MCID: PMP002
MIFTS: 35

Pemphigoid Gestationis malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Pemphigoid Gestationis

About this section
Sources:
46NIH Rare Diseases, 52Orphanet, 66UMLS, 29ICD10 via Orphanet, 38MESH via Orphanet, 67UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Pemphigoid Gestationis:

Name: Pemphigoid Gestationis 46 52 66
Gestational Pemphigoid 46 52
 
Herpes Gestationis 46

Classifications:

Orphanet: 52 
Rare skin diseases


External Ids:

Orphanet52 ORPHA63275
ICD10 via Orphanet29 L12.8
MESH via Orphanet38 D006559
UMLS via Orphanet67 C0019343

Summaries for Pemphigoid Gestationis

About this section
NIH Rare Diseases:46 Pemphigoid gestationis (pg) is a pregnancy-associated autoimmune skin disorder. it usually begins abruptly during the 2nd or 3rd trimester of pregnancy, but can occur any time during pregnancy. signs and symptoms often include the formation of very itchy, red bumps and/or blisters on the abdomen and trunk, but other parts of the body can be affected. unrelenting itchiness (pruritus) often interferes with daily activities. symptoms may improve at the end of pregnancy, but flares may occur during, or right after, delivery. while it usually goes away on its own within weeks to months after delivery, it may recur during menses; with use of oral contraceptives; and/or with subsequent pregnancies. pg is caused by a woman's immune system mistakenly attacking her own skin, but the exact reasons why this occurs is poorly understood. treatment depends on severity and may include topical corticosteroids; oral corticosteroids, and/or oral antihistamines to relieve itching. last updated: 5/3/2016

MalaCards based summary: Pemphigoid Gestationis, also known as gestational pemphigoid, is related to herpes gestationis and bullous pemphigoid, and has symptoms including premature birth, urticaria and hyperemesis gravidarum. An important gene associated with Pemphigoid Gestationis is COL17A1 (Collagen Type XVII Alpha 1 Chain), and among its related pathways are Th2 Differentiation Pathway and IL4-mediated signaling events. Affiliated tissues include skin, placenta and t cells.

Wikipedia:69 Gestational pemphigoid or pemphigoid gestationis (PG) is a dermatosis of pregnancy, being an autoimmune... more...

Related Diseases for Pemphigoid Gestationis

About this section

Diseases related to Pemphigoid Gestationis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1herpes gestationis11.9
2bullous pemphigoid10.3
3solitary cyst of breast10.3CCL11, IL5
4cholesteatoma of middle ear10.3CCL11, IL5
5fungal gastritis10.3CCL11, IL5
6vibrio vulnificus infection10.3CCL11, IL5
7antley-bixler syndrome with genital anomalies and disordered steroidogenesis10.3CCL11, IL5
8benign mammary dysplasia10.3CCL11, IL5
9dioctophymiasis10.3CCL11, IL5
10epididymis adenocarcinoma10.3CCL11, IL5
11bacterial gastritis10.2CCL11, IL5
12apple allergy10.2CCL11, IL5
13cervix melanoma10.2CCL11, IL5
14lichen sclerosus10.2COL17A1, DST
15central nervous system origin vertigo10.2CCL11, IL5
16submandibular gland cancer10.2COL17A1, DST
17pituitary hypoplasia10.2CCL11, IL5
18microcephaly, holoprosencephaly, and intrauterine growth retardation10.2COL17A1, DST
19retroperitoneal cancer10.2CCL11, IL5
20dacryoadenitis10.2CCL11, IL5
21gait apraxia10.2CCL11, IL5
22buphthalmos10.2CCL11, IL5
23gilbert syndrome10.2COL17A1, DST
24melanoacanthoma10.2CCL11, IL5
25blue color blindness10.2COL17A1, DST
26vaginitis10.2CCL11, IL5
27impetigo10.2COL17A1, DST
28geotrichosis10.2CCL11, IL5
29malignant histiocytosis10.2COL17A1, DST
30dentin caries10.2CCL11, IL5
31puerperal pulmonary embolism10.2COL17A1, DST
32tinea cruris10.2COL17A1, DST
33demyelinating disease10.2COL17A1, DST
34sarcoid meningitis10.2CCL11, IL5
35biliary tract disease10.2CCL11, IL5
36loeffler syndrome10.2CCL11, IL5
37synostosis10.1CCL11, IL5
38sporotrichosis10.1COL17A1, DST
39exophthalmos10.1CCL11, IL5
40conventional malignant hemangiopericytoma10.1CCL11, IL5
41blind hypotensive eye10.1CCL11, IL5
42mandibular cancer10.1CCL11, IL5
43motion sickness10.1CCL11, IL5
44familial retinoblastoma10.1COL17A1, DST
45pruritic urticarial papules and plaques of pregnancy10.1
46pemphigus vulgaris10.1
47pemphigus10.1
48geniculate herpes zoster10.1COL17A1, DST
49hypertensive encephalopathy10.1CCL11, IL5
50blood group incompatibility10.1COL17A1, DST

Graphical network of the top 20 diseases related to Pemphigoid Gestationis:



Diseases related to pemphigoid gestationis

Symptoms for Pemphigoid Gestationis

About this section

Symptoms:

 52
  • pruritus
  • failure to thrive
  • intrauterine growth retardation
  • premature birth
  • abnormal blistering of the skin
  • skin vesicle

HPO human phenotypes related to Pemphigoid Gestationis:

id Description Frequency HPO Source Accession
1 premature birth hallmark (90%) HP:0001622
2 urticaria occasional (7.5%) HP:0001025

UMLS symptoms related to Pemphigoid Gestationis:


hyperemesis gravidarum, morning sickness, coma blister

Drugs & Therapeutics for Pemphigoid Gestationis

About this section

Interventional clinical trials:

idNameStatusNCT IDPhase
1Genetic Susceptibility and Influence of the Microbiomae in Bullous PemphigoidRecruitingNCT02874079

Search NIH Clinical Center for Pemphigoid Gestationis

Genetic Tests for Pemphigoid Gestationis

About this section

Anatomical Context for Pemphigoid Gestationis

About this section

MalaCards organs/tissues related to Pemphigoid Gestationis:

34
Skin, Placenta, T cells, Testes

Animal Models for Pemphigoid Gestationis or affiliated genes

About this section

Publications for Pemphigoid Gestationis

About this section

Articles related to Pemphigoid Gestationis:

(show top 50)    (show all 116)
idTitleAuthorsYear
1
Pemphigoid gestationis: a successful preventive treatment by rituximab. (27606493)
2016
2
Concomitant pemphigus vulgaris and pemphigoid gestationis: a case report and review of the literature. (26990471)
2016
3
Lichen planus pemphigoides associated with pregnancy mimicking pemphigoid gestationis. (27416093)
2016
4
Pemphigoid gestationis revealing a denial of pregnancy. (26299950)
2015
5
Pemphigoid gestationis. (25581583)
2015
6
Pemphigoid gestationis with prepartum flare. (25039537)
2014
7
Pemphigoid gestationis (herpes gestationis). (25404804)
2014
8
Successfully treated case of pemphigoid gestationis with post-partum intravenous and oral steroids. (25404796)
2014
9
Clinical and immunological profiles of 25 patients with pemphigoid gestationis. (25154546)
2014
10
Pemphigoid gestationis in a third trimester pregnancy. (25431712)
2014
11
Case for diagnosis. Pemphigoid gestationis. (24626668)
2014
12
The utility of C4d immunohistochemistry on formalin-fixed paraffin-embedded tissue in the distinction of polymorphic eruption of pregnancy from pemphigoid gestationis. (24061402)
2013
13
Pemphigoid gestationis. (24365006)
2013
14
Pemphigoid gestationis in a female with progressive facial hemiatrophy: microchimerism as a speculative shared background is disputable. (22535610)
2012
15
Glucocorticosteroid-resistant pemphigoid gestationis: successful treatment with adjuvant immunoadsorption. (22379622)
2012
16
Pemphigoid gestationis. (22715180)
2011
17
Pemphigoid gestationis: current management. (21925007)
2011
18
No evidence for fetal microchimerism in the skin of patients with pemphigoid gestationis. (19840915)
2010
19
Pemphigoid gestationis: current insights into pathogenesis and treatment. (19520487)
2009
20
Measurement of pruritus in a Chinese woman with pemphigoid gestationis using a wrist movement detector. (18173607)
2008
21
Pemphigoid gestationis autoantigen, transmembrane collagen XVII, promotes the migration of cytotrophoblastic cells of placenta and is a structural component of fetal membranes. (18055190)
2008
22
Normal neonatal outcome in a Chinese woman with pemphigoid gestationis, Graves' disease, and history of placental chorioangioma. (17822510)
2007
23
The intracellular and extracellular domains of BP180 antigen comprise novel epitopes targeted by pemphigoid gestationis autoantibodies. (17068480)
2007
24
Pemphigoid gestationis: report of a case with umbilical artery Doppler assessment. (16913554)
2006
25
Remarkable follow-up experiences of a severe persistent case of pemphigoid gestationis. (16045710)
2005
26
A case of gestational diabetes arising following treatment with glucocorticosteroids for pemphigoid gestationis. (16390798)
2005
27
Intravenous immune globulin in the treatment of persistent pemphigoid gestationis. (15583609)
2004
28
Tissue eosinophilia in pemphigoid gestationis: association with eotaxin and upregulated activation markers on transmigrated eosinophils. (14725564)
2004
29
The role of T lymphocytes and cytokines in the pathogenesis of pemphigoid gestationis. (12828741)
2003
30
Pemphigoid gestationis: maternal sera recognize epitopes restricted to the N-terminal portion of the extracellular domain of BP180 not present on its shed ectodomain. (12932258)
2003
31
Pemphigoid gestationis: new insights into the pathogenesis lead to novel diagnostic tools. (12269691)
2002
32
Pemphigoid gestationis: a review. (10942491)
2000
33
Pemphigoid gestationis without blisters]. (10663036)
2000
34
Clinical features and management of 87 patients with pemphigoid gestationis. (10457123)
1999
35
IgG1 and IgG3 are the major immunoglobulin subclasses targeting epitopes within the NC16A domain of BP180 in pemphigoid gestationis. (10417635)
1999
36
A severe persistent case of pemphigoid gestationis treated with intravenous immunoglobulins and cyclosporin. (9894365)
1998
37
Pemphigoid gestationis with autoantibodies exclusively directed to the 230-kDa bullous pemphigoid antigen (BP230Ag) (8731696)
1996
38
Conversion of pemphigoid gestationis to bullous pemphigoid--two refractory cases highlighting this association. (8915153)
1996
39
Class II MHC typing in pemphigoid gestationis. (8565245)
1995
40
Anti-HLA antibodies in pemphigoid gestationis (herpes gestationis). (8286221)
1993
41
Isolated basal keratinocytes express pemphigoid gestationis antigen. (1536760)
1992
42
Pemphigoid gestationis--response to chemical oophorectomy with goserelin. (1486714)
1992
43
Pemphigoid gestationis and neonatal alloimmune thrombocytopenia. (2189606)
1990
44
Antigen-presenting cells in the skin and placenta in pemphigoid gestationis. (2191709)
1990
45
Pemphigoid gestationis: placental interactions. (2701703)
1989
46
Immunopathology of the placenta in pemphigoid gestationis and linear IgA disease. (2667614)
1989
47
The distribution of IgG subclasses in pemphigoid gestationis: PG factor is an IgG1 autoantibody. (2654296)
1989
48
Pemphigoid gestationis: a unique mechanism of initiation of an autoimmune response by MHC class II molecules? (2666624)
1989
49
Expression of a pemphigoid gestationis-related antigen by human placenta. (3293646)
1988
50
Abnormal expression of HLA-DR antigen in the placenta of a patient with pemphigoid gestationis. (6394752)
1984

Variations for Pemphigoid Gestationis

About this section

Expression for genes affiliated with Pemphigoid Gestationis

About this section
Search GEO for disease gene expression data for Pemphigoid Gestationis.

Pathways for genes affiliated with Pemphigoid Gestationis

About this section

GO Terms for genes affiliated with Pemphigoid Gestationis

About this section

Cellular components related to Pemphigoid Gestationis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hemidesmosomeGO:00300569.7COL17A1, DST
2basement membraneGO:00056049.4COL17A1, DST

Sources for Pemphigoid Gestationis

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet