MCID: PDT035
MIFTS: 41

Pediatric Systemic Lupus Erythematosus

Categories: Neuronal diseases, Nephrological diseases, Respiratory diseases, Bone diseases, Rare diseases

Aliases & Classifications for Pediatric Systemic Lupus Erythematosus

Summaries for Pediatric Systemic Lupus Erythematosus

MalaCards based summary : Pediatric Systemic Lupus Erythematosus, also known as sle, pediatric onset, is related to alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity and lupus erythematosus. An important gene associated with Pediatric Systemic Lupus Erythematosus is C1R (Complement C1r), and among its related pathways/superpathways are Innate Immune System and Kaposi's sarcoma-associated herpesvirus infection. The drugs Vitamin D and Cholecalciferol have been mentioned in the context of this disorder. Affiliated tissues include bone, b cells and neutrophil, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Pediatric Systemic Lupus Erythematosus

Diseases related to Pediatric Systemic Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 29.6 PTPN22 TNFSF13B
2 lupus erythematosus 29.5 C1R C3 C4A C4B PTPN22 STAT4
3 systemic lupus erythematosus 27.8 C1R C3 C4A C4B MX1 PTPN22
4 lichen nitidus 10.3 C3 MX1
5 complement factor i deficiency 10.2 C3 C4B
6 hypersensitivity vasculitis 10.2 C3 C4A
7 juvenile dermatitis herpetiformis 10.2 C4A C4B
8 complement deficiency 10.1 C3 C4A
9 arthritis 10.0
10 thrombocytopenia 10.0
11 purpura 10.0
12 rheumatoid factor-negative juvenile idiopathic arthritis 10.0 PTPN22 STAT4
13 hypersensitivity reaction type iii disease 10.0 C3 C4A C4B
14 glomerulonephritis 9.9 C3 C4A C4B
15 indeterminate leprosy 9.9 C4A C4B
16 neuropathy 9.9
17 meningitis 9.9
18 optic neuritis 9.9
19 neuritis 9.9
20 acute pancreatitis 9.9
21 antiphospholipid syndrome 9.9
22 pancreatitis 9.9
23 immunodeficiency due to a classical component pathway complement deficiency 9.9 C1R C4A C4B
24 oligoarticular juvenile idiopathic arthritis 9.8 PTPN22 STAT4
25 myocarditis 9.8
26 hemolytic anemia 9.8
27 neuromyelitis optica 9.8
28 blood group--diego system 9.8
29 epiglottitis 9.8
30 cryptococcal meningitis 9.8
31 myositis 9.8
32 anemia, autoimmune hemolytic 9.8
33 aseptic meningitis 9.8
34 hemolytic uremic syndrome, atypical 1 9.8
35 hemolytic-uremic syndrome 9.8
36 aging 9.8
37 ventricular fibrillation, paroxysmal familial, 1 9.8
38 calcinosis 9.8
39 body mass index quantitative trait locus 1 9.8
40 myocardial infarction 9.8
41 myelitis 9.8
42 c1q deficiency 9.8
43 hydrops, lactic acidosis, and sideroblastic anemia 9.8
44 acute myocarditis 9.8
45 acute myocardial infarction 9.8

Graphical network of the top 20 diseases related to Pediatric Systemic Lupus Erythematosus:



Diseases related to Pediatric Systemic Lupus Erythematosus

Symptoms & Phenotypes for Pediatric Systemic Lupus Erythematosus

GenomeRNAi Phenotypes related to Pediatric Systemic Lupus Erythematosus according to GeneCards Suite gene sharing:

25 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.98 TNFSF13B E2F1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.98 E2F1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.98 C4A C4B E2F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.98 C4A C4B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.98 E2F1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.98 E2F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.98 E2F1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.98 C4A C4B
9 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.98 TNFSF13B
10 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.98 C4A C4B TNFSF13B
11 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.98 C4A C4B
12 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.98 TNFSF13B
13 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.98 E2F1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.98 TNFSF13B
15 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.98 TNFSF13B
16 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.98 C4A C4B
17 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.98 C4A C4B
18 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.98 TNFSF13B C4A C4B

MGI Mouse Phenotypes related to Pediatric Systemic Lupus Erythematosus:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 E2F1 IRAK1 MYC PTPN22 SPP1 C3
2 hematopoietic system MP:0005397 9.61 C3 C4B E2F1 IRAK1 MYC PTPN22
3 immune system MP:0005387 9.28 C3 C4B E2F1 IRAK1 MYC PTPN22

Drugs & Therapeutics for Pediatric Systemic Lupus Erythematosus

Drugs for Pediatric Systemic Lupus Erythematosus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2 1406-16-2
2
Cholecalciferol Approved, Nutraceutical Phase 2 67-97-0 10883523 5280795 6221
3
Ergocalciferol Approved, Nutraceutical Phase 2 50-14-6 5280793
4 Micronutrients Phase 2
5 Trace Elements Phase 2
6 Vitamins Phase 2
7 Ergocalciferols Phase 2
8 Interferon-alpha Phase 2
9 Bone Density Conservation Agents Phase 2
10 Vitamin D2 Nutraceutical Phase 2
11 Calciferol Nutraceutical Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vitamin D3 Treatment in Pediatric Systemic Lupus Erythematosus Terminated NCT01709474 Phase 2 Vitamin D3 6000 IU;Vitamin D3 400 IU
2 Health-related Quality of Life Measure in Pediatric Lupus Completed NCT00280137

Search NIH Clinical Center for Pediatric Systemic Lupus Erythematosus

Genetic Tests for Pediatric Systemic Lupus Erythematosus

Anatomical Context for Pediatric Systemic Lupus Erythematosus

MalaCards organs/tissues related to Pediatric Systemic Lupus Erythematosus:

38
Bone, B Cells, Neutrophil, Lung, Spinal Cord

Publications for Pediatric Systemic Lupus Erythematosus

Articles related to Pediatric Systemic Lupus Erythematosus:

(show top 50) (show all 111)
# Title Authors Year
1
DNA induction of MDM2 promotes proliferation of human renal mesangial cells and alters peripheral B cells subsets in pediatric systemic lupus erythematosus. ( 29324237 )
2018
2
Serum IP-10 is useful for identifying renal and overall disease activity in pediatric systemic lupus erythematosus. ( 29264699 )
2017
3
Carotid intima-media thickness and arterial stiffness in pediatric systemic lupus erythematosus. ( 28420050 )
2017
4
Unraveling the expression of microRNA-27a* & NKG2D in peripheral blood mononuclear cells and natural killer cells of pediatric systemic lupus erythematosus patients. ( 28523761 )
2017
5
Efficacy and Safety of Rituximab in the Management of Pediatric Systemic Lupus Erythematosus: A Systematic Review. ( 28602379 )
2017
6
Lenalidomide for refractory cutaneous manifestations of pediatric systemic lupus erythematosus. ( 27837194 )
2016
7
Idiopathic Thrombocytopenic Purpura Masquerading Pediatric Systemic Lupus Erythematosus. ( 27057049 )
2016
8
Alcohol, smoking and illicit drug use in pediatric systemic lupus erythematosus patients. ( 27267641 )
2016
9
Alcohol, smoking and illicit drug use in pediatric systemic lupus erythematosus patients. ( 26949149 )
2016
10
Severe disease presentation and poor outcomes among pediatric systemic lupus erythematosus patients in South Africa. ( 27488473 )
2016
11
An Update on Treatment and Management of Pediatric Systemic Lupus Erythematosus. ( 27747587 )
2016
12
Acute pancreatitis as a cause of mortality in pediatric systemic lupus erythematosus: Results of a multiple cause-of-death analysis in France. ( 27079760 )
2016
13
Targeted B cell therapies in the treatment of adult and pediatric systemic lupus erythematosus. ( 27497253 )
2016
14
High titer anti-basement membrane antibodies in a subset of patients with pediatric systemic lupus erythematosus. ( 25926050 )
2015
15
Pediatric systemic lupus erythematosus presenting with coronary arteritis: A case series and review of the literature. ( 25840624 )
2015
16
Autoantigen microarrays reveal autoantibodies associated with proliferative nephritis and active disease in pediatric systemic lupus erythematosus. ( 26081107 )
2015
17
Targeting E2F1 and c-Myc expression by microRNA-17-5p represses interferon-stimulated gene MxA in peripheral blood mononuclear cells of pediatric systemic lupus erythematosus patients. ( 26175399 )
2015
18
Cytomegalovirus in pediatric systemic lupus erythematosus: prevalence and clinical manifestations. ( 25568145 )
2015
19
Increased activation of toll-like receptors-7 and -8 of peripheral blood mononuclear cells and upregulated serum cytokines in patients with pediatric systemic lupus erythematosus. ( 26884963 )
2015
20
Avascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature. ( 25902709 )
2015
21
Pediatric systemic lupus erythematosus in a single nephrology unit. ( 25758881 )
2015
22
Comorbidities of pediatric systemic lupus erythematosus: A 6-year nationwide population-based study. ( 25066707 )
2014
23
Blood gene expression profiling in pediatric systemic lupus erythematosus and systemic juvenile idiopathic arthritis: from bench to bedside. ( 24839407 )
2014
24
Shrinking lung syndrome complicating pediatric systemic lupus erythematosus. ( 24756252 )
2014
25
National trends in pediatric systemic lupus erythematosus hospitalization in the United States: 2000-2009. ( 24488419 )
2014
26
Cyclophosphamide exposure in pediatric systemic lupus erythematosus is associated with reduced serum anti-mullerian hormone levels. ( 23728191 )
2013
27
Hypogammaglobulinemia in pediatric systemic lupus erythematosus. ( 24106215 )
2013
28
Safety and efficacy of rituximab in refractory pediatric systemic lupus erythematosus nephritis: a single-center experience of Northern Greece. ( 22101555 )
2013
29
Acute myocarditis and ventricular fibrillation as initial presentation of pediatric systemic lupus erythematosus. ( 22119942 )
2013
30
Dyslipidemia in pediatric systemic lupus erythematosus: the relationship with disease activity and plasma homocysteine and cysteine concentrations. ( 23942034 )
2013
31
Dual downregulation of microRNA 17-5p and E2F1 transcriptional factor in pediatric systemic lupus erythematosus patients. ( 23129428 )
2013
32
Reversible splenial lesion syndrome in pediatric systemic lupus erythematosus. ( 22859530 )
2012
33
The complement system in pediatric systemic lupus erythematosus, atypical hemolytic uremic syndrome, and complocentric membranoglomerulopathies. ( 22810363 )
2012
34
Hematological features of pediatric systemic lupus erythematosus: suggesting management strategies in children. ( 22495873 )
2012
35
Defective DNA double-strand break repair in pediatric systemic lupus erythematosus. ( 21905016 )
2012
36
Patterns and influence of familial autoimmunity in pediatric systemic lupus erythematosus. ( 22891746 )
2012
37
Pediatric systemic lupus erythematosus: more than a positive antinuclear antibody. ( 22301032 )
2012
38
Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. ( 21389264 )
2011
39
Measures of disease activity and damage in pediatric systemic lupus erythematosus: British Isles Lupus Assessment Group (BILAG), European Consensus Lupus Activity Measurement (ECLAM), Systemic Lupus Activity Measure (SLAM), Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), Physician's Global Assessment of Disease Activity (MD Global), and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SLICC/ACR DI; SDI). ( 22588739 )
2011
40
High prevalence of myositis in a southeastern United States pediatric systemic lupus erythematosus cohort. ( 21827646 )
2011
41
Bilateral optic neuritis in pediatric systemic lupus erythematosus with antiphospholipid antibody syndrome. ( 20882428 )
2011
42
Measures of health-related quality of life in pediatric systemic lupus erythematosus: Childhood Health Assessment Questionnaire (C-HAQ), Child Health Questionnaire (CHQ), Pediatric Quality of Life Inventory Generic Core Module (PedsQL-GC), Pediatric Quality of Life Inventory Rheumatology Module (PedsQL-RM), and Simple Measure of Impact of Lupus Erythematosus in Youngsters (SMILEY). ( 22588765 )
2011
43
C1q and anti-C1q antibody levels are correlated with disease severity in Chinese pediatric systemic lupus erythematosus. ( 20033414 )
2011
44
Calcinosis cutis universalis with pediatric systemic lupus erythematosus. ( 20130918 )
2010
45
Case series of pediatric systemic lupus erythematosus from Kerala: comparison with other Indian series. ( 21199476 )
2010
46
A proposed framework to standardize the neurocognitive assessment of patients with pediatric systemic lupus erythematosus. ( 20589693 )
2010
47
Pediatric systemic lupus erythematosus in Thammasat University Hospital. ( 21294427 )
2010
48
Bilateral optic neuritis in pediatric systemic lupus erythematosus associated with antiphospholipid antibodies and neuromyelitis optica immunoglobulin. ( 21214161 )
2010
49
Prognostic impact of atypical presentation in pediatric systemic lupus erythematosus: results from a multicenter study. ( 20236656 )
2010
50
Premature atherosclerosis in pediatric systemic lupus erythematosus: risk factors for increased carotid intima-media thickness in the atherosclerosis prevention in pediatric lupus erythematosus cohort. ( 19404953 )
2009

Variations for Pediatric Systemic Lupus Erythematosus

Expression for Pediatric Systemic Lupus Erythematosus

Search GEO for disease gene expression data for Pediatric Systemic Lupus Erythematosus.

Pathways for Pediatric Systemic Lupus Erythematosus

Pathways related to Pediatric Systemic Lupus Erythematosus according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 C1R C3 C4A C4B IRAK1 MX1
2
Show member pathways
12.25 C3 E2F1 MYC STAT4
3 12.22 IRAK1 PTPN22 STAT4 TNFSF13B
4
Show member pathways
11.83 C1R C3 C4A C4B
5 11.77 C1R C3 C4A C4B
6 11.73 E2F1 MYC TNFSF13B
7
Show member pathways
11.68 C1R C3 C4A C4B
8
Show member pathways
11.48 C1R C3 C4A C4B
9 11 C1R C3 C4A C4B
10 10.9 C1R C3 C4A C4B IRAK1
11 10.84 E2F1 MYC

GO Terms for Pediatric Systemic Lupus Erythematosus

Cellular components related to Pediatric Systemic Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 C1R C3 C4A C4B MIR17 SPP1
2 blood microparticle GO:0072562 8.92 C1R C3 C4A C4B

Biological processes related to Pediatric Systemic Lupus Erythematosus according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.8 C3 C4A C4B SPP1
2 innate immune response GO:0045087 9.73 C1R C3 C4A C4B IRAK1 MX1
3 negative regulation of gene expression GO:0010629 9.7 MIR17 MYC PTPN22
4 complement activation, classical pathway GO:0006958 9.67 C1R C3 C4A C4B
5 negative regulation of endopeptidase activity GO:0010951 9.65 C3 C4A C4B
6 cellular response to hypoxia GO:0071456 9.63 E2F1 IRAK1 MYC
7 regulation of complement activation GO:0030449 9.62 C1R C3 C4A C4B
8 positive regulation of fibroblast proliferation GO:0048146 9.58 E2F1 MIR17 MYC
9 lipopolysaccharide-mediated signaling pathway GO:0031663 9.51 IRAK1 PTPN22
10 complement activation GO:0006956 9.46 C1R C3 C4A C4B
11 cellular response to testosterone stimulus GO:0071394 9.43 MYC SPP1
12 immune system process GO:0002376 9.17 C3 C4A C4B IRAK1 MX1 PTPN22
13 positive regulation of apoptotic cell clearance GO:2000427 9.13 C3 C4A C4B

Molecular functions related to Pediatric Systemic Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.26 C1R C3 C4A C4B
2 endopeptidase inhibitor activity GO:0004866 8.8 C3 C4A C4B

Sources for Pediatric Systemic Lupus Erythematosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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