MCID: PMP002
MIFTS: 36

Pemphigoid Gestationis

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Pemphigoid Gestationis

MalaCards integrated aliases for Pemphigoid Gestationis:

Name: Pemphigoid Gestationis 50 56 69
Gestational Pemphigoid 50 56
Herpes Gestationis 50

Classifications:

Orphanet: 56  
Rare skin diseases


External Ids:

Orphanet 56 ORPHA63275
MESH via Orphanet 43 D006559
UMLS via Orphanet 70 C0019343
ICD10 via Orphanet 34 L12.8

Summaries for Pemphigoid Gestationis

NIH Rare Diseases : 50 pemphigoid gestationis (pg) is a pregnancy-associated autoimmune skin disorder. it usually begins abruptly during the 2nd or 3rd trimester of pregnancy, but can occur any time during pregnancy. signs and symptoms often include the formation of very itchy, red bumps and/or blisters on the abdomen and trunk, but other parts of the body can be affected. unrelenting itchiness (pruritus) often interferes with daily activities. symptoms may improve at the end of pregnancy, but flares may occur during, or right after, delivery. while it usually goes away on its own within weeks to months after delivery, it may recur during menses; with use of oral contraceptives; and/or with subsequent pregnancies. pg is caused by a woman's immune system mistakenly attacking her own skin, but the exact reasons why this occurs is poorly understood. treatment depends on severity and may include topical corticosteroids; oral corticosteroids, and/or oral antihistamines to relieve itching. last updated: 5/3/2016

MalaCards based summary : Pemphigoid Gestationis, also known as gestational pemphigoid, is related to herpes gestationis and ligneous conjunctivitis, and has symptoms including pruritus, failure to thrive and intrauterine growth retardation. An important gene associated with Pemphigoid Gestationis is COL17A1 (Collagen Type XVII Alpha 1 Chain), and among its related pathways/superpathways are Allograft rejection and Hematopoietic cell lineage. Affiliated tissues include skin, placenta and t cells.

Wikipedia : 72 Gestational pemphigoid or pemphigoid gestationis (PG) is a dermatosis of pregnancy, being an autoimmune... more...

Related Diseases for Pemphigoid Gestationis

Diseases related to Pemphigoid Gestationis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
id Related Disease Score Top Affiliating Genes
1 herpes gestationis 11.9
2 ligneous conjunctivitis 10.4 COL17A1 DST
3 lip and oral cavity cancer 10.4 COL17A1 DST
4 rectum carcinoma in situ 10.4 COL17A1 DST
5 nemaline myopathy 9 10.3 COL17A1 DST
6 autism spectrum disorder 10.3 COL17A1 DST
7 bilirubin metabolic disorder 10.3 COL17A1 DST
8 epidermolysis bullosa simplex, ogna type 10.3 COL17A1 DST
9 pilar sheath acanthoma 10.3 COL17A1 DST
10 nephrosclerosis 10.3 COL17A1 DST
11 acute vascular insufficiency of intestine 10.3 COL17A1 DST
12 peripheral nervous system neoplasm 10.3 COL17A1 DST
13 acute pulmonary heart disease 10.3 COL17A1 DST
14 jejunal somatostatinoma 10.3 COL17A1 DST
15 ureteral lymphoma 10.3 COL17A1 DST
16 epidermolysis bullosa, junctional, non-herlitz type 10.3 COL17A1 DST
17 light chain deposition disease 10.3 COL17A1 HLA-DRB1
18 bilateral retinoblastoma 10.2 COL17A1 DST
19 central sleep apnea 10.2 COL17A1 DST
20 peri-anal fistula 10.2 DST HLA-DRB1
21 dyskinesia of esophagus 10.2 COL17A1 DST
22 bullous pemphigoid 10.1
23 peripheral t-cell lymphoma 10.1 DST HLA-DRB1
24 gilbert syndrome 10.1 COL17A1 DST
25 solitary cyst of breast 10.0 CCL11 IL5
26 dioctophymiasis 10.0 CCL11 IL5
27 cholesteatoma of middle ear 10.0 CCL11 IL5
28 epididymis adenocarcinoma 10.0 CCL11 IL5
29 antley-bixler syndrome with genital anomalies and disordered steroidogenesis 10.0 CCL11 IL5
30 apple allergy 10.0 CCL11 IL5
31 lymphocytic gastritis 10.0 CCL11 IL5
32 cannabis abuse 10.0 CCL11 IL5
33 fungal gastritis 10.0 CCL11 IL5
34 trachea leiomyoma 10.0 CCL11 IL5
35 female urethral cancer 10.0 CCL11 IL5
36 fibrous histiocytoma 10.0 CCL11 IL5
37 viljoen kallis voges syndrome 10.0 CCL11 IL5
38 myofascial pain syndrome 10.0 CCL11 IL5
39 angiomyoma 10.0 CCL11 IL5
40 leukocyte disease 9.9 CCL11 IL5
41 endocardium cancer 9.9 CCL11 IL5
42 pruritic urticarial papules and plaques of pregnancy 9.9
43 pemphigus vulgaris 9.9
44 pemphigus 9.9
45 inflamed seborrheic keratosis 9.9 CCL11 IL5
46 eyelid neoplasm 9.9 CCL11 IL5
47 acute contagious conjunctivitis 9.9 CCL11 IL5
48 dehydration polycythemia 9.9 CCL11 IL5
49 pelvic varices 9.9 CCL11 IL5
50 dentin caries 9.9 CCL11 IL5

Graphical network of the top 20 diseases related to Pemphigoid Gestationis:



Diseases related to Pemphigoid Gestationis

Symptoms & Phenotypes for Pemphigoid Gestationis

Human phenotypes related to Pemphigoid Gestationis:

56 32 (show all 6)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pruritus 56 32 hallmark (90%) Very frequent (99-80%) HP:0000989
2 failure to thrive 56 32 frequent (33%) Frequent (79-30%) HP:0001508
3 intrauterine growth retardation 56 32 frequent (33%) Frequent (79-30%) HP:0001511
4 premature birth 56 32 hallmark (90%) Very frequent (99-80%) HP:0001622
5 abnormal blistering of the skin 56 32 hallmark (90%) Very frequent (99-80%) HP:0008066
6 skin vesicle 56 32 hallmark (90%) Very frequent (99-80%) HP:0200037

UMLS symptoms related to Pemphigoid Gestationis:


morning sickness

Drugs & Therapeutics for Pemphigoid Gestationis

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Genetic Susceptibility and Influence of the Microbiomae in Bullous Pemphigoid Recruiting NCT02874079

Search NIH Clinical Center for Pemphigoid Gestationis

Genetic Tests for Pemphigoid Gestationis

Anatomical Context for Pemphigoid Gestationis

MalaCards organs/tissues related to Pemphigoid Gestationis:

39
Skin, Placenta, T Cells, Testes

Publications for Pemphigoid Gestationis

Articles related to Pemphigoid Gestationis:

(show top 50) (show all 122)
id Title Authors Year
1
Early flare-up of severe Herpes gestationis (Pemphigoid gestationis) and successfull prolonged treatment: A case report. ( 28399702 )
2017
2
Image Gallery: Pemphigoid gestationis mimicking a gyrate erythema. ( 28418130 )
2017
3
Severe pemphigoid gestationis associated with acute disseminated encephalomyelitis in the setting of a systemic disorder. ( 28524368 )
2017
4
Pemphigoid gestationis: Clinical and histologic features of twenty-three patients. ( 28560301 )
2017
5
Sensitivity and specificity of BP180 NC16A enzyme-linked immunosorbent assay for the diagnosis of pemphigoid gestationis. ( 28212762 )
2017
6
Concomitant pemphigus vulgaris and pemphigoid gestationis: a case report and review of the literature. ( 26990471 )
2016
7
New Technology Identifies Pemphigoid Gestationis by Detection of Anti-BP180 IgG, but Simultaneous Detection of Anti-BP230 IgG does not Improve Diagnosis. ( 27174635 )
2016
8
Retrospective analysis of pemphigoid gestationis in 32 Saudi patients - Clinicopathological features and a literature review. ( 27175516 )
2016
9
Lichen planus pemphigoides associated with pregnancy mimicking pemphigoid gestationis. ( 27416093 )
2016
10
Successful treatment of a severe early onset case of pemphigoid gestationis with intravenous immunoglobulin in a twin pregnancy conceived with in vitro fertilisation in a primigravida. ( 27922278 )
2016
11
Pemphigoid gestationis: Toward a better understanding of the etiopathogenesis. ( 27265076 )
2016
12
Pregnancy with Pemphigoid Gestationis: A Rare Entity. ( 27630915 )
2016
13
Pemphigoid gestationis: a successful preventive treatment by rituximab. ( 27606493 )
2016
14
What is your diagnosis? pemphigoid gestationis (herpes gestationis). ( 26057509 )
2015
15
Pemphigoid gestationis. ( 25581583 )
2015
16
Dermatological Diseases Associated with Pregnancy: Pemphigoid Gestationis, Polymorphic Eruption of Pregnancy, Intrahepatic Cholestasis of Pregnancy, and Atopic Eruption of Pregnancy. ( 26609305 )
2015
17
Pemphigoid Gestationis: A Case Report and Review of Management. ( 26267738 )
2015
18
Positive clinical outcome with IVIg as monotherapy in recurrent pemphigoid gestationis. ( 25765353 )
2015
19
A severe and prolonged case of pemphigoid gestationis successfully treated with combination therapies. ( 26521896 )
2015
20
Pemphigoid gestationis revealing a denial of pregnancy. ( 26299950 )
2015
21
Pemphigoid Gestationis Complicating an Egg Donation Pregnancy. ( 26608214 )
2015
22
Pemphigoid gestationis with IgG autoantibodies to both the 120A kDa LAD-1 and the BP180 NC16a domain. ( 25547184 )
2014
23
Pemphigoid gestationis with prepartum flare. ( 25039537 )
2014
24
Pemphigoid gestationis (herpes gestationis). ( 25404804 )
2014
25
Pemphigoid gestationis in a third trimester pregnancy. ( 25431712 )
2014
26
Intravenous Immunoglobulin Therapy for Persistent Pemphigoid Gestationis with Steroid Induced Iatrogenic Cushing's Syndrome. ( 25324672 )
2014
27
Case for diagnosis. Pemphigoid gestationis. ( 24626668 )
2014
28
Successfully treated case of pemphigoid gestationis with post-partum intravenous and oral steroids. ( 25404796 )
2014
29
A case of pemphigoid gestationis with concurrent IgG antibodies to BP180, BP230 and type VII collagen. ( 23082779 )
2014
30
Clinical and immunological profiles of 25 patients with pemphigoid gestationis. ( 25154546 )
2014
31
Recognizing presentations of pemphigoid gestationis: a case study. ( 25506008 )
2014
32
Pemphigoid gestationis: a retrospective study in southwest Iran. ( 23852847 )
2013
33
Pemphigoid gestationis after spontaneous expulsion of a massive complete hydatidiform mole. ( 24083041 )
2013
34
Pemphigoid gestationis. ( 24365006 )
2013
35
Pemphigoid gestationis with postpartum flare-up: a case report. ( 24568052 )
2013
36
Dyshidrosiform presentation (pompholyx-like) of pemphigoid gestationis with intrauterine fetal death. ( 23432199 )
2013
37
Pemphigoid gestationis. ( 24007701 )
2013
38
Suspicion of pulmonary embolism during treatment of pemphigoid gestationis. ( 24278048 )
2013
39
The utility of C4d immunohistochemistry on formalin-fixed paraffin-embedded tissue in the distinction of polymorphic eruption of pregnancy from pemphigoid gestationis. ( 24061402 )
2013
40
Pemphigoid gestationis with a complete hydatidiform mole. ( 21950371 )
2012
41
Emergency caesarean delivery of a parturient with undiagnosed pemphigoid gestationis. ( 22626993 )
2012
42
Glucocorticosteroid-resistant pemphigoid gestationis: successful treatment with adjuvant immunoadsorption. ( 22379622 )
2012
43
Postpartum pemphigoid gestationis. ( 22615518 )
2012
44
Pemphigoid gestationis in a female with progressive facial hemiatrophy: microchimerism as a speculative shared background is disputable. ( 22535610 )
2012
45
Successful treatment of a severe persistent case of pemphigoid gestationis with antepartum and postpartum intravenous immunoglobulin followed by azathioprine. ( 22309336 )
2012
46
Pemphigoid gestationis. ( 22137226 )
2012
47
Refractory pemphigoid gestationis postpartum. ( 22360419 )
2012
48
Successful immunoapheresis of bullous autoimmune diseases: pemphigus vulgaris and pemphigoid gestationis. ( 20812992 )
2011
49
Pemphigoid gestationis. ( 22715180 )
2011
50
Pemphigoid gestationis: a case report and review of the literature. ( 21877502 )
2011

Variations for Pemphigoid Gestationis

Expression for Pemphigoid Gestationis

Search GEO for disease gene expression data for Pemphigoid Gestationis.

Pathways for Pemphigoid Gestationis

GO Terms for Pemphigoid Gestationis

Cellular components related to Pemphigoid Gestationis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 basement membrane GO:0005604 8.96 COL17A1 DST
2 hemidesmosome GO:0030056 8.62 COL17A1 DST

Biological processes related to Pemphigoid Gestationis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 8.8 CCL11 HLA-DRB1 IL5

Sources for Pemphigoid Gestationis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....