MCID: PTH002
MIFTS: 60

Pathological Gambling malady

Mental diseases category
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Summaries for Pathological Gambling

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MedlinePlus:33 Many people enjoy gambling, whether it's betting on a horse or playing poker on the internet. most people who gamble don't have a problem, but some lose control of their gambling. signs of problem gambling include always thinking about gambling lying about gambling spending work or family time gambling feeling bad after you gamble, but not quitting gambling with money you need for other things if you have concerns about your gambling, ask for help. your health care provider can work with you to find the treatment that's best for you. nih: national institutes of health

MalaCards based summary: Pathological Gambling, also known as compulsive gambling, is related to schizophrenia and anxiety disorder. An important gene associated with Pathological Gambling is DRD5 (dopamine receptor D5), and among its related pathways are Biogenic Amine Synthesis and Dopamine metabolism. The compounds cis flupentixol and fluphenazine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and subthalamic nucleus, and related mouse phenotypes are adipose tissue and vision/eye.

Disease Ontology:8 An impulse control disorder that involves the uncontrollable impulse to gamble, irrespective of the interference the behaviour has on the individual's life.

Wikipedia:65 Problem gambling (or ludomania, but usually referred to as gambling addiction) is an urge to... more...

Description from OMIM:46 606349

Aliases & Classifications for Pathological Gambling

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Pathological Gambling, Aliases & Descriptions:

Name: Pathological Gambling 8 10
Compulsive Gambling 8 33
 
Gambling, Pathological 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:12399
ICD9CM27 312.31
MeSH34 D005715
OMIM46 606349
ICD1025 F63.0

Related Diseases for Pathological Gambling

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Diseases related to Pathological Gambling via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia31.0DRD3, HTR2A
2anxiety disorder30.8SLC6A4, MAOA
3nicotine dependence30.6DRD4, DRD2, SLC6A4
4parkinson's disease30.6DBH, MAOA, MAOB, SLC6A3, DRD3, DRD2
5bulimia nervosa30.4HTR2A, SLC6A4, MAOA
6drug addiction30.3DRD2, SLC6A3, DRD1, DRD3
7eating disorder30.3SLC6A3, SLC6A4, HTR2A
8bipolar disorder30.2SLC6A4, HTR2A, MAOA
9dementia30.1HTR2A, MAOB, MAOA, SLC6A3
10alcohol abuse30.1SLC6A4, DRD2, DRD3, SLC6A3
11substance abuse30.0SLC6A3, DRD4, SLC6A4, DRD2, DRD3
12alcohol dependence30.0HTR2A, MAOA, DRD4, DRD2, DRD1, SLC6A4
13schizoaffective disorder29.9DRD2, SLC6A4, DRD3, DRD4, HTR2A
14personality disorder29.8MAOA, MAOB, DRD4, DRD3, DRD2, SLC6A4
15antisocial personality disorder29.7DRD2, SLC6A4, SLC6A3, MAOA, HTR2A
16obsessive-compulsive disorder29.7DRD1, MAOA, HTR2A, DRD4, DRD3, SLC6A3
17cocaine dependence29.6DBH, SLC6A4, DRD3, DRD2, SLC6A3
18substance dependence29.5DRD5, DRD3, DRD2, SLC6A4, SLC6A3, DRD4
19obesity29.3SLC6A3, HTR2A, MAOA, MAOB, DRD4, DRD2
20mood disorder28.7DBH, HTR2A, MAOA, MAOB, DRD4, DRD3
21blindness10.6
22melancholia10.5MAOA
23alcoholic psychosis10.4SLC6A4
24neuroleptic malignant syndrome10.4DRD2
25obsessive-compulsive personality disorder10.4SLC6A4
26delusional disorder10.4DRD4, DRD2
27premature ejaculation10.4SLC6A4
28frontotemporal dementia10.3
29restless legs syndrome10.3
30impulse control disorder10.3
31heroin dependence10.3DRD2, DRD4
32opiate dependence10.3DRD2, DRD3
33focal dystonia10.3DRD5, DRD2
34serotonin syndrome10.3MAOA, HTR2A
35endogenous depression10.3SLC6A4, DRD3
36dysthymic disorder10.3MAOA, HTR2A
37body dysmorphic disorder10.2
38alexithymia10.2
39borderline personality disorder10.2SLC6A4, MAOA
40oppositional defiant disorder10.2SLC6A3, DRD4
41hepatic encephalopathy10.2MAOA, MAOB
42hyperprolactinemia10.2DRD2, DBH, DRD4
43attention deficit hyperactivity disorder10.2SLC6A3, DRD4
44portal hypertension10.2HTR2A, MAOA
45striatonigral degeneration10.1DRD2, SLC6A3
46chronic fatigue syndrome10.1SLC6A4, MAOA
47narcolepsy10.1HTR2A, DRD1, DRD2
48pure autonomic failure10.1MAOB, DBH, MAOA
49social phobia10.1SLC6A4, DRD2, MAOA
50fibromyalgia10.1HTR2A, SLC6A4

Graphical network of the top 20 diseases related to Pathological Gambling:



Diseases related to pathological gambling

Symptoms for Pathological Gambling

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Clinical features from OMIM:

606349

Drugs & Therapeutics for Pathological Gambling

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Drug clinical trials:

Search ClinicalTrials for Pathological Gambling

Search NIH Clinical Center for Pathological Gambling

Genetic Tests for Pathological Gambling

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Anatomical Context for Pathological Gambling

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MalaCards organs/tissues related to Pathological Gambling:

32
Brain, Cortex, Subthalamic nucleus, Testes, Prefrontal cortex, Heart, Skin, Pituitary

Animal Models for Pathological Gambling or affiliated genes

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MGI Mouse Phenotypes related to Pathological Gambling:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.8DBH, DRD3, DRD2, DRD1
2MP:00053918.6DBH, ALDH18A1, DRD4, DRD5, DRD1
3MP:00053858.1DBH, MAOA, DRD5, DRD3, DRD2, DRD1
4MP:00107718.1SLC6A3, SLC6A4, DRD1, DRD2, DBH
5MP:00053697.9HTR2A, DRD2, DRD1, SLC6A4, SLC6A3
6MP:00053797.6DBH, HTR2A, DRD5, DRD2, SLC6A4, SLC6A3
7MP:00053766.8DBH, MAOA, MAOB, DRD4, DRD3, DRD2
8MP:00036316.6DBH, MAOA, MAOB, DRD4, DRD5, DRD3
9MP:00053866.4SLC6A3, DBH, HTR2A, MAOA, MAOB, DRD4

Publications for Pathological Gambling

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Articles related to Pathological Gambling:

(show top 50)    (show all 510)
idTitleAuthorsYear
1
Reward-based decision making in pathological gambling: The roles of risk and delay. (25269860)
2014
2
Differences between early-onset pathological gambling and later-onset pathological gambling: data from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). (25006638)
2014
3
Bet on sleep for the understanding of pathological gambling. (25005740)
2014
4
Waking self-hypnosis efficacy in cognitive-behavioral treatment for pathological gambling: an effectiveness clinical assay. (24256479)
2014
5
Neuronal and psychological underpinnings of pathological gambling. (25071487)
2014
6
Cross-species approaches to pathological gambling: A review targeting sex differences, adolescent vulnerability and ecological validity of research tools. (23867802)
2013
7
How central is dopamine to pathological gambling or gambling disorder? (24391562)
2013
8
Pathological gambling in x-linked dystonia parkinsonism. (23629417)
2013
9
The Impulsivity and Sensation-Seeking Mediators of the Psychological Consequences of Pathological Gambling in Adolescence. (24297606)
2013
10
Pathological gambling in Parkinson's disease: subthalamic oscillations during economics decisions. (23554027)
2013
11
Commentary on Petry eta88al. (2013): Actus Reus--why it matters to pathological gambling treatment. (23418660)
2013
12
Pathological gambling in eating disorders: prevalence and clinical implications. (23759149)
2013
13
The relationship between universal human values and adolescent problem and pathological gambling. (22540439)
2012
14
Telescoping phenomenon in pathological gambling: association with gender and comorbidities. (23124186)
2012
15
Should pathological gambling be considered an addictive disorder? (22981047)
2012
16
Cognitive-behavioral therapy for pathological gambling in Parkinson's disease: a pilot controlled study. (22760081)
2012
17
Acamprosate and Baclofen were Not Effective in the Treatment of Pathological Gambling: Preliminary Blind Rater Comparison Study. (21713109)
2011
18
Dopamine release in ventral striatum during Iowa Gambling Task performance is associated with increased excitement levels in pathological gambling. (20883460)
2011
19
To gamble or not to gamble: at risk for craving and relapse--learned motivated attention in pathological gambling. (21453747)
2011
20
The prevalence and course of pathological gambling in the mood disorders. (20502951)
2011
21
The relationship of pathological gambling to criminality behavior in a sample of Polish male offenders. (22037748)
2011
22
Problem and pathological gambling in a sample of casino patrons. (20549549)
2011
23
A 6-month follow-up of imaginal desensitization plus motivational interviewing in the treatment of pathological gambling. (21318190)
2011
24
Pathological gambling: an impulse control disorder? Measurement of impulsivity using neurocognitive tests. (20803888)
2010
25
Cognitive status of patients with Parkinson's disease and pathological gambling. (19727901)
2010
26
Noradrenergic function in pathological gambling: blunted growth hormone response to clonidine. (19028836)
2010
27
Pathological gambling: influence of quality of life and psychological distress on abstinence after cognitive-behavioral inpatient treatment. (19357936)
2009
28
Is control a viable goal in the treatment of pathological gambling? (19118818)
2009
29
A randomized, double-blind, placebo-controlled trial of naltrexone in the treatment of concurrent alcohol use disorder and pathological gambling. (19340640)
2009
30
Comorbidity in pathological gambling: clinical variables, personality and treatment response. (23034347)
2009
31
Alexithymia and pathological gambling. (20155587)
2009
32
Pathological gambling and Parkinson disease]. (18807938)
2008
33
A double-blind, placebo-controlled study of the opiate antagonist naltrexone in the treatment of pathological gambling urges. (18384246)
2008
34
Pathological gambling after bilateral subthalamic nucleus stimulation in Parkinson disease. (17210626)
2007
35
Schizophrenia and pathological gambling. (17661194)
2007
36
Treatment of juvenile Parkinson disease and the recurrent emergence of pathologic gambling. (17356338)
2007
37
Pathological gambling. (16466112)
2006
38
A family study of pathological gambling. (16499975)
2006
39
Neuropsychological performance, impulsivity, and comorbid psychiatric illness in patients with pathological gambling undergoing treatment at the CORE Inpatient Treatment Center. (16466120)
2006
40
Prevalence and diagnostic correlates of DSM-IV pathological gambling in psychiatric outpatients. (16816991)
2006
41
Should the scope of addictive behaviors be broadened to include pathological gambling? (16930172)
2006
42
Update on pathological gambling. (16513043)
2006
43
Sustained-release bupropion versus naltrexone in the treatment of pathological gambling: a preliminary blind-rater study. (16282845)
2005
44
Outcome of psychological treatments of pathological gambling: a review and meta-analysis. (16185203)
2005
45
The vulnerable faces of pathological gambling. (21179650)
2005
46
Recent research on the comorbidity of alcoholism and pathological gambling. (12605078)
2003
47
Nefazodone treatment of pathological gambling: a prospective open-label controlled trial. (12444818)
2002
48
Drugs can trigger pathological gambling. (11985369)
2002
49
Pathological gambling: a current perspective. (11447566)
2001
50
WITHDRAWN: Interventions for pathological gambling. (17636678)
2000

Variations for Pathological Gambling

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Expression for genes affiliated with Pathological Gambling

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Expression patterns in normal tissues for genes affiliated with Pathological Gambling

Search GEO for disease gene expression data for Pathological Gambling.

Pathways for genes affiliated with Pathological Gambling

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Pathways related to Pathological Gambling according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
catecholamine biosynthesis37
9.7MAOA, DBH
29.7MAOA, MAOB
3
Show member pathways
histamine biosynthesis37
9.7MAOA, MAOB
4
Show member pathways
choline degradation I37
glycine biosynthesis III37
serine and glycine biosynthesis37
glycine betaine degradation37
glycine biosynthesis37
9.7MAOB, MAOA
59.7MAOB, MAOA
69.7MAOB, MAOA
79.6DRD1, DRD2, DRD4
89.4DRD1, DRD5, HTR2A
99.4HTR2A, DRD4, DRD3
10
Show member pathways
9.3HTR2A, DRD2, DRD1
11
Show member pathways
phenylalanine utilization37
noradrenaline and adrenaline degradation37
phenylalanine degradation IV37
9.3DBH, MAOA, MAOB
129.3MAOB, MAOA, DBH
13
Show member pathways
Nicotine Activity on Dopaminergic Neurons37
9.3DRD1, DRD2, DRD3, DRD4
149.2SLC6A3, MAOB
159.1SLC6A4, MAOA, HTR2A
169.1HTR2A, MAOA, SLC6A4
17
Show member pathways
citrulline-nitric oxide cycle37
arginine degradation I (arginase pathway)37
proline degradation37
glutamine degradation I37
proline biosynthesis I37
superpathway of citrulline metabolism37
proline biosynthesis II (from arginine)37
citrulline biosynthesis37
arginine degradation VI (arginase 2 pathway)37
Urea cycle and metabolism of amino groups37
asparagine biosynthesis I37
4-hydroxyproline degradation I37
citrulline degradation37
9.1ALDH18A1, MAOB, MAOA
189.0DRD4, DRD5, DRD3, DRD2, DRD1
19
Show member pathways
9.0DRD4, DRD5, DRD3, DRD2, DRD1
20
Show member pathways
8.5HTR2A, DRD4, DRD5, DRD3, DRD2, DRD1
21
Show member pathways
8.5HTR2A, DRD4, DRD5, DRD3, DRD2, DRD1
22
Show member pathways
8.5HTR2A, DRD4, DRD5, DRD3, DRD2, DRD1
23
Show member pathways
Serotonin Transporter Activity37
8.4DBH, MAOA, SLC6A4, SLC6A3
24
Show member pathways
8.2MAOA, MAOB, DRD2, DRD1, SLC6A3
25
Show member pathways
8.2MAOA, MAOB, DRD2, DRD1, SLC6A3
26
Show member pathways
6.3SLC6A3, HTR2A, MAOA, MAOB, DRD4, DRD5

Compounds for genes affiliated with Pathological Gambling

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Compounds related to Pathological Gambling according to GeneCards/GeneDecks:

(show top 50)    (show all 290)
idCompoundScoreTop Affiliating Genes
1cis flupentixol289.3DRD3, DRD2, DRD1, DRD5
2fluphenazine28 44 50 1112.0DRD4, DRD1, DRD2, DRD5, HTR2A
3rotigotine28 44 1110.9MAOB, DRD4, DRD3, DRD5, DRD2, DRD1
4(+)-butaclamol44 289.9DRD1, DRD2, DRD3, HTR2A, DRD4, DRD5
5lisuride44 28 1110.9HTR2A, DRD4, DRD1, DRD2, DRD3, DRD5
6dopac448.9DRD3, MAOB, DRD1, DBH, MAOA
7pergolide44 28 1110.9DRD1, HTR2A, DRD4, DRD5, DRD3, DRD2
8spiperone44 289.8DRD1, DRD2, DRD3, DRD4, HTR2A, DRD5
9cabergoline44 28 1110.8DRD1, DRD2, HTR2A, DRD4, DRD3, DRD5
10aripiprazole28 44 50 24 1112.8DRD5, DRD1, HTR2A, DRD4, DRD3, DRD2
11ziprasidone28 50 44 1111.8DRD4, DRD1, DRD2, DRD3, HTR2A, DRD5
12paliperidone44 119.7HTR2A, DRD3, DRD2, DRD1, DRD4
13chlorpromazine28 44 50 1111.7DRD1, DRD2, DRD3, DRD4, HTR2A, DRD5
14minaprine44 119.7DRD1, DRD2, MAOA, HTR2A, SLC6A4
15mhpg448.6DBH, MAOB, DRD4, MAOA, SLC6A4
16sulpiride44 28 1110.5DRD4, DRD3, DRD2, SLC6A3, DRD1
17catecholamine448.4DBH, DRD1, DRD3, DRD4, MAOB, MAOA
18iloperidone50 44 28 1111.4DRD1, DRD2, DRD3, HTR2A, DRD4
19piperazine44 119.4DRD4, DRD2, SLC6A3, DRD3, HTR2A
20ropinirole44 119.4DRD1, DRD2, DRD3, DRD5, DRD4, MAOB
21raclopride44 289.3DRD1, SLC6A3, DRD2, DRD3, HTR2A, DRD4
22quinpirole44 289.3HTR2A, DRD4, DRD3, DRD2, DRD1, SLC6A3
23d amphetamine448.1MAOA, MAOB, DRD2, DRD1, SLC6A4, SLC6A3
24pramipexole44 28 50 1111.1HTR2A, DRD4, DRD5, DRD3, DRD2, DRD1
25trimipramine44 50 1110.1HTR2A, DRD2, DRD1, SLC6A4, SLC6A3
26bromocriptine44 28 1110.0HTR2A, DRD4, DRD5, DRD3, DRD2, SLC6A3
27paroxetine44 50 28 1111.0SLC6A3, HTR2A, MAOA, DRD4, DRD3, SLC6A4
28risperidone44 50 28 61 24 1112.8HTR2A, DRD4, DRD3, DRD2, DRD1, SLC6A4
29amphetamine44 50 119.8MAOA, MAOB, DRD4, DRD2, DRD1, SLC6A4
30opiate447.7DRD3, DBH, DRD2, DRD1, SLC6A4, SLC6A3
31apomorphine28 44 119.6HTR2A, MAOB, DRD4, DRD5, DRD3, DRD2
32fluoxetine44 50 28 1110.6MAOB, DRD2, SLC6A3, SLC6A4, HTR2A, MAOA
33methylphenidate44 50 119.6SLC6A4, DRD1, MAOA, MAOB, DRD4, DRD5
34quetiapine44 50 28 24 1111.6DRD4, DRD5, DRD3, DRD2, DRD1, SLC6A4
35clozapine44 28 50 1110.6HTR2A, DRD4, DRD5, DRD3, DRD2, DRD1
366-hydroxydopamine447.6SLC6A3, DRD1, DRD2, DBH, MAOA, MAOB
37methamphetamine44 50 119.6MAOA, MAOB, DRD4, DRD3, DRD2, DRD1
38olanzapine44 50 28 24 1111.5HTR2A, DRD4, DRD5, DRD3, DRD2, DRD1
39cocaine44 118.4MAOB, DRD4, DRD3, DRD2, DRD1, DBH
40mptp447.4DBH, MAOA, MAOB, DRD3, DRD2, DRD1
41levodopa44 118.4DBH, MAOA, MAOB, DRD4, DRD5, DRD3
42gaba447.3DRD4, DRD2, DBH, DRD1, SLC6A4, MAOA
43imipramine44 28 50 24 1111.2DBH, HTR2A, MAOA, MAOB, DRD3, DRD1
44maoa447.2DBH, HTR2A, MAOA, MAOB, DRD4, DRD2
455-hydroxytryptamine447.1DBH, HTR2A, MAOA, MAOB, DRD4, DRD2
46haloperidol44 50 28 2 1111.1SLC6A4, SLC6A3, DRD1, DRD2, HTR2A, MAOB
47nicotine44 28 50 1110.1DRD1, SLC6A4, SLC6A3, DRD2, DRD3, DBH
48glutamate446.3MAOA, DRD3, MAOB, DRD1, DRD2, SLC6A4
49norepinephrine44 24 118.3MAOA, MAOB, DRD4, DRD5, DRD3, DRD2
50dopamine44 28 24 119.3DBH, HTR2A, MAOA, MAOB, DRD4, DRD5

GO Terms for genes affiliated with Pathological Gambling

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Cellular components related to Pathological Gambling according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430258.9SLC6A3, DRD4, HTR2A
2axonGO:0304248.5HTR2A, DRD2, SLC6A3
3integral component of plasma membraneGO:0058877.1SLC6A3, HTR2A, DRD4, DRD5, DRD3, DRD2
4plasma membraneGO:0058866.7EHD2, HTR2A, DRD4, DRD5, DRD3, DRD2

Biological processes related to Pathological Gambling according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idNameGO IDScoreTop Affiliating Genes
1sensitizationGO:04696010.3DRD1, DRD5
2cellular response to catecholamine stimulusGO:07187010.2DRD5, DRD1
3positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayGO:01057910.2DRD1, DRD5
4positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.2DRD4, DRD2
5regulation of locomotion involved in locomotory behaviorGO:09032510.2DRD2, DRD3
6negative regulation of voltage-gated calcium channel activityGO:190138610.2DRD4, DRD2
7negative regulation of dopamine receptor signaling pathwayGO:06016010.2DRD3, DRD2
8regulation of cAMP metabolic processGO:03081410.1DRD2, DRD3
9fear responseGO:04259610.1DBH, DRD4
10cerebral cortex GABAergic interneuron migrationGO:02185310.1DRD1, DRD2
11adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.0DRD5, DRD3, DRD1
12peristalsisGO:03043210.0DRD1, DRD2
13phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.0DRD5, DRD1, DRD2
14response to histamineGO:03477610.0DRD4, DRD3, DRD2
15adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.0DRD4, DRD2, DRD3
16regulation of dopamine uptake involved in synaptic transmissionGO:0515849.9DRD3, DRD1, DRD2
17long term synaptic depressionGO:0602929.9DRD1, DRD5
18negative regulation of protein secretionGO:0507099.9DRD4, DRD3, DRD2
19striatum developmentGO:0217569.9DRD2, DRD1
20negative regulation of blood pressureGO:0457769.9DRD3, DRD2, DRD5
21arachidonic acid secretionGO:0504829.9DRD2, DRD4, DRD3
22negative regulation of adenylate cyclase activityGO:0071949.9DRD2, DRD4, DRD3
23maternal behaviorGO:0427119.9DRD1, DBH
24regulation of dopamine secretionGO:0140599.8DRD3, HTR2A
25behavioral response to ethanolGO:0481499.8DRD2, DRD4, DBH
26G-protein coupled receptor internalizationGO:0020319.8DRD2, DRD3
27social behaviorGO:0351769.7SLC6A4, DRD3, DRD4
28negative regulation of synaptic transmission, glutamatergicGO:0519679.7DRD2, HTR2A
29dopamine metabolic processGO:0424179.7DRD1, DRD3, DRD2, DRD4
30dopamine transportGO:0158729.7DRD1, SLC6A3
31temperature homeostasisGO:0016599.7DRD2, DRD1, HTR2A
32adenohypophysis developmentGO:0219849.5DRD2, SLC6A3
33visual learningGO:0085429.5DRD3, DRD2, DRD1, DBH
34regulation of dopamine metabolic processGO:0420539.5SLC6A3, DRD1, DRD4
35positive regulation of renal sodium excretionGO:0358159.5DRD3, DRD2
36synaptic transmission, dopaminergicGO:0019639.4DRD5, DRD4, DRD3, DRD2, DRD1
37response to toxic substanceGO:0096369.4MAOB, DRD2, SLC6A4
38monoamine transportGO:0158449.4SLC6A4, SLC6A3
39dopamine catabolic processGO:0424209.3SLC6A3, MAOA, DBH
40cellular calcium ion homeostasisGO:0068749.2DRD4, DRD3, DRD2, DRD5, HTR2A
41response to iron ionGO:0100399.2SLC6A3, DRD2
42behavioral response to cocaineGO:0481489.2DRD3, HTR2A, DRD2, DRD1, DRD4
43response to cocaineGO:0422209.2DRD5, DRD3, DRD2, SLC6A3
44memoryGO:0076139.2DBH, DRD1, HTR2A, SLC6A4
45prepulse inhibitionGO:0601349.1SLC6A3, DRD1, DRD2, DRD3
46response to ethanolGO:0454719.1DRD3, MAOB, SLC6A3
47response to amphetamineGO:0019759.0DRD4, DBH, DRD5, DRD3, DRD2, DRD1
48locomotory behaviorGO:0076269.0DRD2, DBH, DRD3, SLC6A3
49synaptic transmissionGO:0072688.5SLC6A3, DRD5, MAOA, HTR2A, DBH
50response to drugGO:0424937.6DRD2, MAOB, SLC6A4, SLC6A3, HTR2A, DRD1

Molecular functions related to Pathological Gambling according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activity, coupled via GsGO:0015889.9DRD1, DRD5
2potassium channel regulator activityGO:0154599.8DRD2, DRD4
3dopamine neurotransmitter receptor activityGO:0049529.8DRD4, DRD5, DRD1
4dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.6DRD4, DRD3, DRD2
5primary amine oxidase activityGO:0081319.4MAOB, MAOA
6monoamine transmembrane transporter activityGO:0085049.0SLC6A4, SLC6A3
7dopamine bindingGO:0352408.4SLC6A3, DRD1, DRD2, DRD3, DRD5, DRD4
8drug bindingGO:0081448.3HTR2A, DRD4, DRD3, DRD2, SLC6A3

Products for genes affiliated with Pathological Gambling

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  • Antibodies
  • Proteins
  • Lysates

Sources for Pathological Gambling

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet