MCID: PTH002
MIFTS: 58

Pathological Gambling malady

Neuronal diseases category

Summaries for Pathological Gambling

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Many people enjoy gambling, whether it's betting on a horse or playing poker on the internet. most people who gamble don't have a problem, but some lose control of their gambling. signs of problem gambling include always thinking about gambling lying about gambling spending work or family time gambling feeling bad after you gamble, but not quitting gambling with money you need for other things if you have concerns about your gambling, ask for help. your health care provider can work with you to find the treatment that's best for you. nih: natonal institutes of health

MalaCards: Pathological Gambling, also known as compulsive gambling, is related to parkinson's disease and personality disorder. An important gene associated with Pathological Gambling is DRD4 (dopamine receptor D4), and among its related pathways are phenylalanine utilization and melatonin degradation II. The compounds cis flupentixol and rotigotine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and subthalamic nucleus, and related mouse phenotypes are cardiovascular system and normal.

Disease Ontology:8 An impulse control disorder that involves the uncontrollable impulse to gamble, irrespective of the interference the behaviour has on the individual's life.

Wikipedia:63 Problem gambling, or ludomania, is an urge to continuously gamble despite harmful negative consequences... more...

Description from OMIM:46 606349

Aliases & Classifications for Pathological Gambling

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8Disease Ontology, 10DISEASES, 33MedlinePlus, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 46OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

pathological gambling 8 10
compulsive gambling 8 33
gambling, pathological 60


External Ids:

Disease Ontology8 DOID:12399
ICD9CM27 312.31
MeSH34 D005715
OMIM46 606349
ICD1025 F63.0

Related Diseases for Pathological Gambling

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pathological Gambling via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson's disease31.2DRD1, HTR2A, DRD2, DRD3, DRD4, SLC6A3
2personality disorder30.8DRD2, DRD3, MAOB, MAOA, SLC6A3, DRD4
3obsessive-compulsive disorder30.8DRD3, DRD4, MAOA, SLC6A3, SLC6A4, DRD2
4alcohol dependence30.6DRD4, SLC6A4, DRD1, MAOA, DRD2, HTR2A
5schizophrenia30.5DRD3, HTR2A
6restless legs syndrome30.4DRD2
7substance abuse30.4DRD2, DRD3, DRD4, SLC6A3, SLC6A4
8dementia30.4MAOA, HTR2A, SLC6A3, MAOB
9eating disorder30.4HTR2A, SLC6A3, SLC6A4
10mood disorder30.3DBH, MAOB, MAOA, SLC6A4, SLC6A3, GRIN1
11obsessive-compulsive personality disorder30.3SLC6A4
12nicotine dependence30.3DRD2, DRD4, SLC6A4
13bulimia nervosa30.3SLC6A4, MAOA, HTR2A
14alcohol abuse30.3DRD2, DRD3, SLC6A3, SLC6A4
15antisocial personality disorder30.2SLC6A3, HTR2A, MAOA, DRD2, SLC6A4
16anxiety disorder30.2HTR2A, MAOB, DRD2, SLC6A3, MAOA, SLC6A4
17amyotrophic lateral sclerosis30.0SLC6A3, MAOB, RTN4
18bipolar disorder30.0HTR2A, MAOA, SLC6A4
19schizoaffective disorder30.0SLC6A4, DRD4, DRD2, HTR2A, DRD3
20substance dependence30.0SLC6A3, SLC6A4, DRD5, DRD3, DRD2, DRD4
21obesity30.0DRD2, SLC6A3, MAOB, MAOA, DRD4, HTR2A
22cocaine dependence30.0DRD2, DRD3, DBH, SLC6A3, SLC6A4
23frontotemporal dementia10.3
24impulse control disorder10.3
25prolactinoma10.2
26alexithymia10.2
27body dysmorphic disorder10.2
28kleptomania10.2
29pyromania10.2
30lateral sclerosis10.0
31multiple sclerosis10.0
32sexual disorder10.0
33withdrawal disorder10.0
34blindness10.0MAOB
35myoclonus-dystonia10.0DRD2
36huntington's disease10.0DRD2
37heroin dependence10.0DRD4, DRD2
38alcoholic psychosis10.0SLC6A4
39delusional disorder10.0DRD2, DRD4
40melancholia10.0MAOA
41attention deficit hyperactivity disorder10.0DRD4, SLC6A3
42striatonigral degeneration10.0SLC6A3, DRD2
43wilson disease10.0SLC6A3, DRD2
44borderline personality disorder10.0MAOA, SLC6A4
45opiate dependence10.0DRD3, DRD2
46hepatic encephalopathy10.0MAOB, MAOA
47focal dystonia10.0DRD2, DRD5
48chronic fatigue syndrome10.0MAOA, SLC6A4
49endogenous depression10.0SLC6A4, DRD3
50neuroblastoma10.0DBH

Graphical network of the top 20 diseases related to Pathological Gambling:



Diseases related to pathological gambling

Clinical Features for Pathological Gambling

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Sources:
46OMIM
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Clinical features from OMIM:

606349

Drugs & Therapeutics for Pathological Gambling

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Pathological Gambling

Drug clinical trials:

Search ClinicalTrials for Pathological Gambling

Search NIH Clinical Center for Pathological Gambling

Search CenterWatch for Pathological Gambling

Genetic Tests for Pathological Gambling

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Anatomical Context for Pathological Gambling

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32MalaCards
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MalaCards organs/tissues related to Pathological Gambling:

32
Brain, Cortex, Subthalamic nucleus, Testes, Prefrontal cortex, Heart, Skin, Pituitary

Animal Models for Pathological Gambling or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pathological Gambling:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.2DRD1, DRD2, DRD3, DRD5, GRIN1, MAOA
2MP:00028737.8DRD5, GRIN1, DBH, RTN4, SLC6A3, SLC6A4
3MP:00053767.7DRD1, DRD2, DRD3, DRD4, GRIN1, MAOA
4MP:00053797.7HTR2A, DRD2, DRD5, DBH, EPHB2, SLC6A3
5MP:00053866.4DRD4, DRD3, DRD2, DRD1, HTR2A, GRIN1
6MP:00107686.0GRIN1, PPP4C, DRD3, DRD2, DRD1, DNAJB6
7MP:00036315.9SLC6A4, DRD1, DRD2, DRD3, DRD4, DRD5

Publications for Pathological Gambling

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50PubMed
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Articles related to Pathological Gambling:

(show top 50)    (show all 498)
idTitleAuthorsYear
1
The Impulsivity and Sensation-Seeking Mediators of the Psychological Consequences of Pathological Gambling in Adolescence. (24297606)
2013
2
Telescoping phenomenon in pathological gambling: association with gender and comorbidities. (23124186)
2012
3
Impaired probability estimation and decision-making in pathological gambling poker players. (21484601)
2012
4
Pathological gambling in a psychiatric sample. (21489418)
2012
5
A(2A) adenosine receptor binding parameters in platelets from patients affected by pathological gambling. (21228607)
2011
6
Treatments for PTSD and pathological gambling: what do patients want? (20517639)
2011
7
Is pathological gambling in Parkinson's disease reduced by amantadine? (21280095)
2011
8
Memantine shows promise in reducing gambling severity and cognitive inflexibility in pathological gambling: a pilot study. (20721537)
2010
9
Pathological gambling from dopamine agonist and deep brain stimulation of the nucleus tegmenti pedunculopontine. (22798481)
2010
10
Serotonin function in pathological gambling: blunted growth hormone response to sumatriptan. (19825906)
2010
11
Treatment of pathological gambling with naltrexone pharmacotherapy and brief intervention: a pilot study. (21150845)
2010
12
Parkinson's disease and pathological gambling: results from a functional MRI study. (20976739)
2010
13
Pathological gambling associated with cabergoline in a case of recurrent depression. (22495606)
2009
14
Clinical follow up of pathological gambling in Parkinson's disease in the West Scotland study. (19908308)
2009
15
Pathological gambling and criminality. (19571753)
2009
16
Pathological gambling and Parkinson disease]. (18807938)
2008
17
Clinical correlates of pathological gambling symptoms in patients with epilepsy. (18479402)
2008
18
Pathological gambling: an update on neuropathophysiology and pharmacotherapy. (18193924)
2008
19
Association of cognitive distortions with problem and pathological gambling in adult male twins. (18710784)
2008
20
Functional abnormalities underlying pathological gambling in Parkinson disease. (19064747)
2008
21
DSM-IV pathological gambling in the National Comorbidity Survey Replication. (18257941)
2008
22
Pathological gambling after bilateral subthalamic nucleus stimulation in Parkinson disease. (17210626)
2007
23
Treatment of juvenile Parkinson disease and the recurrent emergence of pathologic gambling. (17356338)
2007
24
Internet gambling and other pathological gambling in Parkinson's disease: a case series. (17266073)
2007
25
Lithium and topiramate association in the treatment of comorbid pathological gambling and bipolar disorder. (17558627)
2007
26
Racial/ethnic variation in the reliability of DSM-IV pathological gambling disorder. (17632244)
2007
27
Treatment goal selection for female pathological gambling: a comparison of abstinence and controlled gambling. (17479359)
2007
28
Pathological gambling in Parkinson's disease: risk factors and differences from dopamine dysregulation. An analysis of published case series. (17580327)
2007
29
Genetic and environmental contributions to pathological gambling symptoms in a 10-year follow-up. (17539377)
2007
30
Prevention of pathological gambling: a randomized controlled trial. (17530493)
2007
31
The effect of pathological gambling on families, marriages, and children. (17667890)
2007
32
Pathological gambling associated with cabergoline therapy in a patient with a pituitary prolactinoma. (18070857)
2007
33
A psychometric evaluation of the DSM-IV pathological gambling diagnostic criteria. (17009124)
2006
34
Multicenter investigation of the opioid antagonist nalmefene in the treatment of pathological gambling. (16449486)
2006
35
Prevalence of pathological gambling in patients with Parkinson's disease. (17044068)
2006
36
Sex differences in subclinical and DSM-IV pathological gambling: results from the National Epidemiologic Survey on Alcohol and Related Conditions. (16650342)
2006
37
Pathological gambling and cross-addiction. (15968849)
2005
38
Problem and pathological gambling among college athletes. (16402758)
2005
39
Pathological gambling and age: differences in personality, psychopathology, and response to treatment variables. (15621411)
2005
40
Reliability and validity of the pathological gambling adaptation of the Yale-Brown Obsessive-Compulsive Scale (PG-YBOCS). (16311876)
2005
41
Validation of the lie/bet screen for pathological gambling on two normal population data sets. (15666948)
2004
42
Pathological gambling in two patients on dopamine replacement therapy for Parkinson's disease. (15221629)
2004
43
Frontotemporal dementia presenting with pathological gambling. (14990769)
2004
44
Node-link-mapping-enhanced group treatment for pathological gambling. (14667422)
2004
45
DSM-IV-J criteria: a scoring error that may be modifying the estimates of pathological gambling among youths. (14634301)
2003
46
Disrupted sensory gating in pathological gambling. (12915292)
2003
47
Pathological gambling and comorbid substance use. (12060192)
2002
48
Pathological gambling--a review of current clinical considerations. (12537321)
2002
49
Pathological gambling. (11448261)
2001
50
Studies of the 48 bp repeat polymorphism of the DRD4 gene in impulsive, compulsive, addictive behaviors: Tourette syndrome, ADHD, pathological gambling, and substance abuse. (10402503)
1999

Genetic Variations for Pathological Gambling

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Expression for genes affiliated with Pathological Gambling

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pathological Gambling

Search GEO for disease gene expression data for Pathological Gambling.

Pathways for genes affiliated with Pathological Gambling

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Sources:
37NCBI BioSystems Database, 53Reactome, 29KEGG, 49PharmGKB, 12EMD Millipore, 51QIAGEN
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Pathways related to Pathological Gambling according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0MAOB, MAOA
2
Hide members
10.0MAOA, MAOB
3
Hide members
9.9SLC6A3, MAOA
4
Hide members
9.7MAOA, MAOB, ALDH18A1
5
Hide members
9.6DRD1, DRD2, DRD3, DRD4
69.6DRD4, DRD3, HTR2A
79.6DRD1, DRD2, DRD4, GRIN1
8
Hide members
9.5MAOA, MAOB, DBH
9
Tyrosine metabolism p.1 (dopamine)
Hide members
9.5DBH, MAOB, MAOA
10
Hide members
9.4DRD1, DRD2, DRD3, DRD4, DRD5
119.4DRD1, DRD2, DRD3, DRD4, DRD5
129.3DBH, SLC6A3, SLC6A4
139.3GRIN1, DRD5, DRD1, HTR2A
149.2DRD1, DRD2, DRD3, DRD4, DRD5, GRIN1
159.1HTR2A, GRIN1, MAOA, SLC6A4
16
Hide members
8.9DRD1, DRD2, GRIN1, MAOA, MAOB, SLC6A3
178.9DRD1, DRD2, GRIN1, MAOA, MAOB, SLC6A3
18
Hide members
8.6HTR2A, DRD1, DRD2, DRD3, DRD4, DRD5
19
Hide members
8.3SLC6A4, HTR2A, DRD1, DRD2, DRD3, DRD4
20
Hide members
7.6HTR2A, DRD1, DRD2, DRD3, DRD4, DRD5
21
Hide members
7.4HTR2A, DRD1, DRD2, DRD3, DRD4, DRD5

Compounds for genes affiliated with Pathological Gambling

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Sources:
28IUPHAR, 44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Pathological Gambling according to GeneCards/GeneDecks:

(show top 50)    (show all 276)
idCompoundScoreTop Affiliating Genes
1cis flupentixol289.6DRD1, DRD5, DRD3, DRD2
2rotigotine44 28 1111.6DRD4, DRD3, DRD2, DRD1, MAOB, DRD5
3fluphenazine28 44 1111.4HTR2A, DRD5, DRD2, DRD1, DRD4
4(+)-butaclamol28 4410.4DRD1, DRD2, DRD3, DRD4, DRD5, HTR2A
5dopac449.3MAOB, MAOA, DRD3, DRD1, DBH
6sulpiride44 28 1111.3SLC6A3, DRD2, DRD4, DRD1, DRD3
7spiperone28 4410.3DRD5, DRD4, DRD3, DRD2, DRD1, HTR2A
8lisuride28 44 1111.3DRD3, DRD5, HTR2A, DRD4, DRD2, DRD1
9pergolide28 44 1111.3HTR2A, DRD1, DRD2, DRD3, DRD4, DRD5
10Methotrimeprazine119.3DRD5, DRD4, HTR2A, DRD1, DRD2, DRD3
11d amphetamine449.3DRD1, DRD2, MAOA, MAOB, SLC6A3, SLC6A4
12cabergoline28 44 1111.2HTR2A, DRD4, DRD1, DRD5, DRD3, DRD2
13aripiprazole28 49 44 11 2413.2DRD1, DRD4, DRD5, DRD3, DRD2, HTR2A
14nmda44 2810.2EPHB2, SLC6A3, MAOA, GRIN1, MAOB
15piperazine44 1110.2SLC6A3, HTR2A, DRD4, DRD3, DRD2
16raclopride44 2810.2SLC6A3, DRD4, DRD2, DRD1, DRD3, HTR2A
17ziprasidone49 28 44 1112.2DRD5, DRD3, DRD2, HTR2A, DRD4, DRD1
18minaprine44 1110.2MAOA, DRD2, DRD1, HTR2A, SLC6A4
19quinpirole44 2810.2DRD2, SLC6A3, DRD4, HTR2A, DRD1, DRD3
20mhpg449.1SLC6A4, DBH, MAOA, DRD4, MAOB
21ropinirole44 1110.1DRD5, MAOB, DRD4, DRD3, HTR2A, DRD1
22MMDA119.1HTR2A, MAOA, SLC6A4, SLC6A3, MAOB
23pramipexole44 49 28 1112.0HTR2A, DRD1, DRD2, DRD3, DRD4, DRD5
24amphetamine44 1110.0DRD1, DRD4, MAOA, MAOB, SLC6A3, SLC6A4
25quetiapine44 49 28 11 2413.0DRD5, HTR2A, SLC6A3, DRD1, DRD2, DRD3
26chlorpromazine44 28 49 1112.0HTR2A, DRD5, DRD4, DRD3, DRD2, DRD1
27bromocriptine28 44 1111.0DRD2, DRD4, DRD5, DRD1, HTR2A, SLC6A3
28olanzapine49 44 28 11 2412.9HTR2A, SLC6A3, DRD5, DRD4, DRD3, DRD2
29paroxetine44 49 28 1111.9HTR2A, DRD3, DRD4, SLC6A4, SLC6A3, MAOA
30catecholamine448.9DBH, MAOB, DRD5, DRD4, DRD1, DRD3
31methamphetamine44 49 1110.9SLC6A4, DRD1, DRD2, DRD3, DRD4, MAOA
32methylphenidate44 49 1110.9MAOB, SLC6A3, SLC6A4, MAOA, DRD5, DRD1
336-hydroxydopamine448.8DRD4, DRD1, DRD2, DRD3, MAOA, DBH
34risperidone28 44 49 59 11 2413.8DRD4, DRD3, DRD2, DRD1, SLC6A3, HTR2A
35apomorphine44 28 1110.8SLC6A3, MAOB, DRD5, HTR2A, DRD1, DRD2
36trimipramine49 44 1110.7SLC6A3, SLC6A4, DRD1, DRD2, HTR2A
37clozapine44 28 49 1111.6SLC6A4, SLC6A3, DRD5, DRD4, DRD3, DRD2
38levodopa44 119.6DRD5, MAOA, MAOB, DBH, SLC6A3, DRD4
39haloperidol44 28 2 49 1112.4HTR2A, DRD1, DRD2, DRD3, DRD4, DRD5
40cocaine44 119.3SLC6A4, DBH, SLC6A3, MAOB, GRIN1, DRD1
41maoa448.3DRD2, DRD4, MAOA, MAOB, DBH, SLC6A3
42mptp448.3SLC6A4, SLC6A3, DBH, MAOA, GRIN1, DRD3
43imipramine44 49 28 11 2412.3SLC6A3, SLC6A4, HTR2A, DRD1, MAOA, MAOB
44gaba448.2DBH, DRD2, GRIN1, MAOA, MAOB, SLC6A3
45fluoxetine49 44 28 1111.2HTR2A, DRD2, SLC6A3, MAOA, MAOB, SLC6A4
465-hydroxytryptamine448.2HTR2A, DRD4, DRD2, SLC6A4, MAOA, MAOB
47nicotine44 49 28 1111.1SLC6A4, SLC6A3, DRD4, GRIN1, MAOA, MAOB
48glutamate447.5ALDH18A1, DRD3, DRD2, DRD1, SLC6A3, MAOA
49norepinephrine44 11 249.4DRD3, DRD5, DRD4, GRIN1, MAOA, DRD2
50dopamine44 28 11 2410.4HTR2A, DRD1, DRD2, DRD3, DRD4, DBH

GO Terms for genes affiliated with Pathological Gambling

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16Gene Ontology
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Cellular components related to Pathological Gambling according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendritic spineGO:0431979.8GRIN1, DRD4, DRD2
2axonGO:0304248.9HTR2A, DRD2, EPHB2, SLC6A3
3dendriteGO:0304258.7EPHB2, DNER, GRIN1, DRD2
4neuronal cell bodyGO:0430258.2DRD4, DNER, EPHB2, RTN4, SLC6A3
5integral to plasma membraneGO:0058877.6SLC6A4, HTR2A, DRD1, DRD2, DRD3, DRD4
6plasma membraneGO:0058865.8DRD4, DRD3, DRD2, DRD1, HTR2A, DRD5

Biological processes related to Pathological Gambling according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idNameGO IDScoreTop Affiliating Genes
1sensitizationGO:04696010.4DRD1, DRD5
2positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.4DRD2, DRD4
3negative regulation of dopamine receptor signaling pathwayGO:06016010.4DRD3, DRD2
4negative regulation of voltage-gated calcium channel activityGO:190138610.4DRD4, DRD2
5olfactory learningGO:00835510.3GRIN1, DRD4
6regulation of cAMP metabolic processGO:03081410.3DRD2, DRD3
7cellular response to catecholamine stimulusGO:07187010.3DRD5, DRD1
8response to histamineGO:03477610.3DRD2, DRD3, DRD4
9adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.3DRD2, DRD3, DRD4
10adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.3DRD3, DRD1, DRD5
11conditioned taste aversionGO:00166110.3DRD1, GRIN1
12regulation of dopamine uptake involved in synaptic transmissionGO:05158410.3DRD3, DRD1, DRD2
13cerebral cortex GABAergic interneuron migrationGO:02185310.2DRD2, DRD1
14negative regulation of protein secretionGO:05070910.2DRD4, DRD3, DRD2
15arachidonic acid secretionGO:05048210.2DRD4, DRD3, DRD2
16phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.2DRD2, DRD1, DRD5
17positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayGO:01057910.2DRD1, DRD5
18negative regulation of adenylate cyclase activityGO:00719410.2DRD3, DRD4, DRD2
19dopamine transportGO:01587210.2SLC6A3, DRD1
20negative regulation of blood pressureGO:04577610.2DRD2, DRD3, DRD5
21regulation of dopamine metabolic processGO:04205310.2DRD1, DRD4, SLC6A3
22fear responseGO:04259610.1DRD4, DBH
23response to morphineGO:04327810.1DRD3, DRD2, GRIN1
24adenohypophysis developmentGO:02198410.1SLC6A3, DRD2
25peristalsisGO:03043210.1DRD2, DRD1
26dopamine metabolic processGO:04241710.1DRD1, DRD2, DRD3, DRD4
27behavioral response to cocaineGO:04814810.1DRD1, DRD4, DRD3, DRD2
28behavioral response to ethanolGO:04814910.0DRD2, DRD4, DBH
29monoamine transportGO:01584410.0SLC6A4, SLC6A3
30long term synaptic depressionGO:06029210.0DRD1, DRD5
31response to cocaineGO:0422209.9DRD3, DRD5, SLC6A3, DRD2
32regulation of dopamine secretionGO:0140599.9HTR2A, DRD3, DRD2
33response to iron ionGO:0100399.9SLC6A3, DRD2
34dopamine catabolic processGO:0424209.9SLC6A3, DBH, MAOA
35synaptic transmission, dopaminergicGO:0019639.9DRD4, DRD2, DRD5, DRD1, DRD3
36temperature homeostasisGO:0016599.9DRD1, HTR2A, DRD2
37social behaviorGO:0351769.9GRIN1, DRD4, DRD3, SLC6A4
38synapse assemblyGO:0074169.8DRD2, DRD1, DNER
39response to ethanolGO:0454719.8GRIN1, SLC6A3, DRD3, MAOB
40G-protein coupled receptor internalizationGO:0020319.7DRD3, DRD2
41negative regulation of synaptic transmission, glutamatergicGO:0519679.7HTR2A, DRD2
42response to toxic substanceGO:0096369.7DRD2, SLC6A4, MAOB
43prepulse inhibitionGO:0601349.7GRIN1, DRD2, DRD1, DRD3, SLC6A3
44locomotory behaviorGO:0076269.6DRD3, SLC6A3, DBH, DRD2
45visual learningGO:0085429.5GRIN1, DBH, DRD3, DRD2, DRD1
46memoryGO:0076139.3SLC6A4, DRD1, HTR2A, DBH
47cellular calcium ion homeostasisGO:0068749.3DRD4, HTR2A, DRD2, DRD3, GRIN1, DRD5
48response to amphetamineGO:0019759.2DRD2, DRD3, DRD4, DRD5, GRIN1, DRD1
49synaptic transmissionGO:0072688.8HTR2A, GRIN1, MAOA, DBH, SLC6A3, DRD5
50response to drugGO:0424938.8HTR2A, DRD1, DRD2, SLC6A4, SLC6A3, MAOB

Molecular functions related to Pathological Gambling according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activity, coupled via GsGO:00158810.1DRD1, DRD5
2primary amine oxidase activityGO:00813110.0MAOB, MAOA
3dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.0DRD4, DRD3, DRD2
4dopamine neurotransmitter receptor activityGO:0049529.9DRD5, DRD4, DRD1
5monoamine transmembrane transporter activityGO:0085049.5SLC6A4, SLC6A3
6dopamine bindingGO:0352409.3SLC6A3, DRD5, DRD4, DRD3, DRD2, DRD1
7drug bindingGO:0081449.2HTR2A, DRD2, DRD3, DRD4, SLC6A3
8protein bindingGO:0055155.4DRD1, DRD2, DRD3, DRD4, PPP4C, GRIN1

Products for genes affiliated with Pathological Gambling

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pathological Gambling

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet