MCID: PDT021
MIFTS: 48

Pediatric Osteosarcoma malady

Bone diseases category

Summaries for Pediatric Osteosarcoma

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MalaCards: Pediatric Osteosarcoma, also known as childhood osteosarcoma, is related to osteosarcoma and sarcoma. An important gene associated with Pediatric Osteosarcoma is SHMT1 (serine hydroxymethyltransferase 1 (soluble)), and among its related pathways are glycine biosynthesis I and E2F mediated regulation of DNA replication. The compounds butyrate and serine have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and colon, and related mouse phenotypes are vision/eye and nervous system.

Aliases & Classifications for Pediatric Osteosarcoma

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8Disease Ontology, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

pediatric osteosarcoma 8
childhood osteosarcoma 60


External Ids:

Disease Ontology8 DOID:3361
NCIt39 C6585

Related Diseases for Pediatric Osteosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Pediatric Osteosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 157)
idRelated DiseaseScoreTop Affiliating Genes
1osteosarcoma31.2TP53, TWIST1, SLC19A1, DHFR, EZR, CDKN2A
2sarcoma30.2PDGFRA, FOLR1, RB1, EZR, DHFR, TWIST1
3bone osteosarcoma10.0
4supratentorial primitive neuroectodermal tumor10.0
5primitive neuroectodermal tumor10.0
6endometriosis10.0PDGFRA
7chordoma10.0PDGFRA
8chondrosarcoma10.0PDGFRA
9malignant pleural mesothelioma10.0TYMS
10psoriasis10.0DHFR
11desmoid tumor10.0PDGFRA
12fanconi's anemia10.0DHFR
13angiosarcoma10.0PDGFRA
14multiple sclerosis10.0MTR
15hepatitis b10.0DHFR
16leishmaniasis10.0DHFR
17alzheimer's disease10.0MTR
18leiomyoma10.0PDGFRA
19dementia10.0MTR
20herpes simplex10.0DHFR
21seminoma10.0PDGFRA
22hepatitis c10.0FAS
23cervical squamous cell carcinoma10.0CDKN2A
24liver cirrhosis10.0IGFBP3
25graves' disease10.0FAS
26parathyroid carcinoma10.0CCND1
27cervical adenocarcinoma10.0CDKN2A
28chagas disease10.0DHFR
29adult acute lymphocytic leukemia10.0SHMT1, TYMS
30myelomeningocele10.0MTHFR
31fibrosarcoma10.0PDGFRA, DHFR
32schizophrenia10.0MTHFR
33meningioma10.0EZR
34parathyroid adenoma10.0CCND1
35congenital heart defect10.0MTHFR
36myelodysplastic syndromes10.0FAS, PDGFRA
37silicosis10.0FAS
38myeloid leukemia10.0DHFR, FAS
39eclampsia10.0MTHFR
40galactosemia10.0IGF1
41placental abruption10.0MTHFR
42uremia10.0IGF1
43anaplastic oligodendroglioma10.0PDGFRA, CDKN2A
44malt lymphoma10.0CCND1
45hyperprolactinemia10.0IGF1
46acute leukemia10.0MTHFR, DHFR
47hemangioblastoma10.0EZR
48anencephaly10.0MTHFR, FOLR1
49malaria10.0DHFR, TYMS
50gastrointestinal stromal tumor10.0PDGFRA, EZR

Graphical network of the top 20 diseases related to Pediatric Osteosarcoma:



Diseases related to pediatric osteosarcoma

Clinical Features for Pediatric Osteosarcoma

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Drugs & Therapeutics for Pediatric Osteosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Pediatric Osteosarcoma

Drug clinical trials:

Search ClinicalTrials for Pediatric Osteosarcoma

Search NIH Clinical Center for Pediatric Osteosarcoma

Search CenterWatch for Pediatric Osteosarcoma

Genetic Tests for Pediatric Osteosarcoma

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Anatomical Context for Pediatric Osteosarcoma

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32MalaCards
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MalaCards organs/tissues related to Pediatric Osteosarcoma:

32
Bone, Testes, Colon

Animal Models for Pediatric Osteosarcoma or affiliated genes

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36MGI
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Publications for Pediatric Osteosarcoma

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50PubMed
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Articles related to Pediatric Osteosarcoma:

(show top 50)    (show all 67)
idTitleAuthorsYear
1
Upregulated expression of microRNA-214 is linked to tumor progression and adverse prognosis in pediatric osteosarcoma. (24038809)
2014
2
I9Np63 Promotes Pediatric Neuroblastoma and Osteosarcoma by Regulating Tumor Angiogenesis. (24154873)
2014
3
Survival of pediatric patients after relapsed osteosarcoma: the St. Jude Children's Research Hospital experience. (23625626)
2013
4
Endothelin-1 gene polymorphisms and risk of chemoresistant pediatric osteosarcoma. (24123836)
2013
5
Pathological fracture as the presenting feature in pediatric osteosarcoma. (23281226)
2013
6
A review of targeted therapies evaluated by the pediatric preclinical testing program for osteosarcoma. (23755370)
2013
7
Metastatic osteosarcoma to the stomach and ascending colon in a pediatric patient causing gastrointestinal hemorrhage. (23583157)
2013
8
Bronchioloalveolar carcinoma as a second malignancy in a pediatric osteosarcoma survivor: case report. (23758793)
2013
9
Carboplatin and doxorubicin in treatment of pediatric osteosarcoma: a 9-year single institute experience in the Northern Region of Thailand. (23621194)
2013
10
Case-parent analysis of variation in pubertal hormone genes and pediatric osteosarcoma: a Children's Oncology Group (COG) study. (23205180)
2012
11
Correlation of non-mass-like abnormal MR signal intensity with pathological findings surrounding pediatric osteosarcoma and Ewing's sarcoma. (22406919)
2012
12
Serum tumor markers in pediatric osteosarcoma: a summary review. (22587902)
2012
13
Location of pulmonary metastasis in pediatric osteosarcoma is predictive of outcome. (21763830)
2011
14
Elevated expression of CXC chemokines in pediatric osteosarcoma patients. (20806347)
2011
15
Association of the highly prevalent TP53 R337H mutation with pediatric choroid plexus carcinoma and osteosarcoma in southeast Brazil. (21192060)
2011
16
Survival outcomes of pediatric osteosarcoma and Ewing's sarcoma: a comparison of surgery type within the SEER database, 1988-2007. (22223058)
2011
17
Ambulatory high-dose methotrexate administration among pediatric osteosarcoma patients in an urban, underserved setting is feasible, safe, and cost-effective. (20949591)
2010
18
Case report: a pediatric case of cementoblastoma with histologic and radiographic features of an osteoblastoma and osteosarcoma. (20737258)
2010
19
Staged lengthening arthroplasty for pediatric osteosarcoma around the knee. (19885713)
2010
20
Lengthening of intercalary allograft combined with free vascularized fibular graft after reconstruction in pediatric osteosarcoma of femur. (19950438)
2010
21
Prognostic significance of early lymphocyte recovery in pediatric osteosarcoma. (20734401)
2010
22
Proteomic analysis of chemonaive pediatric osteosarcomas and corresponding normal bone reveals multiple altered molecular targets. (19492781)
2009
23
Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression. (19159907)
2009
24
Clinical characteristics and treatment results of pediatric osteosarcoma: the role of high dose chemotherapy with autologous stem cell transplantation. (19688126)
2008
25
Involvement of MET/TWIST/APC combination or the potential role of ossification factors in pediatric high-grade osteosarcoma oncogenesis. (17786187)
2007
26
Exploratory analysis of Fas gene polymorphisms in pediatric osteosarcoma patients. (18090928)
2007
27
The cause and clinical significance of central tumor photopenia on thallium scintigraphy of pediatric osteosarcoma of the extremity. (17242270)
2007
28
Toxicity prevention with amifostine in pediatric osteosarcoma patients treated with cisplatin and doxorubicin. (17710657)
2007
29
KIT gene in pediatric osteosarcomas: could it be a new therapeutic target? (17294449)
2007
30
Identification of a plasma proteomic signature to distinguish pediatric osteosarcoma from benign osteochondroma. (16673437)
2006
31
Primary bone osteosarcoma in the pediatric age: state of the art. (16860938)
2006
32
Pediatric osteosarcoma: a 35-year experience in Slovenia. (16020121)
2005
33
High-dose ifosfamide in relapsed pediatric osteosarcoma: therapeutic effects and renal toxicity. (15503294)
2005
34
Frequent genomic abnormalities at TWIST in human pediatric osteosarcomas. (15900593)
2005
35
Improved survival in primary nonmetastatic pediatric osteosarcoma of the extremity. (16131881)
2005
36
HER2 amplification and overexpression is not present in pediatric osteosarcoma: a tissue microarray study. (16211448)
2005
37
Superior survival in treatment of primary nonmetastatic pediatric osteosarcoma of the extremity. (12794015)
2003
38
High-resolution mapping of amplifications and deletions in pediatric osteosarcoma by use of CGH analysis of cDNA microarrays. (14506695)
2003
39
A chemosensitive pediatric extraosseous osteosarcoma: case report and review of the literature. (12544778)
2003
40
Loss of p16(INK4a) expression correlates with decreased survival in pediatric osteosarcomas. (11241308)
2001
41
Dynamic magnetic resonance imaging of regional contrast access as an additional prognostic factor in pediatric osteosarcoma. (11413510)
2001
42
Circulating concentrations of IGF-I and IGFBP-3 are not predictive of incidence or clinical behavior of pediatric osteosarcoma. (11344491)
2001
43
Li-Fraumeni syndrome in pediatric patients with soft tissue sarcoma or osteosarcoma. (9291635)
1997
44
Neoadjuvant chemotherapy for pediatric osteosarcoma patients. (9010116)
1997
45
Mutational activation of ras genes is absent in pediatric osteosarcoma. (7850751)
1995
46
Pediatric osteosarcoma - treatment of the primary tumor with intravenous cis-diamminedichloroplatinum-ii (cdp) - comparison of the results with the reported efficacy of intraarterial cdp. (21573359)
1993
47
Pediatric osteosarcoma: treatment of the primary tumor with intraarterial cis-diamminedichloroplatinum-II (CDP)--advantages, disadvantages, and controversial issues. (8096762)
1993
48
Pediatric osteosarcoma. Successful retreatment of relapsed primary tumor and soft tissue recurrence with intraarterial cis-diamminedichloroplatin-II. (2386906)
1990
49
Pediatric osteosarcoma: therapeutic strategies, results, and prognostic factors derived from a 10-year experience. (2230890)
1990
50
Auditory function in pediatric osteosarcoma patients treated with multiple doses of cis-diamminedichloroplatinum(II). (2910492)
1989

Genetic Variations for Pediatric Osteosarcoma

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Expression for genes affiliated with Pediatric Osteosarcoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pediatric Osteosarcoma

Search GEO for disease gene expression data for Pediatric Osteosarcoma.

Pathways for genes affiliated with Pediatric Osteosarcoma

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Sources:
37NCBI BioSystems Database, 53Reactome, 49PharmGKB, 12EMD Millipore, 29KEGG, 51QIAGEN, 4Cell Signaling Technology
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Pathways related to Pediatric Osteosarcoma according to GeneCards/GeneDecks:

(show all 34)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8SLC19A1, DHFR, TYMS
2
Hide members
9.7RB1, TYMS, DHFR
39.7DHFR, TYMS, RB1
4
Hide members
9.7SHMT1, MTR, MTHFR
5
Hide members
9.6MTHFR, TYMS, DHFR
6
Apoptosis and survival Caspase cascade
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9.5FAS, RB1, IGF1
79.5TP53, RB1, CCND1
8
Hide members
9.4TP53, CDKN2A, RB1
99.4TP53, CDKN2A, RB1
10
Transcription P53 signaling pathway
Hide members
9.4RB1, CDKN2A, TP53
11
Hide members
9.4TP53, IGF1, PDGFRA
12
Hide members
9.3CCND1, RB1, TYMS, CDKN2A
139.3TWIST1, IGF1, RB1, FAS
14
Hide members
9.3IGF1, RB1, PDGFRA, CCND1
15
Hide members
9.2MTHFR, MTR, SHMT1, DHFR, SLC19A1
16
Hide members
9.2MTHFR, MTR, SHMT1, TYMS, DHFR
17
Hide members
9.2MTHFR, MTR, SHMT1, TYMS, DHFR
18
Hide members
9.2CCND1, FAS, RB1, TP53
199.2MTHFR, TYMS, DHFR, TP53
20
Hide members
9.1TP53, CDKN2A, RB1, CCND1
219.1TP53, CDKN2A, RB1, CCND1
22
Hide members
9.1CCND1, RB1, CDKN2A, TP53
239.1FAS, RB1, IGFBP3, TP53
24
Hide members
9.1TP53, IGF1, RB1, PDGFRA
25
Hide members
9.1CCND1, RB1, TYMS, CDKN2A, DHFR
26
Hide members
9.0CCND1, IGFBP3, IGF1, TP53
278.9CCND1, PDGFRA, RB1, CDKN2A, TP53
288.7TP53, CDKN2A, IGF1, IGFBP3, RB1
298.7TP53, EZR, CDKN2A, PDGFRA, CCND1
308.5CCND1, PDGFRA, RB1, IGF1, CDKN2A, TP53
318.3CCND1, FAS, IGF1, EZR, TWIST1, TP53
328.2CCND1, PDGFRA, FAS, RB1, IGF1, CDKN2A
338.2CCND1, PDGFRA, FAS, IGFBP3, IGF1, TYMS
34
Hide members
8.1TP53, CDKN2A, IGF1, IGFBP3, RB1, FAS

Compounds for genes affiliated with Pediatric Osteosarcoma

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Pediatric Osteosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 151)
idCompoundScoreTop Affiliating Genes
1butyrate4410.6DHFR
2serine4410.6CCND1
3paraffin4410.2EZR
4pt5234410.1SLC19A1, TYMS, DHFR
5ag 3374410.1TYMS, DHFR, SLC19A1
6metoprine4410.1SLC19A1, DHFR, TYMS
7ag 3314410.1DHFR, TYMS, SLC19A1
8ag 20344410.0TYMS, DHFR, SLC19A1
95-methyltetrahydrofolate44 1110.9FOLR1, MTHFR, MTR, SLC19A1
10b vitamins449.8MTHFR, MTR, SHMT1, TYMS
1110-formyltetrahydrofolate449.8MTHFR, MTR, DHFR, SLC19A1
12Tetrahydrofolic acid11 2410.8MTHFR, SHMT1, DHFR, MTR
13folic acid49 11 2411.8SLC19A1, DHFR, MTHFR, FOLR1
14depsipeptide449.8TP53, CCND1, CDKN2A
151843u89449.8SLC19A1, TYMS, DHFR
16edatrexate449.8SLC19A1, DHFR, TYMS
17trimetrexate44 1110.7CDKN2A, DHFR, SLC19A1, TYMS, FOLR1
18ly294002449.7CCND1, RB1, EZR
19leucovorin44 49 1111.6TYMS, MTHFR, SLC19A1, DHFR, FOLR1
20tomudex449.5SLC19A1, DHFR, TP53, FOLR1, TYMS
21lometrexol449.5SLC19A1, TYMS, FOLR1
22n-phosphonacetyl-l-aspartate449.4TYMS, TP53, DHFR
23tetrahydrofolate449.4MTHFR, MTR, SHMT1, TYMS, SLC19A1, DHFR
24etoposide44 49 59 1112.4DHFR, IGF1, RB1, FAS, TYMS
25olomoucine44 1110.4CDKN2A, CCND1, TP53, RB1
26aphidicolin449.3TP53, DHFR, TYMS, RB1
27fluorouracil49 1110.3TP53, MTHFR, TYMS, CCND1
28vitamin b12449.2TYMS, IGF1, IGFBP3, MTR, MTHFR
29hydroxyurea44 49 1111.1DHFR, CDKN2A, TYMS, PDGFRA, TP53
30mitomycin c449.1RB1, FAS, TP53, DHFR, TYMS
31purine44 2410.1SHMT1, SLC19A1, DHFR, CDKN2A, TYMS, MTR
32n-(4-hydroxyphenyl)retinamide449.1CCND1, IGF1, IGFBP3, RB1, TP53
33cytarabine44 49 1111.1FAS, RB1, DHFR, TP53, CDKN2A, TYMS
34gemcitabine44 49 1111.0TYMS, TP53, DHFR, MTHFR, CCND1
35valine449.0MTR, CDKN2A, MTHFR, IGFBP3, TYMS, DHFR
365-aza-2deoxycytidine449.0TP53, FOLR1, FAS, IGFBP3, CDKN2A, SLC19A1
37dihydrofolate448.7TYMS, SHMT1, MTR, RB1, FOLR1, CCND1
38adriamycin448.4IGF1, FAS, CCND1, RB1, TYMS, CDKN2A
39paclitaxel44 49 1110.3TP53, DHFR, CDKN2A, TYMS, IGFBP3, RB1
405fluorouracil448.2MTHFR, IGFBP3, CDKN2A, DHFR, SLC19A1, RB1
41folate448.0MTR, MTHFR, FOLR1, PDGFRA, CCND1, TYMS
42doxorubicin44 49 1110.0CDKN2A, CCND1, FOLR1, FAS, RB1, IGFBP3
43methotrexate44 49 1110.0SLC19A1, MTR, MTHFR, RB1, FOLR1, CCND1
44vegf448.0CDKN2A, PDGFRA, FAS, RB1, CCND1, IGFBP3
45thymidine44 249.0PDGFRA, TP53, TYMS, IGF1, IGFBP3, MTHFR
46arginine447.8TYMS, RFC1, CDKN2A, DHFR, SLC19A1, IGF1
47cysteine447.7MTHFR, RB1, FAS, MTR, IGFBP3, SPARCL1
48retinoic acid44 248.6FAS, TP53, RB1, IGFBP3, IGF1, CDKN2A
49thymidylate447.6FOLR1, CCND1, SHMT1, FAS, RB1, MTHFR
50cisplatin44 49 59 1110.4CDKN2A, TYMS, IGFBP3, DHFR, MTR, MTHFR

GO Terms for genes affiliated with Pediatric Osteosarcoma

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16Gene Ontology
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Cellular components related to Pediatric Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor binding protein complexGO:0169429.6IGF1, IGFBP3
2nucleoplasmGO:0056548.4RB1, TYMS, CDKN2A, TP53, RFC1, CCND1
3cytosolGO:0058297.2CCND1, FAS, MTHFR, MTR, SHMT1, TYMS

Biological processes related to Pediatric Osteosarcoma according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1G1/S transition of mitotic cell cycleGO:00008210.4TYMS
2folic acid transportGO:01588410.1FOLR1, SLC19A1
3tetrahydrofolate interconversionGO:03599910.0SHMT1, MTHFR
4folic acid metabolic processGO:0466559.8SLC19A1, SHMT1, MTHFR, FOLR1
5water-soluble vitamin metabolic processGO:0067679.7MTHFR, MTR, SHMT1, SLC19A1
6positive regulation of insulin-like growth factor receptor signaling pathwayGO:0435689.7IGF1, IGFBP3
7mitotic G1 DNA damage checkpointGO:0315719.7TP53, CCND1
8vitamin metabolic processGO:0067669.7MTHFR, MTR, SHMT1, SLC19A1
9neuron apoptotic processGO:0514029.7TP53, RB1, FAS
10Leydig cell differentiationGO:0333279.7PDGFRA, CCND1
11replicative senescenceGO:0903999.6TP53, CDKN2A
12Ras protein signal transductionGO:0072659.3RB1, IGF1, CDKN2A, TP53
13mitotic cell cycleGO:0002789.0CCND1, RB1, TYMS, CDKN2A, RFC1
14cell cycle arrestGO:0070508.8GAS7, RB1, CDKN2A, TP53

Molecular functions related to Pediatric Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1folic acid bindingGO:0055429.7SLC19A1, TYMS, FOLR1
2MDM2/MDM4 family protein bindingGO:0973719.4TP53, CDKN2A
3transcription factor bindingGO:0081349.2TP53, TWIST1, CDKN2A, RB1

Products for genes affiliated with Pediatric Osteosarcoma

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  • Antibodies
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Sources for Pediatric Osteosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet