MCID: PDT021
MIFTS: 48

Pediatric Osteosarcoma malady

Cancer diseases, Bone diseases categories

Summaries for Pediatric Osteosarcoma

About this section
Sources:
34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
MalaCards: Pediatric Osteosarcoma, also known as childhood osteosarcoma, is related to osteosarcoma and sarcoma. An important gene associated with Pediatric Osteosarcoma is FOLR1 (folate receptor 1 (adult)), and among its related pathways are Methotrexate Pathway, Pharmacokinetics and folate polyglutamylation. The compounds ag 331 and metoprine have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are pigmentation and craniofacial.

Aliases & Classifications for Pediatric Osteosarcoma

About this section
Sources:
9Disease Ontology, 63UMLS, 41NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Bone diseases


Aliases & Descriptions:

pediatric osteosarcoma 9
childhood osteosarcoma 63


External Ids:

Disease Ontology9 DOID:3361
NCIt41 C6585

Related Diseases for Pediatric Osteosarcoma

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Pediatric Osteosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1osteosarcoma30.9FAS, TWIST1, PDGFRA, RB1, CDKN2A, SLC19A1
2sarcoma30.2TP53, PDGFRA, TWIST1, EZR, FOLR1, RB1
3myelomeningocele10.1MTHFR
4adult acute lymphocytic leukemia10.1SHMT1, TYMS
5homocysteinemia10.1MTR, MTHFR
6homocysteinemia due to mthfr deficiency10.1MTR, MTHFR
7anencephaly10.1MTHFR, FOLR1
8megaloblastic anemia10.1MTR, MTHFR
9acromegaly10.1IGFBP3, IGF1
10insulin-like growth factor 1 resistance to10.1IGF1, IGFBP3
11nutritional deficiency disease10.1MTHFR, IGFBP3
12methylmalonic acidemia10.1MTR, MTHFR
13rabson-mendenhall syndrome10.1IGFBP3, IGF1
14idiopathic juvenile osteoporosis10.1IGF1, IGFBP3
15vitamin b12 deficiency10.1MTHFR, MTR
16actinic keratosis10.1TP53
17cleft lip10.1SLC19A1, MTR, MTHFR
18laron syndrome10.1IGF1, IGFBP3
19colon adenocarcinoma10.1TYMS, FOLR1, FAS
20anovulation10.1IGF1, IGFBP3
21growth retardation-mild developmental delay-chronic hepatitis syndrome10.1IGFBP3, IGF1
22cleft palate10.1SLC19A1, MTHFR, MTR, TWIST1
23anaplastic oligodendroglioma10.1PDGFRA, CDKN2A
24hyperhomocysteinemia10.1TYMS, MTHFR, MTR, SLC19A1
25li-fraumeni syndrome10.0TP53, CDKN2A
26benign mesothelioma10.0TP53, TYMS
27noonan syndrome10.0IGFBP3, IGF1
28down syndrome10.0SLC19A1, MTR, MTHFR
29osteochondroma10.0
30oropharyngeal cancer, adult10.0CDKN2A, TP53
31precursor t-cell acute lymphoblastic leukemia10.0TYMS, DHFR, CDKN2A, SLC19A1
32immunodeficiency with hyper igm type 210.0DHFR, MTR, TYMS, EZR
33ependymoma10.0EZR, PDGFRA, RB1
34chronic kidney failure10.0IGF1, MTR, IGFBP3, MTHFR
35gallbladder cancer10.0TP53, TYMS
36cervical intraepithelial neoplasia10.0RB1, CDKN2A, MTHFR
37nasopharynx carcinoma10.0CDKN2A, TP53
38folic acid deficiency anemia10.0SLC19A1, MTR, MTHFR, FOLR1, DHFR, TYMS
39spina bifida10.0PDGFRA, MTR, MTHFR, DHFR, FOLR1, SLC19A1
40acute lymphoblastic leukemia, childhood10.0SLC19A1, CDKN2A, DHFR, MTHFR, TYMS
41neural tube defects10.0TYMS, SLC19A1, PDGFRA, MTR, MTHFR, SHMT1
42leiomyosarcoma10.0RB1, TP53, PDGFRA
43ductal carcinoma in situ10.0CCND1, TP53
44medulloblastoma10.0DHFR, PDGFRA, TP53, EZR
45barrett's esophagus10.0TP53, CCND1, CDKN2A
46rheumatoid arthritis10.0FAS, EZR, MTHFR, DHFR, SLC19A1
47bladder carcinoma in situ10.0CCND1, CDKN2A, TP53
48pancreatic cancer10.0CDKN2A, FAS, TYMS
49esophageal cancer10.0CDKN2A, CCND1, TP53
50laryngeal benign neoplasm10.0TP53, CCND1, RB1

Graphical network of the top 20 diseases related to Pediatric Osteosarcoma:



Diseases related to pediatric osteosarcoma

Symptoms for Pediatric Osteosarcoma

About this section

Drugs & Therapeutics for Pediatric Osteosarcoma

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Pediatric Osteosarcoma

Drug clinical trials:

Search ClinicalTrials for Pediatric Osteosarcoma

Search NIH Clinical Center for Pediatric Osteosarcoma

Search CenterWatch for Pediatric Osteosarcoma

Genetic Tests for Pediatric Osteosarcoma

About this section

Anatomical Context for Pediatric Osteosarcoma

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Pediatric Osteosarcoma:

34
Bone

Animal Models for Pediatric Osteosarcoma or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Pediatric Osteosarcoma:

38 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.9TP53, FAS, PDGFRA, RB1, CDKN2A
2MP:00053828.6RB1, PDGFRA, TWIST1, CCND1, FOLR1, FAS
3MP:00053718.5IGF1, TP53, FAS, MTHFR, TWIST1, PDGFRA
4MP:00053708.5IGFBP3, SHMT1, TP53, FAS, RB1, CDKN2A
5MP:00053918.3TP53, FAS, FOLR1, CCND1, MTHFR, RB1
6MP:00053698.3IGFBP3, IGF1, TP53, TWIST1, PDGFRA, RB1
7MP:00053888.2IGF1, TP53, FAS, CCND1, PDGFRA, RB1
8MP:00053858.2TP53, FAS, CCND1, TWIST1, PDGFRA, RB1
9MP:00020068.0IGF1, SHMT1, TP53, FAS, FOLR1, CCND1
10MP:00053808.0EZR, TP53, FOLR1, TWIST1, PDGFRA, RB1
11MP:00053907.8IGF1, TP53, FAS, CCND1, MTHFR, TWIST1
12MP:00107717.8IGF1, TP53, FAS, CCND1, MTHFR, PDGFRA
13MP:00053897.8IGF1, TP53, FAS, CCND1, MTHFR, PDGFRA
14MP:00053977.7IGF1, TP53, FAS, CCND1, PDGFRA, RB1
15MP:00053797.7IGFBP3, IGF1, TP53, FAS, FOLR1, CCND1
16MP:00053847.7IGF1, TP53, FAS, FOLR1, CCND1, TWIST1
17MP:00036317.6IGF1, TP53, FAS, CDKN2A, RB1, PDGFRA
18MP:00053867.6IGFBP3, TP53, FAS, CCND1, TWIST1, PDGFRA
19MP:00053817.5EZR, TP53, FAS, FOLR1, CCND1, TWIST1
20MP:00053877.3IGF1, EZR, TP53, FAS, CCND1, PDGFRA
21MP:00053786.6FAS, TP53, EZR, IGF1, IGFBP3, FOLR1
22MP:00107686.4FOLR1, FAS, TP53, EZR, SHMT1, IGF1
23MP:00053766.4SLC19A1, IGFBP3, IGF1, SHMT1, EZR, TP53

Publications for Pediatric Osteosarcoma

About this section
Sources:
53PubMed
See all sources

Articles related to Pediatric Osteosarcoma:

(show top 50)    (show all 52)
idTitleAuthorsYear
1
Upregulated expression of microRNA-214 is linked to tumor progression and adverse prognosis in pediatric osteosarcoma. (24038809)
2014
2
Endothelin-1 gene polymorphisms and risk of chemoresistant pediatric osteosarcoma. (24123836)
2013
3
Pathological fracture as the presenting feature in pediatric osteosarcoma. (23281226)
2013
4
Bronchioloalveolar carcinoma as a second malignancy in a pediatric osteosarcoma survivor: case report. (23758793)
2013
5
Combined MicroRNA-340 and ROCK1 mRNA Profiling Predicts Tumor Progression and Prognosis in Pediatric Osteosarcoma. (24398981)
2013
6
Carboplatin and doxorubicin in treatment of pediatric osteosarcoma: a 9-year single institute experience in the Northern Region of Thailand. (23621194)
2013
7
Clinical relations of methotrexate pharmacokinetics in the treatment for pediatric osteosarcoma. (22652833)
2012
8
Case-parent analysis of variation in pubertal hormone genes and pediatric osteosarcoma: a Children's Oncology Group (COG) study. (23205180)
2012
9
Plasma proteomic profiling of pediatric osteosarcoma. (22083817)
2012
10
Correlation of non-mass-like abnormal MR signal intensity with pathological findings surrounding pediatric osteosarcoma and Ewing's sarcoma. (22406919)
2012
11
Serum tumor markers in pediatric osteosarcoma: a summary review. (22587902)
2012
12
Location of pulmonary metastasis in pediatric osteosarcoma is predictive of outcome. (21763830)
2011
13
Primary pediatric osteosarcoma of the skull. (22134292)
2011
14
Elevated expression of CXC chemokines in pediatric osteosarcoma patients. (20806347)
2011
15
Two pediatric osteosarcoma cases with delayed methotrexate excretion: its clinical course and management. (21509165)
2011
16
Survival outcomes of pediatric osteosarcoma and Ewing's sarcoma: a comparison of surgery type within the SEER database, 1988-2007. (22223058)
2011
17
Staged lengthening arthroplasty for pediatric osteosarcoma around the knee. (19885713)
2010
18
Lengthening of intercalary allograft combined with free vascularized fibular graft after reconstruction in pediatric osteosarcoma of femur. (19950438)
2010
19
Prognostic significance of early lymphocyte recovery in pediatric osteosarcoma. (20734401)
2010
20
Proteomic analysis of chemonaive pediatric osteosarcomas and corresponding normal bone reveals multiple altered molecular targets. (19492781)
2009
21
Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression. (19159907)
2009
22
Clinical characteristics and treatment results of pediatric osteosarcoma: the role of high dose chemotherapy with autologous stem cell transplantation. (19688126)
2008
23
Treatment results of pediatric osteosarcoma: twenty-year experience. (17314654)
2007
24
Exploratory analysis of Fas gene polymorphisms in pediatric osteosarcoma patients. (18090928)
2007
25
The cause and clinical significance of central tumor photopenia on thallium scintigraphy of pediatric osteosarcoma of the extremity. (17242270)
2007
26
Toxicity prevention with amifostine in pediatric osteosarcoma patients treated with cisplatin and doxorubicin. (17710657)
2007
27
KIT gene in pediatric osteosarcomas: could it be a new therapeutic target? (17294449)
2007
28
Identification of a plasma proteomic signature to distinguish pediatric osteosarcoma from benign osteochondroma. (16673437)
2006
29
Tumor necrosis in pediatric osteosarcoma: impact of modern therapies. (16766682)
2006
30
An expression signature classifies chemotherapy-resistant pediatric osteosarcoma. (15753370)
2005
31
Pediatric osteosarcoma: a 35-year experience in Slovenia. (16020121)
2005
32
Frequent genomic abnormalities at TWIST in human pediatric osteosarcomas. (15900593)
2005
33
Improved survival in primary nonmetastatic pediatric osteosarcoma of the extremity. (16131881)
2005
34
HER2 amplification and overexpression is not present in pediatric osteosarcoma: a tissue microarray study. (16211448)
2005
35
Biology and therapeutic advances for pediatric osteosarcoma. (15266096)
2004
36
Superior survival in treatment of primary nonmetastatic pediatric osteosarcoma of the extremity. (12794015)
2003
37
Genetic and epigenetic alterations of the cell cycle regulators and tumor suppressor genes in pediatric osteosarcomas. (12759621)
2003
38
High-resolution mapping of amplifications and deletions in pediatric osteosarcoma by use of CGH analysis of cDNA microarrays. (14506695)
2003
39
Loss of p16(INK4a) expression correlates with decreased survival in pediatric osteosarcomas. (11241308)
2001
40
Dynamic magnetic resonance imaging of regional contrast access as an additional prognostic factor in pediatric osteosarcoma. (11413510)
2001
41
Circulating concentrations of IGF-I and IGFBP-3 are not predictive of incidence or clinical behavior of pediatric osteosarcoma. (11344491)
2001
42
Neoadjuvant chemotherapy for pediatric osteosarcoma patients. (9010116)
1997
43
NCCN pediatric osteosarcoma practice guidelines. The National Comprehensive Cancer Network. (8985965)
1996
44
Mutational activation of ras genes is absent in pediatric osteosarcoma. (7850751)
1995
45
Pediatric osteosarcoma - treatment of the primary tumor with intravenous cis-diamminedichloroplatinum-ii (cdp) - comparison of the results with the reported efficacy of intraarterial cdp. (21573359)
1993
46
Pediatric osteosarcoma: treatment of the primary tumor with intraarterial cis-diamminedichloroplatinum-II (CDP)--advantages, disadvantages, and controversial issues. (8096762)
1993
47
Development and characterization of pediatric osteosarcoma xenografts. (2328504)
1990
48
Pediatric osteosarcoma. Successful retreatment of relapsed primary tumor and soft tissue recurrence with intraarterial cis-diamminedichloroplatin-II. (2386906)
1990
49
Pediatric osteosarcoma: therapeutic strategies, results, and prognostic factors derived from a 10-year experience. (2230890)
1990
50
Auditory function in pediatric osteosarcoma patients treated with multiple doses of cis-diamminedichloroplatinum(II). (2910492)
1989

Variations for Pediatric Osteosarcoma

About this section

Expression for genes affiliated with Pediatric Osteosarcoma

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pediatric Osteosarcoma

Search GEO for disease gene expression data for Pediatric Osteosarcoma.

Pathways for genes affiliated with Pediatric Osteosarcoma

About this section
Sources:
51PathCards, 52PharmGKB, 39NCBI BioSystems Database, 56Reactome, 31KEGG, 61Thomson Reuters, 54QIAGEN, 13EMD Millipore, 58SinoBiological, 5Cell Signaling Technology
See all sources

Pathways related to Pediatric Osteosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.1SLC19A1, FOLR1
2
Show member pathways
Glycine Metabolism39
glycine biosynthesis I39
folate transformations39
10.1SHMT1, MTR
39.9IGF1, IGFBP3
4
Show member pathways
L-serine degradation39
pentose phosphate pathway (oxidative branch)39
formaldehyde oxidation II (glutathione-dependent)39
9.8SHMT1, MTHFR, MTR
5
Show member pathways
9.6CDKN2A, TP53
69.6TYMS, DHFR, RB1
7
Show member pathways
FAS pathway and Stress induction of HSP regulation39
Apoptosis and survival FAS signaling cascades61
Caspase cascade in apoptosis39
9.5RB1, FAS, IGF1
8
Show member pathways
Signal transduction PTEN pathway61
9.4CCND1, TP53, IGF1
9
Show member pathways
9.4IGF1, TP53, CCND1
10
Show member pathways
flavin biosynthesis IV (mammalian)39
molybdenum cofactor biosynthesis39
coenzyme A biosynthesis39
thiamin salvage III39
alanine biosynthesis III39
thio-molybdenum cofactor biosynthesis39
biotin-carboxyl carrier protein assembly39
9.3SHMT1, DHFR, MTHFR, MTR, SLC19A1
11
Show member pathways
One Carbon Metabolism39
dTMP de novo biosynthesis (mitochondrial)39
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate39
Trans-sulfuration and one carbon metabolism39
methionine salvage39
Methionine metabolism61
9.3TYMS, SHMT1, DHFR, MTHFR, MTR
129.3RB1, TWIST1, FAS, IGF1
139.3TP53, CCND1, RB1
149.3TP53, CCND1, RB1
15
Show member pathways
Prostate Cancer39
Integrated Cancer pathway39
Steroid Biosynthesis39
9.3TP53, CCND1, RB1
16
Show member pathways
9.3TYMS, TP53, DHFR, MTHFR
179.2TP53, RB1, CDKN2A
189.2TP53, RB1, CDKN2A
19
Show member pathways
Translation Non genomic rapid action of Androgen Receptor61
9.2CCND1, EZR, IGF1
209.2MIR210, CCND1, TP53
21
Show member pathways
Integrin-mediated cell adhesion39
Focal Adhesion39
9.1RB1, PDGFRA, CCND1, IGF1
229.1PDGFRA, CCND1, TP53, IGF1
239.1SHMT1, DHFR, MTHFR, MTR, PDGFRA, SLC19A1
24
Show member pathways
Immune response IL 4 signaling pathway61
Signal transduction AKT signaling61
9.1IGFBP3, IGF1, TP53, CCND1
25
Show member pathways
TRAIL signaling pathway39
9.1FAS, RFC1, EZR
269.1IGFBP3, TP53, FAS, RB1
27
Show member pathways
Apoptosis Modulation and Signaling39
Apoptosis39
9.1IGF1, TP53, FAS, CDKN2A
28
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.0RB1, CCND1, FAS, TP53
29
Show member pathways
9.0RB1, CCND1, FAS, TP53
30
Show member pathways
8.9TP53, CCND1, RB1, CDKN2A
31
Show member pathways
Cell cycle39
8.9CDKN2A, RB1, CCND1, TP53
32
Show member pathways
8.9CDKN2A, RB1, CCND1, TP53
338.9CDKN2A, RB1, CCND1, TP53
348.8TYMS, TP53, DHFR, CCND1, RB1
35
Show member pathways
8.7IGF1, TP53, PDGFRA, RB1, CDKN2A
36
Show member pathways
8.6TYMS, TP53, CCND1, RB1, CDKN2A
378.6CDKN2A, RB1, PDGFRA, CCND1, TP53
388.6IGFBP3, IGF1, TP53, RB1, CDKN2A
39
Show member pathways
Proteasome Degradation39
Immune response Antigen presentation by MHC class I61
8.5TP53, RFC1, FAS, CCND1, RB1
40
Show member pathways
8.4TYMS, TP53, DHFR, CCND1, RB1, CDKN2A
41
Show member pathways
8.3IGF1, TP53, CCND1, PDGFRA, RB1, CDKN2A
42
Show member pathways
Signaling Pathways in Glioblastoma39
8.3IGF1, TP53, CCND1, PDGFRA, RB1, CDKN2A
438.3IGF1, TP53, CCND1, PDGFRA, RB1, CDKN2A
44
Show member pathways
8.3IGF1, TP53, CCND1, PDGFRA, RB1, CDKN2A
458.3TYMS, IGFBP3, IGF1, TP53, FAS, CCND1
468.3IGF1, EZR, TP53, FAS, CCND1, TWIST1
478.0IGF1, TP53, FAS, CCND1, PDGFRA, RB1
48
Show member pathways
7.9TYMS, TP53, RFC1, DHFR, CCND1, RB1
49
Show member pathways
DNA damage response39
7.5CDKN2A, IGFBP3, IGF1, TP53, RFC1, FAS
507.1EZR, TP53, CCND1, MIR214, MIR210, PDGFRA

Compounds for genes affiliated with Pediatric Osteosarcoma

About this section
Sources:
46Novoseek, 12DrugBank, 25HMDB, 52PharmGKB, 62Tocris Bioscience
See all sources

