MCID: PDT027
MIFTS: 28

Pediatric Ulcerative Colitis malady

Rare diseases category
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Summaries for Pediatric Ulcerative Colitis

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33MalaCards
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MalaCards: Pediatric Ulcerative Colitis, also known as ulcerative colitis, pediatric, is related to ulcerative colitis and inflammatory bowel disease. An important gene associated with Pediatric Ulcerative Colitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are Matrix Metalloproteinases and Influenza A. The compounds pranlukast and groalpha have been mentioned in the context of this disorder. Affiliated tissues include liver.

Aliases & Classifications for Pediatric Ulcerative Colitis

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43NIH Rare Diseases, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

pediatric ulcerative colitis 43 62
ulcerative colitis, pediatric 43


Related Diseases for Pediatric Ulcerative Colitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Pediatric Ulcerative Colitis:



Diseases related to pediatric ulcerative colitis

Symptoms for Pediatric Ulcerative Colitis

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Drugs & Therapeutics for Pediatric Ulcerative Colitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Pediatric Ulcerative Colitis

Search NIH Clinical Center for Pediatric Ulcerative Colitis

Genetic Tests for Pediatric Ulcerative Colitis

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Anatomical Context for Pediatric Ulcerative Colitis

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33MalaCards
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MalaCards organs/tissues related to Pediatric Ulcerative Colitis:

33
Liver

Animal Models for Pediatric Ulcerative Colitis or affiliated genes

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Publications for Pediatric Ulcerative Colitis

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52PubMed
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Articles related to Pediatric Ulcerative Colitis:

(show all 48)
idTitleAuthorsYear
1
Differences in the management of pediatric and adult onset ulcerative colitis - lessons from the joint ECCO and ESPGHAN consensus guidelines for the management of pediatric ulcerative colitis. (24230969)
2014
2
Alternate endpoints and clinical outcome assessments in pediatric ulcerative colitis registration trials. (24121142)
2014
3
Fecal calprotectin and clinical disease activity in pediatric ulcerative colitis. (23533791)
2013
4
Presenting features and disease course of pediatric ulcerative colitis. (23583691)
2013
5
Health-related quality of life in pediatric ulcerative colitis patients on conventional medical treatment compared to those after restorative proctocolectomy. (22914964)
2013
6
Pediatric Ulcerative Colitis: The Therapeutic Road to Infliximab. (24392300)
2013
7
History of and current issues affecting surgery for pediatric ulcerative colitis. (23203770)
2013
8
Interleukin-6 is associated with steroid resistance and reflects disease activity in severe pediatric ulcerative colitis. (23339932)
2013
9
Periappendiceal inflammation in pediatric ulcerative colitis. (23552766)
2013
10
Predictive value of the Pediatric Ulcerative Colitis Activity Index in the surgical management of ulcerative colitis. (23895969)
2013
11
Role of surgery in pediatric ulcerative colitis. (24173816)
2013
12
Atypical disease phenotypes in pediatric ulcerative colitis: 5-year analyses of the EUROKIDS Registry. (22570259)
2013
13
Duration of Disease May Predict Response to Infliximab in Pediatric Ulcerative Colitis. (24129407)
2013
14
Low trypsinogen-1 expression in pediatric ulcerative colitis patients who undergo surgery. (23745029)
2013
15
Pediatric ulcerative colitis associated with primary sclerosing cholangitis: a distinct form of inflammatory bowel disease? the clinical relevance of anti-lactoferrin antibodies. (23485910)
2013
16
Matrix metalloproteinases in the restorative proctocolectomy pouch of pediatric ulcerative colitis. (22912554)
2012
17
Infliximab for the treatment of pediatric ulcerative colitis. (23237250)
2012
18
CRP and pediatric ulcerative colitis. (22325182)
2012
19
High-dose infliximab for treatment of pediatric ulcerative colitis: a survey of clinical practice. (22468086)
2012
20
Plasmablast frequency and trafficking receptor expression are altered in pediatric ulcerative colitis. (22488927)
2012
21
Management of pediatric ulcerative colitis: joint ECCO and ESPGHAN evidence-based consensus guidelines. (22773060)
2012
22
Pediatric ulcerative colitis: current treatment approaches including role of infliximab. (22740771)
2012
23
C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) or both? A systematic evaluation in pediatric ulcerative colitis. (21939916)
2011
24
Assessing disease risk in pediatric ulcerative colitis. (20629182)
2011
25
Cost-effectiveness analysis of adjunct VSL#3 therapy versus standard medical therapy in pediatric ulcerative colitis. (21694634)
2011
26
Mesalamine-induced myocarditis and coronary vasculitis in a pediatric ulcerative colitis patient: a case report. (22611512)
2011
27
Steroid response in moderate to severe pediatric ulcerative colitis: a single center's experience. (21191776)
2011
28
Agreement between patient- and physician-completed Pediatric Ulcerative Colitis Activity Index scores. (21593644)
2011
29
Glucocorticoid bioactivity does not predict response to steroid therapy in severe pediatric ulcerative colitis. (19714760)
2010
30
Severe pediatric ulcerative colitis: a prospective multicenter study of outcomes and predictors of response. (20193683)
2010
31
Increased mucosal expression of GATA-3 and STAT-4 in pediatric ulcerative colitis. (20030749)
2010
32
Mathematical weighting of a clinimetric index (Pediatric Ulcerative Colitis Activity Index) was superior to the judgmental approach. (19124220)
2009
33
The natural history of pediatric ulcerative colitis: a population-based cohort study. (19436273)
2009
34
Severe chest pain in a pediatric ulcerative colitis patient after 5-aminosalicylic acid therapy. (18666333)
2008
35
Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis. (18981162)
2008
36
Mesalamine hypersensitivity and Kounis syndrome in a pediatric ulcerative colitis patient. (19084925)
2008
37
Infliximab for pediatric ulcerative colitis: a retrospective Italian multicenter study. (18598998)
2008
38
Idiopathic thrombocytopenic purpura after colectomy for pediatric ulcerative colitis. (18344179)
2008
39
Short- and long-term response to and weaning from infliximab therapy in pediatric ulcerative colitis. (17325550)
2007
40
Development, validation, and evaluation of a pediatric ulcerative colitis activity index: a prospective multicenter study. (17681163)
2007
41
Infliximab efficacy in pediatric ulcerative colitis. (15735427)
2005
42
Infliximab in pediatric ulcerative colitis: two-year follow-up. (15076630)
2004
43
Infliximab as a novel therapy for pediatric ulcerative colitis. (11964959)
2002
44
Pediatric ulcerative colitis: a review of the disease and current therapy. (9697570)
1998
45
Surgery for pediatric ulcerative colitis. (7663621)
1995
46
Prolonged medical therapy for severe pediatric ulcerative colitis. (7733078)
1995
47
Liver disease in pediatric ulcerative colitis. (7884611)
1995
48
Proctocolectomy and quadruple-limb W pouch reconstruction for the management of pediatric ulcerative colitis and familial polyposis. (8014804)
1994

Variations for Pediatric Ulcerative Colitis

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Expression for genes affiliated with Pediatric Ulcerative Colitis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pediatric Ulcerative Colitis

Search GEO for disease gene expression data for Pediatric Ulcerative Colitis.

Pathways for genes affiliated with Pediatric Ulcerative Colitis

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Sources:
50PathCards, 38NCBI BioSystems Database, 53QIAGEN, 55Reactome, 30KEGG, 60Thomson Reuters
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Pathways related to Pediatric Ulcerative Colitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1PRSS1, TNF
2
Show member pathways
9.1PRSS1, TNF
3
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.0CCL11, TNF
4
Show member pathways
9.0CCL11, TNF

Compounds for genes affiliated with Pediatric Ulcerative Colitis

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 24HMDB, 3BitterDB
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Compounds related to Pediatric Ulcerative Colitis according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1pranlukast45 29 1111.4CCL11, TNF
2groalpha459.4CCL11, TNF
3budesonide45 51 1111.4CCL11, TNF
4fluticasone propionate45 51 61 1112.4CCL11, TNF
5rolipram45 61 2911.4TNF, CCL11
6poly(i-c)459.4CCL11, TNF
7tarc459.4CCL11, TNF
8peptidoglycan45 2910.4CCL11, TNF
9n-formylmethionyl-leucylphenylalanine459.4TNF, CCL11
10ccl345 2910.4CCL11, TNF
1115-deoxy-delta-12,14-prostaglandin j2459.4CCL11, TNF
12leukotriene b445 61 2411.4TNF, CCL11
13prednisolone45 29 1111.4CCL11, TNF
14troglitazone45 29 61 1112.4TNF, CCL11
15herbimycin a45 6110.4CCL11, TNF
16endotoxin459.4CCL11, TNF
17ionomycin459.4CCL11, TNF
18fmlp459.3TNF, CCL11
19prostaglandin459.3CCL11, TNF
20fibrinogen459.3TNF, PRSS1
21tacrolimus45 51 1111.3CCL11, TNF
22rantes459.3CCL11, TNF
23n acetylcysteine459.3TNF, CCL11
24indomethacin45 29 61 1112.3CCL11, TNF
25sb 20358045 6110.3CCL11, TNF
26butyrate459.3CCL11, TNF
27histamine45 29 2411.2CCL11, TNF
28ly294002459.2CCL11, TNF
29actinomycin d459.1CCL11, TNF
30genistein45 29 61 3 24 1114.1TNF, CCL11
31cyclosporin a45 29 6111.0CCL11, TNF
32thymidine45 2410.0CCL11, TNF
33pge2458.9CCL11, TNF
34superoxide45 249.7CCL11, TNF

GO Terms for genes affiliated with Pediatric Ulcerative Colitis

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16Gene Ontology
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Cellular components related to Pediatric Ulcerative Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5CCL11, PRSS1, TNF

Biological processes related to Pediatric Ulcerative Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:0301989.1PRSS1, TNF
2response to virusGO:0096158.9CCL11, TNF
3inflammatory responseGO:0069548.7CCL11, TNF

Products for genes affiliated with Pediatric Ulcerative Colitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pediatric Ulcerative Colitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet