MCID: PDG002
MIFTS: 16

Pdgfrb-Associated Chronic Eosinophilic Leukemia

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Pdgfrb-Associated Chronic Eosinophilic Leukemia

MalaCards integrated aliases for Pdgfrb-Associated Chronic Eosinophilic Leukemia:

Name: Pdgfrb-Associated Chronic Eosinophilic Leukemia 50 25 69
Atypical Philadelphia-Negative Chronic Myeloid Leukemia 50 25
Primary Eosinophilia with Chronic Myeloproliferative Disorder 25
Clonal Eosinophilia with Chronic Myeloproliferative Disorder 25
Chronic Myeloproliferative Disorder with Eosinophilia 25
Leukemia, Myelomonocytic, Chronic 69
Chronic Myelomonocytic Leukemia 25

Classifications:



Summaries for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Genetics Home Reference : 25 PDGFRB-associated chronic eosinophilic leukemia is a type of cancer of blood-forming cells. It is characterized by an elevated number of white blood cells called eosinophils in the blood. These cells help fight infections by certain parasites and are involved in the inflammation associated with allergic reactions. However, these circumstances do not account for the increased number of eosinophils in PDGFRB-associated chronic eosinophilic leukemia. Some people with this condition have an increased number of other types of white blood cells, such as neutrophils or mast cells, in addition to eosinophils. People with this condition can have an enlarged spleen (splenomegaly) or enlarged liver (hepatomegaly). Some affected individuals develop skin rashes, likely as a result of an abnormal immune response due to the increased number of eosinophils.

MalaCards based summary : Pdgfrb-Associated Chronic Eosinophilic Leukemia, also known as atypical philadelphia-negative chronic myeloid leukemia, is related to chronic myelomonocytic leukemia and juvenile myelomonocytic leukemia, and has symptoms including fatigue, fever and night sweats. Affiliated tissues include neutrophil, myeloid and skin.

Related Diseases for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Diseases related to Pdgfrb-Associated Chronic Eosinophilic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
id Related Disease Score Top Affiliating Genes
1 chronic myelomonocytic leukemia 12.4
2 juvenile myelomonocytic leukemia 11.9
3 myelodysplastic syndrome 11.4
4 leukemia 11.0
5 myelodysplastic myeloproliferative cancer 11.0
6 myeloid leukemia 10.4
7 systemic mastocytosis 10.1
8 refractory anemia 10.1
9 atypical chronic myeloid leukemia 10.1
10 chronic neutrophilic leukemia 10.1
11 myeloproliferative neoplasm 10.1
12 acute leukemia 10.0
13 thrombocytopenia 10.0
14 multiple myeloma 10.0
15 chronic lymphocytic leukemia 10.0
16 lymphoma 10.0
17 lymphoblastic leukemia 10.0
18 sarcoma 10.0
19 hematopoietic stem cell transplantation 9.9
20 purpura 9.9
21 histiocytosis 9.9
22 vasculitis 9.9
23 pericardial effusion 9.8
24 polyneuropathy 9.8
25 dermatitis 9.8
26 antiphospholipid syndrome 9.8
27 pyoderma 9.8
28 aortitis 9.8
29 monocytic leukemia 9.8
30 pyoderma gangrenosum 9.8
31 chronic graft versus host disease 9.8
32 dendritic cell tumor 9.8
33 generalized eruptive histiocytosis 9.8
34 porphyria cutanea tarda 9.7
35 systemic lupus erythematosus 9.7
36 pyruvate kinase deficiency 9.7
37 hepatocellular carcinoma 9.7
38 breast cancer 9.7
39 aplastic anemia 9.7
40 mast cell disease 9.7
41 burkitt lymphoma 9.7
42 keratitis 9.7
43 myeloperoxidase deficiency 9.7
44 ewing sarcoma 9.7
45 temporal arteritis 9.7
46 acute monocytic leukemia 9.7
47 chronic inflammatory demyelinating polyneuropathy 9.7
48 granuloma annulare 9.7
49 liver disease 9.7
50 myasthenia gravis 9.7

Graphical network of the top 20 diseases related to Pdgfrb-Associated Chronic Eosinophilic Leukemia:



Diseases related to Pdgfrb-Associated Chronic Eosinophilic Leukemia

Symptoms & Phenotypes for Pdgfrb-Associated Chronic Eosinophilic Leukemia

UMLS symptoms related to Pdgfrb-Associated Chronic Eosinophilic Leukemia:


fatigue, fever, night sweats

Drugs & Therapeutics for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Search Clinical Trials , NIH Clinical Center for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Genetic Tests for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Anatomical Context for Pdgfrb-Associated Chronic Eosinophilic Leukemia

MalaCards organs/tissues related to Pdgfrb-Associated Chronic Eosinophilic Leukemia:

39
Neutrophil, Myeloid, Skin, Liver, Spleen

Publications for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Variations for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Expression for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Search GEO for disease gene expression data for Pdgfrb-Associated Chronic Eosinophilic Leukemia.

Pathways for Pdgfrb-Associated Chronic Eosinophilic Leukemia

GO Terms for Pdgfrb-Associated Chronic Eosinophilic Leukemia

Sources for Pdgfrb-Associated Chronic Eosinophilic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....