MCID: PDT035
MIFTS: 45

Pediatric Systemic Lupus Erythematosus malady

Neuronal diseases, Nephrological diseases, Respiratory diseases, Bone diseases, Rare diseases categories

Summaries for Pediatric Systemic Lupus Erythematosus

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MalaCards based summary: Pediatric Systemic Lupus Erythematosus, also known as sle, pediatric onset, is related to lupus erythematosus and systemic lupus erythematosus. An important gene associated with Pediatric Systemic Lupus Erythematosus is STAT4 (signal transducer and activator of transcription 4), and among its related pathways are 14-3-3 and Regulation of BAD Activity and EBV LMP1 signaling. The compounds tab-1 and mycophenolic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and lung, and related mouse phenotypes are renal/urinary system and adipose tissue.

Aliases & Classifications for Pediatric Systemic Lupus Erythematosus

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Sources:
47Orphanet, 26ICD10 via Orphanet
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Related Diseases for Pediatric Systemic Lupus Erythematosus

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Diseases related to Pediatric Systemic Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus32.3APOH, C3, C4A
2systemic lupus erythematosus32.2TNFSF13B, STAT4, C4A
3arthritis31.2TNF, TNFRSF1A
4calcinosis30.9SPP1
5antiphospholipid syndrome30.9VCAM1, APOH
6nephritis30.5TNFSF13B, APOH, VCAM1, C3, C4A
7atherosclerosis29.5SPP1, TNF, APOH, VCAM1, IRAK1, ICAM1
8retinal vasculitis10.5APOH
9retinal artery occlusion10.5APOH
10thrombocytopenia10.5
11complement deficiency10.4C3, C4A
12meningitis10.4
13neuritis10.4
14neuropathy10.4
15optic neuritis10.4
16peripheral neuropathy10.4
17purpura10.4
18coronary restenosis10.4SPP1
19leishmaniasis10.4TNFRSF1A
20severe pre-eclampsia10.4APOH, VCAM1
21leukostasis10.4VCAM1, ICAM1
22rheumatoid vasculitis10.4VCAM1, ICAM1
23periodic fever, familial10.4TNF, TNFRSF1A
24arteriosclerosis obliterans10.3VCAM1, ICAM1
25henoch-schoenlein purpura10.3ICAM1, VCAM1
26inclusion body myositis10.3ICAM1, VCAM1
27oral lichen planus10.3ICAM1, VCAM1
28common variable immunodeficiency10.3TNFSF13B, TNFRSF1A
29familial mediterranean fever, ar10.3TNF, TNFRSF1A
30vernal keratoconjunctivitis10.3VCAM1, ICAM1
31alcoholic hepatitis10.3TNF, ICAM1
32sjogren's syndrome10.3ICAM1, APOH, TNFSF13B
33ameloblastoma10.2TNFRSF1A, E2F1
34c1q deficiency10.2
35myocardial infarction10.2
36acute myocardial infarction10.2
37hemolytic anemia10.2
38neuromyelitis optica10.2
39myelitis10.2
40acute pancreatitis10.2
41epiglottitis10.2
42autoimmune hemolytic anemia10.2
43hemolytic-uremic syndrome10.2
44aseptic meningitis10.2
45acute myocarditis10.2
46myocarditis10.2
47myositis10.2
48pancreatitis10.2
49chronic lymphocytic leukemia10.2TNFSF13B, TNFRSF1A, ICAM1
50relapsing-remitting multiple sclerosis10.2SPP1, ICAM1

Graphical network of the top 20 diseases related to Pediatric Systemic Lupus Erythematosus:



Diseases related to pediatric systemic lupus erythematosus

Symptoms for Pediatric Systemic Lupus Erythematosus

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Drugs & Therapeutics for Pediatric Systemic Lupus Erythematosus

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Drug clinical trials:

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Search NIH Clinical Center for Pediatric Systemic Lupus Erythematosus

Genetic Tests for Pediatric Systemic Lupus Erythematosus

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Anatomical Context for Pediatric Systemic Lupus Erythematosus

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MalaCards organs/tissues related to Pediatric Systemic Lupus Erythematosus:

31
Bone, Spinal cord, Lung, B cells, Neutrophil

Animal Models for Pediatric Systemic Lupus Erythematosus or affiliated genes

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Publications for Pediatric Systemic Lupus Erythematosus

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Articles related to Pediatric Systemic Lupus Erythematosus:

(show top 50)    (show all 94)
idTitleAuthorsYear
1
Cytomegalovirus in pediatric systemic lupus erythematosus: prevalence and clinical manifestations. (25568145)
2015
2
National trends in pediatric systemic lupus erythematosus hospitalization in the United States: 2000-2009. (24488419)
2014
3
Comorbidities of pediatric systemic lupus erythematosus: A 6-year nationwide population-based study. (25066707)
2014
4
Blood gene expression profiling in pediatric systemic lupus erythematosus and systemic juvenile idiopathic arthritis: from bench to bedside. (24839407)
2014
5
Hypogammaglobulinemia in pediatric systemic lupus erythematosus. (24106215)
2013
6
Dual downregulation of microRNA 17-5p and E2F1 transcriptional factor in pediatric systemic lupus erythematosus patients. (23129428)
2013
7
Reversible splenial lesion syndrome in pediatric systemic lupus erythematosus. (22859530)
2012
8
Defective DNA double-strand break repair in pediatric systemic lupus erythematosus. (21905016)
2012
9
Bilateral optic neuritis in pediatric systemic lupus erythematosus with antiphospholipid antibody syndrome. (20882428)
2011
10
Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. (21389264)
2011
11
Measures of disease activity and damage in pediatric systemic lupus erythematosus: British Isles Lupus Assessment Group (BILAG), European Consensus Lupus Activity Measurement (ECLAM), Systemic Lupus Activity Measure (SLAM), Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), Physician's Global Assessment of Disease Activity (MD Global), and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SLICC/ACR DI; SDI). (22588739)
2011
12
Case series of pediatric systemic lupus erythematosus from Kerala: comparison with other Indian series. (21199476)
2010
13
A proposed framework to standardize the neurocognitive assessment of patients with pediatric systemic lupus erythematosus. (20589693)
2010
14
Prognostic impact of atypical presentation in pediatric systemic lupus erythematosus: results from a multicenter study. (20236656)
2010
15
Acute epiglottitis as the initial presentation of pediatric Systemic Lupus Erythematosus. (19878586)
2009
16
Premature atherosclerosis in pediatric systemic lupus erythematosus: risk factors for increased carotid intima-media thickness in the atherosclerosis prevention in pediatric lupus erythematosus cohort. (19404953)
2009
17
Acute pancreatitis as the initial presentation in pediatric systemic lupus erythematosus. (19475344)
2009
18
B-cell depletion for autoimmune thrombocytopenia and autoimmune hemolytic anemia in pediatric systemic lupus erythematosus. (19074962)
2009
19
Longitudinal myelitis, aseptic meningitis, and conus medullaris infarction as presenting manifestations of pediatric systemic lupus erythematosus. (18413416)
2008
20
MAGE-B2 autoantibody: a new biomarker for pediatric systemic lupus erythematosus. (19004030)
2008
21
Therapy Insight: cardiovascular disease in pediatric systemic lupus erythematosus. (18349862)
2008
22
Measuring permanent damage in pediatric systemic lupus erythematosus. (17711904)
2007
23
Flares in pediatric systemic lupus erythematosus. (17477466)
2007
24
Urine macrophage migration inhibitory factor in pediatric systemic lupus erythematosus. (17479310)
2007
25
Outcome of a national Israeli cohort of pediatric systemic lupus erythematosus. (17402372)
2007
26
Longitudinal examination of lipid profiles in pediatric systemic lupus erythematosus. (17265498)
2007
27
Pediatric systemic lupus erythematosus with C1q deficiency. (17893985)
2007
28
Neuropsychiatric involvement in pediatric systemic lupus erythematosus. (17711889)
2007
29
Antiphospholipid antibodies in pediatric systemic lupus erythematosus and the antiphospholipid syndrome. (17711899)
2007
30
Three distinct profiles of serum complement C4 proteins in pediatric systemic lupus erythematosus (SLE) patients: tight associations of complement C4 and C3 protein levels in SLE but not in healthy subjects. (16893076)
2006
31
Neuropsychiatric manifestations in pediatric systemic lupus erythematosus and association with antiphospholipid antibodies. (16845706)
2006
32
Pediatric systemic lupus erythematosus in Siriraj Hospital. (16858852)
2005
33
Hypovolemic shock as an initial presentation of pediatric systemic lupus erythematosus. (15910467)
2005
34
Update on pediatric systemic lupus erythematosus. (15314498)
2004
35
Peripheral neuropathy in pediatric systemic lupus erythematosus. (12770683)
2003
36
Peripheral neuropathy in pediatric systemic lupus erythematosus. (12160975)
2002
37
Tumor necrosis factor induced adhesion molecule serum concentrations in Henoch-SchAPnlein purpura and pediatric systemic lupus erythematosus. (10990243)
2000
38
Neurologic, ophthalmic, and neuropsychiatric manifestations of pediatric systemic lupus erythematosus. (10966064)
2000
39
Sex differences in pediatric systemic lupus erythematosus: a retrospective analysis of 135 cases. (10637715)
1999
40
Differences in tumor necrosis factor-alpha soluble receptor serum concentrations between patients with Henoch-SchAPnlein purpura and pediatric systemic lupus erythematosus: pathogenetic implications. (9489835)
1998
41
A case of pediatric systemic lupus erythematosus with early onset and unusual serologic and clinical findings. (9558773)
1997
42
Catastrophic antiphospholipid antibody syndrome in pediatric systemic lupus erythematosus. (9035002)
1997
43
Antiphospholipid antibodies in pediatric systemic lupus erythematosus. (7491218)
1995
44
Neurologic manifestations of pediatric systemic lupus erythematosus. (8554655)
1995
45
Anticardiolipin antibodies in pediatric systemic lupus erythematosus. (8148941)
1994
46
Pediatric systemic lupus erythematosus and neonatal lupus. (8153396)
1994
47
Acute myocardial infarction in pediatric systemic lupus erythematosus. (2380828)
1990
48
Neuropsychologic deficits and antineuronal antibodies in pediatric systemic lupus erythematosus. (2397630)
1990
49
Dyslipoproteinemia in pediatric systemic lupus erythematosus. (3134897)
1988
50
Perspectives in pediatric systemic lupus erythematosus. (3612646)
1987

Variations for Pediatric Systemic Lupus Erythematosus

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Expression for genes affiliated with Pediatric Systemic Lupus Erythematosus

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Search GEO for disease gene expression data for Pediatric Systemic Lupus Erythematosus.

Pathways for genes affiliated with Pediatric Systemic Lupus Erythematosus

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Pathways related to Pediatric Systemic Lupus Erythematosus according to GeneCards Suite gene sharing:

(show all 46)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1TNFRSF1A
29.6TNF, IRAK1
3
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
9.5C3, C4A, C4B
4
Show member pathways
Immune response Alternative complement pathway58
Immune response Lectin Induced complement pathway58
Immune response Classic complement pathway58
9.5C3, C4A, C4B
59.4TNFRSF1A, TNF
6
Show member pathways
9.4TNFRSF1A, TNF
7
Show member pathways
9.4TNFRSF1A, TNF
8
Show member pathways
9.4TNFRSF1A, TNF
99.4VCAM1, PTPN22, TNFSF13B
109.4TNF, VCAM1
119.3TNF, C4A, C4B
129.2SPP1, VCAM1, ICAM1
13
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
9.2IRAK1, TNFRSF1A, TNF
14
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.2IRAK1, TNFRSF1A, TNF
159.2TNF, TNFRSF1A, IRAK1
16
Show member pathways
9.2TNF, TNFRSF1A, IRAK1
17
Show member pathways
RANKL/RANK Signaling Pathway36
Apoptosis and survival APRIL and BAFF signaling58
9.2ICAM1, VCAM1, TNFSF13B
189.1C3, ICAM1, VCAM1
19
Show member pathways
9.1TNFRSF1A, TNF, TNFSF13B
20
Show member pathways
9.0SPP1, VCAM1, ICAM1, STAT4
219.0C4B, C4A, C3, ICAM1
229.0TNFSF13B, TNF, ICAM1
238.9TNF, TNFRSF1A, E2F1
24
Show member pathways
8.9TNF, C3, C4A, C4B
258.9ICAM1, VCAM1, TNF
268.9ICAM1, VCAM1, TNF
278.9ICAM1, VCAM1, TNF
288.9ICAM1, VCAM1, TNF
29
Show member pathways
8.9TNFSF13B, TNF, TNFRSF1A, STAT4
30
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway58
8.9IRAK1, TNFRSF1A, TNF, TNFSF13B
31
Show member pathways
8.9TNFSF13B, TNF, TNFRSF1A, IRAK1
32
Show member pathways
8.9TNFSF13B, TNF, TNFRSF1A, IRAK1
33
Show member pathways
8.8PTPN22, TNFRSF1A, TNF, TNFSF13B
348.8TNF, TNFRSF1A, IRAK1, C3
358.7TNF, IRAK1, C3, C4A, C4B
36
Show member pathways
8.6TNFSF13B, TNF, TNFRSF1A, IRAK1, STAT4
37
Show member pathways
8.6TNF, TNFRSF1A, IRAK1, STAT4, C3
388.5ICAM1, VCAM1, TNFRSF1A, TNF
398.5TNFSF13B, TNF, E2F1, ICAM1
40
Show member pathways
8.3TNF, TNFRSF1A, IRAK1, ICAM1, C3
41
Show member pathways
8.3TNFSF13B, TNF, TNFRSF1A, ICAM1, C4A
42
Show member pathways
8.2SPP1, TNF, TNFRSF1A, E2F1, IRAK1, STAT4
437.9TNF, TNFRSF1A, E2F1, VCAM1, ICAM1
447.9ICAM1, IRAK1, VCAM1, TNFRSF1A, TNF, TNFSF13B
45
Show member pathways
7.8SPP1, TNFSF13B, TNF, TNFRSF1A, E2F1, IRAK1
46
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
7.8SPP1, TNF, TNFRSF1A, E2F1, IRAK1, STAT4

Compounds for genes affiliated with Pediatric Systemic Lupus Erythematosus

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Compounds related to Pediatric Systemic Lupus Erythematosus according to GeneCards Suite gene sharing:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1tab-1439.6IRAK1, TNFRSF1A, TNF
2mycophenolic acid43 49 1211.6VCAM1, SPP1, ICAM1
3txb2439.5APOH, IRAK1, C4A
4agarose439.5APOH, C4B, C4A, C3
5bcma439.5TNFSF13B, TNFRSF1A, TNF
6blys439.5TNFRSF1A, TNF, TNFSF13B
7lipoteichoic acid439.5APOH, TNF, IRAK1
8cuprophan439.4TNFRSF1A, VCAM1, ICAM1
9infliximab43 49 1211.3APOH, TNFRSF1A, TNF, SPP1
10apocynin43 5910.2VCAM1, TNF, ICAM1
11polymyxin b439.2VCAM1, TNF, ICAM1
12groalpha439.1VCAM1, TNF, ICAM1
13budesonide43 49 1211.1TNF, VCAM1, ICAM1
14etanercept43 49 1211.1APOH, TNFRSF1A, TNF
15parthenolide43 210.1ICAM1, VCAM1, TNF
168-isoprostane439.0APOH, VCAM1, ICAM1, TNF
17troglitazone43 28 59 1212.0ICAM1, SPP1, TNF, VCAM1
18neopterin438.9TNF, C3, TNFRSF1A, ICAM1
19creatinine438.9C3, APOH, TNFRSF1A, TNFSF13B, SPP1
20okt3438.9TNFRSF1A, VCAM1, ICAM1, TNF
21sp 60012543 599.8TNF, ICAM1, VCAM1, TNFRSF1A
22simvastatin43 49 59 28 24 1213.8TNFRSF1A, TNF, ICAM1, VCAM1
23heparin43 28 24 1211.7C4B, C3, VCAM1, TNFRSF1A, SPP1, APOH
24genistein43 28 59 2 24 1213.7SPP1, VCAM1, ICAM1, IRAK1, TNF
25fmlp438.7TNFRSF1A, ICAM1, TNF, VCAM1
26tgf beta1438.6TNFRSF1A, SPP1, VCAM1, E2F1, TNF
27herbimycin a43 599.6VCAM1, TNFRSF1A, TNF, SPP1, ICAM1
28curcumin438.6TNF, VCAM1, TNFRSF1A, SPP1, ICAM1
29superoxide43 249.6APOH, TNFRSF1A, VCAM1, TNF, SPP1
30rantes438.6VCAM1, TNFRSF1A, TNF, IRAK1, ICAM1
31methotrexate49 43 1210.6APOH, TNFRSF1A, TNF, E2F1
32sb 20358043 599.6VCAM1, ICAM1, TNFRSF1A, TNF, SPP1
33prostacyclin438.6ICAM1, TNF, TNFRSF1A, APOH, VCAM1
34alanine438.5IRAK1, VCAM1, TNFRSF1A, TNFSF13B, SPP1, E2F1
35actinomycin d438.5TNFRSF1A, E2F1, TNF, SPP1, ICAM1
36pge2438.5VCAM1, TNFRSF1A, SPP1, ICAM1, TNF
37fibrinogen438.4APOH, C3, ICAM1, VCAM1, SPP1, TNF
38lactate438.3SPP1, TNF, APOH, VCAM1, ICAM1, C3
39estrogen438.2TNFRSF1A, SPP1, C3, VCAM1, E2F1, APOH
40endotoxin438.1C4A, VCAM1, APOH, ICAM1, TNFRSF1A, TNF
41dexamethasone43 49 28 1211.0VCAM1, TNF, SPP1, STAT4, C3, ICAM1
42tyrosine437.9STAT4, IRAK1, SPP1, TNFRSF1A, E2F1, VCAM1
43cycloheximide437.8TNF, SPP1, TNFRSF1A, ICAM1, E2F1
44nitric oxide43 24 129.8TNFRSF1A, TNF, APOH, E2F1, VCAM1, ICAM1
45vegf437.8APOH, ICAM1, VCAM1, TNFRSF1A, TNF, SPP1
46retinoic acid43 248.7E2F1, TNFRSF1A, SPP1, VCAM1, TNF, ICAM1
47lipid437.7TNFRSF1A, TNF, SPP1, E2F1, APOH, VCAM1
48phosphatidylinositol437.6IRAK1, ICAM1, E2F1, STAT4, C3, APOH
49serine437.2TNF, C4B, C3, STAT4, IRAK1, VCAM1
50oxygen43 247.9TNF, TNFRSF1A, SPP1, APOH, C4A, E2F1

GO Terms for genes affiliated with Pediatric Systemic Lupus Erythematosus

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Cellular components related to Pediatric Systemic Lupus Erythematosus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725629.2C4B, C4A, C3
2external side of plasma membraneGO:00098978.9ICAM1, VCAM1, TNF
3cell surfaceGO:00099868.6TNF, TNFRSF1A, APOH, VCAM1
4extracellular regionGO:00055768.2SPP1, TNF, TNFRSF1A, C3, C4A, C4B
5extracellular spaceGO:00056157.3C3, SPP1, TNFSF13B, TNF, TNFRSF1A, APOH
6plasma membraneGO:00058867.0TNFSF13B, TNF, TNFRSF1A, VCAM1, IRAK1, ICAM1

Biological processes related to Pediatric Systemic Lupus Erythematosus according to GeneCards Suite gene sharing:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1regulation of complement activationGO:00304499.9C4B, C4A, C3
2complement activationGO:00069569.9C3, C4A, C4B
3complement activation, classical pathwayGO:00069589.9C4B, C4A, C3
4membrane to membrane dockingGO:00226149.8ICAM1, VCAM1
5response to amino acidGO:00432009.7ICAM1, TNFRSF1A
6lipopolysaccharide-mediated signaling pathwayGO:00316639.7IRAK1, TNF
7leukocyte tethering or rollingGO:00509019.7TNF, VCAM1
8response to lipopolysaccharideGO:00324969.6IRAK1, VCAM1, TNFRSF1A
9negative regulation of interleukin-6 productionGO:00327159.6TNF, TNFRSF1A
10leukocyte cell-cell adhesionGO:00071599.6ICAM1, VCAM1
11cellular response to glucose stimulusGO:00713339.5ICAM1, VCAM1
12cellular response to hypoxiaGO:00714569.5ICAM1, IRAK1, E2F1
13positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.4IRAK1, TNFRSF1A, TNF
14regulation of immune responseGO:00507769.4C3, ICAM1, VCAM1
15heterophilic cell-cell adhesionGO:00071579.4ICAM1, VCAM1
16response to ethanolGO:00454719.4TNFRSF1A, VCAM1, ICAM1
17positive regulation of nitric oxide biosynthetic processGO:00454299.3TNF, ICAM1
18positive regulation of NF-kappaB transcription factor activityGO:00510929.3TNF, IRAK1, ICAM1
19intrinsic apoptotic signaling pathway in response to DNA damageGO:00086309.3E2F1, TNFRSF1A, TNF
20cytokine-mediated signaling pathwayGO:00192219.2TNFRSF1A, VCAM1, ICAM1, STAT4
21response to hypoxiaGO:00016669.2VCAM1, TNFRSF1A, TNF
22innate immune responseGO:00450879.0C4B, C4A, C3, IRAK1
23extracellular matrix organizationGO:00301988.9SPP1, TNF, VCAM1, ICAM1
24positive regulation of transcription from RNA polymerase II promoterGO:00459448.8TNF, TNFRSF1A, E2F1, IRAK1, STAT4
25inflammatory responseGO:00069548.6C4B, SPP1, TNF, TNFRSF1A, C3, C4A

Molecular functions related to Pediatric Systemic Lupus Erythematosus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:00048669.5C4B, C4A, C3
2tumor necrosis factor receptor bindingGO:00051649.2TNFSF13B, TNF
3cytokine activityGO:00051259.1TNF, TNFSF13B, SPP1
4protein bindingGO:00055156.9TNF, TNFRSF1A, PTPN22, APOH, E2F1, IRAK1

Products for genes affiliated with Pediatric Systemic Lupus Erythematosus

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Sources for Pediatric Systemic Lupus Erythematosus

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3CDC
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25ICD10
26ICD10 via Orphanet
27ICD9CM
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29KEGG
33MeSH
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38NCIt
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