MCID: PMP002
MIFTS: 35

Pemphigoid Gestationis malady

Skin category

Summaries for Pemphigoid Gestationis

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Pemphigoid gestationis (pg), also known as gestational pemphigoid or herpes gestationis, is an autoimmune skin disorder associated with pregnancy. signs and symptoms of the disorder typically present during the second or third trimester of pregnancy, but it may occur at any time during pregnancy or anywhere up to six weeks after giving birth. although the signs and symptoms are variable, a red, itchy rash with blisters is common. the rash may occur in different parts of the body, but usually develops near the belly button and/or the arms and legs. the condition is caused by the production of antibodies that attack the person's body, leading to damage and consequently blister formation. treatment generally involves systemic corticosteroids.  last updated: 8/11/2010

MalaCards: Pemphigoid Gestationis, also known as gestational pemphigoid, is related to herpes gestationis and bullous pemphigoid, and has symptoms including erythema/erythematous lesions/erythroderma/polymorphous erythema, prematurity and failure to thrive/difficulties for feeding in infancy/growth delay. An important gene associated with Pemphigoid Gestationis is COL17A1 (collagen, type XVII, alpha 1), and among its related pathways are Allograft rejection and Cell-cell junction organization. The compounds gold and allergens have been mentioned in the context of this disorder. Affiliated tissues include skin, placenta and t cells.

Wikipedia:64 Gestational pemphigoid or pemphigoid gestationis (PG) is a dermatosis of pregnancy, being an autoimmune... more...

Aliases & Classifications for Pemphigoid Gestationis

Sources:
43NIH Rare Diseases, 49Orphanet, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

pemphigoid gestationis 43 49 61
gestational pemphigoid 43
herpes gestationis 43


External Ids:

MESH via Orphanet36 D006559
ICD10 via Orphanet26 L12.8
SNOMED-CT via Orphanet58 86081009
UMLS via Orphanet62 C0019343

Related Diseases for Pemphigoid Gestationis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pemphigoid Gestationis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 43)
idRelated DiseaseScoreTop Affiliating Genes
1herpes gestationis30.8DST, COL17A1
2bullous pemphigoid30.8COL17A1, CCL11, DST
3pemphigus30.3DST
4cicatricial pemphigoid30.2COL17A1, DST
5pemphigus vulgaris30.2DST, CCL11, HLA-DRB1
6neonatal herpes10.4
7urticaria10.3
8hellp syndrome10.2
9facial hemiatrophy10.2
10chorioangioma10.2
11gestational diabetes10.2
12graves' disease10.2
13thrombocytopenia10.2
14thrombocytopenia, neonatal alloimmune10.2
15mucous membrane pemphigoid10.2
16antiphospholipid syndrome10.2
17systemic lupus erythematosus10.2
18thyrotoxicosis10.2
19ectopic pregnancy10.2
20bullous systemic lupus erythematosus10.2
21junctional epidermolysis bullosa10.0COL17A1
22nephrotic syndrome10.0CCL11
23eosinophilic esophagitis10.0CCL11
24dermatitis herpetiformis10.0CCL11
25dermatitis10.0CCL11
26uveitis10.0CCL11
27leprosy10.0HLA-DRB1
28atopy10.0CCL11
29epidermolysis bullosa acquisita10.0DST, COL17A1
30junctional epidermolysis bullosa, non-herlitz type10.0COL17A1, DST
31epidermolysis bullosa10.0DST, COL17A1
32bullous skin disease10.0DST, COL17A1
33lichen planus10.0COL17A1, DST
34type 1 diabetes10.0HLA-DRB1, CCL11
35epidermolysis bullosa simplex10.0DST, COL17A1
36multiple sclerosis10.0HLA-DRB1, CCL11
37pemphigus foliaceus10.0DST, HLA-DRB1
38ulcerative colitis10.0HLA-DRB1, CCL11
39basal cell carcinoma10.0DST, COL17A1
40skin disease10.0CCL11, COL17A1, DST
41melanoma10.0CCL11, HLA-DRB1, DST
42psoriasis10.0CCL11, HLA-DRB1, DST
43hypersensitivity reaction type ii disease10.0CCL11, HLA-DRB1, DST, COL17A1

Graphical network of the top 20 diseases related to Pemphigoid Gestationis:



Diseases related to pemphigoid gestationis

Clinical Features for Pemphigoid Gestationis

Sources:
49Orphanet
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Symptoms:

49 (see all 4)
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • prematurity
  • failure to thrive/difficulties for feeding in infancy/growth delay
  • urticaria

Drugs & Therapeutics for Pemphigoid Gestationis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Pemphigoid Gestationis

Drug clinical trials:

Search ClinicalTrials for Pemphigoid Gestationis

Search NIH Clinical Center for Pemphigoid Gestationis

Search CenterWatch for Pemphigoid Gestationis

Genetic Tests for Pemphigoid Gestationis

Anatomical Context for Pemphigoid Gestationis

Sources:
33MalaCards
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MalaCards organs/tissues related to Pemphigoid Gestationis:

33
Skin, Placenta, T cells

Animal Models for Pemphigoid Gestationis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Pemphigoid Gestationis

Sources:
51PubMed
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Articles related to Pemphigoid Gestationis:

(show top 50)    (show all 109)
idTitleAuthorsYear
1
Pemphigoid gestationis after spontaneous expulsion of a massive complete hydatidiform mole. (24083041)
2013
2
Dyshidrosiform presentation (pompholyx-like) of pemphigoid gestationis with intrauterine fetal death. (23432199)
2013
3
The utility of C4d immunohistochemistry on formalin-fixed paraffin-embedded tissue in the distinction of polymorphic eruption of pregnancy from pemphigoid gestationis. (24061402)
2013
4
Pemphigoid gestationis: a retrospective study in southwest Iran. (23852847)
2013
5
Refractory pemphigoid gestationis postpartum. (22360419)
2012
6
Pemphigoid gestationis: pathogenesis and clinical features. (21605810)
2011
7
Pemphigoid gestationis. (22715180)
2011
8
Pemphigoid gestationis. (21163161)
2010
9
No evidence for fetal microchimerism in the skin of patients with pemphigoid gestationis. (19840915)
2010
10
Pemphigoid gestationis: early onset and blister formation are associated with adverse pregnancy outcomes. (19298272)
2009
11
Pemphigoid gestationis: current insights into pathogenesis and treatment. (19520487)
2009
12
Severe persistent pemphigoid gestationis: long-term remission with rituximab. (17553047)
2007
13
Normal neonatal outcome in a Chinese woman with pemphigoid gestationis, Graves' disease, and history of placental chorioangioma. (17822510)
2007
14
IgG4 as the predominant IgG subclass in pemphigoides gestationis. (16630180)
2006
15
Pemphigoid gestationis: report of a case with umbilical artery Doppler assessment. (16913554)
2006
16
Pemphigoid gestationis. (17071442)
2006
17
Pemphigoid gestationis complicating a pregnancy following in vitro fertilization and intracytoplasmic sperm injection. (16961534)
2006
18
Usefulness of BP180 NC16a enzyme-linked immunosorbent assay in the serodiagnosis of pemphigoid gestationis and in differentiating between pemphigoid gestationis and pruritic urticarial papules and plaques of pregnancy. (15967916)
2005
19
Remarkable follow-up experiences of a severe persistent case of pemphigoid gestationis. (16045710)
2005
20
A case of gestational diabetes arising following treatment with glucocorticosteroids for pemphigoid gestationis. (16390798)
2005
21
Tissue eosinophilia in pemphigoid gestationis: association with eotaxin and upregulated activation markers on transmigrated eosinophils. (14725564)
2004
22
Maternal and neonatal pemphigoid gestationis. (14987286)
2004
23
Immunoblotting and enzyme-linked immunosorbent assay for the diagnosis of pemphigoid gestationis. (15051570)
2004
24
The role of T lymphocytes and cytokines in the pathogenesis of pemphigoid gestationis. (12828741)
2003
25
A case of chronic herpes gestationis: persistent disease or conversion to bullous pemphigoid? (12894083)
2003
26
Chronic pemphigoid gestationis: comparative clinical and immunopathological study of 10 patients. (12592077)
2003
27
Pemphigoid gestationis: maternal sera recognize epitopes restricted to the N-terminal portion of the extracellular domain of BP180 not present on its shed ectodomain. (12932258)
2003
28
Clinicopathological features and HLA tissue typing in pemphigoid gestationis patients in Kuwait. (12780719)
2003
29
Pemphigoid gestationis: new insights into the pathogenesis lead to novel diagnostic tools. (12269691)
2002
30
Pemphigoid gestationis with predominant involvement of oral mucous membranes and IgA autoantibodies targeting the C-terminus of BP180. (12399776)
2002
31
A severe persistent case of recurrent pemphigoid gestationis successfully treated with minocycline and nicotinamide. (11722465)
2001
32
Pemphigoid gestationis without blisters]. (10663036)
2000
33
Titration of herpes gestationis factor fixing to C3 in pemphigoid herpes gestationis associated with choriocarcinoma. (10632227)
2000
34
IgG1 and IgG3 are the major immunoglobulin subclasses targeting epitopes within the NC16A domain of BP180 in pemphigoid gestationis. (10417635)
1999
35
A severe persistent case of pemphigoid gestationis treated with intravenous immunoglobulins and cyclosporin. (9894365)
1998
36
A typical case of pemphigoid gestationis with a unique pattern of intercellular immunofluorescence. (9068742)
1997
37
Analysis of antigens recognized by autoantibodies in herpes gestationis. Usefulness of immunoblotting using a fusion protein representing an extracellular domain of the 180 kD bullous pemphigoid antigen. (8953410)
1996
38
Pemphigoid gestationis occurring in a patient with HELLP syndrome. (8687334)
1996
39
Severe case of pemphigoid gestationis with unusual target antigen. (8043401)
1994
40
Anti-HLA antibodies in pemphigoid gestationis (herpes gestationis). (8286221)
1993
41
Antigen-presenting cells in the skin and placenta in pemphigoid gestationis. (2191709)
1990
42
Immunopathology of the placenta in pemphigoid gestationis and linear IgA disease. (2667614)
1989
43
The complement fixing ability of anti-basement membrane zone IgG subclass of herpes gestationis and bullous pemphigoid. (2563610)
1989
44
Palmo-plantar involvement in auto-immune blistering disorders--pemphigoid, linear IgA disease and herpes gestationis. (2975200)
1988
45
Abnormal expression of HLA-DR antigen in the placenta of a patient with pemphigoid gestationis. (6394752)
1984
46
Ritodrine therapy associated with remission of pemphigoid gestationis. (6388622)
1984
47
Bullous pemphigoid, herpes gestationis and linear dermatitis herpetiformis: circulating anti-basement membrane zone antibodies; in vitro studies. (6985947)
1980
48
Herpes gestationis and bullous pemphigoid: a disease spectrum. (7002198)
1980
49
Indirect complement immunofluorescence in the immunopathological assessment of bullous pemphigoid, cicatricial pemphigoid, and herpes gestationis. (348362)
1978
50
Herpes gestationis. A high titre of anti-HLA-B8 antibody in the mother and pemphigoid-like immunohistological findings in the mother and the child. (326292)
1977

Genetic Variations for Pemphigoid Gestationis

Expression for genes affiliated with Pemphigoid Gestationis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pemphigoid Gestationis

Search GEO for disease gene expression data for Pemphigoid Gestationis.

Pathways for genes affiliated with Pemphigoid Gestationis

Sources:
30KEGG, 52QIAGEN, 54Reactome, 38NCBI BioSystems Database
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Compounds for genes affiliated with Pemphigoid Gestationis

Sources:
45Novoseek
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Compounds related to Pemphigoid Gestationis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1gold459.1DST, COL17A1
2allergens459.0HLA-DRB1, CCL11
3nacl458.4DST, CCL11, COL17A1

GO Terms for genes affiliated with Pemphigoid Gestationis

Sources:
16Gene Ontology
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Cellular components related to Pemphigoid Gestationis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basement membraneGO:0056049.1DST, COL17A1
2hemidesmosomeGO:0300568.8DST, COL17A1

Biological processes related to Pemphigoid Gestationis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoskeleton organizationGO:0070109.0DST, CCL11
2hemidesmosome assemblyGO:0315818.8DST, COL17A1

Products for genes affiliated with Pemphigoid Gestationis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pemphigoid Gestationis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet