MCID: PDT035
MIFTS: 40

Pediatric Systemic Lupus Erythematosus malady

Categories: Neuronal diseases, Nephrological diseases, Respiratory diseases, Bone diseases, Rare diseases

Aliases & Classifications for Pediatric Systemic Lupus Erythematosus

Summaries for Pediatric Systemic Lupus Erythematosus

MalaCards based summary : Pediatric Systemic Lupus Erythematosus, also known as sle, pediatric onset, is related to systemic lupus erythematosus and lupus erythematosus. An important gene associated with Pediatric Systemic Lupus Erythematosus is STAT4 (Signal Transducer And Activator Of Transcription 4), and among its related pathways/superpathways are Innate Immune System and IL-2 Pathway. The drugs Vaccines and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include bone, b cells and neutrophil, and related phenotypes are Increased shRNA abundance (Z-score > 2) and hematopoietic system

Related Diseases for Pediatric Systemic Lupus Erythematosus

Diseases related to Pediatric Systemic Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
id Related Disease Score Top Affiliating Genes
1 systemic lupus erythematosus 10.7
2 lupus erythematosus 10.7
3 hemochromatosis 10.2 C3 C4A
4 gout susceptibility 4 10.2 C4A C4B
5 hypopharynx cancer 10.1 C4A C4B
6 frontal encephalocele 10.1 C4A C4B
7 macular degeneration, age-related, 13 10.1 C3 C4B
8 herpetic whitlow 10.1 C3 MX1
9 non-amyloid monoclonal immunoglobulin deposition disease 10.1 PTPN22 STAT4
10 malignant acth producing neoplasm of pituitary gland 10.0 C3 C4A
11 t-cell prolymphocytic leukemia 10.0 PTPN22 STAT4
12 cyclotropia 10.0 C3 C4A
13 dermatomycosis 10.0 C3 C4A C4B
14 polyomavirus allograft nephropathy 10.0 PTPN22 STAT4
15 purpura 9.9
16 arthritis 9.9
17 thrombocytopenia 9.9
18 articulation disorder 9.9 PTPN22 STAT4 TNFSF13B
19 pancreatitis 9.8
20 atherosclerosis 9.8
21 neuropathy 9.8
22 optic neuritis 9.8
23 meningitis 9.8
24 neuritis 9.8
25 acute pancreatitis 9.8
26 antiphospholipid syndrome 9.8
27 advanced sleep phase syndrome, familial, 1 9.7 MX1 SPP1 TNFSF13B
28 acute myocardial infarction 9.7
29 acute myocarditis 9.7
30 myositis 9.7
31 hemolytic anemia 9.7
32 autoimmune hemolytic anemia 9.7
33 neuromyelitis optica 9.7
34 myocarditis 9.7
35 cryptococcal meningitis 9.7
36 epiglottitis 9.7
37 aseptic meningitis 9.7
38 hemolytic-uremic syndrome 9.7
39 calcinosis 9.7
40 c1q deficiency 9.7
41 myocardial infarction 9.7
42 myelitis 9.7
43 chorioretinitis 9.6 C3 C4A C4B PTPN22 STAT4
44 cousin syndrome 9.1 C3 C4A C4B MX1 PTPN22 SPP1
45 x-linked dominant intellectual disability-epilepsy syndrome 8.4 C3 C4A C4B E2F1 IRAK1 MIR17

Graphical network of the top 20 diseases related to Pediatric Systemic Lupus Erythematosus:



Diseases related to Pediatric Systemic Lupus Erythematosus

Symptoms & Phenotypes for Pediatric Systemic Lupus Erythematosus

GenomeRNAi Phenotypes related to Pediatric Systemic Lupus Erythematosus according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.98 E2F1 TNFSF13B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.98 E2F1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.98 C4B C4A E2F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.98 C4B C4A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.98 E2F1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.98 E2F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.98 E2F1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.98 C4B C4A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.98 TNFSF13B
10 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.98 C4B C4A TNFSF13B
11 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.98 C4B C4A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.98 TNFSF13B
13 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.98 E2F1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.98 TNFSF13B
15 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.98 TNFSF13B
16 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.98 C4B C4A
17 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.98 C4B C4A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.98 C4B C4A TNFSF13B

MGI Mouse Phenotypes related to Pediatric Systemic Lupus Erythematosus:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.81 SPP1 STAT4 TNFSF13B C3 C4B E2F1
2 cardiovascular system MP:0005385 9.8 SPP1 C3 C4B E2F1 IRAK1 MYC
3 immune system MP:0005387 9.61 SPP1 STAT4 TNFSF13B C3 C4B E2F1
4 liver/biliary system MP:0005370 9.02 SPP1 C3 C4B MYC PTPN22

Drugs & Therapeutics for Pediatric Systemic Lupus Erythematosus

Drugs for Pediatric Systemic Lupus Erythematosus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4
2
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
3
Alendronate Approved Phase 2, Phase 3 121268-17-5, 66376-36-1 2088
4
Hydroxychloroquine Approved Phase 3 118-42-3 3652
5
leucovorin Approved, Nutraceutical Phase 3 58-05-9 54575, 6560146 143
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
7 Atorvastatin Calcium Phase 3 134523-03-8
8 glucocorticoids Phase 2, Phase 3,Phase 1
9 Vitamin B Complex Phase 3
10 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
11 Hypolipidemic Agents Phase 3
12 Anti-Infective Agents Phase 3
13 Anticholesteremic Agents Phase 3
14 Antimalarials Phase 3
15 Lipid Regulating Agents Phase 3
16 Antimetabolites Phase 3
17 Antirheumatic Agents Phase 3
18 Bone Density Conservation Agents Phase 2, Phase 3,Phase 1
19 Calcium, Dietary Phase 3
20 Antiparasitic Agents Phase 3
21 Antiprotozoal Agents Phase 3
22 Folate Nutraceutical Phase 3
23 Vitamin B9 Nutraceutical Phase 3
24
belimumab Approved Phase 2 356547-88-1 5957 10451420
25
Denosumab Approved Phase 1, Phase 2 615258-40-7
26
Cholecalciferol Approved, Nutraceutical Phase 2 67-97-0 6221 10883523 5280795
27
Ergocalciferol Approved, Nutraceutical Phase 2 50-14-6 5280793
28 Immunoglobulins Phase 2
29 Immunosuppressive Agents Phase 2
30 Antibodies Phase 2
31 Hormone Antagonists Phase 1, Phase 2
32 Hormones Phase 1, Phase 2
33 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
34 vitamin d Phase 2
35 Trace Elements Phase 2
36 Ergocalciferols Phase 2
37 Vitamins Phase 2
38 Interferon-alpha Phase 2
39 Micronutrients Phase 2
40 arginine Nutraceutical Phase 2
41 Vitamin D2 Nutraceutical Phase 2
42 Calciferol Nutraceutical Phase 2
43
Creatine Approved, Nutraceutical 57-00-1 586

Interventional clinical trials:

(show all 14)
id Name Status NCT ID Phase
1 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
2 Alendronate Osteoporosis Study Completed NCT00277251 Phase 2, Phase 3
3 Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) Completed NCT00065806 Phase 3
4 A Long-Term Study of the Safety and Tolerability of Repeated Administration of CEP-33457 in Patients With Systemic Lupus Erythematosus Terminated NCT01240694 Phase 3
5 L-arginine Therapy on Endothelium-dependent Vasodilation & Mitochondrial Metabolism in MELAS Syndrome Completed NCT01603446 Phase 2
6 Pediatric Lupus Trial of Belimumab Plus Background Standard Therapy Recruiting NCT01649765 Phase 2
7 Denosumab for Glucocorticoid-treated Children With Rheumatic Disorders Not yet recruiting NCT02418273 Phase 1, Phase 2
8 Vitamin D3 Treatment in Pediatric Systemic Lupus Erythematosus Terminated NCT01709474 Phase 2
9 Creatine Supplementation in Pediatric Rheumatology Unknown status NCT01217320
10 Health-related Quality of Life Measure in Pediatric Lupus Completed NCT00280137
11 GENetic & Immunologic Abnomalies in Systemic Lupus Erythematosus Completed NCT01992666
12 The CARRA Registry Completed NCT01697254
13 Study of Families With Twins or Siblings Discordant for Rheumatic Disorders Recruiting NCT00055055
14 Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence Study Active, not recruiting NCT01663129

Search NIH Clinical Center for Pediatric Systemic Lupus Erythematosus

Genetic Tests for Pediatric Systemic Lupus Erythematosus

Anatomical Context for Pediatric Systemic Lupus Erythematosus

MalaCards organs/tissues related to Pediatric Systemic Lupus Erythematosus:

39
Bone, B Cells, Neutrophil, Lung, Spinal Cord

Publications for Pediatric Systemic Lupus Erythematosus

Articles related to Pediatric Systemic Lupus Erythematosus:

(show top 50) (show all 107)
id Title Authors Year
1
Unraveling the expression of microRNA-27a* & NKG2D in peripheral blood mononuclear cells and natural killer cells of pediatric systemic lupus erythematosus patients. ( 28523761 )
2017
2
An Update on Treatment and Management of Pediatric Systemic Lupus Erythematosus. ( 27747587 )
2016
3
Idiopathic Thrombocytopenic Purpura Masquerading Pediatric Systemic Lupus Erythematosus. ( 27057049 )
2016
4
Acute pancreatitis as a cause of mortality in pediatric systemic lupus erythematosus: Results of a multiple cause-of-death analysis in France. ( 27079760 )
2016
5
Severe disease presentation and poor outcomes among pediatric systemic lupus erythematosus patients in South Africa. ( 27488473 )
2016
6
Lenalidomide for refractory cutaneous manifestations of pediatric systemic lupus erythematosus. ( 27837194 )
2016
7
Targeted B cell therapies in the treatment of adult and pediatric systemic lupus erythematosus. ( 27497253 )
2016
8
Alcohol, smoking and illicit drug use in pediatric systemic lupus erythematosus patients. ( 26949149 )
2016
9
Alcohol, smoking and illicit drug use in pediatric systemic lupus erythematosus patients. ( 27267641 )
2016
10
Autoantigen microarrays reveal autoantibodies associated with proliferative nephritis and active disease in pediatric systemic lupus erythematosus. ( 26081107 )
2015
11
Cytomegalovirus in pediatric systemic lupus erythematosus: prevalence and clinical manifestations. ( 25568145 )
2015
12
Increased activation of toll-like receptors-7 and -8 of peripheral blood mononuclear cells and upregulated serum cytokines in patients with pediatric systemic lupus erythematosus. ( 26884963 )
2015
13
Pediatric systemic lupus erythematosus presenting with coronary arteritis: A case series and review of the literature. ( 25840624 )
2015
14
Avascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature. ( 25902709 )
2015
15
High titer anti-basement membrane antibodies in a subset of patients with pediatric systemic lupus erythematosus. ( 25926050 )
2015
16
Pediatric systemic lupus erythematosus in a single nephrology unit. ( 25758881 )
2015
17
Targeting E2F1 and c-Myc expression by microRNA-17-5p represses interferon-stimulated gene MxA in peripheral blood mononuclear cells of pediatric systemic lupus erythematosus patients. ( 26175399 )
2015
18
Shrinking lung syndrome complicating pediatric systemic lupus erythematosus. ( 24756252 )
2014
19
Blood gene expression profiling in pediatric systemic lupus erythematosus and systemic juvenile idiopathic arthritis: from bench to bedside. ( 24839407 )
2014
20
Comorbidities of pediatric systemic lupus erythematosus: A 6-year nationwide population-based study. ( 25066707 )
2014
21
National trends in pediatric systemic lupus erythematosus hospitalization in the United States: 2000-2009. ( 24488419 )
2014
22
Safety and efficacy of rituximab in refractory pediatric systemic lupus erythematosus nephritis: a single-center experience of Northern Greece. ( 22101555 )
2013
23
Dual downregulation of microRNA 17-5p and E2F1 transcriptional factor in pediatric systemic lupus erythematosus patients. ( 23129428 )
2013
24
Cyclophosphamide exposure in pediatric systemic lupus erythematosus is associated with reduced serum anti-mullerian hormone levels. ( 23728191 )
2013
25
Acute myocarditis and ventricular fibrillation as initial presentation of pediatric systemic lupus erythematosus. ( 22119942 )
2013
26
Hypogammaglobulinemia in pediatric systemic lupus erythematosus. ( 24106215 )
2013
27
Dyslipidemia in pediatric systemic lupus erythematosus: the relationship with disease activity and plasma homocysteine and cysteine concentrations. ( 23942034 )
2013
28
Patterns and influence of familial autoimmunity in pediatric systemic lupus erythematosus. ( 22891746 )
2012
29
Hematological features of pediatric systemic lupus erythematosus: suggesting management strategies in children. ( 22495873 )
2012
30
Defective DNA double-strand break repair in pediatric systemic lupus erythematosus. ( 21905016 )
2012
31
Reversible splenial lesion syndrome in pediatric systemic lupus erythematosus. ( 22859530 )
2012
32
Pediatric systemic lupus erythematosus: more than a positive antinuclear antibody. ( 22301032 )
2012
33
The complement system in pediatric systemic lupus erythematosus, atypical hemolytic uremic syndrome, and complocentric membranoglomerulopathies. ( 22810363 )
2012
34
Measures of health-related quality of life in pediatric systemic lupus erythematosus: Childhood Health Assessment Questionnaire (C-HAQ), Child Health Questionnaire (CHQ), Pediatric Quality of Life Inventory Generic Core Module (PedsQL-GC), Pediatric Quality of Life Inventory Rheumatology Module (PedsQL-RM), and Simple Measure of Impact of Lupus Erythematosus in Youngsters (SMILEY). ( 22588765 )
2011
35
Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. ( 21389264 )
2011
36
Measures of disease activity and damage in pediatric systemic lupus erythematosus: British Isles Lupus Assessment Group (BILAG), European Consensus Lupus Activity Measurement (ECLAM), Systemic Lupus Activity Measure (SLAM), Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), Physician's Global Assessment of Disease Activity (MD Global), and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SLICC/ACR DI; SDI). ( 22588739 )
2011
37
High prevalence of myositis in a southeastern United States pediatric systemic lupus erythematosus cohort. ( 21827646 )
2011
38
Bilateral optic neuritis in pediatric systemic lupus erythematosus with antiphospholipid antibody syndrome. ( 20882428 )
2011
39
C1q and anti-C1q antibody levels are correlated with disease severity in Chinese pediatric systemic lupus erythematosus. ( 20033414 )
2011
40
Case series of pediatric systemic lupus erythematosus from Kerala: comparison with other Indian series. ( 21199476 )
2010
41
A proposed framework to standardize the neurocognitive assessment of patients with pediatric systemic lupus erythematosus. ( 20589693 )
2010
42
Bilateral optic neuritis in pediatric systemic lupus erythematosus associated with antiphospholipid antibodies and neuromyelitis optica immunoglobulin. ( 21214161 )
2010
43
Pediatric systemic lupus erythematosus in Thammasat University Hospital. ( 21294427 )
2010
44
Prognostic impact of atypical presentation in pediatric systemic lupus erythematosus: results from a multicenter study. ( 20236656 )
2010
45
Calcinosis cutis universalis with pediatric systemic lupus erythematosus. ( 20130918 )
2010
46
Ethnic differences in pediatric systemic lupus erythematosus. ( 19833755 )
2009
47
B lymphocyte stimulator expression in pediatric systemic lupus erythematosus and juvenile idiopathic arthritis patients. ( 19877053 )
2009
48
Premature atherosclerosis in pediatric systemic lupus erythematosus: risk factors for increased carotid intima-media thickness in the atherosclerosis prevention in pediatric lupus erythematosus cohort. ( 19404953 )
2009
49
B-cell depletion for autoimmune thrombocytopenia and autoimmune hemolytic anemia in pediatric systemic lupus erythematosus. ( 19074962 )
2009
50
Hypovitaminosis D is associated with greater body mass index and disease activity in pediatric systemic lupus erythematosus. ( 19446841 )
2009

Variations for Pediatric Systemic Lupus Erythematosus

Expression for Pediatric Systemic Lupus Erythematosus

Search GEO for disease gene expression data for Pediatric Systemic Lupus Erythematosus.

Pathways for Pediatric Systemic Lupus Erythematosus

Pathways related to Pediatric Systemic Lupus Erythematosus according to GeneCards Suite gene sharing:

(show all 13)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.71 C3 C4A C4B IRAK1 MX1 MYC
2
Show member pathways
12.88 E2F1 IRAK1 MYC SPP1 STAT4
3
Show member pathways
12.21 C3 E2F1 IRAK1 MYC SPP1 STAT4
4
Show member pathways
12.06 E2F1 MIR17 MYC
5 12.05 IRAK1 PTPN22 STAT4 TNFSF13B
6
Show member pathways
11.79 C3 C4A C4B
7 11.75 C3 C4A C4B
8
Show member pathways
11.71 C3 C4A C4B
9 11.62 E2F1 MYC TNFSF13B
10
Show member pathways
11.52 C3 C4A C4B
11 11.08 C3 C4A C4B
12 10.82 E2F1 MYC
13 10.81 C3 C4A C4B IRAK1

GO Terms for Pediatric Systemic Lupus Erythematosus

Cellular components related to Pediatric Systemic Lupus Erythematosus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 8.8 C3 C4A C4B

Biological processes related to Pediatric Systemic Lupus Erythematosus according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.83 E2F1 IRAK1 MYC SPP1
2 inflammatory response GO:0006954 9.73 C3 C4A C4B SPP1
3 cellular protein metabolic process GO:0044267 9.69 C3 C4A SPP1
4 complement activation, classical pathway GO:0006958 9.65 C3 C4A C4B
5 negative regulation of endopeptidase activity GO:0010951 9.63 C3 C4A C4B
6 regulation of complement activation GO:0030449 9.58 C3 C4A C4B
7 innate immune response GO:0045087 9.55 C3 C4A C4B IRAK1 MX1
8 cellular response to hypoxia GO:0071456 9.54 E2F1 IRAK1 MYC
9 complement activation GO:0006956 9.5 C3 C4A C4B
10 lipopolysaccharide-mediated signaling pathway GO:0031663 9.49 IRAK1 PTPN22
11 cellular response to testosterone stimulus GO:0071394 9.26 MYC SPP1
12 immune system process GO:0002376 9.17 C3 C4A C4B IRAK1 MX1 PTPN22
13 positive regulation of apoptotic cell clearance GO:2000427 9.13 C3 C4A C4B

Molecular functions related to Pediatric Systemic Lupus Erythematosus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endopeptidase inhibitor activity GO:0004866 8.8 C3 C4A C4B

Sources for Pediatric Systemic Lupus Erythematosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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