MCID: PMP002
MIFTS: 34

Pemphigoid Gestationis malady

Rare diseases, Skin diseases categories

Aliases & Classifications for Pemphigoid Gestationis

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Sources:
45NIH Rare Diseases, 51Orphanet, 65UMLS, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all sources

Aliases & Descriptions for Pemphigoid Gestationis:

Name: Pemphigoid Gestationis 45 51 65
Gestational Pemphigoid 45 51
 
Herpes Gestationis 45


Classifications:

Orphanet: 51 
Rare skin diseases


External Ids:

Orphanet51 63275
ICD10 via Orphanet28 L12.8
MESH via Orphanet37 D006559
UMLS via Orphanet66 C0019343

Summaries for Pemphigoid Gestationis

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NIH Rare Diseases:45 Pemphigoid gestationis (pg), also known as gestational pemphigoid or herpes gestationis, is an autoimmune skin disorder associated with pregnancy. signs and symptoms of the disorder typically present during the second or third trimester of pregnancy, but it may occur at any time during pregnancy or anywhere up to six weeks after giving birth. although the signs and symptoms are variable, a red, itchy rash with blisters is common. the rash may occur in different parts of the body, but usually develops near the belly button and/or the arms and legs. the condition is caused by the production of antibodies that attack the person's body, leading to damage and consequently blister formation. treatment generally involves systemic corticosteroids.  last updated: 8/11/2010

MalaCards based summary: Pemphigoid Gestationis, also known as gestational pemphigoid, is related to dermatitis herpetiformis and pemphigus vulgaris, and has symptoms including premature birth, urticaria and erythema/erythematous lesions/erythroderma/polymorphous erythema. An important gene associated with Pemphigoid Gestationis is COL17A1 (Collagen, Type XVII, Alpha 1), and among its related pathways are Alpha6-Beta4 Integrin Signaling Pathway and IL4-mediated signaling events. Affiliated tissues include skin, placenta and t cells.

Wikipedia:68 Gestational pemphigoid or pemphigoid gestationis (PG) is a dermatosis of pregnancy, being an autoimmune... more...

Related Diseases for Pemphigoid Gestationis

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Diseases related to Pemphigoid Gestationis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis herpetiformis30.6CCL11, IL5
2pemphigus vulgaris30.4DST, HLA-DRB1
3herpes gestationis10.7
4bullous pemphigoid10.6
5choriocarcinoma10.5
6dermatitis10.5
7thrombocytopenia10.2
8hellp syndrome10.2
9graves' disease10.2
10cushing's syndrome10.2
11facial hemiatrophy10.2
12pemphigus10.2
13chorioangioma10.2
14cicatricial pemphigoid10.2
15gestational diabetes10.2
16cerebritis10.2
17eosinophilia10.2
18pulmonary embolism10.2
19linear iga disease10.2
20systemic lupus erythematosus10.2
21skin disease10.2
22ectopic pregnancy10.2
23lupus erythematosus10.2
24neonatal herpes10.2
25paraneoplastic syndromes10.2
26lichen planus pigmentosus10.1COL17A1, DST
27linear lichen planus10.1COL17A1, DST
28hard palate cancer10.1COL17A1, DST
29megaesophagus10.1COL17A1, DST
30epidermolysis bullosa, junctional, non-herlitz type10.1COL17A1, DST
31urethral villous adenoma10.1COL17A1, DST
32autoimmune disease of the nervous system10.1COL17A1, DST
33epiglottitis10.1COL17A1, DST
34lip cancer10.1COL17A1, DST
35byssinosis10.1COL17A1, DST
36bullous systemic lupus erythematosus10.1COL17A1, DST
37hereditary retinal dystrophy10.1COL17A1, DST
38spinocerebellar ataxia 3610.1COL17A1, DST
39vestibular disease10.1COL17A1, DST
40plexiform schwannoma10.1COL17A1, DST
41basal ganglia cerebrovascular disease10.1CCL11, IL5
42chronic myeloproliferative disease10.1CCL11, IL5
43coenurosis10.1CCL11, IL5
44esophagitis, eosinophilic, 110.1CCL11, IL5
45periodic limb movement disorder10.1COL17A1, DST
46acute apical periodontitis10.1CCL11, IL5
47barre-lieou syndrome10.1CCL11, IL5
48thalamic neoplasm10.1CCL11, IL5
49axillary adenitis10.1COL17A1, DST
50loeffler syndrome10.1CCL11, IL5

Graphical network of the top 20 diseases related to Pemphigoid Gestationis:



Diseases related to pemphigoid gestationis

Symptoms for Pemphigoid Gestationis

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Symptoms:

 51
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • prematurity
  • failure to thrive/difficulties for feeding in infancy/growth delay
  • urticaria

HPO human phenotypes related to Pemphigoid Gestationis:

id Description Frequency HPO Source Accession
1 premature birth hallmark (90%) HP:0001622
2 urticaria occasional (7.5%) HP:0001025

Drugs & Therapeutics for Pemphigoid Gestationis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Pemphigoid Gestationis

Genetic Tests for Pemphigoid Gestationis

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Anatomical Context for Pemphigoid Gestationis

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MalaCards organs/tissues related to Pemphigoid Gestationis:

33
Skin, Placenta, T cells, Testes

Animal Models for Pemphigoid Gestationis or affiliated genes

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Publications for Pemphigoid Gestationis

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Articles related to Pemphigoid Gestationis:

(show top 50)    (show all 107)
idTitleAuthorsYear
1
Pemphigoid gestationis revealing a denial of pregnancy. (26299950)
2015
2
Positive clinical outcome with IVIg as monotherapy in recurrent pemphigoid gestationis. (25765353)
2015
3
What is your diagnosis? pemphigoid gestationis (herpes gestationis). (26057509)
2015
4
Pemphigoid Gestationis: A Case Report and Review of Management. (26267738)
2015
5
A case of pemphigoid gestationis with concurrent IgG antibodies to BP180, BP230 and type VII collagen. (23082779)
2014
6
Recognizing presentations of pemphigoid gestationis: a case study. (25506008)
2014
7
Pemphigoid gestationis with prepartum flare. (25039537)
2014
8
Pemphigoid gestationis (herpes gestationis). (25404804)
2014
9
Successfully treated case of pemphigoid gestationis with post-partum intravenous and oral steroids. (25404796)
2014
10
Intravenous Immunoglobulin Therapy for Persistent Pemphigoid Gestationis with Steroid Induced Iatrogenic Cushing's Syndrome. (25324672)
2014
11
Pemphigoid gestationis after spontaneous expulsion of a massive complete hydatidiform mole. (24083041)
2013
12
Pemphigoid gestationis with postpartum flare-up: a case report. (24568052)
2013
13
Pemphigoid gestationis in a female with progressive facial hemiatrophy: microchimerism as a speculative shared background is disputable. (22535610)
2012
14
Successful treatment of a severe persistent case of pemphigoid gestationis with antepartum and postpartum intravenous immunoglobulin followed by azathioprine. (22309336)
2012
15
Emergency caesarean delivery of a parturient with undiagnosed pemphigoid gestationis. (22626993)
2012
16
Refractory pemphigoid gestationis postpartum. (22360419)
2012
17
Pemphigoid gestationis: pathogenesis and clinical features. (21605810)
2011
18
Pemphigoid gestationis. (21163161)
2010
19
Pemphigoid gestationis: early onset and blister formation are associated with adverse pregnancy outcomes. (19298272)
2009
20
Measurement of pruritus in a Chinese woman with pemphigoid gestationis using a wrist movement detector. (18173607)
2008
21
Enzyme-linked immunosorbent assay (ELISA) and indirect immunofluorescence testing in a bullous pemphigoid and pemphigoid gestationis. (19126009)
2008
22
Severe persistent pemphigoid gestationis: long-term remission with rituximab. (17553047)
2007
23
IgG4 as the predominant IgG subclass in pemphigoides gestationis. (16630180)
2006
24
Immunoadsorption against two distinct epitopes on human type XVII collagen abolishes dermal-epidermal separation induced in vitro by autoantibodies from pemphigoid gestationis patients. (16552711)
2006
25
Usefulness of BP180 NC16a enzyme-linked immunosorbent assay in the serodiagnosis of pemphigoid gestationis and in differentiating between pemphigoid gestationis and pruritic urticarial papules and plaques of pregnancy. (15967916)
2005
26
Remarkable follow-up experiences of a severe persistent case of pemphigoid gestationis. (16045710)
2005
27
Pemphigoid gestationis post partum after changing husband. (16409278)
2005
28
T cell receptor gene usage of BP180-specific T lymphocytes from patients with bullous pemphigoid and pemphigoid gestationis. (15451475)
2004
29
Intravenous immune globulin in the treatment of persistent pemphigoid gestationis. (15583609)
2004
30
Tissue eosinophilia in pemphigoid gestationis: association with eotaxin and upregulated activation markers on transmigrated eosinophils. (14725564)
2004
31
The role of T lymphocytes and cytokines in the pathogenesis of pemphigoid gestationis. (12828741)
2003
32
Chronic pemphigoid gestationis: comparative clinical and immunopathological study of 10 patients. (12592077)
2003
33
Pemphigoid gestationis: treatment with immunoapheresis. (16285180)
2003
34
Pemphigoid gestationis: maternal sera recognize epitopes restricted to the N-terminal portion of the extracellular domain of BP180 not present on its shed ectodomain. (12932258)
2003
35
Successful treatment with doxycycline and nicotinamide of two cases of persistent pemphigoid gestationis. (12227878)
2002
36
Pemphigoid gestationis: new insights into the pathogenesis lead to novel diagnostic tools. (12269691)
2002
37
A severe persistent case of recurrent pemphigoid gestationis successfully treated with minocycline and nicotinamide. (11722465)
2001
38
Pemphigoid gestationis: a review. (10942491)
2000
39
Pemphigoid gestationis with intra-uterine death associated with foetal cerebral haemorrhage in the mid-trimester. (11012608)
2000
40
Clinical features and management of 87 patients with pemphigoid gestationis. (10457123)
1999
41
IgG1 and IgG3 are the major immunoglobulin subclasses targeting epitopes within the NC16A domain of BP180 in pemphigoid gestationis. (10417635)
1999
42
A typical case of pemphigoid gestationis with a unique pattern of intercellular immunofluorescence. (9068742)
1997
43
Pemphigoid gestationis with autoantibodies exclusively directed to the 230-kDa bullous pemphigoid antigen (BP230Ag) (8731696)
1996
44
Class II MHC typing in pemphigoid gestationis. (8565245)
1995
45
Pemphigoid gestationis and neonatal alloimmune thrombocytopenia. (2189606)
1990
46
Western blot analysis of the antigen in pemphigoid gestationis. (2186774)
1990
47
Antigen-presenting cells in the skin and placenta in pemphigoid gestationis. (2191709)
1990
48
Pemphigoid gestationis: placental interactions. (2701703)
1989
49
Immunopathology of the placenta in pemphigoid gestationis and linear IgA disease. (2667614)
1989
50
Expression of a pemphigoid gestationis-related antigen by human placenta. (3293646)
1988

Variations for Pemphigoid Gestationis

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Expression for genes affiliated with Pemphigoid Gestationis

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Search GEO for disease gene expression data for Pemphigoid Gestationis.

Pathways for genes affiliated with Pemphigoid Gestationis

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GO Terms for genes affiliated with Pemphigoid Gestationis

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Cellular components related to Pemphigoid Gestationis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hemidesmosomeGO:00300569.6COL17A1, DST
2basement membraneGO:00056049.5COL17A1, DST

Biological processes related to Pemphigoid Gestationis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hemidesmosome assemblyGO:00315819.8COL17A1, DST
2cytoskeleton organizationGO:00070109.3CCL11, DST
3immune responseGO:00069558.5CCL11, HLA-DRB1, IL5

Sources for Pemphigoid Gestationis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet