PID
MCID: PLV003
MIFTS: 56

Pelvic Inflammatory Disease (PID) malady

Reproductive diseases category

Summaries for Pelvic Inflammatory Disease

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33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Pelvic inflammatory disease (pid) is an infection and inflammation of the uterus, ovaries, and other female reproductive organs. it causes scarring in these organs. this can lead to infertility, ectopic pregnancy, pelvic pain, abscesses, and other serious problems. pid is the most common preventable cause of infertility in the united states. gonorrhea and chlamydia, two sexually transmitted diseases, are the most common causes of pid. other bacteria can also cause it. you are at greater risk if you are sexually active and younger than 25 have more than one sex partner douche some women have no symptoms. others have pain in the lower abdomen, fever, smelly vaginal discharge, irregular bleeding, and pain during intercourse or urination. doctors diagnose pid with a physical exam, lab tests, and imaging tests. antibiotics can cure pid. early treatment is important. waiting too long increases the risk of infertility. nih: national institute of allergy and infectious diseases

MalaCards: Pelvic Inflammatory Disease, also known as inflammatory disease of female pelvic organs and/or tissues, is related to cervicitis and endometriosis. An important gene associated with Pelvic Inflammatory Disease is HSPD1 (heat shock 60kDa protein 1 (chaperonin)), and among its related pathways are MHC class II antigen presentation and Immune response Bacterial infections in normal airways. The compounds cycloheximide and ninhydrin have been mentioned in the context of this disorder. Affiliated tissues include ovary, uterus and testes, and related mouse phenotypes are hematopoietic system and renal/urinary system.

CDC:3 Basic Fact Sheet | Detailed Version

Wikipedia:63 Pelvic inflammatory disease (or disorder) (PID) is a term for inflammation of the uterus, fallopian... more...

Aliases & Classifications for Pelvic Inflammatory Disease

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt, 25ICD10
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Related Diseases for Pelvic Inflammatory Disease

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Pelvic Inflammatory Disease:



Diseases related to pelvic inflammatory disease

Clinical Features for Pelvic Inflammatory Disease

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Drugs & Therapeutics for Pelvic Inflammatory Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Pelvic Inflammatory Disease

Search NIH Clinical Center for Pelvic Inflammatory Disease

Search CenterWatch for Pelvic Inflammatory Disease

Genetic Tests for Pelvic Inflammatory Disease

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Anatomical Context for Pelvic Inflammatory Disease

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32MalaCards
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MalaCards organs/tissues related to Pelvic Inflammatory Disease:

32
Ovary, Uterus, Testes, Skin, Breast, Monocytes, T cells, Colon

Animal Models for Pelvic Inflammatory Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pelvic Inflammatory Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.3CTSA, TLR4, LCN2, GUSB, HLA-DQA1, CYP11B1
2MP:00053679.2TLR4, CTSA, CTSB, GUSB, CYP11B1, LCN2
3MP:00053879.0PLAU, LCN2, TLR4, TLR1, CTSA, CTSB

Publications for Pelvic Inflammatory Disease

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50PubMed
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Articles related to Pelvic Inflammatory Disease:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
Does bacterial vaginosis cause pelvic inflammatory disease? (23324974)
2013
2
Markedly elevated soluble E-cadherin in plasma of patient with pelvic inflammatory disease. (23122825)
2013
3
The role of the serum inflammatory markers for predicting the tubo-ovarian abscess in acute pelvic inflammatory disease: a single-center 5-year experience. (23104053)
2013
4
Risk of pelvic inflammatory disease following Chlamydia trachomatis infection: analysis of prospective studies with a multistate model. (23813703)
2013
5
Acute pelvic inflammatory disease, active component, U.S. Armed Forces, 2002-2011. (22876801)
2012
6
Small bowel obstruction secondary to pelvic inflammatory disease. (21679543)
2011
7
Pelvic inflammatory disease and ovarian cancer. (22123593)
2011
8
Adolescent and parental utilities for the health states associated with pelvic inflammatory disease. (22001169)
2011
9
Elevated plasma osteopontin level is associated with pelvic inflammatory disease. (20713973)
2010
10
Markedly elevated plasma myeloperoxidase protein in patients with pelvic inflammatory disease who have A allele myeloperoxidase gene polymorphism. (19147137)
2010
11
Chlamydia screening and pelvic inflammatory disease: Insights from exploratory time-series analyses. (20494242)
2010
12
Pelvic inflammatory disease and tubo-ovarian abscess. (18954759)
2008
13
Endometriosis and its coexistence with irritable bowel syndrome and pelvic inflammatory disease: findings from a national case-control study--Part 2. (18715239)
2008
14
An audit on the management of pelvic inflammatory disease in the West Midlands, UK. (17945054)
2007
15
A serological study of the role of Mycoplasma genitalium in pelvic inflammatory disease and ectopic pregnancy. (17475688)
2007
16
Computed tomographic features of appendiceal serositis in pelvic inflammatory disease: comparison with pathological findings. (17259841)
2007
17
Managing pelvic inflammatory disease. (18705484)
2007
18
Pelvic inflammatory disease. (16973083)
2006
19
Hospitalizations for pelvic inflammatory disease and tuboovarian abscess. (16507932)
2006
20
Reiter's syndrome and pelvic inflammatory disease in a couple. (16836507)
2006
21
Pelvic inflammatory disease in adolescents. (16932044)
2006
22
Prediction of pelvic inflammatory disease among young, single, sexually active women. (16505735)
2006
23
Predictors of chronic pelvic pain in an urban population of women with symptoms and signs of pelvic inflammatory disease. (15849530)
2005
24
Pelvic inflammatory disease in adolescents: high incidence and recurrence rates in an urban teen clinic. (15603980)
2004
25
Intrauterine contraceptive devices and risk of pelvic inflammatory disease: standard of care in high STI prevalence settings. (15242222)
2004
26
A refined estimate of the lifetime cost of pelvic inflammatory disease. (15107638)
2004
27
Pelvic inflammatory disease and sepsis. (12597041)
2003
28
Pelvic inflammatory disease: how should it be managed? (12821828)
2003
29
Randomized field trial of vaginal douching, pelvic inflammatory disease and pregnancy. (12859036)
2003
30
Lower quality of life among women with chronic pelvic pain after pelvic inflammatory disease. (14672466)
2003
31
Ciprofloxacin-tinidazole combination, fluconazole- azithromicin-secnidazole-kit and doxycycline- metronidazole combination therapy in syndromic management of pelvic inflammatory disease: a prospective randomized controlled trial. (14701947)
2003
32
The extended Chlamydia trachomatis diagnosis in patients with pelvic inflammatory disease--a better approach for the diagnosis of upper genital tract infections. (15285188)
2003
33
Observer agreement with laparoscopic diagnosis of pelvic inflammatory disease using photographs. (12738143)
2003
34
Efficacy and safety of azithromycin as monotherapy or combined with metronidazole compared with two standard multidrug regimens for the treatment of acute pelvic inflammatory disease. (12635534)
2003
35
An audit of outpatient management of pelvic inflammatory disease. (12194744)
2002
36
An update on pelvic inflammatory disease. (11872852)
2002
37
Transvaginal power Doppler findings in laparoscopically proven acute pelvic inflammatory disease. (11309174)
2001
38
Clinical predictors of endometritis in women with symptoms and signs of pelvic inflammatory disease. (11303192)
2001
39
Antibody response to the chlamydial heat-shock protein 60 in an experimental model of chronic pelvic inflammatory disease in monkeys (Macaca nemestrina). (10438366)
1999
40
Evaluation of ofloxacin in the treatment of laparoscopically documented acute pelvic inflammatory disease (salpingitis). (10371472)
1999
41
High prevalence of cervical intra-epithelial neoplasia in women treated for pelvic inflammatory disease. (9846714)
1998
42
Pelvic inflammatory disease in Rhode Island: epidemiology, diagnosis and therapy. (9350116)
1997
43
Recurrent chlamydial infections increase the risks of hospitalization for ectopic pregnancy and pelvic inflammatory disease. (9024098)
1997
44
Pelvic inflammatory disease in HIV-positive women. (9142056)
1997
45
Ascites--an unusual association with pelvic inflammatory disease. (9429721)
1997
46
Pelvic inflammatory disease. Correlation of severity with CA-125 levels. (8725760)
1996
47
Recognition of tubo-ovarian abscess in adolescents with pelvic inflammatory disease. (8803731)
1996
48
Pelvic inflammatory disease in intrauterine device users. (9678122)
1996
49
Serum tetranectin in patients with acute pelvic inflammatory disease (PID). Correlation to clinical and laboratory findings. (7534970)
1995
50
Gonorrhea, genital chlamydial infection, and nonspecific urethritis in male partners of women hospitalized and treated for acute pelvic inflammatory disease. (8511708)
1993

Genetic Variations for Pelvic Inflammatory Disease

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Expression for genes affiliated with Pelvic Inflammatory Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pelvic Inflammatory Disease

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Pathways for genes affiliated with Pelvic Inflammatory Disease

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53Reactome, 29KEGG
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Compounds for genes affiliated with Pelvic Inflammatory Disease

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 2BitterDB
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Compounds related to Pelvic Inflammatory Disease according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.6HSPD1
2ninhydrin4410.6CTSB, CTSA
3bifidobacterium4410.5GUSB, HSPD1
4pam2csk45910.5TLR4, TLR1
5pam3csk45910.5TLR4, TLR1
6poly(i:c)5910.5TLR4, TLR1
7aspartate4410.5GUSB, CST3, HSPD1
8flagellin44 2811.5HSPD1, TLR4, TLR1
9actinidin4410.4CST3, CTSB
10resiquimod44 5911.4TLR1, TLR4
11leupeptin4410.4PLAU, CTSB, CST3
12dexamethasone44 49 28 1113.4TLR4, CYP11B1, CLEC3B
13doxycycline44 1111.3LACTB, PLAU, HSPD1
14guanidine hydrochloride4410.3PLAU, CTSB, HSPD1
15mannose 6-phosphate44 2411.3CTSA, CTSB, GUSB, PLAU
16Alpha-D-Mannose1110.3LCN2, GUSB, CHI3L1, MAN1B1
17vancomycin44 1111.3CST3, LACTB
18e 64d44 5911.3CTSB, CTSA
19kininogen4410.2PLAU, CLEC3B, CTSB, CST3
20gold4410.2HSPD1, LCN2, CST3, CTSB
21aprotinin44 1111.2PLAU, CTSB, CST3
22chloroquine44 2 49 28 1114.1PLAU, CTSB, TLR4
23glutamine4410.1HSPD1, CST3, CTSB, CYP11B1, PLAU
24fmlp4410.1CLEC3B, GUSB, TLR4, LCN2
25n acetylcysteine4410.1HSPD1, TLR4, CST3, PLAU
26latex4410.1CST3, TLR4, HSPD1
27cisplatin44 49 59 1113.1HSPD1, TLR4, CST3, CTSB, PLAU
28superoxide44 2411.0HSPD1, LCN2, TLR4, CST3, GUSB
29iron44 2411.0HSPD1, LCN2, TLR4, CST3, CTSB
30lactate4410.0HSPD1, TLR4, CST3, CTSB, GUSB, PLAU
31creatinine4410.0HSPD1, LCN2, CST3, CTSB, GUSB, PLAU
32fibrinogen449.9HSPD1, LCN2, TLR4, CST3, CTSB, PLAU
33doxorubicin44 49 1111.9PLAU, GUSB, CTSB, HSPD1
34polysaccharide449.9HSPD1, LCN2, TLR4, CST3, CLEC3B, PLAU
35alanine449.9HSPD1, TLR4, CST3, CTSB, CYP11B1, PLAU
36serine449.7LACTB, CTSB, TLR4
37cholesterol44 28 11 2412.7HSPD1, TLR4, CST3, CTSB, CYP11B1
38calcium44 49 11 2412.3HSPD1, LCN2, TLR4, CST3, CTSB, GUSB

GO Terms for genes affiliated with Pelvic Inflammatory Disease

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16Gene Ontology
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Cellular components related to Pelvic Inflammatory Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor complexGO:0466969.9HSPD1, TLR4
2mitochondrionGO:0057399.6LACTB, CYP11B1, MFN2, CTSB, CTSA, HSPD1
3extracellular spaceGO:0056159.3PLAU, CLEC3B, CHI3L1, CTSB, CST3, LCN2

Biological processes related to Pelvic Inflammatory Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1regulation of cytokine secretionGO:05070710.4TLR1, TLR4
2macrophage activationGO:04211610.3TLR1, TLR4
3positive regulation of tumor necrosis factor biosynthetic processGO:04253510.3TLR1, TLR4
4positive regulation of interferon-alpha productionGO:03272710.2HSPD1, TLR4
5MyD88-dependent toll-like receptor signaling pathwayGO:00275510.2HSPD1, TLR4, TLR1
6T-helper 1 type immune responseGO:04208810.1TLR1, TLR4
7immune responseGO:0069559.9CYP11B1, HLA-DQA1, TLR1, TLR4
8positive regulation of interleukin-10 productionGO:0327339.9TLR4, HSPD1

Molecular functions related to Pelvic Inflammatory Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide bindingGO:00153010.2TLR4, HSPD1

Products for genes affiliated with Pelvic Inflammatory Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pelvic Inflammatory Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet