MCID: PTN001
MIFTS: 52

Patent Foramen Ovale malady

Rare diseases, Cardiovascular diseases, Fetal diseases categories

Aliases & Classifications for Patent Foramen Ovale

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Sources:
9Disease Ontology, 11DISEASES, 47Orphanet, 60UMLS, 43Novoseek, 41NIH Rare Diseases, 33MeSH, 55SNOMED-CT, 38NCIt, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
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Patent Foramen Ovale, Aliases & Descriptions:

Name: Patent Foramen Ovale 9 11 47
Atrial Septal Defect, Ostium Secundum Type 41 47
Atrial Septal Defect Within Oval Fossa 9 60
Asd, Ostium Secundum Type 41 47
Foramen Ovale Patent 9 43
Ostium Secundum Type Atrial Septal Defect 9
Atrial Septal Defect Ostium Secundum 41
 
Persistent, Ostium Secundum 9
Persistent Ostium Secundum 9
Asd Ostium Secundum Type 41
Foramen Ovale, Patent 60
Ostium Secundum Asd 41
Defect, Patent 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Fetal diseases
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology9 DOID:13620
MeSH33 D054092
NCIt38 C34619
Orphanet47 99108, 99103
MESH via Orphanet34 D054092
ICD10 via Orphanet26 Q21.1
UMLS via Orphanet61 C0016522, C0344724

Summaries for Patent Foramen Ovale

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MalaCards based summary: Patent Foramen Ovale, also known as atrial septal defect, ostium secundum type, is related to pulmonary embolism and retinal artery occlusion. An important gene associated with Patent Foramen Ovale is NKX2-5 (NK2 homeobox 5), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and HOP Signaling. The compounds mucicarmine and coumarins have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and spinal cord, and related mouse phenotypes are muscle and respiratory system.

Related Diseases for Patent Foramen Ovale

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Diseases related to Patent Foramen Ovale via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary embolism31.8FGA, F5, APOH
2retinal artery occlusion31.7APOH
3myocardial infarction31.2FGA, GATA4, F5
4antiphospholipid syndrome31.1F5, APOH
5budd-chiari syndrome31.0APOH, F5
6thrombophilia31.0F12, APOH, F5, FGA
7ventricular septal defect31.0NKX2-5
8cerebrovascular disease30.9APOH, F12
9hyperhomocysteinemia30.8F5, APOH
10congenital heart disease30.5GATA4, NKX2-5
11aneurysm11.1
12migraine11.1
13atrial septal aneurysm11.1
14cerebritis10.9
15headache10.9
16migraine with aura10.8
17pulmonary hypertension10.7
18obstructive sleep apnea10.7
19retinitis10.7
20sleep apnea10.7
21atrial fibrillation10.6
22endocarditis10.6
23ischemia10.6
24tetralogy of fallot10.6NKX2-5
25acute cor pulmonale10.5
26acute respiratory distress syndrome10.5
27pulmonic stenosis10.5
28transposition of the great arteries10.5
29hypoxia10.5
30cor pulmonale10.5
31sneddon syndrome10.5APOH
32thrombophlebitis10.5APOH
33acute myocardial infarction10.5
34aortic atherosclerosis10.5
35arteriovenous fistula10.5
36atherosclerosis10.5
37arteriovenous malformation10.5
38branch retinal artery occlusion10.5
39central retinal artery occlusion10.5
40cor triatriatum10.5
41hemiplegic migraine10.5
42pulmonary arteriovenous malformation10.5
43spinal cord infarction10.5
44persistent eustachian valve10.5
45sternal cleft10.4
46thrombophilia due to antithrombin iii deficiency10.4APOH, F5
47mondor disease10.4APOH, F5
48factor xi deficiency, autosomal recessive10.4F12, F5
49hypoprothrombinemia10.4APOH, F5
50retinal vascular occlusion10.4F5, APOH

Graphical network of the top 20 diseases related to Patent Foramen Ovale:



Diseases related to patent foramen ovale

Symptoms for Patent Foramen Ovale

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Drugs & Therapeutics for Patent Foramen Ovale

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Drug clinical trials:

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Genetic Tests for Patent Foramen Ovale

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Anatomical Context for Patent Foramen Ovale

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MalaCards organs/tissues related to Patent Foramen Ovale:

31
Brain, Heart, Spinal cord, Liver, Lung, Testes, Endothelial

Animal Models for Patent Foramen Ovale or affiliated genes

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Publications for Patent Foramen Ovale

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Articles related to Patent Foramen Ovale:

(show top 50)    (show all 615)
idTitleAuthorsYear
1
A rare case of cryptogenic stroke with an incidental finding of patent foramen ovale. (25876305)
2015
2
Role of occlusive devices to prevent thromboembolism among persons with a patent foramen ovale and prior stroke. (25744863)
2015
3
Patent foramen ovale and gut ischemia in potential intestinal transplant recipients. (25221903)
2014
4
Decline in mean platelet volume in patients with patent foramen ovale undergoing percutaneous closure. (25192299)
2014
5
Is closure of patent foramen ovale to prevent ischaemic stroke ever justified? (24167203)
2013
6
Neonatal systemic thromboembolism secondary to ductus arteriosus aneurysm and patent foramen ovale. (21801317)
2013
7
Determination of the Optimum Number of Cardiac Cycles to Differentiate Intra-Pulmonary Shunt and Patent Foramen Ovale by Saline Contrast Two- and Three-Dimensional Echocardiography. (24028319)
2013
8
Current evidence for closure of a patent foramen ovale for cryptogenic stroke prevention. (24373020)
2013
9
Thrombus formation in a patent foramen ovale. (23528287)
2013
10
Death by patent foramen ovale in a soccer player. (23468450)
2013
11
Patent foramen ovale in severe obstructive sleep apnea: clinical features and effects of closure. (22924163)
2013
12
Neuroimaging findings in cryptogenic stroke patients with and without patent foramen ovale. (23339957)
2013
13
Patent Foramen Ovale and Migraine Attacks: A Systematic Review. (24355354)
2013
14
Management of the stroke patient with patent foramen ovale: new insights and persistent questions in the wake of recent randomized trials. (23715857)
2013
15
Neurosurgery in the Semisitting Position in Patients with a Patent Foramen Ovale. (23920299)
2013
16
A systematic review of closure versus medical therapy for preventing recurrent stroke in patients with patent foramen ovale and cryptogenic stroke or transient ischemic attack. (24300230)
2013
17
Follow-up to 'Cholecystectomy in the presence of a large patent foramen ovale: laparoscopic or open?'. (23541851)
2013
18
Patent foramen ovale and atrial septal aneurysm can cause ischemic stroke in patients with antiphospholipid syndrome. (22836909)
2013
19
Updating the evidence on patent foramen ovale closure versus medical therapy in patients with cryptogenic stroke: aa8^systematic review and comprehensive meta-analysis of 2,303 patients from three randomised trials and 2,231 patients from 11 observational studies. (24240356)
2013
20
Platypnoea-orthodeoxia in an elderly man with patent foramen ovale and dilated ascending aorta. (22089080)
2012
21
Platypnea-orthodeoxia syndrome related to right hemidiaphragmatic elevation and a 'stretched' patent foramen ovale. (23230257)
2012
22
Patent foramen ovale, dialysis and microembolization. (22487266)
2012
23
Secondary stroke prevention: patent foramen ovale, aortic plaque, and carotid stenosis. (22422912)
2012
24
Simultaneous myocardial infarction and ischaemic stroke secondary to paradoxical emboli through a patent foramen ovale. (22930890)
2012
25
Stress-induced cardiomyopathy after patent foramen ovale closure: what role did anesthesia play? (22633744)
2012
26
Prevalence of patent foramen ovale with right-to-left shunting in dogs with pulmonic stenosis. (22151278)
2012
27
Focal neurological deficit with tricuspid endocarditis and patent foramen ovale. (22878350)
2012
28
Transcranial Doppler quantification of residual shunt after percutaneous patent foramen ovale closure: correlation of device efficacy with intracardiac anatomic measures. (22364421)
2012
29
Can patent foramen ovale affect rehabilitation? The uncommon association of platypnea-orthodeoxia syndrome and stroke. (21468677)
2011
30
Electrocardiographic changes and arrhythmias following percutaneous atrial septal defect and patent foramen ovale device closure. (21563292)
2011
31
Evaluation of patent foramen ovale in young adults with cryptogenic stroke. (22577450)
2011
32
Transthoracic echocardiography guidance during percutaneous closure of patent foramen ovale. (21967656)
2011
33
Contrast transoesophageal echocardiography remains superior to contrast-enhanced cardiac magnetic resonance imaging for the diagnosis of patent foramen ovale. (21193485)
2011
34
Role of patent foramen ovale in migraine etiology and treatment: a review. (21827543)
2011
35
Explantation of patent foramen ovale closure devices: a multicenter survey. (21596333)
2011
36
Risk and fate of residual interatrial shunting after transcatheter closure of patent foramen ovale: a long term follow up study. (21345765)
2011
37
Usefulness of intravenously administered fluid replenishment for detection of patent foramen ovale by transesophageal echocardiography. (20854974)
2010
38
Late cardiac perforation after transcatheter closure of patent foramen ovale mimicking acute type a aortic dissection. (20417804)
2010
39
The association of patent foramen ovale transcatheter closure and psychological well-being. (20089005)
2010
40
Patent foramen ovale among patients with mild chronic obstructive pulmonary disease and unexplained hypoxia. (20345439)
2010
41
Acute myocardial infarction involving two coronary arteries due to a patent foramen ovale. (20676784)
2010
42
Patent foramen ovale and obstructive sleep apnea: a new association? (20451427)
2010
43
A case of platypnea-orthodeoxia syndrome caused by the interaction between the presence of corrected transposition of the great arteries and patent foramen ovale. (18706706)
2010
44
Paradoxical emboli--clinical importance of transcranial Doppler for detection of patent foramen ovale. (21443152)
2010
45
A third treatment option for entrapped thrombus in patent foramen ovale. (20548835)
2010
46
Lack of association between migraine headache and patent foramen ovale: results of a case-control study. (20231534)
2010
47
A gain-of-function TBX20 mutation causes congenital atrial septal defects, patent foramen ovale and cardiac valve defects. (19762328)
2010
48
No indication for patent foramen ovale closure in migraine. (19949472)
2009
49
Do common prothrombotic mutations influence the risk of cerebral ischaemia in patients with patent foramen ovale? Systematic review and meta-analysis. (19404532)
2009
50
That balloon atrial septostomy is associated with preoperative stroke in neonates with transposition of the great arteries is another powerful argument in favor of therapeutic closure of every patent foramen ovale. (16828611)
2006

Variations for Patent Foramen Ovale

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Expression for genes affiliated with Patent Foramen Ovale

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Search GEO for disease gene expression data for Patent Foramen Ovale.

Pathways for genes affiliated with Patent Foramen Ovale

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Pathways related to Patent Foramen Ovale according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0GATA4, NKX2-5
210.0GATA4, NKX2-5
310.0GATA4, GATA6
4
Show member pathways
9.7GATA4, GATA6, NKX2-5
5
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility58
Cytoskeleton remodeling Integrin outside in signaling58
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases58
Cell adhesion Tight junctions58
Development MAG dependent inhibition of neurite outgrowth58
9.4MYH6, ACTC1, NKX2-1
69.3NKX2-5, TBX20, GATA6, GATA4
79.0GATA4, TBX20, NKX2-5, ACTC1, MYH6
8
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
8.8FGA, F5, F12
9
Show member pathways
8.8F12, F5, FGA
10
Show member pathways
8.4TLL1, F12, F5, FGA
11
Show member pathways
8.3FGA, GATA4, GATA6, F5, F12

Compounds for genes affiliated with Patent Foramen Ovale

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Compounds related to Patent Foramen Ovale according to GeneCards Suite gene sharing:

(show all 40)
idCompoundScoreTop Affiliating Genes
1mucicarmine4310.0NKX2-1, ACTC1
2coumarins439.8APOH, F5
3b 723439.8ACTC1, NKX2-1
4methanol43 2410.7ACTC1, APOH
5hirugen439.6F5, FGA
6batroxobin439.6FGA, F5
7nafamostat mesilate439.6FGA, F5
8cardiolipin43 1210.6F5, APOH
9ancrod439.6FGA, F5
10bivalirudin43 1210.6FGA, F5
11argatroban43 1210.5F5, FGA
12kaolin439.5F5, APOH, F12
13kininogen439.5F5, APOH, F12
14cacl2439.5FGA, F5
1511-dehydrothromboxane b2439.5APOH, FGA
166-ketoprostaglandin f1alpha439.4FGA, APOH
17polyacrylamide439.4APOH, MYH6, F5
18ticlopidine43 1210.4APOH, FGA
19ptca439.4FGA, APOH
20progesterone43 28 59 24 1213.4GATA4, F5, ACTC1, APOH
21coumarin43 2 49 2412.3FGA, F5
22hirudin439.2FGA, F5
23phosphatidylethanolamine43 1210.2F5, APOH
24warfarin43 49 24 1212.1APOH, F5, FGA
25malondialdehyde439.1APOH, F5, FGA
26pge1439.0APOH, F5, FGA
27endotoxin439.0APOH, F5, FGA
28prostacyclin438.9FGA, F5, APOH
29nitric oxide43 24 1210.9APOH, NKX2-5, F5, GATA4
30retinoic acid43 249.8MYH6, ACTC1, NKX2-1, F5, GATA6, GATA4
31creatinine438.7FGA, F5, ACTC1, APOH
32zinc43 249.7F12, APOH, NKX2-5, NKX2-1, GATA6, GATA4
33aspirin43 49 28 2411.7F12, APOH, F5, FGA
34fibrinogen438.6F12, APOH, F5, FGA
35cholesterol43 28 24 1211.6FGA, GATA6, F5, APOH
36steroid438.6APOH, ACTC1, NKX2-1, F5, GATA6, GATA4
37heparin43 28 24 1211.6F12, APOH, F5, FGA
38estrogen438.2F12, APOH, MYH6, ACTC1, NKX2-1, F5
39calcium43 49 24 1211.0FGA, GATA4, F5, ACTC1, MYH6, APOH
40serine437.9F12, MYH6, NKX2-5, NKX2-1, F5, GATA4

GO Terms for genes affiliated with Patent Foramen Ovale

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Cellular components related to Patent Foramen Ovale according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sarcomereGO:00300179.9ACTC1, MYH6
2transcription factor complexGO:00056679.3NKX2-5, NKX2-1, GATA6
3extracellular spaceGO:00056158.0FGA, F5, ACTC1, APOH, F12
4nucleusGO:00056347.3CITED2, POLL, MYH6, NKX2-5, NKX2-1, TBX20

Biological processes related to Patent Foramen Ovale according to GeneCards Suite gene sharing:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1intestinal epithelial cell differentiationGO:006057510.3GATA6, GATA4
2embryonic heart tube left/right pattern formationGO:006097110.3NKX2-5, CITED2
3cardiac muscle hypertrophy in response to stressGO:001489810.3GATA4, GATA6
4endocardial cushion developmentGO:000319710.2GATA4, CITED2
5adult heart developmentGO:000751210.2NKX2-5, MYH6
6cardiac muscle cell differentiationGO:005500710.2GATA6, NKX2-5
7cardiac right ventricle morphogenesisGO:000321510.2TBX20, GATA4
8endoderm formationGO:000170610.2TBX20, GATA4
9positive regulation of cardioblast differentiationGO:005189110.1GATA4, GATA6, NKX2-5
10ventricular septum morphogenesisGO:006041210.1NKX2-5, CITED2
11sarcomere organizationGO:004521410.1MYH6, NKX2-5
12Clara cell differentiationGO:006048610.1GATA6, NKX2-1
13BMP signaling pathwayGO:003050910.1GATA4, NKX2-5, MYH6
14lung saccule developmentGO:006043010.0NKX2-1, GATA6
15Type II pneumocyte differentiationGO:006051010.0GATA6, NKX2-1
16canonical Wnt signaling pathwayGO:006007010.0MYH6, NKX2-5, GATA4
17atrial septum morphogenesisGO:006041310.0NKX2-5, TBX20, GATA4
18response to estrogenGO:004362710.0CITED2, GATA6, GATA4
19outflow tract septum morphogenesisGO:000314810.0NKX2-5, TBX20, GATA6
20cardiac muscle tissue morphogenesisGO:005500810.0ACTC1, NKX2-5, TBX20
21positive regulation of cardiac muscle cell proliferationGO:006004510.0GATA4, GATA6, TBX20
22male gonad developmentGO:000858410.0GATA4, GATA6, CITED2
23spleen developmentGO:00485369.9CITED2, NKX2-5
24thyroid gland developmentGO:00308789.9NKX2-5, NKX2-1
25positive regulation of blood coagulationGO:00301949.9APOH, F12
26endoderm developmentGO:00074929.8NKX2-1, GATA4
27muscle filament slidingGO:00300499.8ACTC1, MYH6
28blood coagulation, intrinsic pathwayGO:00075979.8APOH, F12
29in utero embryonic developmentGO:00017019.7GATA4, GATA6, MYH6
30heart loopingGO:00019479.7CITED2, NKX2-5, TBX20, GATA4
31cardiac muscle contractionGO:00600489.7NKX2-5, ACTC1
32blood circulationGO:00080159.6F5, TBX20
33negative regulation of apoptotic processGO:00430669.6GATA6, NKX2-5, ACTC1, CITED2
34negative regulation of transcription, DNA-templatedGO:00458929.6CITED2, NKX2-5, TBX20, GATA6
35positive regulation of transcription, DNA-templatedGO:00458939.4CITED2, NKX2-5, NKX2-1, GATA4
36negative regulation of transcription from RNA polymerase II promoterGO:00001229.1CITED2, NKX2-5, NKX2-1, TBX20, GATA6
37positive regulation of transcription from RNA polymerase II promoterGO:00459448.9CITED2, NKX2-5, NKX2-1, TBX20, GATA6, GATA4
38blood coagulationGO:00075968.7F12, F5, GATA6, GATA4, FGA

Molecular functions related to Patent Foramen Ovale according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription coactivator activityGO:00011059.8TBX20, CITED2
2RNA polymerase II regulatory region sequence-specific DNA bindingGO:00009779.7TBX20, GATA4
3transcription factor bindingGO:00081349.7GATA4, GATA6, NKX2-5
4chromatin bindingGO:00036829.5CITED2, NKX2-5, GATA6, GATA4
5RNA polymerase II activating transcription factor bindingGO:00011029.5TBX20, CITED2
6RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:00037059.4GATA4, GATA6, NKX2-1, NKX2-5
7transcription regulatory region DNA bindingGO:00442129.4NKX2-5, NKX2-1, GATA6, GATA4
8sequence-specific DNA binding transcription factor activityGO:00037008.6CITED2, NKX2-5, NKX2-1, TBX20, GATA6, GATA4
9protein bindingGO:00055156.7F12, APOH, CITED2, NKX2-5, NKX2-1, F5

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Sources for Patent Foramen Ovale

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet