MCID: PMP002
MIFTS: 41

Pemphigoid Gestationis malady

Rare diseases, Skin diseases categories
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Summaries for Pemphigoid Gestationis

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43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Pemphigoid gestationis (pg), also known as gestational pemphigoid or herpes gestationis, is an autoimmune skin disorder associated with pregnancy. signs and symptoms of the disorder typically present during the second or third trimester of pregnancy, but it may occur at any time during pregnancy or anywhere up to six weeks after giving birth. although the signs and symptoms are variable, a red, itchy rash with blisters is common. the rash may occur in different parts of the body, but usually develops near the belly button and/or the arms and legs. the condition is caused by the production of antibodies that attack the person's body, leading to damage and consequently blister formation. treatment generally involves systemic corticosteroids.  last updated: 8/11/2010

MalaCards: Pemphigoid Gestationis, also known as gestational pemphigoid, is related to herpes gestationis and bullous pemphigoid, and has symptoms including erythema/erythematous lesions/erythroderma/polymorphous erythema, prematurity and failure to thrive/difficulties for feeding in infancy/growth delay. An important gene associated with Pemphigoid Gestationis is COL17A1 (collagen, type XVII, alpha 1), and among its related pathways are Allograft rejection and Degradation of the extracellular matrix. The compounds allergens and gold have been mentioned in the context of this disorder. Affiliated tissues include skin, placenta and testes.

Wikipedia:65 Gestational pemphigoid or pemphigoid gestationis (PG) is a dermatosis of pregnancy, being an autoimmune... more...

Aliases & Classifications for Pemphigoid Gestationis

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43NIH Rare Diseases, 49Orphanet, 62UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases
Orphanet: 49 
Rare skin diseases


Aliases & Descriptions:

pemphigoid gestationis 43 49 62
gestational pemphigoid 43
herpes gestationis 43


External Ids:

MESH via Orphanet36 D006559
ICD10 via Orphanet26 L12.8
SNOMED-CT via Orphanet59 86081009
UMLS via Orphanet63 C0019343

Related Diseases for Pemphigoid Gestationis

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17GeneCards, 18GeneDecks
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Diseases related to Pemphigoid Gestationis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 43)
idRelated DiseaseScoreTop Affiliating Genes
1herpes gestationis30.9COL17A1, DST
2bullous pemphigoid30.7DST, CCL11, COL17A1
3cicatricial pemphigoid30.4COL17A1
4pemphigus30.4DST
5pemphigus vulgaris30.2CCL11, DST, HLA-DRB1
6skin disease30.2DST, CCL11, COL17A1
7choriocarcinoma10.5
8dermatitis10.5
9dermatitis herpetiformis10.5
10chorioangioma10.2
11facial hemiatrophy10.2
12gestational diabetes10.2
13cerebritis10.2
14graves' disease10.2
15hellp syndrome10.2
16eosinophilia10.2
17pulmonary embolism10.2
18thrombocytopenia10.2
19linear iga disease10.2
20systemic lupus erythematosus10.2
21lupus erythematosus10.2
22thyrotoxicosis10.2
23ectopic pregnancy10.2
24neonatal herpes10.2
25paraneoplastic syndromes10.2
26junctional epidermolysis bullosa10.1COL17A1
27malaria10.0HLA-DRB1
28epidermolysis bullosa acquisita10.0COL17A1, DST
29junctional epidermolysis bullosa, non-herlitz type10.0COL17A1, DST
30sarcoidosis10.0CCL11, HLA-DRB1
31bullous skin disease10.0COL17A1, DST
32pemphigus foliaceus10.0DST, HLA-DRB1
33epidermolysis bullosa10.0COL17A1, DST
34type 1 diabetes mellitus10.0CCL11, HLA-DRB1
35epidermolysis bullosa simplex10.0COL17A1, DST
36lichen planus10.0COL17A1, DST
37ulcerative colitis10.0HLA-DRB1, CCL11
38multiple sclerosis10.0CCL11, HLA-DRB1
39basal cell carcinoma10.0COL17A1, DST
40galactosemia10.0CCL11, HLA-DRB1
41psoriasis9.9CCL11, DST, HLA-DRB1
42melanoma9.9HLA-DRB1, DST, CCL11
43hypersensitivity reaction type ii disease9.9COL17A1, CCL11, DST, HLA-DRB1

Graphical network of the top 20 diseases related to Pemphigoid Gestationis:



Diseases related to pemphigoid gestationis

Symptoms for Pemphigoid Gestationis

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49Orphanet
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Symptoms:

49
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • prematurity
  • failure to thrive/difficulties for feeding in infancy/growth delay
  • urticaria

Drugs & Therapeutics for Pemphigoid Gestationis

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Pemphigoid Gestationis

Search NIH Clinical Center for Pemphigoid Gestationis

Genetic Tests for Pemphigoid Gestationis

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Anatomical Context for Pemphigoid Gestationis

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33MalaCards
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MalaCards organs/tissues related to Pemphigoid Gestationis:

33
Skin, Placenta, Testes, T cells

Animal Models for Pemphigoid Gestationis or affiliated genes

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Publications for Pemphigoid Gestationis

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52PubMed
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Articles related to Pemphigoid Gestationis:

(show top 50)    (show all 91)
idTitleAuthorsYear
1
A case of pemphigoid gestationis with concurrent IgG antibodies to BP180, BP230 and type VII collagen. (23082779)
2014
2
Pemphigoid gestationis after spontaneous expulsion of a massive complete hydatidiform mole. (24083041)
2013
3
Suspicion of pulmonary embolism during treatment of pemphigoid gestationis. (24278048)
2013
4
Pemphigoid gestationis in a female with progressive facial hemiatrophy: microchimerism as a speculative shared background is disputable. (22535610)
2012
5
Successful treatment of a severe persistent case of pemphigoid gestationis with antepartum and postpartum intravenous immunoglobulin followed by azathioprine. (22309336)
2012
6
Emergency caesarean delivery of a parturient with undiagnosed pemphigoid gestationis. (22626993)
2012
7
Refractory pemphigoid gestationis postpartum. (22360419)
2012
8
Pemphigoid gestationis: pathogenesis and clinical features. (21605810)
2011
9
Pemphigoid gestationis. (21163161)
2010
10
Pemphigoid gestationis: early onset and blister formation are associated with adverse pregnancy outcomes. (19298272)
2009
11
Pemphigoid gestationis: current insights into pathogenesis and treatment. (19520487)
2009
12
Measurement of pruritus in a Chinese woman with pemphigoid gestationis using a wrist movement detector. (18173607)
2008
13
Enzyme-linked immunosorbent assay (ELISA) and indirect immunofluorescence testing in a bullous pemphigoid and pemphigoid gestationis. (19126009)
2008
14
Severe persistent pemphigoid gestationis: long-term remission with rituximab. (17553047)
2007
15
IgG4 as the predominant IgG subclass in pemphigoides gestationis. (16630180)
2006
16
Immunoadsorption against two distinct epitopes on human type XVII collagen abolishes dermal-epidermal separation induced in vitro by autoantibodies from pemphigoid gestationis patients. (16552711)
2006
17
Pemphigoid gestationis: report of a case with umbilical artery Doppler assessment. (16913554)
2006
18
Clinical experience in pemphigoid gestationis: report of 10 cases. (17052488)
2006
19
Herpes gestationis (Pemphigoid gestationis). (16487884)
2006
20
Usefulness of BP180 NC16a enzyme-linked immunosorbent assay in the serodiagnosis of pemphigoid gestationis and in differentiating between pemphigoid gestationis and pruritic urticarial papules and plaques of pregnancy. (15967916)
2005
21
Remarkable follow-up experiences of a severe persistent case of pemphigoid gestationis. (16045710)
2005
22
Pemphigoid gestationis post partum after changing husband. (16409278)
2005
23
T cell receptor gene usage of BP180-specific T lymphocytes from patients with bullous pemphigoid and pemphigoid gestationis. (15451475)
2004
24
Intravenous immune globulin in the treatment of persistent pemphigoid gestationis. (15583609)
2004
25
Tissue eosinophilia in pemphigoid gestationis: association with eotaxin and upregulated activation markers on transmigrated eosinophils. (14725564)
2004
26
The role of T lymphocytes and cytokines in the pathogenesis of pemphigoid gestationis. (12828741)
2003
27
Chronic pemphigoid gestationis: comparative clinical and immunopathological study of 10 patients. (12592077)
2003
28
Pemphigoid gestationis: treatment with immunoapheresis. (16285180)
2003
29
Pemphigoid gestationis: maternal sera recognize epitopes restricted to the N-terminal portion of the extracellular domain of BP180 not present on its shed ectodomain. (12932258)
2003
30
Successful treatment with doxycycline and nicotinamide of two cases of persistent pemphigoid gestationis. (12227878)
2002
31
Pemphigoid gestationis: new insights into the pathogenesis lead to novel diagnostic tools. (12269691)
2002
32
Pemphigoid gestationis with predominant involvement of oral mucous membranes and IgA autoantibodies targeting the C-terminus of BP180. (12399776)
2002
33
A severe persistent case of recurrent pemphigoid gestationis successfully treated with minocycline and nicotinamide. (11722465)
2001
34
Pemphigoid gestationis: a review. (10942491)
2000
35
Pemphigoid gestationis with intra-uterine death associated with foetal cerebral haemorrhage in the mid-trimester. (11012608)
2000
36
Clinical features and management of 87 patients with pemphigoid gestationis. (10457123)
1999
37
IgG1 and IgG3 are the major immunoglobulin subclasses targeting epitopes within the NC16A domain of BP180 in pemphigoid gestationis. (10417635)
1999
38
Class II major histocompatibility complex typing across the ethnic barrier in pemphigoid gestationis. A study in Mexicans. (10065610)
1999
39
A typical case of pemphigoid gestationis with a unique pattern of intercellular immunofluorescence. (9068742)
1997
40
Pemphigoid gestationis with autoantibodies exclusively directed to the 230-kDa bullous pemphigoid antigen (BP230Ag) (8731696)
1996
41
Conversion of pemphigoid gestationis to bullous pemphigoid--two refractory cases highlighting this association. (8915153)
1996
42
Pemphigoid gestationis occurring in a patient with HELLP syndrome. (8687334)
1996
43
Class II MHC typing in pemphigoid gestationis. (8565245)
1995
44
Pemphigoid gestationis and neonatal alloimmune thrombocytopenia. (2189606)
1990
45
Western blot analysis of the antigen in pemphigoid gestationis. (2186774)
1990
46
Antigen-presenting cells in the skin and placenta in pemphigoid gestationis. (2191709)
1990
47
Pemphigoid gestationis: placental interactions. (2701703)
1989
48
Immunopathology of the placenta in pemphigoid gestationis and linear IgA disease. (2667614)
1989
49
The distribution of IgG subclasses in pemphigoid gestationis: PG factor is an IgG1 autoantibody. (2654296)
1989
50
Expression of a pemphigoid gestationis-related antigen by human placenta. (3293646)
1988

Variations for Pemphigoid Gestationis

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Expression for genes affiliated with Pemphigoid Gestationis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pemphigoid Gestationis

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Pathways for genes affiliated with Pemphigoid Gestationis

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50PathCards, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN, 55Reactome
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Compounds for genes affiliated with Pemphigoid Gestationis

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45Novoseek
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Compounds related to Pemphigoid Gestationis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1allergens459.2CCL11, HLA-DRB1
2gold458.8DST, COL17A1
3tyrosine458.8COL17A1, CCL11, HLA-DRB1
4nacl458.5COL17A1, CCL11, DST

GO Terms for genes affiliated with Pemphigoid Gestationis

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16Gene Ontology
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Cellular components related to Pemphigoid Gestationis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basement membraneGO:0056049.1COL17A1, DST
2hemidesmosomeGO:0300568.8COL17A1, DST

Biological processes related to Pemphigoid Gestationis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:0069559.3CCL11, HLA-DRB1
2hemidesmosome assemblyGO:0315819.1COL17A1, DST
3cytoskeleton organizationGO:0070108.9CCL11, DST
4extracellular matrix organizationGO:0301988.8COL17A1, DST

Products for genes affiliated with Pemphigoid Gestationis

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  • Antibodies
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Sources for Pemphigoid Gestationis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet