MCID: PDT027
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Pediatric Ulcerative Colitis malady

Rare diseases category

Summaries for Pediatric Ulcerative Colitis

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MalaCards based summary: Pediatric Ulcerative Colitis, also known as ulcerative colitis, pediatric, is related to ulcerative colitis and inflammatory bowel disease. An important gene associated with Pediatric Ulcerative Colitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are Matrix Metalloproteinases and Influenza A. The compounds pranlukast and groalpha have been mentioned in the context of this disorder. Affiliated tissues include colon and liver.

Aliases & Classifications for Pediatric Ulcerative Colitis

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Pediatric Ulcerative Colitis, Aliases & Descriptions:

Name: Pediatric Ulcerative Colitis 42 61
 
Ulcerative Colitis, Pediatric 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Pediatric Ulcerative Colitis

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Graphical network of the top 20 diseases related to Pediatric Ulcerative Colitis:



Diseases related to pediatric ulcerative colitis

Symptoms for Pediatric Ulcerative Colitis

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Drugs & Therapeutics for Pediatric Ulcerative Colitis

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Drug clinical trials:

Search ClinicalTrials for Pediatric Ulcerative Colitis

Search NIH Clinical Center for Pediatric Ulcerative Colitis

Genetic Tests for Pediatric Ulcerative Colitis

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Anatomical Context for Pediatric Ulcerative Colitis

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MalaCards organs/tissues related to Pediatric Ulcerative Colitis:

32
Colon, Liver

Animal Models for Pediatric Ulcerative Colitis or affiliated genes

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Publications for Pediatric Ulcerative Colitis

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Articles related to Pediatric Ulcerative Colitis:

(show top 50)    (show all 63)
idTitleAuthorsYear
1
Taking Full Measure of the Pediatric Ulcerative Colitis Activity Index (PUCAI). (25373859)
2014
2
Clinical course of infliximab treatment in korean pediatric ulcerative colitis patients: a single center experience. (24749085)
2014
3
Feasibility and Validity of the Pediatric Ulcerative Colitis Activity Index in Routine Clinical Practice. (25221935)
2014
4
Differences in the management of pediatric and adult onset ulcerative colitis - lessons from the joint ECCO and ESPGHAN consensus guidelines for the management of pediatric ulcerative colitis. (24230969)
2014
5
Safe azathioprine treatment in a pediatric ulcerative colitis patient with TPMT*16 by thiopurine metabolite monitoring. (25036765)
2014
6
Fecal Microbial Transplant via Nasogastric Tube for Active Pediatric Ulcerative Colitis. (25162366)
2014
7
Combination of oral antibiotics may be effective in severe pediatric ulcerative colitis: A preliminary report. (24958064)
2014
8
Steps toward harmonization for clinical development of medicines in pediatric ulcerative colitis-a global scientific discussion, part 2: data extrapolation, trial design, and pharmacokinetics. (24866782)
2014
9
Second-generation colon capsule endoscopy vs. colonoscopy in pediatric ulcerative colitis: a pilot study. (24777427)
2014
10
Allopurinol: a useful adjunct to thiopurine therapy for pediatric ulcerative colitis in the biologic era. (24590210)
2014
11
Pediatric ulcerative colitis: a practical guide to management. (24723200)
2014
12
DNA methylation-associated colonic mucosal immune and defense responses in treatment-naA^ve pediatric ulcerative colitis. (24937444)
2014
13
Steps toward harmonization for clinical development of medicines in pediatric ulcerative colitis-a global scientific discussion, part 1: efficacy endpoints and disease outcome assessments. (24866781)
2014
14
Ultrasonography of the colon in pediatric ulcerative colitis: a prospective, blind, comparative study with colonoscopy. (24725581)
2014
15
Complementary, integrative, and holistic medicine: integrative approaches to pediatric ulcerative colitis. (24000344)
2013
16
Fecal calprotectin and clinical disease activity in pediatric ulcerative colitis. (23533791)
2013
17
Presenting features and disease course of pediatric ulcerative colitis. (23583691)
2013
18
Health-related quality of life in pediatric ulcerative colitis patients on conventional medical treatment compared to those after restorative proctocolectomy. (22914964)
2013
19
Pediatric Ulcerative Colitis: The Therapeutic Road to Infliximab. (24392300)
2013
20
History of and current issues affecting surgery for pediatric ulcerative colitis. (23203770)
2013
21
Interleukin-6 is associated with steroid resistance and reflects disease activity in severe pediatric ulcerative colitis. (23339932)
2013
22
Periappendiceal inflammation in pediatric ulcerative colitis. (23552766)
2013
23
Predictive value of the Pediatric Ulcerative Colitis Activity Index in the surgical management of ulcerative colitis. (23895969)
2013
24
Role of surgery in pediatric ulcerative colitis. (24173816)
2013
25
Matrix metalloproteinases in the restorative proctocolectomy pouch of pediatric ulcerative colitis. (22912554)
2012
26
Infliximab for the treatment of pediatric ulcerative colitis. (23237250)
2012
27
CRP and pediatric ulcerative colitis. (22325182)
2012
28
High-dose infliximab for treatment of pediatric ulcerative colitis: a survey of clinical practice. (22468086)
2012
29
Plasmablast frequency and trafficking receptor expression are altered in pediatric ulcerative colitis. (22488927)
2012
30
C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) or both? A systematic evaluation in pediatric ulcerative colitis. (21939916)
2011
31
Assessing disease risk in pediatric ulcerative colitis. (20629182)
2011
32
Cost-effectiveness analysis of adjunct VSL#3 therapy versus standard medical therapy in pediatric ulcerative colitis. (21694634)
2011
33
Mesalamine-induced myocarditis and coronary vasculitis in a pediatric ulcerative colitis patient: a case report. (22611512)
2011
34
Glucocorticoid bioactivity does not predict response to steroid therapy in severe pediatric ulcerative colitis. (19714760)
2010
35
Severe pediatric ulcerative colitis: a prospective multicenter study of outcomes and predictors of response. (20193683)
2010
36
Increased mucosal expression of GATA-3 and STAT-4 in pediatric ulcerative colitis. (20030749)
2010
37
Mathematical weighting of a clinimetric index (Pediatric Ulcerative Colitis Activity Index) was superior to the judgmental approach. (19124220)
2009
38
Severe chest pain in a pediatric ulcerative colitis patient after 5-aminosalicylic acid therapy. (18666333)
2008
39
Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis. (18981162)
2008
40
Mesalamine hypersensitivity and Kounis syndrome in a pediatric ulcerative colitis patient. (19084925)
2008
41
Short- and long-term response to and weaning from infliximab therapy in pediatric ulcerative colitis. (17325550)
2007
42
Development, validation, and evaluation of a pediatric ulcerative colitis activity index: a prospective multicenter study. (17681163)
2007
43
Infliximab efficacy in pediatric ulcerative colitis. (15735427)
2005
44
Infliximab in pediatric ulcerative colitis: two-year follow-up. (15076630)
2004
45
Infliximab as a novel therapy for pediatric ulcerative colitis. (11964959)
2002
46
Pediatric ulcerative colitis: a review of the disease and current therapy. (9697570)
1998
47
Surgery for pediatric ulcerative colitis. (7663621)
1995
48
Prolonged medical therapy for severe pediatric ulcerative colitis. (7733078)
1995
49
Liver disease in pediatric ulcerative colitis. (7884611)
1995
50
Proctocolectomy and quadruple-limb W pouch reconstruction for the management of pediatric ulcerative colitis and familial polyposis. (8014804)
1994

Variations for Pediatric Ulcerative Colitis

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Expression for genes affiliated with Pediatric Ulcerative Colitis

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Expression patterns in normal tissues for genes affiliated with Pediatric Ulcerative Colitis

Search GEO for disease gene expression data for Pediatric Ulcerative Colitis.

Pathways for genes affiliated with Pediatric Ulcerative Colitis

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Pathways related to Pediatric Ulcerative Colitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1PRSS1, TNF
2
Show member pathways
9.1PRSS1, TNF
3
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
9.0CCL11, TNF
4
Show member pathways
9.0CCL11, TNF

Compounds for genes affiliated with Pediatric Ulcerative Colitis

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Compounds related to Pediatric Ulcerative Colitis according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1pranlukast44 29 1211.4CCL11, TNF
2groalpha449.4CCL11, TNF
3budesonide44 50 1211.4CCL11, TNF
4fluticasone propionate44 50 60 1212.4CCL11, TNF
5rolipram44 60 2911.4TNF, CCL11
6poly(i-c)449.4CCL11, TNF
7tarc449.4CCL11, TNF
8peptidoglycan44 2910.4CCL11, TNF
9n-formylmethionyl-leucylphenylalanine449.4TNF, CCL11
10ccl344 2910.4CCL11, TNF
1115-deoxy-delta-12,14-prostaglandin j2449.4CCL11, TNF
12leukotriene b444 60 2511.4TNF, CCL11
13prednisolone44 29 1211.4CCL11, TNF
14troglitazone44 29 60 1212.4TNF, CCL11
15herbimycin a44 6010.4CCL11, TNF
16endotoxin449.4CCL11, TNF
17ionomycin449.4CCL11, TNF
18fmlp449.3TNF, CCL11
19prostaglandin449.3CCL11, TNF
20fibrinogen449.3TNF, PRSS1
21tacrolimus44 50 1211.3CCL11, TNF
22rantes449.3CCL11, TNF
23n acetylcysteine449.3TNF, CCL11
24indomethacin44 29 60 1212.3CCL11, TNF
25sb 20358044 6010.3CCL11, TNF
26butyrate449.3CCL11, TNF
27histamine44 29 2511.2CCL11, TNF
28ly294002449.2CCL11, TNF
29actinomycin d449.1CCL11, TNF
30genistein44 29 60 3 25 1214.1TNF, CCL11
31cyclosporin a44 29 6011.0CCL11, TNF
32thymidine44 2510.0CCL11, TNF
33pge2448.9CCL11, TNF
34superoxide44 259.7CCL11, TNF

GO Terms for genes affiliated with Pediatric Ulcerative Colitis

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Cellular components related to Pediatric Ulcerative Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5CCL11, PRSS1, TNF

Biological processes related to Pediatric Ulcerative Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:0301989.1PRSS1, TNF
2response to virusGO:0096158.9CCL11, TNF
3inflammatory responseGO:0069548.7CCL11, TNF

Products for genes affiliated with Pediatric Ulcerative Colitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Pediatric Ulcerative Colitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet