MCID: PTH002
MIFTS: 58

Pathological Gambling malady

Neuronal diseases category

Summaries for Pathological Gambling

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Many people enjoy gambling, whether it's betting on a horse or playing poker on the internet. most people who gamble don't have a problem, but some lose control of their gambling. signs of problem gambling include always thinking about gambling lying about gambling spending work or family time gambling feeling bad after you gamble, but not quitting gambling with money you need for other things if you have concerns about your gambling, ask for help. your health care provider can work with you to find the treatment that's best for you. nih: natonal institutes of health

MalaCards: Pathological Gambling, also known as compulsive gambling, is related to parkinson's disease and personality disorder. An important gene associated with Pathological Gambling is DRD4 (dopamine receptor D4), and among its related pathways are phenylalanine utilization and melatonin degradation II. The compounds eticlopride and rotigotine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and subthalamic nucleus, and related mouse phenotypes are cardiovascular system and normal.

Disease Ontology:8 An impulse control disorder that involves the uncontrollable impulse to gamble, irrespective of the interference the behaviour has on the individual's life.

Wikipedia:63 Problem gambling, or ludomania, is an urge to continuously gamble despite harmful negative consequences... more...

Description from OMIM:46 606349

Aliases & Classifications for Pathological Gambling

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8Disease Ontology, 10DISEASES, 33MedlinePlus, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 46OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

pathological gambling 8 10
compulsive gambling 8 33
gambling, pathological 60


External Ids:

Disease Ontology8 DOID:12399
ICD9CM27 312.31
MeSH34 D005715
OMIM46 606349
ICD1025 F63.0

Related Diseases for Pathological Gambling

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pathological Gambling via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson's disease31.2DRD1, HTR2A, DRD2, DRD3, DRD4, SLC6A3
2personality disorder30.8DRD2, DRD3, MAOB, MAOA, SLC6A3, DRD4
3obsessive-compulsive disorder30.8DRD3, DRD4, MAOA, SLC6A3, SLC6A4, DRD2
4alcohol dependence30.6DRD4, SLC6A4, DRD1, MAOA, DRD2, HTR2A
5schizophrenia30.5DRD3, HTR2A
6restless legs syndrome30.4DRD2
7substance abuse30.4DRD2, DRD3, DRD4, SLC6A3, SLC6A4
8dementia30.4MAOA, HTR2A, SLC6A3, MAOB
9eating disorder30.4HTR2A, SLC6A3, SLC6A4
10mood disorder30.3DBH, MAOB, MAOA, SLC6A4, SLC6A3, GRIN1
11obsessive-compulsive personality disorder30.3SLC6A4
12nicotine dependence30.3DRD2, DRD4, SLC6A4
13bulimia nervosa30.3SLC6A4, MAOA, HTR2A
14alcohol abuse30.3DRD2, DRD3, SLC6A3, SLC6A4
15antisocial personality disorder30.2SLC6A3, HTR2A, MAOA, DRD2, SLC6A4
16anxiety disorder30.2HTR2A, MAOB, DRD2, SLC6A3, MAOA, SLC6A4
17amyotrophic lateral sclerosis30.0SLC6A3, MAOB, RTN4
18bipolar disorder30.0HTR2A, MAOA, SLC6A4
19schizoaffective disorder30.0SLC6A4, DRD4, DRD2, HTR2A, DRD3
20substance dependence30.0SLC6A3, SLC6A4, DRD5, DRD3, DRD2, DRD4
21obesity30.0DRD2, SLC6A3, MAOB, MAOA, DRD4, HTR2A
22cocaine dependence30.0DRD2, DRD3, DBH, SLC6A3, SLC6A4
23frontotemporal dementia10.3
24impulse control disorder10.3
25prolactinoma10.2
26alexithymia10.2
27body dysmorphic disorder10.2
28kleptomania10.2
29pyromania10.2
30lateral sclerosis10.0
31multiple sclerosis10.0
32sexual disorder10.0
33withdrawal disorder10.0
34blindness10.0MAOB
35myoclonus-dystonia10.0DRD2
36huntington's disease10.0DRD2
37heroin dependence10.0DRD4, DRD2
38alcoholic psychosis10.0SLC6A4
39delusional disorder10.0DRD2, DRD4
40melancholia10.0MAOA
41attention deficit hyperactivity disorder10.0DRD4, SLC6A3
42striatonigral degeneration10.0SLC6A3, DRD2
43wilson disease10.0SLC6A3, DRD2
44borderline personality disorder10.0MAOA, SLC6A4
45opiate dependence10.0DRD3, DRD2
46hepatic encephalopathy10.0MAOB, MAOA
47focal dystonia10.0DRD2, DRD5
48chronic fatigue syndrome10.0MAOA, SLC6A4
49endogenous depression10.0SLC6A4, DRD3
50neuroblastoma10.0DBH