Compounds related to Pediatric Osteosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 199)
idCompoundScoreTop Affiliating Genes
1ag 3314610.1SLC19A1, TYMS, DHFR
2metoprine4610.0SLC19A1, DHFR, TYMS
3ag 3374610.0SLC19A1, TYMS, DHFR
4pt5234610.0SLC19A1, DHFR, TYMS
55-methyltetrahydrofolate46 1210.9FOLR1, SLC19A1, MTR, MTHFR
6b vitamins469.9TYMS, SHMT1, MTHFR, MTR
710-formyltetrahydrofolate469.9SLC19A1, MTR, DHFR, MTHFR
8Tetrahydrofolic acid25 1210.8SHMT1, MTR, DHFR, MTHFR
9ag 2034469.8DHFR, SLC19A1, TYMS
10folic acid52 25 1211.7MTHFR, SLC19A1, DHFR, FOLR1
11trimetrexate46 1210.7TYMS, DHFR, FOLR1, SLC19A1, CDKN2A
12tomudex469.6SLC19A1, FOLR1, TP53, TYMS, DHFR
13leucovorin46 52 1211.5FOLR1, MTHFR, SLC19A1, DHFR, TYMS, SHMT1
14tetrahydrofolate469.5MTHFR, TYMS, SLC19A1, MTR, DHFR, SHMT1
15vitamin b12469.4IGF1, MTR, MTHFR, TYMS, IGFBP3
16fluorouracil52 1210.2MTHFR, SHMT1, TP53, SLC19A1, TYMS, CCND1
17purine46 2510.1SLC19A1, DHFR, SHMT1, CDKN2A, TYMS, MTHFR
18valine469.1DHFR, MTR, IGFBP3, CDKN2A, MTHFR, TYMS
19irinotecan46 52 1211.1MTHFR, SLC19A1, TYMS, SHMT1, CDKN2A, TP53
20olomoucine46 1210.0RB1, CDKN2A, TP53, CCND1
215-aza-2deoxycytidine469.0TP53, SLC19A1, IGFBP3, FAS, FOLR1, CDKN2A
22n-(4-hydroxyphenyl)retinamide469.0CCND1, RB1, TP53, IGFBP3, IGF1
23depsipeptide469.0RB1, TP53, FAS, CCND1, CDKN2A
24carboplatin46 52 1210.9MTHFR, TP53, RB1, SLC19A1, TYMS
25mitomycin c468.9TYMS, FAS, DHFR, RB1, TP53
26cytarabine46 52 1210.9RB1, TYMS, CDKN2A, DHFR, FAS, TP53
27vincristine46 52 1210.8MTR, CDKN2A, SLC19A1, CCND1, TP53, RB1
28hydroxyurea46 52 1210.8TYMS, TP53, DHFR, PDGFRA, CDKN2A
29egcg468.7TP53, IGFBP3, CCND1, RB1, CDKN2A, FAS
30etoposide46 52 62 1211.7TP53, FAS, DHFR, TYMS, IGFBP3, IGF1
31gemcitabine46 52 1210.6CCND1, DHFR, MTHFR, TP53, TYMS
32dihydrofolate468.6DHFR, SHMT1, TYMS, SLC19A1, FOLR1, MTR
33butyrate468.3TYMS, TP53, FAS, DHFR, IGFBP3, CDKN2A
34adriamycin468.3IGF1, TP53, FAS, DHFR, TYMS, CDKN2A
35cysteine468.2TYMS, RB1, IGFBP3, FAS, DHFR, MTHFR
365fluorouracil468.1CDKN2A, SLC19A1, MTHFR, DHFR, TP53, RB1
37ly294002468.1IGF1, TP53, IGFBP3, EZR, FAS, CCND1
38folate468.1CDKN2A, TYMS, IGFBP3, DHFR, FOLR1, CCND1
39paraffin468.0RB1, TP53, CDKN2A, EZR, PDGFRA, CCND1
40thymidine46 259.0RB1, CCND1, MTHFR, TP53, IGF1, TYMS
41arginine467.9FAS, TYMS, IGFBP3, IGF1, TP53, RFC1
42methotrexate52 46 129.9TYMS, IGFBP3, SHMT1, DHFR, FOLR1, CCND1
43vegf467.9RB1, IGFBP3, IGF1, TP53, FAS, CCND1
44paclitaxel46 52 129.7SLC19A1, CDKN2A, RB1, TWIST1, CCND1, FOLR1
45doxorubicin46 52 129.7TYMS, MTR, IGFBP3, TP53, FAS, DHFR
46retinoic acid46 258.6RB1, PDGFRA, CCND1, TP53, FAS, IGF1
47thymidylate467.5DHFR, SLC19A1, FOLR1, CCND1, MTHFR, MTR
48cisplatin46 52 62 1210.4TYMS, IGFBP3, TP53, SLC19A1, CDKN2A, RB1
49estrogen466.9TWIST1, EZR, IGFBP3, IGF1, TP53, DHFR
50serine466.3TP53, EZR, SHMT1, IGF1, IGFBP3, TYMS

GO Terms for genes affiliated with Pediatric Osteosarcoma

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Pediatric Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor binding protein complexGO:0169429.8IGFBP3, IGF1
2nucleoplasmGO:0056548.1TP53, RFC1, CCND1, RB1, CDKN2A, TYMS
3cytosolGO:0058297.4CDKN2A, TYMS, SHMT1, EZR, TP53, FAS
4nucleusGO:0056346.6TYMS, IGFBP3, SHMT1, TP53, RFC1, FAS

Biological processes related to Pediatric Osteosarcoma according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1folic acid transportGO:01588410.4SLC19A1, FOLR1
2tetrahydrofolate interconversionGO:03599910.3MTHFR, SHMT1
3response to folic acidGO:05159310.2TYMS, MTHFR
4positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.1IGF1, IGFBP3
5Leydig cell differentiationGO:03332710.1PDGFRA, CCND1
6mitotic G1 DNA damage checkpointGO:03157110.0TP53, CCND1
7folic acid metabolic processGO:0466559.9SLC19A1, MTHFR, FOLR1, SHMT1
8cell cycle checkpointGO:0000759.9RB1, CDKN2A
9replicative senescenceGO:0903999.9CDKN2A, TP53
10myoblast differentiationGO:0454459.9IGF1, RB1
11water-soluble vitamin metabolic processGO:0067679.9SHMT1, MTHFR, MTR, SLC19A1
12vitamin metabolic processGO:0067669.9SLC19A1, MTR, MTHFR, SHMT1
13regulation of transcription involved in G1/S transition of mitotic cell cycleGO:0000839.8RB1, TYMS
14phosphatidylinositol-mediated signalingGO:0480159.7TYMS, IGF1, PDGFRA
15positive regulation of cell cycle arrestGO:0711589.5CDKN2A, TP53
16G1/S transition of mitotic cell cycleGO:0000829.4TYMS, CCND1, RB1, CDKN2A
17response to X-rayGO:0101659.4CCND1, TP53
18cell cycle arrestGO:0070509.3CDKN2A, RB1, TP53
19Ras protein signal transductionGO:0072659.3IGF1, TP53, RB1, CDKN2A
20negative regulation of cell proliferationGO:0082859.2CDKN2A, TP53, IGF1, IGFBP3
21positive regulation of transcription from RNA polymerase II promoterGO:0459448.9IGF1, TP53, TWIST1, RB1, CDKN2A
22mitotic cell cycleGO:0002788.9CDKN2A, RB1, CCND1, RFC1, TYMS
23positive regulation of transcription, DNA-templatedGO:0458938.7IGF1, TP53, RFC1, RB1, CDKN2A

Molecular functions related to Pediatric Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1folic acid bindingGO:0055429.9SLC19A1, FOLR1, TYMS
2folic acid transporter activityGO:0085179.8FOLR1, SLC19A1
3MDM2/MDM4 family protein bindingGO:0973719.5CDKN2A, TP53
4transcription factor bindingGO:0081348.7TP53, CCND1, TWIST1, RB1, CDKN2A
5protein bindingGO:0055156.4IGF1, EZR, TP53, RFC1, FAS, CCND1

Products for genes affiliated with Pediatric Osteosarcoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pediatric Osteosarcoma

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet