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Pediatric Systemic Lupus Erythematosus malady

Neuronal diseases, Nephrological diseases, Respiratory diseases, Bone diseases, Rare diseases categories
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Summaries for Pediatric Systemic Lupus Erythematosus

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MalaCards based summary: Pediatric Systemic Lupus Erythematosus, also known as sle, pediatric onset, is related to lupus erythematosus and arthritis. An important gene associated with Pediatric Systemic Lupus Erythematosus is STAT4 (signal transducer and activator of transcription 4), and among its related pathways are 14-3-3 and Regulation of BAD Activity and EBV LMP1 signaling. The compounds tab-1 and mycophenolic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and lung, and related mouse phenotypes are renal/urinary system and adipose tissue.

Aliases & Classifications for Pediatric Systemic Lupus Erythematosus

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48Orphanet, 26ICD10 via Orphanet
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Related Diseases for Pediatric Systemic Lupus Erythematosus

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Diseases related to Pediatric Systemic Lupus Erythematosus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus32.3C4A, APOH, C3
2arthritis31.2TNFRSF1A, TNF
3calcinosis30.9SPP1
4antiphospholipid syndrome30.9VCAM1, APOH
5nephritis30.5TNFSF13B, C4A, C3, VCAM1, APOH
6systemic lupus erythematosus29.9TNFRSF1A, TNFSF13B, SPP1, PTPN22, APOH, VCAM1
7atherosclerosis29.5SPP1, TNF, C3, ICAM1, IRAK1, VCAM1
8retinal vasculitis10.5APOH
9retinal artery occlusion10.5APOH
10thrombocytopenia10.5
11complement deficiency10.4C4A, C3
12coronary restenosis10.4SPP1
13meningitis10.4
14neuritis10.4
15neuropathy10.4
16optic neuritis10.4
17peripheral neuropathy10.4
18purpura10.4
19leishmaniasis10.4TNFRSF1A
20severe pre-eclampsia10.4VCAM1, APOH
21rheumatoid vasculitis10.4ICAM1, VCAM1
22leukostasis10.4ICAM1, VCAM1
23periodic fever, familial, autosomal dominant10.4TNF, TNFRSF1A
24arteriosclerosis obliterans10.4ICAM1, VCAM1
25immunoglobulin a vasculitis10.4ICAM1, VCAM1
26inclusion body myositis10.4ICAM1, VCAM1
27oral lichen planus10.3ICAM1, VCAM1
28common variable immunodeficiency10.3TNFSF13B, TNFRSF1A
29familial mediterranean fever10.3TNF, TNFRSF1A
30vernal keratoconjunctivitis10.3ICAM1, VCAM1
31alcoholic hepatitis10.3TNF, ICAM1
32sjogren's syndrome10.3ICAM1, TNFSF13B, APOH
33sudden infant death syndrome10.3C4A, C4B
34ameloblastoma10.2TNFRSF1A, E2F1
35chronic lymphocytic leukemia10.2TNFSF13B, ICAM1, TNFRSF1A
36acute myocardial infarction10.2
37hemolytic anemia10.2
38myocardial infarction10.2
39neuromyelitis optica10.2
40myelitis10.2
41autoimmune hemolytic anemia10.2
42epiglottitis10.2
43hemolytic-uremic syndrome10.2
44aseptic meningitis10.2
45acute myocarditis10.2
46myocarditis10.2
47myositis10.2
48atypical hemolytic-uremic syndrome10.2
49thromboembolism10.2
50c1q deficiency10.2

Graphical network of the top 20 diseases related to Pediatric Systemic Lupus Erythematosus:



Diseases related to pediatric systemic lupus erythematosus

Symptoms for Pediatric Systemic Lupus Erythematosus

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Drugs & Therapeutics for Pediatric Systemic Lupus Erythematosus

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Drug clinical trials:

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Genetic Tests for Pediatric Systemic Lupus Erythematosus

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Anatomical Context for Pediatric Systemic Lupus Erythematosus

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MalaCards organs/tissues related to Pediatric Systemic Lupus Erythematosus:

32
Bone, Spinal cord, Lung, B cells, Neutrophil

Animal Models for Pediatric Systemic Lupus Erythematosus or affiliated genes

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Publications for Pediatric Systemic Lupus Erythematosus

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Articles related to Pediatric Systemic Lupus Erythematosus:

(show top 50)    (show all 88)
idTitleAuthorsYear
1
National trends in pediatric systemic lupus erythematosus hospitalization in the United States: 2000-2009. (24488419)
2014
2
Comorbidities of pediatric systemic lupus erythematosus: A 6-year nationwide population-based study. (25066707)
2014
3
Blood gene expression profiling in pediatric systemic lupus erythematosus and systemic juvenile idiopathic arthritis: from bench to bedside. (24839407)
2014
4
Shrinking lung syndrome complicating pediatric systemic lupus erythematosus. (24756252)
2014
5
Hypogammaglobulinemia in pediatric systemic lupus erythematosus. (24106215)
2013
6
Dual downregulation of microRNA 17-5p and E2F1 transcriptional factor in pediatric systemic lupus erythematosus patients. (23129428)
2013
7
Safety and efficacy of rituximab in refractory pediatric systemic lupus erythematosus nephritis: a single-center experience of Northern Greece. (22101555)
2013
8
Reversible splenial lesion syndrome in pediatric systemic lupus erythematosus. (22859530)
2012
9
Defective DNA double-strand break repair in pediatric systemic lupus erythematosus. (21905016)
2012
10
Bilateral optic neuritis in pediatric systemic lupus erythematosus with antiphospholipid antibody syndrome. (20882428)
2011
11
Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. (21389264)
2011
12
Measures of disease activity and damage in pediatric systemic lupus erythematosus: British Isles Lupus Assessment Group (BILAG), European Consensus Lupus Activity Measurement (ECLAM), Systemic Lupus Activity Measure (SLAM), Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), Physician's Global Assessment of Disease Activity (MD Global), and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SLICC/ACR DI; SDI). (22588739)
2011
13
Case series of pediatric systemic lupus erythematosus from Kerala: comparison with other Indian series. (21199476)
2010
14
A proposed framework to standardize the neurocognitive assessment of patients with pediatric systemic lupus erythematosus. (20589693)
2010
15
Prognostic impact of atypical presentation in pediatric systemic lupus erythematosus: results from a multicenter study. (20236656)
2010
16
Calcinosis cutis universalis with pediatric systemic lupus erythematosus. (20130918)
2010
17
Acute epiglottitis as the initial presentation of pediatric Systemic Lupus Erythematosus. (19878586)
2009
18
Premature atherosclerosis in pediatric systemic lupus erythematosus: risk factors for increased carotid intima-media thickness in the atherosclerosis prevention in pediatric lupus erythematosus cohort. (19404953)
2009
19
B-cell depletion for autoimmune thrombocytopenia and autoimmune hemolytic anemia in pediatric systemic lupus erythematosus. (19074962)
2009
20
Longitudinal myelitis, aseptic meningitis, and conus medullaris infarction as presenting manifestations of pediatric systemic lupus erythematosus. (18413416)
2008
21
MAGE-B2 autoantibody: a new biomarker for pediatric systemic lupus erythematosus. (19004030)
2008
22
Therapy Insight: cardiovascular disease in pediatric systemic lupus erythematosus. (18349862)
2008
23
Measuring permanent damage in pediatric systemic lupus erythematosus. (17711904)
2007
24
Flares in pediatric systemic lupus erythematosus. (17477466)
2007
25
Urine macrophage migration inhibitory factor in pediatric systemic lupus erythematosus. (17479310)
2007
26
Longitudinal examination of lipid profiles in pediatric systemic lupus erythematosus. (17265498)
2007
27
Pediatric systemic lupus erythematosus with C1q deficiency. (17893985)
2007
28
Neuropsychiatric involvement in pediatric systemic lupus erythematosus. (17711889)
2007
29
Antiphospholipid antibodies in pediatric systemic lupus erythematosus and the antiphospholipid syndrome. (17711899)
2007
30
Three distinct profiles of serum complement C4 proteins in pediatric systemic lupus erythematosus (SLE) patients: tight associations of complement C4 and C3 protein levels in SLE but not in healthy subjects. (16893076)
2006
31
Neuropsychiatric manifestations in pediatric systemic lupus erythematosus and association with antiphospholipid antibodies. (16845706)
2006
32
Pediatric systemic lupus erythematosus in Siriraj Hospital. (16858852)
2005
33
Hypovolemic shock as an initial presentation of pediatric systemic lupus erythematosus. (15910467)
2005
34
Update on pediatric systemic lupus erythematosus. (15314498)
2004
35
Peripheral neuropathy in pediatric systemic lupus erythematosus. (12770683)
2003
36
Peripheral neuropathy in pediatric systemic lupus erythematosus. (12160975)
2002
37
Tumor necrosis factor induced adhesion molecule serum concentrations in Henoch-SchAPnlein purpura and pediatric systemic lupus erythematosus. (10990243)
2000
38
Neurologic, ophthalmic, and neuropsychiatric manifestations of pediatric systemic lupus erythematosus. (10966064)
2000
39
Sex differences in pediatric systemic lupus erythematosus: a retrospective analysis of 135 cases. (10637715)
1999
40
Differences in tumor necrosis factor-alpha soluble receptor serum concentrations between patients with Henoch-SchAPnlein purpura and pediatric systemic lupus erythematosus: pathogenetic implications. (9489835)
1998
41
A case of pediatric systemic lupus erythematosus with early onset and unusual serologic and clinical findings. (9558773)
1997
42
Catastrophic antiphospholipid antibody syndrome in pediatric systemic lupus erythematosus. (9035002)
1997
43
Antiphospholipid antibodies in pediatric systemic lupus erythematosus. (7491218)
1995
44
Neurologic manifestations of pediatric systemic lupus erythematosus. (8554655)
1995
45
Anticardiolipin antibodies in pediatric systemic lupus erythematosus. (8148941)
1994
46
Pediatric systemic lupus erythematosus and neonatal lupus. (8153396)
1994
47
Acute myocardial infarction in pediatric systemic lupus erythematosus. (2380828)
1990
48
Neuropsychologic deficits and antineuronal antibodies in pediatric systemic lupus erythematosus. (2397630)
1990
49
Dyslipoproteinemia in pediatric systemic lupus erythematosus. (3134897)
1988
50
Perspectives in pediatric systemic lupus erythematosus. (3612646)
1987

Variations for Pediatric Systemic Lupus Erythematosus

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Expression for genes affiliated with Pediatric Systemic Lupus Erythematosus

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Expression patterns in normal tissues for genes affiliated with Pediatric Systemic Lupus Erythematosus

Search GEO for disease gene expression data for Pediatric Systemic Lupus Erythematosus.

Pathways for genes affiliated with Pediatric Systemic Lupus Erythematosus

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Pathways related to Pediatric Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 46)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1TNFRSF1A
29.6TNF, IRAK1
3
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
9.5C3, C4A, C4B
4
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.5C3, C4A, C4B
59.4TNFRSF1A, TNF
6
Show member pathways
9.4TNFRSF1A, TNF
7
Show member pathways
9.4TNFRSF1A, TNF
8
Show member pathways
9.4TNFRSF1A, TNF
99.4VCAM1, PTPN22, TNFSF13B
109.4TNF, VCAM1
119.3TNF, C4A, C4B
129.2SPP1, VCAM1, ICAM1
13
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
9.2IRAK1, TNFRSF1A, TNF
14
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.2IRAK1, TNFRSF1A, TNF
159.2TNF, TNFRSF1A, IRAK1
16
Show member pathways
9.2TNF, TNFRSF1A, IRAK1
17
Show member pathways
RANKL/RANK Signaling Pathway37
Apoptosis and survival APRIL and BAFF signaling60
9.2ICAM1, VCAM1, TNFSF13B
189.1C3, ICAM1, VCAM1
19
Show member pathways
9.1TNFRSF1A, TNF, TNFSF13B
20
Show member pathways
9.0SPP1, VCAM1, ICAM1, STAT4
219.0C4B, C4A, C3, ICAM1
229.0TNFSF13B, TNF, ICAM1
238.9TNF, TNFRSF1A, E2F1
24
Show member pathways
8.9TNF, C3, C4A, C4B
258.9ICAM1, VCAM1, TNF
268.9ICAM1, VCAM1, TNF
278.9ICAM1, VCAM1, TNF
288.9ICAM1, VCAM1, TNF
29
Show member pathways
8.9TNFSF13B, TNF, TNFRSF1A, STAT4
30
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway60
8.9IRAK1, TNFRSF1A, TNF, TNFSF13B
31
Show member pathways
8.9TNFSF13B, TNF, TNFRSF1A, IRAK1
32
Show member pathways
8.9TNFSF13B, TNF, TNFRSF1A, IRAK1
33
Show member pathways
8.8PTPN22, TNFRSF1A, TNF, TNFSF13B
348.8TNF, TNFRSF1A, IRAK1, C3
358.7TNF, IRAK1, C3, C4A, C4B
36
Show member pathways
8.6TNFSF13B, TNF, TNFRSF1A, IRAK1, STAT4
37
Show member pathways
8.6TNF, TNFRSF1A, IRAK1, STAT4, C3
388.5ICAM1, VCAM1, TNFRSF1A, TNF
398.5TNFSF13B, TNF, E2F1, ICAM1
40
Show member pathways
8.3TNF, TNFRSF1A, IRAK1, ICAM1, C3
41
Show member pathways
8.3TNFSF13B, TNF, TNFRSF1A, ICAM1, C4A
42
Show member pathways
8.2SPP1, TNF, TNFRSF1A, E2F1, IRAK1, STAT4
437.9TNF, TNFRSF1A, E2F1, VCAM1, ICAM1
447.9ICAM1, IRAK1, VCAM1, TNFRSF1A, TNF, TNFSF13B
45
Show member pathways
7.8SPP1, TNFSF13B, TNF, TNFRSF1A, E2F1, IRAK1
46
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
7.8SPP1, TNF, TNFRSF1A, E2F1, IRAK1, STAT4

Compounds for genes affiliated with Pediatric Systemic Lupus Erythematosus

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Compounds related to Pediatric Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1tab-1449.6IRAK1, TNFRSF1A, TNF
2mycophenolic acid44 50 1111.6VCAM1, SPP1, ICAM1
3txb2449.5APOH, IRAK1, C4A
4agarose449.5APOH, C4B, C4A, C3
5bcma449.5TNFSF13B, TNFRSF1A, TNF
6blys449.5TNFRSF1A, TNF, TNFSF13B
7lipoteichoic acid449.5APOH, TNF, IRAK1
8cuprophan449.4TNFRSF1A, VCAM1, ICAM1
9infliximab44 50 1111.3APOH, TNFRSF1A, TNF, SPP1
10apocynin44 6110.2VCAM1, TNF, ICAM1
11polymyxin b449.2VCAM1, TNF, ICAM1
12groalpha449.1VCAM1, TNF, ICAM1
13budesonide44 50 1111.1TNF, VCAM1, ICAM1
14etanercept44 50 1111.1APOH, TNFRSF1A, TNF
15parthenolide44 210.1ICAM1, VCAM1, TNF
168-isoprostane449.0APOH, VCAM1, ICAM1, TNF
17troglitazone44 28 61 1112.0ICAM1, SPP1, TNF, VCAM1
18neopterin448.9TNF, C3, TNFRSF1A, ICAM1
19creatinine448.9C3, APOH, TNFRSF1A, TNFSF13B, SPP1
20okt3448.9TNFRSF1A, VCAM1, ICAM1, TNF
21sp 60012544 619.8TNF, ICAM1, VCAM1, TNFRSF1A
22simvastatin44 50 61 28 24 1113.8TNFRSF1A, TNF, ICAM1, VCAM1
23heparin44 28 24 1111.7C4B, C3, VCAM1, TNFRSF1A, SPP1, APOH
24genistein44 28 61 2 24 1113.7SPP1, VCAM1, ICAM1, IRAK1, TNF
25fmlp448.7TNFRSF1A, ICAM1, TNF, VCAM1
26tgf beta1448.6TNFRSF1A, SPP1, VCAM1, E2F1, TNF
27herbimycin a44 619.6VCAM1, TNFRSF1A, TNF, SPP1, ICAM1
28curcumin448.6TNF, VCAM1, TNFRSF1A, SPP1, ICAM1
29superoxide44 249.6APOH, TNFRSF1A, VCAM1, TNF, SPP1
30rantes448.6VCAM1, TNFRSF1A, TNF, IRAK1, ICAM1
31methotrexate50 44 1110.6APOH, TNFRSF1A, TNF, E2F1
32sb 20358044 619.6VCAM1, ICAM1, TNFRSF1A, TNF, SPP1
33prostacyclin448.6ICAM1, TNF, TNFRSF1A, APOH, VCAM1
34alanine448.5IRAK1, VCAM1, TNFRSF1A, TNFSF13B, SPP1, E2F1
35actinomycin d448.5TNFRSF1A, E2F1, TNF, SPP1, ICAM1
36pge2448.5VCAM1, TNFRSF1A, SPP1, ICAM1, TNF
37fibrinogen448.4APOH, C3, ICAM1, VCAM1, SPP1, TNF
38lactate448.3SPP1, TNF, APOH, VCAM1, ICAM1, C3
39estrogen448.2TNFRSF1A, SPP1, C3, VCAM1, E2F1, APOH
40endotoxin448.1C4A, VCAM1, APOH, ICAM1, TNFRSF1A, TNF
41dexamethasone44 50 28 1111.0VCAM1, TNF, SPP1, STAT4, C3, ICAM1
42tyrosine447.9STAT4, IRAK1, SPP1, TNFRSF1A, E2F1, VCAM1
43cycloheximide447.8TNF, SPP1, TNFRSF1A, ICAM1, E2F1
44nitric oxide44 24 119.8TNFRSF1A, TNF, APOH, E2F1, VCAM1, ICAM1
45vegf447.8APOH, ICAM1, VCAM1, TNFRSF1A, TNF, SPP1
46retinoic acid44 248.7E2F1, TNFRSF1A, SPP1, VCAM1, TNF, ICAM1
47lipid447.7TNFRSF1A, TNF, SPP1, E2F1, APOH, VCAM1
48phosphatidylinositol447.6IRAK1, ICAM1, E2F1, STAT4, C3, APOH
49serine447.2TNF, C4B, C3, STAT4, IRAK1, VCAM1
50oxygen44 247.9TNF, TNFRSF1A, SPP1, APOH, C4A, E2F1

GO Terms for genes affiliated with Pediatric Systemic Lupus Erythematosus

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Cellular components related to Pediatric Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.2C4B, C4A, C3
2external side of plasma membraneGO:0098978.9ICAM1, VCAM1, TNF
3cell surfaceGO:0099868.6TNF, TNFRSF1A, APOH, VCAM1
4extracellular regionGO:0055768.2SPP1, TNF, TNFRSF1A, C3, C4A, C4B
5extracellular spaceGO:0056157.3C3, SPP1, TNFSF13B, TNF, TNFRSF1A, APOH
6plasma membraneGO:0058867.0TNFSF13B, TNF, TNFRSF1A, VCAM1, IRAK1, ICAM1

Biological processes related to Pediatric Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1regulation of complement activationGO:0304499.9C4B, C4A, C3
2complement activationGO:0069569.9C3, C4A, C4B
3complement activation, classical pathwayGO:0069589.9C4B, C4A, C3
4membrane to membrane dockingGO:0226149.8ICAM1, VCAM1
5response to amino acidGO:0432009.7ICAM1, TNFRSF1A
6lipopolysaccharide-mediated signaling pathwayGO:0316639.7IRAK1, TNF
7leukocyte tethering or rollingGO:0509019.7TNF, VCAM1
8response to lipopolysaccharideGO:0324969.6IRAK1, VCAM1, TNFRSF1A
9negative regulation of interleukin-6 productionGO:0327159.6TNF, TNFRSF1A
10leukocyte cell-cell adhesionGO:0071599.6ICAM1, VCAM1
11cellular response to glucose stimulusGO:0713339.5ICAM1, VCAM1
12cellular response to hypoxiaGO:0714569.5ICAM1, IRAK1, E2F1
13positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.4IRAK1, TNFRSF1A, TNF
14regulation of immune responseGO:0507769.4C3, ICAM1, VCAM1
15heterophilic cell-cell adhesionGO:0071579.4ICAM1, VCAM1
16response to ethanolGO:0454719.4TNFRSF1A, VCAM1, ICAM1
17positive regulation of nitric oxide biosynthetic processGO:0454299.3TNF, ICAM1
18positive regulation of NF-kappaB transcription factor activityGO:0510929.3TNF, IRAK1, ICAM1
19intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.3E2F1, TNFRSF1A, TNF
20cytokine-mediated signaling pathwayGO:0192219.2TNFRSF1A, VCAM1, ICAM1, STAT4
21response to hypoxiaGO:0016669.2VCAM1, TNFRSF1A, TNF
22innate immune responseGO:0450879.0C4B, C4A, C3, IRAK1
23extracellular matrix organizationGO:0301988.9SPP1, TNF, VCAM1, ICAM1
24positive regulation of transcription from RNA polymerase II promoterGO:0459448.8TNF, TNFRSF1A, E2F1, IRAK1, STAT4
25inflammatory responseGO:0069548.6C4B, SPP1, TNF, TNFRSF1A, C3, C4A

Molecular functions related to Pediatric Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:0048669.5C4B, C4A, C3
2tumor necrosis factor receptor bindingGO:0051649.2TNFSF13B, TNF
3cytokine activityGO:0051259.1TNF, TNFSF13B, SPP1
4protein bindingGO:0055156.9TNF, TNFRSF1A, PTPN22, APOH, E2F1, IRAK1

Products for genes affiliated with Pediatric Systemic Lupus Erythematosus

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Sources for Pediatric Systemic Lupus Erythematosus

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3CDC
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14FMA
22GTR
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24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
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40NDF-RT
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58SNOMED-CT via Orphanet
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