MCID: PMP002
MIFTS: 29

Pemphigoid Gestationis malady

Skin diseases category

Summaries for Pemphigoid Gestationis

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Pemphigoid gestationis (pg), also known as gestational pemphigoid or herpes gestationis, is an autoimmune skin disorder associated with pregnancy. signs and symptoms of the disorder typically present during the second or third trimester of pregnancy, but it may occur at any time during pregnancy or anywhere up to six weeks after giving birth. although the signs and symptoms are variable, a red, itchy rash with blisters is common. the rash may occur in different parts of the body, but usually develops near the belly button and/or the arms and legs. the condition is caused by the production of antibodies that attack the person's body, leading to damage and consequently blister formation. treatment generally involves systemic corticosteroids.  last updated: 8/11/2010

MalaCards: Pemphigoid Gestationis, also known as gestational pemphigoid, is related to herpes gestationis and bullous pemphigoid, and has symptoms including erythema/erythematous lesions/erythroderma/polymorphous erythema, prematurity and failure to thrive/difficulties for feeding in infancy/growth delay. An important gene associated with Pemphigoid Gestationis is COL17A1 (collagen, type XVII, alpha 1), and among its related pathways are Allograft rejection and Cell-cell junction organization. The compounds gold and allergens have been mentioned in the context of this disorder. Affiliated tissues include skin.

Wikipedia:63 Gestational pemphigoid or pemphigoid gestationis (PG) is a dermatosis of pregnancy, being an autoimmune... more...

Aliases & Classifications for Pemphigoid Gestationis

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Sources:
42NIH Rare Diseases, 48Orphanet, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

pemphigoid gestationis 42 48 60
gestational pemphigoid 42
herpes gestationis 42


External Ids:

MESH via Orphanet35 D006559
ICD10 via Orphanet26 L12.8
SNOMED-CT via Orphanet57 86081009
UMLS via Orphanet61 C0019343

Related Diseases for Pemphigoid Gestationis

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17GeneCards, 18GeneDecks
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Diseases related to Pemphigoid Gestationis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 43)
idRelated DiseaseScoreTop Affiliating Genes
1herpes gestationis30.8DST, COL17A1
2bullous pemphigoid30.8COL17A1, CCL11, DST
3dermatitis herpetiformis30.6CCL11
4dermatitis30.6CCL11
5skin disease30.4CCL11, COL17A1, DST
6pemphigus30.2DST
7cicatricial pemphigoid30.2COL17A1, DST
8bullous skin disease30.1DST, COL17A1
9choriocarcinoma10.4
10hellp syndrome10.2
11facial hemiatrophy10.2
12chorioangioma10.2
13cerebritis10.2
14gestational diabetes10.2
15graves' disease10.2
16eosinophilia10.2
17placenta disease10.2
18pulmonary embolism10.2
19thrombocytopenia10.2
20antiphospholipid syndrome10.1
21systemic lupus erythematosus10.1
22lupus erythematosus10.1
23thyrotoxicosis10.1
24junctional epidermolysis bullosa10.0COL17A1
25nephrotic syndrome10.0CCL11
26eosinophilic esophagitis10.0CCL11
27uveitis10.0CCL11
28leprosy10.0HLA-DRB1
29atopy10.0CCL11
30epidermolysis bullosa acquisita10.0DST, COL17A1
31junctional epidermolysis bullosa, non-herlitz type10.0COL17A1, DST
32epidermolysis bullosa10.0DST, COL17A1
33lichen planus10.0COL17A1, DST
34type 1 diabetes10.0HLA-DRB1, CCL11
35epidermolysis bullosa simplex10.0DST, COL17A1
36multiple sclerosis10.0HLA-DRB1, CCL11
37pemphigus foliaceus10.0DST, HLA-DRB1
38ulcerative colitis10.0HLA-DRB1, CCL11
39basal cell carcinoma10.0DST, COL17A1
40pemphigus vulgaris10.0DST, CCL11, HLA-DRB1
41melanoma10.0CCL11, HLA-DRB1, DST
42psoriasis10.0CCL11, HLA-DRB1, DST
43hypersensitivity reaction type ii disease10.0CCL11, HLA-DRB1, DST, COL17A1

Graphical network of the top 20 diseases related to Pemphigoid Gestationis:



Diseases related to pemphigoid gestationis

Clinical Features for Pemphigoid Gestationis

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Sources:
48Orphanet
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Symptoms:

48
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • prematurity
  • failure to thrive/difficulties for feeding in infancy/growth delay
  • urticaria

Drugs & Therapeutics for Pemphigoid Gestationis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Pemphigoid Gestationis

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Anatomical Context for Pemphigoid Gestationis

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32MalaCards
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MalaCards organs/tissues related to Pemphigoid Gestationis:

32
Skin

Animal Models for Pemphigoid Gestationis or affiliated genes

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Publications for Pemphigoid Gestationis

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Genetic Variations for Pemphigoid Gestationis

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Expression for genes affiliated with Pemphigoid Gestationis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pemphigoid Gestationis

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Pathways for genes affiliated with Pemphigoid Gestationis

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Sources:
29KEGG, 51QIAGEN, 53Reactome, 37NCBI BioSystems Database
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Compounds for genes affiliated with Pemphigoid Gestationis

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44Novoseek
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Compounds related to Pemphigoid Gestationis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1gold449.1DST, COL17A1
2allergens449.0HLA-DRB1, CCL11
3nacl448.4DST, CCL11, COL17A1

GO Terms for genes affiliated with Pemphigoid Gestationis

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16Gene Ontology
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Cellular components related to Pemphigoid Gestationis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basement membraneGO:0056049.1DST, COL17A1
2hemidesmosomeGO:0300568.8DST, COL17A1

Biological processes related to Pemphigoid Gestationis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoskeleton organizationGO:0070109.0DST, CCL11
2hemidesmosome assemblyGO:0315818.8DST, COL17A1

Products for genes affiliated with Pemphigoid Gestationis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pemphigoid Gestationis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet