MCID: PDT027
MIFTS: 31

Pediatric Ulcerative Colitis

Categories: Rare diseases

Aliases & Classifications for Pediatric Ulcerative Colitis

MalaCards integrated aliases for Pediatric Ulcerative Colitis:

Name: Pediatric Ulcerative Colitis 49 69
Ulcerative Colitis, Pediatric 49

Classifications:



External Ids:

UMLS 69 C2931173

Summaries for Pediatric Ulcerative Colitis

MalaCards based summary : Pediatric Ulcerative Colitis, also known as ulcerative colitis, pediatric, is related to inflammatory bowel disease and ulcerative colitis. An important gene associated with Pediatric Ulcerative Colitis is CXCL5 (C-X-C Motif Chemokine Ligand 5), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions. The drugs Infliximab and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include colon, monocytes and liver.

Related Diseases for Pediatric Ulcerative Colitis

Diseases related to Pediatric Ulcerative Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 28.3 CCL11 CXCL5 TPMT
2 ulcerative colitis 10.7
3 colitis 10.7
4 mucositis 10.0
5 autoimmune disease 9.9
6 autoimmune disease 1 9.9
7 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
8 myocarditis 9.7
9 vasculitis 9.7
10 cholangitis 9.7
11 pouchitis 9.7
12 cholangitis, primary sclerosing 9.7
13 episodic pain syndrome, familial, 1 9.7
14 liver disease 9.7
15 allergic hypersensitivity disease 9.7
16 sclerosing cholangitis 9.7
17 purpura 9.7

Graphical network of the top 20 diseases related to Pediatric Ulcerative Colitis:



Diseases related to Pediatric Ulcerative Colitis

Symptoms & Phenotypes for Pediatric Ulcerative Colitis

Drugs & Therapeutics for Pediatric Ulcerative Colitis

Drugs for Pediatric Ulcerative Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 4,Phase 3 170277-31-3
2
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4
Nicotine Approved Phase 4 54-11-5 89594 942
5
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
6
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
7
Metronidazole Approved Phase 4 443-48-1 4173
8
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
9
Vancomycin Approved Phase 4 1404-90-6 14969 441141
10
Butyric Acid Experimental, Investigational Phase 4 107-92-6 264
11 Prednisolone acetate Phase 4
12 Mesalamine Phase 4,Phase 3 89-57-6
13 Analgesics Phase 4,Phase 3
14 glucocorticoids Phase 4
15 Methylprednisolone acetate Phase 4
16 Methylprednisolone Hemisuccinate Phase 4
17 Gastrointestinal Agents Phase 4,Phase 3
18 Neuroprotective Agents Phase 4
19 Analgesics, Non-Narcotic Phase 4,Phase 3
20 Hormone Antagonists Phase 4
21 Dermatologic Agents Phase 4,Phase 3
22 Hormones Phase 4
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
24 Peripheral Nervous System Agents Phase 4,Phase 3
25 Antiemetics Phase 4
26 Prednisolone hemisuccinate Phase 4
27 Prednisolone phosphate Phase 4
28 Anti-Inflammatory Agents Phase 4,Phase 3
29 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
30 Protective Agents Phase 4
31 Autonomic Agents Phase 4
32 Antirheumatic Agents Phase 4,Phase 3
33 Anti-Bacterial Agents Phase 4,Phase 3
34 Anti-Infective Agents Phase 4,Phase 3
35 Antibiotics, Antitubercular Phase 4
36 Antiprotozoal Agents Phase 4
37 Antiparasitic Agents Phase 4
38 Antitubercular Agents Phase 4,Phase 3
39 Gentamicins Phase 4
40 Topoisomerase Inhibitors Phase 4
41 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
42 Cytochrome P-450 Enzyme Inhibitors Phase 4
43 Antimalarials Phase 4
44 Antineoplastic Agents, Hormonal Phase 4
45
Adalimumab Approved Phase 3 331731-18-1 16219006
46
Curcumin Approved, Investigational Phase 3 458-37-7 969516
47
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
48
Aminosalicylic Acid Approved Phase 3 65-49-6 4649
49 Antibodies, Monoclonal Phase 3,Phase 1
50 Immunoglobulins Phase 3,Phase 1

Interventional clinical trials:

(show all 33)

# Name Status NCT ID Phase Drugs
1 Once Versus Twice Daily Mesalamine to Induce Remission in Pediatric Ulcerative Colitis Completed NCT01201122 Phase 4 Mesalamine
2 Use of a Novel Diet (UC DIET) for Treatment of Mild to Moderate Active Pediatric Ulcerative Colitis Recruiting NCT02345733 Phase 4 Antibiotic cocktail
3 An Efficacy and Safety Study of Infliximab in Pediatric Participants With Inflammatory Bowel Disease Recruiting NCT02566889 Phase 4 Infliximab
4 Manipulating the Microbiome in IBD by Antibiotics and FMT Active, not recruiting NCT02033408 Phase 4 AB (antibiotics);CS (corticosteroids) Only
5 Clinical Study of TA-650 in Pediatric Patients With Ulcerative Colitis Completed NCT01585155 Phase 3 TA-650
6 Assessing the Safety/Efficacy of Asacol® Given Every 12 Hours to Children and Adolescents With Active Ulcerative Colitis Completed NCT00713310 Phase 3 Asacol 400 mg;Asacol 400 mg
7 A Study of the Safety and Efficacy of Infliximab(REMICADE ) in Pediatric Patients With Moderately to SeverelyActive Ulcerative Colitis Completed NCT00336492 Phase 3
8 Efficacy and Safety of Adalimumab in Pediatric Subjects With Moderate to Severe Ulcerative Colitis Recruiting NCT02065557 Phase 3
9 Long-term Safety and Efficacy Study of Adalimumab in Pediatric Subjects With Ulcerative Colitis Enrolling by invitation NCT02632175 Phase 3
10 Curcumin in Pediatric Ulcerative Colitis Not yet recruiting NCT02277223 Phase 3 Placebo
11 Assessing the Safety/Efficacy of Asacol® Given Every 12 Hours to Children and Adolescents for the Maintenance of Remission of Ulcerative Colitis Terminated NCT01004185 Phase 3 Asacol 400 mg;Asacol 400 mg
12 Fecal Microbiota Transplant (FMT) in Pediatric Active Ulcerative Colitis Recruiting NCT02330653 Phase 1, Phase 2
13 Lactobacillus GG in Pediatric Ulcerative Colitis (UC) Withdrawn NCT00895336 Phase 2
14 Fecal Microbiota Transplantation (FMT) for Treatment of Ulcerative Colitis in Children Completed NCT01947101 Phase 1
15 Bacteriotherapy in Pediatric Inflammatory Bowel Disease Completed NCT01757964 Phase 1
16 Fecal Microbiota Transplantation in Pediatric Patients Completed NCT02108821 Phase 1
17 Pediatric FEcal Microbial Transplant for Ulcerative Colitis Recruiting NCT02487238 Phase 1
18 A Study to Assess the Safety and Pharmacokinetics of Subcutaneously Administered Golimumab, a Human Anti-TNFα Antibody, in Pediatric Patients With Moderate to Severe Active Ulcerative Colitis Active, not recruiting NCT01900574 Phase 1 Golimumab
19 Treatment With the Specific Carbohydrate Diet for Children With Active Crohns Disease and Ulcerative Colitis Unknown status NCT02213835
20 Evaluation Of The Pillcam™ Colon Capsule Endoscopy (Pcce-2) In Pediatric Ulcerative Colitis Completed NCT01740349
21 Efficacy of Infliximab as a Rescue Therapy in Pediatric Acute Severe Colitis Completed NCT02170714
22 Validating NIAAA Screen Guide in YCMC Completed NCT01544218
23 Evaluation of PUCAI Score at Assessment for Mucosal Healing During Clinical Remission in Pediatric Ulcerative Colitis Recruiting NCT03179865
24 Anti-TNF Therapy for Refractory Colitis in Hospitalized Children Recruiting NCT02799615 Infliximab
25 Canadian Children Inflammatory Bowel Disease Network (CIDsCANN) Recruiting NCT02308917
26 Identifying a Sleep Screener for Disease Relapse in Children With Inflammatory Bowel Disease Recruiting NCT02970149
27 Intestinal Ultrasound in Pediatric Inflammatory Bowel Disease Recruiting NCT03026582
28 A 5-year Longitudinal Observational Study of Patients Undergoing Therapy for Inflammatory Bowel Disease Recruiting NCT03251118
29 Microbiota-targeted Diet for Pediatric UC Active, not recruiting NCT02922881
30 Integrated Behavioral Health Innovations in Childhood Chronic Illness Care Delivery Systems Active, not recruiting NCT02740309
31 Mission is Remission®: How Can a Disease Self-management Website Change Care? Enrolling by invitation NCT02694042
32 Personalized Research on Diet in Ulcerative Colitis and Crohn's Disease Not yet recruiting NCT03301311
33 Metabolic Response to Infliximab in Pediatric Ulcerative Colitis Terminated NCT00586807

Search NIH Clinical Center for Pediatric Ulcerative Colitis

Genetic Tests for Pediatric Ulcerative Colitis

Anatomical Context for Pediatric Ulcerative Colitis

MalaCards organs/tissues related to Pediatric Ulcerative Colitis:

38
Colon, Monocytes, Liver, Testes

Publications for Pediatric Ulcerative Colitis

Articles related to Pediatric Ulcerative Colitis:

(show top 50) (show all 97)
# Title Authors Year
1
Molecular Comparison of Adult and Pediatric Ulcerative Colitis Indicates Broad Similarity of Molecular Pathways in Disease Tissue. ( 29401083 )
2018
2
Efficacy and Safety of Adalimumab in Pediatric Ulcerative Colitis: A Real-life Experience from the SIGENP-IBD Registry. ( 29315163 )
2018
3
The Changing Face of Pediatric Ulcerative Colitis: A Population-based Cohort Study. ( 29135823 )
2017
4
Granulomatous Upper Gastrointestinal Inflammation in Pediatric Ulcerative Colitis. ( 28991840 )
2017
5
Clinical and Pathologic Remission of Pediatric Ulcerative Colitis with Serum-Derived Bovine Immunoglobulin Added to the Standard Treatment Regimen. ( 28626380 )
2017
6
Mesalamine Enemas for Induction of Remission in Oral Mesalamine-refractory Pediatric Ulcerative Colitis: A Prospective Cohort Study. ( 28369299 )
2017
7
Subcutaneous Golimumab in Pediatric Ulcerative Colitis: Pharmacokinetics and Clinical Benefit. ( 29140944 )
2017
8
Correlation of endoscopic disease severity with pediatric ulcerative colitis activity index score in children and young adults with ulcerative colitis. ( 28566893 )
2017
9
Fecal Microbial Transplantation for Pediatric Ulcerative Colitis: Are We There Yet? ( 29077649 )
2017
10
Assessment of disease activity in pediatric ulcerative colitis. ( 27145213 )
2016
11
Genetics and Therapeutics in Pediatric Ulcerative Colitis: the Past, Present and Future. ( 26973787 )
2016
12
The association of autoimmune diseases with pediatric ulcerative colitis does not influence its disease course. ( 26152794 )
2016
13
Randomized clinical trial: pharmacokinetics and safety of multimatrix mesalamine for treatment of pediatric ulcerative colitis. ( 26893546 )
2016
14
Difference between early onset and late onset pediatric ulcerative colitis. ( 26833925 )
2016
15
Colectomy in pediatric ulcerative colitis: A single center experience of indications, outcomes, and complications. ( 26653944 )
2016
16
Item Generation and Reduction Towards Developing a Patient Reported Outcome for Pediatric Ulcerative Colitis (TUMMY-UC). ( 27159210 )
2016
17
Prostaglandin E-major Urinary Metabolite as a Biomarker for Pediatric Ulcerative Colitis Activity. ( 27906804 )
2016
18
Capillary Flow Rates in the Duodenum of Pediatric Ulcerative Colitis Patients are Increased and Unrelated to Inflammation. ( 28045777 )
2016
19
Seeing without Looking: Predicting Mucosal Healing without Endoscopic Evaluation in Pediatric Ulcerative Colitis. ( 28045775 )
2016
20
Effect of Early Versus Late Azathioprine Therapy in Pediatric Ulcerative Colitis. ( 27271489 )
2016
21
Pouchitis in Pediatric Ulcerative Colitis Patients After Ileal Pouch Anal Anastomosis. ( 27602702 )
2016
22
Efficacy and safety of granulocyte, monocyte/macrophage adsorptive in pediatric ulcerative colitis. ( 27158208 )
2016
23
Pediatric ulcerative colitis surgery: Italian survey. ( 25895877 )
2015
24
P631. Mesalamine versus azathioprine for maintenance treatment after steroid-induced remission in pediatric ulcerative colitis. ( 25718133 )
2015
25
A MicroRNA Signature in Pediatric Ulcerative Colitis: Deregulation of the miR-4284/CXCL5 Pathway in the Intestinal Epithelium. ( 25738378 )
2015
26
Thalidomide Treatment of Pediatric Ulcerative Colitis: A New Use for an Old Drug. ( 26199988 )
2015
27
Reply to Thalidomide Treatment of Pediatric Ulcerative Colitis: A New Use for an Old Drug. ( 25993695 )
2015
28
Precolectomy Therapy Does Not Alter Histologic Findings Distribution in Resected Colon in Pediatric Ulcerative Colitis. ( 26465789 )
2015
29
A Methodological Approach to Fecal Microbial Transplant via Nasogastric Tube for Active Pediatric Ulcerative Colitis. ( 25822774 )
2015
30
Diagnostic Yield of Routine Enteropathogenic Stool Tests in Pediatric Ulcerative Colitis. ( 26663793 )
2015
31
Serial fecal microbiota transplantation alters mucosal gene expression in pediatric ulcerative colitis. ( 25853207 )
2015
32
The Increased Expression of CCL20 and CCR6 in Rectal Mucosa Correlated to Severe Inflammation in Pediatric Ulcerative Colitis. ( 25691899 )
2015
33
Serum Cytokine Profiling of Leukocytapheresis in Pediatric Ulcerative Colitis. ( 25807968 )
2015
34
Characteristics of pediatric ulcerative colitis in Saudi Arabia: a multicenter national study. ( 26142933 )
2015
35
Combination of oral antibiotics may be effective in severe pediatric ulcerative colitis: A preliminary report. ( 24958064 )
2014
36
Allopurinol: a useful adjunct to thiopurine therapy for pediatric ulcerative colitis in the biologic era. ( 24590210 )
2014
37
Taking Full Measure of the Pediatric Ulcerative Colitis Activity Index (PUCAI). ( 25373859 )
2014
38
Differences in the management of pediatric and adult onset ulcerative colitis - lessons from the joint ECCO and ESPGHAN consensus guidelines for the management of pediatric ulcerative colitis. ( 24230969 )
2014
39
Ultrasonography of the colon in pediatric ulcerative colitis: a prospective, blind, comparative study with colonoscopy. ( 24725581 )
2014
40
Fecal Microbial Transplant via Nasogastric Tube for Active Pediatric Ulcerative Colitis. ( 25162366 )
2014
41
Safe azathioprine treatment in a pediatric ulcerative colitis patient with TPMT*16 by thiopurine metabolite monitoring. ( 25036765 )
2014
42
Clinical course of infliximab treatment in korean pediatric ulcerative colitis patients: a single center experience. ( 24749085 )
2014
43
Pediatric ulcerative colitis: a practical guide to management. ( 24723200 )
2014
44
Steps toward harmonization for clinical development of medicines in pediatric ulcerative colitis-a global scientific discussion, part 1: efficacy endpoints and disease outcome assessments. ( 24866781 )
2014
45
Alternate endpoints and clinical outcome assessments in pediatric ulcerative colitis registration trials. ( 24121142 )
2014
46
Steps toward harmonization for clinical development of medicines in pediatric ulcerative colitis-a global scientific discussion, part 2: data extrapolation, trial design, and pharmacokinetics. ( 24866782 )
2014
47
Second-generation colon capsule endoscopy vs. colonoscopy in pediatric ulcerative colitis: a pilot study. ( 24777427 )
2014
48
DNA methylation-associated colonic mucosal immune and defense responses in treatment-naA^ve pediatric ulcerative colitis. ( 24937444 )
2014
49
Feasibility and Validity of the Pediatric Ulcerative Colitis Activity Index in Routine Clinical Practice. ( 25221935 )
2014
50
Complementary, integrative, and holistic medicine: integrative approaches to pediatric ulcerative colitis. ( 24000344 )
2013

Variations for Pediatric Ulcerative Colitis

Expression for Pediatric Ulcerative Colitis

Search GEO for disease gene expression data for Pediatric Ulcerative Colitis.

Pathways for Pediatric Ulcerative Colitis

Pathways related to Pediatric Ulcerative Colitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.49 CCL11 CXCL5
2
Show member pathways
10.69 CCL11 CXCL5
3 10.19 CCL11 CXCL5

GO Terms for Pediatric Ulcerative Colitis

Biological processes related to Pediatric Ulcerative Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemotaxis GO:0006935 8.96 CCL11 CXCL5
2 chemokine-mediated signaling pathway GO:0070098 8.62 CCL11 CXCL5

Molecular functions related to Pediatric Ulcerative Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.96 CCL11 CXCL5
2 chemokine activity GO:0008009 8.62 CCL11 CXCL5

Sources for Pediatric Ulcerative Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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