Graphical network of the top 20 diseases related to Pathological Gambling:



Diseases related to pathological gambling

Clinical Features for Pathological Gambling

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Sources:
46OMIM
See all sources

Clinical features from OMIM:

606349

Drugs & Therapeutics for Pathological Gambling

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Pathological Gambling

Drug clinical trials:

Search ClinicalTrials for Pathological Gambling

Search NIH Clinical Center for Pathological Gambling

Search CenterWatch for Pathological Gambling

Genetic Tests for Pathological Gambling

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Anatomical Context for Pathological Gambling

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Sources:
32MalaCards
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MalaCards organs/tissues related to Pathological Gambling:

32
Brain, Cortex, Subthalamic nucleus, Testes, Prefrontal cortex, Skin, Heart, Pituitary

Animal Models for Pathological Gambling or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pathological Gambling:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.2SLC6A4, DRD5, DBH, MAOA, GRIN1, DRD3
2MP:00028737.8DRD5, GRIN1, DBH, RTN4, SLC6A3, SLC6A4
3MP:00053767.7DRD2, SLC6A3, MAOB, DBH, MAOA, SLC6A4
4MP:00053797.7SLC6A4, SLC6A3, DBH, DRD5, DRD2, HTR2A
5MP:00053866.4EPHB2, DBH, DNER, MAOB, MAOA, GRIN1
6MP:00107686.0ALDH18A1, DRD1, PPP4C, SLC6A4, SLC6A3, RTN4
7MP:00036315.9DRD1, EPHB2, SLC6A4, SLC6A3, RTN4, DBH

Publications for Pathological Gambling

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Sources:
50PubMed
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Articles related to Pathological Gambling:

(show top 50)    (show all 498)
idTitleAuthorsYear
1
Pharmacological treatments in pathological gambling. (22979951)
2014
2
How central is dopamine to pathological gambling or gambling disorder? (24391562)
2013
3
Deep transcranial magnetic stimulation for the treatment of pathological gambling. (23078873)
2013
4
Monthly injectable naltrexone for pathological gambling. (23732971)
2013
5
Pathological Gambling, Co-occurring Disorders, Clinical Presentation, and Treatment Outcomes at a University-Based Counseling Clinic. (23297170)
2013
6
Seeking safety therapy for pathological gambling and PTSD: a pilot outcome study. (23662327)
2013
7
Egocentric social network analysis of pathological gambling. (23072641)
2013
8
The Genetics of Problem and Pathological Gambling: A Systematic Review. (24001288)
2013
9
Imbalance in the sensitivity to different types of rewards in pathological gambling. (23757765)
2013
10
Should pathological gambling be considered an addictive disorder? (22981047)
2012
11
Mesolimbic dopamine release is linked to symptom severity in pathological gambling. (22348881)
2012
12
Compulsive features in behavioural addictions: the case of pathological gambling. (21985690)
2012
13
Pathological gambling: a systematic review of biochemical, neuroimaging, and neuropsychological findings. (22716504)
2012
14
Personality disorders and dimensions in pathological gambling. (22686226)
2012
15
Striatal dopamine release codes uncertainty in pathological gambling. (22889563)
2012
16
Eating disorders and pathological gambling in males: can they be differentiated by means of weight history and temperament and character traits? (22985236)
2012
17
Gender-related clinical and neurocognitive differences in individuals seeking treatment for pathological gambling. (22726595)
2012
18
Pathological gambling: a general overview. (22641963)
2012
19
Acamprosate and Baclofen were Not Effective in the Treatment of Pathological Gambling: Preliminary Blind Rater Comparison Study. (21713109)
2011
20
Dopamine release in ventral striatum during Iowa Gambling Task performance is associated with increased excitement levels in pathological gambling. (20883460)
2011
21
Pathological gambling and the structure of common mental disorders. (22134454)
2011
22
Treatment of pathological gambling with disulfiram: a report of 2 cases. (21328196)
2011
23
Psychopharmacological treatment in pathological gambling: a critical review. (21524264)
2011
24
Hypersexuality and pathological gambling in Parkinson's disease: A cross-sectional case-control study. (21735482)
2011
25
Nalmefene in the treatment of pathological gambling: multicentre, double-blind, placebo-controlled study. (20884959)
2010
26
Pathological gambling: relation of skin conductance response to dopaminergic neurotransmission and sensation-seeking. (20813510)
2010
27
Pathological gambling: influence of quality of life and psychological distress on abstinence after cognitive-behavioral inpatient treatment. (19357936)
2009
28
Treatment of pathological gambling. (19122538)
2009
29
Dopamine agonists diminish value sensitivity of the orbitofrontal cortex: a trigger for pathological gambling in Parkinson's disease? (19741594)
2009
30
Pathological gambling subtypes. (19947793)
2009
31
Imaginal desensitisation plus motivational interviewing for pathological gambling: randomised controlled trial. (19721120)
2009
32
A preliminary investigation of abstinence and controlled gambling as self-selected goals of treatment for female pathological gambling. (19199009)
2009
33
Relationship of nicotine dependence, subsyndromal and pathological gambling, and other psychiatric disorders: data from the National Epidemiologic Survey on Alcohol and Related Conditions. (19254518)
2009
34
Parallel roles for dopamine in pathological gambling and psychostimulant addiction. (19630734)
2009
35
Increased striatal dopamine release in Parkinsonian patients with pathological gambling: a [11C] raclopride PET study. (19346328)
2009
36
A Canadian population level analysis of the roles of irrational gambling cognitions and risky gambling practices as correlates of gambling intensity and pathological gambling. (18256906)
2008
37
Course of pathological gambling symptoms and reliability of the Lifetime Gambling History measure. (17367870)
2007
38
Impulsivity and compulsivity in pathological gambling and obsessive-compulsive disorder. (17639252)
2007
39
Using STN DBS and medication reduction as a strategy to treat pathological gambling in Parkinson's disease. (17049455)
2007
40
Bupropion therapy for pathological gambling. (17341539)
2007
41
Pharmacotherapy of pathological gambling: review of new treatment modalities. (17181431)
2006
42
Relationship between pathological gambling, alcoholism and drug addiction. (16649512)
2006
43
Remission from pathological gambling among Hispanics and Native Americans. (16897410)
2006
44
The association between comorbidity and outcome in pathological gambling: a prospective follow-up of recent quitters. (16134008)
2005
45
Quality of life and family history in pathological gambling. (12586967)
2003
46
Gambling urges in pathological gambling: a functional magnetic resonance imaging study. (12912766)
2003
47
Schizophrenia and pathological gambling. (11229999)
2001
48
The additive effect of neurotransmitter genes in pathological gambling. (11553044)
2001
49
WITHDRAWN: Interventions for pathological gambling. (17636678)
2000
50
Criminal Behavior Associated with Pathological Gambling. (12766453)
1999

Genetic Variations for Pathological Gambling

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Expression for genes affiliated with Pathological Gambling

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pathological Gambling

Search GEO for disease gene expression data for Pathological Gambling.

Pathways for genes affiliated with Pathological Gambling

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Sources:
37NCBI BioSystems Database, 53Reactome, 29KEGG, 49PharmGKB, 12EMD Millipore, 51QIAGEN
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Pathways related to Pathological Gambling according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0MAOB, MAOA
2
Hide members
10.0MAOA, MAOB
3
Hide members
9.9SLC6A3, MAOA
4
Hide members
9.7MAOA, MAOB, ALDH18A1
5
Hide members
9.6DRD1, DRD2, DRD3, DRD4
69.6DRD4, DRD3, HTR2A
79.6DRD1, DRD2, DRD4, GRIN1
8
Hide members
9.5MAOA, MAOB, DBH
9
Tyrosine metabolism p.1 (dopamine)
Hide members
9.5DBH, MAOB, MAOA
10
Hide members
9.4DRD1, DRD2, DRD3, DRD4, DRD5
119.4DRD1, DRD2, DRD3, DRD4, DRD5
129.3DBH, SLC6A3, SLC6A4
139.3GRIN1, DRD5, DRD1, HTR2A
149.2DRD1, DRD2, DRD3, DRD4, DRD5, GRIN1
159.1HTR2A, GRIN1, MAOA, SLC6A4
16
Hide members
8.9DRD1, DRD2, GRIN1, MAOA, MAOB, SLC6A3
178.9DRD1, DRD2, GRIN1, MAOA, MAOB, SLC6A3
18
Hide members
8.6HTR2A, DRD1, DRD2, DRD3, DRD4, DRD5
19
Hide members
8.3SLC6A4, HTR2A, DRD1, DRD2, DRD3, DRD4
20
Hide members
7.6HTR2A, DRD1, DRD2, DRD3, DRD4, DRD5
21
Hide members
7.4HTR2A, DRD1, DRD2, DRD3, DRD4, DRD5

Compounds for genes affiliated with Pathological Gambling

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Sources:
28IUPHAR, 44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Pathological Gambling according to GeneCards/GeneDecks:

(show top 50)    (show all 276)
idCompoundScoreTop Affiliating Genes
1eticlopride28 4410.6DRD4, DRD3, DRD2, DRD1
2rotigotine44 28 1111.6DRD4, DRD3, DRD2, DRD1, MAOB, DRD5
3fluphenazine28 44 1111.4HTR2A, DRD1, DRD2, DRD5, DRD4
4(+)-butaclamol28 4410.4DRD1, DRD2, DRD3, DRD4, DRD5, HTR2A
5dopac449.3DRD1, DRD3, MAOA, MAOB, DBH
6spiperone28 4410.3DRD5, DRD4, DRD3, DRD2, DRD1, HTR2A
7lisuride28 44 1111.3DRD3, DRD5, HTR2A, DRD4, DRD2, DRD1
8pergolide28 44 1111.3HTR2A, DRD1, DRD2, DRD3, DRD4, DRD5
9Methotrimeprazine119.3DRD5, DRD4, HTR2A, DRD1, DRD2, DRD3
10d amphetamine449.3DRD1, DRD2, MAOA, MAOB, SLC6A3, SLC6A4
11cabergoline28 44 1111.2DRD5, DRD4, HTR2A, DRD2, DRD1, DRD3
12sulpiride44 28 1111.2DRD4, DRD2, DRD1, SLC6A3, DRD3
13aripiprazole28 49 44 11 2413.2HTR2A, DRD1, DRD2, DRD3, DRD4, DRD5
14nmda44 2810.2EPHB2, SLC6A3, MAOA, GRIN1, MAOB
15piperazine44 1110.2DRD4, SLC6A3, HTR2A, DRD3, DRD2
16raclopride44 2810.2SLC6A3, DRD4, DRD2, DRD1, DRD3, HTR2A
17ziprasidone49 28 44 1112.2DRD5, DRD4, HTR2A, DRD1, DRD2, DRD3
18minaprine44 1110.2HTR2A, DRD1, SLC6A4, MAOA, DRD2
19quinpirole44 2810.2DRD2, SLC6A3, DRD4, HTR2A, DRD1, DRD3
20mhpg449.1DRD4, DBH, MAOA, SLC6A4, MAOB
21ropinirole44 1110.1DRD5, MAOB, DRD4, DRD3, HTR2A, DRD1
22MMDA119.1MAOB, HTR2A, SLC6A3, SLC6A4, MAOA
23pramipexole44 49 28 1112.0HTR2A, DRD1, DRD2, DRD3, DRD4, DRD5
24amphetamine44 1110.0DRD1, DRD4, MAOA, MAOB, SLC6A3, SLC6A4
25quetiapine44 49 28 11 2413.0DRD5, HTR2A, SLC6A3, DRD1, DRD2, DRD3
26chlorpromazine44 28 49 1112.0DRD3, DRD2, DRD4, HTR2A, DRD5, DRD1
27bromocriptine28 44 1111.0DRD2, DRD4, DRD5, DRD1, HTR2A, SLC6A3
28olanzapine49 44 28 11 2412.9HTR2A, SLC6A3, DRD5, DRD4, DRD3, DRD2
29paroxetine44 49 28 1111.9SLC6A4, SLC6A3, MAOA, DRD4, HTR2A, DRD3
30catecholamine448.9DBH, DRD1, DRD5, MAOA, MAOB, DRD4
31methamphetamine44 49 1110.9SLC6A4, DRD1, DRD2, DRD3, DRD4, MAOA
32methylphenidate44 49 1110.9MAOB, SLC6A3, SLC6A4, MAOA, DRD5, DRD1
336-hydroxydopamine448.8DRD4, DRD1, DRD2, DRD3, MAOA, DBH
34trimipramine49 44 1110.8SLC6A4, HTR2A, DRD1, DRD2, SLC6A3
35risperidone28 44 49 59 11 2413.8DRD4, DRD3, DRD2, DRD1, SLC6A3, HTR2A
36apomorphine44 28 1110.8SLC6A3, MAOB, DRD5, HTR2A, DRD1, DRD2
37clozapine44 28 49 1111.6SLC6A4, SLC6A3, DRD5, DRD4, DRD3, DRD2
38levodopa44 119.6DRD5, MAOA, MAOB, DBH, SLC6A3, DRD4
39haloperidol44 28 2 49 1112.4HTR2A, DRD1, DRD2, DRD3, DRD4, DRD5
40cocaine44 119.3SLC6A4, DBH, SLC6A3, MAOB, GRIN1, DRD1
41maoa448.3DRD2, DRD4, MAOA, MAOB, DBH, SLC6A3
42mptp448.3SLC6A4, SLC6A3, DBH, MAOA, GRIN1, DRD3
43imipramine44 49 28 11 2412.3SLC6A3, SLC6A4, HTR2A, DRD1, MAOA, MAOB
44gaba448.2DBH, MAOB, GRIN1, DRD1, DRD4, DRD2
45fluoxetine49 44 28 1111.2DRD2, HTR2A, SLC6A3, MAOA, MAOB, SLC6A4
465-hydroxytryptamine448.2DRD2, DBH, HTR2A, MAOA, MAOB, DRD4
47nicotine44 49 28 1111.1SLC6A4, SLC6A3, DRD4, GRIN1, MAOA, MAOB
48glutamate447.5DBH, DRD4, GRIN1, MAOA, MAOB, ALDH18A1
49norepinephrine44 11 249.4DRD3, DRD5, DRD4, GRIN1, MAOA, DRD2
50dopamine44 28 11 2410.4HTR2A, DRD1, DRD2, DRD3, DRD4, DBH

GO Terms for genes affiliated with Pathological Gambling

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16Gene Ontology
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Cellular components related to Pathological Gambling according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendritic spineGO:0431979.8GRIN1, DRD4, DRD2
2axonGO:0304248.9HTR2A, DRD2, EPHB2, SLC6A3
3dendriteGO:0304258.7EPHB2, DNER, GRIN1, DRD2
4neuronal cell bodyGO:0430258.2DRD4, DNER, EPHB2, RTN4, SLC6A3
5integral to plasma membraneGO:0058877.6SLC6A4, HTR2A, DRD1, DRD2, DRD3, DRD4
6plasma membraneGO:0058865.8DRD4, DRD3, DRD2, DRD1, HTR2A, DRD5

Biological processes related to Pathological Gambling according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idNameGO IDScoreTop Affiliating Genes
1sensitizationGO:04696010.4DRD1, DRD5
2negative regulation of voltage-gated calcium channel activityGO:190138610.4DRD2, DRD4
3negative regulation of dopamine receptor signaling pathwayGO:06016010.4DRD2, DRD3
4positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.4DRD2, DRD4
5olfactory learningGO:00835510.3DRD4, GRIN1
6regulation of cAMP metabolic processGO:03081410.3DRD2, DRD3
7cellular response to catecholamine stimulusGO:07187010.3DRD1, DRD5
8response to histamineGO:03477610.3DRD4, DRD3, DRD2
9adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.3DRD4, DRD3, DRD2
10adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.3DRD1, DRD3, DRD5
11regulation of dopamine uptake involved in synaptic transmissionGO:05158410.3DRD1, DRD2, DRD3
12cerebral cortex GABAergic interneuron migrationGO:02185310.2DRD1, DRD2
13negative regulation of protein secretionGO:05070910.2DRD4, DRD3, DRD2
14arachidonic acid secretionGO:05048210.2DRD2, DRD3, DRD4
15conditioned taste aversionGO:00166110.2DRD1, GRIN1
16phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.2DRD1, DRD2, DRD5
17dopamine transportGO:01587210.2DRD1, SLC6A3
18positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayGO:01057910.2DRD1, DRD5
19negative regulation of adenylate cyclase activityGO:00719410.2DRD2, DRD3, DRD4
20negative regulation of blood pressureGO:04577610.2DRD5, DRD3, DRD2
21regulation of dopamine metabolic processGO:04205310.2DRD1, DRD4, SLC6A3
22fear responseGO:04259610.1DBH, DRD4
23response to morphineGO:04327810.1GRIN1, DRD3, DRD2
24adenohypophysis developmentGO:02198410.1DRD2, SLC6A3
25peristalsisGO:03043210.1DRD1, DRD2
26dopamine metabolic processGO:04241710.1DRD4, DRD3, DRD2, DRD1
27behavioral response to cocaineGO:04814810.1DRD4, DRD3, DRD2, DRD1
28behavioral response to ethanolGO:04814910.0DRD2, DRD4, DBH
29monoamine transportGO:01584410.0SLC6A3, SLC6A4
30long term synaptic depressionGO:06029210.0DRD5, DRD1
31response to cocaineGO:0422209.9DRD2, DRD3, DRD5, SLC6A3
32regulation of dopamine secretionGO:0140599.9HTR2A, DRD2, DRD3
33response to iron ionGO:0100399.9SLC6A3, DRD2
34dopamine catabolic processGO:0424209.9MAOA, DBH, SLC6A3
35synaptic transmission, dopaminergicGO:0019639.9DRD1, DRD2, DRD3, DRD4, DRD5
36temperature homeostasisGO:0016599.9HTR2A, DRD1, DRD2
37social behaviorGO:0351769.9DRD3, DRD4, GRIN1, SLC6A4
38synapse assemblyGO:0074169.8DRD1, DRD2, DNER
39response to ethanolGO:0454719.8SLC6A3, MAOB, GRIN1, DRD3
40G-protein coupled receptor internalizationGO:0020319.7DRD3, DRD2
41negative regulation of synaptic transmission, glutamatergicGO:0519679.7DRD2, HTR2A
42response to toxic substanceGO:0096369.7SLC6A4, MAOB, DRD2
43prepulse inhibitionGO:0601349.7DRD1, DRD2, DRD3, GRIN1, SLC6A3
44locomotory behaviorGO:0076269.6SLC6A3, DBH, DRD3, DRD2
45visual learningGO:0085429.5DRD1, DRD2, DRD3, GRIN1, DBH
46memoryGO:0076139.3HTR2A, DRD1, DBH, SLC6A4
47cellular calcium ion homeostasisGO:0068749.3HTR2A, DRD2, DRD3, DRD4, DRD5, GRIN1
48response to amphetamineGO:0019759.2DBH, GRIN1, DRD5, DRD4, DRD3, DRD2
49synaptic transmissionGO:0072688.8HTR2A, DRD5, GRIN1, MAOA, DBH, SLC6A3
50response to drugGO:0424938.8HTR2A, DRD1, DRD2, DRD3, MAOB, SLC6A3

Molecular functions related to Pathological Gambling according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activity, coupled via GsGO:00158810.1DRD1, DRD5
2primary amine oxidase activityGO:00813110.0MAOB, MAOA
3dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.0DRD4, DRD3, DRD2
4dopamine neurotransmitter receptor activityGO:0049529.9DRD5, DRD4, DRD1
5monoamine transmembrane transporter activityGO:0085049.5SLC6A4, SLC6A3
6dopamine bindingGO:0352409.3SLC6A3, DRD5, DRD4, DRD3, DRD2, DRD1
7drug bindingGO:0081449.2HTR2A, DRD2, DRD3, DRD4, SLC6A3
8protein bindingGO:0055155.4DRD1, DRD2, DRD3, DRD4, PPP4C, GRIN1

Products for genes affiliated with Pathological Gambling

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pathological Gambling

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet