MCID: PLL002
MIFTS: 40

Pellagra

Categories: Rare diseases, Metabolic diseases, Skin diseases, Neuronal diseases

Aliases & Classifications for Pellagra

MalaCards integrated aliases for Pellagra:

Name: Pellagra 12 50 56 42 14 69
Niacin-Tryptophan Deficiency 12
Niacin Deficiency 12

Classifications:

Orphanet: 56  
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:8457
ICD10 33 E52
ICD9CM 35 265.2
MeSH 42 D010383
Orphanet 56 ORPHA97352
MESH via Orphanet 43 D010383
UMLS via Orphanet 70 C0030783
ICD10 via Orphanet 34 E52
UMLS 69 C0030783

Summaries for Pellagra

MalaCards based summary : Pellagra, also known as niacin-tryptophan deficiency, is related to pellagra like syndrome and hartnup disorder. An important gene associated with Pellagra is SLC6A19 (Solute Carrier Family 6 Member 19), and among its related pathways/superpathways are NAD metabolism and Fat digestion and absorption. The drugs Etoposide and Vorinostat have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and tongue, and related phenotype is homeostasis/metabolism.

Wikipedia : 72 Pellagra is a disease caused by a lack of the vitamin niacin (vitamin B3). Symptoms include inflamed... more...

Related Diseases for Pellagra

Diseases in the Pellagra family:

Pellagra Like Syndrome

Diseases related to Pellagra via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
id Related Disease Score Top Affiliating Genes
1 pellagra like syndrome 12.0
2 hartnup disorder 11.0
3 encephalopathy 10.1
4 leiomyoma 10.0 ERCC5 PARP1
5 kwashiorkor 10.0
6 dermatitis 10.0
7 crohn's disease 9.9
8 albinism, oculocutaneous, type ia 9.9 CD38 IGF1
9 anorexia nervosa 9.8
10 scurvy 9.8
11 fetal parvovirus syndrome 9.8 APOB IGF1
12 tuberculosis 9.8
13 carcinoid syndrome 9.8
14 cataract 9.7
15 colitis 9.7
16 diarrhea 9.7
17 pernicious anemia 9.7
18 purpura 9.7
19 pancreatitis 9.7
20 neuropathy 9.7
21 schizophrenia 9.5
22 cerebellar ataxia 9.5
23 celiac disease 9.5
24 acrodermatitis enteropathica 9.5
25 multiple myeloma 9.5
26 creutzfeldt-jakob disease 9.5
27 acne 9.5
28 burns 9.5
29 liver disease 9.5
30 thalassemia 9.5
31 mucositis 9.5
32 sarcoma 9.5
33 hemosiderosis 9.5
34 ancylostomiasis 9.5
35 dementia 9.5
36 addison's disease 9.5
37 cheilitis 9.5
38 vulvovaginitis 9.5
39 wernicke encephalopathy 9.5
40 acrodermatitis 9.5
41 pulmonary tuberculosis 9.5
42 cockayne syndrome 9.5
43 food allergy 9.5
44 lipomatosis 9.5
45 atopic dermatitis 9.5
46 plague 9.5
47 conjunctivitis 9.5
48 ariboflavinosis 9.5
49 duodenitis 9.5
50 eating disorder 9.5

Graphical network of the top 20 diseases related to Pellagra:



Diseases related to Pellagra

Symptoms & Phenotypes for Pellagra

MGI Mouse Phenotypes related to Pellagra:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.23 APOB CD38 CES1 DGAT2 ERCC5 IGF1

Drugs & Therapeutics for Pellagra

Drugs for Pellagra (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 1 33419-42-0 36462
2
Vorinostat Approved, Investigational Phase 1 149647-78-9 5311
3
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
4
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
5
Nicotinamide Approved, Nutraceutical Phase 1 98-92-0 936
6 Antimetabolites Phase 1
7 Antineoplastic Agents, Phytogenic Phase 1
8 Etoposide phosphate Phase 1
9 Histone Deacetylase Inhibitors Phase 1
10 Hypolipidemic Agents Phase 1
11 Lipid Regulating Agents Phase 1
12 Micronutrients Phase 1
13 Nicotinic Acids Phase 1
14 Tin Fluorides Phase 1
15 Topoisomerase Inhibitors Phase 1
16 Trace Elements Phase 1
17 Vasodilator Agents Phase 1
18 Vitamin B Complex Phase 1
19 Vitamins Phase 1
20 Folate Nutraceutical Phase 1
21 Vitamin B3 Nutraceutical Phase 1
22 Vitamin B9 Nutraceutical Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Phase I Vorinostat in Combination With Niacinamide and Etoposide for Lymphoid Malignancies Completed NCT00691210 Phase 1 Vorinostat;Niacinamide;Etoposide

Search NIH Clinical Center for Pellagra

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: pellagra

Genetic Tests for Pellagra

Anatomical Context for Pellagra

MalaCards organs/tissues related to Pellagra:

39
Skin, Testes, Tongue, Liver, Small Intestine, Spinal Cord, Pituitary

Publications for Pellagra

Articles related to Pellagra:

(show top 50) (show all 496)
id Title Authors Year
1
An Outbreak of Pellagra in the Kasese Catchment Area, Dowa, Malawi. ( 28219990 )
2017
2
Alcoholic Pellagra as a Cause of Altered Mental Status in the Emergency Department. ( 28736097 )
2017
3
Depletion of Epidermal Langerhans Cells in the Skin Lesions of Pellagra Patients. ( 28291135 )
2017
4
'Shrouded in a dark fog': comparison of the diagnosis of pellagra in Venice and general paralysis of the insane in the United Kingdom, 1840-1900. ( 28468544 )
2017
5
Severe pellagra masked by concurrent plaque psoriasis: a case report of a hidden diagnosis. ( 28537863 )
2017
6
Pellagra: a rare complication of isoniazid therapy. ( 27393553 )
2016
7
Pellagra Secondary to Medication and Alcoholism: A Case Report and Review of the Literature. ( 27491713 )
2016
8
Ethionamide-induced pellagra. ( 25828829 )
2015
9
Pellagra Pre-Goldberger: Rupert Blue, Fleming Sandwith, and The "Vitamine Hypothesis". ( 26330657 )
2015
10
Wernicke encephalopathy and pellagra in an alcoholic and malnourished patient. ( 26490997 )
2015
11
Louis Sambon and the Clash of Pellagra Etiologies in Italy and the United States, 1905-14. ( 25740951 )
2015
12
Challenges for treatment of alcoholic neuropathic symptoms aggravated by niacin treatment of alcoholic pellagra. ( 26323963 )
2015
13
Half-and-half nail in a case of isoniazid-induced pellagra. ( 25395931 )
2014
14
The importance of recognizing pellagra (niacin deficiency) as it still occurs. ( 24679717 )
2014
15
Pellagra and alcoholism: a biochemical perspective. ( 24627570 )
2014
16
Functional abdominal pain causing Scurvy, Pellagra, and Hypovitaminosis A. ( 24715978 )
2014
17
Pellagra encephalopathy in the context of alcoholism: review and case report. ( 23926211 )
2014
18
Livedo reticularis due to pellagra in a two year old child. ( 24891684 )
2014
19
An unexpected case of pellagra. ( 24835720 )
2014
20
Pellagra: a non-eradicated old disease. ( 24847436 )
2014
21
Phenobarbital-induced pellagra resulted in death. ( 24533822 )
2014
22
The Thompson-McFadden Commission and Joseph Goldberger: contrasting 2 historical investigations of pellagra in cotton mill villages in South Carolina. ( 24966221 )
2014
23
Pellagra in a patient with primary SjAPgren's syndrome. ( 24943141 )
2014
24
Black urine due to urobilinogen in a patient with alcoholic pellagra. ( 24709296 )
2014
25
Pellagra in a child--a rare entity. ( 24103522 )
2013
26
Pellagra revealing a congenital duodenal diaphragm in an adult. ( 23168227 )
2013
27
A rare case of alcoholic pellagra encephalopathy with startle myoclonus and marked response to niacin therapy: time for a new dictum? ( 23608853 )
2013
28
Pellagra-like condition is xeroderma pigmentosum/Cockayne syndrome complex and niacin confers clinical benefit. ( 24354460 )
2013
29
Pellagra. A challenging differential diagnosis in burn injuries. ( 24405724 )
2013
30
The neuropsychiatry of pellagra in early American studies. ( 24247868 )
2013
31
Parkinsonian features in a case of pellagra: a historical report. ( 24028927 )
2013
32
A case of pellagra associated with megaduodenum in a young woman. ( 23232750 )
2013
33
Nicotinamide, NAD(P)(H), and Methyl-Group Homeostasis Evolved and Became a Determinant of Ageing Diseases: Hypotheses and Lessons from Pellagra. ( 22536229 )
2012
34
Electrocardiographic enigma of a classical disease: pellagra. ( 23002166 )
2012
35
Pellagra: a clinical, histopathological, and epidemiological study of 7 cases. ( 22456595 )
2012
36
Dermatitis as one of the 3 Ds of pellagra. ( 23218096 )
2012
37
Pellagra. ( 22779101 )
2012
38
Pellagra: a non-communicable disease of poverty. ( 22785547 )
2012
39
Letter: Pellagra as the initial presentation of Crohn disease. ( 22559027 )
2012
40
Pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease. ( 22535301 )
2012
41
Isoniazid-induced pellagra. ( 21517721 )
2011
42
The photosensitive patient: could it be pellagra? ( 21615366 )
2011
43
Azathioprine-induced pellagra. ( 21658113 )
2011
44
Pellagra-like erythema on sun-exposed skin of patients with anorexia nervosa. ( 21592198 )
2011
45
Hoarseness in pellagra. ( 21507655 )
2011
46
Benign symmetrical lipomatosis and pellagra associated with alcoholism. ( 22281911 )
2011
47
Pellagra: a review with emphasis on photosensitivity. ( 21128910 )
2011
48
Commentary: Hoarseness in pellagra. ( 21507651 )
2011
49
Neuropsychiatric symptoms in an early description of pellagra. ( 21037156 )
2010
50
Pellagra: an old enemy of timeless importance. ( 20332283 )
2010

Variations for Pellagra

Expression for Pellagra

Search GEO for disease gene expression data for Pellagra.

Pathways for Pellagra

Pathways related to Pellagra according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.26 ACMSD CD38 KYNU NAPRT PARP1
2
Show member pathways
10.6 APOB DGAT2

GO Terms for Pellagra

Biological processes related to Pellagra according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 nucleotide-excision repair, DNA incision GO:0033683 9.49 ERCC5 PARP1
2 nucleotide-excision repair, DNA incision, 5-to lesion GO:0006296 9.48 ERCC5 PARP1
3 nucleotide-excision repair, preincision complex assembly GO:0006294 9.46 ERCC5 PARP1
4 low-density lipoprotein particle clearance GO:0034383 9.43 APOB DGAT2
5 nucleotide-excision repair, DNA incision, 3-to lesion GO:0006295 9.4 ERCC5 PARP1
6 nucleotide-excision repair, preincision complex stabilization GO:0006293 9.37 ERCC5 PARP1
7 positive regulation of cardiac muscle hypertrophy GO:0010613 9.32 IGF1 PARP1
8 positive regulation of transcription regulatory region DNA binding GO:2000679 9.26 IGF1 PARP1
9 NAD biosynthetic process GO:0009435 9.16 KYNU NAPRT
10 pyridine nucleotide biosynthetic process GO:0019363 8.96 KYNU NAPRT
11 tryptophan catabolic process GO:0006569 8.62 ACMSD KYNU

Sources for Pellagra

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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