MCID: PDT027
MIFTS: 24

Pediatric Ulcerative Colitis malady

Summaries for Pediatric Ulcerative Colitis

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33MalaCards
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MalaCards: Pediatric Ulcerative Colitis, also known as ulcerative colitis, pediatric, is related to ulcerative colitis and sclerosing cholangitis. An important gene associated with Pediatric Ulcerative Colitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are Immune response Fc epsilon RI pathway and Allograft rejection. The compounds pranlukast and groalpha have been mentioned in the context of this disorder. Affiliated tissues include colon and liver.

Aliases & Classifications for Pediatric Ulcerative Colitis

Sources:
43NIH Rare Diseases, 61UMLS
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Aliases & Descriptions:

pediatric ulcerative colitis 43 61
ulcerative colitis, pediatric 43


Related Diseases for Pediatric Ulcerative Colitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Pediatric Ulcerative Colitis:



Diseases related to pediatric ulcerative colitis

Clinical Features for Pediatric Ulcerative Colitis

Drugs & Therapeutics for Pediatric Ulcerative Colitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Pediatric Ulcerative Colitis

Drug clinical trials:

Search ClinicalTrials for Pediatric Ulcerative Colitis

Search NIH Clinical Center for Pediatric Ulcerative Colitis

Search CenterWatch for Pediatric Ulcerative Colitis

Genetic Tests for Pediatric Ulcerative Colitis

Anatomical Context for Pediatric Ulcerative Colitis

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33MalaCards
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MalaCards organs/tissues related to Pediatric Ulcerative Colitis:

33
Colon, Liver

Animal Models for Pediatric Ulcerative Colitis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Pediatric Ulcerative Colitis

Sources:
51PubMed
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Articles related to Pediatric Ulcerative Colitis:

(show top 50)    (show all 62)
idTitleAuthorsYear
1
Oral tacrolimus for pediatric steroid-resistant ulcerative colitis. (23582736)
2014
2
Alternate endpoints and clinical outcome assessments in pediatric ulcerative colitis registration trials. (24121142)
2014
3
Fecal calprotectin and clinical disease activity in pediatric ulcerative colitis. (23533791)
2013
4
Contemporary outcomes for ulcerative colitis inpatients admitted to pediatric hospitals in the United Kingdom. (23624885)
2013
5
Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. (23426446)
2013
6
Presenting features and disease course of pediatric ulcerative colitis. (23583691)
2013
7
Health-related quality of life in pediatric ulcerative colitis patients on conventional medical treatment compared to those after restorative proctocolectomy. (22914964)
2013
8
Interleukin-17 immunity in pediatric Crohn disease and ulcerative colitis. (23974060)
2013
9
History of and current issues affecting surgery for pediatric ulcerative colitis. (23203770)
2013
10
Interleukin-6 is associated with steroid resistance and reflects disease activity in severe pediatric ulcerative colitis. (23339932)
2013
11
Periappendiceal inflammation in pediatric ulcerative colitis. (23552766)
2013
12
Predictive value of the Pediatric Ulcerative Colitis Activity Index in the surgical management of ulcerative colitis. (23895969)
2013
13
MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis. (23856509)
2013
14
Role of surgery in pediatric ulcerative colitis. (24173816)
2013
15
Atypical disease phenotypes in pediatric ulcerative colitis: 5-year analyses of the EUROKIDS Registry. (22570259)
2013
16
Low trypsinogen-1 expression in pediatric ulcerative colitis patients who undergo surgery. (23745029)
2013
17
The natural history of ulcerative colitis in a pediatric population: a follow-up population-based cohort study. (23825926)
2013
18
Pediatric ulcerative colitis associated with primary sclerosing cholangitis: a distinct form of inflammatory bowel disease? the clinical relevance of anti-lactoferrin antibodies. (23485910)
2013
19
Matrix metalloproteinases in the restorative proctocolectomy pouch of pediatric ulcerative colitis. (22912554)
2012
20
Infliximab for the treatment of pediatric ulcerative colitis. (23237250)
2012
21
CRP and pediatric ulcerative colitis. (22325182)
2012
22
High-dose infliximab for treatment of pediatric ulcerative colitis: a survey of clinical practice. (22468086)
2012
23
Plasmablast frequency and trafficking receptor expression are altered in pediatric ulcerative colitis. (22488927)
2012
24
Management of pediatric ulcerative colitis: joint ECCO and ESPGHAN evidence-based consensus guidelines. (22773060)
2012
25
Pediatric ulcerative colitis: current treatment approaches including role of infliximab. (22740771)
2012
26
Pediatric ulcerative colitis associated with autoimmune diseases: a distinct form of inflammatory bowel disease? (22238154)
2012
27
C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) or both? A systematic evaluation in pediatric ulcerative colitis. (21939916)
2011
28
Assessing disease risk in pediatric ulcerative colitis. (20629182)
2011
29
Mesalamine-induced myocarditis and coronary vasculitis in a pediatric ulcerative colitis patient: a case report. (22611512)
2011
30
Agreement between patient- and physician-completed Pediatric Ulcerative Colitis Activity Index scores. (21593644)
2011
31
Glucocorticoid bioactivity does not predict response to steroid therapy in severe pediatric ulcerative colitis. (19714760)
2010
32
Severe pediatric ulcerative colitis: a prospective multicenter study of outcomes and predictors of response. (20193683)
2010
33
Mathematical weighting of a clinimetric index (Pediatric Ulcerative Colitis Activity Index) was superior to the judgmental approach. (19124220)
2009
34
Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis. (18981162)
2008
35
Mesalamine hypersensitivity and Kounis syndrome in a pediatric ulcerative colitis patient. (19084925)
2008
36
Infliximab for pediatric ulcerative colitis: a retrospective Italian multicenter study. (18598998)
2008
37
Idiopathic thrombocytopenic purpura after colectomy for pediatric ulcerative colitis. (18344179)
2008
38
Short- and long-term response to and weaning from infliximab therapy in pediatric ulcerative colitis. (17325550)
2007
39
Development, validation, and evaluation of a pediatric ulcerative colitis activity index: a prospective multicenter study. (17681163)
2007
40
Cytokine tumor necrosis factor-alpha A promoter gene polymorphism at position -308 G-->A and pediatric inflammatory bowel disease: implications in ulcerative colitis and Crohn's disease. (16707968)
2006
41
Protein microarray analysis of disease activity in pediatric inflammatory bowel disease demonstrates elevated serum PLGF, IL-7, TGF-beta1, and IL-12p40 levels in Crohn's disease and ulcerative colitis patients in remission versus active disease. (15667502)
2005
42
Infliximab in pediatric ulcerative colitis: two-year follow-up. (15076630)
2004
43
Cytokines, chemokine receptors, and homing molecule distribution in the rectum and stomach of pediatric patients with ulcerative colitis. (12960653)
2003
44
Pediatric ulcerative colitis: a review of the disease and current therapy. (9697570)
1998
45
Ulcerative colitis presenting with bronchiolitis obliterans organizing pneumonia in a pediatric patient. (9362212)
1997
46
Surgery for pediatric ulcerative colitis. (7663621)
1995
47
Prolonged medical therapy for severe pediatric ulcerative colitis. (7733078)
1995
48
Liver disease in pediatric ulcerative colitis. (7884611)
1995
49
Proctocolectomy and quadruple-limb W pouch reconstruction for the management of pediatric ulcerative colitis and familial polyposis. (8014804)
1994
50
Interleukin-2 production in pediatric inflammatory bowel disease: evidence for dissimilar mononuclear cell function in Crohn's disease and ulcerative colitis. (8271122)
1993

Genetic Variations for Pediatric Ulcerative Colitis

Expression for genes affiliated with Pediatric Ulcerative Colitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pediatric Ulcerative Colitis

Search GEO for disease gene expression data for Pediatric Ulcerative Colitis.

Pathways for genes affiliated with Pediatric Ulcerative Colitis

Sources:
12EMD Millipore, 30KEGG, 52QIAGEN
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Compounds for genes affiliated with Pediatric Ulcerative Colitis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Pediatric Ulcerative Colitis according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1pranlukast45 29 1111.5TNF, CCL11
2groalpha459.5TNF, CCL11
3budesonide45 50 1111.5TNF, CCL11
4fluticasone propionate45 50 60 1112.5CCL11, TNF
5poly(i-c)459.5TNF, CCL11
6tarc459.5TNF, CCL11
7peptidoglycan45 2910.5TNF, CCL11
8n-formylmethionyl-leucylphenylalanine459.5CCL11, TNF
9ccl345 2910.5TNF, CCL11
1015-deoxy-delta-12,14-prostaglandin j2459.5TNF, CCL11
11leukotriene b445 60 2411.5TNF, CCL11
12prednisolone45 29 1111.5CCL11, TNF
13troglitazone45 29 60 1112.5TNF, CCL11
14herbimycin a45 6010.4TNF, CCL11
15ionomycin459.4TNF, CCL11
16fmlp459.4CCL11, TNF
17prostaglandin459.4TNF, CCL11
18rantes459.4TNF, CCL11
19n acetylcysteine459.4TNF, CCL11
20indomethacin45 60 29 1112.4CCL11, TNF
21sb 20358045 6010.4TNF, CCL11
22butyrate459.3TNF, CCL11
23histamine45 29 2411.3CCL11, TNF
24ly294002459.3TNF, CCL11
25actinomycin d459.2TNF, CCL11
26genistein45 29 60 2 11 2414.2TNF, CCL11
27cyclosporin a45 29 6011.1CCL11, TNF
28thymidine45 2410.1TNF, CCL11
29pge2459.0TNF, CCL11
30superoxide45 249.8TNF, CCL11

GO Terms for genes affiliated with Pediatric Ulcerative Colitis

Sources:
16Gene Ontology
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Biological processes related to Pediatric Ulcerative Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:0069549.1TNF, CCL11
2response to virusGO:0096158.8TNF, CCL11

Products for genes affiliated with Pediatric Ulcerative Colitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pediatric Ulcerative Colitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet