MCID: PMP001
MIFTS: 50

Pemphigus malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Pemphigus

Aliases & Descriptions for Pemphigus:

Name: Pemphigus 12 50 52 41 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9182
ICD10 33 L10 L10.9
ICD9CM 35 694.4
MeSH 42 D010392
NCIt 47 C34909
UMLS 69 C0030807

Summaries for Pemphigus

NIH Rare Diseases : 50 pemphigus is a group of rare autoimmune diseases that cause blistering of the skin and mucous membranes (mouth, nose, throat, eyes, and genitals). this condition can occur at any age, but often strikes people in middle or older age. studies have shown that some populations may be at greater risk for certain types of pemphigus. for instance, people of jewish descent and those from india, southeast europe, and the middle east are at greater risk for pemphigus vulargis, while pemphigus foliaceus is more common in north america, turkey, and south america. pemphigus is a chronic disease which is best controlled by early diagnosis and treatment. treatment includes steroids to reduce inflammation, drugs that suppress the immune system response and antibiotics to treat associated infections. there are four main types of pemphigus: pemphigus vulgaris pemphigus foliaceus iga pemphigus paraneoplastic pemphigus last updated: 8/12/2016

MalaCards based summary : Pemphigus is related to epidermolysis bullosa, lethal acantholytic and herpes zoster, and has symptoms including exanthema and pruritus. An important gene associated with Pemphigus is DSG3 (Desmoglein 3), and among its related pathways/superpathways are Developmental Biology and Keratinization. The drugs Cyclophosphamide and rituximab have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and t cells, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and integument

MedlinePlus : 41 pemphigus is an autoimmune disorder. if you have it, your immune system attacks healthy cells in your skin and mouth, causing blisters and sores. no one knows the cause. pemphigus does not spread from person to person. it does not appear to be inherited. but some people's genes put them more at risk for pemphigus. pemphigoid is also an autoimmune skin disease. it leads to deep blisters that do not break easily. pemphigoid is most common in older adults and may be fatal for older, sick patients. doctors diagnose pemphigus with a physical exam, a biopsy, and blood tests. the treatment of pemphigus and pemphigoid is the same: one or more medicines to control symptoms. these may include steroids, which reduce inflammation drugs that suppress the immune system response antibiotics to treat associated infections nih: national institute of arthritis and musculoskeletal and skin diseases

Wikipedia : 71 Pemphigus (/ˈpɛmfɪɡəs/ or /pɛmˈfaɪɡəs/) is a rare group of blistering autoimmune diseases that... more...

Related Diseases for Pemphigus

Diseases related to Pemphigus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 287)
id Related Disease Score Top Affiliating Genes
1 epidermolysis bullosa, lethal acantholytic 31.4 DSP JUP
2 herpes zoster 27.9 CD79A COL17A1 DSC1 DSC3 DSG1 DSG3
3 pompholyx 26.3 A2ML1 ATP2C1 CD79A COL17A1 DSC1 DSC3
4 pemphigus vulgaris 12.5
5 pemphigus foliaceus 12.3
6 pemphigus erythematosus 12.3
7 pemphigus vegetans 12.3
8 paraneoplastic pemphigus 12.3
9 pemphigus vulgaris, familial 12.2
10 pemphigus and fogo selvagem 12.1
11 hailey-hailey disease 12.0
12 herpetiform pemphigus 12.0
13 cicatricial pemphigoid 11.5
14 bullous pemphigoid 11.3
15 ritter's disease 10.9
16 x-linked intellectual disability-precocious puberty-obesity syndrome 10.3 DSG3 DSP
17 cardiomyopathy, dilated, 1bb 10.3 DSG1 DSP
18 pneumonia caused by pseudomonas aeruginosa infection 10.3 DSG1 DSP
19 immunodeficiency by defective expression of hla class 1 10.2 DSG1 DSG3
20 branchiooculofacial syndrome 10.2 DSP JUP
21 skin fragility-woolly hair syndrome 10.2 DSP JUP
22 gupta patton syndrome 10.2 DSP JUP
23 x-linked intellectual disability-epilepsy-progressive joint contractures-dysmorphism syndrome 10.2 DSC3 DSG1 PPL
24 myalgia-eosinophilia syndrome associated with tryptophan 10.2 DSG1 DSG3 DST
25 pallister-killian syndrome 10.2 DSP JUP
26 codas syndrome 10.2 DSP JUP
27 choanal atresia and lymphedema 10.1 DSP JUP
28 lymphoma 10.1
29 linear hamartoma syndrome 10.1 COL17A1 DST
30 carotid artery thrombosis 10.1 DSG1 DSP JUP
31 peptidic growth factors deficiency 10.1 COL17A1 DST
32 klippel-feil syndrome 2 10.1 DSP JUP
33 mucositis 10.1
34 ventricular tachycardia, catecholaminergic polymorphic, 4 10.1 DSP JUP
35 sarcoma 10.1
36 thymoma 10.1
37 sed, maroteaux type 10.0 ATP2C1 DSP JUP
38 dyskinesia of esophagus 10.0 COL17A1 DST
39 gilbert syndrome 10.0 COL17A1 DSP DST
40 bronchiolitis 10.0
41 fibular hemimelia, bilateral 10.0 DSG2 DSP JUP
42 esophagus carcinoma in situ 10.0 DSG1 DSG2 DSG4
43 fibular hemimelia, unilateral 10.0 DSG2 DSP JUP
44 congenital absence of upper arm and forearm with hand present, bilateral 10.0 DSG2 DSP JUP
45 bronchiolitis obliterans 10.0
46 myasthenia gravis 10.0
47 lupus erythematosus 10.0
48 psoriasis 10.0
49 lichen planus 10.0
50 nemaline myopathy 9 10.0 COL17A1 DST

Comorbidity relations with Pemphigus via Phenotypic Disease Network (PDN):


Acute Cystitis Bullous Pemphigoid
Decubitus Ulcer Heart Disease

Graphical network of the top 20 diseases related to Pemphigus:



Diseases related to Pemphigus

Symptoms & Phenotypes for Pemphigus

UMLS symptoms related to Pemphigus:


exanthema, pruritus

GenomeRNAi Phenotypes related to Pemphigus according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.58 CD79A DSG4
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.58 A2ML1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.58 A2ML1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.58 ATP2C1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-171 9.58 A2ML1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.58 CD79A DSG4 A2ML1 ATP2C1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.58 DSG4
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.58 ATP2C1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.58 ATP2C1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.58 DSG4
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.58 A2ML1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.58 A2ML1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.58 ATP2C1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.58 A2ML1

MGI Mouse Phenotypes related to Pemphigus:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.23 ATP2C1 DSC1 DSC3 DSG3 DSG4 DSP

Drugs & Therapeutics for Pemphigus

Drugs for Pemphigus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 94)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
2
rituximab Approved Phase 3,Phase 2,Phase 1 174722-31-7 10201696
3
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
4
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3 50-02-2 5743
5
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
6
Mycophenolic acid Approved Phase 3 24280-93-1 446541
7
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
8
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
9
Prednisone Approved, Vet_approved Phase 3,Phase 2,Early Phase 1 53-03-2 5865
10
Acetaminophen Approved Phase 3 103-90-2 1983
11
Cetirizine Approved Phase 3 83881-51-0 2678
12
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
13 Alkylating Agents Phase 3,Phase 2
14 Antineoplastic Agents, Alkylating Phase 3,Phase 2
15 Antirheumatic Agents Phase 3,Phase 2,Phase 1
16 Immunosuppressive Agents Phase 3,Phase 2,Early Phase 1
17 Gastrointestinal Agents Phase 2, Phase 3
18 Antibodies Phase 3,Phase 2
19 Immunoglobulins Phase 3,Phase 2
20 Anti-Inflammatory Agents Phase 3,Phase 2
21 glucocorticoids Phase 3,Phase 2
22 Hormone Antagonists Phase 3,Phase 2
23 Hormones Phase 3,Phase 2
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
25 triamcinolone acetonide Phase 3
26 Triamcinolone diacetate Phase 3
27 Triamcinolone hexacetonide Phase 3
28 Antiemetics Phase 2, Phase 3
29 Antineoplastic Agents, Hormonal Phase 2, Phase 3
30 Autonomic Agents Phase 2, Phase 3
31 BB 1101 Phase 2, Phase 3
32 Dexamethasone 21-phosphate Phase 2, Phase 3
33 Dexamethasone acetate Phase 2, Phase 3 1177-87-3
34 HIV Protease Inhibitors Phase 2, Phase 3
35 Peripheral Nervous System Agents Phase 2, Phase 3
36
protease inhibitors Phase 2, Phase 3
37 Anti-Bacterial Agents Phase 3,Phase 2,Early Phase 1
38 Antibiotics, Antitubercular Phase 3,Early Phase 1
39 gamma-Globulins Phase 3,Phase 2
40 Immunoglobulins, Intravenous Phase 3,Phase 2
41 Rho(D) Immune Globulin Phase 3,Phase 2
42 Antibodies, Monoclonal Phase 3,Phase 2
43 Analgesics Phase 3,Phase 2
44 Analgesics, Non-Narcotic Phase 3,Phase 2
45 Methylprednisolone acetate Phase 3,Phase 2
46 Methylprednisolone Hemisuccinate Phase 3,Phase 2
47 Prednisolone acetate Phase 3,Phase 2
48 Prednisolone hemisuccinate Phase 3,Phase 2
49 Prednisolone phosphate Phase 3,Phase 2
50 Neurotransmitter Agents Phase 3,Phase 1

Interventional clinical trials:

(show all 42)
id Name Status NCT ID Phase
1 Comparison of Two Therapeutic Strategies of Dermoval in Treatment of Bullous Pemphigus Completed NCT00213421 Phase 4
2 Comparative Study of Rituximab Versus Combination of Rituximab and Intravenous Cyclophosphamide in Severe Pemphigus Unknown status NCT01974518 Phase 3
3 Comparison Between Injections of Steroids and Autologous Platelet Rich Plasma in the Oral Erosions of Pemphigus Vulgaris Completed NCT02828163 Phase 3
4 Long-term Clinical and Biological Evaluation of Patients With Severe Forms of Pemphigus Treated by Rituximab Completed NCT01299857 Phase 3
5 Effect of Anti CD20 in Pemphigus Desease Completed NCT00213512 Phase 2, Phase 3
6 European Trial of Adjuvant Oral Glucocorticoid Pulse Therapy in Pemphigus Completed NCT00127764 Phase 2, Phase 3
7 A Study to Assess the Effect of CellCept (Mycophenolate Mofetil) and Reduced Corticosteroids in Patients With Active Pemphigus Vulgaris (PV) Completed NCT00683930 Phase 3
8 Phase III Clinical Trial of NPB-01 in Patients With Bullous Pemphigoid Unresponsive to Corticosteroids Completed NCT01408550 Phase 3
9 A Study to Evaluate the Efficacy and Safety of Rituximab Versus Mycophenolate Mofetil (MMF) in Participants With Pemphigus Vulgaris (PV) Recruiting NCT02383589 Phase 3
10 Comparison Between Rituximab Treatment and General Corticotherapy Treatment in Patients With Pemphigus Active, not recruiting NCT00784589 Phase 3
11 Efficacy and Safety of Ofatumumab in Treatment of Pemphigus Vulgaris Active, not recruiting NCT01920477 Phase 3
12 Pharmacokinetics Study of Mycophenolic Acid in Patients With an Autoimmune Bullous Dermatose, Pemphigus or Cicatricial Pemphigoid. Not yet recruiting NCT02993133 Phase 3
13 Long-Term Extension Study of Ofatumumab in Subjects With Pemphigus Vulgaris Terminated NCT02613910 Phase 3
14 Use of KC706 for the Treatment of Pemphigus Vulgaris Completed NCT00606749 Phase 2
15 Immunoadsorption, Dexamethasone Pulse Therapy and Rituximab for Pemphigus Completed NCT00656656 Phase 2
16 Azathioprine Versus Placebo in Pemphigus Vulgaris Treated With Prednisolone Completed NCT00626678 Phase 2
17 Study of Etanercept (Enbrel) in the Treatment of Pemphigus Vulgaris Completed NCT00135720 Phase 2
18 Use of Infliximab for the Treatment of Pemphigus Vulgaris Completed NCT00283712 Phase 2
19 Phase II Study of High-Dose Cyclophosphamide in Patients With Refractory Pemphigus Completed NCT00010413 Phase 2
20 Clinical Trial of NPB-01 in Patients With Bullous Pemphigoid Unresponsive to Corticosteroids. Completed NCT00809822 Phase 2
21 Clinical Trial Evaluating Rituximab in Ocular Cicatricial Pemphigoid Completed NCT00584935 Phase 1, Phase 2
22 Study of Efficacy and Safety of VAY736 in Patients With Pemphigus Vulgaris Recruiting NCT01930175 Phase 2
23 A Study of PRN1008 in Adult Patients With Pemphigus Vulgaris Recruiting NCT02704429 Phase 2
24 Randomized Trial of IVIg With or Without Cyclophosphamide in Pemphigus Terminated NCT00483119 Phase 2
25 Efficacy of Dapsone as a Steroid Sparing Agent in Pemphigus Vulgaris Terminated NCT00429533 Phase 2
26 Safety Study of PI-0824 to Treat Pemphigus Vulgaris Completed NCT00063752 Phase 1
27 Evaluation of the Improvement of Quality of Life of Patients Suffering From Hailey Hailey or Darier Disease After Injections of Botulism Toxin Into Large Folds. Active, not recruiting NCT02782702 Phase 1
28 A Safety Study of SYNT001 in Subjects With Pemphigus (Vulgaris or Foliaceus) Not yet recruiting NCT03075904 Phase 1
29 Hematopoietic Stem Cell Support in Patients With Autoimmune Bullous Skin Disorders Terminated NCT00278642 Phase 1
30 Treatment of Pemphigus Patients With Rituximab 1000mgX2 and Assessment of Immune Status Via Cylex Unknown status NCT01338103
31 Wound Dressings for Pemphigus and Pemphigoid Unknown status NCT02365675
32 National Registry for Ichthyosis and Related Disorders Unknown status NCT00074685
33 The RITAI Cohort: An Observational Study on Rituximab Off-label Use for Auto-immune Disorders Completed NCT00960713
34 Identification of Vulnerability Factors in the Course of Pemphigus Patients Recruiting NCT02237313
35 Autoimmune Blistering Diseases Study Recruiting NCT02753777
36 Role of Proteasomes in a Dermatological Autoimmune Disease: Bullous Pemphigoid Recruiting NCT01559155
37 Genetic Susceptibility and Influence of the Microbiomae in Bullous Pemphigoid Recruiting NCT02874079
38 Register of Autoimmune Bullous Dermatoses Recruiting NCT02899923
39 Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases Recruiting NCT01952275
40 Serum IL-21 Levels in Patients With Pemphigus Vulgaris Not yet recruiting NCT03177213
41 Serum FFA Desaturase Activity Index in Patients on High Dose Corticosteroids Not yet recruiting NCT02872584
42 Evaluating Sirolimus to Treat Autoimmune Blistering Dermatosis Pemphigus Terminated NCT01313923 Early Phase 1

Search NIH Clinical Center for Pemphigus

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: pemphigus

Genetic Tests for Pemphigus

Anatomical Context for Pemphigus

MalaCards organs/tissues related to Pemphigus:

39
Skin, Testes, T Cells, Eye, B Cells, Neutrophil, Lung

Publications for Pemphigus

Articles related to Pemphigus:

(show top 50) (show all 2261)
id Title Authors Year
1
Pregnancy outcome after rituximab treatment before conception in patients affected by severe pemphigus vulgaris/superficialis. ( 28079925 )
2017
2
Proteomic Analysis of Pemphigus Autoantibodies Indicates a Larger, More Diverse, and More Dynamic Repertoire than Determined by B Cell Genetics. ( 28052253 )
2017
3
The possible role of interleukin-35 and its therapeutic potential in pemphigus. ( 27855302 )
2017
4
Oral mucous membrane pemphigoid and pemphigus vulgaris- a retrospective two-center cohort study. ( 28084005 )
2017
5
Is photodynamic therapy a relevant therapeutic option in refractory benign familial pemphigus (Hailey-Hailey disease)? A series of eight patients. ( 28301978 )
2017
6
A reciprocal HLA-Disease Association in Rheumatoid Arthritis and Pemphigus Vulgaris. ( 27814654 )
2017
7
Correlation of antimuscarinic acetylcholine receptor antibody titers and antidesmoglein antibody titers with the severity of disease in patients with pemphigus. ( 28089115 )
2017
8
Salivary Samples for the Diagnosis of Pemphigus vulgaris Using the BIOCHIP Approach: a Pilot Study. ( 28064226 )
2017
9
Follicular pemphigus: an observation in patients treated with steroids. ( 28028859 )
2017
10
Efficacy of Dapsone in the Treatment of Pemphigus Vulgaris: A Single-Center Case Study. ( 27698327 )
2016
11
Interleukin 4 inhibition as a potential therapeutic in pemphigus. ( 26440137 )
2016
12
Case of paraneoplastic pemphigus with immunoglobulin (Ig)G and IgA antibodies to various antigens. ( 26969813 )
2016
13
Relapse of pemphigus vulgaris after topical application of ingenol mebutate. ( 27381839 )
2016
14
Unusual Histological Evidence of Dysplasia in a Case of Oral Pemphigus Vulgaris: A Potential Diagnostic Challenge. ( 27305938 )
2016
15
Pemphigus vulgaris and blood group antigens: no relationship. ( 27334804 )
2016
16
Successful monotherapy of pemphigus vegetans with minocycline and nicotinamide. ( 27600093 )
2016
17
Extremities of the N-terminus of envoplakin and C-terminus of its linker subdomain are major epitopes of paraneoplastic pemphigus. ( 27427435 )
2016
18
Castleman's Disease Presenting as Localized Abdominal Mass and Paraneoplastic Pemphigus. ( 27014502 )
2016
19
A possible interaction between periostin and CD163+ skin-resident macrophages in pemphigus vulgaris and bullous pemphigoid. ( 27501402 )
2016
20
Oral pemphigus vulgaris: A case report with direct immunofluorescence study. ( 27721634 )
2016
21
Determinants of VH1-46 Cross-Reactivity to Pemphigus Vulgaris Autoantigen Desmoglein 3 and Rotavirus Antigen VP6. ( 27402694 )
2016
22
Induction of T regulatory cells by the superagonistic anti-CD28 antibody D665 leads to decreased pathogenic IgG autoantibodies against desmoglein 3 in a HLA-transgenic mouse model of pemphigus vulgaris. ( 26661498 )
2016
23
Zeitlicher Verlauf der avaskulAoren Nekrose des HA1ftkopfes bei Patienten mit Pemphigus vulgaris. ( 27767277 )
2016
24
Pediatric case of oral mucous pemphigus complicated by protein-losing gastroenteropathy. ( 27130290 )
2016
25
Human leukocyte antigen class II (DRB1 and DQB1) alleles and haplotypes frequencies in patients with pemphigus vulgaris among the Serbian population. ( 27072514 )
2016
26
Radiotherapy-associated Pemphigus - a Rare Cause of Grade 4 Skin Toxicity. ( 27618424 )
2016
27
Concurrent Pemphigus Foliaceus and Graves' Disease. ( 27981628 )
2016
28
The pathogenesis of pemphigus: controversy versus complexity. ( 27571938 )
2016
29
Differential HLA class I and class II associations in pemphigus foliaceus and pemphigus vulgaris patients from a prevalent Southeastern Brazilian region. ( 27178774 )
2016
30
Familial benign pemphigus atypical localization. ( 27617466 )
2016
31
A Case Report on Paraneoplastic Pemphigus Associated Colonic Carcinoma. ( 27270550 )
2016
32
Pemphigus vulgaris successfully treated with doxycycline monotherapy. ( 27416094 )
2016
33
Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes. ( 27346727 )
2016
34
Juvenile IgA pemphigus: A case report and review of literature. ( 27126259 )
2016
35
Interleukin 21 as a new possible player in pemphigus: Is it a suitable target? ( 26945832 )
2016
36
Non-drug-induced pemphigus foliaceus in a patient with rheumatoid arthritis. ( 27023089 )
2016
37
A 3'UTR polymorphism marks differential KLRG1 mRNA levels through disruption of a miR-584-5p binding site and associates with pemphigus foliaceus susceptibility. ( 27424220 )
2016
38
Successful treatment with oral mizoribine in refractory ocular manifestation of mucosal pemphigus vulgaris: A unique response to different immunosuppressive drugs. ( 27418118 )
2016
39
Ocular Onset of Paraneoplastic Pemphigus Presenting as Hyperemic Conjunctivitis and Massive Bilateral Eyelid Ulceration: A Case Report and Literature Review. ( 27537424 )
2016
40
Pemphigus in North-Western Yemen: A therapeutic study of 75 cases. ( 27088959 )
2016
41
Identification of a Functional Risk Variant for Pemphigus Vulgaris in the ST18 Gene. ( 27148741 )
2016
42
Paronychia and onychomadesis due to pemphigus vulgaris. ( 27506502 )
2016
43
Systemic lupus erythematosus associated with myasthenia gravis, pemphigus foliaceus and chronic thyroiditis after thymectomy. ( 27270472 )
2016
44
Recurrent venous thrombosis in an adequately anticoagulated patient with pemphigus vulgaris. ( 26949375 )
2016
45
Peri-anal Paraneoplastic Pemphigus Heralding the Relapse of Follicular Lymphoma and Its Successful Management by Rituximab: A Short Correspondence. ( 27812271 )
2016
46
Assessment of the Effects of Rituximab Monotherapy on Different Subsets of Circulating T-Regulatory Cells and Clinical Disease Severity in Severe Pemphigus Vulgaris. ( 27576321 )
2016
47
Paraneoplastic pemphigus as a presentation of acute myeloid leukemia: Early diagnosis and remission. ( 27352260 )
2016
48
Half and half blisters in pemphigus vulgaris: A diagnostic quandary. ( 27559521 )
2016
49
Recurrent corneal melting in the paraneoplastic pemphigus associated with Castleman's disease. ( 27406120 )
2016
50
Endoplasmic Reticulum stress is associated with the pathogenesis of Pemphigus Vulgaris. ( 27060358 )
2016

Variations for Pemphigus

Expression for Pemphigus

Search GEO for disease gene expression data for Pemphigus.

Pathways for Pemphigus

GO Terms for Pemphigus

Cellular components related to Pemphigus according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.93 COL17A1 DSC1 DSC3 DSG1 DSG2 DSG3
2 cell-cell junction GO:0005911 9.73 COL17A1 DSC3 DSG1 DSG2 DSP JUP
3 intermediate filament GO:0005882 9.7 DSP DST JUP
4 ficolin-1-rich granule membrane GO:0101003 9.65 DSC1 DSG1 DSP
5 desmosome GO:0030057 9.65 DSC1 DSC3 DSG1 DSG2 DSG3 DSG4
6 lateral plasma membrane GO:0016328 9.63 DSG1 DSG2 JUP
7 intercalated disc GO:0014704 9.61 DSG2 DSP JUP
8 hemidesmosome GO:0030056 9.5 COL17A1 DST JUP
9 fascia adherens GO:0005916 9.49 DSP JUP
10 cornified envelope GO:0001533 9.32 DSC1 DSC3 DSG1 DSG2 DSG3 DSG4
11 membrane GO:0016020 10.32 ATP2C1 CD79A COL17A1 DSC1 DSC3 DSG1
12 plasma membrane GO:0005886 10.18 CD79A COL17A1 DSC1 DSC3 DSG1 DSG2
13 extracellular exosome GO:0070062 10.07 A2ML1 DSC1 DSG1 DSG2 DSG3 DSP

Biological processes related to Pemphigus according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.86 DSC1 DSC3 DSG1 DSG2 DSG3 DSG4
2 neutrophil degranulation GO:0043312 9.85 DSC1 DSG1 DSP JUP
3 single organismal cell-cell adhesion GO:0016337 9.73 DSG1 DSG4 DSP JUP
4 epidermis development GO:0008544 9.71 ATP2C1 COL17A1 DSP EVPL
5 keratinocyte differentiation GO:0030216 9.67 DSG4 DSP EVPL
6 keratinization GO:0031424 9.65 DSC1 DSC3 DSG1 DSG2 DSG3 DSG4
7 regulation of heart rate by cardiac conduction GO:0086091 9.63 DSG2 DSP JUP
8 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.63 DSC1 DSC3 DSG1 DSG2 DSG3 DSG4
9 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339 9.54 ATP2C1 DSG1
10 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.54 DSG2 DSP JUP
11 maternal process involved in female pregnancy GO:0060135 9.52 DSG1 DSG2
12 intermediate filament cytoskeleton organization GO:0045104 9.51 DSP DST
13 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 9.5 DSG2 DSP JUP
14 desmosome organization GO:0002934 9.48 DSG2 DSP
15 cornification GO:0070268 9.32 DSC1 DSC3 DSG1 DSG2 DSG3 DSG4

Molecular functions related to Pemphigus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.5 DSC1 DSC3 DSG1 DSG2 DSG3 DSG4
2 cell adhesion molecule binding GO:0050839 9.33 DSG2 DSP JUP
3 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 8.8 DSG2 DSP JUP

Sources for Pemphigus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....