MCID: PDT021
MIFTS: 41

Pediatric Osteosarcoma malady

Bone diseases category

Aliases & Classifications for Pediatric Osteosarcoma

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Aliases & Descriptions for Pediatric Osteosarcoma:

Name: Pediatric Osteosarcoma 8
 
Childhood Osteosarcoma 61


Classifications:



External Ids:

Disease Ontology8 DOID:3361
NCIt39 C6585

Summaries for Pediatric Osteosarcoma

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MalaCards based summary: Pediatric Osteosarcoma, also known as childhood osteosarcoma, is related to sarcoma and myelomeningocele. An important gene associated with Pediatric Osteosarcoma is FOLR1 (folate receptor 1 (adult)), and among its related pathways are Methotrexate Pathway, Pharmacokinetics and folate polyglutamylation. The compounds ag 331 and metoprine have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are pigmentation and craniofacial.

Related Diseases for Pediatric Osteosarcoma

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Diseases related to Pediatric Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma29.8EZR, TP53, DHFR, FOLR1, TWIST1, PDGFRA
2myelomeningocele10.5MTHFR
3adult acute lymphocytic leukemia10.5SHMT1, TYMS
4homocysteinemia10.4MTR, MTHFR
5homocysteinemia due to mthfr deficiency10.4MTHFR, MTR
6anencephaly10.4MTHFR, FOLR1
7megaloblastic anemia10.3MTHFR, MTR
8pituitary gigantism10.3IGFBP3, IGF1
9insulin-like growth factor 1 resistance to10.3IGFBP3, IGF1
10nutritional deficiency disease10.3MTHFR, IGFBP3
11methylmalonic acidemia10.3MTHFR, MTR
12rabson-mendenhall syndrome10.3IGF1, IGFBP3
13actinic keratosis10.3TP53
14idiopathic juvenile osteoporosis10.3IGFBP3, IGF1
15vitamin b12 deficiency10.3MTR, MTHFR
16cleft lip10.3SLC19A1, MTR, MTHFR
17laron dwarfism10.3IGFBP3, IGF1
18tonsil squamous cell carcinoma10.3CCND1, CDKN2A
19colon adenocarcinoma10.3TYMS, FAS, FOLR1
20anovulation10.2IGF1, IGFBP3
21cleft palate, isolated10.2MTHFR, MTR, TWIST1, SLC19A1
22hyperhomocysteinemia10.2TYMS, MTHFR, MTR, SLC19A1
23anaplastic oligodendroglioma10.2PDGFRA, CDKN2A
24gallbladder adenoma10.2RB1, CDKN2A
25noonan syndrome 110.2IGFBP3, IGF1
26li-fraumeni syndrome10.2TP53, CDKN2A
27down syndrome10.2SLC19A1, MTR, MTHFR
28benign mesothelioma10.2TYMS, TP53
29oropharynx cancer10.2TP53, CDKN2A
30precursor t-cell acute lymphoblastic leukemia10.2SLC19A1, CDKN2A, DHFR, TYMS
31hiv-110.1MTR, DHFR, EZR, TYMS
32ependymoma10.1EZR, PDGFRA, RB1
33mesothelioma10.1TYMS, DHFR, FOLR1, CDKN2A, SLC19A1
34chronic kidney failure10.1IGFBP3, IGF1, MTHFR, MTR
35nasopharynx carcinoma10.1TP53, CDKN2A
36cervical intraepithelial neoplasia10.1MTHFR, RB1, CDKN2A
37gallbladder cancer10.1TYMS, TP53
38folic acid deficiency anemia10.1SLC19A1, MTR, MTHFR, FOLR1, DHFR, TYMS
39neural tube defects10.1DHFR, FOLR1, MTHFR, MTR, PDGFRA, SLC19A1
40osteochondroma10.1
41acute lymphoblastic leukemia, childhood10.0TYMS, DHFR, MTHFR, CDKN2A, SLC19A1
42leiomyosarcoma10.0TP53, PDGFRA, RB1
43ductal carcinoma in situ10.0CCND1, TP53
44medulloblastoma10.0EZR, TP53, DHFR, PDGFRA
45barrett esophagus/esophageal adenocarcinoma10.0CDKN2A, CCND1, TP53
46rheumatoid arthritis10.0EZR, FAS, DHFR, MTHFR, SLC19A1
47pancreatic cancer10.0TYMS, FAS, CDKN2A
48esophageal cancer10.0TP53, CCND1, CDKN2A
49laryngeal carcinoma10.0TP53, CCND1, RB1
50bladder cancer, somatic9.9TP53, RB1, CDKN2A

Graphical network of the top 20 diseases related to Pediatric Osteosarcoma:



Diseases related to pediatric osteosarcoma

Symptoms for Pediatric Osteosarcoma

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Drugs & Therapeutics for Pediatric Osteosarcoma

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Drug clinical trials:

Search ClinicalTrials for Pediatric Osteosarcoma

Search NIH Clinical Center for Pediatric Osteosarcoma

Genetic Tests for Pediatric Osteosarcoma

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Anatomical Context for Pediatric Osteosarcoma

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MalaCards organs/tissues related to Pediatric Osteosarcoma:

31
Bone

Animal Models for Pediatric Osteosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Pediatric Osteosarcoma:

35 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.9TP53, FAS, PDGFRA, RB1, CDKN2A
2MP:00053828.6FOLR1, TWIST1, PDGFRA, RB1, FAS, TP53
3MP:00053718.5IGF1, MTHFR, FAS, TP53, PDGFRA, RB1
4MP:00053708.5IGFBP3, CDKN2A, RB1, FAS, SHMT1, TP53
5MP:00053918.3TP53, CDKN2A, RB1, MTHFR, CCND1, FOLR1
6MP:00053698.3PDGFRA, IGFBP3, IGF1, TP53, TWIST1, RB1
7MP:00053888.2IGF1, RB1, CDKN2A, PDGFRA, CCND1, FAS
8MP:00053858.2FAS, CCND1, TWIST1, PDGFRA, RB1, IGF1
9MP:00020068.0CDKN2A, PDGFRA, CCND1, FOLR1, FAS, TP53
10MP:00053808.0FOLR1, TWIST1, CDKN2A, TP53, EZR, RB1
11MP:00053907.8TWIST1, IGF1, TP53, FAS, CCND1, MTHFR
12MP:00107717.8IGF1, TP53, FAS, CDKN2A, MTHFR, CCND1
13MP:00053897.8SLC19A1, FAS, CDKN2A, PDGFRA, MTHFR, CCND1
14MP:00053977.7SLC19A1, CDKN2A, RB1, CCND1, TP53, IGF1
15MP:00053797.7SLC19A1, IGFBP3, CDKN2A, RB1, PDGFRA, IGF1
16MP:00053847.7IGF1, RB1, FAS, FOLR1, CCND1, TWIST1
17MP:00036317.6IGF1, RB1, PDGFRA, MTHFR, CCND1, TWIST1
18MP:00053867.6IGFBP3, FAS, TWIST1, PDGFRA, RB1, CDKN2A
19MP:00053817.5EZR, TP53, FOLR1, CCND1, PDGFRA, FAS
20MP:00053877.3FAS, RB1, IGF1, TP53, CCND1, PDGFRA
21MP:00053786.6SLC19A1, CDKN2A, RB1, CCND1, PDGFRA, IGFBP3
22MP:00107686.4MTHFR, FOLR1, EZR, TP53, FAS, IGF1
23MP:00053766.4FAS, IGF1, CCND1, MTHFR, MTR, PDGFRA

Publications for Pediatric Osteosarcoma

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Articles related to Pediatric Osteosarcoma:

(show top 50)    (show all 61)
idTitleAuthorsYear
1
In silico functional analyses and discovery of survival-associated microRNA signatures in pediatric osteosarcoma. (25594070)
2014
2
Impaired testicular function after an ifosfamide-containing regimen for pediatric osteosarcoma: a case series and review of the literature. (24667129)
2014
3
Experience of Pediatric Osteosarcoma of the Extremity at a Single Institution in Taiwan: Prognostic Factors and Impact on Survival. (25323470)
2014
4
Management of local recurrence of pediatric osteosarcoma following limb-sparing surgery. (24558066)
2014
5
Pediatric Osteosarcoma: A Single Institution's Experience. (25365431)
2014
6
Upregulated expression of microRNA-214 is linked to tumor progression and adverse prognosis in pediatric osteosarcoma. (24038809)
2014
7
Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma. (24703847)
2014
8
Endothelin-1 gene polymorphisms and risk of chemoresistant pediatric osteosarcoma. (24123836)
2013
9
Pathological fracture as the presenting feature in pediatric osteosarcoma. (23281226)
2013
10
Bronchioloalveolar carcinoma as a second malignancy in a pediatric osteosarcoma survivor: case report. (23758793)
2013
11
Combined MicroRNA-340 and ROCK1 mRNA Profiling Predicts Tumor Progression and Prognosis in Pediatric Osteosarcoma. (24398981)
2013
12
Clinical relations of methotrexate pharmacokinetics in the treatment for pediatric osteosarcoma. (22652833)
2012
13
Case-parent analysis of variation in pubertal hormone genes and pediatric osteosarcoma: a Children's Oncology Group (COG) study. (23205180)
2012
14
Plasma proteomic profiling of pediatric osteosarcoma. (22083817)
2012
15
Correlation of non-mass-like abnormal MR signal intensity with pathological findings surrounding pediatric osteosarcoma and Ewing's sarcoma. (22406919)
2012
16
Location of pulmonary metastasis in pediatric osteosarcoma is predictive of outcome. (21763830)
2011
17
Primary pediatric osteosarcoma of the skull. (22134292)
2011
18
Elevated expression of CXC chemokines in pediatric osteosarcoma patients. (20806347)
2011
19
Two pediatric osteosarcoma cases with delayed methotrexate excretion: its clinical course and management. (21509165)
2011
20
Ambulatory high-dose methotrexate administration among pediatric osteosarcoma patients in an urban, underserved setting is feasible, safe, and cost-effective. (20949591)
2010
21
Staged lengthening arthroplasty for pediatric osteosarcoma around the knee. (19885713)
2010
22
Proteomic analysis of chemonaive pediatric osteosarcomas and corresponding normal bone reveals multiple altered molecular targets. (19492781)
2009
23
Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression. (19159907)
2009
24
Clinical characteristics and treatment results of pediatric osteosarcoma: the role of high dose chemotherapy with autologous stem cell transplantation. (19688126)
2008
25
Treatment results of pediatric osteosarcoma: twenty-year experience. (17314654)
2007
26
Exploratory analysis of Fas gene polymorphisms in pediatric osteosarcoma patients. (18090928)
2007
27
The cause and clinical significance of central tumor photopenia on thallium scintigraphy of pediatric osteosarcoma of the extremity. (17242270)
2007
28
Toxicity prevention with amifostine in pediatric osteosarcoma patients treated with cisplatin and doxorubicin. (17710657)
2007
29
Identification of a plasma proteomic signature to distinguish pediatric osteosarcoma from benign osteochondroma. (16673437)
2006
30
Tumor necrosis in pediatric osteosarcoma: impact of modern therapies. (16766682)
2006
31
An expression signature classifies chemotherapy-resistant pediatric osteosarcoma. (15753370)
2005
32
Pediatric osteosarcoma: a 35-year experience in Slovenia. (16020121)
2005
33
High-dose ifosfamide in relapsed pediatric osteosarcoma: therapeutic effects and renal toxicity. (15503294)
2005
34
Frequent genomic abnormalities at TWIST in human pediatric osteosarcomas. (15900593)
2005
35
Improved survival in primary nonmetastatic pediatric osteosarcoma of the extremity. (16131881)
2005
36
Biology and therapeutic advances for pediatric osteosarcoma. (15266096)
2004
37
Superior survival in treatment of primary nonmetastatic pediatric osteosarcoma of the extremity. (12794015)
2003
38
Genetic and epigenetic alterations of the cell cycle regulators and tumor suppressor genes in pediatric osteosarcomas. (12759621)
2003
39
Loss of p16(INK4a) expression correlates with decreased survival in pediatric osteosarcomas. (11241308)
2001
40
Dynamic magnetic resonance imaging of regional contrast access as an additional prognostic factor in pediatric osteosarcoma. (11413510)
2001
41
Circulating concentrations of IGF-I and IGFBP-3 are not predictive of incidence or clinical behavior of pediatric osteosarcoma. (11344491)
2001
42
Neoadjuvant chemotherapy for pediatric osteosarcoma patients. (9010116)
1997
43
NCCN pediatric osteosarcoma practice guidelines. The National Comprehensive Cancer Network. (8985965)
1996
44
Mutational activation of ras genes is absent in pediatric osteosarcoma. (7850751)
1995
45
Pediatric osteosarcoma - treatment of the primary tumor with intravenous cis-diamminedichloroplatinum-ii (cdp) - comparison of the results with the reported efficacy of intraarterial cdp. (21573359)
1993
46
Pediatric osteosarcoma: treatment of the primary tumor with intraarterial cis-diamminedichloroplatinum-II (CDP)--advantages, disadvantages, and controversial issues. (8096762)
1993
47
Development and characterization of pediatric osteosarcoma xenografts. (2328504)
1990
48
Pediatric osteosarcoma. Successful retreatment of relapsed primary tumor and soft tissue recurrence with intraarterial cis-diamminedichloroplatin-II. (2386906)
1990
49
Pediatric osteosarcoma: therapeutic strategies, results, and prognostic factors derived from a 10-year experience. (2230890)
1990
50
Auditory function in pediatric osteosarcoma patients treated with multiple doses of cis-diamminedichloroplatinum(II). (2910492)
1989

Variations for Pediatric Osteosarcoma

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Expression for genes affiliated with Pediatric Osteosarcoma

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Search GEO for disease gene expression data for Pediatric Osteosarcoma.

Pathways for genes affiliated with Pediatric Osteosarcoma

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Pathways related to Pediatric Osteosarcoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 55)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.1FOLR1, SLC19A1
2
Show member pathways
Glycine Metabolism36
glycine biosynthesis I36
folate transformations36
10.1SHMT1, MTR
39.9IGF1, IGFBP3
4
Show member pathways
L-serine degradation36
pentose phosphate pathway (oxidative branch)36
formaldehyde oxidation II (glutathione-dependent)36
9.8SHMT1, MTHFR, MTR
5
Show member pathways
9.6TP53, CDKN2A
69.6RB1, DHFR, TYMS
7
Show member pathways
FAS pathway and Stress induction of HSP regulation36
Apoptosis and survival FAS signaling cascades59
Caspase cascade in apoptosis36
9.5RB1, FAS, IGF1
8
Show member pathways
9.4CCND1, TP53, IGF1
9
Show member pathways
Signal transduction PTEN pathway59
9.4CCND1, TP53, IGF1
10
Show member pathways
flavin biosynthesis IV (mammalian)36
molybdenum cofactor biosynthesis36
coenzyme A biosynthesis36
thiamin salvage III36
alanine biosynthesis III36
thio-molybdenum cofactor biosynthesis36
biotin-carboxyl carrier protein assembly36
9.3SHMT1, DHFR, MTHFR, MTR, SLC19A1
11
Show member pathways
One Carbon Metabolism36
dTMP de novo biosynthesis (mitochondrial)36
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate36
Trans-sulfuration and one carbon metabolism36
methionine salvage36
Methionine metabolism59
9.3DHFR, MTR, MTHFR, SHMT1, TYMS
129.3RB1, FAS, TWIST1, IGF1
139.3CCND1, RB1, TP53
14
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
9.3CCND1, RB1, TP53
159.3TP53, CCND1, RB1
16
Show member pathways
9.3TYMS, DHFR, MTHFR, TP53
179.2TP53, CDKN2A, RB1
189.2CDKN2A, RB1, TP53
19
Show member pathways
Translation Non genomic rapid action of Androgen Receptor59
9.2IGF1, EZR, CCND1
209.2MIR210, CCND1, TP53
21
Show member pathways
Integrin-mediated cell adhesion36
Focal Adhesion36
9.1IGF1, CCND1, PDGFRA, RB1
229.1CCND1, TP53, IGF1, PDGFRA
239.1DHFR, PDGFRA, SLC19A1, MTR, MTHFR, SHMT1
24
Show member pathways
Development IGF RI signaling
Immune response IL 4 signaling pathway59
Signal transduction AKT signaling59
9.1TP53, IGF1, IGFBP3, CCND1
25
Show member pathways
TRAIL signaling pathway36
9.1EZR, RFC1, FAS
269.1RB1, TP53, IGFBP3, FAS
27
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
9.1TP53, CDKN2A, IGF1, FAS
28
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.0RB1, TP53, FAS, CCND1
29
Show member pathways
9.0CCND1, RB1, FAS, TP53
308.9RB1, CCND1, TP53, CDKN2A
31
Show member pathways
Cell cycle36
8.9RB1, CDKN2A, CCND1, TP53
32
Show member pathways
8.9TP53, CCND1, RB1, CDKN2A
33
Show member pathways
8.9CDKN2A, CCND1, TP53, RB1
348.8TYMS, DHFR, RB1, CCND1, TP53
35
Show member pathways
8.7IGF1, CDKN2A, RB1, PDGFRA, TP53
36
Show member pathways
8.6CCND1, RB1, TYMS, TP53, CDKN2A
378.6CDKN2A, RB1, TP53, CCND1, PDGFRA
388.6CDKN2A, IGFBP3, IGF1, TP53, RB1
39
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I59
8.5RB1, RFC1, TP53, FAS, CCND1
40
Show member pathways
8.4TP53, TYMS, CDKN2A, CCND1, RB1, DHFR
41
Show member pathways
8.3RB1, IGF1, TP53, CCND1, PDGFRA, CDKN2A
42
Show member pathways
Signaling Pathways in Glioblastoma36
8.3TP53, CDKN2A, RB1, PDGFRA, CCND1, IGF1
438.3TP53, RB1, IGF1, CCND1, PDGFRA, CDKN2A
44
Show member pathways
8.3IGF1, RB1, TP53, CDKN2A, PDGFRA, CCND1
458.3FAS, IGF1, PDGFRA, CCND1, TYMS, TP53
468.3CCND1, FAS, TWIST1, TP53, EZR, IGF1
478.0IGF1, CDKN2A, TP53, RB1, PDGFRA, CCND1
48
Show member pathways
7.9CCND1, CDKN2A, RFC1, TP53, RB1, TYMS
49
Show member pathways
DNA damage response36
7.5RFC1, RB1, CCND1, FAS, CDKN2A, TP53
507.1TP53, MIR214, MIR210, CCND1, EZR, CDKN2A

Compounds for genes affiliated with Pediatric Osteosarcoma

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Compounds related to Pediatric Osteosarcoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 199)
idCompoundScoreTop Affiliating Genes
1ag 3314410.1SLC19A1, TYMS, DHFR
2metoprine4410.0SLC19A1, DHFR, TYMS
3ag 3374410.0SLC19A1, TYMS, DHFR
4pt5234410.0SLC19A1, DHFR, TYMS
55-methyltetrahydrofolate44 1110.9FOLR1, SLC19A1, MTR, MTHFR
6b vitamins449.9TYMS, SHMT1, MTHFR, MTR
710-formyltetrahydrofolate449.9SLC19A1, MTR, DHFR, MTHFR
8Tetrahydrofolic acid24 1110.8SHMT1, MTR, DHFR, MTHFR
9ag 2034449.8DHFR, SLC19A1, TYMS
10folic acid50 24 1111.7MTHFR, SLC19A1, DHFR, FOLR1
11trimetrexate44 1110.7TYMS, DHFR, FOLR1, SLC19A1, CDKN2A
12tomudex449.6SLC19A1, FOLR1, TP53, TYMS, DHFR
13leucovorin44 50 1111.5FOLR1, MTHFR, SLC19A1, DHFR, TYMS, SHMT1
14tetrahydrofolate449.5MTHFR, TYMS, SLC19A1, MTR, DHFR, SHMT1
15vitamin b12449.4IGF1, MTR, MTHFR, TYMS, IGFBP3
16fluorouracil50 1110.2MTHFR, SHMT1, TP53, SLC19A1, TYMS, CCND1
17purine44 2410.1SLC19A1, DHFR, SHMT1, CDKN2A, TYMS, MTHFR
18valine449.1DHFR, MTR, IGFBP3, CDKN2A, MTHFR, TYMS
19irinotecan44 50 1111.1MTHFR, SLC19A1, TYMS, SHMT1, CDKN2A, TP53
20olomoucine44 1110.0RB1, CDKN2A, TP53, CCND1
215-aza-2deoxycytidine449.0TP53, SLC19A1, IGFBP3, FAS, FOLR1, CDKN2A
22n-(4-hydroxyphenyl)retinamide449.0CCND1, RB1, TP53, IGFBP3, IGF1
23depsipeptide449.0RB1, TP53, FAS, CCND1, CDKN2A
24carboplatin44 50 1110.9MTHFR, TP53, RB1, SLC19A1, TYMS
25mitomycin c448.9TYMS, FAS, DHFR, RB1, TP53
26cytarabine44 50 1110.9RB1, TYMS, CDKN2A, DHFR, FAS, TP53
27vincristine44 50 1110.8MTR, CDKN2A, SLC19A1, CCND1, TP53, RB1
28hydroxyurea44 50 1110.8TYMS, TP53, DHFR, PDGFRA, CDKN2A
29egcg448.7TP53, IGFBP3, CCND1, RB1, CDKN2A, FAS
30etoposide44 50 60 1111.7TP53, FAS, DHFR, TYMS, IGFBP3, IGF1
31gemcitabine44 50 1110.6CCND1, DHFR, MTHFR, TP53, TYMS
32dihydrofolate448.6DHFR, SHMT1, TYMS, SLC19A1, FOLR1, MTR
33butyrate448.3TYMS, TP53, FAS, DHFR, IGFBP3, CDKN2A
34adriamycin448.3IGF1, TP53, FAS, DHFR, TYMS, CDKN2A
35cysteine448.2TYMS, RB1, IGFBP3, FAS, DHFR, MTHFR
365fluorouracil448.1CDKN2A, SLC19A1, MTHFR, DHFR, TP53, RB1
37ly294002448.1IGF1, TP53, IGFBP3, EZR, FAS, CCND1
38folate448.1CDKN2A, TYMS, IGFBP3, DHFR, FOLR1, CCND1
39paraffin448.0RB1, TP53, CDKN2A, EZR, PDGFRA, CCND1
40thymidine44 249.0RB1, CCND1, MTHFR, TP53, IGF1, TYMS
41arginine447.9FAS, TYMS, IGFBP3, IGF1, TP53, RFC1
42methotrexate50 44 119.9TYMS, IGFBP3, SHMT1, DHFR, FOLR1, CCND1
43vegf447.9RB1, IGFBP3, IGF1, TP53, FAS, CCND1
44paclitaxel44 50 119.7SLC19A1, CDKN2A, RB1, TWIST1, CCND1, FOLR1
45doxorubicin44 50 119.7TYMS, MTR, IGFBP3, TP53, FAS, DHFR
46retinoic acid44 248.6RB1, PDGFRA, CCND1, TP53, FAS, IGF1
47thymidylate447.5DHFR, SLC19A1, FOLR1, CCND1, MTHFR, MTR
48cisplatin44 50 60 1110.4TYMS, IGFBP3, TP53, SLC19A1, CDKN2A, RB1
49estrogen446.9TWIST1, EZR, IGFBP3, IGF1, TP53, DHFR
50serine446.3TP53, EZR, SHMT1, IGF1, IGFBP3, TYMS

GO Terms for genes affiliated with Pediatric Osteosarcoma

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Cellular components related to Pediatric Osteosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor binding protein complexGO:00169429.8IGFBP3, IGF1
2nucleoplasmGO:00056548.1TP53, RFC1, CCND1, RB1, CDKN2A, TYMS
3cytosolGO:00058297.4CDKN2A, TYMS, SHMT1, EZR, TP53, FAS
4nucleusGO:00056346.6TYMS, IGFBP3, SHMT1, TP53, RFC1, FAS

Biological processes related to Pediatric Osteosarcoma according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1folic acid transportGO:001588410.4FOLR1, SLC19A1
2tetrahydrofolate interconversionGO:003599910.3SHMT1, MTHFR
3response to folic acidGO:005159310.2TYMS, MTHFR
4positive regulation of insulin-like growth factor receptor signaling pathwayGO:004356810.1IGFBP3, IGF1
5Leydig cell differentiationGO:003332710.1PDGFRA, CCND1
6mitotic G1 DNA damage checkpointGO:003157110.0CCND1, TP53
7folic acid metabolic processGO:00466559.9MTHFR, SHMT1, FOLR1, SLC19A1
8replicative senescenceGO:00903999.9CDKN2A, TP53
9cell cycle checkpointGO:00000759.9CDKN2A, RB1
10myoblast differentiationGO:00454459.9RB1, IGF1
11water-soluble vitamin metabolic processGO:00067679.9MTR, MTHFR, SHMT1, SLC19A1
12vitamin metabolic processGO:00067669.9SHMT1, MTHFR, MTR, SLC19A1
13regulation of transcription involved in G1/S transition of mitotic cell cycleGO:00000839.8RB1, TYMS
14phosphatidylinositol-mediated signalingGO:00480159.7TYMS, IGF1, PDGFRA
15positive regulation of cell cycle arrestGO:00711589.5CDKN2A, TP53
16G1/S transition of mitotic cell cycleGO:00000829.4CDKN2A, RB1, CCND1, TYMS
17response to X-rayGO:00101659.4CCND1, TP53
18cell cycle arrestGO:00070509.3CDKN2A, RB1, TP53
19Ras protein signal transductionGO:00072659.3IGF1, TP53, RB1, CDKN2A
20negative regulation of cell proliferationGO:00082859.2IGFBP3, IGF1, CDKN2A, TP53
21positive regulation of transcription from RNA polymerase II promoterGO:00459448.9TWIST1, TP53, IGF1, CDKN2A, RB1
22mitotic cell cycleGO:00002788.9CDKN2A, TYMS, RFC1, CCND1, RB1
23positive regulation of transcription, DNA-templatedGO:00458938.7RFC1, TP53, IGF1, RB1, CDKN2A

Molecular functions related to Pediatric Osteosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1folic acid bindingGO:00055429.9SLC19A1, FOLR1, TYMS
2folic acid transporter activityGO:00085179.8FOLR1, SLC19A1
3MDM2/MDM4 family protein bindingGO:00973719.5CDKN2A, TP53
4transcription factor bindingGO:00081348.7TP53, CCND1, TWIST1, RB1, CDKN2A
5protein bindingGO:00055156.4IGF1, EZR, TP53, RFC1, FAS, CCND1

Sources for Pediatric Osteosarcoma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet