Aliases & Classifications for Pemphigus

MalaCards integrated aliases for Pemphigus:

Name: Pemphigus 12 50 52 41 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9182
ICD10 33 L10 L10.9
ICD9CM 35 694.4
MeSH 42 D010392
NCIt 47 C34909
UMLS 69 C0030807

Summaries for Pemphigus

NIH Rare Diseases : 50 pemphigus is a group of rare autoimmune diseases that cause blistering of the skin and mucous membranes (mouth, nose, throat, eyes, and genitals). this condition can occur at any age, but often strikes people in middle or older age. studies have shown that some populations may be at greater risk for certain types of pemphigus. for instance, people of jewish descent and those from india, southeast europe, and the middle east are at greater risk for pemphigus vulargis, while pemphigus foliaceus is more common in north america, turkey, and south america. pemphigus is a chronic disease which is best controlled by early diagnosis and treatment. treatment includes steroids to reduce inflammation, drugs that suppress the immune system response and antibiotics to treat associated infections. there are four main types of pemphigus: pemphigus vulgaris pemphigus foliaceus iga pemphigus paraneoplastic pemphigus last updated: 8/12/2016

MalaCards based summary : Pemphigus is related to lymphoma and usher syndrome, and has symptoms including exanthema and pruritus. An important gene associated with Pemphigus is DSG3 (Desmoglein 3), and among its related pathways/superpathways are Developmental Biology and Keratinization. The drugs Cyclophosphamide and rituximab have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and integument

MedlinePlus : 41 pemphigus is an autoimmune disorder. if you have it, your immune system attacks healthy cells in your skin and mouth, causing blisters and sores. no one knows the cause. pemphigus does not spread from person to person. it does not appear to be inherited. but some people's genes put them more at risk for pemphigus. pemphigoid is also an autoimmune skin disease. it leads to deep blisters that do not break easily. pemphigoid is most common in older adults and may be fatal for older, sick patients. doctors diagnose pemphigus with a physical exam, a biopsy, and blood tests. the treatment of pemphigus and pemphigoid is the same: one or more medicines to control symptoms. these may include steroids, which reduce inflammation drugs that suppress the immune system response antibiotics to treat associated infections nih: national institute of arthritis and musculoskeletal and skin diseases

Wikipedia : 72 9764... more...

Related Diseases for Pemphigus

Diseases related to Pemphigus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 295)
id Related Disease Score Top Affiliating Genes
1 lymphoma 29.3 CD79A COL17A1 DST
2 usher syndrome 29.3 DSG2 DSP JUP
3 dermatitis herpetiformis 26.0 ATP2C1 CD79A COL17A1 DSC3 DSG1 DSG3
4 pemphigus vulgaris 12.5
5 pemphigus foliaceus 12.3
6 pemphigus erythematosus 12.3
7 pemphigus vegetans 12.3
8 paraneoplastic pemphigus 12.2
9 pemphigus vulgaris, familial 12.2
10 pemphigus and fogo selvagem 12.1
11 herpetiform pemphigus 12.0
12 hailey-hailey disease 12.0
13 cicatricial pemphigoid 11.5
14 bullous pemphigoid 11.3
15 x-linked intellectual disability-hypogammaglobulinemia-progressive neurological deterioration syndrome 10.8 DSG3 DSP
16 epidermolysis bullosa, lethal acantholytic 10.8
17 arrhythmogenic right ventricular dysplasia 10 10.7 DSG1 DSP
18 ritter's disease 10.7
19 isolated scaphocephaly 10.7 DSG1 DSG3
20 dilated cardiomyopathy with woolly hair, keratoderma, and tooth agenesis 10.6 DSP JUP
21 growth retardation hydrocephaly lung hypoplasia 10.5 DSP JUP
22 arrhythmogenic right ventricular dysplasia 8 10.5 DSP JUP
23 ischio-vertebral syndrome 10.5 DSC3 DSG1 PPL
24 idiopathic neonatal atrial flutter 10.5 DSG1 DSP
25 hypercholesterolemia, familial 10.5 DSP JUP
26 ectodermal dysplasia/skin fragility syndrome 10.4 DSP JUP
27 vesicoureteral reflux 7 10.4 DSP JUP
28 skin amelanotic melanoma 10.4 DSG1 DSG3
29 skin fragility-woolly hair syndrome 10.4 DSP JUP
30 intellectual disability-short stature-hypertelorism syndrome 10.4 DSG1 DSG3 DST
31 arrhythmogenic right ventricular dysplasia 12 10.4 DSP JUP
32 carotid artery disease 10.3 DSG1 DSP JUP
33 linear iga disease 10.3
34 acrokeratosis verruciformis 10.2 ATP2C1 DSP JUP
35 mucositis 10.1
36 loeys-dietz syndrome 5 10.1 DSP JUP
37 lethal midline granuloma 10.1 DSG1 DSG2 DSG4
38 thymoma 10.1
39 sarcoma 10.0
40 bronchiolitis 10.0
41 bronchiolitis obliterans 10.0
42 retinitis pigmentosa 4, autosomal dominant or recessive 10.0 ATP2C1 DSG1 DSP JUP
43 lichen planus 10.0
44 myasthenia gravis 10.0
45 lupus erythematosus 10.0
46 psoriasis 10.0
47 ulnar hemimelia, unilateral 10.0 DSG2 DSP JUP
48 ulnar hemimelia, bilateral 10.0 DSG2 DSP JUP
49 tibial hemimelia, bilateral 10.0 DSG2 DSP JUP
50 leukemia 9.9

Comorbidity relations with Pemphigus via Phenotypic Disease Network (PDN):


Acute Cystitis Bullous Pemphigoid
Decubitus Ulcer Heart Disease

Graphical network of the top 20 diseases related to Pemphigus:



Diseases related to Pemphigus

Symptoms & Phenotypes for Pemphigus

UMLS symptoms related to Pemphigus:


exanthema, pruritus

GenomeRNAi Phenotypes related to Pemphigus according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.58 CD79A DSG4
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.58 A2ML1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.58 A2ML1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.58 ATP2C1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-171 9.58 A2ML1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.58 A2ML1 ATP2C1 CD79A DSG4
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.58 DSG4
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.58 ATP2C1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.58 ATP2C1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.58 DSG4
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.58 A2ML1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.58 A2ML1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.58 ATP2C1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.58 A2ML1

MGI Mouse Phenotypes related to Pemphigus:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.23 ATP2C1 DSC1 DSC3 DSG3 DSG4 DSP

Drugs & Therapeutics for Pemphigus

Drugs for Pemphigus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 92)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
2
rituximab Approved Phase 3,Phase 2,Phase 1 174722-31-7 10201696
3
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
4
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3 50-02-2 5743
5
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
6
Mycophenolic acid Approved Phase 3 24280-93-1 446541
7
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
8
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
9
Prednisone Approved, Vet_approved Phase 3,Phase 2,Early Phase 1 53-03-2 5865
10
Acetaminophen Approved Phase 3 103-90-2 1983
11
Cetirizine Approved Phase 3 83881-51-0 2678
12
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
13 Alkylating Agents Phase 3,Phase 2
14 Antirheumatic Agents Phase 3,Phase 2,Phase 1
15 Immunosuppressive Agents Phase 3,Phase 2,Early Phase 1
16 Antibodies Phase 3,Phase 2
17 Immunoglobulins Phase 3,Phase 2
18 Gastrointestinal Agents Phase 2, Phase 3
19 Antibodies, Monoclonal Phase 3,Phase 2
20 Anti-Inflammatory Agents Phase 3,Phase 2
21 glucocorticoids Phase 3,Phase 2
22 Hormone Antagonists Phase 3,Phase 2
23 Hormones Phase 3,Phase 2
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
25 triamcinolone acetonide Phase 3
26 Triamcinolone diacetate Phase 3
27 Triamcinolone hexacetonide Phase 3
28 Antiemetics Phase 2, Phase 3
29 Antineoplastic Agents, Hormonal Phase 2, Phase 3
30 Autonomic Agents Phase 2, Phase 3
31 BB 1101 Phase 2, Phase 3
32 Dexamethasone acetate Phase 2, Phase 3 1177-87-3
33 HIV Protease Inhibitors Phase 2, Phase 3
34 Peripheral Nervous System Agents Phase 2, Phase 3
35
protease inhibitors Phase 2, Phase 3
36 Anti-Bacterial Agents Phase 3,Phase 2,Early Phase 1
37 Antibiotics, Antitubercular Phase 3,Early Phase 1
38 gamma-Globulins Phase 3,Phase 2
39 Immunoglobulins, Intravenous Phase 3,Phase 2
40 Rho(D) Immune Globulin Phase 3,Phase 2
41 Analgesics Phase 3,Phase 2
42 Analgesics, Non-Narcotic Phase 3,Phase 2
43 Methylprednisolone acetate Phase 3,Phase 2
44 Methylprednisolone Hemisuccinate Phase 3,Phase 2
45 Prednisolone acetate Phase 3,Phase 2
46 Prednisolone hemisuccinate Phase 3,Phase 2
47 Prednisolone phosphate Phase 3,Phase 2
48 Neurotransmitter Agents Phase 3,Phase 1
49 Anti-Allergic Agents Phase 3
50 Antipyretics Phase 3

Interventional clinical trials:

(show all 43)

id Name Status NCT ID Phase Drugs
1 Comparison of Two Therapeutic Strategies of Dermoval in Treatment of Bullous Pemphigus Completed NCT00213421 Phase 4 Dermoval
2 Comparative Study of Rituximab Versus Combination of Rituximab and Intravenous Cyclophosphamide in Severe Pemphigus Unknown status NCT01974518 Phase 3 Rituximab and Cyclophosphamide IV
3 Comparison Between Rituximab Treatment and General Corticotherapy Treatment in Patients With Pemphigus Completed NCT00784589 Phase 3 General Corticotherapy;Rituximab
4 Comparison Between Injections of Steroids and Autologous Platelet Rich Plasma in the Oral Erosions of Pemphigus Vulgaris Completed NCT02828163 Phase 3 Triamcinolone Acetonide
5 Long-term Clinical and Biological Evaluation of Patients With Severe Forms of Pemphigus Treated by Rituximab Completed NCT01299857 Phase 3 Rituximab
6 Effect of Anti CD20 in Pemphigus Desease Completed NCT00213512 Phase 2, Phase 3 Mabthera
7 European Trial of Adjuvant Oral Glucocorticoid Pulse Therapy in Pemphigus Completed NCT00127764 Phase 2, Phase 3 dexamethasone (50mg 1dd6, 3 consecutive days/month)
8 A Study to Assess the Effect of CellCept (Mycophenolate Mofetil) and Reduced Corticosteroids in Patients With Active Pemphigus Vulgaris (PV) Completed NCT00683930 Phase 3 Mycophenolate Mofetil 2 g/Day;Mycophenolate Mofetil (MMF) 3 g/Day;Placebo
9 Phase III Clinical Trial of NPB-01 in Patients With Bullous Pemphigoid Unresponsive to Corticosteroids Completed NCT01408550 Phase 3 NPB-01;Placebo
10 A Study to Evaluate the Efficacy and Safety of Rituximab Versus Mycophenolate Mofetil (MMF) in Participants With Pemphigus Vulgaris (PV) Recruiting NCT02383589 Phase 3 Mycophenolate Mofetil Placebo;Mycophenolate Mofetil;Rituximab;Rituximab Placebo
11 Pharmacokinetics Study of Mycophenolic Acid in Patients With an Autoimmune Bullous Dermatose, Pemphigus or Cicatricial Pemphigoid. Recruiting NCT02993133 Phase 3 Cellcept® in autoimmune bullous dermatoses
12 Efficacy and Safety of Ofatumumab in Treatment of Pemphigus Vulgaris Active, not recruiting NCT01920477 Phase 3
13 Long-Term Extension Study of Ofatumumab in Subjects With Pemphigus Vulgaris Terminated NCT02613910 Phase 3 Ofatumumab;Acetaminophen/paracetamol;Antihistamine (cetirizine or equivalent);Prednisone/Prednisolone
14 Use of KC706 for the Treatment of Pemphigus Vulgaris Completed NCT00606749 Phase 2 KC706
15 Immunoadsorption, Dexamethasone Pulse Therapy and Rituximab for Pemphigus Completed NCT00656656 Phase 2 Combination of Protein A Immunoadsorption, Rituximab, Dexamethasone plus Azathioprine
16 Azathioprine Versus Placebo in Pemphigus Vulgaris Treated With Prednisolone Completed NCT00626678 Phase 2 Azathioprine;Prednisone;Placebo
17 Study of Etanercept (Enbrel) in the Treatment of Pemphigus Vulgaris Completed NCT00135720 Phase 2 Enbrel (Etanercept)
18 Use of Infliximab for the Treatment of Pemphigus Vulgaris Completed NCT00283712 Phase 2 Infliximab;Prednisone
19 Phase II Study of High-Dose Cyclophosphamide in Patients With Refractory Pemphigus Completed NCT00010413 Phase 2 cyclophosphamide;filgrastim
20 Clinical Trial of NPB-01 in Patients With Bullous Pemphigoid Unresponsive to Corticosteroids. Completed NCT00809822 Phase 2 NPB-01;Placebo
21 Clinical Trial Evaluating Rituximab in Ocular Cicatricial Pemphigoid Completed NCT00584935 Phase 1, Phase 2 Rituximab
22 A Study of PRN1008 in Adult Patients With Pemphigus Vulgaris Recruiting NCT02704429 Phase 2 PRN1008
23 Study of Efficacy and Safety of VAY736 in Patients With Pemphigus Vulgaris Active, not recruiting NCT01930175 Phase 2 VAY736;Placebo to VAY736;VAY736
24 Randomized Trial of IVIg With or Without Cyclophosphamide in Pemphigus Terminated NCT00483119 Phase 2 intravenous immunoglobulin;cyclophosphamide
25 Efficacy of Dapsone as a Steroid Sparing Agent in Pemphigus Vulgaris Terminated NCT00429533 Phase 2 Dapsone
26 Safety Study of PI-0824 to Treat Pemphigus Vulgaris Completed NCT00063752 Phase 1 PI-0824
27 A Safety Study of SYNT001 in Subjects With Pemphigus (Vulgaris or Foliaceus) Recruiting NCT03075904 Phase 1 SYNT001
28 Polyclonal Regulatory T Cells (PolyTregs) for Pemphigus Recruiting NCT03239470 Phase 1
29 Evaluation of the Improvement of Quality of Life of Patients Suffering From Hailey Hailey or Darier Disease After Injections of Botulism Toxin Into Large Folds. Active, not recruiting NCT02782702 Phase 1 Botulism Toxin Treatment
30 Hematopoietic Stem Cell Support in Patients With Autoimmune Bullous Skin Disorders Terminated NCT00278642 Phase 1
31 Treatment of Pemphigus Patients With Rituximab 1000mgX2 and Assessment of Immune Status Via Cylex Unknown status NCT01338103 Rituximab
32 Wound Dressings for Pemphigus and Pemphigoid Unknown status NCT02365675
33 National Registry for Ichthyosis and Related Disorders Unknown status NCT00074685
34 The RITAI Cohort: An Observational Study on Rituximab Off-label Use for Auto-immune Disorders Completed NCT00960713 Rituximab (MABTHERA® or RITUXAN®).
35 Identification of Vulnerability Factors in the Course of Pemphigus Patients Recruiting NCT02237313
36 Autoimmune Blistering Diseases Study Recruiting NCT02753777
37 Role of Proteasomes in a Dermatological Autoimmune Disease: Bullous Pemphigoid Recruiting NCT01559155
38 Genetic Susceptibility and Influence of the Microbiomae in Bullous Pemphigoid Recruiting NCT02874079
39 Register of Autoimmune Bullous Dermatoses Recruiting NCT02899923
40 Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases Recruiting NCT01952275
41 Serum IL-21 Levels in Patients With Pemphigus Vulgaris Not yet recruiting NCT03177213
42 Serum FFA Desaturase Activity Index in Patients on High Dose Corticosteroids Not yet recruiting NCT02872584 Prednisone
43 Evaluating Sirolimus to Treat Autoimmune Blistering Dermatosis Pemphigus Terminated NCT01313923 Early Phase 1 Sirolimus (formerly known as Rapamycin)

Search NIH Clinical Center for Pemphigus

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: pemphigus

Genetic Tests for Pemphigus

Anatomical Context for Pemphigus

MalaCards organs/tissues related to Pemphigus:

39
Skin, T Cells, Testes, Eye, B Cells, Neutrophil, Lung

Publications for Pemphigus

Articles related to Pemphigus:

(show top 50) (show all 2335)
id Title Authors Year
1
Clinical Analysis of Unicentric Castleman's Disease with Paraneoplastic Pemphigus and Bronchiolitis Obliterans. ( 28877826 )
2017
2
NUDT15 polymorphism and severe azathioprine-induced myelosuppression in a Chinese man with pemphigus vulgaris. ( 28733976 )
2017
3
IgA multiple myeloma in a patient with an IgG pemphigus foliaceus-like exanthem. ( 28856664 )
2017
4
Salivary Samples for the Diagnosis of Pemphigus vulgaris Using the BIOCHIP Approach: a Pilot Study. ( 28064226 )
2017
5
Myiasis in a neglected case of generalized erythrodermic pemphigus foliaceus. ( 28366917 )
2017
6
Appearance of anti-desmocollin 1 autoantibodies leading to a vegetative lesion in a pemphigus vulgaris patient. ( 28734006 )
2017
7
Proteomic Analysis of Pemphigus Autoantibodies Indicates a Larger, More Diverse, and More Dynamic Repertoire than Determined by B Cell Genetics. ( 28052253 )
2017
8
Successful treatment with bendamustine and rituximab for paraneoplastic pemphigus. ( 28447163 )
2017
9
Exacerbated pemphigus vulgaris superinfected with herpes virus II, chemoattracting a florid inflammatory response. ( 28704987 )
2017
10
Follicular pemphigus: an observation in patients treated with steroids. ( 28028859 )
2017
11
Grover's disease in a patient with pemphigus vulgaris. ( 28766705 )
2017
12
Miniaturization of sebaceous glands: A novel histopathological finding in pemphigus vulgaris and pemphigus foliaceus of the scalp. ( 28632917 )
2017
13
The possible role of interleukin-35 and its therapeutic potential in pemphigus. ( 27855302 )
2017
14
Pemphigus Vulgaris and Pemphigus Foliaceus: Differences in Epidemiology and Mortality. ( 28536732 )
2017
15
Geographical foci and epidemiological changes of pemphigus vulgaris in four decades in Southeastern Brazil. ( 28737218 )
2017
16
Cytokine and Chemokines Alterations in the Endemic Form of Pemphigus Foliaceus (Fogo Selvagem). ( 28855908 )
2017
17
Paraneoplastic Pemphigus. A Life-Threatening Autoimmune Blistering Disease. ( 28801011 )
2017
18
Intraepidermal neutrophilic dermatosis type of IgA pemphigus with circulating linear IgA disease antibodies associated with ulcerative colitis. ( 28653439 )
2017
19
Childhood Occurrence of Pemphigus. ( 28890623 )
2017
20
Is there an association between pemphigus and hepatitis viruses? A population-based large-scale study. ( 28905194 )
2017
21
Robotic trans-subxiphoid extended thymectomy in a patient with thymoma-associated pemphigus. ( 28740698 )
2017
22
Rituximab in the management of juvenile pemphigus foliaceus. ( 28633733 )
2017
23
Biologic therapy-induced pemphigus. ( 28954128 )
2017
24
Achievement of the longest survival of paraneoplastic pemphigus with bronchiolitis obliterans associated with follicular lymphoma using R-CHOP chemotherapy. ( 28791608 )
2017
25
Localized pemphigus foliaceus. ( 28207020 )
2017
26
Delayed and localized pemphigus vulgaris after breast cancer radiotherapy. ( 28892216 )
2017
27
Oral mucous membrane pemphigoid and pemphigus vulgaris- a retrospective two-center cohort study. ( 28084005 )
2017
28
Jaw Pain in a Pemphigus Patient on Prednisolone, Mycophenolate Mofetil and Denosumab. ( 28920136 )
2017
29
CD59 polymorphisms are associated with gene expression and different sexual susceptibility to pemphigus foliaceus. ( 28534443 )
2017
30
Mean Platelet Volume in Pemphigus Vulgaris. ( 28681645 )
2017
31
Paraneoplastic pemphigus seen in four patients with haematological malignancies formerly treated with rituximab. ( 28758262 )
2017
32
Pemphigus vulgaris and pemphigus foliaceus determined by CD86 and CTLA4 polymorphisms. ( 28274366 )
2017
33
Rituximab administration in a patient with pemphigus vulgaris following reactivation of occult hepatitis B virus infection. ( 28633752 )
2017
34
Pemphigus vegetans arising in umbilicus: Successful clearance with intralesional steroid. ( 28879869 )
2017
35
Using immune checkpoint inhibitors without exacerbation in a melanoma patient with pemphigus foliaceus. ( 28762466 )
2017
36
Association between schizophrenia and an autoimmune bullous skin disease-pemphigus: a population-based large-scale study. ( 28942756 )
2017
37
Herpes simplex virus 1 and cytomegalovirus are associated with pemphigus vulgaris but not with pemphigus foliaceus disease. ( 28370424 )
2017
38
Putative contact ketoconazole shampoo-triggered pemphigus foliaceus in a dog. ( 28878412 )
2017
39
Successful treatment of pemphigus foliaceus in a Berrichon du Cher ram with methylprednisolone acetate. ( 28378419 )
2017
40
Paraneoplastic pemphigus associated with Castleman disease: progression from mucous to mucocutaneous lesions with epitope-spreading phenomena. ( 28213962 )
2017
41
Is photodynamic therapy a relevant therapeutic option in refractory benign familial pemphigus (Hailey-Hailey disease)? A series of eight patients. ( 28301978 )
2017
42
Oral pemphigus vulgaris: Liquid-based cytological findings and pitfalls. ( 28799730 )
2017
43
The Use of Intralesional Steroids in a Case of Localized Pemphigus Foliaceus. ( 28868007 )
2017
44
A reciprocal HLA-Disease Association in Rheumatoid Arthritis and Pemphigus Vulgaris. ( 27814654 )
2017
45
Successful use of Bruton's kinase inhibitor, ibrutinib, to control paraneoplastic pemphigus in a patient with paraneoplastic autoimmune multiorgan syndrome and chronic lymphocytic leukaemia. ( 28295171 )
2017
46
Low-Dose Naltrexone Treatment of Familial Benign Pemphigus (Hailey-Hailey Disease). ( 28768314 )
2017
47
Viral reactivation imitates relapse of pemphigus vulgaris in an immunosuppressed patient. ( 28921892 )
2017
48
Paraneoplastic pemphigus in two pairs of brothers. ( 28622444 )
2017
49
Selective Plasma Exchange for the Removal of Pemphigus Autoantibodies, Fibrinogen, and Factor XIII in Pemphigus Vulgaris. ( 28661086 )
2017
50
Dermatoscopy in Diagnosis of Cutaneous Myiasis Arising in Pemphigus Vulgaris Lesions. ( 28794566 )
2017

Variations for Pemphigus

Expression for Pemphigus

Search GEO for disease gene expression data for Pemphigus.

Pathways for Pemphigus

GO Terms for Pemphigus

Cellular components related to Pemphigus according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.97 COL17A1 DSC1 DSC3 DSG1 DSG2 DSG3
2 cell-cell junction GO:0005911 9.73 COL17A1 DSC3 DSG1 DSG2 DSP JUP
3 ficolin-1-rich granule membrane GO:0101003 9.65 DSC1 DSG1 DSP
4 cornified envelope GO:0001533 9.65 DSC1 DSC3 DSG1 DSG2 DSG3 DSG4
5 lateral plasma membrane GO:0016328 9.63 DSG1 DSG2 JUP
6 intercalated disc GO:0014704 9.61 DSG2 DSP JUP
7 fascia adherens GO:0005916 9.51 DSP JUP
8 hemidesmosome GO:0030056 9.5 COL17A1 DST JUP
9 desmosome GO:0030057 9.32 DSC1 DSC3 DSG1 DSG2 DSG3 DSG4
10 membrane GO:0016020 10.34 ATP2C1 CD79A COL17A1 DSC1 DSC3 DSG1
11 integral component of membrane GO:0016021 10.26 ATP2C1 CD79A COL17A1 DSC1 DSC3 DSG1
12 plasma membrane GO:0005886 10.22 CD79A COL17A1 DSC1 DSC3 DSG1 DSG2
13 extracellular exosome GO:0070062 10.11 A2ML1 DSC1 DSG1 DSG2 DSG3 DSP

Biological processes related to Pemphigus according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.89 DSC1 DSG1 DSP JUP PLAUR
2 cell adhesion GO:0007155 9.86 DSC1 DSC3 DSG1 DSG2 DSG3 DSG4
3 epidermis development GO:0008544 9.73 ATP2C1 COL17A1 DSP EVPL
4 single organismal cell-cell adhesion GO:0016337 9.71 DSG1 DSG4 DSP JUP
5 keratinocyte differentiation GO:0030216 9.69 DSG4 DSP EVPL
6 cornification GO:0070268 9.65 DSC1 DSC3 DSG1 DSG2 DSG3 DSG4
7 regulation of heart rate by cardiac conduction GO:0086091 9.63 DSG2 DSP JUP
8 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.63 DSC1 DSC3 DSG1 DSG2 DSG3 DSG4
9 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339 9.55 ATP2C1 DSG1
10 maternal process involved in female pregnancy GO:0060135 9.54 DSG1 DSG2
11 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.54 DSG2 DSP JUP
12 intermediate filament cytoskeleton organization GO:0045104 9.52 DSP DST
13 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 9.5 DSG2 DSP JUP
14 desmosome organization GO:0002934 9.48 DSG2 DSP
15 keratinization GO:0031424 9.32 DSC1 DSC3 DSG1 DSG2 DSG3 DSG4

Molecular functions related to Pemphigus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.5 DSC1 DSC3 DSG1 DSG2 DSG3 DSG4
2 cell adhesion molecule binding GO:0050839 9.33 DSG2 DSP JUP
3 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 8.8 DSG2 DSP JUP

Sources for Pemphigus

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34 ICD10 via Orphanet
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55 OMIM via Orphanet
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