MCID: PCT001
MIFTS: 27

Pectus Carinatum

Categories: Rare diseases

Aliases & Classifications for Pectus Carinatum

Summaries for Pectus Carinatum

NIH Rare Diseases : 49 Pectus carinatum refers to a chest wall abnormality in which the breastbone is pushed outward. It generally presents during childhood and worsens through adolescence. If the condition occurs in isolation, it is often not associated with any additional signs or symptoms. Rarely, affected people report shortness of breath during exercise, frequent respiratory infections, and/or asthma. The underlying cause of isolated pectus carinatum is unknown. Pectus carinatum can also be associated with a variety of genetic disorders and syndromes, including Marfan syndrome, Noonan syndrome, Morquio syndrome, homocystinuria, osteogenesis imperfecta, Coffin-Lowery syndrome, cardiofaciocutaneous syndrome, and certain chromosome abnormalities. In these cases, the condition has an underlying genetic cause and is associated with additional features that are characteristic of the genetic disease. Pectus carinatum is primarily a cosmetic concern and treatment, therefore, depends on the severity of the condition and the interests of the affected person and their family. In those who choose to pursue treatment, bracing and/or surgery may be an option. Last updated: 4/10/2016

MalaCards based summary : Pectus Carinatum, also known as carinatum deformity of the chest, is related to guizar vasquez sanchez manzano syndrome and spondyloepimetaphyseal dysplasia, strudwick type. An important gene associated with Pectus Carinatum is COL2A1 (Collagen Type II Alpha 1 Chain). The drugs Ethanol and Zinc have been mentioned in the context of this disorder. Affiliated tissues include breast.

Wikipedia : 72 Pectus carinatum (L carīnātus, equiv. to carīn(a) keel), also called pigeon chest, is a malformation of... more...

Related Diseases for Pectus Carinatum

Graphical network of the top 20 diseases related to Pectus Carinatum:



Diseases related to Pectus Carinatum

Symptoms & Phenotypes for Pectus Carinatum

Drugs & Therapeutics for Pectus Carinatum

Drugs for Pectus Carinatum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved 64-17-5 702
2
Zinc Approved, Investigational 7440-66-6 32051 23994
3
Loperamide Approved 53179-11-6 3955
4
Epinephrine Approved, Vet_approved 51-43-4 5816
5
Hydrocortisone Approved, Vet_approved 50-23-7 657311 5754
6 Racepinephrine Approved 329-65-7
7
Caffeine Approved, Nutraceutical 58-08-2 2519
8 insulin
9 Hypoglycemic Agents
10 Pharmaceutical Solutions
11 Insulin, Globin Zinc
12 Gastrointestinal Agents
13 Cortisol succinate
14 Hydrocortisone 17-butyrate 21-propionate
15 Hydrocortisone acetate
16 Epinephryl borate
17 Antidiarrheals
18 Locust bean gum
19 histidine Nutraceutical

Interventional clinical trials:

(show all 11)

# Name Status NCT ID Phase Drugs
1 The Role of Meat-borne Carcinogens in Pancreatic Cancer Withdrawn NCT01092689 Phase 1 PhiP
2 Short and Long-term Effects of Surgical Repair of Pectus Deformities Unknown status NCT01329120
3 Determination of Glycemic and Insulinemic Indices Unknown status NCT01477216
4 Health-related Quality of Life in Patients Undergoing Surgery for Pectus Carinatum Completed NCT01692392
5 Pharmacokinetics of Carnosine Completed NCT00721708
6 Study of Cushing's Syndrome Not Related to ACTH Production Completed NCT00006278
7 Short-term Effects of a Carob Snack on Postprandial Glycemic Responses and Energy Intake and Satiety Completed NCT02935829
8 Physiological Assessments During Non Operative Treatment on the Chest Wall Deformities Recruiting NCT02528656
9 Chest Wall Motion Analysis in Disease Recruiting NCT02958683
10 Impact of Surgical Treatments of Thoracic Deformation on Cardiopulmonary Functions Active, not recruiting NCT02163265
11 The Metabolic Effects of Consuming Carbohydrate With Different Protein Types Active, not recruiting NCT02380846

Search NIH Clinical Center for Pectus Carinatum

Genetic Tests for Pectus Carinatum

Genetic tests related to Pectus Carinatum:

# Genetic test Affiliating Genes
1 Pectus Carinatum 28

Anatomical Context for Pectus Carinatum

MalaCards organs/tissues related to Pectus Carinatum:

38
Breast

Publications for Pectus Carinatum

Articles related to Pectus Carinatum:

(show top 50) (show all 118)
# Title Authors Year
1
Minimally Invasive Repair of Pectus Carinatum. ( 29325984 )
2018
2
The effect on cardiopulmonary function after thoracoplasty in pectus carinatum: a systematic literature review. ( 29092017 )
2018
3
Pain and sensory disturbances following surgical repair of pectus carinatum. ( 28893382 )
2017
4
Success and duration of dynamic bracing for pectus carinatum: A four-year prospective study. ( 27836367 )
2017
5
The Dynamic Compression Brace for Pectus Carinatum: Intermediate Results in 286 Patients. ( 28274516 )
2017
6
Force required for correcting the deformity of pectus carinatum and related multivariate analysis. ( 29357992 )
2017
7
Psychosocial functioning in pediatric patients with pectus excavatum and pectus carinatum. ( 28618768 )
2017
8
A Single-Center Experience with Dynamic Compression Bracing for Children with Pectus Carinatum. ( 28946165 )
2017
9
Visual Diagnosis: A Child with Presumed Reactive Airway Disease, Pectus Carinatum, and Aortic Root Dilation. ( 28044041 )
2017
10
A less intensive bracing protocol for pectus carinatum. ( 28196662 )
2017
11
Minimally invasive repair of pectus carinatum and how to deal with complications. ( 29078492 )
2016
12
Induced Pectus Carinatum. ( 26989996 )
2016
13
The sandwich technique for repair of pectus carinatum and excavatum/carinatum complex. ( 27747176 )
2016
14
MyPectus: First-in-human pilot study of remote compliance monitoring of teens using dynamic compression bracing to correct pectus carinatum. ( 26700692 )
2016
15
A new technique for mixed-type pectus carinatum: modified Onen method. ( 26758385 )
2016
16
Anaesthetic Management of Laparoscopic Morgagni Hernia Repair in a Patient with Coexisting Down Syndrome, Patent Foramen Ovale and Pectus Carinatum. ( 27366555 )
2016
17
Minimally Invasive Repair of Pectus Carinatum in Patients Unsuited to Bracing Therapy. ( 27066432 )
2016
18
Dynamic Compression System: An Effective Nonoperative Treatment for Pectus Carinatum: A Single Center Experience in Basel, Switzerland. ( 26745521 )
2016
19
Non-surgical treatment of pectus carinatum with the FMF<sup>Ar</sup>Dynamic Compressor System. ( 29078485 )
2016
20
Complications Related to Pectus Carinatum Correction: Lessons Learned from 15 Years' Experience. Management and Literature Review. ( 27465193 )
2016
21
PECTUS CARINATUM: A NOVEL METHOD OF STERNAL FIXATION. ( 28850201 )
2016
22
Clinical experience with orthotic repair of pectus carinatum. ( 26922690 )
2016
23
Is the Abramson technique effective in pectus carinatum repair? ( 27825548 )
2016
24
Pectus carinatum repair in an adolescent with hyperhomocysteinaemia: Anaesthetic implications. ( 27942072 )
2016
25
Pectus Excavatum and Pectus Carinatum: Associated Conditions, Family History, and Postoperative Patient Satisfaction. ( 26889443 )
2016
26
Sparing internal thoracic vessels in thoracoscopic or submuscular correction of pectus carinatum: A porcine model study. ( 26362004 )
2015
27
Pectus Carinatum Evaluation Questionnaire (PCEQ): a novel tool to improve the follow-up in patients treated with brace compression. ( 26059874 )
2015
28
The etiology of pectus carinatum involves overgrowth of costal cartilage and undergrowth of ribs. ( 25092085 )
2014
29
Highly Efficient Conservative Treatment of Pectus Carinatum in Compliant Patients. ( 25111271 )
2014
30
Unusual feature of pycnodysostosis: pectus carinatum. ( 24938251 )
2014
31
Finite element analysis of pectus carinatum surgical correction via a minimally invasive approach. ( 24428546 )
2014
32
Plummer-Vinson syndrome with pectus carinatum mitral valve prolapsus and exotropia in an 18-year-old boy. ( 24451233 )
2014
33
Factors affecting patient compliance with compressive brace therapy for pectus carinatum. ( 25164133 )
2014
34
Surgical correction of pectus carinatum improves perceived body image, mental health and self-esteem. ( 25783317 )
2014
35
Pure pectus carinatum (not associated with pectus excavatum) solved by MIRPC (minimally invasive repair of pectus carinatum) associated with bilateral mamarian hypoplasia solved by bilateral breast implants. ( 24524485 )
2014
36
Redo cardiac surgery in a patient with severe kyphoscoliosis and pectus carinatum: a technical challenge. ( 25146320 )
2014
37
Evaluation of the treatment of pectus carinatum with compressive orthotic bracing using three dimensional body scans. ( 24888836 )
2014
38
Minimal invasive extrathoracic presternal compression using a metal bar for correction of pectus carinatum. ( 24096528 )
2014
39
Pectus carinatum: the effects of orthotic bracing on pulmonary function and gradual compression on patient compliance. ( 23824936 )
2013
40
Mandibulofacial dysostosis (Treacher-Collins syndrome) in the fetus: Novel association with pectus carinatum in a molecularly confirmed case and review of the fetal phenotype. ( 24288143 )
2013
41
Bracing is an effective therapy for pectus carinatum: interim results. ( 23331813 )
2013
42
Does overgrowth of costal cartilage cause pectus carinatum? A three-dimensional computed tomography evaluation of rib length and costal cartilage length in patients with asymmetric pectus carinatum. ( 23868604 )
2013
43
Straightened sternal wire causes iatrogenic pectus carinatum after cardiac surgery. ( 22576764 )
2013
44
Staged management of pectus carinatum. ( 23414858 )
2013
45
The Nuss operation for pectus carinatum. ( 22700594 )
2013
46
Quality of life of patients who have undergone the minimally invasive repair of pectus carinatum. ( 22491695 )
2013
47
Pectus carinatum. ( 23657247 )
2013
48
Bracing in pediatric patients with pectus carinatum is effective and improves quality of life. ( 23701782 )
2013
49
Sub-axillary access with the use of costal cartilages articulated bars for correction of pectus carinatum. ( 23111343 )
2013
50
Chondro-manubrial deformity and bifid rib, rare variations seen in pectus carinatum: a radiological finding. ( 23196368 )
2013

Variations for Pectus Carinatum

Expression for Pectus Carinatum

Search GEO for disease gene expression data for Pectus Carinatum.

Pathways for Pectus Carinatum

GO Terms for Pectus Carinatum

Sources for Pectus Carinatum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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