MCID: PDT019
MIFTS: 20

Pediatric Fibrosarcoma malady

Categories: Cancer diseases

Aliases & Classifications for Pediatric Fibrosarcoma

Aliases & Descriptions for Pediatric Fibrosarcoma:

Name: Pediatric Fibrosarcoma 12 14
Childhood Fibrosarcoma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3520
NCIt 47 C8088
UMLS 69 C0279981

Summaries for Pediatric Fibrosarcoma

MalaCards based summary : Pediatric Fibrosarcoma, also known as childhood fibrosarcoma, is related to patent ductus arteriosus and bicuspid aortic valve with hand anomalies and intracystic papillary adenoma. An important gene associated with Pediatric Fibrosarcoma is NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3), and among its related pathways/superpathways is Neurotrophic factor-mediated Trk receptor signaling. The drugs Doxorubicin and Ifosfamide have been mentioned in the context of this disorder.

Related Diseases for Pediatric Fibrosarcoma

Graphical network of the top 20 diseases related to Pediatric Fibrosarcoma:



Diseases related to Pediatric Fibrosarcoma

Symptoms & Phenotypes for Pediatric Fibrosarcoma

Drugs & Therapeutics for Pediatric Fibrosarcoma

Drugs for Pediatric Fibrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
2
Ifosfamide Approved Phase 3,Phase 2 3778-73-2 3690
3
Mechlorethamine Approved Phase 3,Phase 2 51-75-2 4033
4
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 498142 38904
5
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
6
Dactinomycin Approved Phase 3,Phase 2 50-76-0 2019 457193
7
Epirubicin Approved Phase 3,Phase 2 56420-45-2 41867
8
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
9
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
10
Cyproheptadine Approved Phase 3 129-03-3 2913
11
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
12
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
13 Alkylating Agents Phase 3,Phase 2,Phase 1
14 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
15 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
16 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
17 Isophosphamide mustard Phase 3,Phase 2
18 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
19 Anti-Infective Agents Phase 3,Phase 2
20 Antimitotic Agents Phase 3,Phase 2,Phase 1
21 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
22 Antirheumatic Agents Phase 3,Phase 2,Phase 1
23 Etoposide phosphate Phase 3,Phase 2
24 Immunosuppressive Agents Phase 3,Phase 2
25 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
26 Anti-Allergic Agents Phase 3
27 Antipruritics Phase 3
28 Dermatologic Agents Phase 3
29 Gastrointestinal Agents Phase 3
30 Histamine Antagonists Phase 3
31 Histamine H1 Antagonists Phase 3
32
Histamine Phosphate Phase 3 51-74-1 65513
33 Neurotransmitter Agents Phase 3
34
Serotonin Phase 3 50-67-9 5202
35 Serotonin Agents Phase 3
36 Serotonin Antagonists Phase 3
37
Lenograstim Approved Phase 2 135968-09-1
38
Estramustine Approved Phase 1, Phase 2 2998-57-4 18140 259331
39
Paclitaxel Approved, Vet_approved Phase 1, Phase 2 33069-62-4 36314
40
Vinblastine Approved Phase 1, Phase 2 865-21-4 13342 241903
41
Vinorelbine Approved, Investigational Phase 1, Phase 2 71486-22-1 60780 44424639
42
Thiotepa Approved Phase 2 52-24-4 5453
43
Topotecan Approved, Investigational Phase 2 119413-54-6, 123948-87-8 60700
44
Everolimus Approved Phase 2 159351-69-6 6442177
45
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
46
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
47
Mesna Approved Phase 2 3375-50-6 598
48 Imatinib Mesylate Phase 2 123596
49 Protein Kinase Inhibitors Phase 2
50 Albumin-Bound Paclitaxel Phase 1, Phase 2

Interventional clinical trials:

(show all 20)
id Name Status NCT ID Phase
1 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Unknown status NCT00346164 Phase 3
2 Ifosfamide and Doxorubicin, Radiation Therapy, and/or Surgery in Treating Young Patients With Localized Soft Tissue Sarcoma Unknown status NCT00334854 Phase 3
3 Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00002898 Phase 3
4 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3
5 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3
6 Imatinib Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma or Bone Sarcoma Completed NCT00031915 Phase 2
7 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2
8 Combination Chemotherapy in Treating Patients With Advanced Cancer Completed NCT00004105 Phase 1, Phase 2
9 Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Rare Cancer Completed NCT00002515 Phase 2
10 Oral TRK Inhibitor LOXO-101 (Larotrectinib) for Treatment of Advanced Pediatric Solid or Primary Central Nervous System Tumors Recruiting NCT02637687 Phase 1, Phase 2
11 To Find a Safe Dose and Show Early Clinical Activity of Weekly Nab-paclitaxel in Pediatric Patients With Recurrent/ Refractory Solid Tumors Recruiting NCT01962103 Phase 1, Phase 2
12 Cixutumumab and Temsirolimus in Treating Younger Patients With Recurrent or Refractory Sarcoma Active, not recruiting NCT01614795 Phase 2
13 Surgery and/or Chemotherapy in Treating Children With Infantile, Congenital, or Childhood Fibrosarcoma Terminated NCT00072280 Phase 2
14 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1
15 Celecoxib and Radiation Therapy in Treating Patients With Stage II or Stage III Soft Tissue Sarcoma of the Arm, Hand, Leg, or Foot That Has Been Removed by Surgery Completed NCT00450736 Phase 1
16 Study of RXDX-101 in Children With Recurrent or Refractory Solid Tumors and Primary CNS Tumors, With or Without TRK, ROS1, or ALK Fusions Recruiting NCT02650401 Phase 1
17 Clinical Outcome of Pediatric Dermatofibrosarcoma Protuberans Unknown status NCT00173355
18 Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue Sarcomas Completed NCT01567046
19 Genetic Study of Children With Soft Tissue Sarcoma or Rhabdomyosarcoma Completed NCT00003793
20 Glutamine in Preventing Oral Mucositis in Patients Receiving Chemotherapy for Sarcoma Withdrawn NCT00334984

Search NIH Clinical Center for Pediatric Fibrosarcoma

Genetic Tests for Pediatric Fibrosarcoma

Anatomical Context for Pediatric Fibrosarcoma

Publications for Pediatric Fibrosarcoma

Variations for Pediatric Fibrosarcoma

Expression for Pediatric Fibrosarcoma

Search GEO for disease gene expression data for Pediatric Fibrosarcoma.

Pathways for Pediatric Fibrosarcoma

Pathways related to Pediatric Fibrosarcoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.41 NTF3 NTRK3

GO Terms for Pediatric Fibrosarcoma

Biological processes related to Pediatric Fibrosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.37 NTF3 NTRK3
2 activation of MAPK activity GO:0000187 9.32 NTF3 NTRK3
3 activation of GTPase activity GO:0090630 9.26 NTF3 NTRK3
4 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.16 NTF3 NTRK3
5 activation of protein kinase B activity GO:0032148 8.96 NTF3 NTRK3
6 positive regulation of actin cytoskeleton reorganization GO:2000251 8.62 NTF3 NTRK3

Sources for Pediatric Fibrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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