PID
MCID: PLV003
MIFTS: 56

Pelvic Inflammatory Disease (PID) malady

Reproductive diseases category

Summaries for Pelvic Inflammatory Disease

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33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Pelvic inflammatory disease (pid) is an infection and inflammation of the uterus, ovaries, and other female reproductive organs. it causes scarring in these organs. this can lead to infertility, ectopic pregnancy, pelvic pain, abscesses, and other serious problems. pid is the most common preventable cause of infertility in the united states. gonorrhea and chlamydia, two sexually transmitted diseases, are the most common causes of pid. other bacteria can also cause it. you are at greater risk if you are sexually active and younger than 25 have more than one sex partner douche some women have no symptoms. others have pain in the lower abdomen, fever, smelly vaginal discharge, irregular bleeding, and pain during intercourse or urination. doctors diagnose pid with a physical exam, lab tests, and imaging tests. antibiotics can cure pid. early treatment is important. waiting too long increases the risk of infertility. nih: national institute of allergy and infectious diseases

MalaCards: Pelvic Inflammatory Disease, also known as inflammatory disease of female pelvic organs and/or tissues, is related to cervicitis and endometriosis. An important gene associated with Pelvic Inflammatory Disease is HSPD1 (heat shock 60kDa protein 1 (chaperonin)), and among its related pathways are MHC class II antigen presentation and Immune response Bacterial infections in normal airways. The compounds cycloheximide and ninhydrin have been mentioned in the context of this disorder. Affiliated tissues include ovary, uterus and testes, and related mouse phenotypes are hematopoietic system and renal/urinary system.

CDC:3 Basic Fact Sheet | Detailed Version

Wikipedia:63 Pelvic inflammatory disease (or disorder) (PID) is a term for inflammation of the uterus, fallopian... more...

Aliases & Classifications for Pelvic Inflammatory Disease

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt, 25ICD10
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Related Diseases for Pelvic Inflammatory Disease

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Pelvic Inflammatory Disease:



Diseases related to pelvic inflammatory disease

Clinical Features for Pelvic Inflammatory Disease

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Drugs & Therapeutics for Pelvic Inflammatory Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Pelvic Inflammatory Disease

Search CenterWatch for Pelvic Inflammatory Disease

Genetic Tests for Pelvic Inflammatory Disease

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Anatomical Context for Pelvic Inflammatory Disease

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32MalaCards
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MalaCards organs/tissues related to Pelvic Inflammatory Disease:

32
Ovary, Uterus, Testes, Colon, Breast, Skin, Monocytes, T cells

Animal Models for Pelvic Inflammatory Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pelvic Inflammatory Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.3TLR4, CTSA, GUSB, HLA-DQA1, CHI3L1, CYP11B1
2MP:00053679.2LCN2, TLR4, CTSA, CTSB, GUSB, CYP11B1
3MP:00053879.0PLAU, LCN2, TLR4, TLR1, CTSA, CTSB

Publications for Pelvic Inflammatory Disease

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50PubMed
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Articles related to Pelvic Inflammatory Disease:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
Controversies in family planning: postabortal pelvic inflammatory disease. (22652188)
2013
2
Significantly increased concentration of soluble urokinase-type plasminogen activator receptor in the blood of patients with pelvic inflammatory disease. (23117033)
2013
3
Status of adolescent pelvic inflammatory disease management in the United States. (24018871)
2013
4
Pelvic inflammatory disease. (22534389)
2012
5
Pathogenesis, diagnosis, and management of severe pelvic inflammatory disease and tuboovarian abscess. (23090458)
2012
6
Improving adherence to guidelines for the diagnosis and management of pelvic inflammatory disease: a systematic review. (22973085)
2012
7
Difficulties experienced in defining the microbial cause of pelvic inflammatory disease. (22362682)
2012
8
Estimating the direct costs of pelvic inflammatory disease in adolescents: a within-system analysis. (21057380)
2011
9
Microbial correlates of delayed care for pelvic inflammatory disease. (21124257)
2011
10
Quality of care for pelvic inflammatory disease: room for improvement. (23330151)
2011
11
Recommendations and rationale for the treatment of pelvic inflammatory disease. (21171878)
2011
12
Results of a randomized controlled trial of a brief behavioral intervention for pelvic inflammatory disease in adolescents. (19733100)
2010
13
Ectopic pregnancy and pelvic inflammatory disease: a renewed epidemic? (20472335)
2010
14
Current concepts in managing pelvic inflammatory disease. (19935421)
2010
15
Uterine cervical non-gonococcal and non-chlamydial bacterial flora and its antibiotic sensitivity in women with pelvic inflammatory disease: did it vary over 20 years? (21348403)
2010
16
Sexually transmitted infections and pelvic inflammatory disease in women. (18721654)
2008
17
Clinical prediction rule to distinguish pelvic inflammatory disease from acute appendicitis in women of childbearing age. (17276803)
2007
18
Moxifloxacin versus ofloxacin plus metronidazole in uncomplicated pelvic inflammatory disease: results of a multicentre, double blind, randomised trial. (16723364)
2006
19
Use of pH/whiff test or QuickVue Advanced pH and Amines test for the diagnosis of bacterial vaginosis and prevention of postabortion pelvic inflammatory disease. (16817083)
2006
20
Use of an institutional intervention to improve quality of care for adolescents treated in pediatric ambulatory settings for pelvic inflammatory disease. (16781961)
2006
21
Staphylococcus sciuri: an unusual cause of pelvic inflammatory disease. (15969784)
2005
22
Effectiveness of treatment strategies of some women with pelvic inflammatory disease: a randomized trial. (16135590)
2005
23
Pelvic inflammatory disease. (15652102)
2004
24
Pelvic inflammatory disease in adolescents. (15449845)
2004
25
Ultrasound of pelvic inflammatory disease. (15602219)
2004
26
Associations among human leukocyte antigen (HLA) class II DQ variants, bacterial sexually transmitted diseases, endometritis, and fertility among women with clinical pelvic inflammatory disease. (15107633)
2004
27
Measurement of IgG antibodies to Chlamydia trachomatis by commercial enzyme immunoassays and immunofluorescence in sera from pregnant women and patients with infertility, pelvic inflammatory disease, ectopic pregnancy, and laboratory diagnosed Chlamydia psittaci/Chlamydia pneumoniae infection. (12610104)
2003
28
Associations between Mycoplasma genitalium, Chlamydia trachomatis and pelvic inflammatory disease. (12890814)
2003
29
Outpatient antibiotics for pelvic inflammatory disease. (11157512)
2001
30
Epidemiology of ectopic pregnancy during a 28 year period and the role of pelvic inflammatory disease. (10817065)
2000
31
Three years of a clinical practice guideline for uncomplicated pelvic inflammatory disease in adolescents. (10867353)
2000
32
Relationship between use of the intrauterine device and pelvic inflammatory disease. (10333811)
1999
33
MR imaging in pelvic inflammatory disease: comparison with laparoscopy and US. (9885610)
1999
34
Pelvic inflammatory disease in adolescents. (10494256)
1999
35
Severity of pelvic inflammatory disease as a predictor of the probability of live birth. (9609570)
1998
36
High quality, cost-effective care for adolescents with pelvic inflammatory disease. (9806132)
1998
37
Programmes to reduce pelvic inflammatory disease--the Swedish experience. (9652718)
1998
38
Adolescent girls and pelvic inflammatory disease: experience and practices of emergency department pediatricians. (9605027)
1998
39
Pelvic inflammatory disease in women infected with HIV. (11361990)
1998
40
Prevalence and correlates of antibody to chlamydial heat shock protein in women attending sexually transmitted disease clinics and women with confirmed pelvic inflammatory disease. (9180186)
1997
41
Pelvic inflammatory disease: a review. (11364742)
1997
42
Pelvic inflammatory disease isolates of Neisseria gonorrhoeae are distinguished by C1q-dependent virulence for newborn rats and by the sac-4 region. (9169737)
1997
43
Hormonal contraception and pelvic inflammatory disease. (9678084)
1997
44
Trospectomycin in acute pelvic inflammatory disease: a preliminary report. (18476139)
1997
45
Partner notification to prevent pelvic inflammatory disease in women. Cost-effectiveness of two strategies. (9153739)
1997
46
Lethal outcome of pelvic inflammatory disease in five women who were seropositive for HIV. (8679767)
1996
47
Risk factors for Chlamydia trachomatis pelvic inflammatory disease among sex workers in Nairobi, Kenya. (8648217)
1996
48
The relationship of vaginal trichomoniasis and pelvic inflammatory disease among women colonized with Chlamydia trachomatis. (8578405)
1995
49
Randomized comparison of ampicillin-sulbactam to cefoxitin and doxycycline or clindamycin and gentamicin in the treatment of pelvic inflammatory disease or endometritis. (8190448)
1994
50
Frequency and distribution of salpingitis and pelvic inflammatory disease in short-stay hospitals in the United States. (7468679)
1980

Genetic Variations for Pelvic Inflammatory Disease

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Expression for genes affiliated with Pelvic Inflammatory Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pelvic Inflammatory Disease

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Pathways for genes affiliated with Pelvic Inflammatory Disease

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53Reactome, 29KEGG
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Compounds for genes affiliated with Pelvic Inflammatory Disease

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 2BitterDB
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Compounds related to Pelvic Inflammatory Disease according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.6HSPD1
2ninhydrin4410.6CTSB, CTSA
3bifidobacterium4410.5GUSB, HSPD1
4pam2csk45910.5TLR4, TLR1
5pam3csk45910.5TLR4, TLR1
6poly(i:c)5910.5TLR4, TLR1
7aspartate4410.5GUSB, CST3, HSPD1
8flagellin44 2811.5HSPD1, TLR4, TLR1
9actinidin4410.4CST3, CTSB
10resiquimod44 5911.4TLR1, TLR4
11leupeptin4410.4PLAU, CTSB, CST3
12dexamethasone44 49 28 1113.4TLR4, CYP11B1, CLEC3B
13doxycycline44 1111.3LACTB, PLAU, HSPD1
14guanidine hydrochloride4410.3PLAU, CTSB, HSPD1
15mannose 6-phosphate44 2411.3CTSA, CTSB, GUSB, PLAU
16Alpha-D-Mannose1110.3LCN2, GUSB, CHI3L1, MAN1B1
17vancomycin44 1111.3CST3, LACTB
18e 64d44 5911.3CTSB, CTSA
19kininogen4410.2PLAU, CLEC3B, CTSB, CST3
20gold4410.2HSPD1, LCN2, CST3, CTSB
21aprotinin44 1111.2PLAU, CTSB, CST3
22chloroquine44 2 49 28 1114.1PLAU, CTSB, TLR4
23glutamine4410.1HSPD1, CST3, CTSB, CYP11B1, PLAU
24fmlp4410.1CLEC3B, GUSB, TLR4, LCN2
25n acetylcysteine4410.1HSPD1, TLR4, CST3, PLAU
26latex4410.1CST3, TLR4, HSPD1
27cisplatin44 49 59 1113.1HSPD1, TLR4, CST3, CTSB, PLAU
28superoxide44 2411.0HSPD1, LCN2, TLR4, CST3, GUSB
29iron44 2411.0HSPD1, LCN2, TLR4, CST3, CTSB
30lactate4410.0HSPD1, TLR4, CST3, CTSB, GUSB, PLAU
31creatinine4410.0HSPD1, LCN2, CST3, CTSB, GUSB, PLAU
32fibrinogen449.9HSPD1, LCN2, TLR4, CST3, CTSB, PLAU
33doxorubicin44 49 1111.9PLAU, GUSB, CTSB, HSPD1
34polysaccharide449.9HSPD1, LCN2, TLR4, CST3, CLEC3B, PLAU
35alanine449.9HSPD1, TLR4, CST3, CTSB, CYP11B1, PLAU
36serine449.7LACTB, CTSB, TLR4
37cholesterol44 28 11 2412.7HSPD1, TLR4, CST3, CTSB, CYP11B1
38calcium44 49 11 2412.3HSPD1, LCN2, TLR4, CST3, CTSB, GUSB

GO Terms for genes affiliated with Pelvic Inflammatory Disease

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16Gene Ontology
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Cellular components related to Pelvic Inflammatory Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor complexGO:0466969.9HSPD1, TLR4
2mitochondrionGO:0057399.6LACTB, CYP11B1, MFN2, CTSB, CTSA, HSPD1
3extracellular spaceGO:0056159.3PLAU, CLEC3B, CHI3L1, CTSB, CST3, LCN2

Biological processes related to Pelvic Inflammatory Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1regulation of cytokine secretionGO:05070710.4TLR1, TLR4
2macrophage activationGO:04211610.3TLR1, TLR4
3positive regulation of tumor necrosis factor biosynthetic processGO:04253510.3TLR1, TLR4
4positive regulation of interferon-alpha productionGO:03272710.2HSPD1, TLR4
5MyD88-dependent toll-like receptor signaling pathwayGO:00275510.2HSPD1, TLR4, TLR1
6T-helper 1 type immune responseGO:04208810.1TLR1, TLR4
7immune responseGO:0069559.9CYP11B1, HLA-DQA1, TLR1, TLR4
8positive regulation of interleukin-10 productionGO:0327339.9TLR4, HSPD1

Molecular functions related to Pelvic Inflammatory Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide bindingGO:00153010.2TLR4, HSPD1

Products for genes affiliated with Pelvic Inflammatory Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pelvic Inflammatory Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet