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Pediatric Systemic Lupus Erythematosus malady

Neuronal diseases, Nephrological diseases, Respiratory diseases, Bone diseases, Rare diseases categories

Summaries for Pediatric Systemic Lupus Erythematosus

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34MalaCards
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MalaCards: Pediatric Systemic Lupus Erythematosus, also known as sle, pediatric onset, is related to lupus erythematosus and systemic lupus erythematosus. An important gene associated with Pediatric Systemic Lupus Erythematosus is STAT4 (signal transducer and activator of transcription 4), and among its related pathways are 14-3-3 and Regulation of BAD Activity and EBV LMP1 signaling. The compounds tab-1 and mycophenolic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and b cells, and related mouse phenotypes are renal/urinary system and adipose tissue.

Aliases & Classifications for Pediatric Systemic Lupus Erythematosus

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50Orphanet, 27ICD10 via Orphanet
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Related Diseases for Pediatric Systemic Lupus Erythematosus

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18GeneCards, 19GeneDecks
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Diseases related to Pediatric Systemic Lupus Erythematosus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus31.9C4A, APOH, C3
2systemic lupus erythematosus31.3TNFRSF1A, TNFSF13B, SPP1, PTPN22, APOH, VCAM1
3arthritis30.7TNFRSF1A, TNF
4antiphospholipid syndrome30.6VCAM1, APOH
5calcinosis30.5SPP1
6nephritis30.4TNFSF13B, C4A, C3, VCAM1, APOH
7atherosclerosis30.3SPP1, TNF, C3, ICAM1, IRAK1, VCAM1
8thrombocytopenia10.5
9meningitis10.4
10neuritis10.4
11neuropathy10.4
12optic neuritis10.4
13peripheral neuropathy10.4
14purpura10.4
15neuromyelitis optica10.2
16myelitis10.2
17acute pancreatitis10.2
18epiglottitis10.2
19autoimmune hemolytic anemia10.2
20hemolytic-uremic syndrome10.2
21aseptic meningitis10.2
22acute myocardial infarction10.2
23acute myocarditis10.2
24hemolytic anemia10.2
25myocardial infarction10.2
26myocarditis10.2
27myositis10.2
28pancreatitis10.2
29atypical hemolytic-uremic syndrome10.2
30thromboembolism10.2
31c1q deficiency10.2
32systemic lupus erythematosus, association with10.2
33retinal vasculitis10.1APOH
34retinal artery occlusion10.1APOH
35complement deficiency10.1C4A, C3
36coronary restenosis10.1SPP1
37leishmaniasis10.1TNFRSF1A
38severe pre-eclampsia10.1VCAM1, APOH
39rheumatoid vasculitis10.1ICAM1, VCAM1
40leukostasis10.1ICAM1, VCAM1
41periodic fever, familial, autosomal dominant10.1TNF, TNFRSF1A
42arteriosclerosis obliterans10.1ICAM1, VCAM1
43immunoglobulin a vasculitis10.1ICAM1, VCAM1
44inclusion body myositis10.1ICAM1, VCAM1
45oral lichen planus10.1ICAM1, VCAM1
46common variable immune deficiency10.1TNFSF13B, TNFRSF1A
47familial mediterranean fever10.1TNF, TNFRSF1A
48vernal keratoconjunctivitis10.1ICAM1, VCAM1
49alcoholic hepatitis10.1TNF, ICAM1
50sjogren's syndrome10.1ICAM1, TNFSF13B, APOH

Graphical network of the top 20 diseases related to Pediatric Systemic Lupus Erythematosus:



Diseases related to pediatric systemic lupus erythematosus

Symptoms for Pediatric Systemic Lupus Erythematosus

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Drugs & Therapeutics for Pediatric Systemic Lupus Erythematosus

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Genetic Tests for Pediatric Systemic Lupus Erythematosus

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Anatomical Context for Pediatric Systemic Lupus Erythematosus

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34MalaCards
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MalaCards organs/tissues related to Pediatric Systemic Lupus Erythematosus:

34
Bone, Spinal cord, B cells

Animal Models for Pediatric Systemic Lupus Erythematosus or affiliated genes

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38MGI
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Publications for Pediatric Systemic Lupus Erythematosus

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53PubMed
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Articles related to Pediatric Systemic Lupus Erythematosus:

(show top 50)    (show all 86)
idTitleAuthorsYear
1
Hypogammaglobulinemia in pediatric systemic lupus erythematosus. (24106215)
2013
2
Dual downregulation of microRNA 17-5p and E2F1 transcriptional factor in pediatric systemic lupus erythematosus patients. (23129428)
2013
3
Safety and efficacy of rituximab in refractory pediatric systemic lupus erythematosus nephritis: a single-center experience of Northern Greece. (22101555)
2013
4
Reversible splenial lesion syndrome in pediatric systemic lupus erythematosus. (22859530)
2012
5
Defective DNA double-strand break repair in pediatric systemic lupus erythematosus. (21905016)
2012
6
Bilateral optic neuritis in pediatric systemic lupus erythematosus with antiphospholipid antibody syndrome. (20882428)
2011
7
Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. (21389264)
2011
8
Measures of disease activity and damage in pediatric systemic lupus erythematosus: British Isles Lupus Assessment Group (BILAG), European Consensus Lupus Activity Measurement (ECLAM), Systemic Lupus Activity Measure (SLAM), Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), Physician's Global Assessment of Disease Activity (MD Global), and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SLICC/ACR DI; SDI). (22588739)
2011
9
Case series of pediatric systemic lupus erythematosus from Kerala: comparison with other Indian series. (21199476)
2010
10
A proposed framework to standardize the neurocognitive assessment of patients with pediatric systemic lupus erythematosus. (20589693)
2010
11
Prognostic impact of atypical presentation in pediatric systemic lupus erythematosus: results from a multicenter study. (20236656)
2010
12
Calcinosis cutis universalis with pediatric systemic lupus erythematosus. (20130918)
2010
13
Acute epiglottitis as the initial presentation of pediatric Systemic Lupus Erythematosus. (19878586)
2009
14
Premature atherosclerosis in pediatric systemic lupus erythematosus: risk factors for increased carotid intima-media thickness in the atherosclerosis prevention in pediatric lupus erythematosus cohort. (19404953)
2009
15
Acute pancreatitis as the initial presentation in pediatric systemic lupus erythematosus. (19475344)
2009
16
B-cell depletion for autoimmune thrombocytopenia and autoimmune hemolytic anemia in pediatric systemic lupus erythematosus. (19074962)
2009
17
Longitudinal myelitis, aseptic meningitis, and conus medullaris infarction as presenting manifestations of pediatric systemic lupus erythematosus. (18413416)
2008
18
MAGE-B2 autoantibody: a new biomarker for pediatric systemic lupus erythematosus. (19004030)
2008
19
Therapy Insight: cardiovascular disease in pediatric systemic lupus erythematosus. (18349862)
2008
20
Remitting symmetrical pitting edema of hands and feet at onset of pediatric systemic lupus erythematosus: a case report. (19210895)
2008
21
Measuring permanent damage in pediatric systemic lupus erythematosus. (17711904)
2007
22
Flares in pediatric systemic lupus erythematosus. (17477466)
2007
23
Urine macrophage migration inhibitory factor in pediatric systemic lupus erythematosus. (17479310)
2007
24
Outcome of a national Israeli cohort of pediatric systemic lupus erythematosus. (17402372)
2007
25
Longitudinal examination of lipid profiles in pediatric systemic lupus erythematosus. (17265498)
2007
26
Pediatric systemic lupus erythematosus with C1q deficiency. (17893985)
2007
27
Neuropsychiatric involvement in pediatric systemic lupus erythematosus. (17711889)
2007
28
Antiphospholipid antibodies in pediatric systemic lupus erythematosus and the antiphospholipid syndrome. (17711899)
2007
29
Three distinct profiles of serum complement C4 proteins in pediatric systemic lupus erythematosus (SLE) patients: tight associations of complement C4 and C3 protein levels in SLE but not in healthy subjects. (16893076)
2006
30
Neuropsychiatric manifestations in pediatric systemic lupus erythematosus and association with antiphospholipid antibodies. (16845706)
2006
31
Pediatric systemic lupus erythematosus in Siriraj Hospital. (16858852)
2005
32
Hypovolemic shock as an initial presentation of pediatric systemic lupus erythematosus. (15910467)
2005
33
Update on pediatric systemic lupus erythematosus. (15314498)
2004
34
Peripheral neuropathy in pediatric systemic lupus erythematosus. (12770683)
2003
35
Peripheral neuropathy in pediatric systemic lupus erythematosus. (12160975)
2002
36
Anti-beta2-glycoprotein I antibodies in pediatric systemic lupus erythematosus and antiphospholipid syndrome. (12209489)
2002
37
Tumor necrosis factor induced adhesion molecule serum concentrations in Henoch-SchAPnlein purpura and pediatric systemic lupus erythematosus. (10990243)
2000
38
Neurologic, ophthalmic, and neuropsychiatric manifestations of pediatric systemic lupus erythematosus. (10966064)
2000
39
Sex differences in pediatric systemic lupus erythematosus: a retrospective analysis of 135 cases. (10637715)
1999
40
Differences in tumor necrosis factor-alpha soluble receptor serum concentrations between patients with Henoch-SchAPnlein purpura and pediatric systemic lupus erythematosus: pathogenetic implications. (9489835)
1998
41
A case of pediatric systemic lupus erythematosus with early onset and unusual serologic and clinical findings. (9558773)
1997
42
Catastrophic antiphospholipid antibody syndrome in pediatric systemic lupus erythematosus. (9035002)
1997
43
Antiphospholipid antibodies in pediatric systemic lupus erythematosus. (7491218)
1995
44
Neurologic manifestations of pediatric systemic lupus erythematosus. (8554655)
1995
45
Anticardiolipin antibodies in pediatric systemic lupus erythematosus. (8148941)
1994
46
Pediatric systemic lupus erythematosus and neonatal lupus. (8153396)
1994
47
Acute myocardial infarction in pediatric systemic lupus erythematosus. (2380828)
1990
48
Neuropsychologic deficits and antineuronal antibodies in pediatric systemic lupus erythematosus. (2397630)
1990
49
Dyslipoproteinemia in pediatric systemic lupus erythematosus. (3134897)
1988
50
Perspectives in pediatric systemic lupus erythematosus. (3612646)
1987

Variations for Pediatric Systemic Lupus Erythematosus

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Expression for genes affiliated with Pediatric Systemic Lupus Erythematosus

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pediatric Systemic Lupus Erythematosus

Search GEO for disease gene expression data for Pediatric Systemic Lupus Erythematosus.

Pathways for genes affiliated with Pediatric Systemic Lupus Erythematosus

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51PathCards, 54QIAGEN, 39NCBI BioSystems Database, 31KEGG, 61Thomson Reuters, 56Reactome, 58SinoBiological, 55R&D Systems, 5Cell Signaling Technology
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Pathways related to Pediatric Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 46)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1TNFRSF1A
29.6TNF, IRAK1
3
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
9.5C3, C4A, C4B
4
Show member pathways
Immune response Alternative complement pathway61
Immune response Lectin Induced complement pathway61
Immune response Classic complement pathway61
9.5C3, C4A, C4B
59.4TNFRSF1A, TNF
6
Show member pathways
9.4TNFRSF1A, TNF
7
Show member pathways
9.4TNFRSF1A, TNF
8
Show member pathways
9.4TNFRSF1A, TNF
99.4VCAM1, PTPN22, TNFSF13B
109.4TNF, VCAM1
119.3TNF, C4A, C4B
129.2SPP1, VCAM1, ICAM1
13
Show member pathways
Apoptosis Modulation and Signaling39
Apoptosis39
9.2IRAK1, TNFRSF1A, TNF
14
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.2IRAK1, TNFRSF1A, TNF
159.2TNF, TNFRSF1A, IRAK1
16
Show member pathways
9.2TNF, TNFRSF1A, IRAK1
17
Show member pathways
RANKL/RANK Signaling Pathway39
Apoptosis and survival APRIL and BAFF signaling61
9.2ICAM1, VCAM1, TNFSF13B
189.1C3, ICAM1, VCAM1
19
Show member pathways
9.1TNFRSF1A, TNF, TNFSF13B
20
Show member pathways
9.0SPP1, VCAM1, ICAM1, STAT4
219.0C4B, C4A, C3, ICAM1
229.0TNFSF13B, TNF, ICAM1
238.9TNF, TNFRSF1A, E2F1
24
Show member pathways
8.9TNF, C3, C4A, C4B
258.9ICAM1, VCAM1, TNF
268.9ICAM1, VCAM1, TNF
278.9ICAM1, VCAM1, TNF
288.9ICAM1, VCAM1, TNF
29
Show member pathways
8.9TNFSF13B, TNF, TNFRSF1A, STAT4
30
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway61
8.9IRAK1, TNFRSF1A, TNF, TNFSF13B
31
Show member pathways
8.9TNFSF13B, TNF, TNFRSF1A, IRAK1
32
Show member pathways
8.9TNFSF13B, TNF, TNFRSF1A, IRAK1
33
Show member pathways
8.8PTPN22, TNFRSF1A, TNF, TNFSF13B
348.8TNF, TNFRSF1A, IRAK1, C3
358.7TNF, IRAK1, C3, C4A, C4B
36
Show member pathways
8.6TNFSF13B, TNF, TNFRSF1A, IRAK1, STAT4
37
Show member pathways
8.6TNF, TNFRSF1A, IRAK1, STAT4, C3
388.5ICAM1, VCAM1, TNFRSF1A, TNF
398.5TNFSF13B, TNF, E2F1, ICAM1
40
Show member pathways
8.3TNF, TNFRSF1A, IRAK1, ICAM1, C3
41
Show member pathways
8.3TNFSF13B, TNF, TNFRSF1A, ICAM1, C4A
42
Show member pathways
8.2SPP1, TNF, TNFRSF1A, E2F1, IRAK1, STAT4
437.9TNF, TNFRSF1A, E2F1, VCAM1, ICAM1
447.9ICAM1, IRAK1, VCAM1, TNFRSF1A, TNF, TNFSF13B
45
Show member pathways
7.8SPP1, TNFSF13B, TNF, TNFRSF1A, E2F1, IRAK1
46
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
7.8SPP1, TNF, TNFRSF1A, E2F1, IRAK1, STAT4

Compounds for genes affiliated with Pediatric Systemic Lupus Erythematosus

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46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 3BitterDB, 30IUPHAR, 25HMDB
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Compounds related to Pediatric Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1tab-1469.6IRAK1, TNFRSF1A, TNF
2mycophenolic acid46 52 1211.6VCAM1, SPP1, ICAM1
3txb2469.5APOH, IRAK1, C4A
4agarose469.5APOH, C4B, C4A, C3
5bcma469.5TNFSF13B, TNFRSF1A, TNF
6blys469.5TNFRSF1A, TNF, TNFSF13B
7lipoteichoic acid469.5APOH, TNF, IRAK1
8cuprophan469.4TNFRSF1A, VCAM1, ICAM1
9infliximab46 52 1211.3APOH, TNFRSF1A, TNF, SPP1
10apocynin46 6210.2VCAM1, TNF, ICAM1
11polymyxin b469.2VCAM1, TNF, ICAM1
12groalpha469.1VCAM1, TNF, ICAM1
13budesonide46 52 1211.1TNF, VCAM1, ICAM1
14etanercept46 52 1211.1APOH, TNFRSF1A, TNF
15parthenolide46 310.1ICAM1, VCAM1, TNF
168-isoprostane469.0APOH, VCAM1, ICAM1, TNF
17troglitazone46 30 62 1212.0ICAM1, SPP1, TNF, VCAM1
18neopterin468.9TNF, C3, TNFRSF1A, ICAM1
19creatinine468.9C3, APOH, TNFRSF1A, TNFSF13B, SPP1
20okt3468.9TNFRSF1A, VCAM1, ICAM1, TNF
21sp 60012546 629.8TNF, ICAM1, VCAM1, TNFRSF1A
22simvastatin46 52 62 30 25 1213.8TNFRSF1A, TNF, ICAM1, VCAM1
23heparin46 30 25 1211.7C4B, C3, VCAM1, TNFRSF1A, SPP1, APOH
24genistein46 30 62 3 25 1213.7SPP1, VCAM1, ICAM1, IRAK1, TNF
25fmlp468.7TNFRSF1A, ICAM1, TNF, VCAM1
26tgf beta1468.6TNFRSF1A, SPP1, VCAM1, E2F1, TNF
27herbimycin a46 629.6VCAM1, TNFRSF1A, TNF, SPP1, ICAM1
28curcumin468.6TNF, VCAM1, TNFRSF1A, SPP1, ICAM1
29superoxide46 259.6APOH, TNFRSF1A, VCAM1, TNF, SPP1
30rantes468.6VCAM1, TNFRSF1A, TNF, IRAK1, ICAM1
31methotrexate52 46 1210.6APOH, TNFRSF1A, TNF, E2F1
32sb 20358046 629.6VCAM1, ICAM1, TNFRSF1A, TNF, SPP1
33prostacyclin468.6ICAM1, TNF, TNFRSF1A, APOH, VCAM1
34alanine468.5IRAK1, VCAM1, TNFRSF1A, TNFSF13B, SPP1, E2F1
35actinomycin d468.5TNFRSF1A, E2F1, TNF, SPP1, ICAM1
36pge2468.5VCAM1, TNFRSF1A, SPP1, ICAM1, TNF
37fibrinogen468.4APOH, C3, ICAM1, VCAM1, SPP1, TNF
38lactate468.3SPP1, TNF, APOH, VCAM1, ICAM1, C3
39estrogen468.2TNFRSF1A, SPP1, C3, VCAM1, E2F1, APOH
40endotoxin468.1C4A, VCAM1, APOH, ICAM1, TNFRSF1A, TNF
41dexamethasone46 52 30 1211.0VCAM1, TNF, SPP1, STAT4, C3, ICAM1
42tyrosine467.9STAT4, IRAK1, SPP1, TNFRSF1A, E2F1, VCAM1
43cycloheximide467.8TNF, SPP1, TNFRSF1A, ICAM1, E2F1
44nitric oxide46 25 129.8TNFRSF1A, TNF, APOH, E2F1, VCAM1, ICAM1
45vegf467.8APOH, ICAM1, VCAM1, TNFRSF1A, TNF, SPP1
46retinoic acid46 258.7E2F1, TNFRSF1A, SPP1, VCAM1, TNF, ICAM1
47lipid467.7TNFRSF1A, TNF, SPP1, E2F1, APOH, VCAM1
48phosphatidylinositol467.6IRAK1, ICAM1, E2F1, STAT4, C3, APOH
49serine467.2TNF, C4B, C3, STAT4, IRAK1, VCAM1
50oxygen46 257.9TNF, TNFRSF1A, SPP1, APOH, C4A, E2F1

GO Terms for genes affiliated with Pediatric Systemic Lupus Erythematosus

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17Gene Ontology
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Cellular components related to Pediatric Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.2C4B, C4A, C3
2external side of plasma membraneGO:0098978.9ICAM1, VCAM1, TNF
3cell surfaceGO:0099868.6TNF, TNFRSF1A, APOH, VCAM1
4extracellular regionGO:0055768.2SPP1, TNF, TNFRSF1A, C3, C4A, C4B
5extracellular spaceGO:0056157.3C3, SPP1, TNFSF13B, TNF, TNFRSF1A, APOH
6plasma membraneGO:0058867.0TNFSF13B, TNF, TNFRSF1A, VCAM1, IRAK1, ICAM1

Biological processes related to Pediatric Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1regulation of complement activationGO:0304499.9C4B, C4A, C3
2complement activationGO:0069569.9C3, C4A, C4B
3complement activation, classical pathwayGO:0069589.9C4B, C4A, C3
4membrane to membrane dockingGO:0226149.8ICAM1, VCAM1
5response to amino acidGO:0432009.7ICAM1, TNFRSF1A
6lipopolysaccharide-mediated signaling pathwayGO:0316639.7IRAK1, TNF
7leukocyte tethering or rollingGO:0509019.7TNF, VCAM1
8response to lipopolysaccharideGO:0324969.6IRAK1, VCAM1, TNFRSF1A
9negative regulation of interleukin-6 productionGO:0327159.6TNF, TNFRSF1A
10leukocyte cell-cell adhesionGO:0071599.6ICAM1, VCAM1
11cellular response to glucose stimulusGO:0713339.5ICAM1, VCAM1
12cellular response to hypoxiaGO:0714569.5ICAM1, IRAK1, E2F1
13positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.4IRAK1, TNFRSF1A, TNF
14regulation of immune responseGO:0507769.4C3, ICAM1, VCAM1
15heterophilic cell-cell adhesionGO:0071579.4ICAM1, VCAM1
16response to ethanolGO:0454719.4TNFRSF1A, VCAM1, ICAM1
17positive regulation of nitric oxide biosynthetic processGO:0454299.3TNF, ICAM1
18positive regulation of NF-kappaB transcription factor activityGO:0510929.3TNF, IRAK1, ICAM1
19intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.3E2F1, TNFRSF1A, TNF
20cytokine-mediated signaling pathwayGO:0192219.2TNFRSF1A, VCAM1, ICAM1, STAT4
21response to hypoxiaGO:0016669.2VCAM1, TNFRSF1A, TNF
22innate immune responseGO:0450879.0C4B, C4A, C3, IRAK1
23extracellular matrix organizationGO:0301988.9SPP1, TNF, VCAM1, ICAM1
24positive regulation of transcription from RNA polymerase II promoterGO:0459448.8TNF, TNFRSF1A, E2F1, IRAK1, STAT4
25inflammatory responseGO:0069548.6C4B, SPP1, TNF, TNFRSF1A, C3, C4A

Molecular functions related to Pediatric Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:0048669.5C4B, C4A, C3
2tumor necrosis factor receptor bindingGO:0051649.2TNFSF13B, TNF
3cytokine activityGO:0051259.1TNF, TNFSF13B, SPP1
4protein bindingGO:0055156.9TNF, TNFRSF1A, PTPN22, APOH, E2F1, IRAK1

Products for genes affiliated with Pediatric Systemic Lupus Erythematosus

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Sources for Pediatric Systemic Lupus Erythematosus

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet