Pediatric Osteosarcoma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Pediatric Osteosarcoma

MalaCards based summary: Pediatric Osteosarcoma, also known as childhood osteosarcoma, is related to sarcoma and osteosarcoma. An important gene associated with Pediatric Osteosarcoma is FOLR1 (folate receptor 1 (adult)), and among its related pathways are Methotrexate Pathway, Pharmacokinetics and folate polyglutamylation. The compounds ag 331 and metoprine have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are pigmentation and craniofacial.

Aliases & Classifications for Pediatric Osteosarcoma

Sources:
⁹Disease Ontology, ⁶¹UMLS, ³⁹NCIt
See all sources

Pediatric Osteosarcoma, Aliases & Descriptions:

Name: Pediatric Osteosarcoma ⁹

Childhood Osteosarcoma ⁶¹

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Bone diseases

External Ids:

Disease Ontology⁹ DOID:3361

NCIt³⁹ C6585

UMLS⁶¹ C1332986

Related Diseases for Pediatric Osteosarcoma

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Pediatric Osteosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 91)

id	Related Disease	Score	Top Affiliating Genes
1	sarcoma	29.8	EZR, TP53, DHFR, FOLR1, TWIST1, PDGFRA
2	osteosarcoma	29.7	SLC19A1, TYMS, IGFBP3, IGF1, CDKN2A, RB1
3	myelomeningocele	10.5	MTHFR
4	adult acute lymphocytic leukemia	10.5	SHMT1, TYMS
5	homocysteinemia	10.4	MTR, MTHFR
6	homocysteinemia due to mthfr deficiency	10.4	MTHFR, MTR
7	anencephaly	10.4	MTHFR, FOLR1
8	megaloblastic anemia	10.4	MTHFR, MTR
9	acromegaly	10.4	IGFBP3, IGF1
10	insulin-like growth factor 1 resistance to	10.3	IGFBP3, IGF1
11	nutritional deficiency disease	10.3	MTHFR, IGFBP3
12	methylmalonic acidemia	10.3	MTHFR, MTR
13	rabson-mendenhall syndrome	10.3	IGF1, IGFBP3
14	actinic keratosis	10.3	TP53
15	idiopathic juvenile osteoporosis	10.3	IGFBP3, IGF1
16	vitamin b12 deficiency	10.3	MTR, MTHFR
17	cleft lip	10.3	SLC19A1, MTR, MTHFR
18	laron syndrome	10.3	IGFBP3, IGF1
19	colon adenocarcinoma	10.3	TYMS, FAS, FOLR1
20	anovulation	10.2	IGF1, IGFBP3
21	cleft palate	10.2	MTHFR, MTR, TWIST1, SLC19A1
22	hyperhomocysteinemia	10.2	TYMS, MTHFR, MTR, SLC19A1
23	anaplastic oligodendroglioma	10.2	PDGFRA, CDKN2A
24	gallbladder adenoma	10.2	RB1, CDKN2A
25	noonan syndrome	10.2	IGFBP3, IGF1
26	li-fraumeni syndrome	10.2	TP53, CDKN2A
27	down syndrome	10.2	SLC19A1, MTR, MTHFR
28	benign mesothelioma	10.2	TYMS, TP53
29	oropharyngeal cancer, adult	10.2	TP53, CDKN2A
30	precursor t-cell acute lymphoblastic leukemia	10.2	SLC19A1, CDKN2A, DHFR, TYMS
31	immunodeficiency with hyper igm type 2	10.2	MTR, DHFR, EZR, TYMS
32	ependymoma	10.1	EZR, PDGFRA, RB1
33	malignant mesothelioma	10.1	TYMS, DHFR, FOLR1, CDKN2A, SLC19A1
34	chronic kidney failure	10.1	IGFBP3, IGF1, MTHFR, MTR
35	nasopharynx carcinoma	10.1	TP53, CDKN2A
36	cervical intraepithelial neoplasia	10.1	MTHFR, RB1, CDKN2A
37	gallbladder cancer	10.1	TYMS, TP53
38	folic acid deficiency anemia	10.1	SLC19A1, MTR, MTHFR, FOLR1, DHFR, TYMS
39	spina bifida	10.1	DHFR, FOLR1, MTHFR, MTR, PDGFRA, SLC19A1
40	acute lymphoblastic leukemia, childhood	10.1	TYMS, DHFR, MTHFR, CDKN2A, SLC19A1
41	osteochondroma	10.1
42	neural tube defects	10.0	TYMS, SHMT1, MTHFR, MTR, PDGFRA, SLC19A1
43	leiomyosarcoma	10.0	TP53, PDGFRA, RB1
44	ductal carcinoma in situ	10.0	CCND1, TP53
45	medulloblastoma	10.0	EZR, TP53, DHFR, PDGFRA
46	barrett's esophagus	10.0	CDKN2A, CCND1, TP53
47	bladder carcinoma in situ	10.0	CDKN2A, CCND1, TP53
48	rheumatoid arthritis	10.0	EZR, FAS, DHFR, MTHFR, SLC19A1
49	pancreatic cancer	10.0	TYMS, FAS, CDKN2A
50	esophageal cancer	10.0	TP53, CCND1, CDKN2A

Graphical network of the top 20 diseases related to Pediatric Osteosarcoma:

Symptoms for Pediatric Osteosarcoma

Drugs & Therapeutics for Pediatric Osteosarcoma

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Pediatric Osteosarcoma

Search NIH Clinical Center for Pediatric Osteosarcoma

Genetic Tests for Pediatric Osteosarcoma

Anatomical Context for Pediatric Osteosarcoma

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Pediatric Osteosarcoma:

³²

Bone

Animal Models for Pediatric Osteosarcoma or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Pediatric Osteosarcoma:

³⁶ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	pigmentation phenotype	MP:0001186	8.9	TP53, FAS, PDGFRA, RB1, CDKN2A
2	craniofacial phenotype	MP:0005382	8.6	RB1, PDGFRA, TWIST1, CCND1, FOLR1, FAS
3	limbs/digits/tail phenotype	MP:0005371	8.5	IGF1, TP53, FAS, MTHFR, TWIST1, PDGFRA
4	liver/biliary system phenotype	MP:0005370	8.5	IGFBP3, SHMT1, TP53, FAS, RB1, CDKN2A
5	vision/eye phenotype	MP:0005391	8.3	TP53, FAS, FOLR1, CCND1, MTHFR, RB1
6	muscle phenotype	MP:0005369	8.3	IGFBP3, IGF1, TP53, TWIST1, PDGFRA, RB1
7	respiratory system phenotype	MP:0005388	8.2	IGF1, TP53, FAS, CCND1, PDGFRA, RB1
8	cardiovascular system phenotype	MP:0005385	8.2	TP53, FAS, CCND1, TWIST1, PDGFRA, RB1
9	tumorigenesis	MP:0002006	8.0	IGF1, SHMT1, TP53, FAS, FOLR1, CCND1
10	embryogenesis phenotype	MP:0005380	8.0	EZR, TP53, FOLR1, TWIST1, PDGFRA, RB1
11	skeleton phenotype	MP:0005390	7.8	IGF1, TP53, FAS, CCND1, MTHFR, TWIST1
12	integument phenotype	MP:0010771	7.8	IGF1, TP53, FAS, CCND1, MTHFR, PDGFRA
13	reproductive system phenotype	MP:0005389	7.8	IGF1, TP53, FAS, CCND1, MTHFR, PDGFRA
14	hematopoietic system phenotype	MP:0005397	7.7	IGF1, TP53, FAS, CCND1, PDGFRA, RB1
15	endocrine/exocrine gland phenotype	MP:0005379	7.7	IGFBP3, IGF1, TP53, FAS, FOLR1, CCND1
16	cellular phenotype	MP:0005384	7.7	IGF1, TP53, FAS, FOLR1, CCND1, TWIST1
17	nervous system phenotype	MP:0003631	7.6	IGF1, TP53, FAS, CDKN2A, RB1, PDGFRA
18	behavior/neurological phenotype	MP:0005386	7.6	IGFBP3, TP53, FAS, CCND1, TWIST1, PDGFRA
19	digestive/alimentary phenotype	MP:0005381	7.5	EZR, TP53, FAS, FOLR1, CCND1, TWIST1
20	immune system phenotype	MP:0005387	7.3	IGF1, EZR, TP53, FAS, CCND1, PDGFRA
21	growth/size/body phenotype	MP:0005378	6.6	FAS, TP53, EZR, IGF1, IGFBP3, FOLR1
22	mortality/aging	MP:0010768	6.4	FOLR1, FAS, TP53, EZR, SHMT1, IGF1
23	homeostasis/metabolism phenotype	MP:0005376	6.4	SLC19A1, IGFBP3, IGF1, SHMT1, EZR, TP53

Publications for Pediatric Osteosarcoma

Sources:
⁵¹PubMed
See all sources

Articles related to Pediatric Osteosarcoma:

(show top 50) (show all 58)

id	Title	Authors	Year
1	Impaired testicular function after an ifosfamide-containing regimen for pediatric osteosarcoma: a case series and review of the literature. (24667129)	Kenney L.B.... Diller L.	2014
2	Experience of Pediatric Osteosarcoma of the Extremity at a Single Institution in Taiwan: Prognostic Factors and Impact on Survival. (25323470)	Hung G.Y.... Hsu H.E.	2014
3	Management of local recurrence of pediatric osteosarcoma following limb-sparing surgery. (24558066)	Loh A.H.... Rao B.N.	2014
4	Pediatric Osteosarcoma: A Single Institution's Experience. (25365431)	Vijayakumar V.... Megason G.	2014
5	Upregulated expression of microRNA-214 is linked to tumor progression and adverse prognosis in pediatric osteosarcoma. (24038809)	Wang Z.... Cai H.	2014
6	Endothelin-1 gene polymorphisms and risk of chemoresistant pediatric osteosarcoma. (24123836)	Zhou Y.... Ni J.	2013
7	Pathological fracture as the presenting feature in pediatric osteosarcoma. (23281226)	Lee R.K.... Li C.K.	2013
8	Bronchioloalveolar carcinoma as a second malignancy in a pediatric osteosarcoma survivor: case report. (23758793)	Okui M.... Kohno M.	2013
9	Combined MicroRNA-340 and ROCK1 mRNA Profiling Predicts Tumor Progression and Prognosis in Pediatric Osteosarcoma. (24398981)	Cai H.... Wang Z.	2013
10	Clinical relations of methotrexate pharmacokinetics in the treatment for pediatric osteosarcoma. (22652833)	Hegyi M.... KovA!cs G.T.	2012
11	Case-parent analysis of variation in pubertal hormone genes and pediatric osteosarcoma: a Children's Oncology Group (COG) study. (23205180)	Musselman J.R.... Spector L.G.	2012
12	Plasma proteomic profiling of pediatric osteosarcoma. (22083817)	Li Y.... Man T.K.	2012
13	Correlation of non-mass-like abnormal MR signal intensity with pathological findings surrounding pediatric osteosarcoma and Ewing's sarcoma. (22406919)	Masrouha K.Z.... Khoury N.J.	2012
14	Serum tumor markers in pediatric osteosarcoma: a summary review. (22587902)	Savitskaya Y.A.... Ibarra-Ponce de LeA^n J.C.	2012
15	Location of pulmonary metastasis in pediatric osteosarcoma is predictive of outcome. (21763830)	Letourneau P.A.... Hayes-Jordan A.A.	2011
16	Primary pediatric osteosarcoma of the skull. (22134292)	Kirby E.J.... Morales L.	2011
17	Elevated expression of CXC chemokines in pediatric osteosarcoma patients. (20806347)	Li Y.... Man T.K.	2011
18	Two pediatric osteosarcoma cases with delayed methotrexate excretion: its clinical course and management. (21509165)	Lee K.M.... Lee J.A.	2011
19	Ambulatory high-dose methotrexate administration among pediatric osteosarcoma patients in an urban, underserved setting is feasible, safe, and cost-effective. (20949591)	Mahadeo K.M.... Levy A.S.	2010
20	Staged lengthening arthroplasty for pediatric osteosarcoma around the knee. (19885713)	Kong C.B.... Jeon D.G.	2010
21	Proteomic analysis of chemonaive pediatric osteosarcomas and corresponding normal bone reveals multiple altered molecular targets. (19492781)	Folio C.... PatiA+o-GarcA-a A.	2009
22	Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression. (19159907)	PatiA+o-GarcA-a A.... SierrasesA_maga L.	2009
23	Clinical characteristics and treatment results of pediatric osteosarcoma: the role of high dose chemotherapy with autologous stem cell transplantation. (19688126)	Lee J.W.... Shin H.Y.	2008
24	Treatment results of pediatric osteosarcoma: twenty-year experience. (17314654)	Varan A.... BA1yA1kpamukAsu M.	2007
25	Exploratory analysis of Fas gene polymorphisms in pediatric osteosarcoma patients. (18090928)	Koshkina N.V.... Sturgis E.M.	2007
26	The cause and clinical significance of central tumor photopenia on thallium scintigraphy of pediatric osteosarcoma of the extremity. (17242270)	McCarville M.B.... Reddick W.E.	2007
27	Toxicity prevention with amifostine in pediatric osteosarcoma patients treated with cisplatin and doxorubicin. (17710657)	Gallegos-Castorena S.... Medina-SansA^n A.	2007
28	KIT gene in pediatric osteosarcomas: could it be a new therapeutic target? (17294449)	Entz-Werle N.... Babin A.	2007
29	Identification of a plasma proteomic signature to distinguish pediatric osteosarcoma from benign osteochondroma. (16673437)	Li Y.... Man T.K.	2006
30	Tumor necrosis in pediatric osteosarcoma: impact of modern therapies. (16766682)	Hendershot E.... Sung L.	2006
31	An expression signature classifies chemotherapy-resistant pediatric osteosarcoma. (15753370)	Mintz M.B.... Stephan D.A.	2005
32	Pediatric osteosarcoma: a 35-year experience in Slovenia. (16020121)	Kuhelj D.... Jereb B.	2005
33	High-dose ifosfamide in relapsed pediatric osteosarcoma: therapeutic effects and renal toxicity. (15503294)	Berrak S.G.... Jaffe N.	2005
34	Frequent genomic abnormalities at TWIST in human pediatric osteosarcomas. (15900593)	Entz-WerlAc N.... Perrin-Schmitt F.	2005
35	Improved survival in primary nonmetastatic pediatric osteosarcoma of the extremity. (16131881)	Wilkins R.M.... Odom L.	2005
36	Biology and therapeutic advances for pediatric osteosarcoma. (15266096)	Marina N.... Gorlick R.	2004
37	Superior survival in treatment of primary nonmetastatic pediatric osteosarcoma of the extremity. (12794015)	Wilkins R.M.... Camozzi A.B.	2003
38	Genetic and epigenetic alterations of the cell cycle regulators and tumor suppressor genes in pediatric osteosarcomas. (12759621)	PatiA+o-GarcA-a A.... Ariznabarreta L.S.	2003
39	Loss of p16(INK4a) expression correlates with decreased survival in pediatric osteosarcomas. (11241308)	Maitra A.... Geradts J.	2001
40	Dynamic magnetic resonance imaging of regional contrast access as an additional prognostic factor in pediatric osteosarcoma. (11413510)	Reddick W.E.... Fletcher B.D.	2001
41	Circulating concentrations of IGF-I and IGFBP-3 are not predictive of incidence or clinical behavior of pediatric osteosarcoma. (11344491)	Rodriguez-Galindo C.... Cleveland J.L.	2001
42	Neoadjuvant chemotherapy for pediatric osteosarcoma patients. (9010116)	Uchida A.... Ueda T.	1997
43	NCCN pediatric osteosarcoma practice guidelines. The National Comprehensive Cancer Network. (8985965)	O'Reilly R.... Schwartz C.	1996
44	Mutational activation of ras genes is absent in pediatric osteosarcoma. (7850751)	AntillA^n-KlA1ssmann F.... SierrasesA_maga L.	1995
45	Pediatric osteosarcoma - treatment of the primary tumor with intravenous cis-diamminedichloroplatinum-ii (cdp) - comparison of the results with the reported efficacy of intraarterial cdp. (21573359)	Jaffe N.... Kim E.	1993
46	Pediatric osteosarcoma: treatment of the primary tumor with intraarterial cis-diamminedichloroplatinum-II (CDP)--advantages, disadvantages, and controversial issues. (8096762)	Jaffe N.	1993
47	Development and characterization of pediatric osteosarcoma xenografts. (2328504)	Meyer W.H.... Look A.T.	1990
48	Pediatric osteosarcoma. Successful retreatment of relapsed primary tumor and soft tissue recurrence with intraarterial cis-diamminedichloroplatin-II. (2386906)	Epelman S.... Bianchi A.	1990
49	Pediatric osteosarcoma: therapeutic strategies, results, and prognostic factors derived from a 10-year experience. (2230890)	Hudson M.... Robertson R.	1990
50	Auditory function in pediatric osteosarcoma patients treated with multiple doses of cis-diamminedichloroplatinum(II). (2910492)	Ruiz L.... Wang Y.M.	1989

Genes related to Pediatric Osteosarcoma

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Pediatric Osteosarcoma:

(show all 20)

- Elite gene

id	Symbol	Description	Score	Implication
1	FOLR1	folate receptor 1 (adult)	20.49	GeneCards inferred via : Publications (show sections)
2	SHMT1	serine hydroxymethyltransferase 1 (soluble)	19.49	GeneCards inferred via : Publications (show sections)
3	SLC19A1	solute carrier family 19 (folate transporter), member 1	18.49	GeneCards inferred via : Publications (show sections)
4	TWIST1	twist family bHLH transcription factor 1	17.49	GeneCards inferred via : Publications (show sections)
5	DHFR	dihydrofolate reductase	16.49	GeneCards inferred via : Publications (show sections)
6	MTR	5-methyltetrahydrofolate-homocysteine methyltransferase	15.49	GeneCards inferred via : Publications (show sections)
7	TYMS	thymidylate synthetase	14.49	GeneCards inferred via : Publications (show sections)
8	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	13.49	GeneCards inferred via : Publications (show sections)
9	FAS	Fas cell surface death receptor	12.49	GeneCards inferred via : Publications (show sections)
10	IGFBP3	insulin-like growth factor binding protein 3	11.49	GeneCards inferred via : Publications (show sections)
11	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	10.49	GeneCards inferred via : Publications (show sections)
12	IGF1	insulin-like growth factor 1 (somatomedin C)	9.49	GeneCards inferred via : Publications (show sections)
13	CCND1	cyclin D1	8.49	GeneCards inferred via : Publications (show sections)
14	CDKN2A	cyclin-dependent kinase inhibitor 2A	7.49	GeneCards inferred via : Publications (show sections)
15	RB1	retinoblastoma 1	6.49	GeneCards inferred via : Publications (show sections)
16	TP53	tumor protein p53	5.49	GeneCards inferred via : Publications (show sections)
17	RFC1	replication factor C (activator 1) 1, 145kDa	4.49	GeneCards inferred via : Publications (show sections)
18	EZR	ezrin	3.49	GeneCards inferred via : Publications (show sections)
19	MIR214	microRNA 214	2.09	GeneCards inferred via : Publications (show sections)
20	MIR210	microRNA 210	1.08	GeneCards inferred via : Publications (show sections)

Products for genes related to Pediatric Osteosarcoma disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	17	-	17	17
2	Novus Biologicals	17	15	18	-

Variations for Pediatric Osteosarcoma

Expression for genes affiliated with Pediatric Osteosarcoma

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Pediatric Osteosarcoma

Search GEO for disease gene expression data for Pediatric Osteosarcoma.

Pathways for genes affiliated with Pediatric Osteosarcoma

Sources:
⁴⁹PathCards, ⁵⁰PharmGKB, ³⁷NCBI BioSystems Database, ⁵⁴Reactome, ³⁰KEGG, ⁵⁹Thomson Reuters, ⁵²QIAGEN, ¹³EMD Millipore, ⁵⁵SinoBiological, ⁵Cell Signaling Technology
See all sources

Pathways related to Pediatric Osteosarcoma according to GeneCards/GeneDecks:

(show top 50) (show all 55)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Methotrexate Pathway, Pharmacokinetics⁵⁰ Show member pathways Methotrexate Pathway (Brain Cell), Pharmacokinetics⁵⁰	10.1	FOLR1, SLC19A1
2	folate polyglutamylation³⁷ Show member pathways Glycine Metabolism³⁷ glycine biosynthesis I³⁷ folate transformations³⁷	10.1	SHMT1, MTR
3	Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)⁵⁴	9.9	IGF1, IGFBP3
4	Carbon metabolism³⁰ Show member pathways Valine, leucine and isoleucine biosynthesis³⁰ Biosynthesis of amino acids³⁰ Pentose Phosphate Pathway (Erythrocyte)⁵⁰ L-serine degradation³⁷ pentose phosphate pathway (oxidative branch)³⁷ 2-Oxocarboxylic acid metabolism³⁰ formaldehyde oxidation II (glutathione-dependent)³⁷	9.8	SHMT1, MTHFR, MTR
5	TP53 network³⁷ Show member pathways Activation, translocation and oligomerization of BAX⁵⁴	9.6	TP53, CDKN2A
6	E2F transcription factor network³⁷	9.6	RB1, DHFR, TYMS
7	Apoptosis and survival Caspase cascade⁵⁹ Show member pathways Breakdown of the nuclear lamina⁵⁴ FAS pathway and Stress induction of HSP regulation³⁷ Apoptosis and survival FAS signaling cascades⁵⁹ Caspase cascade in apoptosis³⁷ Stimulation of the cell death response by PAK-2p34⁵⁴	9.5	RB1, FAS, IGF1
8	Chks in Checkpoint Regulation⁵² Show member pathways DNA Repair Mechanisms⁵² G2-M Phase Transition⁵² Estrogen-mediated S-Phase Entry⁵² SREBP Proteolysis⁵²	9.4	CCND1, TP53, IGF1
9	Endometrial cancer³⁰ Show member pathways Colorectal cancer³⁰ Signal transduction PTEN pathway⁵⁹ Acute myeloid leukemia³⁰	9.4	CCND1, TP53, IGF1
10	Defective BTD causes biotidinase deficiency⁵⁴ Show member pathways flavin biosynthesis IV (mammalian)³⁷ Molybdenum cofactor biosynthesis⁵⁴ molybdenum cofactor biosynthesis³⁷ coenzyme A biosynthesis³⁷ Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF⁵⁴ Defective CD320 causes methylmalonic aciduria⁵⁴ Defects in vitamin and cofactor metabolism⁵⁴ Defective AMN causes hereditary megaloblastic anemia 1⁵⁴ Defects in biotin (Btn) metabolism⁵⁴ Defective MMAA causes methylmalonic aciduria type cblA⁵⁴ Biotin transport and metabolism⁵⁴ Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD⁵⁴ Metabolism of vitamins and cofactors⁵⁴ Defective HLCS causes multiple carboxylase deficiency⁵⁴ thiamin salvage III³⁷ Cobalamin (Cbl, vitamin B12) transport and metabolism⁵⁴ Vitamin B1 (thiamin) metabolism⁵⁴ Metabolism of folate and pterines⁵⁴ Vitamin B5 (pantothenate) metabolism⁵⁴ Defective MTR causes methylmalonic aciduria and homocystinuria type cblG⁵⁴ Defective MUT causes methylmalonic aciduria mut type⁵⁴ Coenzyme A biosynthesis⁵⁴ Metabolism of water-soluble vitamins and cofactors⁵⁴ Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE⁵⁴ alanine biosynthesis III³⁷ Vitamin B2 (riboflavin) metabolism⁵⁴ thio-molybdenum cofactor biosynthesis³⁷ Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC⁵⁴ Defects in cobalamin (B12) metabolism⁵⁴ Defective TCN2 causes hereditary megaloblastic anemia⁵⁴ Defective MMAB causes methylmalonic aciduria type cblB⁵⁴ biotin-carboxyl carrier protein assembly³⁷ Defective CUBN causes hereditary megaloblastic anemia 1⁵⁴ Vitamin C (ascorbate) metabolism⁵⁴ Defective GIF causes intrinsic factor deficiency⁵⁴	9.3	SHMT1, DHFR, MTHFR, MTR, SLC19A1
11	One carbon pool by folate³⁰ Show member pathways One Carbon Metabolism³⁷ dTMP de novo biosynthesis (mitochondrial)³⁷ tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate³⁷ Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics⁵⁰ Trans-sulfuration and one carbon metabolism³⁷ Antimetabolite Pathway - Folate Cycle, Pharmacodynamics⁵⁰ Methotrexate Pathway (Cancer Cell), Pharmacodynamics⁵⁰ methionine salvage³⁷ Methionine metabolism⁵⁹	9.3	DHFR, MTR, MTHFR, SHMT1, TYMS
12	Adipogenesis³⁷	9.3	RB1, FAS, TWIST1, IGF1
13	Small cell lung cancer³⁰	9.3	CCND1, RB1, TP53
14	Prostate cancer³⁰ Show member pathways Prostate Cancer³⁷ Integrated Cancer pathway³⁷ Steroid Biosynthesis³⁷	9.3	CCND1, RB1, TP53
15	Spinal Cord Injury³⁷	9.3	TP53, CCND1, RB1
16	Pyrimidine metabolism⁵⁴ Show member pathways glutamate removal from folates³⁷ Pyrimidine biosynthesis⁵⁴ Pyrimidine salvage reactions⁵⁴ UMP biosynthesis³⁷ Fluoropyrimidine Activity³⁷ Fluoropyrimidine Pathway, Pharmacodynamics⁵⁰ Fluoropyrimidine Pathway, Pharmacokinetics⁵⁰ Pyrimidine catabolism⁵⁴	9.3	TYMS, DHFR, MTHFR, TP53
17	Transcription P53 signaling pathway⁵⁹	9.2	TP53, CDKN2A, RB1
18	Inhibition of Ribosome Biogenesis by p14(ARF)⁵²	9.2	CDKN2A, RB1, TP53
19	Transcription Androgen Receptor nuclear signaling⁵⁹ Show member pathways Translation Non genomic rapid action of Androgen Receptor⁵⁹	9.2	IGF1, EZR, CCND1
20	miRNAs involved in DDR³⁷	9.2	MIR210, CCND1, TP53
21	Focal adhesion³⁰ Show member pathways HGF Pathway⁵² Integrin-mediated cell adhesion³⁷ Focal Adhesion³⁷ ECM-receptor interaction³⁰	9.1	IGF1, CCND1, PDGFRA, RB1
22	PI3K-Akt signaling pathway³⁰	9.1	CCND1, TP53, IGF1, PDGFRA
23	Disease⁵⁴	9.1	DHFR, PDGFRA, SLC19A1, MTR, MTHFR, SHMT1
24	Development IGF 1 receptor signaling⁵⁹ Show member pathways Development IGF RI signaling¹³ Immune response IL 4 signaling pathway⁵⁹ Signal transduction AKT signaling⁵⁹	9.1	TP53, IGF1, IGFBP3, CCND1
25	FAS (CD95) signaling pathway³⁷ Show member pathways TRAIL signaling pathway³⁷	9.1	EZR, RFC1, FAS
26	Direct p53 effectors³⁷	9.1	RB1, TP53, IGFBP3, FAS
27	Apoptosis⁵⁴ Show member pathways Apoptosis Modulation and Signaling³⁷ Apoptosis³⁷	9.1	TP53, CDKN2A, IGF1, FAS
28	Toll-like receptor signaling pathway³⁰ Show member pathways Chagas disease (American trypanosomiasis)³⁰ Toll-like receptor signaling pathway³⁷ Regulation of toll-like receptor signaling pathway³⁷ Hepatitis B³⁰	9.0	RB1, TP53, FAS, CCND1
29	p53 Signaling⁵² Show member pathways p53 Pathway⁵⁵	9.0	CCND1, RB1, FAS, TP53
30	Viral carcinogenesis³⁰	8.9	RB1, CCND1, TP53, CDKN2A
31	Cell cycle³⁰ Show member pathways Cell cycle³⁷	8.9	RB1, CDKN2A, CCND1, TP53
32	Cyclins and Cell Cycle Regulation⁵² Show member pathways Cell Cycle Control by BTG Proteins⁵² Phosphorylation of proteins involved in G1/S transition by active Cyclin E-Cdk2 complexes⁵⁴ G1-S Phase Transition⁵² G1 Phase⁵⁴ Cyclin D associated events in G1⁵⁴	8.9	TP53, CCND1, RB1, CDKN2A
33	Chronic myeloid leukemia³⁰ Show member pathways Pancreatic cancer³⁰	8.9	CDKN2A, CCND1, TP53, RB1
34	RB in Cancer³⁷	8.8	TYMS, DHFR, RB1, CCND1, TP53
35	Apoptotic Pathways in Synovial Fibroblasts⁵² Show member pathways Actin-Based Motility by Rho Family GTPases⁵² PPAR Pathway⁵² Cellular Apoptosis Pathway⁵² Rac1 Pathway⁵² Glioma Invasiveness⁵² eIF2 Pathway⁵² ERK5 Signaling⁵² p53 Mediated Apoptosis⁵² Mitochondrial Apoptosis⁵² Rap1 Pathway⁵² Telomerase Components in Cell Signaling⁵² Nuclear Receptor Activation by Vitamin-A⁵² DHA Signaling⁵²	8.7	IGF1, CDKN2A, RB1, PDGFRA, TP53
36	Cell Cycle / Checkpoint Control⁵ Show member pathways DNA Damage⁵	8.6	CCND1, RB1, TYMS, TP53, CDKN2A
37	HTLV-I infection³⁰	8.6	CDKN2A, RB1, TP53, CCND1, PDGFRA
38	Senescence and Autophagy³⁷	8.6	CDKN2A, IGFBP3, IGF1, TP53, RB1
39	CDK-mediated phosphorylation and removal of Cdc6⁵⁴ Show member pathways APC/C-mediated degradation of cell cycle proteins⁵⁴ Antigen processing-Cross presentation⁵⁴ Autodegradation of the E3 ubiquitin ligase COP1⁵⁴ Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)⁵⁴ SCF-beta-TrCP mediated degradation of Emi1⁵⁴ Regulation of Apoptosis⁵⁴ Regulation of PAK-2p34 activity by PS-GAP/RHG10⁵⁴ Destabilization of mRNA by KSRP⁵⁴ DNA Replication Pre-Initiation⁵⁴ Cross-presentation of particulate exogenous antigens (phagosomes)⁵⁴ Switching of origins to a post-replicative state⁵⁴ Proteasome Degradation³⁷ Regulation of mRNA Stability by Proteins that Bind AU-rich Elements⁵⁴ M/G1 Transition⁵⁴ Conversion from APC/C-Cdc20 to APC/C-Cdh1 in late anaphase⁵⁴ CDC6 association with the ORC-origin complex⁵⁴ S Phase⁵⁴ Degradation of beta-catenin by the destruction complex⁵⁴ Immune response Antigen presentation by MHC class I⁵⁹ Phosphorylation of the APC/C⁵⁴ Regulation of mitotic cell cycle⁵⁴ Cyclin A-Cdk2-associated events at S phase entry⁵⁴ Regulation of APC/C activators between G1/S and early anaphase⁵⁴ APC/C-Cdc20 mediated degradation of mitotic proteins⁵⁴ Proteasome³⁰ Association of licensing factors with the pre-replicative complex⁵⁴ ER-Phagosome pathway⁵⁴ CDT1 association with the CDC6-ORC-origin complex⁵⁴ Cell Cycle Checkpoints⁵⁴ Cyclin E associated events during G1/S transition⁵⁴ Beta-catenin phosphorylation cascade⁵⁴ Parkinson's Disease Pathway⁵² APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G1⁵⁴ APC/C-Cdc20 mediated degradation of Securin⁵⁴ Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins⁵⁴ Activation of NF-kappaB in B Cells⁵⁴ Vpu mediated degradation of CD4⁵⁴ Regulation of activated PAK-2p34 by proteasome mediated degradation⁵⁴ p53-Independent G1/S DNA damage checkpoint⁵⁴ Regulation of ornithine decarboxylase (ODC)⁵⁴ Stabilization of mRNA by HuR⁵⁴ WNT5A-dependent internalization of FZD4⁵⁴ Destabilization of mRNA by Tristetraprolin (TTP)⁵⁴ SCF(Skp2)-mediated degradation of p27/p21⁵⁴ Regulation of DNA replication⁵⁴ Role of DCC in regulating apoptosis⁵⁴ Ubiquitin-dependent degradation of Cyclin D⁵⁴ Ubiquitin Mediated Degradation of Phosphorylated Cdc25A⁵⁴ p53-Dependent G1/S DNA damage checkpoint⁵⁴ p53-Dependent G1 DNA Damage Response⁵⁴ Apoptosis⁵⁴ DNA Replication⁵⁴ Vif-mediated degradation of APOBEC3G⁵⁴ Destabilization of mRNA by AUF1 (hnRNP D0)⁵⁴ p53-Independent DNA Damage Response⁵⁴ Cross-presentation of soluble exogenous antigens (endosomes)⁵⁴ Removal of licensing factors from origins⁵⁴ Endosomal/Vacuolar pathway⁵⁴ Stabilization of p53⁵⁴ Assembly of the pre-replicative complex⁵⁴ Ubiquitin-dependent degradation of Cyclin D1⁵⁴ PCP/CE pathway⁵⁴ G1/S DNA Damage Checkpoints⁵⁴ Orc1 removal from chromatin⁵⁴ Asymmetric localization of PCP proteins⁵⁴ Autodegradation of Cdh1 by Cdh1-APC/C⁵⁴ Establishment of Sister Chromatid Cohesion⁵⁴ WNT5A-dependent internalization of FZD2, FZD5 and ROR2⁵⁴ Synthesis of DNA⁵⁴	8.5	RB1, RFC1, TP53, FAS, CCND1
40	E2F mediated regulation of DNA replication⁵⁴ Show member pathways E2F-enabled inhibition of pre-replication complex formation⁵⁴ G1/S-Specific Transcription⁵⁴ G1 to S cell cycle control³⁷ G1/S Transition⁵⁴ Mitotic G1-G1/S phases⁵⁴ Inhibition of replication initiation of damaged DNA by RB1/E2F1⁵⁴ Assembly of the ORC complex at the origin of replication⁵⁴	8.4	TP53, TYMS, CDKN2A, CCND1, RB1, DHFR
41	GPCR Pathway⁵² Show member pathways Breast Cancer Regulation by Stathmin1⁵² Pancreatic Adenocarcinoma⁵² P2Y Receptor Signaling⁵² Ras Pathway⁵² Paxillin Interactions⁵² NFAT in Immune Response⁵² Estrogen Pathway⁵²	8.3	RB1, IGF1, TP53, CCND1, PDGFRA, CDKN2A
42	Glioma³⁰ Show member pathways Melanoma³⁰ Non-small cell lung cancer³⁰ Bladder cancer³⁰ Prostate cancer³⁰ Signaling Pathways in Glioblastoma³⁷	8.3	TP53, CDKN2A, RB1, PDGFRA, CCND1, IGF1
43	Glioblastoma Multiforme⁵²	8.3	TP53, RB1, IGF1, CCND1, PDGFRA, CDKN2A
44	ERK Signaling⁵² Show member pathways ILK Signaling⁵² Molecular Mechanisms of Cancer⁵² Rho Family GTPases⁵² MAPK Signaling⁵²	8.3	IGF1, RB1, TP53, CDKN2A, PDGFRA, CCND1
45	Integrated Pancreatic Cancer Pathway³⁷	8.3	FAS, IGF1, PDGFRA, CCND1, TYMS, TP53
46	Proteoglycans in cancer³⁰	8.3	CCND1, FAS, TWIST1, TP53, EZR, IGF1
47	Pathways in cancer³⁰	8.0	IGF1, CDKN2A, TP53, RB1, PDGFRA, CCND1
48	Cell Cycle, Mitotic⁵⁴ Show member pathways Cell Cycle⁵⁴ M Phase⁵⁴	7.9	CCND1, CDKN2A, RFC1, TP53, RB1, TYMS
49	p53 signaling pathway³⁰ Show member pathways DNA damage response³⁷	7.5	RFC1, RB1, CCND1, FAS, CDKN2A, TP53
50	MicroRNAs in cancer³⁰	7.1	TP53, MIR214, MIR210, CCND1, EZR, CDKN2A

Compounds for genes affiliated with Pediatric Osteosarcoma

Sources:
⁴⁴Novoseek, ¹²DrugBank, ²⁵HMDB, ⁵⁰PharmGKB, ⁶⁰Tocris Bioscience
See all sources

Compounds related to Pediatric Osteosarcoma according to GeneCards/GeneDecks:

(show top 50) (show all 199)

id	Compound	Score	Top Affiliating Genes
1	ag 331⁴⁴	10.1	SLC19A1, TYMS, DHFR
2	metoprine⁴⁴	10.0	SLC19A1, DHFR, TYMS
3	ag 337⁴⁴	10.0	SLC19A1, TYMS, DHFR
4	pt523⁴⁴	10.0	SLC19A1, DHFR, TYMS
5	5-methyltetrahydrofolate⁴⁴ ¹²	10.9	FOLR1, SLC19A1, MTR, MTHFR
6	b vitamins⁴⁴	9.9	TYMS, SHMT1, MTHFR, MTR
7	10-formyltetrahydrofolate⁴⁴	9.9	SLC19A1, MTR, DHFR, MTHFR
8	Tetrahydrofolic acid²⁵ ¹²	10.8	SHMT1, MTR, DHFR, MTHFR
9	ag 2034⁴⁴	9.8	DHFR, SLC19A1, TYMS
10	folic acid⁵⁰ ²⁵ ¹²	11.7	MTHFR, SLC19A1, DHFR, FOLR1
11	trimetrexate⁴⁴ ¹²	10.7	TYMS, DHFR, FOLR1, SLC19A1, CDKN2A
12	tomudex⁴⁴	9.6	SLC19A1, FOLR1, TP53, TYMS, DHFR
13	leucovorin⁴⁴ ⁵⁰ ¹²	11.5	FOLR1, MTHFR, SLC19A1, DHFR, TYMS, SHMT1
14	tetrahydrofolate⁴⁴	9.5	MTHFR, TYMS, SLC19A1, MTR, DHFR, SHMT1
15	vitamin b12⁴⁴	9.4	IGF1, MTR, MTHFR, TYMS, IGFBP3
16	fluorouracil⁵⁰ ¹²	10.2	MTHFR, SHMT1, TP53, SLC19A1, TYMS, CCND1
17	purine⁴⁴ ²⁵	10.1	SLC19A1, DHFR, SHMT1, CDKN2A, TYMS, MTHFR
18	valine⁴⁴	9.1	DHFR, MTR, IGFBP3, CDKN2A, MTHFR, TYMS
19	irinotecan⁴⁴ ⁵⁰ ¹²	11.1	MTHFR, SLC19A1, TYMS, SHMT1, CDKN2A, TP53
20	olomoucine⁴⁴ ¹²	10.0	RB1, CDKN2A, TP53, CCND1
21	5-aza-2deoxycytidine⁴⁴	9.0	TP53, SLC19A1, IGFBP3, FAS, FOLR1, CDKN2A
22	n-(4-hydroxyphenyl)retinamide⁴⁴	9.0	CCND1, RB1, TP53, IGFBP3, IGF1
23	depsipeptide⁴⁴	9.0	RB1, TP53, FAS, CCND1, CDKN2A
24	carboplatin⁴⁴ ⁵⁰ ¹²	10.9	MTHFR, TP53, RB1, SLC19A1, TYMS
25	mitomycin c⁴⁴	8.9	TYMS, FAS, DHFR, RB1, TP53
26	cytarabine⁴⁴ ⁵⁰ ¹²	10.9	RB1, TYMS, CDKN2A, DHFR, FAS, TP53
27	vincristine⁴⁴ ⁵⁰ ¹²	10.8	MTR, CDKN2A, SLC19A1, CCND1, TP53, RB1
28	hydroxyurea⁴⁴ ⁵⁰ ¹²	10.8	TYMS, TP53, DHFR, PDGFRA, CDKN2A
29	egcg⁴⁴	8.7	TP53, IGFBP3, CCND1, RB1, CDKN2A, FAS
30	etoposide⁴⁴ ⁵⁰ ⁶⁰ ¹²	11.7	TP53, FAS, DHFR, TYMS, IGFBP3, IGF1
31	gemcitabine⁴⁴ ⁵⁰ ¹²	10.6	CCND1, DHFR, MTHFR, TP53, TYMS
32	dihydrofolate⁴⁴	8.6	DHFR, SHMT1, TYMS, SLC19A1, FOLR1, MTR
33	butyrate⁴⁴	8.3	TYMS, TP53, FAS, DHFR, IGFBP3, CDKN2A
34	adriamycin⁴⁴	8.3	IGF1, TP53, FAS, DHFR, TYMS, CDKN2A
35	cysteine⁴⁴	8.2	TYMS, RB1, IGFBP3, FAS, DHFR, MTHFR
36	5fluorouracil⁴⁴	8.1	CDKN2A, SLC19A1, MTHFR, DHFR, TP53, RB1
37	ly294002⁴⁴	8.1	IGF1, TP53, IGFBP3, EZR, FAS, CCND1
38	folate⁴⁴	8.1	CDKN2A, TYMS, IGFBP3, DHFR, FOLR1, CCND1
39	paraffin⁴⁴	8.0	RB1, TP53, CDKN2A, EZR, PDGFRA, CCND1
40	thymidine⁴⁴ ²⁵	9.0	RB1, CCND1, MTHFR, TP53, IGF1, TYMS
41	arginine⁴⁴	7.9	FAS, TYMS, IGFBP3, IGF1, TP53, RFC1
42	methotrexate⁵⁰ ⁴⁴ ¹²	9.9	TYMS, IGFBP3, SHMT1, DHFR, FOLR1, CCND1
43	vegf⁴⁴	7.9	RB1, IGFBP3, IGF1, TP53, FAS, CCND1
44	paclitaxel⁴⁴ ⁵⁰ ¹²	9.7	SLC19A1, CDKN2A, RB1, TWIST1, CCND1, FOLR1
45	doxorubicin⁴⁴ ⁵⁰ ¹²	9.7	TYMS, MTR, IGFBP3, TP53, FAS, DHFR
46	retinoic acid⁴⁴ ²⁵	8.6	RB1, PDGFRA, CCND1, TP53, FAS, IGF1
47	thymidylate⁴⁴	7.5	DHFR, SLC19A1, FOLR1, CCND1, MTHFR, MTR
48	cisplatin⁴⁴ ⁵⁰ ⁶⁰ ¹²	10.4	TYMS, IGFBP3, TP53, SLC19A1, CDKN2A, RB1
49	estrogen⁴⁴	6.9	TWIST1, EZR, IGFBP3, IGF1, TP53, DHFR
50	serine⁴⁴	6.3	TP53, EZR, SHMT1, IGF1, IGFBP3, TYMS

GO Terms for genes affiliated with Pediatric Osteosarcoma

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Pediatric Osteosarcoma according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	insulin-like growth factor binding protein complex	GO:016942	9.8	IGFBP3, IGF1
2	nucleoplasm	GO:005654	8.1	RB1, TYMS, TP53, CDKN2A, CCND1, RFC1
3	cytosol	GO:005829	7.4	FAS, CDKN2A, TYMS, SHMT1, EZR, TP53
4	nucleus	GO:005634	6.6	CDKN2A, TP53, FAS, SHMT1, IGFBP3, TYMS

Biological processes related to Pediatric Osteosarcoma according to GeneCards/GeneDecks:

(show all 23)

id	Name	GO ID	Score	Top Affiliating Genes
1	folic acid transport	GO:015884	10.4	FOLR1, SLC19A1
2	tetrahydrofolate interconversion	GO:035999	10.3	SHMT1, MTHFR
3	response to folic acid	GO:051593	10.2	TYMS, MTHFR
4	positive regulation of insulin-like growth factor receptor signaling pathway	GO:043568	10.1	IGFBP3, IGF1
5	Leydig cell differentiation	GO:033327	10.1	PDGFRA, CCND1
6	mitotic G1 DNA damage checkpoint	GO:031571	10.0	CCND1, TP53
7	folic acid metabolic process	GO:046655	9.9	MTHFR, SHMT1, FOLR1, SLC19A1
8	replicative senescence	GO:090399	9.9	CDKN2A, TP53
9	cell cycle checkpoint	GO:000075	9.9	CDKN2A, RB1
10	myoblast differentiation	GO:045445	9.9	RB1, IGF1
11	water-soluble vitamin metabolic process	GO:006767	9.9	MTR, MTHFR, SHMT1, SLC19A1
12	vitamin metabolic process	GO:006766	9.9	SHMT1, MTHFR, MTR, SLC19A1
13	regulation of transcription involved in G1/S transition of mitotic cell cycle	GO:000083	9.8	RB1, TYMS
14	phosphatidylinositol-mediated signaling	GO:048015	9.7	TYMS, IGF1, PDGFRA
15	positive regulation of cell cycle arrest	GO:071158	9.5	CDKN2A, TP53
16	G1/S transition of mitotic cell cycle	GO:000082	9.4	CDKN2A, RB1, CCND1, TYMS
17	response to X-ray	GO:010165	9.4	CCND1, TP53
18	cell cycle arrest	GO:007050	9.3	CDKN2A, RB1, TP53
19	Ras protein signal transduction	GO:007265	9.3	IGF1, TP53, RB1, CDKN2A
20	negative regulation of cell proliferation	GO:008285	9.2	IGFBP3, IGF1, CDKN2A, TP53
21	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.9	TWIST1, TP53, IGF1, CDKN2A, RB1
22	mitotic cell cycle	GO:000278	8.9	CDKN2A, TYMS, RFC1, CCND1, RB1
23	positive regulation of transcription, DNA-templated	GO:045893	8.7	RFC1, TP53, IGF1, RB1, CDKN2A

Molecular functions related to Pediatric Osteosarcoma according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	folic acid binding	GO:005542	9.9	SLC19A1, FOLR1, TYMS
2	folic acid transporter activity	GO:008517	9.8	FOLR1, SLC19A1
3	MDM2/MDM4 family protein binding	GO:097371	9.5	CDKN2A, TP53
4	transcription factor binding	GO:008134	8.7	CDKN2A, RB1, TWIST1, CCND1, TP53
5	protein binding	GO:005515	6.4	IGFBP3, RB1, PDGFRA, TWIST1, CCND1, FAS

Products for genes affiliated with Pediatric Osteosarcoma

Antibodies
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Antibodies
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Kits and Assays

Sources for Pediatric Osteosarcoma

¹antibodies-online

²BioGPS

³BitterDB

⁴CDC

⁵Cell Signaling Technology

⁶ClinicalTrials

⁷Clinvar

⁸dbSNP

⁹Disease Ontology

¹⁰diseasecard

¹¹DISEASES

¹²DrugBank

¹³EMD Millipore

¹⁴ExPASy

¹⁵FMA

¹⁶Gene Expression Omnibus DataSets

¹⁷Gene Ontology

¹⁸GeneCards

¹⁹GeneDecks

²⁰GeneReviews

²¹GeneTests

²²Genetics Home Reference

²³GTR

²⁴HGMD

²⁵HMDB

²⁶ICD10

²⁷ICD10 via Orphanet

²⁸ICD9CM

²⁹IUPHAR

³⁰KEGG

³¹LifeMap Discovery®

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PathCards

⁵⁰PharmGKB

⁵¹PubMed

⁵²QIAGEN

⁵³R&D Systems

⁵⁴Reactome

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸The Human Phenotype Ontology

⁵⁹Thomson Reuters

⁶⁰Tocris Bioscience

⁶¹UMLS

⁶²UMLS via Orphanet

⁶³UniProtKB/Swiss-Prot

⁶⁴Wikipedia

MCID: PDT021 MIFTS: 48	Pediatric Osteosarcoma malady Cancer diseases, Bone diseases categories
20 genes, 1 tissue, 91 related diseases, clinical trials Download this MalaCard Expand all tables

Pediatric Osteosarcoma malady