PID
MCID: PLV003
MIFTS: 48

Pelvic Inflammatory Disease (PID) malady

Reproductive category

Summaries for Pelvic Inflammatory Disease

Sources:
34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Pelvic inflammatory disease (pid) is an infection and inflammation of the uterus, ovaries, and other female reproductive organs. it causes scarring in these organs. this can lead to infertility, ectopic pregnancy, pelvic pain, abscesses, and other serious problems. pid is the most common preventable cause of infertility in the united states. gonorrhea and chlamydia, two sexually transmitted diseases, are the most common causes of pid. other bacteria can also cause it. you are at greater risk if you are sexually active and younger than 25 have more than one sex partner douche some women have no symptoms. others have pain in the lower abdomen, fever, smelly vaginal discharge, irregular bleeding, and pain during intercourse or urination. doctors diagnose pid with a physical exam, lab tests, and imaging tests. antibiotics can cure pid. early treatment is important. waiting too long increases the risk of infertility. nih: national institute of allergy and infectious diseases

MalaCards: Pelvic Inflammatory Disease, also known as inflammatory disease of female pelvic organs and/or tissues, is related to appendicitis and sepsis. An important gene associated with Pelvic Inflammatory Disease is HSPD1 (heat shock 60kDa protein 1 (chaperonin)), and among its related pathways are MHC class II antigen presentation and TRAF6 Mediated Induction of proinflammatory cytokines. The compounds cycloheximide and ninhydrin have been mentioned in the context of this disorder. Related mouse phenotypes are hematopoietic system and renal/urinary system.

CDC:3 Pelvic inflammatory disease (PID) refers to infection of the uterus (womb), fallopian tubes (tubes that carry eggs from the ovaries to the uterus) and other reproductive organs that causes symptoms such as lower abdominal pain. It is a serious complication of some sexually transmitted diseases (STDs), especially chlamydia and gonorrhea. PID can damage the fallopian tubes and tissues in and near the uterus and ovaries. PID can lead to serious consequences including infertility, ectopic pregnancy (a pregnancy in the fallopian tube or elsewhere outside of the womb), abscess formation, and chronic pelvic pain.

Wikipedia:64 Pelvic inflammatory disease (or disorder) (PID) is a term for inflammation of the uterus, fallopian... more...

Aliases & Classifications for Pelvic Inflammatory Disease

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt, 25ICD10
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Related Diseases for Pelvic Inflammatory Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Pelvic Inflammatory Disease:



Diseases related to pelvic inflammatory disease

Clinical Features for Pelvic Inflammatory Disease

Drugs & Therapeutics for Pelvic Inflammatory Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Pelvic Inflammatory Disease

Drug clinical trials:

Search ClinicalTrials for Pelvic Inflammatory Disease

Search NIH Clinical Center for Pelvic Inflammatory Disease

Search CenterWatch for Pelvic Inflammatory Disease

Genetic Tests for Pelvic Inflammatory Disease

Anatomical Context for Pelvic Inflammatory Disease

Animal Models for Pelvic Inflammatory Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Pelvic Inflammatory Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.3CTSA, TLR4, LCN2, GUSB, HLA-DQA1, CYP11B1
2MP:00053679.2TLR4, CTSA, CTSB, GUSB, CYP11B1, LCN2
3MP:00053879.0PLAU, LCN2, TLR4, TLR1, CTSA, CTSB

Publications for Pelvic Inflammatory Disease

Sources:
51PubMed
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Articles related to Pelvic Inflammatory Disease:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
Clinician perspectives on management of adolescents with pelvic inflammatory disease using standardized patient scenarios. (23680907)
2013
2
Pelvic inflammatory disease: identifying research gaps--proceedings of a workshop sponsored by Department of Health and Human Services/National Institutes of Health/National Institute of Allergy and Infectious Diseases, November 3-4, 2011. (24275724)
2013
3
Genital tract infection of women in Southern Orissa with special reference to pelvic inflammatory disease. (23919063)
2013
4
Chlamydia public health programs and the epidemiology of pelvic inflammatory disease and ectopic pregnancy. (23100568)
2013
5
Beyond "safe sex"--can we fight adolescent pelvic inflammatory disease? (22777641)
2013
6
Describing the progression from Chlamydia trachomatis and Neisseria gonorrhoeae to pelvic inflammatory disease: systematic review of mathematical modeling studies. (22801346)
2012
7
A national audit on the management of pelvic inflammatory disease in UK genitourinary medicine clinics. (22362690)
2012
8
Laboratory-confirmed gonorrhea and/or chlamydia rates in clinically diagnosed pelvic inflammatory disease and cervicitis. (22030186)
2012
9
Variants in toll-like receptor 1 and 4 genes are associated with Chlamydia trachomatis among women with pelvic inflammatory disease. (22238472)
2012
10
Poor provider adherence to the Centers for Disease Control and Prevention treatment guidelines in US emergency department visits with a diagnosis of pelvic inflammatory disease. (21317690)
2011
11
Relationships between transvaginal colour Doppler findings, infectious parameters and visual analogue scale scores in patients with mild acute pelvic inflammatory disease. (21269753)
2011
12
Pelvic inflammatory disease in the form of peritoneal abscess complicating late pregnancy. (22567518)
2011
13
Association between stroke and patients with pelvic inflammatory disease: a nationwide population-based study in Taiwan. (21566233)
2011
14
A practical approach to the diagnosis of pelvic inflammatory disease. (21822367)
2011
15
Limitations of the criteria used to diagnose histologic endometritis in epidemiologic pelvic inflammatory disease research. (21996319)
2011
16
Management of first-episode pelvic inflammatory disease in primary care: results from a large UK primary care database. (20883614)
2010
17
A comparison of treatment outcomes for moxifloxacin versus ofloxacin/metronidazole for first-line treatment of uncomplicated non-gonococcal pelvic inflammatory disease. (20215625)
2010
18
Efficacy and safety of moxifloxacin in uncomplicated pelvic inflammatory disease: the MONALISA study. (20716255)
2010
19
Treatment strategies for pelvic inflammatory disease. (19351231)
2009
20
Pelvic inflammatory disease. (19450319)
2008
21
Evidence for a role of Mycoplasma genitalium in pelvic inflammatory disease. (18192788)
2008
22
Pelvic inflammatory disease with Tc-99m ciprofloxacin imaging. (18840197)
2008
23
Intrauterine nitric oxide in pelvic inflammatory disease. (17681299)
2008
24
99mTc-HMPAO labelled leucocyte scintigraphy in the diagnosis of pelvic inflammatory disease. (16404232)
2006
25
Pelvic inflammatory disease in adolescents. (16044391)
2005
26
Significant reduction in inflammatory response in the macaque model of chlamydial pelvic inflammatory disease with azithromycin treatment. (15942902)
2005
27
SIR 2004 Film Panel Case: hepatic actinomycosis from pelvic inflammatory disease causing portal vein thrombosis. (15590787)
2004
28
Pelvic inflammatory disease. (12772359)
2003
29
Intrauterine devices and pelvic inflammatory disease. (12844450)
2003
30
Pelvic inflammatory disease. (15555180)
2003
31
Small bowel obstruction in an adolescent with pelvic inflammatory disease due to Chlamydia trachomatis. (12804934)
2003
32
Pelvic inflammatory disease. (12230761)
2002
33
Bacteriological cultures of removed intrauterine devices and pelvic inflammatory disease. (12057785)
2002
34
The rate of diagnosis and demography of pelvic inflammatory disease in general practice: England and Wales. (10454179)
1999
35
Peripheral blood T cell proliferative response to chlamydial organisms in gonococcal and non-gonococcal urethritis and presumed pelvic inflammatory disease. (10616357)
1999
36
Difficulties in treating adolescents with pelvic inflammatory disease with the revised treatment guidelines. (9895012)
1999
37
Pelvic inflammatory disease: the importance of aggressive treatment in adolescents. (9679392)
1998
38
Medically sound, cost-effective treatment for pelvic inflammatory disease and tuboovarian abscess. (9662312)
1998
39
How well is pelvic inflammatory disease managed in general practice? A postal questionnaire survey. (10195033)
1998
40
Pelvic inflammatory disease in adolescents. (11361905)
1998
41
Pelvic inflammatory disease. (9644446)
1998
42
Clinical aspects of pelvic inflammatory disease. (9433968)
1997
43
Do women with pelvic inflammatory disease receive adequate treatment? (9228598)
1997
44
Evidence of genetic susceptibility to Chlamydia trachomatis-induced pelvic inflammatory disease in the pig-tailed macaque. (9169759)
1997
45
Pelvic inflammatory disease: a contemporary approach. (8629562)
1996
46
Screening for chlamydia to prevent pelvic inflammatory disease. (8927092)
1996
47
Evidence against tailstrings increasing the rate of pelvic inflammatory disease among IUD users. (8631186)
1996
48
Immunopathogenesis of pelvic inflammatory disease and infertility -- what do we know and what shall we do? (12346974)
1996
49
Salpingitis and pelvic inflammatory disease. (3966303)
1985
50
Benign hepatic adenoma associated with oral contraceptive use mimicking pelvic inflammatory disease. A case report. (6327978)
1984

Genetic Variations for Pelvic Inflammatory Disease

Expression for genes affiliated with Pelvic Inflammatory Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pelvic Inflammatory Disease

Search GEO for disease gene expression data for Pelvic Inflammatory Disease.

Pathways for genes affiliated with Pelvic Inflammatory Disease

Sources:
54Reactome, 30KEGG
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Compounds for genes affiliated with Pelvic Inflammatory Disease

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB, 11DrugBank, 24HMDB, 2BitterDB
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Compounds related to Pelvic Inflammatory Disease according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.6HSPD1
2ninhydrin4510.6CTSA, CTSB
3bifidobacterium4510.5GUSB, HSPD1
4pam3csk46010.5TLR1, TLR4
5poly(i:c)6010.5TLR4, TLR1
6pam2csk46010.5TLR4, TLR1
7aspartate4510.5HSPD1, CST3, GUSB
8flagellin45 2911.5TLR1, HSPD1, TLR4
9actinidin4510.4CST3, CTSB
10resiquimod45 6011.4TLR4, TLR1
11leupeptin4510.4CTSB, CST3, PLAU
12dexamethasone45 50 29 1113.4TLR4, CYP11B1, CLEC3B
13doxycycline45 1111.3HSPD1, PLAU, LACTB
14guanidine hydrochloride4510.3HSPD1, CTSB, PLAU
15mannose 6-phosphate45 2411.3GUSB, CTSB, CTSA, PLAU
16Alpha-D-Mannose1110.3GUSB, CHI3L1, MAN1B1, LCN2
17vancomycin45 1111.3CST3, LACTB
18e 64d45 6011.3CTSB, CTSA
19kininogen4510.2CST3, PLAU, CLEC3B, CTSB
20gold4510.2CTSB, LCN2, HSPD1, CST3
21aprotinin45 1111.2CST3, CTSB, PLAU
22chloroquine45 2 50 29 1114.1TLR4, CTSB, PLAU
23glutamine4510.1CST3, HSPD1, CYP11B1, PLAU, CTSB
24fmlp4510.1CLEC3B, GUSB, TLR4, LCN2
25n acetylcysteine4510.1TLR4, PLAU, HSPD1, CST3
26latex4510.1TLR4, HSPD1, CST3
27cisplatin45 50 60 1113.1CST3, CTSB, PLAU, TLR4, HSPD1
28superoxide45 2411.0TLR4, GUSB, CST3, LCN2, HSPD1
29iron45 2411.0TLR4, HSPD1, LCN2, CST3, CTSB
30lactate4510.0TLR4, GUSB, CTSB, CST3, HSPD1, PLAU
31creatinine4510.0PLAU, GUSB, CTSB, HSPD1, CST3, LCN2
32fibrinogen459.9PLAU, CTSB, LCN2, TLR4, HSPD1, CST3
33doxorubicin45 50 1111.9GUSB, CTSB, HSPD1, PLAU
34polysaccharide459.9TLR4, LCN2, CLEC3B, PLAU, CST3, HSPD1
35alanine459.9TLR4, CYP11B1, CTSB, CST3, PLAU, HSPD1
36serine459.7LACTB, CTSB, TLR4
37cholesterol45 29 11 2412.7CST3, CTSB, TLR4, CYP11B1, HSPD1
38calcium45 50 11 2412.3CLEC3B, LCN2, HSPD1, CST3, CTSB, GUSB

GO Terms for genes affiliated with Pelvic Inflammatory Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Pelvic Inflammatory Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor complexGO:0466969.9TLR4, HSPD1
2mitochondrionGO:0057399.6CYP11B1, MFN2, CTSB, CTSA, HSPD1, LACTB
3extracellular spaceGO:0056159.3PLAU, CLEC3B, CHI3L1, CTSB, CST3, LCN2

Biological processes related to Pelvic Inflammatory Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1regulation of cytokine secretionGO:05070710.4TLR4, TLR1
2macrophage activationGO:04211610.3TLR4, TLR1
3positive regulation of tumor necrosis factor biosynthetic processGO:04253510.3TLR4, TLR1
4positive regulation of interferon-alpha productionGO:03272710.2TLR4, HSPD1
5MyD88-dependent toll-like receptor signaling pathwayGO:00275510.2TLR1, TLR4, HSPD1
6T-helper 1 type immune responseGO:04208810.1TLR4, TLR1
7immune responseGO:0069559.9CYP11B1, HLA-DQA1, TLR4, TLR1
8positive regulation of interleukin-10 productionGO:0327339.9TLR4, HSPD1

Molecular functions related to Pelvic Inflammatory Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide bindingGO:00153010.2TLR4, HSPD1

Products for genes affiliated with Pelvic Inflammatory Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pelvic Inflammatory Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet