MCID: PDT021
MIFTS: 41

Pediatric Osteosarcoma malady

Bone diseases category

Aliases & Classifications for Pediatric Osteosarcoma

About this section

Pediatric Osteosarcoma, Aliases & Descriptions:

Name: Pediatric Osteosarcoma 9
 
Childhood Osteosarcoma 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


External Ids:

Disease Ontology9 DOID:3361
NCIt38 C6585

Summaries for Pediatric Osteosarcoma

About this section


MalaCards based summary: Pediatric Osteosarcoma, also known as childhood osteosarcoma, is related to sarcoma and myelomeningocele. An important gene associated with Pediatric Osteosarcoma is FOLR1 (folate receptor 1 (adult)), and among its related pathways are Methotrexate Pathway, Pharmacokinetics and folate polyglutamylation. The compounds ag 331 and metoprine have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are pigmentation and craniofacial.

Related Diseases for Pediatric Osteosarcoma

About this section

Diseases related to Pediatric Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma29.8EZR, TP53, DHFR, FOLR1, TWIST1, PDGFRA
2myelomeningocele10.5MTHFR
3adult acute lymphocytic leukemia10.5SHMT1, TYMS
4homocysteinemia10.4MTR, MTHFR
5homocysteinemia due to mthfr deficiency10.4MTHFR, MTR
6anencephaly10.4MTHFR, FOLR1
7megaloblastic anemia10.3MTHFR, MTR
8pituitary gigantism10.3IGFBP3, IGF1
9insulin-like growth factor 1 resistance to10.3IGFBP3, IGF1
10nutritional deficiency disease10.3MTHFR, IGFBP3
11methylmalonic acidemia10.3MTHFR, MTR
12rabson-mendenhall syndrome10.3IGF1, IGFBP3
13actinic keratosis10.3TP53
14idiopathic juvenile osteoporosis10.3IGFBP3, IGF1
15vitamin b12 deficiency10.3MTR, MTHFR
16cleft lip10.3SLC19A1, MTR, MTHFR
17laron dwarfism10.3IGFBP3, IGF1
18tonsil squamous cell carcinoma10.3CCND1, CDKN2A
19colon adenocarcinoma10.3TYMS, FAS, FOLR1
20anovulation10.2IGF1, IGFBP3
21cleft palate, isolated10.2MTHFR, MTR, TWIST1, SLC19A1
22hyperhomocysteinemia10.2TYMS, MTHFR, MTR, SLC19A1
23anaplastic oligodendroglioma10.2PDGFRA, CDKN2A
24gallbladder adenoma10.2RB1, CDKN2A
25noonan syndrome 110.2IGFBP3, IGF1
26li-fraumeni syndrome10.2TP53, CDKN2A
27down syndrome10.2SLC19A1, MTR, MTHFR
28benign mesothelioma10.2TYMS, TP53
29oropharynx cancer10.2TP53, CDKN2A
30precursor t-cell acute lymphoblastic leukemia10.2SLC19A1, CDKN2A, DHFR, TYMS
31hiv-110.1MTR, DHFR, EZR, TYMS
32ependymoma10.1EZR, PDGFRA, RB1
33mesothelioma10.1TYMS, DHFR, FOLR1, CDKN2A, SLC19A1
34chronic kidney failure10.1IGFBP3, IGF1, MTHFR, MTR
35nasopharynx carcinoma10.1TP53, CDKN2A
36cervical intraepithelial neoplasia10.1MTHFR, RB1, CDKN2A
37gallbladder cancer10.1TYMS, TP53
38folic acid deficiency anemia10.1SLC19A1, MTR, MTHFR, FOLR1, DHFR, TYMS
39neural tube defects10.1DHFR, FOLR1, MTHFR, MTR, PDGFRA, SLC19A1
40osteochondroma10.1
41acute lymphoblastic leukemia, childhood10.0TYMS, DHFR, MTHFR, CDKN2A, SLC19A1
42leiomyosarcoma10.0TP53, PDGFRA, RB1
43ductal carcinoma in situ10.0CCND1, TP53
44medulloblastoma10.0EZR, TP53, DHFR, PDGFRA
45barrett esophagus/esophageal adenocarcinoma10.0CDKN2A, CCND1, TP53
46rheumatoid arthritis10.0EZR, FAS, DHFR, MTHFR, SLC19A1
47pancreatic cancer10.0TYMS, FAS, CDKN2A
48esophageal cancer10.0TP53, CCND1, CDKN2A
49laryngeal carcinoma10.0TP53, CCND1, RB1
50bladder cancer, somatic9.9TP53, RB1, CDKN2A

Graphical network of the top 20 diseases related to Pediatric Osteosarcoma:



Diseases related to pediatric osteosarcoma

Symptoms for Pediatric Osteosarcoma

About this section

Drugs & Therapeutics for Pediatric Osteosarcoma

About this section

Drug clinical trials:

Search ClinicalTrials for Pediatric Osteosarcoma

Search NIH Clinical Center for Pediatric Osteosarcoma

Genetic Tests for Pediatric Osteosarcoma

About this section

Anatomical Context for Pediatric Osteosarcoma

About this section

MalaCards organs/tissues related to Pediatric Osteosarcoma:

31
Bone

Animal Models for Pediatric Osteosarcoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Pediatric Osteosarcoma:

35 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.9TP53, FAS, PDGFRA, RB1, CDKN2A
2MP:00053828.6RB1, PDGFRA, TWIST1, CCND1, FOLR1, FAS
3MP:00053718.5IGF1, TP53, FAS, MTHFR, TWIST1, PDGFRA
4MP:00053708.5IGFBP3, SHMT1, TP53, FAS, RB1, CDKN2A
5MP:00053918.3TP53, FAS, FOLR1, CCND1, MTHFR, RB1
6MP:00053698.3IGFBP3, IGF1, TP53, TWIST1, PDGFRA, RB1
7MP:00053888.2IGF1, TP53, FAS, CCND1, PDGFRA, RB1
8MP:00053858.2TP53, FAS, CCND1, TWIST1, PDGFRA, RB1
9MP:00020068.0IGF1, SHMT1, TP53, FAS, FOLR1, CCND1
10MP:00053808.0EZR, TP53, FOLR1, TWIST1, PDGFRA, RB1
11MP:00053907.8IGF1, TP53, FAS, CCND1, MTHFR, TWIST1
12MP:00107717.8IGF1, TP53, FAS, CCND1, MTHFR, PDGFRA
13MP:00053897.8IGF1, TP53, FAS, CCND1, MTHFR, PDGFRA
14MP:00053977.7IGF1, TP53, FAS, CCND1, PDGFRA, RB1
15MP:00053797.7IGFBP3, IGF1, TP53, FAS, FOLR1, CCND1
16MP:00053847.7IGF1, TP53, FAS, FOLR1, CCND1, TWIST1
17MP:00036317.6IGF1, TP53, FAS, CDKN2A, RB1, PDGFRA
18MP:00053867.6IGFBP3, TP53, FAS, CCND1, TWIST1, PDGFRA
19MP:00053817.5EZR, TP53, FAS, FOLR1, CCND1, TWIST1
20MP:00053877.3IGF1, EZR, TP53, FAS, CCND1, PDGFRA
21MP:00053786.6FAS, TP53, EZR, IGF1, IGFBP3, FOLR1
22MP:00107686.4FOLR1, FAS, TP53, EZR, SHMT1, IGF1
23MP:00053766.4SLC19A1, IGFBP3, IGF1, SHMT1, EZR, TP53

Publications for Pediatric Osteosarcoma

About this section

Articles related to Pediatric Osteosarcoma:

(show top 50)    (show all 61)
idTitleAuthorsYear
1
In silico functional analyses and discovery of survival-associated microRNA signatures in pediatric osteosarcoma. (25594070)
2014
2
Impaired testicular function after an ifosfamide-containing regimen for pediatric osteosarcoma: a case series and review of the literature. (24667129)
2014
3
Experience of Pediatric Osteosarcoma of the Extremity at a Single Institution in Taiwan: Prognostic Factors and Impact on Survival. (25323470)
2014
4
Management of local recurrence of pediatric osteosarcoma following limb-sparing surgery. (24558066)
2014
5
Pediatric Osteosarcoma: A Single Institution's Experience. (25365431)
2014
6
Upregulated expression of microRNA-214 is linked to tumor progression and adverse prognosis in pediatric osteosarcoma. (24038809)
2014
7
Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma. (24703847)
2014
8
Endothelin-1 gene polymorphisms and risk of chemoresistant pediatric osteosarcoma. (24123836)
2013
9
Pathological fracture as the presenting feature in pediatric osteosarcoma. (23281226)
2013
10
Bronchioloalveolar carcinoma as a second malignancy in a pediatric osteosarcoma survivor: case report. (23758793)
2013
11
Combined MicroRNA-340 and ROCK1 mRNA Profiling Predicts Tumor Progression and Prognosis in Pediatric Osteosarcoma. (24398981)
2013
12
Clinical relations of methotrexate pharmacokinetics in the treatment for pediatric osteosarcoma. (22652833)
2012
13
Case-parent analysis of variation in pubertal hormone genes and pediatric osteosarcoma: a Children's Oncology Group (COG) study. (23205180)
2012
14
Plasma proteomic profiling of pediatric osteosarcoma. (22083817)
2012
15
Correlation of non-mass-like abnormal MR signal intensity with pathological findings surrounding pediatric osteosarcoma and Ewing's sarcoma. (22406919)
2012
16
Location of pulmonary metastasis in pediatric osteosarcoma is predictive of outcome. (21763830)
2011
17
Primary pediatric osteosarcoma of the skull. (22134292)
2011
18
Elevated expression of CXC chemokines in pediatric osteosarcoma patients. (20806347)
2011
19
Two pediatric osteosarcoma cases with delayed methotrexate excretion: its clinical course and management. (21509165)
2011
20
Ambulatory high-dose methotrexate administration among pediatric osteosarcoma patients in an urban, underserved setting is feasible, safe, and cost-effective. (20949591)
2010
21
Staged lengthening arthroplasty for pediatric osteosarcoma around the knee. (19885713)
2010
22
Proteomic analysis of chemonaive pediatric osteosarcomas and corresponding normal bone reveals multiple altered molecular targets. (19492781)
2009
23
Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression. (19159907)
2009
24
Clinical characteristics and treatment results of pediatric osteosarcoma: the role of high dose chemotherapy with autologous stem cell transplantation. (19688126)
2008
25
Treatment results of pediatric osteosarcoma: twenty-year experience. (17314654)
2007
26
Exploratory analysis of Fas gene polymorphisms in pediatric osteosarcoma patients. (18090928)
2007
27
The cause and clinical significance of central tumor photopenia on thallium scintigraphy of pediatric osteosarcoma of the extremity. (17242270)
2007
28
Toxicity prevention with amifostine in pediatric osteosarcoma patients treated with cisplatin and doxorubicin. (17710657)
2007
29
Identification of a plasma proteomic signature to distinguish pediatric osteosarcoma from benign osteochondroma. (16673437)
2006
30
Tumor necrosis in pediatric osteosarcoma: impact of modern therapies. (16766682)
2006
31
An expression signature classifies chemotherapy-resistant pediatric osteosarcoma. (15753370)
2005
32
Pediatric osteosarcoma: a 35-year experience in Slovenia. (16020121)
2005
33
High-dose ifosfamide in relapsed pediatric osteosarcoma: therapeutic effects and renal toxicity. (15503294)
2005
34
Frequent genomic abnormalities at TWIST in human pediatric osteosarcomas. (15900593)
2005
35
Improved survival in primary nonmetastatic pediatric osteosarcoma of the extremity. (16131881)
2005
36
Biology and therapeutic advances for pediatric osteosarcoma. (15266096)
2004
37
Superior survival in treatment of primary nonmetastatic pediatric osteosarcoma of the extremity. (12794015)
2003
38
Genetic and epigenetic alterations of the cell cycle regulators and tumor suppressor genes in pediatric osteosarcomas. (12759621)
2003
39
Loss of p16(INK4a) expression correlates with decreased survival in pediatric osteosarcomas. (11241308)
2001
40
Dynamic magnetic resonance imaging of regional contrast access as an additional prognostic factor in pediatric osteosarcoma. (11413510)
2001
41
Circulating concentrations of IGF-I and IGFBP-3 are not predictive of incidence or clinical behavior of pediatric osteosarcoma. (11344491)
2001
42
Neoadjuvant chemotherapy for pediatric osteosarcoma patients. (9010116)
1997
43
NCCN pediatric osteosarcoma practice guidelines. The National Comprehensive Cancer Network. (8985965)
1996
44
Mutational activation of ras genes is absent in pediatric osteosarcoma. (7850751)
1995
45
Pediatric osteosarcoma - treatment of the primary tumor with intravenous cis-diamminedichloroplatinum-ii (cdp) - comparison of the results with the reported efficacy of intraarterial cdp. (21573359)
1993
46
Pediatric osteosarcoma: treatment of the primary tumor with intraarterial cis-diamminedichloroplatinum-II (CDP)--advantages, disadvantages, and controversial issues. (8096762)
1993
47
Development and characterization of pediatric osteosarcoma xenografts. (2328504)
1990
48
Pediatric osteosarcoma. Successful retreatment of relapsed primary tumor and soft tissue recurrence with intraarterial cis-diamminedichloroplatin-II. (2386906)
1990
49
Pediatric osteosarcoma: therapeutic strategies, results, and prognostic factors derived from a 10-year experience. (2230890)
1990
50
Auditory function in pediatric osteosarcoma patients treated with multiple doses of cis-diamminedichloroplatinum(II). (2910492)
1989

Variations for Pediatric Osteosarcoma

About this section

Expression for genes affiliated with Pediatric Osteosarcoma

About this section
Search GEO for disease gene expression data for Pediatric Osteosarcoma.

Pathways for genes affiliated with Pediatric Osteosarcoma

About this section

Pathways related to Pediatric Osteosarcoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 55)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.1SLC19A1, FOLR1
2
Show member pathways
Glycine Metabolism36
glycine biosynthesis I36
folate transformations36
10.1SHMT1, MTR
39.9IGF1, IGFBP3
4
Show member pathways
L-serine degradation36
pentose phosphate pathway (oxidative branch)36
formaldehyde oxidation II (glutathione-dependent)36
9.8SHMT1, MTHFR, MTR
5
Show member pathways
9.6CDKN2A, TP53
69.6TYMS, DHFR, RB1
7
Show member pathways
FAS pathway and Stress induction of HSP regulation36
Apoptosis and survival FAS signaling cascades58
Caspase cascade in apoptosis36
9.5RB1, FAS, IGF1
8
Show member pathways
Signal transduction PTEN pathway58
9.4CCND1, TP53, IGF1
9
Show member pathways
9.4IGF1, TP53, CCND1
10
Show member pathways
flavin biosynthesis IV (mammalian)36
molybdenum cofactor biosynthesis36
coenzyme A biosynthesis36
thiamin salvage III36
alanine biosynthesis III36
thio-molybdenum cofactor biosynthesis36
biotin-carboxyl carrier protein assembly36
9.3SHMT1, DHFR, MTHFR, MTR, SLC19A1
11
Show member pathways
One Carbon Metabolism36
dTMP de novo biosynthesis (mitochondrial)36
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate36
Trans-sulfuration and one carbon metabolism36
methionine salvage36
Methionine metabolism58
9.3TYMS, SHMT1, DHFR, MTHFR, MTR
129.3RB1, TWIST1, FAS, IGF1
139.3TP53, CCND1, RB1
149.3TP53, CCND1, RB1
15
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
9.3TP53, CCND1, RB1
16
Show member pathways
9.3TYMS, TP53, DHFR, MTHFR
179.2TP53, RB1, CDKN2A
189.2TP53, RB1, CDKN2A
19
Show member pathways
Translation Non genomic rapid action of Androgen Receptor58
9.2CCND1, EZR, IGF1
209.2MIR210, CCND1, TP53
21
Show member pathways
Integrin-mediated cell adhesion36
Focal Adhesion36
9.1RB1, PDGFRA, CCND1, IGF1
229.1PDGFRA, CCND1, TP53, IGF1
239.1SHMT1, DHFR, MTHFR, MTR, PDGFRA, SLC19A1
24
Show member pathways
Development IGF RI signaling
Immune response IL 4 signaling pathway58
Signal transduction AKT signaling58
9.1IGFBP3, IGF1, TP53, CCND1
25
Show member pathways
TRAIL signaling pathway36
9.1FAS, RFC1, EZR
269.1IGFBP3, TP53, FAS, RB1
27
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
9.1IGF1, TP53, FAS, CDKN2A
28
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.0RB1, CCND1, FAS, TP53
29
Show member pathways
9.0RB1, CCND1, FAS, TP53
30
Show member pathways
8.9TP53, CCND1, RB1, CDKN2A
31
Show member pathways
Cell cycle36
8.9CDKN2A, RB1, CCND1, TP53
32
Show member pathways
8.9CDKN2A, RB1, CCND1, TP53
338.9CDKN2A, RB1, CCND1, TP53
348.8TYMS, TP53, DHFR, CCND1, RB1
35
Show member pathways
8.7IGF1, TP53, PDGFRA, RB1, CDKN2A
36
Show member pathways
8.6TYMS, TP53, CCND1, RB1, CDKN2A
378.6CDKN2A, RB1, PDGFRA, CCND1, TP53
388.6IGFBP3, IGF1, TP53, RB1, CDKN2A
39
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I58
8.5TP53, RFC1, FAS, CCND1, RB1
40
Show member pathways
8.4TYMS, TP53, DHFR, CCND1, RB1, CDKN2A
41
Show member pathways
8.3IGF1, TP53, CCND1, PDGFRA, RB1, CDKN2A
42
Show member pathways
Signaling Pathways in Glioblastoma36
8.3IGF1, TP53, CCND1, PDGFRA, RB1, CDKN2A
438.3IGF1, TP53, CCND1, PDGFRA, RB1, CDKN2A
44
Show member pathways
8.3IGF1, TP53, CCND1, PDGFRA, RB1, CDKN2A
458.3TYMS, IGFBP3, IGF1, TP53, FAS, CCND1
468.3IGF1, EZR, TP53, FAS, CCND1, TWIST1
478.0IGF1, TP53, FAS, CCND1, PDGFRA, RB1
48
Show member pathways
7.9TYMS, TP53, RFC1, DHFR, CCND1, RB1
49
Show member pathways
DNA damage response36
7.5CDKN2A, IGFBP3, IGF1, TP53, RFC1, FAS
507.1EZR, TP53, CCND1, MIR214, MIR210, PDGFRA

Compounds for genes affiliated with Pediatric Osteosarcoma

About this section

Compounds related to Pediatric Osteosarcoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 199)
idCompoundScoreTop Affiliating Genes
1ag 3314310.1SLC19A1, TYMS, DHFR
2metoprine4310.0SLC19A1, DHFR, TYMS
3ag 3374310.0SLC19A1, TYMS, DHFR
4pt5234310.0SLC19A1, DHFR, TYMS
55-methyltetrahydrofolate43 1210.9FOLR1, SLC19A1, MTR, MTHFR
6b vitamins439.9TYMS, SHMT1, MTHFR, MTR
710-formyltetrahydrofolate439.9SLC19A1, MTR, DHFR, MTHFR
8Tetrahydrofolic acid24 1210.8SHMT1, MTR, DHFR, MTHFR
9ag 2034439.8DHFR, SLC19A1, TYMS
10folic acid49 24 1211.7MTHFR, SLC19A1, DHFR, FOLR1
11trimetrexate43 1210.7TYMS, DHFR, FOLR1, SLC19A1, CDKN2A
12tomudex439.6SLC19A1, FOLR1, TP53, TYMS, DHFR
13leucovorin43 49 1211.5FOLR1, MTHFR, SLC19A1, DHFR, TYMS, SHMT1
14tetrahydrofolate439.5MTHFR, TYMS, SLC19A1, MTR, DHFR, SHMT1
15vitamin b12439.4IGF1, MTR, MTHFR, TYMS, IGFBP3
16fluorouracil49 1210.2MTHFR, SHMT1, TP53, SLC19A1, TYMS, CCND1
17purine43 2410.1SLC19A1, DHFR, SHMT1, CDKN2A, TYMS, MTHFR
18valine439.1DHFR, MTR, IGFBP3, CDKN2A, MTHFR, TYMS
19irinotecan43 49 1211.1MTHFR, SLC19A1, TYMS, SHMT1, CDKN2A, TP53
20olomoucine43 1210.0RB1, CDKN2A, TP53, CCND1
215-aza-2deoxycytidine439.0TP53, SLC19A1, IGFBP3, FAS, FOLR1, CDKN2A
22n-(4-hydroxyphenyl)retinamide439.0CCND1, RB1, TP53, IGFBP3, IGF1
23depsipeptide439.0RB1, TP53, FAS, CCND1, CDKN2A
24carboplatin43 49 1210.9MTHFR, TP53, RB1, SLC19A1, TYMS
25mitomycin c438.9TYMS, FAS, DHFR, RB1, TP53
26cytarabine43 49 1210.9RB1, TYMS, CDKN2A, DHFR, FAS, TP53
27vincristine43 49 1210.8MTR, CDKN2A, SLC19A1, CCND1, TP53, RB1
28hydroxyurea43 49 1210.8TYMS, TP53, DHFR, PDGFRA, CDKN2A
29egcg438.7TP53, IGFBP3, CCND1, RB1, CDKN2A, FAS
30etoposide43 49 59 1211.7TP53, FAS, DHFR, TYMS, IGFBP3, IGF1
31gemcitabine43 49 1210.6CCND1, DHFR, MTHFR, TP53, TYMS
32dihydrofolate438.6DHFR, SHMT1, TYMS, SLC19A1, FOLR1, MTR
33butyrate438.3TYMS, TP53, FAS, DHFR, IGFBP3, CDKN2A
34adriamycin438.3IGF1, TP53, FAS, DHFR, TYMS, CDKN2A
35cysteine438.2TYMS, RB1, IGFBP3, FAS, DHFR, MTHFR
365fluorouracil438.1CDKN2A, SLC19A1, MTHFR, DHFR, TP53, RB1
37ly294002438.1IGF1, TP53, IGFBP3, EZR, FAS, CCND1
38folate438.1CDKN2A, TYMS, IGFBP3, DHFR, FOLR1, CCND1
39paraffin438.0RB1, TP53, CDKN2A, EZR, PDGFRA, CCND1
40thymidine43 249.0RB1, CCND1, MTHFR, TP53, IGF1, TYMS
41arginine437.9FAS, TYMS, IGFBP3, IGF1, TP53, RFC1
42methotrexate49 43 129.9TYMS, IGFBP3, SHMT1, DHFR, FOLR1, CCND1
43vegf437.9RB1, IGFBP3, IGF1, TP53, FAS, CCND1
44paclitaxel43 49 129.7SLC19A1, CDKN2A, RB1, TWIST1, CCND1, FOLR1
45doxorubicin43 49 129.7TYMS, MTR, IGFBP3, TP53, FAS, DHFR
46retinoic acid43 248.6RB1, PDGFRA, CCND1, TP53, FAS, IGF1
47thymidylate437.5DHFR, SLC19A1, FOLR1, CCND1, MTHFR, MTR
48cisplatin43 49 59 1210.4TYMS, IGFBP3, TP53, SLC19A1, CDKN2A, RB1
49estrogen436.9TWIST1, EZR, IGFBP3, IGF1, TP53, DHFR
50serine436.3TP53, EZR, SHMT1, IGF1, IGFBP3, TYMS

GO Terms for genes affiliated with Pediatric Osteosarcoma

About this section

Cellular components related to Pediatric Osteosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor binding protein complexGO:00169429.8IGFBP3, IGF1
2nucleoplasmGO:00056548.1RB1, TYMS, TP53, CDKN2A, CCND1, RFC1
3cytosolGO:00058297.4FAS, CDKN2A, TYMS, SHMT1, EZR, TP53
4nucleusGO:00056346.6CDKN2A, TP53, FAS, SHMT1, IGFBP3, TYMS

Biological processes related to Pediatric Osteosarcoma according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1folic acid transportGO:001588410.4SLC19A1, FOLR1
2tetrahydrofolate interconversionGO:003599910.3MTHFR, SHMT1
3response to folic acidGO:005159310.2TYMS, MTHFR
4positive regulation of insulin-like growth factor receptor signaling pathwayGO:004356810.1IGF1, IGFBP3
5Leydig cell differentiationGO:003332710.1PDGFRA, CCND1
6mitotic G1 DNA damage checkpointGO:003157110.0TP53, CCND1
7folic acid metabolic processGO:00466559.9SLC19A1, MTHFR, FOLR1, SHMT1
8cell cycle checkpointGO:00000759.9RB1, CDKN2A
9replicative senescenceGO:00903999.9CDKN2A, TP53
10myoblast differentiationGO:00454459.9IGF1, RB1
11water-soluble vitamin metabolic processGO:00067679.9SHMT1, MTHFR, MTR, SLC19A1
12vitamin metabolic processGO:00067669.9SLC19A1, MTR, MTHFR, SHMT1
13regulation of transcription involved in G1/S transition of mitotic cell cycleGO:00000839.8RB1, TYMS
14phosphatidylinositol-mediated signalingGO:00480159.7TYMS, IGF1, PDGFRA
15positive regulation of cell cycle arrestGO:00711589.5CDKN2A, TP53
16G1/S transition of mitotic cell cycleGO:00000829.4TYMS, CCND1, RB1, CDKN2A
17response to X-rayGO:00101659.4CCND1, TP53
18cell cycle arrestGO:00070509.3CDKN2A, RB1, TP53
19Ras protein signal transductionGO:00072659.3IGF1, TP53, RB1, CDKN2A
20negative regulation of cell proliferationGO:00082859.2CDKN2A, TP53, IGF1, IGFBP3
21positive regulation of transcription from RNA polymerase II promoterGO:00459448.9IGF1, TP53, TWIST1, RB1, CDKN2A
22mitotic cell cycleGO:00002788.9CDKN2A, RB1, CCND1, RFC1, TYMS
23positive regulation of transcription, DNA-templatedGO:00458938.7IGF1, TP53, RFC1, RB1, CDKN2A

Molecular functions related to Pediatric Osteosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1folic acid bindingGO:00055429.9SLC19A1, FOLR1, TYMS
2folic acid transporter activityGO:00085179.8FOLR1, SLC19A1
3MDM2/MDM4 family protein bindingGO:00973719.5CDKN2A, TP53
4transcription factor bindingGO:00081348.7TP53, CCND1, TWIST1, RB1, CDKN2A
5protein bindingGO:00055156.4IGF1, EZR, TP53, RFC1, FAS, CCND1

Products for genes affiliated with Pediatric Osteosarcoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Pediatric Osteosarcoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet