MCID: PTH002
MIFTS: 60

Pathological Gambling malady

Mental diseases category

Summaries for Pathological Gambling

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Sources:
9Disease Ontology, 35MedlinePlus, 66Wikipedia, 48OMIM, 34MalaCards
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MedlinePlus:35 Many people enjoy gambling, whether it's betting on a horse or playing poker on the internet. most people who gamble don't have a problem, but some lose control of their gambling. signs of problem gambling include always thinking about gambling lying about gambling spending work or family time gambling feeling bad after you gamble, but not quitting gambling with money you need for other things if you have concerns about your gambling, ask for help. your health care provider can work with you to find the treatment that's best for you. nih: natonal institutes of health

MalaCards: Pathological Gambling, also known as compulsive gambling, is related to parkinson's disease and schizophrenia. An important gene associated with Pathological Gambling is DRD5 (dopamine receptor D5), and among its related pathways are Biogenic Amine Synthesis and Dopamine metabolism. The compounds cis flupentixol and fluphenazine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and subthalamic nucleus, and related mouse phenotypes are adipose tissue and vision/eye.

Disease Ontology:9 An impulse control disorder that involves the uncontrollable impulse to gamble, irrespective of the interference the behaviour has on the individual's life.

Wikipedia:66 Problem gambling, or ludomania, is an urge to continuously gamble despite harmful negative consequences... more...

Description from OMIM:48 606349

Aliases & Classifications for Pathological Gambling

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Sources:
9Disease Ontology, 11DISEASES, 35MedlinePlus, 63UMLS, 48OMIM, 28ICD9CM, 59SNOMED-CT, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

pathological gambling 9 11
compulsive gambling 9 35
gambling, pathological 63


External Ids:

Disease Ontology9 DOID:12399
OMIM48 606349
ICD9CM28 312.31
MeSH36 D005715
ICD1026 F63.0

Related Diseases for Pathological Gambling

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Pathological Gambling via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson's disease30.9DRD1, SLC6A4, SLC6A3, DBH, HTR2A, MAOA
2schizophrenia30.7DRD3, HTR2A
3obsessive-compulsive disorder30.6DRD2, DRD1, SLC6A4, SLC6A3, HTR2A, MAOA
4personality disorder30.5MAOA, MAOB, DRD4, DRD3, DRD2, SLC6A4
5anxiety disorder30.4MAOA, SLC6A4
6drug addiction30.4DRD3, DRD2, DRD1, SLC6A3
7eating disorder30.4SLC6A3, SLC6A4, HTR2A
8nicotine dependence30.4SLC6A4, DRD2, DRD4
9dementia30.4HTR2A, MAOA, MAOB, SLC6A3
10substance abuse30.4DRD4, DRD3, DRD2, SLC6A4, SLC6A3
11bulimia nervosa30.4HTR2A, MAOA, SLC6A4
12alcohol dependence30.4HTR2A, MAOA, DRD4, DRD2, DRD1, SLC6A4
13alcohol abuse30.3DRD3, DRD2, SLC6A4, SLC6A3
14antisocial personality disorder30.2SLC6A4, SLC6A3, DRD2, MAOA, HTR2A
15bipolar disorder30.1HTR2A, MAOA, SLC6A4
16mood disorder30.1SLC6A4, SLC6A3, DRD1, DRD2, DRD3, DBH
17schizoaffective disorder30.1HTR2A, DRD4, DRD3, DRD2, SLC6A4
18cocaine dependence30.0DBH, DRD3, DRD2, SLC6A4, SLC6A3
19substance dependence30.0DRD4, DRD5, DRD3, DRD2, SLC6A4, SLC6A3
20obesity29.9HTR2A, MAOA, MAOB, DRD4, DRD2, SLC6A3
21blindness10.6
22frontotemporal dementia10.3
23restless legs syndrome10.3
24body dysmorphic disorder10.2
25alexithymia10.2
26prolactinoma10.2
27kleptomania10.2
28impulse control disorder10.2
29pyromania10.2
30melancholia10.1MAOA
31alcoholic psychosis10.1SLC6A4
32neuroleptic malignant syndrome10.1DRD2
33obsessive-compulsive personality disorder10.1SLC6A4
34delusional disorder10.1DRD2, DRD4
35lateral sclerosis10.1
36amyotrophic lateral sclerosis10.1
37dystonia10.1
38multiple sclerosis10.1
39x-linked dystonia-parkinsonism10.1
40brain injury10.1
41premature ejaculation10.1SLC6A4
42heroin dependence10.1DRD2, DRD4
43opiate dependence10.1DRD3, DRD2
44focal dystonia10.1DRD2, DRD5
45serotonin syndrome10.1MAOA, HTR2A
46endogenous depression10.1DRD3, SLC6A4
47dysthymic disorder10.1HTR2A, MAOA
48borderline personality disorder10.0SLC6A4, MAOA
49oppositional defiant disorder10.0DRD4, SLC6A3
50hepatic encephalopathy10.0MAOA, MAOB

Graphical network of the top 20 diseases related to Pathological Gambling:



Diseases related to pathological gambling

Symptoms for Pathological Gambling

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Sources:
48OMIM
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Clinical features from OMIM:

606349

Drugs & Therapeutics for Pathological Gambling

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Pathological Gambling

Drug clinical trials:

Search ClinicalTrials for Pathological Gambling

Search NIH Clinical Center for Pathological Gambling

Search CenterWatch for Pathological Gambling

Genetic Tests for Pathological Gambling

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Anatomical Context for Pathological Gambling

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34MalaCards
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MalaCards organs/tissues related to Pathological Gambling:

34
Brain, Cortex, Subthalamic nucleus, Testes, Prefrontal cortex, Heart, Skin, Pituitary

Animal Models for Pathological Gambling or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Pathological Gambling:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.8DBH, DRD3, DRD2, DRD1
2MP:00053918.6DRD1, DBH, ALDH18A1, DRD4, DRD5
3MP:00053858.1SLC6A4, DRD1, DRD2, DRD3, DRD5, MAOA
4MP:00107718.1SLC6A3, SLC6A4, DRD1, DRD2, DBH
5MP:00053697.9DRD1, HTR2A, SLC6A3, DRD2, SLC6A4
6MP:00053797.6HTR2A, DRD5, DRD2, SLC6A4, SLC6A3, DBH
7MP:00053766.8DRD4, DBH, MAOA, MAOB, DRD3, SLC6A4
8MP:00036316.6SLC6A3, MAOA, MAOB, DRD4, DRD5, DRD3
9MP:00053866.4SLC6A3, HTR2A, MAOA, MAOB, DRD4, DRD3

Publications for Pathological Gambling

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53PubMed
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Articles related to Pathological Gambling:

(show top 50)    (show all 493)
idTitleAuthorsYear
1
Waking self-hypnosis efficacy in cognitive-behavioral treatment for pathological gambling: an effectiveness clinical assay. (24256479)
2014
2
Cross-species approaches to pathological gambling: A review targeting sex differences, adolescent vulnerability and ecological validity of research tools. (23867802)
2013
3
How central is dopamine to pathological gambling or gambling disorder? (24391562)
2013
4
Pathological gambling in x-linked dystonia parkinsonism. (23629417)
2013
5
The Impulsivity and Sensation-Seeking Mediators of the Psychological Consequences of Pathological Gambling in Adolescence. (24297606)
2013
6
Pathological gambling in Parkinson's disease: subthalamic oscillations during economics decisions. (23554027)
2013
7
Commentary on Petry eta88al. (2013): Actus Reus--why it matters to pathological gambling treatment. (23418660)
2013
8
Pathological gambling in eating disorders: prevalence and clinical implications. (23759149)
2013
9
A proof of concept study of tolcapone for pathological gambling: relationships with COMT genotype and brain activation. (23953269)
2013
10
The relationship between universal human values and adolescent problem and pathological gambling. (22540439)
2012
11
Telescoping phenomenon in pathological gambling: association with gender and comorbidities. (23124186)
2012
12
Should pathological gambling be considered an addictive disorder? (22981047)
2012
13
Cognitive-behavioral therapy for pathological gambling in Parkinson's disease: a pilot controlled study. (22760081)
2012
14
Acamprosate and Baclofen were Not Effective in the Treatment of Pathological Gambling: Preliminary Blind Rater Comparison Study. (21713109)
2011
15
Dopamine release in ventral striatum during Iowa Gambling Task performance is associated with increased excitement levels in pathological gambling. (20883460)
2011
16
To gamble or not to gamble: at risk for craving and relapse--learned motivated attention in pathological gambling. (21453747)
2011
17
The prevalence and course of pathological gambling in the mood disorders. (20502951)
2011
18
The relationship of pathological gambling to criminality behavior in a sample of Polish male offenders. (22037748)
2011
19
Problem and pathological gambling in a sample of casino patrons. (20549549)
2011
20
A 6-month follow-up of imaginal desensitization plus motivational interviewing in the treatment of pathological gambling. (21318190)
2011
21
A(2A) adenosine receptor binding parameters in platelets from patients affected by pathological gambling. (21228607)
2011
22
Pathological gambling: an impulse control disorder? Measurement of impulsivity using neurocognitive tests. (20803888)
2010
23
Cognitive status of patients with Parkinson's disease and pathological gambling. (19727901)
2010
24
Noradrenergic function in pathological gambling: blunted growth hormone response to clonidine. (19028836)
2010
25
Impact of dopamine agonists on compulsive behaviors: a case series of pramipexole-induced pathological gambling. (20484726)
2010
26
Pathological gambling: influence of quality of life and psychological distress on abstinence after cognitive-behavioral inpatient treatment. (19357936)
2009
27
Is control a viable goal in the treatment of pathological gambling? (19118818)
2009
28
A randomized, double-blind, placebo-controlled trial of naltrexone in the treatment of concurrent alcohol use disorder and pathological gambling. (19340640)
2009
29
Comorbidity in pathological gambling: clinical variables, personality and treatment response. (23034347)
2009
30
Alexithymia and pathological gambling. (20155587)
2009
31
Pathological gambling and Parkinson disease]. (18807938)
2008
32
A double-blind, placebo-controlled study of the opiate antagonist naltrexone in the treatment of pathological gambling urges. (18384246)
2008
33
Pathological gambling after bilateral subthalamic nucleus stimulation in Parkinson disease. (17210626)
2007
34
Schizophrenia and pathological gambling. (17661194)
2007
35
Treatment of juvenile Parkinson disease and the recurrent emergence of pathologic gambling. (17356338)
2007
36
Dopamine agonist-induced pathological gambling in restless legs syndrome due to multiple sclerosis. (17230484)
2007
37
Pathological gambling. (16466112)
2006
38
A family study of pathological gambling. (16499975)
2006
39
Neuropsychological performance, impulsivity, and comorbid psychiatric illness in patients with pathological gambling undergoing treatment at the CORE Inpatient Treatment Center. (16466120)
2006
40
Prevalence and diagnostic correlates of DSM-IV pathological gambling in psychiatric outpatients. (16816991)
2006
41
Should the scope of addictive behaviors be broadened to include pathological gambling? (16930172)
2006
42
Update on pathological gambling. (16513043)
2006
43
Outcome of psychological treatments of pathological gambling: a review and meta-analysis. (16185203)
2005
44
The vulnerable faces of pathological gambling. (21179650)
2005
45
Pathological gambling and cross-addiction. (15968849)
2005
46
Recent research on the comorbidity of alcoholism and pathological gambling. (12605078)
2003
47
Nefazodone treatment of pathological gambling: a prospective open-label controlled trial. (12444818)
2002
48
Drugs can trigger pathological gambling. (11985369)
2002
49
Pathological gambling: a current perspective. (11447566)
2001
50
WITHDRAWN: Interventions for pathological gambling. (17636678)
2000

Variations for Pathological Gambling

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Expression for genes affiliated with Pathological Gambling

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pathological Gambling

Search GEO for disease gene expression data for Pathological Gambling.

Pathways for genes affiliated with Pathological Gambling

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 31KEGG, 54QIAGEN, 61Thomson Reuters, 52PharmGKB
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Pathways related to Pathological Gambling according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
catecholamine biosynthesis39
9.7MAOA, DBH
29.7MAOA, MAOB
3
Show member pathways
histamine biosynthesis39
9.7MAOA, MAOB
4
Show member pathways
choline degradation I39
glycine biosynthesis III39
serine and glycine biosynthesis39
glycine betaine degradation39
glycine biosynthesis39
9.7MAOB, MAOA
59.7MAOB, MAOA
69.7MAOB, MAOA
79.6DRD1, DRD2, DRD4
89.4DRD1, DRD5, HTR2A
99.4HTR2A, DRD4, DRD3
10
Show member pathways
9.3HTR2A, DRD2, DRD1
11
Show member pathways
phenylalanine utilization39
noradrenaline and adrenaline degradation39
phenylalanine degradation IV39
9.3DBH, MAOA, MAOB
129.3MAOB, MAOA, DBH
13
Show member pathways
Nicotine Activity on Dopaminergic Neurons39
9.3DRD1, DRD2, DRD3, DRD4
149.2SLC6A3, MAOB
159.1SLC6A4, MAOA, HTR2A
169.1HTR2A, MAOA, SLC6A4
17
Show member pathways
citrulline-nitric oxide cycle39
arginine degradation I (arginase pathway)39
proline degradation39
glutamine degradation I39
proline biosynthesis I39
superpathway of citrulline metabolism39
proline biosynthesis II (from arginine)39
citrulline biosynthesis39
arginine degradation VI (arginase 2 pathway)39
Urea cycle and metabolism of amino groups39
asparagine biosynthesis I39
4-hydroxyproline degradation I39
citrulline degradation39
9.1ALDH18A1, MAOB, MAOA
189.0DRD4, DRD5, DRD3, DRD2, DRD1
19
Show member pathways
9.0DRD4, DRD5, DRD3, DRD2, DRD1
20
Show member pathways
8.5HTR2A, DRD4, DRD5, DRD3, DRD2, DRD1
21
Show member pathways
8.5HTR2A, DRD4, DRD5, DRD3, DRD2, DRD1
22
Show member pathways
8.5HTR2A, DRD4, DRD5, DRD3, DRD2, DRD1
23
Show member pathways
Serotonin Transporter Activity39
8.4DBH, MAOA, SLC6A4, SLC6A3
24
Show member pathways
8.2MAOA, MAOB, DRD2, DRD1, SLC6A3
25
Show member pathways
8.2MAOA, MAOB, DRD2, DRD1, SLC6A3
26
Show member pathways
6.3SLC6A3, HTR2A, MAOA, MAOB, DRD4, DRD5

Compounds for genes affiliated with Pathological Gambling

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Sources:
30IUPHAR, 46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Pathological Gambling according to GeneCards/GeneDecks:

(show top 50)    (show all 290)
idCompoundScoreTop Affiliating Genes
1cis flupentixol309.3DRD3, DRD2, DRD1, DRD5
2fluphenazine30 46 52 1212.0DRD4, DRD1, DRD2, DRD5, HTR2A
3rotigotine30 46 1210.9MAOB, DRD4, DRD3, DRD5, DRD2, DRD1
4(+)-butaclamol46 309.9DRD1, DRD2, DRD3, HTR2A, DRD4, DRD5
5lisuride46 30 1210.9HTR2A, DRD4, DRD1, DRD2, DRD3, DRD5
6dopac468.9DRD3, MAOB, DRD1, DBH, MAOA
7pergolide46 30 1210.9DRD1, HTR2A, DRD4, DRD5, DRD3, DRD2
8spiperone46 309.8DRD1, DRD2, DRD3, DRD4, HTR2A, DRD5
9cabergoline46 30 1210.8DRD1, DRD2, HTR2A, DRD4, DRD3, DRD5
10aripiprazole30 46 52 25 1212.8DRD5, DRD1, HTR2A, DRD4, DRD3, DRD2
11ziprasidone30 52 46 1211.8DRD4, DRD1, DRD2, DRD3, HTR2A, DRD5
12paliperidone46 129.7HTR2A, DRD3, DRD2, DRD1, DRD4
13chlorpromazine30 46 52 1211.7DRD1, DRD2, DRD3, DRD4, HTR2A, DRD5
14minaprine46 129.7DRD1, DRD2, MAOA, HTR2A, SLC6A4
15mhpg468.6DBH, MAOB, DRD4, MAOA, SLC6A4
16sulpiride46 30 1210.5DRD4, DRD3, DRD2, SLC6A3, DRD1
17catecholamine468.4DBH, DRD1, DRD3, DRD4, MAOB, MAOA
18iloperidone52 46 30 1211.4DRD1, DRD2, DRD3, HTR2A, DRD4
19piperazine46 129.4DRD4, DRD2, SLC6A3, DRD3, HTR2A
20ropinirole46 129.4DRD1, DRD2, DRD3, DRD5, DRD4, MAOB
21raclopride46 309.3DRD1, SLC6A3, DRD2, DRD3, HTR2A, DRD4
22quinpirole46 309.3HTR2A, DRD4, DRD3, DRD2, DRD1, SLC6A3
23d amphetamine468.1MAOA, MAOB, DRD2, DRD1, SLC6A4, SLC6A3
24pramipexole46 30 52 1211.1HTR2A, DRD4, DRD5, DRD3, DRD2, DRD1
25trimipramine46 52 1210.1HTR2A, DRD2, DRD1, SLC6A4, SLC6A3
26bromocriptine46 30 1210.0HTR2A, DRD4, DRD5, DRD3, DRD2, SLC6A3
27paroxetine46 52 30 1211.0SLC6A3, HTR2A, MAOA, DRD4, DRD3, SLC6A4
28risperidone46 52 30 62 25 1212.8HTR2A, DRD4, DRD3, DRD2, DRD1, SLC6A4
29amphetamine46 52 129.8MAOA, MAOB, DRD4, DRD2, DRD1, SLC6A4
30opiate467.7DRD3, DBH, DRD2, DRD1, SLC6A4, SLC6A3
31apomorphine30 46 129.6HTR2A, MAOB, DRD4, DRD5, DRD3, DRD2
32fluoxetine46 52 30 1210.6MAOB, DRD2, SLC6A3, SLC6A4, HTR2A, MAOA
33methylphenidate46 52 129.6SLC6A4, DRD1, MAOA, MAOB, DRD4, DRD5
34quetiapine46 52 30 25 1211.6DRD4, DRD5, DRD3, DRD2, DRD1, SLC6A4
35clozapine46 30 52 1210.6HTR2A, DRD4, DRD5, DRD3, DRD2, DRD1
366-hydroxydopamine467.6SLC6A3, DRD1, DRD2, DBH, MAOA, MAOB
37methamphetamine46 52 129.6MAOA, MAOB, DRD4, DRD3, DRD2, DRD1
38olanzapine46 52 30 25 1211.5HTR2A, DRD4, DRD5, DRD3, DRD2, DRD1
39cocaine46 128.4MAOB, DRD4, DRD3, DRD2, DRD1, DBH
40mptp467.4DBH, MAOA, MAOB, DRD3, DRD2, DRD1
41levodopa46 128.4DBH, MAOA, MAOB, DRD4, DRD5, DRD3
42gaba467.3DRD4, DRD2, DBH, DRD1, SLC6A4, MAOA
43imipramine46 30 52 25 1211.2DBH, HTR2A, MAOA, MAOB, DRD3, DRD1
44maoa467.2DBH, HTR2A, MAOA, MAOB, DRD4, DRD2
455-hydroxytryptamine467.1DBH, HTR2A, MAOA, MAOB, DRD4, DRD2
46haloperidol46 52 30 3 1211.1SLC6A4, SLC6A3, DRD1, DRD2, HTR2A, MAOB
47nicotine46 30 52 1210.1DRD1, SLC6A4, SLC6A3, DRD2, DRD3, DBH
48glutamate466.3MAOA, DRD3, MAOB, DRD1, DRD2, SLC6A4
49norepinephrine46 25 128.3MAOA, MAOB, DRD4, DRD5, DRD3, DRD2
50dopamine46 30 25 129.3DBH, HTR2A, MAOA, MAOB, DRD4, DRD5

GO Terms for genes affiliated with Pathological Gambling

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Sources:
17Gene Ontology
See all sources

Cellular components related to Pathological Gambling according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430258.9SLC6A3, DRD4, HTR2A
2axonGO:0304248.5HTR2A, DRD2, SLC6A3
3integral component of plasma membraneGO:0058877.1SLC6A3, HTR2A, DRD4, DRD5, DRD3, DRD2
4plasma membraneGO:0058866.7EHD2, HTR2A, DRD4, DRD5, DRD3, DRD2

Biological processes related to Pathological Gambling according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idNameGO IDScoreTop Affiliating Genes
1sensitizationGO:04696010.3DRD1, DRD5
2cellular response to catecholamine stimulusGO:07187010.2DRD5, DRD1
3positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayGO:01057910.2DRD1, DRD5
4positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.2DRD4, DRD2
5regulation of locomotion involved in locomotory behaviorGO:09032510.2DRD2, DRD3
6negative regulation of voltage-gated calcium channel activityGO:190138610.2DRD4, DRD2
7negative regulation of dopamine receptor signaling pathwayGO:06016010.2DRD3, DRD2
8regulation of cAMP metabolic processGO:03081410.1DRD2, DRD3
9fear responseGO:04259610.1DBH, DRD4
10cerebral cortex GABAergic interneuron migrationGO:02185310.1DRD1, DRD2
11adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.0DRD5, DRD3, DRD1
12peristalsisGO:03043210.0DRD1, DRD2
13phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.0DRD5, DRD1, DRD2
14response to histamineGO:03477610.0DRD4, DRD3, DRD2
15adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.0DRD4, DRD2, DRD3
16regulation of dopamine uptake involved in synaptic transmissionGO:0515849.9DRD3, DRD1, DRD2
17long term synaptic depressionGO:0602929.9DRD1, DRD5
18negative regulation of protein secretionGO:0507099.9DRD4, DRD3, DRD2
19striatum developmentGO:0217569.9DRD2, DRD1
20negative regulation of blood pressureGO:0457769.9DRD3, DRD2, DRD5
21arachidonic acid secretionGO:0504829.9DRD2, DRD4, DRD3
22negative regulation of adenylate cyclase activityGO:0071949.9DRD2, DRD4, DRD3
23maternal behaviorGO:0427119.9DRD1, DBH
24regulation of dopamine secretionGO:0140599.8DRD3, HTR2A
25behavioral response to ethanolGO:0481499.8DRD2, DRD4, DBH
26G-protein coupled receptor internalizationGO:0020319.8DRD2, DRD3
27social behaviorGO:0351769.7SLC6A4, DRD3, DRD4
28negative regulation of synaptic transmission, glutamatergicGO:0519679.7DRD2, HTR2A
29dopamine metabolic processGO:0424179.7DRD1, DRD3, DRD2, DRD4
30dopamine transportGO:0158729.7DRD1, SLC6A3
31temperature homeostasisGO:0016599.7DRD2, DRD1, HTR2A
32adenohypophysis developmentGO:0219849.5DRD2, SLC6A3
33visual learningGO:0085429.5DRD3, DRD2, DRD1, DBH
34regulation of dopamine metabolic processGO:0420539.5SLC6A3, DRD1, DRD4
35positive regulation of renal sodium excretionGO:0358159.5DRD3, DRD2
36synaptic transmission, dopaminergicGO:0019639.4DRD5, DRD4, DRD3, DRD2, DRD1
37response to toxic substanceGO:0096369.4MAOB, DRD2, SLC6A4
38monoamine transportGO:0158449.4SLC6A4, SLC6A3
39dopamine catabolic processGO:0424209.3SLC6A3, MAOA, DBH
40cellular calcium ion homeostasisGO:0068749.2DRD4, DRD3, DRD2, DRD5, HTR2A
41response to iron ionGO:0100399.2SLC6A3, DRD2
42behavioral response to cocaineGO:0481489.2DRD3, HTR2A, DRD2, DRD1, DRD4
43response to cocaineGO:0422209.2DRD5, DRD3, DRD2, SLC6A3
44memoryGO:0076139.2DBH, DRD1, HTR2A, SLC6A4
45prepulse inhibitionGO:0601349.1SLC6A3, DRD1, DRD2, DRD3
46response to ethanolGO:0454719.1DRD3, MAOB, SLC6A3
47response to amphetamineGO:0019759.0DRD4, DBH, DRD5, DRD3, DRD2, DRD1
48locomotory behaviorGO:0076269.0DRD2, DBH, DRD3, SLC6A3
49synaptic transmissionGO:0072688.5SLC6A3, DRD5, MAOA, HTR2A, DBH
50response to drugGO:0424937.6DRD2, MAOB, SLC6A4, SLC6A3, HTR2A, DRD1

Molecular functions related to Pathological Gambling according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activity, coupled via GsGO:0015889.9DRD1, DRD5
2potassium channel regulator activityGO:0154599.8DRD2, DRD4
3dopamine neurotransmitter receptor activityGO:0049529.8DRD4, DRD5, DRD1
4dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.6DRD4, DRD3, DRD2
5primary amine oxidase activityGO:0081319.4MAOB, MAOA
6monoamine transmembrane transporter activityGO:0085049.0SLC6A4, SLC6A3
7dopamine bindingGO:0352408.4SLC6A3, DRD1, DRD2, DRD3, DRD5, DRD4
8drug bindingGO:0081448.3HTR2A, DRD4, DRD3, DRD2, SLC6A3

Products for genes affiliated with Pathological Gambling

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pathological Gambling

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet