MCID: PDG002
MIFTS: 29

Pdgfrb-Associated Chronic Eosinophilic Leukemia

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Pdgfrb-Associated Chronic Eosinophilic Leukemia

MalaCards integrated aliases for Pdgfrb-Associated Chronic Eosinophilic Leukemia:

Name: Pdgfrb-Associated Chronic Eosinophilic Leukemia 49 24 69
Atypical Philadelphia-Negative Chronic Myeloid Leukemia 49 24
Primary Eosinophilia with Chronic Myeloproliferative Disorder 24
Clonal Eosinophilia with Chronic Myeloproliferative Disorder 24
Chronic Myeloproliferative Disorder with Eosinophilia 24
Leukemia, Myelomonocytic, Chronic 69
Chronic Myelomonocytic Leukemia 24

Classifications:



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Summaries for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Genetics Home Reference : 24 PDGFRB-associated chronic eosinophilic leukemia is a type of cancer of blood-forming cells. It is characterized by an elevated number of white blood cells called eosinophils in the blood. These cells help fight infections by certain parasites and are involved in the inflammation associated with allergic reactions. However, these circumstances do not account for the increased number of eosinophils in PDGFRB-associated chronic eosinophilic leukemia. Some people with this condition have an increased number of other types of white blood cells, such as neutrophils or mast cells, in addition to eosinophils. People with this condition can have an enlarged spleen (splenomegaly) or enlarged liver (hepatomegaly). Some affected individuals develop skin rashes, likely as a result of an abnormal immune response due to the increased number of eosinophils.

MalaCards based summary : Pdgfrb-Associated Chronic Eosinophilic Leukemia, also known as atypical philadelphia-negative chronic myeloid leukemia, is related to chronic myelomonocytic leukemia and juvenile myelomonocytic leukemia, and has symptoms including night sweats, fever and fatigue. Affiliated tissues include neutrophil, myeloid and skin.

Related Diseases for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Diseases related to Pdgfrb-Associated Chronic Eosinophilic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
# Related Disease Score Top Affiliating Genes
1 chronic myelomonocytic leukemia 12.5
2 juvenile myelomonocytic leukemia 12.0
3 myelodysplastic syndrome 11.5
4 leukemia 11.1
5 myelodysplastic myeloproliferative cancer 11.1
6 myeloid leukemia 10.5
7 leukemia, acute myeloid 10.4
8 leukemia, chronic myeloid 10.2
9 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
10 refractory anemia 10.2
11 systemic mastocytosis 10.2
12 myelofibrosis 10.2
13 thrombocytopenia 10.1
14 atypical chronic myeloid leukemia 10.1
15 chronic neutrophilic leukemia 10.1
16 myeloproliferative neoplasm 10.1
17 leukemia, chronic lymphocytic 2 10.1
18 leukemia, b-cell, chronic 10.1
19 acute leukemia 10.1
20 leukemia, chronic lymphocytic 10.1
21 hematopoietic stem cell transplantation 10.1
22 myeloma, multiple 10.0
23 lymphoma 10.0
24 lymphoblastic leukemia 10.0
25 sarcoma 10.0
26 blood group, i system 10.0
27 purpura 10.0
28 histiocytosis 10.0
29 vasculitis 10.0
30 graft-versus-host disease 10.0
31 dermatitis 9.9
32 ring chromosome y syndrome 9.9
33 hemopericardium 9.9
34 antiphospholipid syndrome 9.9
35 chronic graft versus host disease 9.9
36 monocytic leukemia 9.9
37 dendritic cell tumor 9.9
38 pericardial effusion 9.9
39 pyoderma gangrenosum 9.9
40 fibrosis of extraocular muscles, congenital, 1 9.9
41 polyneuropathy 9.9
42 pyoderma 9.9
43 pyridoxine-refractory autosomal recessive sideroblastic anemia 9.9
44 thrombocytopenia due to platelet alloimmunization 9.9
45 splenomegaly 9.9
46 mast-cell leukemia 9.9
47 aortitis 9.9
48 generalized eruptive histiocytosis 9.9
49 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 9.9
50 polykaryocytosis inducer 9.7

Graphical network of the top 20 diseases related to Pdgfrb-Associated Chronic Eosinophilic Leukemia:



Diseases related to Pdgfrb-Associated Chronic Eosinophilic Leukemia

Symptoms & Phenotypes for Pdgfrb-Associated Chronic Eosinophilic Leukemia

UMLS symptoms related to Pdgfrb-Associated Chronic Eosinophilic Leukemia:


night sweats, fever, fatigue

Drugs & Therapeutics for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Search Clinical Trials , NIH Clinical Center for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Genetic Tests for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Anatomical Context for Pdgfrb-Associated Chronic Eosinophilic Leukemia

MalaCards organs/tissues related to Pdgfrb-Associated Chronic Eosinophilic Leukemia:

38
Neutrophil, Myeloid, Skin, Liver, Spleen

Publications for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Articles related to Pdgfrb-Associated Chronic Eosinophilic Leukemia:

(show top 50) (show all 548)
# Title Authors Year
1
A new approach for diagnosing chronic myelomonocytic leukemia using structural parameters of Sysmex XN<sup>TM</sup>analyzers in routine laboratory practice. ( 29310473 )
2018
2
KIT D816V- chronic myelomonocytic leukemia progressing to KIT D816V+ associated to mast cell leukemia responding to allogeneic hematopoietic cell transplantation. ( 29151134 )
2018
3
Leukemia cutis in a patient with chronic myelomonocytic leukemia. ( 29288601 )
2018
4
EZH2 mutations in chronic myelomonocytic leukemia cluster with ASXL1 mutations and their co-occurrence is prognostically detrimental. ( 29358618 )
2018
5
Retroperitoneal fibrosis as extramedullary hematopoiesis of a chronic myelomonocytic leukemia. ( 29368535 )
2018
6
Chronic myelomonocytic leukemia with central nervous system involvement. ( 29322838 )
2018
7
Overexpression of Arginase 1 is linked to DNMT3A and TET2 mutations in lower-grade myelodysplastic syndromes and chronic myelomonocytic leukemia. ( 29227812 )
2018
8
DNA methylation profile in chronic myelomonocytic leukemia associates with distinct clinical, biological and genetic features. ( 29160764 )
2018
9
Favorable evolution of lung interstitial disease in a patient with chronic myelomonocytic leukemia treated with azacitidine. ( 29170809 )
2018
10
Blastic Transformation in Mexican Population With Chronic Myelomonocytic Leukemia. ( 28842140 )
2017
11
Current management of patients with chronic myelomonocytic leukemia. ( 27849645 )
2017
12
Oligomonocytic chronic myelomonocytic leukemia (chronic myelomonocytic leukemia without absolute monocytosis) displays a similar clinicopathologic and mutational profile to classical chronic myelomonocytic leukemia. ( 28548124 )
2017
13
Posttransplantation relapse of pediatric chronic myelomonocytic leukemia cured using donor lymphocyte infusion. ( 28895279 )
2017
14
Prognostic Impact of Donor Source on Allogeneic Hematopoietic Stem Cell Transplantation Outcomes in Adults with Chronic Myelomonocytic Leukemia: A Nationwide Retrospective Analysis in Japan. ( 29196081 )
2017
15
Adult chronic myelomonocytic leukemia with trisomy 11: a case report. ( 29270065 )
2017
16
Eosinophil-rich tissue infiltrates in chronic myelomonocytic leukemia patients. ( 28593791 )
2017
17
High sensitivity of the Hematoflowa8c solution for chronic myelomonocytic leukemia screening. ( 29108126 )
2017
18
Nucleophosmin 1 (NPM1) mutations in chronic myelomonocytic leukemia and their prognostic relevance. ( 28707414 )
2017
19
How I treat chronic myelomonocytic leukemia. ( 28572287 )
2017
20
Myeloid neoplasms with features intermediate between primary myelofibrosis and chronic myelomonocytic leukemia. ( 29192651 )
2017
21
Successful eltrombopag treatment of severe refractory thrombocytopenia in chronic myelomonocytic leukemia: Two cases reports: A CARE-compliant article. ( 29069007 )
2017
22
Flow cytometry based monocyte subset analysis accurately distinguishes chronic myelomonocytic leukemia from myeloproliferative neoplasms with associated monocytosis. ( 28731458 )
2017
23
A Rare Case of Paraneoplastic Aortitis Associated with Chronic Myelomonocytic Leukemia. ( 28630775 )
2017
24
Clinical and biological significance of isolated Y chromosome loss in myelodysplastic syndromes and chronic myelomonocytic leukemia. A report from the Spanish MDS Group. ( 29121539 )
2017
25
Validation of response assessment according to international consortium for MDS/MPN criteria in chronic myelomonocytic leukemia treated with hypomethylating agents. ( 28498370 )
2017
26
Clinical significance of CSF3R, SRSF2 and SETBP1 mutations in chronic neutrophilic leukemia and chronic myelomonocytic leukemia. ( 28209919 )
2017
27
A phase I study of lenalidomide in patients with chronic myelomonocytic leukemia (CMML) - AGMT_CMML-1. ( 28853315 )
2017
28
A phase II, multicentre trial of decitabine in higher-risk chronic myelomonocytic leukemia. ( 28607470 )
2017
29
Advanced chronic myelomonocytic leukemia in elderly and frail patients managed by azacitidine in the field of clinical practice. ( 28702776 )
2017
30
Generalized palisaded neutrophilic and granulomatous dermatitis-a cutaneous manifestation of chronic myelomonocytic leukemia? A clinical, histopathological, and molecular study of 3 cases. ( 28442268 )
2017
31
Exuberant nodal proliferation of mature plasmacytoid dendritic cells in a patient with chronic myelomonocytic leukemia. ( 28912296 )
2017
32
Engraftment of chronic myelomonocytic leukemia cells in immunocompromised mice supports disease dependency on cytokines. ( 29296739 )
2017
33
Cytogenetic risk stratification may predict allogeneic hematopoietic stem cell transplantation outcomes for chronic myelomonocytic leukemia. ( 29032731 )
2017
34
Bone marrow fibrosis in chronic myelomonocytic leukemia is associated with increased megakaryopoiesis, splenomegaly and with a shorter median time to disease progression. ( 29262560 )
2017
35
DNMT3A mutations are associated with inferior overall and leukemia-free survival in chronic myelomonocytic leukemia. ( 27733013 )
2017
36
Models of Prognostication in Chronic Myelomonocytic Leukemia. ( 29064026 )
2017
37
Aleukemic mast cell leukemia associated with chronic myelomonocytic leukemia and chronic lymphocytic leukemia. ( 29122774 )
2017
38
Mutated ASXL1 and number of somatic mutations as possible indicators of progression to chronic myelomonocytic leukemia of myelodysplastic syndromes with single or multilineage dysplasia. ( 28522578 )
2017
39
Genomic determinants of chronic myelomonocytic leukemia. ( 28555081 )
2017
40
Phase I study of panobinostat and 5-azacitidine in Japanese patients with myelodysplastic syndrome or chronic myelomonocytic leukemia. ( 28905323 )
2017
41
Chronic myelomonocytic leukemia masquerading as cutaneous indeterminate dendritic cell tumor: Expanding the spectrum of skin lesions in chronic myelomonocytic leukemia. ( 28885734 )
2017
42
Prognostic significance of SETBP1 mutations in myelodysplastic syndromes, chronic myelomonocytic leukemia, and chronic neutrophilic leukemia: A meta-analysis. ( 28158286 )
2017
43
Hypomethylating agent therapy use and survival in older patients with chronic myelomonocytic leukemia in the United States: A large population-based study. ( 28621841 )
2017
44
Randomized Phase II Study of Azacitidine Alone or in Combination With Lenalidomide or With Vorinostat in Higher-Risk Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia: North American Intergroup Study SWOG S1117. ( 28486043 )
2017
45
Eltrombopag Use in Patients With Chronic Myelomonocytic Leukemia (CMML): A Cautionary Tale. ( 27521328 )
2016
46
Chronic myelomonocytic leukemia patients with RAS pathway mutations show high in vitro myeloid colony formation in the absence of exogenous growth factors. ( 27585952 )
2016
47
Age-related mutations and chronic myelomonocytic leukemia. ( 26648538 )
2016
48
Autoimmune and inflammatory diseases associated with chronic myelomonocytic leukemia: A series of 26 cases and literature review. ( 27337291 )
2016
49
Chronic myelomonocytic leukemia mimicking hematologic systemic lupus erythematosus. ( 27365372 )
2016
50
Integrating clinical features and genetic lesions in the risk assessment of patients with chronic myelomonocytic leukemia. ( 27385790 )
2016

Variations for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Expression for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Search GEO for disease gene expression data for Pdgfrb-Associated Chronic Eosinophilic Leukemia.

Pathways for Pdgfrb-Associated Chronic Eosinophilic Leukemia

GO Terms for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Sources for Pdgfrb-Associated Chronic Eosinophilic Leukemia

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