MCID: PDT027
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Pediatric Ulcerative Colitis malady

Rare diseases category

Summaries for Pediatric Ulcerative Colitis

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MalaCards based summary: Pediatric Ulcerative Colitis, also known as ulcerative colitis, pediatric, is related to ulcerative colitis and inflammatory bowel disease. An important gene associated with Pediatric Ulcerative Colitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are Matrix Metalloproteinases and Influenza A. The compounds pranlukast and groalpha have been mentioned in the context of this disorder. Affiliated tissues include colon and liver.

Aliases & Classifications for Pediatric Ulcerative Colitis

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Pediatric Ulcerative Colitis, Aliases & Descriptions:

Name: Pediatric Ulcerative Colitis 41 60
 
Ulcerative Colitis, Pediatric 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Pediatric Ulcerative Colitis

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Graphical network of the top 20 diseases related to Pediatric Ulcerative Colitis:



Diseases related to pediatric ulcerative colitis

Symptoms for Pediatric Ulcerative Colitis

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Drugs & Therapeutics for Pediatric Ulcerative Colitis

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Drug clinical trials:

Search ClinicalTrials for Pediatric Ulcerative Colitis

Search NIH Clinical Center for Pediatric Ulcerative Colitis

Genetic Tests for Pediatric Ulcerative Colitis

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Anatomical Context for Pediatric Ulcerative Colitis

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MalaCards organs/tissues related to Pediatric Ulcerative Colitis:

31
Colon, Liver

Animal Models for Pediatric Ulcerative Colitis or affiliated genes

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Publications for Pediatric Ulcerative Colitis

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Articles related to Pediatric Ulcerative Colitis:

(show top 50)    (show all 68)
idTitleAuthorsYear
1
Serial fecal microbiota transplantation alters mucosal gene expression in pediatric ulcerative colitis. (25853207)
2015
2
Pediatric ulcerative colitis surgery: Italian survey. (25895877)
2015
3
P631. Mesalamine versus azathioprine for maintenance treatment after steroid-induced remission in pediatric ulcerative colitis. (25718133)
2015
4
A Methodological Approach to Fecal Microbial Transplant via Nasogastric Tube for Active Pediatric Ulcerative Colitis. (25822774)
2015
5
Taking Full Measure of the Pediatric Ulcerative Colitis Activity Index (PUCAI). (25373859)
2014
6
Clinical course of infliximab treatment in korean pediatric ulcerative colitis patients: a single center experience. (24749085)
2014
7
Differences in the management of pediatric and adult onset ulcerative colitis - lessons from the joint ECCO and ESPGHAN consensus guidelines for the management of pediatric ulcerative colitis. (24230969)
2014
8
Safe azathioprine treatment in a pediatric ulcerative colitis patient with TPMT*16 by thiopurine metabolite monitoring. (25036765)
2014
9
Fecal Microbial Transplant via Nasogastric Tube for Active Pediatric Ulcerative Colitis. (25162366)
2014
10
Combination of oral antibiotics may be effective in severe pediatric ulcerative colitis: A preliminary report. (24958064)
2014
11
Steps toward harmonization for clinical development of medicines in pediatric ulcerative colitis-a global scientific discussion, part 2: data extrapolation, trial design, and pharmacokinetics. (24866782)
2014
12
Second-generation colon capsule endoscopy vs. colonoscopy in pediatric ulcerative colitis: a pilot study. (24777427)
2014
13
Allopurinol: a useful adjunct to thiopurine therapy for pediatric ulcerative colitis in the biologic era. (24590210)
2014
14
Pediatric ulcerative colitis: a practical guide to management. (24723200)
2014
15
DNA methylation-associated colonic mucosal immune and defense responses in treatment-naA^ve pediatric ulcerative colitis. (24937444)
2014
16
Steps toward harmonization for clinical development of medicines in pediatric ulcerative colitis-a global scientific discussion, part 1: efficacy endpoints and disease outcome assessments. (24866781)
2014
17
Complementary, integrative, and holistic medicine: integrative approaches to pediatric ulcerative colitis. (24000344)
2013
18
Fecal calprotectin and clinical disease activity in pediatric ulcerative colitis. (23533791)
2013
19
Presenting features and disease course of pediatric ulcerative colitis. (23583691)
2013
20
Health-related quality of life in pediatric ulcerative colitis patients on conventional medical treatment compared to those after restorative proctocolectomy. (22914964)
2013
21
Pediatric Ulcerative Colitis: The Therapeutic Road to Infliximab. (24392300)
2013
22
History of and current issues affecting surgery for pediatric ulcerative colitis. (23203770)
2013
23
Interleukin-6 is associated with steroid resistance and reflects disease activity in severe pediatric ulcerative colitis. (23339932)
2013
24
Periappendiceal inflammation in pediatric ulcerative colitis. (23552766)
2013
25
Predictive value of the Pediatric Ulcerative Colitis Activity Index in the surgical management of ulcerative colitis. (23895969)
2013
26
Matrix metalloproteinases in the restorative proctocolectomy pouch of pediatric ulcerative colitis. (22912554)
2012
27
Infliximab for the treatment of pediatric ulcerative colitis. (23237250)
2012
28
CRP and pediatric ulcerative colitis. (22325182)
2012
29
High-dose infliximab for treatment of pediatric ulcerative colitis: a survey of clinical practice. (22468086)
2012
30
Plasmablast frequency and trafficking receptor expression are altered in pediatric ulcerative colitis. (22488927)
2012
31
C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) or both? A systematic evaluation in pediatric ulcerative colitis. (21939916)
2011
32
Assessing disease risk in pediatric ulcerative colitis. (20629182)
2011
33
Cost-effectiveness analysis of adjunct VSL#3 therapy versus standard medical therapy in pediatric ulcerative colitis. (21694634)
2011
34
Mesalamine-induced myocarditis and coronary vasculitis in a pediatric ulcerative colitis patient: a case report. (22611512)
2011
35
Glucocorticoid bioactivity does not predict response to steroid therapy in severe pediatric ulcerative colitis. (19714760)
2010
36
Severe pediatric ulcerative colitis: a prospective multicenter study of outcomes and predictors of response. (20193683)
2010
37
Increased mucosal expression of GATA-3 and STAT-4 in pediatric ulcerative colitis. (20030749)
2010
38
Mathematical weighting of a clinimetric index (Pediatric Ulcerative Colitis Activity Index) was superior to the judgmental approach. (19124220)
2009
39
Severe chest pain in a pediatric ulcerative colitis patient after 5-aminosalicylic acid therapy. (18666333)
2008
40
Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis. (18981162)
2008
41
Short- and long-term response to and weaning from infliximab therapy in pediatric ulcerative colitis. (17325550)
2007
42
Development, validation, and evaluation of a pediatric ulcerative colitis activity index: a prospective multicenter study. (17681163)
2007
43
Infliximab efficacy in pediatric ulcerative colitis. (15735427)
2005
44
Infliximab in pediatric ulcerative colitis: two-year follow-up. (15076630)
2004
45
Infliximab as a novel therapy for pediatric ulcerative colitis. (11964959)
2002
46
Pediatric ulcerative colitis: a review of the disease and current therapy. (9697570)
1998
47
Surgery for pediatric ulcerative colitis. (7663621)
1995
48
Prolonged medical therapy for severe pediatric ulcerative colitis. (7733078)
1995
49
Liver disease in pediatric ulcerative colitis. (7884611)
1995
50
Proctocolectomy and quadruple-limb W pouch reconstruction for the management of pediatric ulcerative colitis and familial polyposis. (8014804)
1994

Variations for Pediatric Ulcerative Colitis

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Expression for genes affiliated with Pediatric Ulcerative Colitis

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Search GEO for disease gene expression data for Pediatric Ulcerative Colitis.

Pathways for genes affiliated with Pediatric Ulcerative Colitis

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Pathways related to Pediatric Ulcerative Colitis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1PRSS1, TNF
2
Show member pathways
9.1PRSS1, TNF
3
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.0CCL11, TNF
4
Show member pathways
9.0CCL11, TNF

Compounds for genes affiliated with Pediatric Ulcerative Colitis

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Compounds related to Pediatric Ulcerative Colitis according to GeneCards Suite gene sharing:

(show all 34)
idCompoundScoreTop Affiliating Genes
1pranlukast43 28 1211.4CCL11, TNF
2groalpha439.4CCL11, TNF
3budesonide43 49 1211.4CCL11, TNF
4fluticasone propionate43 49 59 1212.4CCL11, TNF
5rolipram43 59 2811.4TNF, CCL11
6poly(i-c)439.4CCL11, TNF
7tarc439.4CCL11, TNF
8peptidoglycan43 2810.4CCL11, TNF
9n-formylmethionyl-leucylphenylalanine439.4TNF, CCL11
10ccl343 2810.4CCL11, TNF
1115-deoxy-delta-12,14-prostaglandin j2439.4CCL11, TNF
12leukotriene b443 59 2411.4TNF, CCL11
13prednisolone43 28 1211.4CCL11, TNF
14troglitazone43 28 59 1212.4TNF, CCL11
15herbimycin a43 5910.4CCL11, TNF
16endotoxin439.4CCL11, TNF
17ionomycin439.4CCL11, TNF
18fmlp439.3TNF, CCL11
19prostaglandin439.3CCL11, TNF
20fibrinogen439.3TNF, PRSS1
21tacrolimus43 49 1211.3CCL11, TNF
22rantes439.3CCL11, TNF
23n acetylcysteine439.3TNF, CCL11
24indomethacin43 28 59 1212.3CCL11, TNF
25sb 20358043 5910.3CCL11, TNF
26butyrate439.3CCL11, TNF
27histamine43 28 2411.2CCL11, TNF
28ly294002439.2CCL11, TNF
29actinomycin d439.1CCL11, TNF
30genistein43 28 59 2 24 1214.1TNF, CCL11
31cyclosporin a43 28 5911.0CCL11, TNF
32thymidine43 2410.0CCL11, TNF
33pge2438.9CCL11, TNF
34superoxide43 249.7CCL11, TNF

GO Terms for genes affiliated with Pediatric Ulcerative Colitis

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Cellular components related to Pediatric Ulcerative Colitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.5CCL11, PRSS1, TNF

Biological processes related to Pediatric Ulcerative Colitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:00301989.1PRSS1, TNF
2response to virusGO:00096158.9CCL11, TNF
3inflammatory responseGO:00069548.7CCL11, TNF

Products for genes affiliated with Pediatric Ulcerative Colitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Pediatric Ulcerative Colitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet