MCID: PDT021
MIFTS: 48

Pediatric Osteosarcoma malady

Cancer diseases, Bone diseases categories
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Summaries for Pediatric Osteosarcoma

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33MalaCards
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Fully expand this MalaCard
MalaCards: Pediatric Osteosarcoma, also known as childhood osteosarcoma, is related to osteosarcoma and sarcoma. An important gene associated with Pediatric Osteosarcoma is FOLR1 (folate receptor 1 (adult)), and among its related pathways are Methotrexate Pathway, Pharmacokinetics and folate polyglutamylation. The compounds ag 331 and metoprine have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are pigmentation and craniofacial.

Aliases & Classifications for Pediatric Osteosarcoma

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8Disease Ontology, 62UMLS, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Bone diseases


Aliases & Descriptions:

pediatric osteosarcoma 8
childhood osteosarcoma 62


External Ids:

Disease Ontology8 DOID:3361
NCIt40 C6585

Related Diseases for Pediatric Osteosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Pediatric Osteosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1osteosarcoma30.9FAS, TWIST1, PDGFRA, RB1, CDKN2A, SLC19A1
2sarcoma30.2TP53, PDGFRA, TWIST1, EZR, FOLR1, RB1
3myelomeningocele10.1MTHFR
4adult acute lymphocytic leukemia10.1SHMT1, TYMS
5homocysteinemia10.1MTR, MTHFR
6homocysteinemia due to mthfr deficiency10.1MTR, MTHFR
7anencephaly10.1MTHFR, FOLR1
8megaloblastic anemia10.1MTR, MTHFR
9acromegaly10.1IGFBP3, IGF1
10insulin-like growth factor 1 resistance to10.1IGF1, IGFBP3
11nutritional deficiency disease10.1MTHFR, IGFBP3
12methylmalonic acidemia10.1MTR, MTHFR
13rabson-mendenhall syndrome10.1IGFBP3, IGF1
14idiopathic juvenile osteoporosis10.1IGF1, IGFBP3
15vitamin b12 deficiency10.1MTHFR, MTR
16actinic keratosis10.1TP53
17cleft lip10.1SLC19A1, MTR, MTHFR
18laron syndrome10.1IGF1, IGFBP3
19colon adenocarcinoma10.1TYMS, FOLR1, FAS
20anovulation10.1IGF1, IGFBP3
21growth retardation-mild developmental delay-chronic hepatitis syndrome10.1IGFBP3, IGF1
22cleft palate10.1SLC19A1, MTHFR, MTR, TWIST1
23anaplastic oligodendroglioma10.1PDGFRA, CDKN2A
24hyperhomocysteinemia10.1TYMS, MTHFR, MTR, SLC19A1
25li-fraumeni syndrome10.0TP53, CDKN2A
26benign mesothelioma10.0TP53, TYMS
27noonan syndrome10.0IGFBP3, IGF1
28down syndrome10.0SLC19A1, MTR, MTHFR
29osteochondroma10.0
30oropharyngeal cancer, adult10.0CDKN2A, TP53
31precursor t-cell acute lymphoblastic leukemia10.0TYMS, DHFR, CDKN2A, SLC19A1
32immunodeficiency with hyper igm type 210.0DHFR, MTR, TYMS, EZR
33ependymoma10.0EZR, PDGFRA, RB1
34chronic kidney failure10.0IGF1, MTR, IGFBP3, MTHFR
35gallbladder cancer10.0TP53, TYMS
36cervical intraepithelial neoplasia10.0RB1, CDKN2A, MTHFR
37nasopharynx carcinoma10.0CDKN2A, TP53
38folic acid deficiency anemia10.0SLC19A1, MTR, MTHFR, FOLR1, DHFR, TYMS
39spina bifida10.0PDGFRA, MTR, MTHFR, DHFR, FOLR1, SLC19A1
40acute lymphoblastic leukemia, childhood10.0SLC19A1, CDKN2A, DHFR, MTHFR, TYMS
41neural tube defects10.0TYMS, SLC19A1, PDGFRA, MTR, MTHFR, SHMT1
42leiomyosarcoma10.0RB1, TP53, PDGFRA
43ductal carcinoma in situ10.0CCND1, TP53
44medulloblastoma10.0DHFR, PDGFRA, TP53, EZR
45barrett's esophagus10.0TP53, CCND1, CDKN2A
46rheumatoid arthritis10.0FAS, EZR, MTHFR, DHFR, SLC19A1
47bladder carcinoma in situ10.0CCND1, CDKN2A, TP53
48pancreatic cancer10.0CDKN2A, FAS, TYMS
49esophageal cancer10.0CDKN2A, CCND1, TP53
50laryngeal benign neoplasm10.0TP53, CCND1, RB1

Graphical network of the top 20 diseases related to Pediatric Osteosarcoma:



Diseases related to pediatric osteosarcoma

Symptoms for Pediatric Osteosarcoma

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Drugs & Therapeutics for Pediatric Osteosarcoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Pediatric Osteosarcoma

Search NIH Clinical Center for Pediatric Osteosarcoma

Genetic Tests for Pediatric Osteosarcoma

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Anatomical Context for Pediatric Osteosarcoma

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33MalaCards
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MalaCards organs/tissues related to Pediatric Osteosarcoma:

33
Bone

Animal Models for Pediatric Osteosarcoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Pediatric Osteosarcoma:

37 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.9TP53, FAS, PDGFRA, RB1, CDKN2A
2MP:00053828.6RB1, PDGFRA, TWIST1, CCND1, FOLR1, FAS
3MP:00053718.5IGF1, TP53, FAS, MTHFR, TWIST1, PDGFRA
4MP:00053708.5IGFBP3, SHMT1, TP53, FAS, RB1, CDKN2A
5MP:00053918.3TP53, FAS, FOLR1, CCND1, MTHFR, RB1
6MP:00053698.3IGFBP3, IGF1, TP53, TWIST1, PDGFRA, RB1
7MP:00053888.2IGF1, TP53, FAS, CCND1, PDGFRA, RB1
8MP:00053858.2TP53, FAS, CCND1, TWIST1, PDGFRA, RB1
9MP:00020068.0IGF1, SHMT1, TP53, FAS, FOLR1, CCND1
10MP:00053808.0EZR, TP53, FOLR1, TWIST1, PDGFRA, RB1
11MP:00053907.8IGF1, TP53, FAS, CCND1, MTHFR, TWIST1
12MP:00107717.8IGF1, TP53, FAS, CCND1, MTHFR, PDGFRA
13MP:00053897.8IGF1, TP53, FAS, CCND1, MTHFR, PDGFRA
14MP:00053977.7IGF1, TP53, FAS, CCND1, PDGFRA, RB1
15MP:00053797.7IGFBP3, IGF1, TP53, FAS, FOLR1, CCND1
16MP:00053847.7IGF1, TP53, FAS, FOLR1, CCND1, TWIST1
17MP:00036317.6IGF1, TP53, FAS, CDKN2A, RB1, PDGFRA
18MP:00053867.6IGFBP3, TP53, FAS, CCND1, TWIST1, PDGFRA
19MP:00053817.5EZR, TP53, FAS, FOLR1, CCND1, TWIST1
20MP:00053877.3IGF1, EZR, TP53, FAS, CCND1, PDGFRA
21MP:00053786.6FAS, TP53, EZR, IGF1, IGFBP3, FOLR1
22MP:00107686.4FOLR1, FAS, TP53, EZR, SHMT1, IGF1
23MP:00053766.4SLC19A1, IGFBP3, IGF1, SHMT1, EZR, TP53

Publications for Pediatric Osteosarcoma

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52PubMed
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Articles related to Pediatric Osteosarcoma:

(show top 50)    (show all 52)
idTitleAuthorsYear
1
Upregulated expression of microRNA-214 is linked to tumor progression and adverse prognosis in pediatric osteosarcoma. (24038809)
2014
2
Endothelin-1 gene polymorphisms and risk of chemoresistant pediatric osteosarcoma. (24123836)
2013
3
Pathological fracture as the presenting feature in pediatric osteosarcoma. (23281226)
2013
4
Bronchioloalveolar carcinoma as a second malignancy in a pediatric osteosarcoma survivor: case report. (23758793)
2013
5
Combined MicroRNA-340 and ROCK1 mRNA Profiling Predicts Tumor Progression and Prognosis in Pediatric Osteosarcoma. (24398981)
2013
6
Carboplatin and doxorubicin in treatment of pediatric osteosarcoma: a 9-year single institute experience in the Northern Region of Thailand. (23621194)
2013
7
Clinical relations of methotrexate pharmacokinetics in the treatment for pediatric osteosarcoma. (22652833)
2012
8
Case-parent analysis of variation in pubertal hormone genes and pediatric osteosarcoma: a Children's Oncology Group (COG) study. (23205180)
2012
9
Plasma proteomic profiling of pediatric osteosarcoma. (22083817)
2012
10
Correlation of non-mass-like abnormal MR signal intensity with pathological findings surrounding pediatric osteosarcoma and Ewing's sarcoma. (22406919)
2012
11
Serum tumor markers in pediatric osteosarcoma: a summary review. (22587902)
2012
12
Location of pulmonary metastasis in pediatric osteosarcoma is predictive of outcome. (21763830)
2011
13
Primary pediatric osteosarcoma of the skull. (22134292)
2011
14
Elevated expression of CXC chemokines in pediatric osteosarcoma patients. (20806347)
2011
15
Two pediatric osteosarcoma cases with delayed methotrexate excretion: its clinical course and management. (21509165)
2011
16
Survival outcomes of pediatric osteosarcoma and Ewing's sarcoma: a comparison of surgery type within the SEER database, 1988-2007. (22223058)
2011
17
Staged lengthening arthroplasty for pediatric osteosarcoma around the knee. (19885713)
2010
18
Lengthening of intercalary allograft combined with free vascularized fibular graft after reconstruction in pediatric osteosarcoma of femur. (19950438)
2010
19
Prognostic significance of early lymphocyte recovery in pediatric osteosarcoma. (20734401)
2010
20
Proteomic analysis of chemonaive pediatric osteosarcomas and corresponding normal bone reveals multiple altered molecular targets. (19492781)
2009
21
Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression. (19159907)
2009
22
Clinical characteristics and treatment results of pediatric osteosarcoma: the role of high dose chemotherapy with autologous stem cell transplantation. (19688126)
2008
23
Treatment results of pediatric osteosarcoma: twenty-year experience. (17314654)
2007
24
Exploratory analysis of Fas gene polymorphisms in pediatric osteosarcoma patients. (18090928)
2007
25
The cause and clinical significance of central tumor photopenia on thallium scintigraphy of pediatric osteosarcoma of the extremity. (17242270)
2007
26
Toxicity prevention with amifostine in pediatric osteosarcoma patients treated with cisplatin and doxorubicin. (17710657)
2007
27
KIT gene in pediatric osteosarcomas: could it be a new therapeutic target? (17294449)
2007
28
Identification of a plasma proteomic signature to distinguish pediatric osteosarcoma from benign osteochondroma. (16673437)
2006
29
Tumor necrosis in pediatric osteosarcoma: impact of modern therapies. (16766682)
2006
30
An expression signature classifies chemotherapy-resistant pediatric osteosarcoma. (15753370)
2005
31
Pediatric osteosarcoma: a 35-year experience in Slovenia. (16020121)
2005
32
Frequent genomic abnormalities at TWIST in human pediatric osteosarcomas. (15900593)
2005
33
Improved survival in primary nonmetastatic pediatric osteosarcoma of the extremity. (16131881)
2005
34
HER2 amplification and overexpression is not present in pediatric osteosarcoma: a tissue microarray study. (16211448)
2005
35
Biology and therapeutic advances for pediatric osteosarcoma. (15266096)
2004
36
Superior survival in treatment of primary nonmetastatic pediatric osteosarcoma of the extremity. (12794015)
2003
37
Genetic and epigenetic alterations of the cell cycle regulators and tumor suppressor genes in pediatric osteosarcomas. (12759621)
2003
38
High-resolution mapping of amplifications and deletions in pediatric osteosarcoma by use of CGH analysis of cDNA microarrays. (14506695)
2003
39
Loss of p16(INK4a) expression correlates with decreased survival in pediatric osteosarcomas. (11241308)
2001
40
Dynamic magnetic resonance imaging of regional contrast access as an additional prognostic factor in pediatric osteosarcoma. (11413510)
2001
41
Circulating concentrations of IGF-I and IGFBP-3 are not predictive of incidence or clinical behavior of pediatric osteosarcoma. (11344491)
2001
42
Neoadjuvant chemotherapy for pediatric osteosarcoma patients. (9010116)
1997
43
NCCN pediatric osteosarcoma practice guidelines. The National Comprehensive Cancer Network. (8985965)
1996
44
Mutational activation of ras genes is absent in pediatric osteosarcoma. (7850751)
1995
45
Pediatric osteosarcoma - treatment of the primary tumor with intravenous cis-diamminedichloroplatinum-ii (cdp) - comparison of the results with the reported efficacy of intraarterial cdp. (21573359)
1993
46
Pediatric osteosarcoma: treatment of the primary tumor with intraarterial cis-diamminedichloroplatinum-II (CDP)--advantages, disadvantages, and controversial issues. (8096762)
1993
47
Development and characterization of pediatric osteosarcoma xenografts. (2328504)
1990
48
Pediatric osteosarcoma. Successful retreatment of relapsed primary tumor and soft tissue recurrence with intraarterial cis-diamminedichloroplatin-II. (2386906)
1990
49
Pediatric osteosarcoma: therapeutic strategies, results, and prognostic factors derived from a 10-year experience. (2230890)
1990
50
Auditory function in pediatric osteosarcoma patients treated with multiple doses of cis-diamminedichloroplatinum(II). (2910492)
1989

Variations for Pediatric Osteosarcoma

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Expression for genes affiliated with Pediatric Osteosarcoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pediatric Osteosarcoma

Search GEO for disease gene expression data for Pediatric Osteosarcoma.

Pathways for genes affiliated with Pediatric Osteosarcoma

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Sources:
50PathCards, 51PharmGKB, 38NCBI BioSystems Database, 55Reactome, 30KEGG, 60Thomson Reuters, 53QIAGEN, 12EMD Millipore, 57SinoBiological, 5Cell Signaling Technology
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Pathways related to Pediatric Osteosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.1SLC19A1, FOLR1
2
Show member pathways
Glycine Metabolism38
glycine biosynthesis I38
folate transformations38
10.1SHMT1, MTR
39.9IGF1, IGFBP3
4
Show member pathways
L-serine degradation38
pentose phosphate pathway (oxidative branch)38
formaldehyde oxidation II (glutathione-dependent)38
9.8SHMT1, MTHFR, MTR
5
Show member pathways
9.6CDKN2A, TP53
69.6TYMS, DHFR, RB1
7
Show member pathways
FAS pathway and Stress induction of HSP regulation38
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis38
9.5RB1, FAS, IGF1
8
Show member pathways
Signal transduction PTEN pathway60
9.4CCND1, TP53, IGF1
9
Show member pathways
9.4IGF1, TP53, CCND1
10
Show member pathways
flavin biosynthesis IV (mammalian)38
molybdenum cofactor biosynthesis38
coenzyme A biosynthesis38
thiamin salvage III38
alanine biosynthesis III38
thio-molybdenum cofactor biosynthesis38
biotin-carboxyl carrier protein assembly38
9.3SHMT1, DHFR, MTHFR, MTR, SLC19A1
11
Show member pathways
One Carbon Metabolism38
dTMP de novo biosynthesis (mitochondrial)38
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate38
Trans-sulfuration and one carbon metabolism38
methionine salvage38
Methionine metabolism60
9.3TYMS, SHMT1, DHFR, MTHFR, MTR
129.3RB1, TWIST1, FAS, IGF1
139.3TP53, CCND1, RB1
149.3TP53, CCND1, RB1
15
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
9.3TP53, CCND1, RB1
16
Show member pathways
9.3TYMS, TP53, DHFR, MTHFR
179.2TP53, RB1, CDKN2A
189.2TP53, RB1, CDKN2A
19
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.2CCND1, EZR, IGF1
209.2MIR210, CCND1, TP53
21
Show member pathways
Integrin-mediated cell adhesion38
Focal Adhesion38
9.1RB1, PDGFRA, CCND1, IGF1
229.1PDGFRA, CCND1, TP53, IGF1
239.1SHMT1, DHFR, MTHFR, MTR, PDGFRA, SLC19A1
24
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.1IGFBP3, IGF1, TP53, CCND1
25
Show member pathways
TRAIL signaling pathway38
9.1FAS, RFC1, EZR
269.1IGFBP3, TP53, FAS, RB1
27
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
9.1IGF1, TP53, FAS, CDKN2A
28
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.0RB1, CCND1, FAS, TP53
29
Show member pathways
9.0RB1, CCND1, FAS, TP53
30
Show member pathways
8.9TP53, CCND1, RB1, CDKN2A
31
Show member pathways
Cell cycle38
8.9CDKN2A, RB1, CCND1, TP53
32
Show member pathways
8.9CDKN2A, RB1, CCND1, TP53
338.9CDKN2A, RB1, CCND1, TP53
348.8TYMS, TP53, DHFR, CCND1, RB1
35
Show member pathways
8.7IGF1, TP53, PDGFRA, RB1, CDKN2A
36
Show member pathways
8.6TYMS, TP53, CCND1, RB1, CDKN2A
378.6CDKN2A, RB1, PDGFRA, CCND1, TP53
388.6IGFBP3, IGF1, TP53, RB1, CDKN2A
39
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
8.5TP53, RFC1, FAS, CCND1, RB1
40
Show member pathways
8.4TYMS, TP53, DHFR, CCND1, RB1, CDKN2A
41
Show member pathways
8.3IGF1, TP53, CCND1, PDGFRA, RB1, CDKN2A
42
Show member pathways
Signaling Pathways in Glioblastoma38
8.3IGF1, TP53, CCND1, PDGFRA, RB1, CDKN2A
438.3IGF1, TP53, CCND1, PDGFRA, RB1, CDKN2A
44
Show member pathways
8.3IGF1, TP53, CCND1, PDGFRA, RB1, CDKN2A
458.3TYMS, IGFBP3, IGF1, TP53, FAS, CCND1
468.3IGF1, EZR, TP53, FAS, CCND1, TWIST1
478.0IGF1, TP53, FAS, CCND1, PDGFRA, RB1
48
Show member pathways
7.9TYMS, TP53, RFC1, DHFR, CCND1, RB1
49
Show member pathways
DNA damage response38
7.5CDKN2A, IGFBP3, IGF1, TP53, RFC1, FAS
507.1EZR, TP53, CCND1, MIR214, MIR210, PDGFRA

Compounds for genes affiliated with Pediatric Osteosarcoma

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Sources:
45Novoseek, 11DrugBank, 24HMDB, 51PharmGKB, 61Tocris Bioscience
See all sources

Compounds related to Pediatric Osteosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 199)
idCompoundScoreTop Affiliating Genes
1ag 3314510.1SLC19A1, TYMS, DHFR
2metoprine4510.0SLC19A1, DHFR, TYMS
3ag 3374510.0SLC19A1, TYMS, DHFR
4pt5234510.0SLC19A1, DHFR, TYMS
55-methyltetrahydrofolate45 1110.9FOLR1, SLC19A1, MTR, MTHFR
6b vitamins459.9TYMS, SHMT1, MTHFR, MTR
710-formyltetrahydrofolate459.9SLC19A1, MTR, DHFR, MTHFR
8Tetrahydrofolic acid24 1110.8SHMT1, MTR, DHFR, MTHFR
9ag 2034459.8DHFR, SLC19A1, TYMS
10folic acid51 24 1111.7MTHFR, SLC19A1, DHFR, FOLR1
11trimetrexate45 1110.7TYMS, DHFR, FOLR1, SLC19A1, CDKN2A
12tomudex459.6SLC19A1, FOLR1, TP53, TYMS, DHFR
13leucovorin45 51 1111.5FOLR1, MTHFR, SLC19A1, DHFR, TYMS, SHMT1
14tetrahydrofolate459.5MTHFR, TYMS, SLC19A1, MTR, DHFR, SHMT1
15vitamin b12459.4IGF1, MTR, MTHFR, TYMS, IGFBP3
16fluorouracil51 1110.2MTHFR, SHMT1, TP53, SLC19A1, TYMS, CCND1
17purine45 2410.1SLC19A1, DHFR, SHMT1, CDKN2A, TYMS, MTHFR
18valine459.1DHFR, MTR, IGFBP3, CDKN2A, MTHFR, TYMS
19irinotecan45 51 1111.1MTHFR, SLC19A1, TYMS, SHMT1, CDKN2A, TP53
20olomoucine45 1110.0RB1, CDKN2A, TP53, CCND1
215-aza-2deoxycytidine459.0TP53, SLC19A1, IGFBP3, FAS, FOLR1, CDKN2A
22n-(4-hydroxyphenyl)retinamide459.0CCND1, RB1, TP53, IGFBP3, IGF1
23depsipeptide459.0RB1, TP53, FAS, CCND1, CDKN2A
24carboplatin45 51 1110.9MTHFR, TP53, RB1, SLC19A1, TYMS
25mitomycin c458.9TYMS, FAS, DHFR, RB1, TP53
26cytarabine45 51 1110.9RB1, TYMS, CDKN2A, DHFR, FAS, TP53
27vincristine45 51 1110.8MTR, CDKN2A, SLC19A1, CCND1, TP53, RB1
28hydroxyurea45 51 1110.8TYMS, TP53, DHFR, PDGFRA, CDKN2A
29egcg458.7TP53, IGFBP3, CCND1, RB1, CDKN2A, FAS
30etoposide45 51 61 1111.7TP53, FAS, DHFR, TYMS, IGFBP3, IGF1
31gemcitabine45 51 1110.6CCND1, DHFR, MTHFR, TP53, TYMS
32dihydrofolate458.6DHFR, SHMT1, TYMS, SLC19A1, FOLR1, MTR
33butyrate458.3TYMS, TP53, FAS, DHFR, IGFBP3, CDKN2A
34adriamycin458.3IGF1, TP53, FAS, DHFR, TYMS, CDKN2A
35cysteine458.2TYMS, RB1, IGFBP3, FAS, DHFR, MTHFR
365fluorouracil458.1CDKN2A, SLC19A1, MTHFR, DHFR, TP53, RB1
37ly294002458.1IGF1, TP53, IGFBP3, EZR, FAS, CCND1
38folate458.1CDKN2A, TYMS, IGFBP3, DHFR, FOLR1, CCND1
39paraffin458.0RB1, TP53, CDKN2A, EZR, PDGFRA, CCND1
40thymidine45 249.0RB1, CCND1, MTHFR, TP53, IGF1, TYMS
41arginine457.9FAS, TYMS, IGFBP3, IGF1, TP53, RFC1
42methotrexate51 45 119.9TYMS, IGFBP3, SHMT1, DHFR, FOLR1, CCND1
43vegf457.9RB1, IGFBP3, IGF1, TP53, FAS, CCND1
44paclitaxel45 51 119.7SLC19A1, CDKN2A, RB1, TWIST1, CCND1, FOLR1
45doxorubicin45 51 119.7TYMS, MTR, IGFBP3, TP53, FAS, DHFR
46retinoic acid45 248.6RB1, PDGFRA, CCND1, TP53, FAS, IGF1
47thymidylate457.5DHFR, SLC19A1, FOLR1, CCND1, MTHFR, MTR
48cisplatin45 51 61 1110.4TYMS, IGFBP3, TP53, SLC19A1, CDKN2A, RB1
49estrogen456.9TWIST1, EZR, IGFBP3, IGF1, TP53, DHFR
50serine456.3TP53, EZR, SHMT1, IGF1, IGFBP3, TYMS

GO Terms for genes affiliated with Pediatric Osteosarcoma

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Sources:
16Gene Ontology
See all sources

Cellular components related to Pediatric Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor binding protein complexGO:0169429.8IGFBP3, IGF1
2nucleoplasmGO:0056548.1TP53, RFC1, CCND1, RB1, CDKN2A, TYMS
3cytosolGO:0058297.4CDKN2A, TYMS, SHMT1, EZR, TP53, FAS
4nucleusGO:0056346.6TYMS, IGFBP3, SHMT1, TP53, RFC1, FAS

Biological processes related to Pediatric Osteosarcoma according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1folic acid transportGO:01588410.4SLC19A1, FOLR1
2tetrahydrofolate interconversionGO:03599910.3MTHFR, SHMT1
3response to folic acidGO:05159310.2TYMS, MTHFR
4positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.1IGF1, IGFBP3
5Leydig cell differentiationGO:03332710.1PDGFRA, CCND1
6mitotic G1 DNA damage checkpointGO:03157110.0TP53, CCND1
7folic acid metabolic processGO:0466559.9SLC19A1, MTHFR, FOLR1, SHMT1
8cell cycle checkpointGO:0000759.9RB1, CDKN2A
9replicative senescenceGO:0903999.9CDKN2A, TP53
10myoblast differentiationGO:0454459.9IGF1, RB1
11water-soluble vitamin metabolic processGO:0067679.9SHMT1, MTHFR, MTR, SLC19A1
12vitamin metabolic processGO:0067669.9SLC19A1, MTR, MTHFR, SHMT1
13regulation of transcription involved in G1/S transition of mitotic cell cycleGO:0000839.8RB1, TYMS
14phosphatidylinositol-mediated signalingGO:0480159.7TYMS, IGF1, PDGFRA
15positive regulation of cell cycle arrestGO:0711589.5CDKN2A, TP53
16G1/S transition of mitotic cell cycleGO:0000829.4TYMS, CCND1, RB1, CDKN2A
17response to X-rayGO:0101659.4CCND1, TP53
18cell cycle arrestGO:0070509.3CDKN2A, RB1, TP53
19Ras protein signal transductionGO:0072659.3IGF1, TP53, RB1, CDKN2A
20negative regulation of cell proliferationGO:0082859.2CDKN2A, TP53, IGF1, IGFBP3
21positive regulation of transcription from RNA polymerase II promoterGO:0459448.9IGF1, TP53, TWIST1, RB1, CDKN2A
22mitotic cell cycleGO:0002788.9CDKN2A, RB1, CCND1, RFC1, TYMS
23positive regulation of transcription, DNA-templatedGO:0458938.7IGF1, TP53, RFC1, RB1, CDKN2A

Molecular functions related to Pediatric Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1folic acid bindingGO:0055429.9SLC19A1, FOLR1, TYMS
2folic acid transporter activityGO:0085179.8FOLR1, SLC19A1
3MDM2/MDM4 family protein bindingGO:0973719.5CDKN2A, TP53
4transcription factor bindingGO:0081348.7TP53, CCND1, TWIST1, RB1, CDKN2A
5protein bindingGO:0055156.4IGF1, EZR, TP53, RFC1, FAS, CCND1

Products for genes affiliated with Pediatric Osteosarcoma

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Sources for Pediatric Osteosarcoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet