Patent Foramen Ovale

Categories: Rare diseases, Cardiovascular diseases, Fetal diseases

Aliases & Classifications for Patent Foramen Ovale

MalaCards integrated aliases for Patent Foramen Ovale:

Name: Patent Foramen Ovale 12 56 29 14
Foramen Ovale, Patent 42 69
Foramen Ovale Patent 12 52
Defect, Patent or Persistent, Ostium Secundum 12
Atrial Septal Defect, Ostium Secundum Type 56
Ostium Secundum Type Atrial Septal Defect 12
Atrial Septal Defect Within Oval Fossa 12
Ostium Secundum Atrial Septal Defect 50
Persistent Ostium Secundum 12
Asd, Ostium Secundum Type 56
Asd Ostium Secundum Type 50
Ostium Secundum Asd 50
Osasd 50


External Ids:

Disease Ontology 12 DOID:13620
ICD10 33 Q21.1
MeSH 42 D054092
NCIt 47 C34619
MESH via Orphanet 43 D054092
UMLS via Orphanet 70 C0016522 C0344724
ICD10 via Orphanet 34 Q21.1
UMLS 69 C0016522

Summaries for Patent Foramen Ovale

NIH Rare Diseases : 50 an ostium secundum atrial septal defect is a type of congenital heart defect called an atrial septal defect (asd). an asd is a hole in the wall (septum) between the two upper chambers of the heart (the atria). asds can be classified by location. an ostium secundum asd is a hole in the center of the atrial septum. normally, the right side of the heart pumps oxygen-poor blood to the lungs, while the left side pumps oxygen-rich blood to the body. an asd allows blood from both sides to mix, causing the heart to work less efficiently. a small hole may not cause any symptoms or problems. a larger hole can eventually cause symptoms such as shortness of breath, respiratory infections, fainting, irregular heart rhythms or fatigue after mild activity. larger asds can also ultimately lead to pulmonary artery hypertension, right ventricular hypertrophy (enlargement); svt, or heart failure. most cases of asd are not inherited and occur by chance. some cases appear to have autosomal dominant inheritance. treatment may not be needed for small asds, which often close on their own. larger asds are typically closed during childhood with open heart surgery or by cardiac catheterization. last updated: 8/4/2016

MalaCards based summary : Patent Foramen Ovale, also known as foramen ovale, patent, is related to central retinal artery occlusion and myocardial infarction. An important gene associated with Patent Foramen Ovale is NKX2-5 (NK2 Homeobox 5), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Aspirin and Warfarin have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Patent Foramen Ovale

Diseases related to Patent Foramen Ovale via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 201)
id Related Disease Score Top Affiliating Genes
1 central retinal artery occlusion 31.1 APOH F2 MTHFR SERPINC1
2 myocardial infarction 30.9 F13A1 F2 F5 GATA4 MTHFR SERPINC1
3 aortic aneurysm 30.8 ACTC1 F13A1
4 budd-chiari syndrome 30.7 APOH F2 F5 MTHFR SERPINC1
5 hypoplastic left heart syndrome 11.5
6 mental retardation and distinctive facial features with or without cardiac defects 11.3
7 tricuspid atresia 11.1
8 right ventricle hypoplasia 11.1
9 short stature, developmental delay, and congenital heart defects 11.1
10 multicentric osteolysis nephropathy 11.0 F5 MTHFR
11 mcgillivray syndrome 11.0 APOH F5
12 variably protease-sensitive prionopathy 11.0 F2 F5
13 coronary sinus stenosis 11.0 F5 MTHFR
14 accessory deep peroneal nerve 11.0 APOH F5
15 46,xy ovotesticular disorder of sex development 10.9 APOH F2 F5
16 primary pigmented nodular adrenocortical disease 10.9 F2 F5 MTHFR
17 homologous wasting disease 10.9 F2 F5 MTHFR
18 amelogenesis imperfecta hypomaturation type 10.9 F5 MTHFR
19 pregnancy loss, recurrent 1 10.9 APOH F5 MTHFR
20 cavernous lymphangioma 10.9 APOH F5 MTHFR
21 hepatocellular adenoma 10.9 F2 F5 MTHFR
22 testicular gonadoblastoma 10.9 F2 F5 SERPINC1
23 thrombomodulin anomalies, familial 10.9 F2 F5 MTHFR
24 elejalde disease 10.9 APOH F2 MTHFR
25 porphyria 10.9 F2 MTHFR
26 neuroaxonal dystrophy 10.9 F2 F5 SERPINC1
27 inferior vena cava interruption 10.8 GATA4 GATA6
28 egg allergy 10.8 F12 F2 SERPINC1
29 lymphatic system cancer 10.8 F2 MTHFR SERPINC1
30 stickler sydrome, type i, nonsyndromic ocular 10.8 APOH F5 SERPINC1
31 pasli disease 10.8 GATA4 GATA6
32 capillary hemangioma 10.8 F2 MTHFR SERPINC1
33 inherited blood coagulation disease 10.8 F13A1 F2 F5
34 spinocerebellar ataxia 27 10.8 F2 F5 SERPINC1
35 tracheo-esophageal fistula-hypospadias syndrome 10.8 ACTC1 F13A1
36 pyridoxine deficiency anemia 10.8 F2 SERPINC1
37 otopalatodigital syndrome, type i 10.8 F2 F5 SERPINC1
38 fragile x syndrome type 2 10.8 F2 SERPINC1
39 bernard-soulier syndrome, type a2 10.8 F2 MTHFR SERPINC1
40 landau-kleffner syndrome 10.8 APOH F2
41 lockwood feingold syndrome 10.8 APOH F2 F5 MTHFR
42 brill-zinsser disease 10.8 F2 F5 SERPINC1
43 charcot-marie-tooth disease 10.8 F2 F5 MTHFR
44 ovarian insufficiency, familial 10.8 F2 MTHFR SERPINC1
45 ischemic heart disease 10.8 APOH F2 SERPINC1
46 exophthalmic ophthalmoplegia 10.8 APOH F5 SERPINC1
47 perichondritis of auricle 10.8 F2 F5 SERPINC1
48 stoll alembik finck syndrome 10.8 F5 SERPINC1
49 superior limbic keratoconjunctivitis 10.8 F2 F5 MTHFR SERPINC1
50 follicular adenoma 10.8 F2 F5 MTHFR SERPINC1

Graphical network of the top 20 diseases related to Patent Foramen Ovale:

Diseases related to Patent Foramen Ovale

Symptoms & Phenotypes for Patent Foramen Ovale

MGI Mouse Phenotypes related to Patent Foramen Ovale:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.41 ACTC1 CITED2 EDNRA F13A1 F2 F5
2 homeostasis/metabolism MP:0005376 10.39 F12 F13A1 F2 F5 GATA4 GATA6
3 mortality/aging MP:0010768 10.32 TBX5 TKT TLL1 ACTC1 APOH CITED2
4 growth/size/body region MP:0005378 10.3 ACTC1 CITED2 EDNRA F2 F5 GATA4
5 embryo MP:0005380 10.18 CITED2 EDNRA F2 F5 GATA4 GATA6
6 digestive/alimentary MP:0005381 10.04 GATA4 NKX2-1 NKX2-5 TLL1 CITED2 EDNRA
7 nervous system MP:0003631 10 NKX2-5 SERPINC1 TKT EDNRA F12 F2
8 muscle MP:0005369 9.97 ACTC1 EDNRA GATA4 GATA6 MYH6 NKX2-5
9 normal MP:0002873 9.9 ACTC1 CITED2 EDNRA F12 F2 GATA4
10 liver/biliary system MP:0005370 9.88 F5 GATA4 GATA6 SERPINC1 TKT TLL1
11 reproductive system MP:0005389 9.61 F12 F13A1 F2 GATA4 GATA6 MTHFR
12 respiratory system MP:0005388 9.23 CITED2 EDNRA F13A1 F2 GATA4 GATA6

Drugs & Therapeutics for Patent Foramen Ovale

Drugs for Patent Foramen Ovale (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
id Name Status Phase Clinical Trials Cas Number PubChem Id
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-78-2 2244
Warfarin Approved Phase 4,Phase 2,Phase 3 81-81-2 6691 54678486
Clopidogrel Approved, Nutraceutical Phase 4,Phase 3,Phase 2 120202-66-6, 113665-84-2 60606
4 Analgesics Phase 4,Phase 2,Phase 3
5 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3
6 Antipyretics Phase 4,Phase 2,Phase 3
7 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
8 Anticoagulants Phase 4,Phase 3,Phase 2
9 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
10 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2
11 Antirheumatic Agents Phase 4,Phase 3,Phase 2
12 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2
13 Fibrinolytic Agents Phase 4,Phase 3,Phase 2
14 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2
15 Coagulants Phase 4
Acetaminophen Approved Phase 2, Phase 3 103-90-2 1983
Apixaban Approved Phase 3,Phase 2 503612-47-3 10182969
Dipyridamole Approved Phase 3,Phase 2 58-32-2 3108
Rivaroxaban Approved Phase 3 366789-02-8
20 Antithrombin III Phase 3,Phase 2
21 Antithrombins Phase 3,Phase 2
22 Antivitamins K Phase 3
23 Aspirin, Dipyridamole Drug Combination Phase 3
24 Dabigatran Phase 3
25 Factor Xa Inhibitors Phase 3,Phase 2
26 HIV Protease Inhibitors Phase 3,Phase 2
protease inhibitors Phase 3,Phase 2
28 Serine Proteinase Inhibitors Phase 3,Phase 2
29 Pharmaceutical Solutions Phase 3,Phase 2
30 serine Nutraceutical Phase 3,Phase 2
Polidocanol Approved Phase 2 9002-92-0
Dalteparin Approved Phase 2 9005-49-6
Heparin Approved, Investigational Phase 2 9005-49-6 772 46507594
34 Anticonvulsants Phase 2
35 Antidepressive Agents Phase 2
36 calcium heparin Phase 2
37 Calcium, Dietary Phase 2
38 Heparin, Low-Molecular-Weight Phase 2
39 Neurotransmitter Agents Phase 2
40 Purinergic P2 Receptor Antagonists Phase 2
41 Purinergic P2Y Receptor Antagonists Phase 2
Nitric Oxide Approved 10102-43-9 145068
43 Tocopherol Approved, Nutraceutical
Vitamin C Approved, Nutraceutical 50-81-7 5785 54670067
Vitamin E Approved, Nutraceutical, Vet_approved 59-02-9 14985
Iodine Investigational 7553-56-2 807
47 Antioxidants
48 Micronutrients
49 Protective Agents
50 Tocopherols

Interventional clinical trials:

(show top 50) (show all 72)

id Name Status NCT ID Phase Drugs
1 PC-Trial: Patent Foramen Ovale and Cryptogenic Embolism Unknown status NCT00166257 Phase 4 Medical antitrhombotic treatment
2 Patent Foramen Ovale in Cryptogenic Stroke Study Completed NCT00697151 Phase 4 Warfarin;Aspirin
3 Long-term Safety Study of the GORE® HELEX® Septal Occluder Completed NCT00581308 Phase 4
4 Device Closure Versus Medical Therapy for Cryptogenic Stroke Patients With High-Risk Patent Foramen Ovale (DEFENSE-PFO) Recruiting NCT01550588 Phase 4 Standard medical treatment
5 Atrial Fibrillation Ablation Compared to Rate Control Strategy in Patients With Impaired Left Ventricular Function Not yet recruiting NCT02509754 Phase 4
6 Evaluation of the STARFlex® Septal Closure System in Patients With a Stroke or TIA Due to the Possible Passage of a Clot of Unknown Origin Through a Patent Foramen Ovale (PFO) Unknown status NCT00201461 Phase 2, Phase 3 Best medical therapy
7 MIST II PFO-Migraine Trial With BioSTAR® Bioabsorbable Septal Repair Implant Unknown status NCT00283738 Phase 2, Phase 3
8 Patent Foramen Ovale Closure or Anticoagulants Versus Antiplatelet Therapy to Prevent Stroke Recurrence Completed NCT00562289 Phase 3 aspirin;Antivitamins K or rivaroxaban or dabigatran or apixaban
9 Concomitant Utilization of Radio Frequency Energy for Atrial Fibrillation (CURE-AF) Study Completed NCT00431834 Phase 3
10 Medtronic Concomitant Utilization of Radio Frequency for Atrial Fibrillation CURE-AF/Persistent Completed NCT00506493 Phase 3
11 Cardiox Shunt Detection Technology Study Terminated NCT01333761 Phase 3
12 Right to Left Cardiac Shunt Detection Terminated NCT01773252 Phase 3
13 ESCAPE Migraine Trial Terminated NCT00267371 Phase 3 Medical management/current medications per standard of care by personal physician.
14 Premium Migraine Trial Completed NCT00355056 Phase 2
15 Safety Study of Varisolve® Procedure for Treatment of Varicose Veins in Patients With Right-to-left Cardiac Shunt Completed NCT00442364 Phase 2 Polidocanol (1%) Microfoam (Varisolve)
16 Precutaneous High Risk Patent Foramen Ovale to Treat Migraine Headaches Recruiting NCT02777359 Phase 2
17 RESPECT PFO Clinical Trial Active, not recruiting NCT00465270 Phase 2
18 PRIMA PFO Migraine Trial Terminated NCT00505570 Phase 2
19 Catheter Thrombectomy in Patients With Massive Pulmonary Embolism Terminated NCT00314002 Phase 1, Phase 2
20 Patients With Patent Foramen Ovale and Endocardial Device Leads on Apixaban for Prevention of Paradoxical Emboli Withdrawn NCT02378623 Phase 2 Apixaban;Placebo
21 Influence of Position on Detection of Patent Foramen Ovale by Simultaneous Transesophageal Echo and Transcranial Doppler Unknown status NCT02383836
22 Timing of Closure of Patent Foramen Ovale Following Birth Unknown status NCT01032785
23 Prospective Clinical Follow-up After the Percutaneous Closure of a Patent Foramen Ovale Unknown status NCT01149447
24 Paradigm I Clinical Trial: Study of the PFX Closure System in Subjects With Cryptogenic Stroke, Transient Ischemia Attack or Paradoxical Embolism Unknown status NCT00196027
25 InterSEPT: In‐Tunnel SeptRx European PFO Trial Unknown status NCT01385670
26 Chronic Mountain Sickness, Systemic Vascular Function Unknown status NCT01182792
27 Clinical Proteomic Research for the Brain Unknown status NCT00983723
28 Comorbidities Associated With Migraine and Patent Foramen Ovale (CAMP) Completed NCT01257880
29 Pulmonary Embolism and Stroke in Patient With Patent Foramen Ovale Completed NCT01216423
30 Safety and Effectiveness Study of the Solysafe Septal Occluder in Patients With Atrial Septum Defect and Patent Foramen Ovale Completed NCT00207376
31 Effectiveness and Safety of Transcatheter Patent Foramen Ovale Closure for Migraine Completed NCT02127294
32 Risk of Stroke in Pulmonary Embolism With a Patent Foramen Ovale (PFO) Completed NCT00831259
33 Patent Foramen Ovale and the Risk of Postoperative Delirium Following Elective Hip and Knee Arthroplasty Surgeries Completed NCT02400892
34 Nitrogen Bubble Detection After Simulated Dives in Divers With PFO and After PFO Closure Completed NCT01854281
35 Impact Of Closure Of Patent Foramen Ovale On Apnoea-Hypopnoea-Index, Nocturnal Hypoxemia And Systemic Vascular Function In Patients With Obstructive Sleep Apnoea Completed NCT01780207
36 Patent Foramen Ovale in Children With Migraine Headaches Completed NCT00750594
37 Procedural Success and Safety of the Nit-Occlud® Patent Foramen Ovale (PFO) Closure Device and Its Application System Completed NCT00968032
38 GORE® Septal Occluder European Union Clinical Evaluation Completed NCT01605851
39 Correlation of Right-left Shunt Detection in Cardioembolism Etiology in Stroke Patient. Completed NCT02351076
40 Cardiac Troponin T After Transcatheter Closure of the Interatrial Septum Completed NCT03099967
41 The Paradigm II Trial: PFX Closure System in Subjects With Cryptogenic Stroke, Transient Ischemic Attack, Migraine or Decompression Illness Completed NCT00196040
42 Semi-automatic assessMent of Aortic Roots by Three-dimensional transoEsophageal echocaRdiography (SMARTER) Completed NCT02724709
43 Surgical Tourniquets and Cerebral Emboli Completed NCT02240732
44 Identification the Cause of Silent Cerebral infarctiON in Healthy Subjects (ICONS) Completed NCT01429948
45 PFO Closure for Obstructive Sleep Apnoea Recruiting NCT02771561
46 Post Market Clinical Follow-up Study of IrisFITTM PFO (Patent Foramen Ovale) Occluder Recruiting NCT02882815
47 Decompression Sickness in Divers With or Without Patent Foramen Ovale Recruiting NCT02432131
48 International PFO Consortium Recruiting NCT00859885 Antithrombotic treatment
49 Occluder Size Determination in Transcatheter ASD II Closure Based on 3D TEE Assessment Recruiting NCT02601768
50 Lifetech CeraFlex™ Post-Market Surveillance Study Recruiting NCT02621528

Search NIH Clinical Center for Patent Foramen Ovale

Cochrane evidence based reviews: foramen ovale, patent

Genetic Tests for Patent Foramen Ovale

Genetic tests related to Patent Foramen Ovale:

id Genetic test Affiliating Genes
1 Patent Foramen Ovale 29

Anatomical Context for Patent Foramen Ovale

MalaCards organs/tissues related to Patent Foramen Ovale:

Heart, Lung, Brain, Liver, Spinal Cord, Testes, Endothelial

Publications for Patent Foramen Ovale

Articles related to Patent Foramen Ovale:

(show top 50) (show all 732)
id Title Authors Year
An unusual combination of patent foramen ovale with pulmonary arteriovenous malformation in a young patient with stroke. ( 28681775 )
Patent Foramen Ovale Closure or Anticoagulation vs. Antiplatelets after Stroke. ( 28902593 )
Clinical outcomes and a high prevalence of abnormalities on comprehensive arterial and venous thrombophilia screening in TIA or ischaemic stroke patients with a patent foramen ovale, an inter-atrial septal aneurysm or both. ( 28477701 )
Patent Foramen Ovale and Cryptogenic Strokes in the Stroke in Young Fabry Patients Study. ( 27899752 )
A Case of Shunting Postoperative Patent Foramen Ovale Under Mechanical Ventilation Controlled by Different Ventilator Settings. ( 28855978 )
Cryptogenic Stroke and Patent Foramen Ovale Risk Assessment. ( 28886840 )
Transcatheter Closure of Patent Foramen Ovale. ( 28886847 )
Patent Foramen Ovale Closure or Antiplatelet Therapy for Cryptogenic Stroke. ( 28902580 )
Current Dataset for Patent Foramen Ovale Closure in Cryptogenic Stroke: Randomized Clinical Trials and Observational Studies. ( 28886843 )
Effect of a patent foramen ovale in humans on thermal responses to passive cooling and heating. ( 28819008 )
Tipping Point for Patent Foramen Ovale Closure. ( 28902592 )
When to use femoral vein injection for diagnosis of patent foramen ovale-Effect of a persistent eustachian valve on right atrial flow patterns during contrast transesophageal echocardiography. ( 28299822 )
Safety Outcomes After Percutaneous Transcatheter Closure of Patent Foramen Ovale. ( 28939677 )
Patent Foramen Ovale after Cryptogenic Stroke - Assessing the Evidence for Closure. ( 28902595 )
Imaging Assessment of the Interatrial Septum for Transcatheter Atrial Septal Defect and Patent Foramen Ovale Closure. ( 28886842 )
Effect of patent foramen ovale closure for prevention on recurrent stroke or transient ischemic attack in selected patients with cryptogenic stroke. ( 28833599 )
Patent Foramen Ovale and Migraine Headache. ( 28886844 )
Patent Foramen Ovale Closure for Hypoxemia. ( 28886845 )
Transcatheter Closure of Patent Foramen Ovale: Devices and Technique. ( 28886846 )
Patent Foramen Ovale (PFO), Personality Traits, and Iterative Decompression Sickness. Retrospective Analysis of 209 Cases. ( 28824507 )
Ischemic Stroke in a Patient With Quadricuspid Aortic Valve and Patent Foramen Ovale. ( 28868103 )
Identification and Quantification of Patent Foramen Ovale-Mediated Shunts: Echocardiography and Transcranial Doppler. ( 28886841 )
Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke. ( 28902590 )
Patent foramen ovale and anticardiolipin antibodies, a strange cause of bilateral kidney infarcion. ( 28826574 )
To close or not to close: contemporary indications for patent foramen ovale closure. ( 27616622 )
Patent Foramen Ovale With Atrial Septal Aneurysm Is Strongly Associated With Migraine With Aura: A Large Observational Study. ( 27930349 )
The relationship of patent foramen ovale location with severity of stroke: A new risk factor for paradoxical embolism. ( 27075798 )
Propensity Score-Based Analysis of Percutaneous Closure Versus Medical Therapy in Patients With Cryptogenic Stroke and Patent Foramen Ovale: The IPSYS Registry (Italian Project on Stroke in Young Adults). ( 27582111 )
Patent foramen ovale: indications for closure and techniques. ( 27174117 )
Clinically apparent long-term electric disturbances in the acute and very long-term of patent foramen ovale device-based closure. ( 27847261 )
No Relationship Between Patent Foramen Ovale and Migraine Frequency. ( 27634435 )
Intracardiac thrombus trapped in a patent foramen ovale. ( 27173872 )
A very rare association between giant right atrial myxoma and patent foramen ovale. Extracellular matrix and morphological aspects: a case report. ( 27516037 )
Transient Ischemic Attack After Foam Sclerotherapy in a Woman With a Patent Foramen Ovale. ( 27111786 )
Closure of patent foramen ovale: do meta-analyses do justice? ( 27922929 )
Surgical Treatment for Thrombus Straddling a Patent Foramen Ovale. ( 27982351 )
Anaesthetic Management of Laparoscopic Morgagni Hernia Repair in a Patient with Coexisting Down Syndrome, Patent Foramen Ovale and Pectus Carinatum. ( 27366555 )
Hypoxemia associated with right-side cardiac tumor: right atrial lymphoma with patent foramen ovale. ( 27499989 )
Mid-term results of interventional closure of patent foramen ovale with the Occlutech Figulla(Ar) Flex II Occluder. ( 27832757 )
Percutaneous left atrial appendage closure through a patent foramen ovale evaluated by intraprocedural transesophageal echocardiography. ( 27178699 )
A benign patent foramen ovale in off-pump coronary artery bypass can suddenly take a right turn, but can it be tolerated? ( 27113620 )
Long-Term Outcomes and Complications of Intracardiac Echocardiography-Assisted Patent Foramen Ovale Closure in 1,000 Consecutive Patients. ( 27500752 )
Patent foramen ovale in idiopathic pulmonary arterial hypertension: Long-term risk and morbidity. ( 27578471 )
Economy Class Syndrome, Patent Foramen Ovale and Stroke. ( 27567137 )
Unresolved or Contradictory Issues About Management of Patients With Patent Foramen Ovale and Previous Cryptogenic Stroke: Additional Randomized Controlled Trials Are Eagerly Awaited. ( 27081420 )
Patent foramen ovale: a novel cardiovascular risk factor in patients with sleep disordered breathing and high altitude dwellers? ( 27878796 )
Visualization of atrial septal aneurysm and patent foramen ovale by three-dimensional transesophageal echocardiography. ( 28482355 )
Recurrent Stroke due to Patent Foramen Ovale Closure Device Thrombus Eight Years after Implantation. ( 27444520 )
Three-dimensional Echocardiography for Percutaneous Occlusion of Patent Foramen Ovale. ( 27027371 )
Sleep apnea syndrome and patent foramen ovale: a dangerous association in ischemic stroke? ( 27823712 )

Variations for Patent Foramen Ovale

ClinVar genetic disease variations for Patent Foramen Ovale:

id Gene Variation Type Significance SNP ID Assembly Location
1 AAR2 NM_015511.4(AAR2): c.520G> A (p.Val174Met) single nucleotide variant Likely pathogenic rs746800707 GRCh37 Chromosome 20, 34828310: 34828310
2 Translocation Likely pathogenic
3 46;XX;inv(7)(q21.2q34) inversion Likely pathogenic

Expression for Patent Foramen Ovale

Search GEO for disease gene expression data for Patent Foramen Ovale.

Pathways for Patent Foramen Ovale

GO Terms for Patent Foramen Ovale

Cellular components related to Patent Foramen Ovale according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 8.92 ACTC1 F13A1 F2 SERPINC1

Biological processes related to Patent Foramen Ovale according to GeneCards Suite gene sharing:

(show all 35)
id Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.95 CITED2 EDNRA NKX2-5 TBX5
2 cellular protein metabolic process GO:0044267 9.93 F2 F5 GATA6 SERPINC1
3 in utero embryonic development GO:0001701 9.8 EDNRA GATA6 MYH6
4 outflow tract morphogenesis GO:0003151 9.78 CITED2 NKX2-5 TBX20
5 cardiac muscle contraction GO:0060048 9.77 ACTC1 MYH6 NKX2-5
6 blood circulation GO:0008015 9.76 F5 MTHFR TBX20
7 positive regulation of cardiac muscle cell proliferation GO:0060045 9.73 GATA6 TBX20 TBX5
8 outflow tract septum morphogenesis GO:0003148 9.71 GATA6 NKX2-5 TBX20
9 blood coagulation, intrinsic pathway GO:0007597 9.69 APOH F12 F2
10 male gonad development GO:0008584 9.67 GATA4 GATA6
11 cardiac muscle cell differentiation GO:0055007 9.67 GATA4 GATA6 NKX2-5 TBX5
12 heart contraction GO:0060047 9.66 ACTC1 NKX2-5
13 cardiac right ventricle morphogenesis GO:0003215 9.65 GATA4 TBX20
14 adult heart development GO:0007512 9.65 MYH6 NKX2-5
15 positive regulation of blood coagulation GO:0030194 9.65 APOH F12 F2
16 hemostasis GO:0007599 9.65 F12 F13A1 F2 F5 SERPINC1
17 negative regulation of fibrinolysis GO:0051918 9.64 APOH F2
18 cardiac ventricle morphogenesis GO:0003208 9.64 GATA4 NKX2-5
19 heart looping GO:0001947 9.63 GATA4 NKX2-5 TBX20
20 intestinal epithelial cell differentiation GO:0060575 9.62 GATA4 GATA6
21 regulation of blood coagulation GO:0030193 9.62 APOH F12 F2 SERPINC1
22 lung saccule development GO:0060430 9.61 GATA6 NKX2-1
23 cardiac muscle tissue morphogenesis GO:0055008 9.61 ACTC1 NKX2-5 TBX20
24 Type II pneumocyte differentiation GO:0060510 9.6 GATA6 NKX2-1
25 Clara cell differentiation GO:0060486 9.58 GATA6 NKX2-1
26 embryonic heart tube left/right pattern formation GO:0060971 9.57 CITED2 NKX2-5
27 ventricular septum development GO:0003281 9.55 GATA4 TBX5
28 bundle of His development GO:0003166 9.52 NKX2-5 TBX5
29 blood coagulation GO:0007596 9.5 F12 F13A1 F2 F5 GATA4 GATA6
30 atrial septum morphogenesis GO:0060413 9.46 GATA4 NKX2-5 TBX20 TBX5
31 endocardial cushion development GO:0003197 9.4 GATA4 TBX5
32 positive regulation of cardioblast differentiation GO:0051891 8.92 GATA4 GATA6 NKX2-5 TBX5
33 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10.17 CITED2 GATA4 GATA6 NKX2-1 NKX2-5 TBX20
34 negative regulation of transcription, DNA-templated GO:0045892 10.06 CITED2 GATA6 NKX2-1 NKX2-5 TBX20
35 positive regulation of transcription, DNA-templated GO:0045893 10.04 CITED2 GATA4 GATA6 NKX2-1 NKX2-5 TBX20

Molecular functions related to Patent Foramen Ovale according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.8 GATA4 GATA6 NKX2-1 NKX2-5 TBX5
2 transcription factor activity, sequence-specific DNA binding GO:0003700 9.7 CITED2 GATA4 GATA6 NKX2-1 NKX2-5 TBX20
3 transcription regulatory region DNA binding GO:0044212 9.67 GATA4 GATA6 NKX2-1 NKX2-5
4 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.62 GATA4 GATA6 NKX2-1 TBX20
5 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003705 9.43 GATA6 NKX2-1 NKX2-5
6 RNA polymerase II transcription factor binding GO:0001085 9.13 GATA4 GATA6 TBX20
7 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0001228 8.92 GATA4 GATA6 NKX2-5 TBX5

Sources for Patent Foramen Ovale

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
52 Novoseek
55 OMIM via Orphanet
59 PubMed
66 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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