Pelvic Inflammatory Disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Pelvic Inflammatory Disease

Sources:
³³MedlinePlus, ⁴CDC, ⁶⁴Wikipedia, ³²MalaCards
See all sources

MedlinePlus:³³ Pelvic inflammatory disease (pid) is an infection and inflammation of the uterus, ovaries, and other female reproductive organs. it causes scarring in these organs. this can lead to infertility, ectopic pregnancy, pelvic pain, abscesses, and other serious problems. pid is the most common preventable cause of infertility in the united states. gonorrhea and chlamydia, two sexually transmitted diseases, are the most common causes of pid. other bacteria can also cause it. you are at greater risk if you are sexually active and younger than 25 have more than one sex partner douche some women have no symptoms. others have pain in the lower abdomen, fever, smelly vaginal discharge, irregular bleeding, and pain during intercourse or urination. doctors diagnose pid with a physical exam, lab tests, and imaging tests. antibiotics can cure pid. early treatment is important. waiting too long increases the risk of infertility. nih: national institute of allergy and infectious diseases

MalaCards based summary: Pelvic Inflammatory Disease, also known as female pelvic inflammatory disease, is related to tuberculosis and cervicitis. An important gene associated with Pelvic Inflammatory Disease is HSPD1 (heat shock 60kDa protein 1 (chaperonin)), and among its related pathways are MAPK Pathway and NF-kappaB Signaling. The compounds pam2csk4 and pam3csk4 have been mentioned in the context of this disorder. Affiliated tissues include ovary, uterus and testes, and related mouse phenotypes are immune system and hematopoietic system.

CDC:⁴ Basic Fact Sheet | Detailed Version

Wikipedia:⁶⁴ Pelvic inflammatory disease (or disorder) (PID) is a term for inflammation of the uterus, fallopian... more...

Aliases & Classifications for Pelvic Inflammatory Disease

Sources:
⁹Disease Ontology, ¹¹DISEASES, ⁴⁴Novoseek, ³³MedlinePlus, ⁶¹UMLS, ⁵⁶SNOMED-CT, ²⁸ICD9CM, ³⁹NCIt, ³⁴MeSH, ²⁶ICD10
See all sources

Pelvic Inflammatory Disease, Aliases & Descriptions:

Name: Pelvic Inflammatory Disease ⁹ ¹¹ ⁴⁴ ³³ ⁶¹

Female Pelvic Inflammatory Disease ⁹ ⁶¹

Inflammatory Disease of Female Pelvic Organs and/or Tissues ⁹

Pid ⁹

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases

ICD10: ²⁶

Diseases of the genitourinary system

Inflammatory diseases of female pelvic organs

Female pelvic inflammatory disorders in diseases classified elsewhere

Female pelvic inflammatory disorders in other diseases classified elsewhere

Other female pelvic inflammatory diseases

Other specified female pelvic inflammatory diseases

External Ids:

Disease Ontology⁹ DOID:1003

ICD9CM²⁸ 614-616.99, 614.9

NCIt³⁹ C3889

SNOMED-CT⁵⁶ 266651008, 198178006, 198244005 155968004, 37518008, 198130006, 198131005, 155967009, 266648001, 155986001, 155974004, 198570007, 266584000, more

MeSH³⁴ D000292

ICD10²⁶ N74, N73.8, N74.8

UMLS⁶¹ C0242172

Related Diseases for Pelvic Inflammatory Disease

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Pelvic Inflammatory Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 49)

id	Related Disease	Score	Top Affiliating Genes
1	tuberculosis	29.9	TLR1, HSPD1, TIRAP
2	cervicitis	10.6
3	infertility	10.6
4	endometritis	10.5
5	ectopic pregnancy	10.5
6	gonorrhea	10.5
7	endometriosis	10.5
8	vaginitis	10.5
9	bacterial vaginosis	10.4
10	ovarian cancer	10.4
11	peritonitis	10.4
12	salpingitis	10.4
13	fitz-hugh-curtis syndrome	10.4
14	colorectal cancer	10.3
15	hepatitis	10.3
16	myocardial infarction	10.3
17	irritable bowel syndrome	10.3
18	urethritis	10.3
19	pneumonia	10.3
20	appendicitis	10.2
21	herpes simplex	10.2
22	sepsis	10.2
23	blindness	10.2
24	epididymitis	10.2
25	malt lymphoma	10.1	TLR1, HSPD1
26	cervical cancer	10.1
27	obesity	10.1
28	skin disease	10.1
29	familial mediterranean fever	10.1
30	vulvovaginitis	10.1
31	nocardiosis	10.1
32	trichomoniasis	10.1
33	endocervicitis	10.1
34	pyosalpinx	10.1
35	ureteral obstruction	10.1
36	portal vein thrombosis	10.1
37	acute female pelvic peritonitis	10.1
38	small cell carcinoma	10.1
39	pancytopenia	10.1
40	ureterocele	10.1
41	actinomycosis	10.1
42	adenoma	10.1
43	ovarian cyst	10.1
44	uterine fibroid	10.1
45	vaginal discharge	10.1
46	benign multicystic peritoneal mesothelioma	10.1
47	meralgia paresthetica	10.1
48	leukopenia	10.1
49	oophoritis	10.0

Graphical network of the top 20 diseases related to Pelvic Inflammatory Disease:

Symptoms for Pelvic Inflammatory Disease

Drugs & Therapeutics for Pelvic Inflammatory Disease

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Pelvic Inflammatory Disease

Search NIH Clinical Center for Pelvic Inflammatory Disease

Genetic Tests for Pelvic Inflammatory Disease

Anatomical Context for Pelvic Inflammatory Disease

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Pelvic Inflammatory Disease:

³²

Ovary, Uterus, Testes, Neutrophil, Colon, Breast, Skin, Monocytes, T cells

Animal Models for Pelvic Inflammatory Disease or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Pelvic Inflammatory Disease:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system phenotype	MP:0005387	8.4	CHI3L1, TIRAP, TLR1, TLR6
2	hematopoietic system phenotype	MP:0005397	8.1	CHI3L1, TIRAP, TLR1, TLR6

Publications for Pelvic Inflammatory Disease

Sources:
⁵¹PubMed
See all sources

Articles related to Pelvic Inflammatory Disease:

(show top 50) (show all 528)

id	Title	Authors	Year
1	A cross-sectional study showing differences in the clinical diagnosis of pelvic inflammatory disease according to the experience of clinicians: implications for training and audit. (24982265)	Morris G.C.... Wilson J.D.	2014
2	Pelvic inflammatory disease. (23704128)	Bartlett E.C.... Munday P.E.	2013
3	Does bacterial vaginosis cause pelvic inflammatory disease? (23324974)	Taylor B.D.... Haggerty C.L.	2013
4	Factors that predict poor clinical course among patients hospitalized with pelvic inflammatory disease. (24118399)	Terao M.... Kozuma S.	2013
5	Risk of myocardial infarction in women with pelvic inflammatory disease. (22265583)	Liou T.H.... Lin H.W.	2013
6	Primary abdominal nocardiosis masquerading as tubercular pelvic inflammatory disease in an immunocompetent individual. (23355581)	Naha K.... Prabhu M.	2013
7	Describing the progression from Chlamydia trachomatis and Neisseria gonorrhoeae to pelvic inflammatory disease: systematic review of mathematical modeling studies. (22801346)	Herzog S.A.... Low N.	2012
8	Significant elevation of plasma pentraxin 3 in patients with pelvic inflammatory disease. (21679133)	Chang C.C.... Hsieh Y.H.	2011
9	Small bowel obstruction secondary to pelvic inflammatory disease. (21679543)	Harris C.... Lambrianides A.L.	2011
10	Side effects of doxycycline in adolescents treated for pelvic inflammatory disease. (21601804)	Risser W.	2011
11	Clinical eficacy of placentrex injection in pelvic inflammatory disease. (20839572)	Agarwal N.... Kriplan A.	2010
12	Toward improving the diagnosis and the treatment of adolescent pelvic inflammatory disease in emergency departments: results of a brief, educational intervention. (20094001)	Balamuth F.... Mollen C.	2010
13	Results of a randomized controlled trial of a brief behavioral intervention for pelvic inflammatory disease in adolescents. (19733100)	Trent M.... Ellen J.M.	2010
14	Management of first-episode pelvic inflammatory disease in primary care: results from a large UK primary care database. (20883614)	Nicholson A.... Cassell J.	2010
15	Significant elevation of plasma matrix metalloproteinase-9 level and its ratio to matrix metalloproteinase-2 in patients with pelvic inflammatory disease. (18937938)	Wang P.H.... Hsieh Y.S.	2009
16	Pelvic inflammatory disease. (19450319)	Ross J.D.	2008
17	Possible association between acute pelvic inflammatory disease in pregnant women and congenital abnormalities in their offspring: a population-based case-control study. (18553461)	Acs N.... Czeizel A.E.	2008
18	Pelvic inflammatory disease attributable to the IUD: modeling risk in West Africa. (18342643)	Stanback J.... Shelton J.D.	2008
19	Predictors of tuboovarian abscess in acute pelvic inflammatory disease. (18251360)	Halperin R.... Pansky M.	2008
20	An audit on the management of pelvic inflammatory disease in the West Midlands, UK. (17945054)	Walzman M.... Ross J.D.	2007
21	Trends in clinical encounters for pelvic inflammatory disease and epididymitis in a national sample of Australian general practices. (16734959)	Chen M.Y.... Donovan B.	2006
22	Pelvic inflammatory disease. (16973083)	Ross J.	2006
23	Pelvic inflammatory disease. (17099803)	Dayan L.	2006
24	Moxifloxacin versus ofloxacin plus metronidazole in uncomplicated pelvic inflammatory disease: results of a multicentre, double blind, randomised trial. (16723364)	Ross J.D.... Reimnitz P.	2006
25	Beta hemolytic streptococcus group f causing pelvic inflammatory disease in a 14-year-old girl. (15897109)	Algren S.D.... Strickland J.L.	2005
26	Pelvic inflammatory disease in adolescents. (16044391)	Banikarim C.... Chacko M.R.	2005
27	Increased activity of lysosomal enzymes in the peritoneal fluid of patients with gynecologic cancers and pelvic inflammatory disease. (15785934)	Beratis N.G.... Tzingounis V.A.	2005
28	Condom use and the risk of recurrent pelvic inflammatory disease, chronic pelvic pain, or infertility following an episode of pelvic inflammatory disease. (15284036)	Ness R.B.... Kip K.E.	2004
29	Irritable bowel syndrome, chronic pelvic inflammatory disease and endometriosis: a comparison of symptomatology. (15618831)	Lea R.... Whorwell P.J.	2004
30	Investigating the microbial aetiology of pelvic inflammatory disease. (14573844)	Taylor-Robinson D.	2003
31	Pelvic inflammatory disease and sepsis. (12597041)	Dulin J.D.... Akers M.C.	2003
32	Endometritis does not predict reproductive morbidity after pelvic inflammatory disease. (12548208)	Haggerty C.L.... Trucco G.	2003
33	Pelvic inflammatory disease. (12772359)	Ooi C.... Dayan L.	2003
34	Pediatric management problems. Pelvic inflammatory disease. (12964672)	Belkengren R.... Sapala S.	2001
35	Risk factors for pelvic inflammatory disease in inner-city adolescents. (10821603)	Suss A.L.... Bromberg K.	2000
36	Successful pregnancy outcome following first trimester pelvic inflammatory disease. (10925910)	Stitely M.L.... Gherman R.B.	2000
37	Pediatric emergency medicine physicians' compliance with Centers for Disease Control and Prevention's guidelines for treatment of pelvic inflammatory disease. (9895011)	Segal G.S.	1999
38	The association of interleukin 6 with clinical and laboratory parameters of acute pelvic inflammatory disease. (10521758)	Richter H.E.... Miller K.B.	1999
39	Relationship between use of the intrauterine device and pelvic inflammatory disease. (10333811)	Sarma S.	1999
40	Pelvic inflammatory disease: the importance of aggressive treatment in adolescents. (9679392)	Rome E.S.	1998
41	Clinical and laparoscopy diagnosis of acute pelvic inflammatory disease in Nigeria. (15512079)	Arowojolu A.O.... Ilesanmi A.O.	1998
42	Hospitalizations for pelvic inflammatory disease in Canada, 1983/84-1993/94. (9494222)	Kurtz R.... Doherty J.	1998
43	Pelvic inflammatory disease in Rhode Island: epidemiology, diagnosis and therapy. (9350116)	Peipert J.F.... Phipps M.G.	1997
44	Prevalence and correlates of antibody to chlamydial heat shock protein in women attending sexually transmitted disease clinics and women with confirmed pelvic inflammatory disease. (9180186)	Eckert L.O.... Stamm W.E.	1997
45	The adolescent with pelvic inflammatory disease: assessment and management. (9055318)	Ivey J.B.	1997
46	Pelvic inflammatory disease: a review. (11364742)	Cassell J.... Adler M.	1997
47	On "Pelvic inflammatory disease in patients seropositive for HIV". (8891629)	Oosterhuis J.W.	1996
48	Intrauterine devices and pelvic inflammatory disease: evolving perspectives on the data. (8972501)	Burkman R.T.	1996
49	Randomized comparison of ampicillin-sulbactam to cefoxitin and doxycycline or clindamycin and gentamicin in the treatment of pelvic inflammatory disease or endometritis. (8190448)	McGregor J.A.... Gibbs R.S.	1994
50	Fitz-Hugh-Curtis Syndrome: pelvic inflammatory disease with an unusual CT presentation. (1522282)	Romo L.V.... Clarke P.D.	1992

Genes related to Pelvic Inflammatory Disease

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Pelvic Inflammatory Disease:

- Elite gene

id	Symbol	Description	Score	Implication
1	HSPD1	heat shock 60kDa protein 1 (chaperonin)	21.74	GeneCards inferred via : Publications, Disorders (show sections)
2	TLR1	toll-like receptor 1	18.32	GeneCards inferred via : Publications (show sections)
3	TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	14.99	GeneCards inferred via : Publications (show sections)
4	CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	11.66	GeneCards inferred via : Publications (show sections)
5	MAN1B1	mannosidase, alpha, class 1B, member 1	8.32	GeneCards inferred via : Publications (show sections)
6	TLR6	toll-like receptor 6	4.99	GeneCards inferred via : Publications (show sections)

Products for genes related to Pelvic Inflammatory Disease disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	6	-	6	6
2	Novus Biologicals	6	6	6	-

Variations for Pelvic Inflammatory Disease

Expression for genes affiliated with Pelvic Inflammatory Disease

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Pelvic Inflammatory Disease

Search GEO for disease gene expression data for Pelvic Inflammatory Disease.

Pathways for genes affiliated with Pelvic Inflammatory Disease

Sources:
⁴⁹PathCards, ⁶⁰Tocris Bioscience, ⁵Cell Signaling Technology, ⁵²QIAGEN, ⁵⁵SinoBiological, ⁵³R&D Systems, ³⁷NCBI BioSystems Database, ⁵⁹Thomson Reuters, ³⁰KEGG
See all sources

Pathways related to Pelvic Inflammatory Disease according to GeneCards/GeneDecks:

(show all 13)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	MAPK Pathway⁶⁰ Show member pathways Toll-like Receptor Pathway⁶⁰	9.5	TLR6, TLR1
2	NF-kappaB Signaling⁵	9.5	TLR6, TLR1
3	Colorectal Cancer Metastasis⁵²	9.5	TLR1, TLR6
4	TNF Signaling⁵⁵ Show member pathways NF-kB (NFkB) Pathway⁵⁵ TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions⁵³ Death Receptor Signaling⁵⁵	9.5	TLR6, TLR1
5	Phagocytosis of Microbes⁵²	9.5	TLR1, TLR6
6	Th17 Differentiation⁵³ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types⁵³	9.5	TLR1, TLR6
7	Th1 Differentiation⁵³ Show member pathways IL27-mediated signaling events³⁷	9.5	TLR6, TLR1
8	TRAF Pathway⁵² Show member pathways TNF Superfamily Pathway⁵² Toll-Like Receptors Pathway⁵²	9.0	TLR1, TLR6, TIRAP
9	Immune response Bacterial infections in normal airways⁵⁹ Show member pathways Transcription NF kB signaling pathway⁵⁹ Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response⁵⁹ Bacterial infections in CF airways⁵⁹ IL 1 beta dependent CFTR expression⁵⁹	9.0	TIRAP, TLR6, TLR1
10	NOD-like Receptor Signaling Pathways⁵³ Show member pathways Toll-Like receptor Signaling Pathways⁵³ Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways⁵³ Inflammasome Activation Pathways⁵³ Mucin expression in CF via TLRs, EGFR signaling pathways⁵⁹ IL-1 Family Signaling Pathways⁵³ Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways⁵⁹ Immune response IL 1 signaling pathway⁵⁹	9.0	TLR6, TLR1, TIRAP
11	Toll-like receptor signaling pathway³⁰ Show member pathways Chagas disease (American trypanosomiasis)³⁰ Toll-like receptor signaling pathway³⁷ Regulation of toll-like receptor signaling pathway³⁷ Hepatitis B³⁰	9.0	TIRAP, TLR1, TLR6
12	Akt Signaling⁵² Show member pathways p38 Signaling⁵² Tec Kinases Signaling⁵²	9.0	TLR6, TLR1, TIRAP
13	Tuberculosis³⁰	8.6	TLR6, TLR1, HSPD1, TIRAP

Compounds for genes affiliated with Pelvic Inflammatory Disease

Sources:
⁶⁰Tocris Bioscience, ⁴⁴Novoseek, ²⁹IUPHAR, ¹²DrugBank
See all sources

Compounds related to Pelvic Inflammatory Disease according to GeneCards/GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	pam2csk4⁶⁰	9.6	TLR6, TLR1
2	pam3csk4⁶⁰	9.6	TLR6, TLR1
3	poly(i:c)⁶⁰	9.5	TLR6, TLR1
4	peptidoglycan⁴⁴ ²⁹	10.5	TLR6, TLR1
5	resiquimod⁴⁴ ⁶⁰	10.4	TLR6, TLR1
6	flagellin⁴⁴ ²⁹	10.2	HSPD1, TLR1, TLR6
7	imiquimod⁴⁴ ⁶⁰ ²⁹ ¹²	12.2	TLR6, TLR1

GO Terms for genes affiliated with Pelvic Inflammatory Disease

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Pelvic Inflammatory Disease according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	phagocytic vesicle membrane	GO:030670	9.5	TLR1, TLR6

Biological processes related to Pelvic Inflammatory Disease according to GeneCards/GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	detection of triacyl bacterial lipopeptide	GO:042495	9.8	TLR6, TLR1
2	positive regulation of interleukin-12 production	GO:032735	9.7	HSPD1, TIRAP
3	toll-like receptor TLR1:TLR2 signaling pathway	GO:038123	9.6	TIRAP, TLR6
4	toll-like receptor TLR6:TLR2 signaling pathway	GO:038124	9.5	TIRAP, TLR6
5	activation of NF-kappaB-inducing kinase activity	GO:007250	9.5	TLR6, CHI3L1
6	toll-like receptor 2 signaling pathway	GO:034134	9.5	TLR6, TIRAP
7	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO:043123	9.4	TLR6, TIRAP
8	toll-like receptor 4 signaling pathway	GO:034142	9.3	TLR6, TIRAP
9	MyD88-dependent toll-like receptor signaling pathway	GO:002755	9.3	TLR6, HSPD1, TIRAP
10	positive regulation of interleukin-6 biosynthetic process	GO:045410	9.3	TIRAP, TLR1, TLR6
11	toll-like receptor signaling pathway	GO:002224	9.2	TLR1, TIRAP, TLR6
12	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.0	CHI3L1, TIRAP
13	innate immune response	GO:045087	9.0	TLR6, TIRAP, TLR1
14	inflammatory response	GO:006954	8.6	TLR6, TLR1, TIRAP, CHI3L1

Molecular functions related to Pelvic Inflammatory Disease according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane signaling receptor activity	GO:004888	9.5	TLR1, TLR6
2	protein heterodimerization activity	GO:046982	8.7	TIRAP, TLR1, TLR6

Products for genes affiliated with Pelvic Inflammatory Disease

Antibodies
Proteins
Lysates

Antibodies
Proteins
Kits and Assays

Sources for Pelvic Inflammatory Disease

¹antibodies-online

²BioGPS

³BitterDB

⁴CDC

⁵Cell Signaling Technology

⁶ClinicalTrials

⁷Clinvar

⁸dbSNP

⁹Disease Ontology

¹⁰diseasecard

¹¹DISEASES

¹²DrugBank

¹³EMD Millipore

¹⁴ExPASy

¹⁵FMA

¹⁶Gene Expression Omnibus DataSets

¹⁷Gene Ontology

¹⁸GeneCards

¹⁹GeneDecks

²⁰GeneReviews

²¹GeneTests

²²Genetics Home Reference

²³GTR

²⁴HGMD

²⁵HMDB

²⁶ICD10

²⁷ICD10 via Orphanet

²⁸ICD9CM

²⁹IUPHAR

³⁰KEGG

³¹LifeMap Discovery®

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PathCards

⁵⁰PharmGKB

⁵¹PubMed

⁵²QIAGEN

⁵³R&D Systems

⁵⁴Reactome

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸The Human Phenotype Ontology

⁵⁹Thomson Reuters

⁶⁰Tocris Bioscience

⁶¹UMLS

⁶²UMLS via Orphanet

⁶³UniProtKB/Swiss-Prot

⁶⁴Wikipedia

PID MCID: PLV003 MIFTS: 50	Pelvic Inflammatory Disease (PID) malady Reproductive diseases category
6 genes, 9 tissues, 49 related diseases, clinical trials Download this MalaCard Expand all tables

Pelvic Inflammatory Disease (PID) malady