
30
Transcatheter Closure of Patent Foramen Ovale. ( 28886847 )
2017
31
When to use femoral vein injection for diagnosis of patent foramen ovale-Effect of a persistent eustachian valve on right atrial flow patterns during contrast transesophageal echocardiography. ( 28299822 )
2017
32
Concomitant coronary and pulmonary embolism associated with patent foramen ovale: A case report. ( 29384941 )
2017
33
Patent Foramen Ovale Closure or Antiplatelet Therapy for Cryptogenic Stroke. ( 28902580 )
2017
34
Effect of patent foramen ovale closure for prevention on recurrent stroke or transient ischemic attack in selected patients with cryptogenic stroke. ( 28833599 )
2017
35
Safety Outcomes After Percutaneous Transcatheter Closure of Patent Foramen Ovale. ( 28939677 )
2017
36
Patent Foramen Ovale (PFO), Personality Traits, and Iterative Decompression Sickness. Retrospective Analysis of 209 Cases. ( 28824507 )
2017
37
Identification and Quantification of Patent Foramen Ovale-Mediated Shunts: Echocardiography and Transcranial Doppler. ( 28886841 )
2017
38
Patent Foramen Ovale Closure or Anticoagulation vs. Antiplatelets after Stroke. ( 28902593 )
2017
39
Effect of a patent foramen ovale in humans on thermal responses to passive cooling and heating. ( 28819008 )
2017
40
A Case of Shunting Postoperative Patent Foramen Ovale Under Mechanical Ventilation Controlled by Different Ventilator Settings. ( 28855978 )
2017
41
Cochleovestibular Transient Ischemic Attack as a Manifestation of Patent Foramen Ovale. ( 29360095 )
2017
42
Clinical outcomes and a high prevalence of abnormalities on comprehensive arterial and venous thrombophilia screening in TIA or ischaemic stroke patients with a patent foramen ovale, an inter-atrial septal aneurysm or both. ( 28477701 )
2017
43
Patent Foramen Ovale and Cryptogenic Strokes in the Stroke in Young Fabry Patients Study. ( 27899752 )
2017
44
Recent development of transcatheter closure of atrial septal defect and patent foramen ovale with occluders. ( 28024095 )
2016
45
Paradoxical Embolus Stuck in a Patent Foramen Ovale. ( 28018828 )
2016
46
Unexpected perforation leading to life-threatening cardiac tamponade six years after patent foramen ovale closure with an intrasept device. ( 27090049 )
2016
47
Case report: Renal infarction by paradoxical embolism through the patent foramen ovale as an unusual cause of post-operative abdominal pain after sleeve gastrectomy. ( 27449763 )
2016
48
The role of coronary CT angiography in diagnosis of patent foramen ovale. ( 27152642 )
2016
49
Intracardiac thrombus trapped in a patent foramen ovale. ( 27173872 )
2016
50
Patent foramen ovale. ( 27188965 )
2016

Variations for Patent Foramen Ovale

ClinVar genetic disease variations for Patent Foramen Ovale:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 AAR2 NM_015511.4(AAR2): c.520G> A (p.Val174Met) single nucleotide variant Likely pathogenic rs746800707 GRCh37 Chromosome 20, 34828310: 34828310
2 Translocation Likely pathogenic
3 46;XX;inv(7)(q21.2q34) inversion Likely pathogenic

Expression for Patent Foramen Ovale

Search GEO for disease gene expression data for Patent Foramen Ovale.

Pathways for Patent Foramen Ovale

GO Terms for Patent Foramen Ovale

Cellular components related to Patent Foramen Ovale according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.56 F2 F5 FGA SERPINC1
2 platelet alpha granule GO:0031091 9.16 F5 FGA
3 macromolecular complex GO:0032991 8.96 NKX2-5 TBX5
4 blood microparticle GO:0072562 8.92 ACTC1 F2 FGA SERPINC1

Biological processes related to Patent Foramen Ovale according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.95 CITED2 EDNRA NKX2-5 TBX5
2 in utero embryonic development GO:0001701 9.94 CITED2 EDNRA GATA6 MYH6
3 cellular protein metabolic process GO:0044267 9.93 F2 F5 FGA GATA6 SERPINC1
4 male gonad development GO:0008584 9.85 CITED2 GATA4 GATA6
5 outflow tract morphogenesis GO:0003151 9.8 CITED2 NKX2-5 TBX20
6 cardiac muscle contraction GO:0060048 9.78 ACTC1 MYH6 NKX2-5
7 blood circulation GO:0008015 9.77 F5 MTHFR TBX20
8 heart looping GO:0001947 9.76 CITED2 GATA4 NKX2-5 TBX20
9 positive regulation of cardiac muscle cell proliferation GO:0060045 9.75 GATA6 TBX20 TBX5
10 ventricular septum development GO:0003281 9.73 CITED2 GATA4 TBX5
11 outflow tract septum morphogenesis GO:0003148 9.72 GATA6 NKX2-5 TBX20
12 fibrinolysis GO:0042730 9.7 F12 F2 FGA
13 blood coagulation, intrinsic pathway GO:0007597 9.69 APOH F12 F2
14 actin filament-based movement GO:0030048 9.68 ACTC1 MYH6
15 heart contraction GO:0060047 9.67 ACTC1 NKX2-5
16 cardiac muscle hypertrophy in response to stress GO:0014898 9.67 GATA6 MYH6
17 cardiac muscle cell differentiation GO:0055007 9.67 GATA4 GATA6 NKX2-5 TBX5
18 adult heart development GO:0007512 9.66 MYH6 NKX2-5
19 cardiac right ventricle morphogenesis GO:0003215 9.66 GATA4 TBX20
20 plasminogen activation GO:0031639 9.65 APOH FGA
21 negative regulation of fibrinolysis GO:0051918 9.65 APOH F2
22 positive regulation of blood coagulation GO:0030194 9.65 APOH F12 F2
23 hemostasis GO:0007599 9.65 F12 F2 F5 FGA SERPINC1
24 cardiac ventricle morphogenesis GO:0003208 9.64 GATA4 NKX2-5
25 intestinal epithelial cell differentiation GO:0060575 9.63 GATA4 GATA6
26 Type II pneumocyte differentiation GO:0060510 9.62 GATA6 NKX2-1
27 regulation of blood coagulation GO:0030193 9.62 APOH F12 F2 SERPINC1
28 lung saccule development GO:0060430 9.61 GATA6 NKX2-1
29 cardiac muscle tissue morphogenesis GO:0055008 9.61 ACTC1 NKX2-5 TBX20
30 Clara cell differentiation GO:0060486 9.59 GATA6 NKX2-1
31 embryonic heart tube left/right pattern formation GO:0060971 9.58 CITED2 NKX2-5
32 endocardial cushion development GO:0003197 9.58 CITED2 GATA4 TBX5
33 bundle of His development GO:0003166 9.57 NKX2-5 TBX5
34 blood coagulation GO:0007596 9.5 F12 F2 F5 FGA GATA4 GATA6
35 atrial septum morphogenesis GO:0060413 9.46 GATA4 NKX2-5 TBX20 TBX5
36 positive regulation of cardioblast differentiation GO:0051891 8.92 GATA4 GATA6 NKX2-5 TBX5
37 positive regulation of transcription by RNA polymerase II GO:0045944 10.18 CITED2 GATA4 GATA6 NKX2-1 NKX2-5 TBX20
38 negative regulation of transcription, DNA-templated GO:0045892 10.06 CITED2 GATA6 NKX2-1 NKX2-5 TBX20
39 positive regulation of transcription, DNA-templated GO:0045893 10.04 CITED2 GATA4 GATA6 NKX2-1 NKX2-5 TBX20

Molecular functions related to Patent Foramen Ovale according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.8 GATA4 GATA6 NKX2-1 NKX2-5 TBX5
2 DNA binding transcription factor activity GO:0003700 9.7 CITED2 GATA4 GATA6 NKX2-1 NKX2-5 TBX20
3 transcription regulatory region DNA binding GO:0044212 9.67 GATA4 GATA6 NKX2-1 NKX2-5
4 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.62 GATA4 GATA6 NKX2-1 TBX20
5 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003705 9.43 GATA6 NKX2-1 NKX2-5
6 RNA polymerase II transcription factor binding GO:0001085 9.13 GATA4 GATA6 TBX20
7 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0001228 8.92 GATA4 GATA6 NKX2-5 TBX5

Sources for Patent Foramen Ovale

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
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33 ICD10 via Orphanet
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60 QIAGEN
65 SNOMED-CT via HPO
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68 Tocris
69 UMLS
70 UMLS via Orphanet
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