Pediatric Crohns Disease malady

NIH Rare Diseases: Crohn's disease is a type of inflammatory bowel disease (IBD), the general name for conditions that cause inflammation in the intestines. Common signs and symptoms include abdominal pain and diarrhea. Bleeding from the rectum, weight loss, joint pain, skin problems and fever may also occur. Other problems can include intestinal blockage and malnutrition. Crohn's disease can occur in people of all age groups but is most often diagnosed in young adults. The exact cause is unknown, but is thought to involve both genetic and environmental factors. It appears to run in some families. Treatment is aimed at relieving symptoms and reducing inflammation, but some people require surgery. Quitting smoking can also improve the symptoms of Crohn’s disease.³⁰

MalaCards: Pediatric Crohns Disease, also known as pediatric onset crohns disease, is related to crohn's disease and granulomatous dermatitis. An important gene associated with Pediatric Crohns Disease is CENPW (centromere protein W), and among its related pathways are Bacterial infections in CF airways and Pathways in cancer. The compounds endotoxin and ionomycin have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are liver/biliary system and endocrine/exocrine gland.

pediatric crohns disease 30 pediatric onset crohns disease 30

crohns disease, pediatric 30 pediatric crohn's disease 43

Diseases related to pediatric crohns disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 401)

id	Related Disease	Score	Top Affiliating Genes
1	crohn's disease	28.8	LBP, IL10, IL1B, TNF, PPARG, NOD2
2	granulomatous dermatitis	13.3	TNF, NOD2
3	clostridium sordellii	13.2	TNF, PTGER4
4	erythema nodosum, idiopathic	13.2	TNF, NOD2
5	insulin-like growth factor i deficiency	13.1	IGF1, STAT5B
6	punctate inner choroidopathy	13.0	IL10, TNF
7	ankylosing spondylitis	12.9	TNF, TNFSF11, NOD2
8	pyoderma	12.9	ALB, TNF, NOD2
9	alcoholic hepatitis	12.9	LBP, ALB, TNF
10	lipoid nephrosis	12.9	IL10, ALB
11	central nervous system leukemia	12.9	IL1B, TNF
12	iron deficiency anemia	12.8	ALB, TNF, SLC40A1
13	fissured tongue	12.8	IL1B, TNF
14	panuveitis	12.8	IL10, TNF
15	sepsis	12.8	IL10, TNF
16	spotted fever	12.8	IL10, TNF, CXCL9
17	paratyphoid fever	12.8	IL1B, TNF, HIST1H1D
18	viral encephalitis	12.7	IL10, IL1B, CXCL9
19	extrapulmonary tuberculosis	12.7	IL10, IL1B, CXCL9
20	t-cell large granular lymphocyte leukemia	12.7	IL10, IL15, TNF
21	staphylococcal toxic shock syndrome	12.7	IL1B, TNF
22	endotoxin hyporesponsiveness	12.7	IL1B, TNF
23	acute graft versus host disease	12.6	IL10, IL15, TNF, NOD2
24	cardiac sarcoidosis	12.6	IL15, IL1B, TNF
25	pulmonary plasma cell granuloma	12.6	IL10, IL15, TNF, NOD2
26	achalasia	12.6	IL10, IL23R, TNF
27	large granular lymphocyte leukemia	12.6	IL10, IL15, TNF
28	arthritis	12.5	IL1B, TNF, TNFSF11
29	placental choriocarcinoma	12.5	ALB, PPARG, SLC22A5
30	myelofibrosis	12.5	IL15, TNF, TNFSF11, STAT5B
31	melioidosis	12.5	IL10, IL15, IL1B, CXCL9
32	intracranial hypertension	12.5	IL1B, ALB, TNF
33	autoimmune pancreatitis	12.5	IL10, ALB, TNF
34	monoclonal gammopathy of undetermined significance	12.5	IL1B, IGF1, TNFSF11
35	obstructive jaundice	12.5	LBP, IGF1, ALB, TNF
36	psoriatic arthritis	12.5	IL1B, TNF, TNFSF11, NOD2
37	paracoccidioidomycosis	12.5	IL10, ALB, TNF, CXCL9
38	demyelinating polyneuropathy	12.5	IL10, ALB, TNF, CXCL9
39	cork-handlers' disease	12.4	IGF1, ALB, TNF, CXCL9
40	mycobacterial infection	12.4	IL10, IL15, TNF
41	hemochromatosis	12.4	IGF1, ALB, TNF, NOD2, SLC40A1
42	tuberculous meningitis	12.4	IL10, IL1B, TNF
43	aseptic meningitis	12.4	IL10, IL1B, TNF
44	pericarditis	12.4	IL1B, ALB, TNF
45	pulmonary function	12.4	IL10, ALB, TNF, HHIP
46	classic kaposi sarcoma	12.4	IL10, IL1B, TNF
47	acrodermatitis	12.4	IL1B, ALB, TNF, CXCL9
48	intrauterine infections	12.4	IL10, IL1B, TNF
49	keratomalacia	12.4	IL10, IGF1, ALB
50	hemorrhagic fever with renal syndrome	12.4	IL10, IGF1, TNF

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to pediatric crohns disease:

²²

MGI Mouse Phenotypes related to pediatric crohns disease:

²⁵ (show all 17)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system phenotype	MP:0005370	10.1	SLC22A5, SLC40A1, LBP, EFEMP1
2	endocrine/exocrine gland phenotype	MP:0005379	9.9	HHIP, CDK6, ATG16L1
3	digestive/alimentary phenotype	MP:0005381	9.7	NOD2, EFEMP1, HHIP, ATG16L1, SLC40A1, IHH
4	integument phenotype	MP:0010771	9.6	TNFSF11, SLC40A1, EFEMP1, PTGER4
5	hematopoietic system phenotype	MP:0005397	9.0	NOD2, HHIP, EFEMP1, SLC40A1, HIST1H1D, PTGER4
6	skeleton phenotype	MP:0005390	8.7	IGF1, NFKB1, NOD2, PPARG, TNFSF11
7	growth/size phenotype	MP:0005378	8.1	CDK6, HHIP, EFEMP1, SLC22A5, PAX5, SLC40A1
8	immune system phenotype	MP:0005387	8.1	IL23R, PAX5, LBP, CDK6, HHIP, SLC40A1
9	reproductive system phenotype	MP:0005389	7.7	HIST1H1D, STAT5B, EFEMP1, IL15, IL10, TNFSF11
10	respiratory system phenotype	MP:0005388	7.3	STAT5B, HHIP, TNF, PHOX2B, PTGER4, IGF1
11	tumorigenesis	MP:0002006	6.9	IL10, CDK6, STAT5B, IL1B, IGF1, PPARG
12	muscle phenotype	MP:0005369	6.8	EFEMP1, NFKB1, PPARG, IGF1, IHH, IL10
13	normal phenotype	MP:0002873	6.6	PTGER4, PPARG, PHOX2B, NFKB1, HIST1H1D, STAT5B
14	mortality/aging	MP:0010768	6.3	PPARG, BSN, PAX5, ATG16L1, CDK6, IL15
15	cardiovascular system phenotype	MP:0005385	6.3	PHOX2B, CDK6, IL10, IL1B, EFEMP1, HIST1H1D
16	homeostasis/metabolism phenotype	MP:0005376	5.1	PHOX2B, LBP, IL10, IL1B, IL23R, IGF1
17	cellular phenotype	MP:0005384	5.0	HHIP, STAT5B, NFKB1, PHOX2B, NOD2, PPARG

Articles related to pediatric crohns disease:

(show all 19)

id	Title	Authors	Year	Affiliating Genes
1	Osteoprotegerin in pediatric Crohn's disease and the effects of exclusive enteral nutrition. (20848544)	Nahidi L.... Day A.S.	2011	TNFSF11
2	Intestinal ferroportin expression in pediatric Crohn' s disease. (20564534)	Burpee T.... Grand R.J.	2011	SLC40A1
3	Lipopolysaccharide exposure is linked to activation o f the acute phase response and growth failure in pediatric Crohn's disease and murine colitis. (19924809)	Pasternak B.A.... Denson L.A.	2010	LBP, IL10
4	Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study. (20846217)	Lee J.J.... Hirschhorn J.	2010	CDK6, EFEMP1, IHH
5	Mechanisms of growth impairment in pediatric Crohn's disease. (19713986)	Walters T.D.... Griffiths A.M.	2009	IGF1
6	Effects of infliximab and parenteral nutrition on albumin and fibrinogen synthesis rates in pediatric Crohn disease. (18979581)	Steiner S.J.... Denne S.C.	2008	ALB
7	Improvement in biomarkers of bone formation during infliximab therapy in pediatric Crohn's disease: results of the REACH study. (19081527)	Thayu M.... Baldassano R.N.	2008	PAX5
8	Mucosal NOD2 expression and NF-kappaB activation in pediatric Crohn's disease. (18092345)	Stronati L.... Cucchiara S.	2008	NFKB1, TNF, IL1B
9	Association of variants of the interleukin-23 receptor gene with susceptibility to pediatric Crohn's disease. (17618837)	Baldassano R.N.... Hakonarson H.	2007	NOD2, IL23R
10	IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease. (17309073)	Dubinsky M.C.... Rotter J.I.	2007	IL23R
11	Association of a CXCL9 polymorphism with pediatric Crohn's disease. (17892861)	Lacher M.... Koletzko S.	2007	CXCL9
12	Clinical and biological consequences of immunization to infliximab in pediatric Crohn's disease. (16125467)	Candon S.... CAczard J.P.	2006	TNF
13	Signal transducer and activator of transcription 5b promotes mucosal tolerance in pediatric Crohn's disease and murine colitis. (17148664)	Han X.... Denson L.A.	2006	PPARG, STAT5B
14	CARD15 mutations are rare in Swedish pediatric Crohn disease. (15795594)	Idestrom M.... Hugot J.P.	2005	NOD2
15	Ileal involvement is age dependent in pediatric Crohn's disease. (15973117)	Meinzer U.... Hugot J.P.	2005	NOD2
16	TNF promoter polymorphisms and modulation of growth retardation and disease severity in pediatric Crohn's disease. (15984988)	Levine A.... Leshinsky-Silver E.	2005	TNF, NOD2
17	CDP571, a humanized anti-tumor necrosis factor-alpha monoclonal antibody in pediatric Crohn's disease. (15626889)	Mamula P.... Baldassano R.N.	2004	TNF
18	Pediatric Crohn's disease and growth retardation: the role of genotype, phenotype, and disease severity. (15520108)	Wine E.... Levine A.	2004	NOD2
19	Cytokine tissue levels as markers of disease activity in pediatric Crohn disease. (12840152)	Silva M.A.... Seidman E.G.	2003	IL15

Genes related to pediatric crohns disease according to GeneCards:

(show all 35)

id	Symbol	Description	Score	GeneCards Section Context
1	CENPW	centromere protein W	11.0	Publications
2	ANAPC13	anaphase promoting complex subunit 13	11.0	Publications
3	HIST1H1D	histone cluster 1, H1d	11.0	Publications
4	IHH	Indian hedgehog	11.0	Publications
5	PHOX2B	paired-like homeobox 2b	11.0	Publications
6	NOD2	nucleotide-binding oligomerization domain containing 2	11.0	Publications
7	EFEMP1	EGF containing fibulin-like extracellular matrix protein 1	11.0	Publications
8	SLC22A4	solute carrier family 22 (organic cation/ergothioneine transporter), member 4	11.0	Publications
9	CEP63	centrosomal protein 63kDa	11.0	Publications
10	SLC40A1	solute carrier family 40 (iron-regulated transporter), member 1	11.0	Publications
11	LIN28B	lin-28 homolog B (C. elegans)	11.0	Publications
12	LBP	lipopolysaccharide binding protein	11.0	Publications
13	PTGER4	prostaglandin E receptor 4 (subtype EP4)	11.0	Publications
14	ZNF678	zinc finger protein 678	11.0	Publications
15	SLC22A5	solute carrier family 22 (organic cation/carnitine transporter), member 5	11.0	Publications
16	ZBTB38	zinc finger and BTB domain containing 38	11.0	Publications
17	C6orf106	chromosome 6 open reading frame 106	11.0	Publications
18	CXCL9	chemokine (C-X-C motif) ligand 9	11.0	Publications
19	HHIP	hedgehog interacting protein	11.0	Publications
20	BSN	bassoon (presynaptic cytomatrix protein)	11.0	Publications
21	ATG16L1	autophagy related 16-like 1 (S. cerevisiae)	11.0	Publications
22	SPAG17	sperm associated antigen 17	11.0	Publications
23	STAT5B	signal transducer and activator of transcription 5B	11.0	Publications
24	IL23R	interleukin 23 receptor	11.0	Publications
25	IL15	interleukin 15	11.0	Publications
26	TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	11.0	Publications
27	CDK6	cyclin-dependent kinase 6	11.0	Publications
28	PAX5	paired box 5	11.0	Publications
29	NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	11.0	Publications
30	IL1B	interleukin 1, beta	11.0	Publications
31	ALB	albumin	11.0	Publications
32	TNF	tumor necrosis factor	11.0	Publications
33	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications
34	IL10	interleukin 10	11.0	Publications
35	PPARG	peroxisome proliferator-activated receptor gamma	11.0	Publications

Pathways related to pediatric crohns disease according to GeneDecks:

(show all 49)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways41	10.7	LBP
2	Pathways in cancer20	10.6	HHIP
3	RAR-Gamma-RXR-Alpha Degradation36	10.4	CXCL9, IL15
4	Immune response_IL-23 signaling pathway41	10.4	STAT5B
5	Organic cation transport38	10.2	SLC22A5, SLC22A4
6	Amoebiasis20	10.2	IL1B
7	Immune response IL-23 signaling pathway10	9.8	NFKB1, STAT5B, IL23R
8	IL-9 Pathway36	9.6	TNF, NFKB1, STAT5B
9	Molecular Mechanisms of Cancer36	9.6	IL23R, IL15, EFEMP1, CXCL9, TNFSF11, IHH
10	IL-6 Pathway36	9.6	IL10, TNFSF11, CXCL9
11	Cytokine production by Th17 cells in CF41	9.6	LBP, IL23R, NFKB1
12	Immune response_MIF in innate immunity response41	9.4	NFKB1, TNF, IL1B, LBP
13	Immune response MIF in innate immunity response10	9.4	TNF, LBP, IL1B, NFKB1
14	NOD-like receptor signaling pathway20	9.4	IL1B, NOD2, TNF, NFKB1
15	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway10	9.3	NFKB1, TNFSF11, TNF
16	Rheumatoid arthritis20	9.2	IL15, IL1B, TNF, TNFSF11
17	Toll-like receptor signaling pathway20	9.2	LBP, IL1B, TNF, NFKB1, CXCL9
18	TRAF Pathway36	9.2	IL1B, TNF, TNFSF11, NFKB1
19	NF-kappaB Signaling3	9.2	NFKB1, TNF, IL1B, TNFSF11
20	Immune response IL-10 signaling pathway10	9.1	IL10, TNF, STAT5B
21	Immune response_IL-10 signaling pathway41	9.1	IL10, TNF, STAT5B
22	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.0	TNFSF11, IL1B, IGF1, TNF
23	Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway41	9.0	NFKB1, TNFSF11, TNF
24	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.0	TNFSF11, TNF, IGF1, IL1B
25	Cytokine Network36	8.9	IL15, TNF, IL1B, IL10
26	IL-10 Pathway36	8.8	IL10, TNF, NFKB1, IL1B
27	Akt Signaling36	8.7	TNF, CXCL9, IL15, IL10, TNFSF11
28	African trypanosomiasis20	8.7	TNF, IL10, IL1B
29	Osteoclast differentiation20	8.7	NFKB1, TNF, PPARG, TNFSF11, IL1B
30	Leishmaniasis20	8.7	NFKB1, TNF, IL1B, IL10
31	Pertussis20	8.7	IL10, IL1B, TNF, NFKB1
32	Glucocorticoid Receptor Signaling36	8.6	IL15, IL1B, IL10, NFKB1, STAT5B
33	Chagas disease (American trypanosomiasis)20	8.5	IL1B, NFKB1, TNF, IL10
34	Tuberculosis20	8.5	NOD2, LBP, NFKB1, IL10, TNF, IL1B
35	all-trans-Retinoic Acid Signaling in Brain36	8.4	CXCL9, TNFSF11, TNF, IL10, IL15, IL1B
36	Endothelin-1 Signaling Pathway36	8.3	IL15, IL1B, IL10, TNF, TNFSF11, CXCL9
37	Tec Kinases Signaling36	8.3	STAT5B, NFKB1, IGF1, IL23R, IL15, IL10
38	STAT3 Pathway36	8.1	IL1B, CXCL9, TNFSF11, TNF, IL23R, IL10
39	Cytokine-cytokine receptor interaction20	8.1	IL15, CXCL9, TNFSF11, TNF, IL23R, IL10
40	MIF Mediated Glucocorticoid Regulation36	8.0	CXCL9, NFKB1, TNFSF11, TNF, IL1B, IL15
41	MIF Regulation of Innate Immune Cells36	8.0	CXCL9, NFKB1, TNF, IL1B, IL15, TNFSF11
42	PEDF Induced Signaling36	8.0	IL10, NFKB1, TNFSF11, TNF, IL1B, IL15
43	JAK-STAT Pathway36	8.0	NFKB1, STAT5B, IGF1, IL1B, IL15, IL10
44	MAPK Family Pathway36	7.7	IL15, IL10, IL1B, IGF1, TNF, NFKB1
45	PAK Pathway36	7.7	TNF, IL10, IL15, IL1B, CXCL9, IGF1
46	Rho Family GTPases36	7.2	CXCL9, TNF, TNFSF11, IL10, IL15, IL1B
47	ERK Signaling36	7.2	NFKB1, TNF, IL1B, IL15, TNFSF11, IGF1
48	Antioxidant Action of Vitamin-C36	7.1	TNF, IL10, IGF1, IL1B, TNFSF11, CXCL9
49	p38 Signaling36	7.1	IL10, NFKB1, TNFSF11, TNF, IGF1, IL23R

Compounds related to pediatric crohns disease according to GeneDecks:

(show top 50)    (show all 63)

id	Compound	Score	Top Affiliating Genes
1	endotoxin32	10.5	CXCL9, LBP
2	ionomycin32	10.3	CDK6
3	rapamycin32 42	11.3	STAT5B, CDK6
4	l-nmma32	10.3	PPARG
5	25-hydroxyvitamin d32	10.2	TNFSF11, PAX5
6	rantes32	10.1	TNFSF11, CXCL9, IL15
7	pge232	9.8	PTGER4, TNFSF11, PPARG
8	leflunomide32 9 9	11.8	IL15, TNFSF11, TNF
9	calcitriol32 42 9 18 9	13.7	LBP, ALB, PAX5, TNFSF11
10	bay 11-708542	9.6	TNF, NFKB1
11	quinine32 9 9	11.5	IL10, CXCL9, SLC22A4, SLC22A5
12	ns 39832 42	10.5	PTGER4, TNFSF11, TNF, IL1B
13	creatinine32	9.3	CXCL9, LBP, IGF1, IL15
14	rituximab32 34 9 9	12.2	IL10, IL15, PAX5
15	blys32	9.2	IL10, TNF, IL15
16	clodronate32 9 9	11.2	IL10, TNFSF11, IL1B
17	naproxen32 9 18 9	12.1	IL1B, IGF1, ALB
18	toxin-132	9.0	IL10, TNF, IL1B
19	lipoteichoic acid32	9.0	LBP, IL10, IL1B, TNF
20	groalpha32	8.9	IL10, CXCL9, TNF, IL1B
21	il-1232	8.9	IL15, TNF, IL1B, IL10
22	mip 1alpha32	8.9	TNF, TNFSF11, IL10, IL1B
23	gm-csf32	8.8	IL1B, IL15, TNF, IL10
24	vegf32	8.8	IGF1, PTGER4, TNFSF11, IL1B, PPARG
25	polyinosinic-polycytidylic acid32	8.8	IL1B, IL15, IL10, TNF
26	sb 20358032 42	9.8	IGF1, TNFSF11, PPARG, TNF
27	polymyxin b32	8.7	LBP, IL10, IL1B, TNF, TNFSF11
28	ccl332	8.7	CXCL9, TNF, IL10, IL15, IL1B
29	5 aminosalicylic acid32	8.6	TNF, IL1B, IL10, PPARG
30	thalidomide32 42 9 9	11.6	IL10, TNF, NFKB1, IL1B
31	ly29400232	8.6	IL10, IL1B, TNF, TNFSF11, STAT5B
32	etanercept32 9 9	10.6	IL15, TNF, TNFSF11, IL10, IL1B
33	ibuprofen32 9 18 9	11.5	IL1B, ALB, PPARG, IL10
34	prostaglandin32	8.5	TNF, TNFSF11, PTGER4, PPARG, IL1B
35	infliximab32 9 9	10.5	IL10, IL15, IL1B, TNF, TNFSF11, NOD2
36	indomethacin32 9 9	10.4	IL1B, PPARG, PTGER4, TNFSF11, TNF, ALB
37	tgf beta132	8.4	CDK6, IL10, IL15, IL1B, TNF
38	il 1032	8.4	IL1B, CXCL9, NOD2, LBP, IL10, IL15
39	15-deoxy-delta-12,14-prostaglandin j232	8.3	IL1B, TNF, PPARG, IL10
40	arachidonic acid32 9 18 9	11.3	PTGER4, TNFSF11, PPARG, TNF, ALB, IL1B
41	peptidoglycan32	8.3	LBP, IL10, IL15, IL1B, TNFSF11, NOD2
42	prostacyclin32	8.2	HHIP, PTGER4, TNF, IL1B, IL10, PPARG
43	hydrocortisone32 9 9	10.2	IL10, IL1B, IGF1, TNF, IL15
44	methotrexate32 34 42 9 9	12.1	IL1B, IL15, IL10, TNF, ALB, TNFSF11
45	histamine32 18	8.8	IL15, IL10, IL1B, ALB, CXCL9, TNF
46	tacrolimus32 34 9 9	10.7	PPARG, IL10, IL15, TNF, TNFSF11
47	vitamin d32	7.6	PAX5, PPARG, TNFSF11, ALB, IGF1, IL10
48	nitric oxide32 9 18 9	10.6	NOD2, NFKB1, TNFSF11, TNF, IL1B, IL15
49	cycloheximide32	7.0	LBP, IGF1, IL15, IL1B, TNF, IL10
50	dexamethasone32 42 34 9 9	10.6	IL10, IGF1, IL1B, IL15, CDK6, LBP

Cellular components related to pediatric crohns disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	6.4	LBP, CXCL9, TNFSF11, TNF, ALB, IGF1

Biological processes related to pediatric crohns disease according to GeneDecks:

(show all 30)

id	Name	GO ID	Score	Top Affiliating Genes
1	quaternary ammonium group transport	GO:015697	10.4	SLC22A5, SLC22A4
2	carnitine transport	GO:015879	10.4	SLC22A5, SLC22A4
3	positive regulation of interleukin-17 production	GO:032740	10.2	IL23R, IL15, NOD2
4	positive regulation of natural killer cell proliferation	GO:032819	10.1	IL15, STAT5B, IL23R
5	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.9	TNF, IL1B
6	chronic inflammatory response to antigenic stimulus	GO:002439	9.8	TNF, IL1B
7	sequestering of triglyceride	GO:030730	9.8	IL1B, TNF
8	response to lipopolysaccharide	GO:032496	9.7	LBP, STAT5B, PTGER4, IL23R
9	positive regulation of osteoclast differentiation	GO:045672	9.7	IL23R, TNF, TNFSF11
10	positive regulation of heterotypic cell-cell adhesion	GO:034116	9.7	IL1B, TNF
11	lipopolysaccharide-mediated signaling pathway	GO:031663	9.7	LBP, IL1B, TNF
12	cell maturation	GO:048469	9.7	IL15, PPARG, IHH
13	positive regulation of activated T cell proliferation	GO:042104	9.7	IGF1, STAT5B, IL23R
14	positive regulation of interleukin-6 production	GO:032755	9.6	LBP, TNF, IL1B, NOD2
15	positive regulation of interferon-gamma production	GO:032729	9.5	IL1B, TNF, IL23R
16	positive regulation of T cell proliferation	GO:042102	9.5	IL15, IL23R, IL1B
17	positive regulation of inflammatory response	GO:050729	9.5	STAT5B, PTGER4, IL15
18	receptor biosynthetic process	GO:032800	9.4	IL10, TNF
19	negative regulation of growth of symbiont in host	GO:044130	9.3	LBP, IL10, TNF
20	positive regulation of cytokine secretion	GO:050715	9.3	TNF, PTGER4, IL10
21	cellular response to organic cyclic compound	GO:071407	9.2	PPARG, TNF, IL1B
22	positive regulation of mitosis	GO:045840	9.2	IGF1, IL1B, TNF
23	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.1	NFKB1, NOD2, TNFSF11, IL1B, TNF
24	positive regulation of smooth muscle cell proliferation	GO:048661	9.1	IGF1, TNF, STAT5B
25	negative regulation of cytokine secretion involved in immune response	GO:002740	9.0	TNF, IL10
26	cell-cell signaling	GO:007267	8.7	IL10, CXCL9, IHH, IL1B, IL15
27	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	8.3	PPARG, TNF, TNFSF11, IL1B, IL10
28	anti-apoptosis	GO:006916	8.0	IL10, NFKB1, IL1B, IGF1, TNF
29	inflammatory response	GO:006954	8.0	CXCL9, IL10, IL15, IL1B, IL23R, NFKB1
30	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.1	PHOX2B, STAT5B, NFKB1, ZBTB38, PPARG, TNFSF11

Molecular functions related to pediatric crohns disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	quaternary ammonium group transmembrane transporter activity	GO:015651	10.2	SLC22A4, SLC22A5
2	carnitine transporter activity	GO:015226	9.9	SLC22A4, SLC22A5
3	cytokine activity	GO:005125	7.9	IL10, CXCL9, TNFSF11, TNF, IL1B, IL15
4	protein binding	GO:005515	5.1	PPARG, NOD2, NFKB1, STAT5B, SLC22A4, SLC40A1