MCID: PDT027
MIFTS: 29

Pediatric Ulcerative Colitis malady

Categories: Rare diseases

Aliases & Classifications for Pediatric Ulcerative Colitis

Aliases & Descriptions for Pediatric Ulcerative Colitis:

Name: Pediatric Ulcerative Colitis 50 69
Ulcerative Colitis, Pediatric 50

Classifications:



Summaries for Pediatric Ulcerative Colitis

MalaCards based summary : Pediatric Ulcerative Colitis, also known as ulcerative colitis, pediatric, is related to ulcerative colitis and colitis. An important gene associated with Pediatric Ulcerative Colitis is CXCL5 (C-X-C Motif Chemokine Ligand 5), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and monocytes.

Related Diseases for Pediatric Ulcerative Colitis

Diseases related to Pediatric Ulcerative Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
id Related Disease Score Top Affiliating Genes
1 ulcerative colitis 10.6
2 colitis 10.6
3 mucositis 9.9
4 glycogen storage disease ix 9.8 CCL11 TPMT
5 inflammatory bowel disease 9.8
6 parkinson disease 11 9.7 CCL11 TPMT
7 wagr syndrome 9.6 CCL11 CXCL5 TPMT
8 liver disease 9.6
9 sclerosing cholangitis 9.6
10 purpura 9.6
11 myocarditis 9.6
12 vasculitis 9.6
13 cholangitis 9.6
14 pouchitis 9.6
15 pentalogy of cantrell 9.2 CCL11 CXCL5 MIR4284 PRSS1 TPMT

Graphical network of the top 20 diseases related to Pediatric Ulcerative Colitis:



Diseases related to Pediatric Ulcerative Colitis

Symptoms & Phenotypes for Pediatric Ulcerative Colitis

Drugs & Therapeutics for Pediatric Ulcerative Colitis

Drugs for Pediatric Ulcerative Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 90)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
3
Infliximab Approved Phase 4,Phase 3,Phase 1 170277-31-3
4
Prednisone Approved, Vet_approved Phase 4,Phase 3 53-03-2 5865
5
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
6
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
7
Metronidazole Approved Phase 4 443-48-1 4173
8
Nicotine Approved Phase 4 54-11-5 942 89594
9
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
10
Vancomycin Approved Phase 4 1404-90-6 441141 14969
11
Butyric Acid Experimental Phase 4 107-92-6 264
12 Analgesics Phase 4,Phase 3,Phase 1
13 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 1
14 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 1
15 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 1
16 Antirheumatic Agents Phase 4,Phase 3,Phase 1
17 Mesalamine Phase 4,Phase 3 89-57-6
18 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1
19 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
20 Immunosuppressive Agents Phase 4,Phase 3
21 Vaccines Phase 4
22 Anti-Bacterial Agents Phase 4,Phase 3
23 Anti-Infective Agents Phase 4,Phase 3
24 Antiemetics Phase 4
25 Antineoplastic Agents, Hormonal Phase 4
26 Autonomic Agents Phase 4
27 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
28 glucocorticoids Phase 4,Phase 2,Phase 3
29 Hormone Antagonists Phase 4
30 Hormones Phase 4
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
32 Methylprednisolone acetate Phase 4
33 Methylprednisolone Hemisuccinate Phase 4
34 Neuroprotective Agents Phase 4
35 Prednisolone acetate Phase 4
36 Prednisolone hemisuccinate Phase 4
37 Prednisolone phosphate Phase 4
38 Protective Agents Phase 4
39 Dermatologic Agents Phase 4,Phase 3
40 Antibiotics, Antitubercular Phase 4
41 Antiparasitic Agents Phase 4
42 Antiprotozoal Agents Phase 4
43 Antitubercular Agents Phase 4,Phase 3
44 Antimalarials Phase 4
45 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
46 Cytochrome P-450 Enzyme Inhibitors Phase 4
47 Gentamicins Phase 4
48 Topoisomerase Inhibitors Phase 4
49
Alendronate Approved Phase 2, Phase 3 121268-17-5, 66376-36-1 2088
50
Adalimumab Approved Phase 3 331731-18-1 16219006

Interventional clinical trials:

(show top 50) (show all 90)
id Name Status NCT ID Phase
1 A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Unknown status NCT01632462 Phase 4
2 Once Versus Twice Daily Mesalamine to Induce Remission in Pediatric Ulcerative Colitis Completed NCT01201122 Phase 4
3 Induction of Immunity Against Streptococcus Pneumoniae in Adults With Inflammatory Bowel Disease Completed NCT01908283 Phase 4
4 Use of a Novel Diet (UC DIET) for Treatment of Mild to Moderate Active Pediatric Ulcerative Colitis Recruiting NCT02345733 Phase 4
5 Manipulating the Microbiome in IBD by Antibiotics and FMT Recruiting NCT02033408 Phase 4
6 An Efficacy and Safety Study of Infliximab in Pediatric Participants With Inflammatory Bowel Disease Recruiting NCT02566889 Phase 4
7 Predicting Response to Standardized Pediatric Colitis Therapy Active, not recruiting NCT01536535 Phase 4
8 Clinical Study of TA-650 in Pediatric Patients With Ulcerative Colitis Completed NCT01585155 Phase 3
9 A Study of the Safety and Efficacy of Infliximab(REMICADE ) in Pediatric Patients With Moderately to SeverelyActive Ulcerative Colitis Completed NCT00336492 Phase 3
10 Assessing the Safety/Efficacy of Asacol® Given Every 12 Hours to Children and Adolescents With Active Ulcerative Colitis Completed NCT00713310 Phase 3
11 Thalidomide in Pediatric Inflammatory Bowel Diseases. Completed NCT00720538 Phase 3
12 Alendronate Osteoporosis Study Completed NCT00277251 Phase 2, Phase 3
13 Efficacy and Safety of Adalimumab in Pediatric Subjects With Moderate to Severe Ulcerative Colitis Recruiting NCT02065557 Phase 3
14 Safety and Efficacy of MMX Mesalamine/Mesalazine in Pediatric Subjects With Mild to Moderate Ulcerative Colitis Recruiting NCT02093663 Phase 3
15 Study for Participants With Ulcerative Colitis Previously Enrolled in Etrolizumab Phase II/III Studies Recruiting NCT02118584 Phase 3
16 A Study of the Efficacy and Safety of Etrolizumab Treatment in Maintenance of Disease Remission in Ulcerative Colitis Participants Who Are Naive to Tumor Necrosis Factor (TNF) Inhibitors Recruiting NCT02165215 Phase 3
17 A Study of the Efficacy and Safety of Etrolizumab in Ulcerative Colitis Participants Who Are Refractory to or Intolerant of Tumor Necrosis Factor (TNF) Inhibitors Recruiting NCT02100696 Phase 3
18 Improving Medication Adherence in Pediatric Inflammatory Bowel Disease Active, not recruiting NCT01536509 Phase 3
19 Long-term Safety and Efficacy Study of Adalimumab in Pediatric Subjects With Ulcerative Colitis Enrolling by invitation NCT02632175 Phase 3
20 Curcumin in Pediatric Ulcerative Colitis Not yet recruiting NCT02277223 Phase 3
21 Assessing the Safety/Efficacy of Asacol® Given Every 12 Hours to Children and Adolescents for the Maintenance of Remission of Ulcerative Colitis Terminated NCT01004185 Phase 3
22 Weekly Vitamin D in Pediatric IBD Completed NCT02076750 Phase 1, Phase 2
23 Efficacy and Safety of GLPG1205 in Subjects With Active Ulcerative Colitis Completed NCT02337608 Phase 2
24 Efficacy and Safety of GLPG0634 in Subjects With Active Crohn's Disease Completed NCT02048618 Phase 2
25 Fecal Microbiota Transplant (FMT) in Pediatric Active Ulcerative Colitis Recruiting NCT02330653 Phase 1, Phase 2
26 Efficacy and Safety Study of GED-0507-34-Levo for Treatment of UC Recruiting NCT02808390 Phase 2
27 Vedolizumab IV in Pediatric Participants With Ulcerative Colitis or Crohn's Disease Not yet recruiting NCT03138655 Phase 2
28 Clotrimazole Enemas for Pouchitis in Children and Adults Suspended NCT00061282 Phase 1, Phase 2
29 Lactobacillus GG in Pediatric Ulcerative Colitis (UC) Withdrawn NCT00895336 Phase 2
30 Fecal Microbiota Transplantation (FMT) for Treatment of Ulcerative Colitis in Children Completed NCT01947101 Phase 1
31 Bacteriotherapy in Pediatric Inflammatory Bowel Disease Completed NCT01757964 Phase 1
32 Gut Microbial Transplantation in Pediatric Inflammatory Bowel Diseases Completed NCT01560819 Phase 1
33 Curcumin in Pediatric Inflammatory Bowel Disease Completed NCT00889161 Phase 1
34 Evaluation of Urinary Isoprostanes in the Assessment of Children With Inflammatory Bowel Disease Completed NCT00215020 Phase 1
35 Protein and Energy Metabolism in Pediatric Crohn's Disease Completed NCT00583232 Phase 1
36 Pediatric FEcal Microbial Transplant for Ulcerative Colitis Recruiting NCT02487238 Phase 1
37 Safety and Tolerability Of Allogeneic Mesenchymal Stromal Cells in Pediatric Inflammatory Bowel Disease Recruiting NCT02150551 Phase 1
38 Fecal Microbiota Transplantation in Pediatric Patients Active, not recruiting NCT02108821 Phase 1
39 A Study to Assess the Safety and Pharmacokinetics of Subcutaneously Administered Golimumab, a Human Anti-TNFα Antibody, in Pediatric Patients With Moderate to Severe Active Ulcerative Colitis Active, not recruiting NCT01900574 Phase 1
40 Validating NIAAA Screen Guide in YCMC Unknown status NCT01544218
41 Influence of Aerobic Exercise Training (AET) on Inflammatory Bowel Disease (IBD) in Children and Adolescents Unknown status NCT02264275
42 Safety of Anti-tumor Necrosis Factor (TNF) Monoclonal Antibodies in Inflammatory Bowel Disease Unknown status NCT02066272
43 Evaluation Of The Pillcam™ Colon Capsule Endoscopy (Pcce-2) In Pediatric Ulcerative Colitis Completed NCT01740349
44 Efficacy of Infliximab as a Rescue Therapy in Pediatric Acute Severe Colitis Completed NCT02170714
45 Protein Metabolism in Newly Diagnosed Pediatric Inflammatory Bowel Disease Completed NCT00586352
46 ADAPT Adacolumn Pediatric Trial in Ulcerative Colitis Completed NCT00781638
47 Effects of Exclusive Enteral Nutrition on the Microbiome in Pediatric Inflammatory Bowel Disease Completed NCT02521064
48 Quality of Life in Pediatric Inflammatory Bowel Disease Completed NCT00061737
49 Infectious Agents in Pediatric Crohn's Completed NCT00237055
50 Understanding and Treating Neuropsychiatric Symptoms of Pediatric Physical Illness Completed NCT00769353

Search NIH Clinical Center for Pediatric Ulcerative Colitis

Genetic Tests for Pediatric Ulcerative Colitis

Anatomical Context for Pediatric Ulcerative Colitis

MalaCards organs/tissues related to Pediatric Ulcerative Colitis:

39
Colon, Testes, Monocytes, Liver

Publications for Pediatric Ulcerative Colitis

Articles related to Pediatric Ulcerative Colitis:

(show top 50) (show all 88)
id Title Authors Year
1
Prostaglandin E-major Urinary Metabolite as a Biomarker for Pediatric Ulcerative Colitis Activity. ( 27906804 )
2016
2
Genetics and Therapeutics in Pediatric Ulcerative Colitis: the Past, Present and Future. ( 26973787 )
2016
3
Randomized clinical trial: pharmacokinetics and safety of multimatrix mesalamine for treatment of pediatric ulcerative colitis. ( 26893546 )
2016
4
Colectomy in pediatric ulcerative colitis: A single center experience of indications, outcomes, and complications. ( 26653944 )
2016
5
Seeing without Looking: Predicting Mucosal Healing without Endoscopic Evaluation in Pediatric Ulcerative Colitis. ( 28045775 )
2016
6
Pouchitis in Pediatric Ulcerative Colitis Patients After Ileal Pouch Anal Anastomosis. ( 27602702 )
2016
7
The association of autoimmune diseases with pediatric ulcerative colitis does not influence its disease course. ( 26152794 )
2016
8
Efficacy and safety of granulocyte, monocyte/macrophage adsorptive in pediatric ulcerative colitis. ( 27158208 )
2016
9
Assessment of disease activity in pediatric ulcerative colitis. ( 27145213 )
2016
10
Effect of Early Versus Late Azathioprine Therapy in Pediatric Ulcerative Colitis. ( 27271489 )
2016
11
Item Generation and Reduction Towards Developing a Patient Reported Outcome for Pediatric Ulcerative Colitis (TUMMY-UC). ( 27159210 )
2016
12
Capillary Flow Rates in the Duodenum of Pediatric Ulcerative Colitis Patients are Increased and Unrelated to Inflammation. ( 28045777 )
2016
13
Difference between early onset and late onset pediatric ulcerative colitis. ( 26833925 )
2016
14
Characteristics of pediatric ulcerative colitis in Saudi Arabia: a multicenter national study. ( 26142933 )
2015
15
Pediatric ulcerative colitis surgery: Italian survey. ( 25895877 )
2015
16
A MicroRNA Signature in Pediatric Ulcerative Colitis: Deregulation of the miR-4284/CXCL5 Pathway in the Intestinal Epithelium. ( 25738378 )
2015
17
P631. Mesalamine versus azathioprine for maintenance treatment after steroid-induced remission in pediatric ulcerative colitis. ( 25718133 )
2015
18
Serum Cytokine Profiling of Leukocytapheresis in Pediatric Ulcerative Colitis. ( 25807968 )
2015
19
A Methodological Approach to Fecal Microbial Transplant via Nasogastric Tube for Active Pediatric Ulcerative Colitis. ( 25822774 )
2015
20
Thalidomide Treatment of Pediatric Ulcerative Colitis: A New Use for an Old Drug. ( 26199988 )
2015
21
Reply to Thalidomide Treatment of Pediatric Ulcerative Colitis: A New Use for an Old Drug. ( 25993695 )
2015
22
The Increased Expression of CCL20 and CCR6 in Rectal Mucosa Correlated to Severe Inflammation in Pediatric Ulcerative Colitis. ( 25691899 )
2015
23
Precolectomy Therapy Does Not Alter Histologic Findings Distribution in Resected Colon in Pediatric Ulcerative Colitis. ( 26465789 )
2015
24
Diagnostic Yield of Routine Enteropathogenic Stool Tests in Pediatric Ulcerative Colitis. ( 26663793 )
2015
25
Serial fecal microbiota transplantation alters mucosal gene expression in pediatric ulcerative colitis. ( 25853207 )
2015
26
Steps toward harmonization for clinical development of medicines in pediatric ulcerative colitis-a global scientific discussion, part 2: data extrapolation, trial design, and pharmacokinetics. ( 24866782 )
2014
27
Steps toward harmonization for clinical development of medicines in pediatric ulcerative colitis-a global scientific discussion, part 1: efficacy endpoints and disease outcome assessments. ( 24866781 )
2014
28
Clinical course of infliximab treatment in korean pediatric ulcerative colitis patients: a single center experience. ( 24749085 )
2014
29
Ultrasonography of the colon in pediatric ulcerative colitis: a prospective, blind, comparative study with colonoscopy. ( 24725581 )
2014
30
Alternate endpoints and clinical outcome assessments in pediatric ulcerative colitis registration trials. ( 24121142 )
2014
31
Allopurinol: a useful adjunct to thiopurine therapy for pediatric ulcerative colitis in the biologic era. ( 24590210 )
2014
32
Taking Full Measure of the Pediatric Ulcerative Colitis Activity Index (PUCAI). ( 25373859 )
2014
33
Fecal Microbial Transplant via Nasogastric Tube for Active Pediatric Ulcerative Colitis. ( 25162366 )
2014
34
Feasibility and Validity of the Pediatric Ulcerative Colitis Activity Index in Routine Clinical Practice. ( 25221935 )
2014
35
DNA methylation-associated colonic mucosal immune and defense responses in treatment-naA^ve pediatric ulcerative colitis. ( 24937444 )
2014
36
Pediatric ulcerative colitis: a practical guide to management. ( 24723200 )
2014
37
Safe azathioprine treatment in a pediatric ulcerative colitis patient with TPMT*16 by thiopurine metabolite monitoring. ( 25036765 )
2014
38
Differences in the management of pediatric and adult onset ulcerative colitis - lessons from the joint ECCO and ESPGHAN consensus guidelines for the management of pediatric ulcerative colitis. ( 24230969 )
2014
39
Second-generation colon capsule endoscopy vs. colonoscopy in pediatric ulcerative colitis: a pilot study. ( 24777427 )
2014
40
Combination of oral antibiotics may be effective in severe pediatric ulcerative colitis: A preliminary report. ( 24958064 )
2014
41
Fecal calprotectin and clinical disease activity in pediatric ulcerative colitis. ( 23533791 )
2013
42
Pediatric Ulcerative Colitis: The Therapeutic Road to Infliximab. ( 24392300 )
2013
43
Complementary, integrative, and holistic medicine: integrative approaches to pediatric ulcerative colitis. ( 24000344 )
2013
44
Duration of Disease May Predict Response to Infliximab in Pediatric Ulcerative Colitis. ( 24129407 )
2013
45
Low trypsinogen-1 expression in pediatric ulcerative colitis patients who undergo surgery. ( 23745029 )
2013
46
Interleukin-6 is associated with steroid resistance and reflects disease activity in severe pediatric ulcerative colitis. ( 23339932 )
2013
47
Atypical disease phenotypes in pediatric ulcerative colitis: 5-year analyses of the EUROKIDS Registry. ( 22570259 )
2013
48
History of and current issues affecting surgery for pediatric ulcerative colitis. ( 23203770 )
2013
49
Predictive value of the Pediatric Ulcerative Colitis Activity Index in the surgical management of ulcerative colitis. ( 23895969 )
2013
50
Role of surgery in pediatric ulcerative colitis. ( 24173816 )
2013

Variations for Pediatric Ulcerative Colitis

Expression for Pediatric Ulcerative Colitis

Search GEO for disease gene expression data for Pediatric Ulcerative Colitis.

Pathways for Pediatric Ulcerative Colitis

Pathways related to Pediatric Ulcerative Colitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.49 CCL11 CXCL5
2
Show member pathways
10.71 CCL11 CXCL5
3 10.19 CCL11 CXCL5

GO Terms for Pediatric Ulcerative Colitis

Biological processes related to Pediatric Ulcerative Colitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chemotaxis GO:0006935 8.96 CCL11 CXCL5
2 chemokine-mediated signaling pathway GO:0070098 8.62 CCL11 CXCL5

Molecular functions related to Pediatric Ulcerative Colitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.96 CCL11 CXCL5
2 chemokine activity GO:0008009 8.62 CCL11 CXCL5

Sources for Pediatric Ulcerative Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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