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MCID: PLV003
MIFTS: 56

Pelvic Inflammatory Disease

Categories: Reproductive diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Pelvic Inflammatory Disease

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MalaCards integrated aliases for Pelvic Inflammatory Disease:

Name: Pelvic Inflammatory Disease 12 72 51 40 3 41 14 69
Pid 12 3

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 32


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Summaries for Pelvic Inflammatory Disease

About this section
MedlinePlus : 40 Pelvic inflammatory disease (PID) is an infection and inflammation of the uterus, ovaries, and other female reproductive organs. It causes scarring in these organs. This can lead to infertility, ectopic pregnancy, pelvic pain, abscesses, and other serious problems. PID is the most common preventable cause of infertility in the United States. Gonorrhea and chlamydia, two sexually transmitted diseases, are the most common causes of PID. Other bacteria can also cause it. You are at greater risk if you Are sexually active and younger than 25 Have more than one sex partner Douche Some women have no symptoms. Others have pain in the lower abdomen, fever, smelly vaginal discharge, irregular bleeding, and pain during intercourse or urination. Doctors diagnose PID with a physical exam, lab tests, and imaging tests. Antibiotics can cure PID. Early treatment is important. Waiting too long increases the risk of infertility. NIH: National Institute of Allergy and Infectious Diseases

MalaCards based summary : Pelvic Inflammatory Disease, also known as pid, is related to salpingitis and peritonitis, and has symptoms including pruritus, pelvic pain and fever. An important gene associated with Pelvic Inflammatory Disease is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Iodine and Povidone have been mentioned in the context of this disorder. Affiliated tissues include ovary, uterus and testes, and related phenotypes are cardiovascular system and cellular

CDC : 3 Basic Fact Sheet | Detailed Version

Wikipedia : 72 Pelvic inflammatory disease or pelvic inflammatory disorder (PID) is an infection of the upper part of... more...

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Related Diseases for Pelvic Inflammatory Disease

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Diseases related to Pelvic Inflammatory Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 158)
# Related Disease Score Top Affiliating Genes
1 salpingitis 32.3 CD40LG HSPD1
2 peritonitis 32.1 CCL2 CRP TLR2
3 chlamydia 31.5 CD40LG CRP HSPD1 TLR2 TLR4
4 urethritis 30.0 CD40LG HSPD1 TLR6
5 brucellosis 29.8 CD40LG CRP TLR4
6 mycobacterium tuberculosis 1 29.4 HSPD1 TLR1 TLR2 TLR4
7 pneumonia 29.4 CCL2 CD40LG CRP TLR2 TLR4
8 myocardial infarction 29.3 CCL2 CD40LG CRP MMP9 TLR4
9 fitz-hugh-curtis syndrome 11.4
10 pick disease of brain 10.9
11 benign multicystic peritoneal mesothelioma 10.9
12 diabetic foot ulcers 10.5 CRP MMP9
13 chronic meningitis 10.5 CRP MMP9
14 acalculous cholecystitis 10.5 CD40LG CRP
15 mononeuritis multiplex 10.5 CD40LG CRP
16 ocular toxoplasmosis 10.4 CD40LG TLR1
17 acute maxillary sinusitis 10.4 CD40LG CRP
18 japanese spotted fever 10.4 CD40LG CRP
19 prosthetic joint infection 10.4 TLR2 TLR4
20 dental abscess 10.4 CRP TLR4
21 dressler's syndrome 10.3 CD40LG CRP
22 coccidioidomycosis 10.3 CD40LG TLR4
23 neurosyphilis 10.3 TLR1 TLR2 TLR6
24 takayasu arteritis 10.3 CD40LG CRP MMP9
25 eosinophilic meningitis 10.3 CD40LG MMP9
26 acute cervicitis 10.3 TLR2 TLR4
27 scleritis 10.3 CCL2 MMP9
28 bacterial meningitis 10.3 CRP MMP9 TLR2
29 periodontosis 10.3 CD40LG MMP9 TLR4
30 cat-scratch disease 10.3 CD40LG HSPD1
31 fallopian tube disease 10.3 CD40LG HSPD1
32 pyelitis 10.3 CD40LG CRP TLR4
33 legionnaires' disease 10.2 CD40LG TLR4 TLR6
34 bartonellosis 10.2 CD40LG HSPD1
35 bronchiolitis 10.2 CD40LG TLR1 TLR4
36 periapical periodontitis 10.2 MMP9 TLR2
37 melioidosis 10.2 TLR1 TLR2 TLR4
38 suppurative otitis media 10.2 CRP TLR2 TLR4
39 septic arthritis 10.2 CRP TLR2 TLR4
40 keratitis, hereditary 10.2 MMP9 TLR2 TLR4
41 cervicitis 10.2
42 carotid artery disease 10.2 CCL2 CRP MMP9
43 trench fever 10.2 CD40LG TLR2 TLR4
44 gastrointestinal system disease 10.2 CD40LG CRP TLR4
45 spondylitis 10.2 CD40LG CHI3L1 CRP
46 aortic aneurysm, familial abdominal, 1 10.2 CCL2 CRP MMP9
47 middle ear disease 10.2 CD40LG TLR2 TLR4
48 legionellosis 10.2 CD40LG TLR2 TLR4
49 arteries, anomalies of 10.2 CCL2 CRP MMP9
50 infertility 10.2

Comorbidity relations with Pelvic Inflammatory Disease via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Pelvic Inflammatory Disease:



Diseases related to Pelvic Inflammatory Disease
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Symptoms & Phenotypes for Pelvic Inflammatory Disease

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UMLS symptoms related to Pelvic Inflammatory Disease:


pruritus, pelvic pain, fever

MGI Mouse Phenotypes related to Pelvic Inflammatory Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 MMP9 CD40LG TIRAP CRP TLR2 CTSA
2 cellular MP:0005384 9.97 HSPD1 MMP9 CD40LG CHI3L1 TLR2 CTSA
3 immune system MP:0005387 9.97 CCL2 MMP9 CD40LG TIRAP CHI3L1 TLR1
4 hematopoietic system MP:0005397 9.96 MMP9 CD40LG TIRAP CHI3L1 TLR1 TLR2
5 renal/urinary system MP:0005367 9.5 MMP9 CD40LG TLR2 CTSA TLR4 CTSB
6 reproductive system MP:0005389 9.17 HLA-DQB1 HSPD1 MMP9 CD40LG CTSA TLR4
Sources

Drugs & Therapeutics for Pelvic Inflammatory Disease

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Drugs for Pelvic Inflammatory Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 104)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational Phase 4,Phase 3 7553-56-2 807
2
Povidone Approved Phase 4,Phase 3 9003-39-8
3
Povidone-iodine Approved Phase 4,Phase 3 25655-41-8
4
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
5
Levofloxacin Approved, Investigational Phase 4,Phase 3 100986-85-4 149096
6
Metronidazole Approved Phase 4,Phase 3,Phase 2 443-48-1 4173
7
Ofloxacin Approved Phase 4,Phase 3 82419-36-1 4583
8
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3 50-28-2 5757
9
Ethinyl Estradiol Approved Phase 4,Phase 3 57-63-6 5991
10
Moxifloxacin Approved, Investigational Phase 4,Phase 3 151096-09-2, 354812-41-2 152946
11
Norgestimate Approved, Investigational Phase 4,Phase 3 35189-28-7 6540478
12
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2 564-25-0 54671203
13
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
14
Azithromycin Approved Phase 4,Phase 3 83905-01-5 53477736 447043 55185
15
Cefazolin Approved Phase 4 25953-19-9 33255 656510
16
Copper Approved, Investigational Phase 4 7440-50-8 27099
17 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
18 Anti-Infective Agents, Local Phase 4,Phase 3
19 Blood Substitutes Phase 4,Phase 3
20 cadexomer iodine Phase 4,Phase 3
21 Micronutrients Phase 4,Phase 3
22 Plasma Substitutes Phase 4,Phase 3
23 Trace Elements Phase 4,Phase 3
24 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
25 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
26 Antitubercular Agents Phase 4,Phase 2,Phase 3
27 Clindamycin palmitate Phase 4
28 Clindamycin phosphate Phase 4
29 Gentamicins Phase 4,Phase 2,Phase 3
30 Antiparasitic Agents Phase 4,Phase 3,Phase 2
31 Antiprotozoal Agents Phase 4,Phase 3,Phase 2
32 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3
33 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
34 Renal Agents Phase 4,Phase 3
35 Topoisomerase Inhibitors Phase 4,Phase 3
36 Contraceptive Agents Phase 4,Phase 3
37 Contraceptives, Oral Phase 4,Phase 3
38 Contraceptives, Oral, Combined Phase 4,Phase 3
39 Estradiol 17 beta-cypionate Phase 4,Phase 3
40 Estradiol 3-benzoate Phase 4,Phase 3
41 Estradiol valerate Phase 4,Phase 3 979-32-8
42 Fluoroquinolones Phase 4,Phase 3
43 Norgestimate, ethinyl estradiol drug combination Phase 4,Phase 3
44 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3
45 Polyestradiol phosphate Phase 4,Phase 3
46 Antimalarials Phase 4,Phase 2
47 Pharmaceutical Solutions Phase 4,Phase 3,Phase 1
48
Ampicillin Approved, Vet_approved Phase 2, Phase 3 69-53-4 6249
49
Ceftriaxone Approved Phase 3,Phase 2 73384-59-5 5479530 5361919
50
Epinephrine Approved, Vet_approved Phase 3 51-43-4 5816

Interventional clinical trials:

(show top 50) (show all 76)

# Name Status NCT ID Phase Drugs
1 Preoperative Vaginal Cleansing With Povidone Iodine and the Risk of Post Cesarean Endometritis Unknown status NCT02693483 Phase 4 10% povidone iodine
2 To Compare Ofloxacin With Azitromycin for Pelvic Inflammatory Disease (PID) Treatment Completed NCT01241110 Phase 4 Ofloxacin group A, Azitromycin group B;azitromycin
3 Moxifloxacin Versus Ofloxacin Plus Metronidazole in Uncomplicated Pelvic Inflammatory Disease: Multicenter Randomized Controlled Trials Completed NCT01799356 Phase 4 Moxifloxacin;Ofloxacin;Metronidazole
4 Doxycycline Prophylaxis at Vacuum Aspiration Trial Completed NCT00547170 Phase 4 Doxycycline pre-operatively;Doxycycline post-operatively
5 Does Preoperative Vaginal Preparation With Povidone-iodine Before Cesarean Delivery Reduce the Risk of Endometritis? Completed NCT01437228 Phase 4 povidone- iodine solution.;placebo
6 A Trial to Assess the Efficacy and Safety of Morinidazole in Women With Pelvic Inflammatory Disease Recruiting NCT03391440 Phase 4 morinidazole
7 Antibiotic Prophlaxis for High-risk Laboring Women in Low Income Countries Recruiting NCT03248297 Phase 4 Azithromycin;Azithromycin and amoxicillin;Placebo
8 Comparison Between Intrauterine Contraceptive Device Insertion During Cesarean Section Vs Conventional Application Enrolling by invitation NCT02674139 Phase 4
9 Treatment Utility of Postpartum Antibiotics in Chorioamnionitis Terminated NCT01585129 Phase 4 Postpartum Antibiotics;No postpartum antibiotics
10 Comparison Study of Cefazolin Versus Cefazolin Plus Azithromycin Prophylaxis in Post-Cesarean Endometritis Withdrawn NCT01721616 Phase 4 Azithromycin;Cefazolin
11 A Trial Comparing Moxifloxacin Versus Levofloxacin Plus Metronidazole In Uncomplicated Pelvic Inflammatory Disease Completed NCT00453349 Phase 3 Moxifloxacin (Avelox, BAY12-8039);Levofloxacin & Metronidazole
12 Uncomplicated Pelvic Inflammatory Disease. Treatment With Moxifloxacin. Completed NCT00683865 Phase 3 Ofloxacin;Avelox (Moxifloxacin, BAY12-8039)
13 Study Of Azithromycin Intravenous Formulation Against Pelvic Inflammatory Disease (PID) In Japan Completed NCT00871494 Phase 3 Azithromycin
14 A Phase 3 Study Of Intravenous Metronidazole For Intrabdominal Infection Completed NCT01473836 Phase 3 Metronidazole;Ceftriaxone sodium
15 Home Screening for Chlamydia Surveillance Completed NCT00177437 Phase 3
16 Vasopressin Versus Epinephrine in Myomectomy Completed NCT01861015 Phase 3 Epinephrine;Vasopressin
17 Antibiotic Prophylaxis in Prelabor Rupture of Membranes at Term Completed NCT01633294 Phase 2, Phase 3 Ampicillin + gentamicin
18 Chlorhexidine Gluconate vs Povidone-Iodine Vaginal Cleansing Solution Prior to Cesarean Delivery Recruiting NCT02915289 Phase 3
19 Empiric Therapy of Mucopurulent Cervicitis (MPC) Terminated NCT01072136 Phase 3 Azithromycin;Cefixime
20 The Importance of Anti-anaerobic Therapy for Acute Pelvic Inflammatory Disease (PID) Completed NCT01160640 Phase 2 Ceftriaxone;Doxycycline;Metronidazole;Placebo Oral Capsule
21 An Investigational Agent for the Treatment of Complicated Intra-Abdominal Infections or Acute Pelvic Infections (0826-038) Completed NCT00092170 Phase 2 MK0826, ertapenem sodium;Comparator: Ticarcillin/Clavulanate
22 The Clinical Effect of Fuke Qianjin Capsule on Chronic Pelvic Pain Caused by Pelvic Inflammation Recruiting NCT03251560 Phase 2 Fuke Qianjin capsule;Placebo oral capsule
23 The Efficacy and Safety of the Xue-Fu-Zhu-Yu Capsule in Treatment of Qi Stagnation and Blood Stasis Syndrome. Recruiting NCT03091634 Phase 2 xue-fu-zhu-yu capsule;xue-fu-zhu-yu capsule simulated agent
24 Clinical Research of TCM on Pelvic Inflammatory Disease Sequelae Not yet recruiting NCT02972151 Phase 2 Comprehensive treatment of TCM
25 The Optimal Time for Intravenous Antibiotic Prophylaxis in Elective Cesarean Section Not yet recruiting NCT02742948 Phase 2 ceftriaxone
26 Ultrasound-guided Hydrosalpinx Aspiration During Egg Collection Terminated NCT00566956 Phase 2
27 First in Human Study to Investigate the Safety, Tolerability, Pharmacokinetics and to Explore Pharmacodynamics of BAY1834845 Active, not recruiting NCT03054402 Phase 1 BAY1834845;Placebo
28 Pharmacokinetics and Safety of Ertapenem in the Postpartum Period Terminated NCT01587495 Phase 1 Ertapenem
29 Technology Enhanced Community Health Nursing (TECH-N) Study Unknown status NCT01640379
30 Prophylactic Antibiotics for Manual Removal of Retained Placenta in Vaginal Birth: a Randomized Controlled Trial Unknown status NCT01945450 Antibiotic prophylaxis;Ampicillin;Gentamycin;Clindamycin
31 Rate of Pelvic Inflammatory Disease at St. Michael's Hospital Completed NCT00783419
32 Community-Based Trial of Screening for Chlamydia Trachomatis to Prevent Pelvic Inflammatory Disease Completed NCT00115388
33 Improving Primary Care Follow-up for Patients With Pelvic Inflammatory Disease Completed NCT01299259
34 Drug Use Investigation Of Azithromycin IV For Pneumonia Or Pelvic Inflammatory Disease (Regulatory Post Marketing Commitment Plan) Completed NCT01671280 Azithromycin IV
35 The Role of Novel Organisms in Acute Endometritis Completed NCT01236131
36 To Compare the Strategies of Universal Antibiotic Prophylaxis Versus Screen-and-treat in Reducing Infective Complications and Re-infection in Women Who Undergo Termination of Pregnancy Completed NCT01842100 Universal antibiotic prophylaxis
37 Immunopathogenesis of Chlamydia Completed NCT00607659
38 Complement Diagnosis of Acute Appendicitis Completed NCT03450642
39 Risk of Acute Liver Injury in Users of Antimicrobials Completed NCT01434173 Moxifloxacin (Avelox, BAY12-8039);Amoxicillin, Amoxicillin plus clavulanic acid, Cefuroxime, Clarithromycin, Doxycycline, Levofloxacin, Telithromycin
40 Recurrent Bacterial Vaginosis and Vaginal Acidifying Gel Trial Completed NCT00545181 Vaginal acidifying gel (RepHresh);Metronidazole control
41 Home Sampling Versus Conventional Sampling for Screening of Urogenital Chlamydia Trachomatis in Young Men and Women. Completed NCT00283127
42 A Comparison of Narrow Band Imaging (NBI) and Standard White Light Laporoscopy to Detect Endometriosis Completed NCT01464775
43 Longitudinal Study of Vaginal Flora Completed NCT00340275
44 Mirena Post-marketing Surveillance in Japan Completed NCT01414140 Levonorgestrel IUS (Mirena, BAY86-5028)
45 Minimal Invasive Strategies for Good and Complete Response to Chemoradiation in Rectal Cancer Completed NCT00939666
46 Special Investigation Of Azithromycin IV For Legionnaires' Disease (Regulatory Post Marketing Commitment Plan) Completed NCT01784770 Azithromycin IV
47 Quick Start Insertion of Mirena and ParaGard Completed NCT01730911
48 Surgical Success After Laparoscopic vs Abdominal Hysterectomy Completed NCT01793584
49 Bacterial Vaginosis Screening at IUD Insertion Completed NCT00802386
50 Efficacy of Dead Sea Peloid Gel in Chronic Endometritis Completed NCT02680275 Dead Sea Peloid Gel

Search NIH Clinical Center for Pelvic Inflammatory Disease

Cochrane evidence based reviews: pelvic inflammatory disease

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Genetic Tests for Pelvic Inflammatory Disease

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Anatomical Context for Pelvic Inflammatory Disease

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MalaCards organs/tissues related to Pelvic Inflammatory Disease:

38
Ovary, Uterus, Testes, Liver, Placenta, Neutrophil, Breast
Sources

Publications for Pelvic Inflammatory Disease

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Articles related to Pelvic Inflammatory Disease:

(show top 50) (show all 626)
# Title Authors Year
1
The effect of antibiotic prophylaxis for acute pelvic inflammatory disease after hysterosalpingography: a retrospective cohort study. ( 29239678 )
2018
2
Trends in pelvic inflammatory disease emergency department visits, United States, 2006-2013. ( 29045851 )
2018
3
Pelvic inflammatory disease risk following negative results from chlamydia nucleic acid amplification tests (NAATs) versus non-NAATs in Denmark: A retrospective cohort. ( 29293503 )
2018
4
Predictive factors for emergent surgical intervention in patients with ovarian endometrioma hospitalized for pelvic inflammatory disease: A retrospective observational study. ( 29171117 )
2018
5
Toll-like receptor variants and cervical Atopobium vaginae infection in women with pelvic inflammatory disease. ( 29286178 )
2018
6
2017 European guideline for the management of pelvic inflammatory disease. ( 29198181 )
2018
7
Risk of Pelvic Inflammatory Disease in Relation to Chlamydia and Gonorrhea Testing, Repeat Testing, and Positivity: A Population-Based Cohort Study. ( 29136127 )
2018
8
Risk of pelvic inflammatory disease after intrauterine insemination: a systematic review. ( 29287941 )
2018
9
Sustained Simultaneous Delivery of Metronidazole and Doxycycline From Polycaprolactone Matrices Designed for Intravaginal Treatment of Pelvic Inflammatory Disease. ( 29100864 )
2018
10
Impact of the Levonorgestrel-Releasing Intrauterine System on the Progression of Chlamydia trachomatis Infection to Pelvic Inflammatory Disease in a Baboon Model. ( 29253201 )
2018
11
Microbiota changes impact on sexually transmitted infections and the development of pelvic inflammatory disease. ( 29452257 )
2018
12
Mesenchymal Stem Cells in Restoration of Fertility at Experimental Pelvic Inflammatory Disease. ( 28928773 )
2017
13
Anti-inflammatory Effects of the Natural Compounds Cortex Phellodendri and Humulus japonicus on Pelvic Inflammatory Disease in Mice. ( 28824307 )
2017
14
Prevalence of Pelvic Inflammatory Disease in Sexually Experienced Women of Reproductive Age - United States, 2013-2014. ( 28125569 )
2017
15
Socioeconomic status of parents and the occurrence of pelvic inflammatory disease among undergraduates attending Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria. ( 28762367 )
2017
16
Pelvic Inflammatory Disease and the Risk of Ovarian Cancer and Borderline Ovarian Tumors: A Pooled Analysis of 13 Case-Control Studies. ( 27941069 )
2017
17
Evaluation of pelvic inflammatory disease potential in cholinesterase inhibitor pesticide-exposed females. ( 28497326 )
2017
18
What Antibiotic Regimen Is Most Efficacious in Treating Pelvic Inflammatory Disease? ( 28822590 )
2017
19
Curative effect of Jin'gangteng capsule combined with Kangfuxiaoyan suppository in the treatment of chronic pelvic inflammatory disease. ( 29105625 )
2017
20
Pelvic inflammatory disease and the risk of ovarian cancer: a meta-analysis. ( 28342087 )
2017
21
Severe Sepsis and Acute Myocardial Dysfunction in an Adolescent with Chlamydia Trachomatis Pelvic Inflammatory Disease: A Case Report. ( 29037929 )
2017
22
A Community Based Study on Pelvic Inflammatory Disease in Postmenopausal Females: Microbiological Spectrum and Socio-Demographic Correlates. ( 28511414 )
2017
23
Erroneously Suspected Ovarian Cancer in a 38-Year-Old Woman with Pelvic Inflammatory Disease and Chlamydia. ( 29391959 )
2017
24
How to differentiate acute pelvic inflammatory disease from acute appendicitis ? A decision tree based on CT findings. ( 28894927 )
2017
25
The potential role of infectious agents and pelvic inflammatory disease in ovarian carcinogenesis. ( 28529540 )
2017
26
Postpartum tubo-ovarian abscess, likely arising from pelvic inflammatory disease during pregnancy. ( 28408537 )
2017
27
Clinical characteristics of genital chlamydia infection in pelvic inflammatory disease. ( 28086838 )
2017
28
Pelvic inflammatory disease due to Streptococcus pneumoniae. ( 28807391 )
2017
29
Pelvic inflammatory disease. ( 28098673 )
2017
30
Pelvic Inflammatory Disease in a Pediatric Emergency Department: Epidemiology and Treatment. ( 28441241 )
2017
31
Antibiotic therapy for pelvic inflammatory disease. ( 28436019 )
2017
32
Efficacy and safety of morinidazole in pelvic inflammatory disease: results of a multicenter, double-blind, randomized trial. ( 28265816 )
2017
33
Is Pelvic Inflammatory Disease a Risk Factor for Ovarian Cancer? ( 27672055 )
2017
34
Comparison of the population excess fraction of Chlamydia trachomatis infection on pelvic inflammatory disease at 12-months in the presence and absence of chlamydia testing and treatment: Systematic review and retrospective cohort analysis. ( 28199392 )
2017
35
Whole-Exome Sequencing to Identify Novel Biological Pathways Associated With Infertility After Pelvic Inflammatory Disease. ( 27898568 )
2017
36
Early screening for Chlamydia trachomatis in young women for primary prevention of pelvic inflammatory disease (i-Predict): study protocol for a randomised controlled trial. ( 29132441 )
2017
37
Pelvic inflammatory disease and salpingitis: incidence of primary and repeat episodes in England. ( 27678278 )
2017
38
Current perspectives in the USA on the diagnosis and treatment of pelvic inflammatory disease in adolescents. ( 28721112 )
2017
39
Usefulness of Serum Procalcitonin Levels in Predicting Tubo-Ovarian Abscess in Patients with Acute Pelvic Inflammatory Disease. ( 27592364 )
2016
40
Identification of novel microbes associated with pelvic inflammatory disease and infertility. ( 26825087 )
2016
41
MRI in pelvic inflammatory disease: a pictorial review. ( 27933478 )
2016
42
Proportion of Pelvic Inflammatory Disease Cases Caused by Chlamydia trachomatis: Consistent Picture From Different Methods. ( 27260786 )
2016
43
Fitz-Hugh-Curtis syndrome lacking typical characteristics of pelvic inflammatory disease. ( 27335367 )
2016
44
Updated French guidelines for diagnosis and management of pelvic inflammatory disease. ( 27170602 )
2016
45
Disseminated histoplasmosis presenting as pelvic inflammatory disease. ( 26783441 )
2016
46
Risk of psychiatric disorders following pelvic inflammatory disease: a nationwide population-based retrospective cohort study. ( 26821967 )
2016
47
Pelvic inflammatory disease increases the risk of a second primary malignancy in patients with cervical cancer treated by surgery alone. ( 27893679 )
2016
48
Pelvic inflammatory disease. ( 27107781 )
2016
49
Reproductive outcomes of patients being hospitalised with pelvic inflammatory disease. ( 27750467 )
2016
50
Increased risk of borderline ovarian tumors in women with a history of pelvic inflammatory disease: A nationwide population-based cohort study. ( 27549433 )
2016
Sources

Variations for Pelvic Inflammatory Disease

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Expression for Pelvic Inflammatory Disease

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Search GEO for disease gene expression data for Pelvic Inflammatory Disease.
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Pathways for Pelvic Inflammatory Disease

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Pathways related to Pelvic Inflammatory Disease according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 62
Show member pathways
 13.56 CCL2 CD40LG CHI3L1 CRP CTSA CTSB
2
Akt Signaling 60
Show member pathways
 13.32 CCL2 CD40LG TIRAP TLR1 TLR2 TLR4
3
Class I MHC mediated antigen processing and presentation 62
Show member pathways
 13.29 CD40LG CTSA CTSB HLA-DQB1 TIRAP TLR1
4
Toll-Like receptor Signaling Pathways 61
Show member pathways
 12.86 CCL2 CTSB TIRAP TLR1 TLR2 TLR4
5
NF-KappaB Family Pathway 60
Show member pathways
 12.62 CD40LG TLR1 TLR2 TLR4 TLR6
6
TRAF Pathway 60
Show member pathways
 12.53 CD40LG TIRAP TLR1 TLR2 TLR4 TLR6
7
NF-kappaB Signaling 4
12.5 CCL2 CD40LG TLR1 TLR2 TLR6
8
Kaposi's sarcoma-associated herpesvirus infection 36
Show member pathways
 12.47 MMP9 TIRAP TLR2 TLR4
9
Antigen processing-Cross presentation 62
Show member pathways
 12.42 TIRAP TLR1 TLR2 TLR4 TLR6
10
Toll-like receptor signaling pathway 1 36
Show member pathways
 12.37 CCL2 TIRAP TLR1 TLR2 TLR4 TLR6
11
Toxoplasmosis 36
Show member pathways
 12.19 CD40LG HLA-DQB1 TLR2 TLR4
12
Diseases associated with the TLR signaling cascade 62
Show member pathways
 12.19 TIRAP TLR1 TLR2 TLR4 TLR6
13
Colorectal Cancer Metastasis 60
12.09 MMP9 TLR1 TLR2 TLR4 TLR6
14
Phagosome 36
12.08 HLA-DQB1 TLR2 TLR4 TLR6
15
MAPK Pathway 68
Show member pathways
 11.98 TLR1 TLR2 TLR4 TLR6
16
Spinal Cord Injury 1
11.91 CCL2 MMP9 TLR4
17
IL27-mediated signaling events 1
Show member pathways
 11.89 TLR1 TLR2 TLR4 TLR6
18
p53 Pathway (RnD) 61
11.89 CCL2 TLR1 TLR2 TLR4 TLR6
19
MHC class II antigen presentation 62
11.83 CTSA CTSB HLA-DQB1
20
Th17 Differentiation Pathway 61
Show member pathways
 11.82 TLR1 TLR2 TLR4 TLR6
21
Rheumatoid arthritis 36
11.8 CCL2 HLA-DQB1 TLR2 TLR4
22
NF-kappa B signaling pathway 36
11.79 CD40LG TIRAP TLR4
23
Phagocytosis of Microbes 60
11.77 TLR1 TLR2 TLR4 TLR6
24
Bacterial infections in CF airways 21
Show member pathways
 11.65 CTSB TIRAP TLR1 TLR2 TLR4 TLR6
25
IgA-Producing B Cells in the Intestine 61
11.63 CD40LG TLR2 TLR4
26
Legionellosis 36
11.54 HSPD1 TLR2 TLR4
27
MSP-RON Signaling 60
11.47 CCL2 TLR2 TLR4
28
Malaria 36
11.42 CCL2 CD40LG TLR2 TLR4
29
Tuberculosis 36
11.42 HLA-DQB1 HSPD1 TIRAP TLR1 TLR2 TLR4
30
A-beta Pathways: Uptake and Degradation 61
11.13 CCL2 CD40LG MMP9 TLR4
31
A-beta Pathways: Plaque Formation and APP Metabolism 61
11.02 CTSB MMP9
32
IL1 and megakaryocytes in obesity 1
10.96 CCL2 MMP9 TLR1 TLR2
Sources

GO Terms for Pelvic Inflammatory Disease

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Cellular components related to Pelvic Inflammatory Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 CCL2 CD40LG CHI3L1 CRP CTSB HSPD1
2 phagocytic vesicle membrane GO:0030670 9.33 TLR1 TLR2 TLR6
3 lipopolysaccharide receptor complex GO:0046696 8.96 HSPD1 TLR4
4 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.62 TLR1 TLR2

Biological processes related to Pelvic Inflammatory Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.96 CCL2 CHI3L1 TIRAP TLR4
2 immune response GO:0006955 9.95 CCL2 CD40LG HLA-DQB1 TLR1 TLR2 TLR4
3 defense response to Gram-positive bacterium GO:0050830 9.86 CRP TIRAP TLR2
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 CD40LG TIRAP TLR2 TLR4 TLR6
5 positive regulation of tumor necrosis factor production GO:0032760 9.82 TIRAP TLR2 TLR4
6 positive regulation of interleukin-6 production GO:0032755 9.81 HSPD1 TLR2 TLR4
7 lipopolysaccharide-mediated signaling pathway GO:0031663 9.76 CCL2 TLR2 TLR4
8 positive regulation of interleukin-8 production GO:0032757 9.72 TIRAP TLR2 TLR4
9 positive regulation of interferon-beta production GO:0032728 9.71 TLR2 TLR4
10 positive regulation of T cell activation GO:0050870 9.71 CCL2 HSPD1
11 positive regulation of NF-kappaB import into nucleus GO:0042346 9.71 TLR2 TLR4
12 activation of NF-kappaB-inducing kinase activity GO:0007250 9.71 CHI3L1 TIRAP TLR6
13 positive regulation of chemokine production GO:0032722 9.7 TLR2 TLR4
14 toll-like receptor 4 signaling pathway GO:0034142 9.7 TIRAP TLR4
15 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.7 TLR4 TLR6
16 positive regulation of macrophage activation GO:0043032 9.7 HSPD1 TLR4 TLR6
17 microglial cell activation GO:0001774 9.69 TLR2 TLR6
18 positive regulation of interleukin-8 secretion GO:2000484 9.69 TLR1 TLR2
19 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.69 TLR4 TLR6
20 cell activation GO:0001775 9.69 TLR1 TLR2 TLR6
21 I-kappaB phosphorylation GO:0007252 9.68 TLR2 TLR4
22 positive regulation of interferon-alpha production GO:0032727 9.68 HSPD1 TLR4
23 T-helper 1 type immune response GO:0042088 9.68 TLR4 TLR6
24 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.67 TLR1 TLR4
25 macrophage activation GO:0042116 9.67 TLR1 TLR4
26 interleukin-1 beta secretion GO:0050702 9.67 TLR4 TLR6
27 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.67 CCL2 TLR2 TLR4
28 positive regulation of interleukin-10 production GO:0032733 9.67 CD40LG HSPD1 TLR2 TLR4
29 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.65 TLR4 TLR6
30 positive regulation of NLRP3 inflammasome complex assembly GO:1900227 9.65 TLR4 TLR6
31 cellular response to lipoteichoic acid GO:0071223 9.65 TIRAP TLR2 TLR4
32 toll-like receptor signaling pathway GO:0002224 9.65 CTSB TLR1 TLR2 TLR4 TLR6
33 positive regulation of toll-like receptor 2 signaling pathway GO:0034137 9.63 TIRAP TLR1
34 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.63 TLR2 TLR6
35 cellular response to diacyl bacterial lipopeptide GO:0071726 9.62 TLR2 TLR6
36 cellular response to bacterial lipopeptide GO:0071221 9.62 TIRAP TLR2
37 regulation of cytokine secretion GO:0050707 9.62 TLR1 TLR2 TLR4 TLR6
38 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.61 TLR1 TLR2
39 cellular response to triacyl bacterial lipopeptide GO:0071727 9.61 TLR1 TLR2
40 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.61 TIRAP TLR1 TLR6
41 inflammatory response GO:0006954 9.61 CCL2 CD40LG CHI3L1 CRP TIRAP TLR1
42 nitric oxide metabolic process GO:0046209 9.6 TLR2 TLR6
43 positive regulation of oxidative stress-induced neuron death GO:1903223 9.59 TLR4 TLR6
44 detection of triacyl bacterial lipopeptide GO:0042495 9.58 TLR1 TLR2
45 detection of diacyl bacterial lipopeptide GO:0042496 9.57 TLR2 TLR6
46 response to bacterial lipoprotein GO:0032493 9.56 TLR2 TLR6
47 positive regulation of interleukin-12 production GO:0032735 9.55 CD40LG HSPD1 TIRAP TLR2 TLR4
48 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.1 HSPD1 TIRAP TLR1 TLR2 TLR4 TLR6
49 innate immune response GO:0045087 10.06 TIRAP TLR1 TLR2 TLR4 TLR6
50 neutrophil degranulation GO:0043312 10.06 CHI3L1 CTSA CTSB MMP9 TLR2

Molecular functions related to Pelvic Inflammatory Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.77 TIRAP TLR1 TLR2 TLR4 TLR6
2 receptor activity GO:0004872 9.62 TLR1 TLR2 TLR4 TLR6
3 lipopolysaccharide binding GO:0001530 9.33 HSPD1 TLR2 TLR4
4 lipopolysaccharide receptor activity GO:0001875 9.26 TLR2 TLR4
5 lipopeptide binding GO:0071723 9.13 TLR1 TLR2 TLR6
6 Toll-like receptor 2 binding GO:0035663 8.8 TIRAP TLR1 TLR6
Sources

Sources for Pelvic Inflammatory Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
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The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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