PID
MCID: PLV003
MIFTS: 51

Pelvic Inflammatory Disease (PID) malady

Reproductive diseases category
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Summaries for Pelvic Inflammatory Disease

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Sources:
34MedlinePlus, 4CDC, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Pelvic inflammatory disease (pid) is an infection and inflammation of the uterus, ovaries, and other female reproductive organs. it causes scarring in these organs. this can lead to infertility, ectopic pregnancy, pelvic pain, abscesses, and other serious problems. pid is the most common preventable cause of infertility in the united states. gonorrhea and chlamydia, two sexually transmitted diseases, are the most common causes of pid. other bacteria can also cause it. you are at greater risk if you are sexually active and younger than 25 have more than one sex partner douche some women have no symptoms. others have pain in the lower abdomen, fever, smelly vaginal discharge, irregular bleeding, and pain during intercourse or urination. doctors diagnose pid with a physical exam, lab tests, and imaging tests. antibiotics can cure pid. early treatment is important. waiting too long increases the risk of infertility. nih: national institute of allergy and infectious diseases

MalaCards: Pelvic Inflammatory Disease, also known as inflammatory disease of female pelvic organs and/or tissues, is related to tuberculosis and cervicitis. An important gene associated with Pelvic Inflammatory Disease is HSPD1 (heat shock 60kDa protein 1 (chaperonin)), and among its related pathways are MAPK Pathway and NF-kappaB Signaling. The compounds pam2csk4 and pam3csk4 have been mentioned in the context of this disorder. Affiliated tissues include ovary, uterus and testes, and related mouse phenotypes are immune system and hematopoietic system.

CDC:4 Basic Fact Sheet | Detailed Version

Wikipedia:65 Pelvic inflammatory disease (or disorder) (PID) is a term for inflammation of the uterus, fallopian... more...

Aliases & Classifications for Pelvic Inflammatory Disease

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8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 27ICD9CM, 58SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
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Related Diseases for Pelvic Inflammatory Disease

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Pelvic Inflammatory Disease:



Diseases related to pelvic inflammatory disease

Symptoms for Pelvic Inflammatory Disease

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Drugs & Therapeutics for Pelvic Inflammatory Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Pelvic Inflammatory Disease

Search NIH Clinical Center for Pelvic Inflammatory Disease

Genetic Tests for Pelvic Inflammatory Disease

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Anatomical Context for Pelvic Inflammatory Disease

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33MalaCards
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MalaCards organs/tissues related to Pelvic Inflammatory Disease:

33
Ovary, Uterus, Testes, Colon, Breast, Skin, Monocytes, T cells

Animal Models for Pelvic Inflammatory Disease or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Pelvic Inflammatory Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.4CHI3L1, TIRAP, TLR1, TLR6
2MP:00053978.1CHI3L1, TIRAP, TLR1, TLR6

Publications for Pelvic Inflammatory Disease

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52PubMed
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Articles related to Pelvic Inflammatory Disease:

(show top 50)    (show all 499)
idTitleAuthorsYear
1
Pelvic inflammatory disease. (23704128)
2013
2
Does bacterial vaginosis cause pelvic inflammatory disease? (23324974)
2013
3
Factors that predict poor clinical course among patients hospitalized with pelvic inflammatory disease. (24118399)
2013
4
Risk of myocardial infarction in women with pelvic inflammatory disease. (22265583)
2013
5
Primary abdominal nocardiosis masquerading as tubercular pelvic inflammatory disease in an immunocompetent individual. (23355581)
2013
6
Describing the progression from Chlamydia trachomatis and Neisseria gonorrhoeae to pelvic inflammatory disease: systematic review of mathematical modeling studies. (22801346)
2012
7
Significant elevation of plasma pentraxin 3 in patients with pelvic inflammatory disease. (21679133)
2011
8
Small bowel obstruction secondary to pelvic inflammatory disease. (21679543)
2011
9
Side effects of doxycycline in adolescents treated for pelvic inflammatory disease. (21601804)
2011
10
Clinical eficacy of placentrex injection in pelvic inflammatory disease. (20839572)
2010
11
Toward improving the diagnosis and the treatment of adolescent pelvic inflammatory disease in emergency departments: results of a brief, educational intervention. (20094001)
2010
12
Results of a randomized controlled trial of a brief behavioral intervention for pelvic inflammatory disease in adolescents. (19733100)
2010
13
Management of first-episode pelvic inflammatory disease in primary care: results from a large UK primary care database. (20883614)
2010
14
Significant elevation of plasma matrix metalloproteinase-9 level and its ratio to matrix metalloproteinase-2 in patients with pelvic inflammatory disease. (18937938)
2009
15
Pelvic inflammatory disease. (19450319)
2008
16
Possible association between acute pelvic inflammatory disease in pregnant women and congenital abnormalities in their offspring: a population-based case-control study. (18553461)
2008
17
Pelvic inflammatory disease attributable to the IUD: modeling risk in West Africa. (18342643)
2008
18
Predictors of tuboovarian abscess in acute pelvic inflammatory disease. (18251360)
2008
19
An audit on the management of pelvic inflammatory disease in the West Midlands, UK. (17945054)
2007
20
Trends in clinical encounters for pelvic inflammatory disease and epididymitis in a national sample of Australian general practices. (16734959)
2006
21
Pelvic inflammatory disease. (16973083)
2006
22
Pelvic inflammatory disease. (17099803)
2006
23
Moxifloxacin versus ofloxacin plus metronidazole in uncomplicated pelvic inflammatory disease: results of a multicentre, double blind, randomised trial. (16723364)
2006
24
Beta hemolytic streptococcus group f causing pelvic inflammatory disease in a 14-year-old girl. (15897109)
2005
25
Pelvic inflammatory disease in adolescents. (16044391)
2005
26
Increased activity of lysosomal enzymes in the peritoneal fluid of patients with gynecologic cancers and pelvic inflammatory disease. (15785934)
2005
27
Condom use and the risk of recurrent pelvic inflammatory disease, chronic pelvic pain, or infertility following an episode of pelvic inflammatory disease. (15284036)
2004
28
Irritable bowel syndrome, chronic pelvic inflammatory disease and endometriosis: a comparison of symptomatology. (15618831)
2004
29
Investigating the microbial aetiology of pelvic inflammatory disease. (14573844)
2003
30
Pelvic inflammatory disease and sepsis. (12597041)
2003
31
Pelvic inflammatory disease. (12772359)
2003
32
Pediatric management problems. Pelvic inflammatory disease. (12964672)
2001
33
Risk factors for pelvic inflammatory disease in inner-city adolescents. (10821603)
2000
34
Successful pregnancy outcome following first trimester pelvic inflammatory disease. (10925910)
2000
35
Pediatric emergency medicine physicians' compliance with Centers for Disease Control and Prevention's guidelines for treatment of pelvic inflammatory disease. (9895011)
1999
36
The association of interleukin 6 with clinical and laboratory parameters of acute pelvic inflammatory disease. (10521758)
1999
37
Relationship between use of the intrauterine device and pelvic inflammatory disease. (10333811)
1999
38
The rate of diagnosis and demography of pelvic inflammatory disease in general practice: England and Wales. (10454179)
1999
39
Pelvic inflammatory disease: the importance of aggressive treatment in adolescents. (9679392)
1998
40
Clinical and laparoscopy diagnosis of acute pelvic inflammatory disease in Nigeria. (15512079)
1998
41
Hospitalizations for pelvic inflammatory disease in Canada, 1983/84-1993/94. (9494222)
1998
42
Pelvic inflammatory disease in Rhode Island: epidemiology, diagnosis and therapy. (9350116)
1997
43
Prevalence and correlates of antibody to chlamydial heat shock protein in women attending sexually transmitted disease clinics and women with confirmed pelvic inflammatory disease. (9180186)
1997
44
The adolescent with pelvic inflammatory disease: assessment and management. (9055318)
1997
45
Pelvic inflammatory disease: a review. (11364742)
1997
46
Oral clindamycin and ciprofloxacin versus intramuscular ceftriaxone and oral doxycycline in the treatment of mild-to-moderate pelvic inflammatory disease in outpatients. (9114143)
1997
47
On "Pelvic inflammatory disease in patients seropositive for HIV". (8891629)
1996
48
Intrauterine devices and pelvic inflammatory disease: evolving perspectives on the data. (8972501)
1996
49
Randomized comparison of ampicillin-sulbactam to cefoxitin and doxycycline or clindamycin and gentamicin in the treatment of pelvic inflammatory disease or endometritis. (8190448)
1994
50
Fitz-Hugh-Curtis Syndrome: pelvic inflammatory disease with an unusual CT presentation. (1522282)
1992

Variations for Pelvic Inflammatory Disease

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Expression for genes affiliated with Pelvic Inflammatory Disease

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pelvic Inflammatory Disease

Search GEO for disease gene expression data for Pelvic Inflammatory Disease.

Pathways for genes affiliated with Pelvic Inflammatory Disease

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Sources:
50PathCards, 61Tocris Bioscience, 5Cell Signaling Technology, 53QIAGEN, 57SinoBiological, 54R&D Systems, 38NCBI BioSystems Database, 60Thomson Reuters, 30KEGG
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Pathways related to Pelvic Inflammatory Disease according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5TLR6, TLR1
29.5TLR1, TLR6
39.5TLR1, TLR6
4
Show member pathways
9.5TLR1, TLR6
59.5TLR1, TLR6
6
Show member pathways
9.5TLR1, TLR6
7
Show member pathways
IL27-mediated signaling events38
9.5TLR6, TLR1
8
Show member pathways
9.0TLR6, TLR1, TIRAP
9
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.0TIRAP, TLR1, TLR6
10
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.0TIRAP, TLR1, TLR6
11
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.0TIRAP, TLR1, TLR6
12
Show member pathways
9.0TIRAP, TLR1, TLR6
138.6TIRAP, HSPD1, TLR1, TLR6

Compounds for genes affiliated with Pelvic Inflammatory Disease

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Sources:
61Tocris Bioscience, 45Novoseek, 29IUPHAR, 11DrugBank
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Compounds related to Pelvic Inflammatory Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pam2csk4619.6TLR6, TLR1
2pam3csk4619.6TLR6, TLR1
3poly(i:c)619.5TLR6, TLR1
4peptidoglycan45 2910.5TLR1, TLR6
5resiquimod45 6110.4TLR1, TLR6
6flagellin45 2910.2HSPD1, TLR1, TLR6
7imiquimod45 61 29 1112.2TLR1, TLR6

GO Terms for genes affiliated with Pelvic Inflammatory Disease

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16Gene Ontology
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Cellular components related to Pelvic Inflammatory Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phagocytic vesicle membraneGO:0306709.5TLR1, TLR6

Biological processes related to Pelvic Inflammatory Disease according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1detection of triacyl bacterial lipopeptideGO:0424959.8TLR1, TLR6
2positive regulation of interleukin-12 productionGO:0327359.7HSPD1, TIRAP
3toll-like receptor TLR1:TLR2 signaling pathwayGO:0381239.6TIRAP, TLR6
4toll-like receptor TLR6:TLR2 signaling pathwayGO:0381249.5TIRAP, TLR6
5activation of NF-kappaB-inducing kinase activityGO:0072509.5CHI3L1, TLR6
6toll-like receptor 2 signaling pathwayGO:0341349.5TIRAP, TLR6
7positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.4TIRAP, TLR6
8toll-like receptor 4 signaling pathwayGO:0341429.3TIRAP, TLR6
9MyD88-dependent toll-like receptor signaling pathwayGO:0027559.3TLR6, HSPD1, TIRAP
10positive regulation of interleukin-6 biosynthetic processGO:0454109.3TIRAP, TLR1, TLR6
11toll-like receptor signaling pathwayGO:0022249.2TIRAP, TLR1, TLR6
12positive regulation of ERK1 and ERK2 cascadeGO:0703749.0CHI3L1, TIRAP
13innate immune responseGO:0450879.0TLR6, TLR1, TIRAP
14inflammatory responseGO:0069548.6TLR6, TLR1, TIRAP, CHI3L1

Molecular functions related to Pelvic Inflammatory Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048889.5TLR1, TLR6
2protein heterodimerization activityGO:0469828.7TIRAP, TLR1, TLR6

Products for genes affiliated with Pelvic Inflammatory Disease

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  • Antibodies
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  • Antibodies

Sources for Pelvic Inflammatory Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet