MCID: PMP002
MIFTS: 34

Pemphigoid Gestationis malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Pemphigoid Gestationis

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Sources:
30ICD10 via Orphanet, 39MESH via Orphanet, 47NIH Rare Diseases, 53Orphanet, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Pemphigoid Gestationis:

Name: Pemphigoid Gestationis 47 53 67
Gestational Pemphigoid 47 53
 
Herpes Gestationis 47

Classifications:

Orphanet: 53 
Rare skin diseases


External Ids:

Orphanet53 ORPHA63275
ICD10 via Orphanet30 L12.8
UMLS via Orphanet68 C0019343
MESH via Orphanet39 D006559

Summaries for Pemphigoid Gestationis

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Wikipedia:70 Gestational pemphigoid or pemphigoid gestationis (PG) is a dermatosis of pregnancy, being an autoimmune... more...

MalaCards based summary: Pemphigoid Gestationis, also known as gestational pemphigoid, is related to herpes gestationis and lichen sclerosus, and has symptoms including premature birth, urticaria and Array. An important gene associated with Pemphigoid Gestationis is COL17A1 (Collagen Type XVII Alpha 1 Chain), and among its related pathways are Alpha6-Beta4 Integrin Signaling Pathway and IL4-mediated signaling events. Affiliated tissues include skin, placenta and t cells.

Related Diseases for Pemphigoid Gestationis

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Diseases related to Pemphigoid Gestationis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1herpes gestationis12.0
2lichen sclerosus10.3COL17A1, DST
3submandibular gland cancer10.3COL17A1, DST
4microcephaly, holoprosencephaly, and intrauterine growth retardation10.3COL17A1, DST
5gilbert syndrome10.2COL17A1, DST
6impetigo10.2COL17A1, DST
7malignant histiocytosis10.2COL17A1, DST
8puerperal pulmonary embolism10.2COL17A1, DST
9tinea cruris10.2COL17A1, DST
10demyelinating disease10.2COL17A1, DST
11sporotrichosis10.2COL17A1, DST
12quinquaud's decalvans folliculitis10.2COL17A1, HLA-DRB1
13bullous pemphigoid10.1
14familial retinoblastoma10.1COL17A1, DST
15geniculate herpes zoster10.1COL17A1, DST
16peri-anal fistula10.1DST, HLA-DRB1
17blood group incompatibility10.1COL17A1, DST
18borst-jadassohn intraepidermal carcinoma10.1CCL11, HLA-DRB1
19iridocyclitis10.0CCL11, HLA-DRB1
20skin atrophy10.0COL17A1, DST
21solitary cyst of breast10.0CCL11, IL5
22cholesteatoma of middle ear9.9CCL11, IL5
23fungal gastritis9.9CCL11, IL5
24vibrio vulnificus infection9.9CCL11, IL5
25pruritic urticarial papules and plaques of pregnancy9.9
26pemphigus vulgaris9.9
27pemphigus9.9
28antley-bixler syndrome with genital anomalies and disordered steroidogenesis9.9CCL11, IL5
29benign mammary dysplasia9.9CCL11, IL5
30dioctophymiasis9.9CCL11, IL5
31epididymis adenocarcinoma9.9CCL11, IL5
32bacterial gastritis9.9CCL11, IL5
33apple allergy9.9CCL11, IL5
34cervix melanoma9.9CCL11, IL5
35central nervous system origin vertigo9.9CCL11, IL5
36pituitary hypoplasia9.9CCL11, IL5
37dacryoadenitis9.9CCL11, IL5
38gait apraxia9.9CCL11, IL5
39buphthalmos9.9CCL11, IL5
40melanoacanthoma9.9CCL11, IL5
41vaginitis9.9CCL11, IL5
42geotrichosis9.9CCL11, IL5
43dentin caries9.9CCL11, IL5
44small non-cleaved cell lymphoma9.9COL17A1, DST
45sarcoid meningitis9.9CCL11, IL5
46biliary tract disease9.9CCL11, IL5
47loeffler syndrome9.9CCL11, IL5
48purpura fulminans9.8HLA-DRB1, IL5
49synostosis9.8CCL11, IL5
50exophthalmos9.8CCL11, IL5

Graphical network of the top 20 diseases related to Pemphigoid Gestationis:



Diseases related to pemphigoid gestationis

Symptoms for Pemphigoid Gestationis

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Human phenotypes related to Pemphigoid Gestationis:

 63 53 (show all 7)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 premature birth63 53 hallmark (90%) Very frequent (99-80%) HP:0001622
2 urticaria63 occasional (7.5%) HP:0001025
3 pruritus53 Very frequent (99-80%)
4 failure to thrive53 Frequent (79-30%)
5 intrauterine growth retardation53 Frequent (79-30%)
6 abnormal blistering of the skin53 Very frequent (99-80%)
7 skin vesicle53 Very frequent (99-80%)

UMLS symptoms related to Pemphigoid Gestationis:


hyperemesis gravidarum, morning sickness, coma blister

Drugs & Therapeutics for Pemphigoid Gestationis

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Genetic Susceptibility and Influence of the Microbiomae in Bullous PemphigoidRecruitingNCT02874079

Search NIH Clinical Center for Pemphigoid Gestationis

Genetic Tests for Pemphigoid Gestationis

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Anatomical Context for Pemphigoid Gestationis

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MalaCards organs/tissues related to Pemphigoid Gestationis:

35
Skin, Placenta, T cells, Testes

Animal Models for Pemphigoid Gestationis or affiliated genes

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Publications for Pemphigoid Gestationis

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Articles related to Pemphigoid Gestationis:

(show top 50)    (show all 117)
idTitleAuthorsYear
1
Pemphigoid gestationis: a successful preventive treatment by rituximab. (27606493)
2016
2
Concomitant pemphigus vulgaris and pemphigoid gestationis: a case report and review of the literature. (26990471)
2016
3
Lichen planus pemphigoides associated with pregnancy mimicking pemphigoid gestationis. (27416093)
2016
4
Successful treatment of a severe early onset case of pemphigoid gestationis with intravenous immunoglobulin in a twin pregnancy conceived with in vitro fertilisation in a primigravida. (27922278)
2016
5
Pemphigoid gestationis revealing a denial of pregnancy. (26299950)
2015
6
Pemphigoid gestationis. (25581583)
2015
7
Pemphigoid gestationis with prepartum flare. (25039537)
2014
8
Pemphigoid gestationis (herpes gestationis). (25404804)
2014
9
Successfully treated case of pemphigoid gestationis with post-partum intravenous and oral steroids. (25404796)
2014
10
Clinical and immunological profiles of 25 patients with pemphigoid gestationis. (25154546)
2014
11
Pemphigoid gestationis in a third trimester pregnancy. (25431712)
2014
12
Case for diagnosis. Pemphigoid gestationis. (24626668)
2014
13
The utility of C4d immunohistochemistry on formalin-fixed paraffin-embedded tissue in the distinction of polymorphic eruption of pregnancy from pemphigoid gestationis. (24061402)
2013
14
Pemphigoid gestationis. (24365006)
2013
15
Pemphigoid gestationis in a female with progressive facial hemiatrophy: microchimerism as a speculative shared background is disputable. (22535610)
2012
16
Pemphigoid gestationis. (22715180)
2011
17
Pemphigoid gestationis: current management. (21925007)
2011
18
No evidence for fetal microchimerism in the skin of patients with pemphigoid gestationis. (19840915)
2010
19
Pemphigoid gestationis: current insights into pathogenesis and treatment. (19520487)
2009
20
Measurement of pruritus in a Chinese woman with pemphigoid gestationis using a wrist movement detector. (18173607)
2008
21
Pemphigoid gestationis autoantigen, transmembrane collagen XVII, promotes the migration of cytotrophoblastic cells of placenta and is a structural component of fetal membranes. (18055190)
2008
22
Normal neonatal outcome in a Chinese woman with pemphigoid gestationis, Graves' disease, and history of placental chorioangioma. (17822510)
2007
23
The intracellular and extracellular domains of BP180 antigen comprise novel epitopes targeted by pemphigoid gestationis autoantibodies. (17068480)
2007
24
Pemphigoid gestationis: report of a case with umbilical artery Doppler assessment. (16913554)
2006
25
Remarkable follow-up experiences of a severe persistent case of pemphigoid gestationis. (16045710)
2005
26
A case of gestational diabetes arising following treatment with glucocorticosteroids for pemphigoid gestationis. (16390798)
2005
27
Intravenous immune globulin in the treatment of persistent pemphigoid gestationis. (15583609)
2004
28
Tissue eosinophilia in pemphigoid gestationis: association with eotaxin and upregulated activation markers on transmigrated eosinophils. (14725564)
2004
29
The role of T lymphocytes and cytokines in the pathogenesis of pemphigoid gestationis. (12828741)
2003
30
Pemphigoid gestationis: maternal sera recognize epitopes restricted to the N-terminal portion of the extracellular domain of BP180 not present on its shed ectodomain. (12932258)
2003
31
Pemphigoid gestationis: new insights into the pathogenesis lead to novel diagnostic tools. (12269691)
2002
32
Pemphigoid gestationis: a review. (10942491)
2000
33
Pemphigoid gestationis without blisters]. (10663036)
2000
34
Clinical features and management of 87 patients with pemphigoid gestationis. (10457123)
1999
35
IgG1 and IgG3 are the major immunoglobulin subclasses targeting epitopes within the NC16A domain of BP180 in pemphigoid gestationis. (10417635)
1999
36
A severe persistent case of pemphigoid gestationis treated with intravenous immunoglobulins and cyclosporin. (9894365)
1998
37
Pemphigoid gestationis with autoantibodies exclusively directed to the 230-kDa bullous pemphigoid antigen (BP230Ag) (8731696)
1996
38
Conversion of pemphigoid gestationis to bullous pemphigoid--two refractory cases highlighting this association. (8915153)
1996
39
Class II MHC typing in pemphigoid gestationis. (8565245)
1995
40
Anti-HLA antibodies in pemphigoid gestationis (herpes gestationis). (8286221)
1993
41
Isolated basal keratinocytes express pemphigoid gestationis antigen. (1536760)
1992
42
Pemphigoid gestationis--response to chemical oophorectomy with goserelin. (1486714)
1992
43
Pemphigoid gestationis and neonatal alloimmune thrombocytopenia. (2189606)
1990
44
Antigen-presenting cells in the skin and placenta in pemphigoid gestationis. (2191709)
1990
45
Pemphigoid gestationis: placental interactions. (2701703)
1989
46
Immunopathology of the placenta in pemphigoid gestationis and linear IgA disease. (2667614)
1989
47
The distribution of IgG subclasses in pemphigoid gestationis: PG factor is an IgG1 autoantibody. (2654296)
1989
48
Pemphigoid gestationis: a unique mechanism of initiation of an autoimmune response by MHC class II molecules? (2666624)
1989
49
Expression of a pemphigoid gestationis-related antigen by human placenta. (3293646)
1988
50
Abnormal expression of HLA-DR antigen in the placenta of a patient with pemphigoid gestationis. (6394752)
1984

Variations for Pemphigoid Gestationis

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Expression for genes affiliated with Pemphigoid Gestationis

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Search GEO for disease gene expression data for Pemphigoid Gestationis.

Pathways for genes affiliated with Pemphigoid Gestationis

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GO Terms for genes affiliated with Pemphigoid Gestationis

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Cellular components related to Pemphigoid Gestationis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hemidesmosomeGO:00300569.6COL17A1, DST
2basement membraneGO:00056049.5COL17A1, DST

Sources for Pemphigoid Gestationis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet