MCID: PMP001
MIFTS: 55

Pemphigus

Categories: Rare diseases, Skin diseases, Genetic diseases

Aliases & Classifications for Pemphigus

MalaCards integrated aliases for Pemphigus:

Name: Pemphigus 12 72 49 36 51 40 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9182
ICD10 32 L10 L10.9
ICD9CM 34 694.4
MeSH 41 D010392
NCIt 46 C34909
KEGG 36 H01648
UMLS 69 C0030807

Summaries for Pemphigus

NIH Rare Diseases : 49 Pemphigus is a group of rare autoimmune diseases that cause blistering of the skin and mucous membranes (mouth, nose, throat, eyes, and genitals). This condition can occur at any age, but often strikes people in middle or older age. Studies have shown that some populations may be at greater risk for certain types of pemphigus. For instance, people of Jewish descent and those from India, Southeast Europe, and the Middle East are at greater risk for pemphigus vulargis, while pemphigus foliaceus is more common in North America, Turkey, and South America. Pemphigus is a chronic disease which is best controlled by early diagnosis and treatment. Treatment includes steroids to reduce inflammation, drugs that suppress the immune system response and antibiotics to treat associated infections. There are four main types of pemphigus: Pemphigus vulgaris Pemphigus foliaceus IgA pemphigus Paraneoplastic pemphigus Last updated: 8/12/2016

MalaCards based summary : Pemphigus is related to pemphigus erythematosus and pemphigus vegetans, and has symptoms including pruritus and exanthema. An important gene associated with Pemphigus is DSG3 (Desmoglein 3), and among its related pathways/superpathways are Developmental Biology and Keratinization. The drugs Cyclophosphamide and rituximab have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

MedlinePlus : 40 Pemphigus is an autoimmune disorder. If you have it, your immune system attacks healthy cells in your skin and mouth, causing blisters and sores. No one knows the cause. Pemphigus does not spread from person to person. It does not appear to be inherited. But some people's genes put them more at risk for pemphigus. Pemphigoid is also an autoimmune skin disease. It leads to deep blisters that do not break easily. Pemphigoid is most common in older adults and may be fatal for older, sick patients. Doctors diagnose pemphigus with a physical exam, a biopsy, and blood tests. The treatment of pemphigus and pemphigoid is the same: one or more medicines to control symptoms. These may include Steroids, which reduce inflammation Drugs that suppress the immune system response Antibiotics to treat associated infections NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Wikipedia : 72 Pemphigus (/ˈpɛmfɪɡəs/ or /pɛmˈfaɪɡəs/) is a rare group of blistering autoimmune diseases that affect... more...

Related Diseases for Pemphigus

Diseases in the Pemphigus family:

Benign Chronic Pemphigus

Diseases related to Pemphigus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 326)
# Related Disease Score Top Affiliating Genes
1 pemphigus erythematosus 34.4 DSG3 DSP
2 pemphigus vegetans 34.1 DSC3 DSG1 PPL
3 benign chronic pemphigus 33.9 ATP2C1 DSP JUP
4 herpetiform pemphigus 33.5 DSG1 DSG3 DST
5 pemphigus foliaceus 32.9 DSG1 DSG2 DSG3 DST EVPL PPL
6 ritter's disease 32.4 DSG1 DSG2 DSG4
7 epidermolysis bullosa, lethal acantholytic 31.9 DSP JUP
8 cicatricial pemphigoid 31.8 CD79A COL17A1 DST
9 pemphigus vulgaris 31.7 DSC3 DSG1 DSG2 DSG3 DSG4 DSP
10 follicular dendritic cell sarcoma 30.5 DSP EVPL PPL
11 bullous impetigo 30.5 DSG1 DSG3
12 paraneoplastic pemphigus 30.4 A2ML1 COL17A1 DSC1 DSC3 DSG1 DSG2
13 bullous pemphigoid 30.2 CD79A COL17A1 DSG1 DSG3 DSP DST
14 linear iga disease 30.0 CD79A COL17A1 DST
15 lichen planus 29.7 COL17A1 DSG3 DST
16 grover's disease 29.7 DSP JUP
17 lichen planus pemphigoides 29.5 COL17A1 DST
18 hypotrichosis 29.4 DSC3 DSG1 DSG4
19 darier-white disease 29.4 ATP2C1 DSP JUP
20 pemphigoid gestationis 29.2 COL17A1 DST
21 erythema multiforme 29.1 CD79A DSP
22 herpes gestationis 28.7 CD79A COL17A1 DST
23 epidermolysis bullosa 28.7 COL17A1 DSP DST
24 subcorneal pustular dermatosis 27.6 CD79A COL17A1 DSC1 DSC3 DSG1 DSG3
25 skin disease 27.6 ATP2C1 CD79A COL17A1 DSC1 DSG1 DSG3
26 bullous skin disease 26.5 ATP2C1 CD79A COL17A1 DSC3 DSG1 DSG3
27 pemphigus vulgaris, familial 12.5
28 pemphigus and fogo selvagem 12.2
29 erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper-ige 10.5 DSG1 DSP
30 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.4
31 striate palmoplantar keratoderma 10.4 DSG1 DSP
32 cardiomyopathy, dilated, with woolly hair and keratoderma 10.3 DSP JUP
33 palmoplantar keratoderma and woolly hair 10.3 DSP JUP
34 ectodermal dysplasia/skin fragility syndrome 10.3 DSP JUP
35 naxos disease 10.3 DSP JUP
36 lymphoma 10.2
37 arrhythmogenic right ventricular dysplasia, familial, 9 10.2 DSP JUP
38 palmoplantar keratosis 10.2 DSG1 DSP JUP
39 arrhythmogenic right ventricular dysplasia, familial, 8 10.2 DSP JUP
40 mucositis 10.2
41 thymoma, familial 10.2
42 thymoma 10.2
43 sarcoma 10.1
44 bronchiolitis 10.1
45 bronchiolitis obliterans 10.1
46 pustulosis of palm and sole 10.1
47 psoriasis 10.1
48 blood group, i system 10.1
49 lupus erythematosus 10.1
50 arrhythmogenic right ventricular dysplasia, familial, 1 10.1 DSP JUP

Comorbidity relations with Pemphigus via Phenotypic Disease Network (PDN):


Acute Cystitis Bullous Pemphigoid
Decubitus Ulcer Heart Disease

Graphical network of the top 20 diseases related to Pemphigus:



Diseases related to Pemphigus

Symptoms & Phenotypes for Pemphigus

UMLS symptoms related to Pemphigus:


pruritus, exanthema

GenomeRNAi Phenotypes related to Pemphigus according to GeneCards Suite gene sharing:

25 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.58 DSG4 CD79A
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.58 A2ML1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.58 A2ML1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.58 ATP2C1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-171 9.58 A2ML1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.58 A2ML1 ATP2C1 CD79A DSG4
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.58 DSG4
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.58 ATP2C1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.58 ATP2C1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.58 DSG4
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.58 A2ML1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.58 A2ML1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.58 ATP2C1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.58 A2ML1

MGI Mouse Phenotypes related to Pemphigus:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.28 ATP2C1 DSC1 DSC3 DSG1 DSG3 DSG4

Drugs & Therapeutics for Pemphigus

Drugs for Pemphigus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 94)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
2
rituximab Approved Phase 3,Phase 2,Phase 1 174722-31-7 10201696
3
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3 50-02-2 5743
4
Mycophenolic acid Approved Phase 3 24280-93-1 446541
5
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
6
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
7
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
8
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
9
Prednisone Approved, Vet_approved Phase 3,Phase 2,Early Phase 1 53-03-2 5865
10
Acetaminophen Approved Phase 3 103-90-2 1983
11
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
12
Cetirizine Approved Phase 3 83881-51-0 2678
13 Alkylating Agents Phase 3,Phase 2
14 Gastrointestinal Agents Phase 2, Phase 3
15 Immunoglobulins Phase 3,Phase 2
16 Immunosuppressive Agents Phase 3,Phase 2,Early Phase 1
17 Antibodies Phase 3,Phase 2
18 Antirheumatic Agents Phase 3,Phase 2,Phase 1
19 triamcinolone acetonide Phase 3
20 Prednisolone acetate Phase 3,Phase 2
21 Dexamethasone acetate Phase 2, Phase 3 1177-87-3
22 Analgesics Phase 3,Phase 2
23 glucocorticoids Phase 3,Phase 2
24
protease inhibitors Phase 2, Phase 3
25 Methylprednisolone acetate Phase 3,Phase 2
26 Methylprednisolone Hemisuccinate Phase 3,Phase 2
27 Rho(D) Immune Globulin Phase 3,Phase 2
28 gamma-Globulins Phase 3,Phase 2
29 Triamcinolone diacetate Phase 3
30 Triamcinolone hexacetonide Phase 3
31 Analgesics, Non-Narcotic Phase 3,Phase 2
32 HIV Protease Inhibitors Phase 2, Phase 3
33 Hormone Antagonists Phase 3,Phase 2
34 Hormones Phase 3,Phase 2
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
36 Peripheral Nervous System Agents Phase 2, Phase 3
37 Antibodies, Monoclonal Phase 3,Phase 2
38 Anti-Bacterial Agents Phase 3,Phase 2,Early Phase 1
39 Antiemetics Phase 2, Phase 3
40 Anti-Infective Agents Phase 3,Phase 2,Early Phase 1
41 Immunoglobulins, Intravenous Phase 3,Phase 2
42 Prednisolone hemisuccinate Phase 3,Phase 2
43 Prednisolone phosphate Phase 3,Phase 2
44 Anti-Inflammatory Agents Phase 3,Phase 2
45 Antibiotics, Antitubercular Phase 3,Early Phase 1
46 Antineoplastic Agents, Hormonal Phase 2, Phase 3
47 BB 1101 Phase 2, Phase 3
48 Autonomic Agents Phase 2, Phase 3
49 Antitubercular Agents Phase 3
50 Neurotransmitter Agents Phase 3,Phase 1

Interventional clinical trials:

(show all 44)

# Name Status NCT ID Phase Drugs
1 Comparison of Two Therapeutic Strategies of Dermoval in Treatment of Bullous Pemphigus Completed NCT00213421 Phase 4 Dermoval
2 Comparative Study of Rituximab Versus Combination of Rituximab and Intravenous Cyclophosphamide in Severe Pemphigus Unknown status NCT01974518 Phase 3 Rituximab and Cyclophosphamide IV
3 Comparison Between Injections of Steroids and Autologous Platelet Rich Plasma in the Oral Erosions of Pemphigus Vulgaris Completed NCT02828163 Phase 3 Triamcinolone Acetonide
4 Comparison Between Rituximab Treatment and General Corticotherapy Treatment in Patients With Pemphigus Completed NCT00784589 Phase 3 General Corticotherapy;Rituximab
5 Long-term Clinical and Biological Evaluation of Patients With Severe Forms of Pemphigus Treated by Rituximab Completed NCT01299857 Phase 3 Rituximab
6 Effect of Anti CD20 in Pemphigus Desease Completed NCT00213512 Phase 2, Phase 3 Mabthera
7 European Trial of Adjuvant Oral Glucocorticoid Pulse Therapy in Pemphigus Completed NCT00127764 Phase 2, Phase 3 dexamethasone (50mg 1dd6, 3 consecutive days/month)
8 A Study to Assess the Effect of CellCept (Mycophenolate Mofetil) and Reduced Corticosteroids in Patients With Active Pemphigus Vulgaris (PV) Completed NCT00683930 Phase 3 Mycophenolate Mofetil 2 g/Day;Mycophenolate Mofetil (MMF) 3 g/Day;Placebo
9 Phase III Clinical Trial of NPB-01 in Patients With Bullous Pemphigoid Unresponsive to Corticosteroids Completed NCT01408550 Phase 3 NPB-01;Placebo
10 A Study to Evaluate the Efficacy and Safety of Rituximab Versus Mycophenolate Mofetil (MMF) in Participants With Pemphigus Vulgaris (PV) Recruiting NCT02383589 Phase 3 Mycophenolate Mofetil Placebo;Mycophenolate Mofetil;Rituximab;Rituximab Placebo
11 Pharmacokinetics Study of Mycophenolic Acid in Patients With an Autoimmune Bullous Dermatose, Pemphigus or Cicatricial Pemphigoid. Recruiting NCT02993133 Phase 3 Cellcept® in autoimmune bullous dermatoses
12 Efficacy and Safety of Ofatumumab in Treatment of Pemphigus Vulgaris Active, not recruiting NCT01920477 Phase 3
13 Long-Term Extension Study of Ofatumumab in Subjects With Pemphigus Vulgaris Terminated NCT02613910 Phase 3 Ofatumumab;Acetaminophen/paracetamol;Antihistamine (cetirizine or equivalent);Prednisone/Prednisolone
14 Use of KC706 for the Treatment of Pemphigus Vulgaris Completed NCT00606749 Phase 2 KC706
15 Immunoadsorption, Dexamethasone Pulse Therapy and Rituximab for Pemphigus Completed NCT00656656 Phase 2 Combination of Protein A Immunoadsorption, Rituximab, Dexamethasone plus Azathioprine
16 Azathioprine Versus Placebo in Pemphigus Vulgaris Treated With Prednisolone Completed NCT00626678 Phase 2 Azathioprine;Prednisone;Placebo
17 Study of Etanercept (Enbrel) in the Treatment of Pemphigus Vulgaris Completed NCT00135720 Phase 2 Enbrel (Etanercept)
18 Use of Infliximab for the Treatment of Pemphigus Vulgaris Completed NCT00283712 Phase 2 Infliximab
19 Phase II Study of High-Dose Cyclophosphamide in Patients With Refractory Pemphigus Completed NCT00010413 Phase 2 cyclophosphamide;filgrastim
20 Clinical Trial of NPB-01 in Patients With Bullous Pemphigoid Unresponsive to Corticosteroids. Completed NCT00809822 Phase 2 NPB-01;Placebo
21 Clinical Trial Evaluating Rituximab in Ocular Cicatricial Pemphigoid Completed NCT00584935 Phase 1, Phase 2 Rituximab
22 A Study to Evaluate the Safety, PD, PK and Efficacy of ARGX-113 in Patients With Pemphigus Vulgaris Recruiting NCT03334058 Phase 2 ARGX-113
23 A Study of PRN1008 in Adult Patients With Pemphigus Vulgaris Recruiting NCT02704429 Phase 2 PRN1008
24 Study of Efficacy and Safety of VAY736 in Patients With Pemphigus Vulgaris Active, not recruiting NCT01930175 Phase 2 VAY736;Placebo to VAY736;VAY736
25 Randomized Trial of IVIg With or Without Cyclophosphamide in Pemphigus Terminated NCT00483119 Phase 2 intravenous immunoglobulin;cyclophosphamide
26 Efficacy of Dapsone as a Steroid Sparing Agent in Pemphigus Vulgaris Terminated NCT00429533 Phase 2 Dapsone
27 Safety Study of PI-0824 to Treat Pemphigus Vulgaris Completed NCT00063752 Phase 1 PI-0824
28 A Safety Study of SYNT001 in Subjects With Pemphigus (Vulgaris or Foliaceus) Recruiting NCT03075904 Phase 1 SYNT001
29 Polyclonal Regulatory T Cells (PolyTregs) for Pemphigus Recruiting NCT03239470 Phase 1
30 Evaluation of the Improvement of Quality of Life of Patients Suffering From Hailey Hailey or Darier Disease After Injections of Botulism Toxin Into Large Folds. Active, not recruiting NCT02782702 Phase 1 Botulism Toxin Treatment
31 Hematopoietic Stem Cell Support in Patients With Autoimmune Bullous Skin Disorders Terminated NCT00278642 Phase 1
32 Treatment of Pemphigus Patients With Rituximab 1000mgX2 and Assessment of Immune Status Via Cylex Unknown status NCT01338103 Rituximab
33 Wound Dressings for Pemphigus and Pemphigoid Unknown status NCT02365675
34 Role of Proteasomes in a Dermatological Autoimmune Disease: Bullous Pemphigoid Unknown status NCT01559155
35 National Registry for Ichthyosis and Related Disorders Unknown status NCT00074685
36 Register of Autoimmune Bullous Dermatoses Completed NCT02899923
37 The RITAI Cohort: An Observational Study on Rituximab Off-label Use for Auto-immune Disorders Completed NCT00960713 Rituximab (MABTHERA® or RITUXAN®).
38 Identification of Vulnerability Factors in the Course of Pemphigus Patients Recruiting NCT02237313
39 Autoimmune Blistering Diseases Study Recruiting NCT02753777
40 Genetic Susceptibility and Influence of the Microbiomae in Bullous Pemphigoid Recruiting NCT02874079
41 Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases Recruiting NCT01952275
42 Serum IL-21 Levels in Patients With Pemphigus Vulgaris Not yet recruiting NCT03177213
43 Serum FFA Desaturase Activity Index in Patients on High Dose Corticosteroids Not yet recruiting NCT02872584 Prednisone
44 Evaluating Sirolimus to Treat Autoimmune Blistering Dermatosis Pemphigus Terminated NCT01313923 Early Phase 1 Sirolimus (formerly known as Rapamycin)

Search NIH Clinical Center for Pemphigus

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: pemphigus

Genetic Tests for Pemphigus

Anatomical Context for Pemphigus

MalaCards organs/tissues related to Pemphigus:

38
Skin, T Cells, Testes, Eye, B Cells, Neutrophil, Lung

Publications for Pemphigus

Articles related to Pemphigus:

(show top 50) (show all 2396)
# Title Authors Year
1
Patients affected by endemic pemphigus foliaceus in Colombia, South America exhibit autoantibodies to optic nerve sheath envelope cell junctions. ( 29445566 )
2018
2
Pemphigus herpetiformis with autoantibodies to desmocollins 1, 2 and 3. ( 29333762 )
2018
3
Intravenous immunoglobulin treatment abrogates transplacental autoantibody transfer in a murine pemphigus model. ( 29360528 )
2018
4
Reduced IgG anti-desmocollin autoantibody titre and concomitant improvement in a patient with pemphigus vegetans. ( 29336313 )
2018
5
Pemphigus vegetans with the manifestations of acrodermatitis continua: A rare variant. ( 29058326 )
2018
6
A prospective study comparing patients with early and late relapsing pemphigus treated with rituximab. ( 29408700 )
2018
7
Paraneoplastic pemphigus mimicking toxic epidermal necrolysis: An underdiagnosed entity? ( 29387753 )
2018
8
Diagnosis and Management of Pemphigus: recommendations by an International Panel of Experts. ( 29438767 )
2018
9
Tocilizumab Cannot Prevent the Development of Bronchiolitis Obliterans in Patients With Castleman Disease-Associated Paraneoplastic Pemphigus. ( 29389687 )
2018
10
A Case of Concomitant Pemphigus Foliaceus and Oral Pemphigus Vulgaris. ( 29340948 )
2018
11
Association between HLA-DQB1 polymorphisms and pemphigus vulgaris: A meta-analysis. ( 29182409 )
2018
12
Pemphigus trigger factors: special focus on pemphigus vulgaris and pemphigus foliaceus. ( 29110080 )
2018
13
Pemphigus herpetiformis resistant to first line therapy: a rare case in childhood. ( 29368854 )
2018
14
Rituximab and intravenous immunoglobulin as alternatives to long-term systemic corticosteroids in the treatment of pemphigus: a single center case series of 63 patients. ( 29447653 )
2018
15
Reflectance confocal microscopy and optical coherence tomography for the diagnosis of bullous pemphigoid and pemphigus and surrounding sub-clinical lesions. ( 29341355 )
2018
16
Image Gallery: Paraneoplastic pemphigus and follicular dendritic cell sarcoma. ( 29441554 )
2018
17
Pemphigus-A Disease of Desmosome Dysfunction Caused by Multiple Mechanisms. ( 29449846 )
2018
18
A case of pemphigus vulgaris associated with ulcerative colitis. ( 29422810 )
2018
19
Pemphigus Vulgaris and Radiotherapy. ( 29097073 )
2018
20
Autoimmunity and cardiac arrhythmias in endemic pemphigus foliaceus-Association, correlation, or causation? ( 29369789 )
2018
21
An Oral Disease Severity Score (ODSS) validated for use in oral pemphigus vulgaris. ( 29297927 )
2018
22
Sixteen-year history of rituximab therapy for 1085 pemphigus vulgaris patients: A systematic review. ( 29132070 )
2018
23
A rare presentation of congenital syphilis: Pemphigus syphiliticus in a newborn infant with extensive desquamation of the extremities. ( 29314211 )
2018
24
Paraneoplastic pemphigus without detectable anti-plakin antibodies in a patient with non-Hodgkin lymphoma. ( 29143865 )
2018
25
Pathogenic IgG4 autoantibodies from endemic pemphigus foliaceus recognize a desmoglein-1 conformational epitope. ( 29307589 )
2018
26
Paraneoplastic Pemphigus in a 34-year-old. ( 29447659 )
2017
27
Is there an association between pemphigus and hepatitis viruses? A population-based large-scale study. ( 28905194 )
2017
28
Successful treatment of pemphigus foliaceus in a Berrichon du Cher ram with methylprednisolone acetate. ( 28378419 )
2017
29
Myiasis in a neglected case of generalized erythrodermic pemphigus foliaceus. ( 28366917 )
2017
30
Anagener Haarverlust, Anti-Desmoglein 1 und Pemphigus Disease Area Index: Ein signifikanter Zusammenhang? ( 28872237 )
2017
31
Feasibility study for clinical application of caspase-3 inhibitors in Pemphigus vulgaris. ( 29105150 )
2017
32
Pemphigus Vulgaris and Pemphigus Foliaceus: Differences in Epidemiology and Mortality. ( 28536732 )
2017
33
Recurrent Paronychia as a Presenting Manifestation of Pemphigus Vulgaris: A Case Report. ( 28611998 )
2017
34
Is photodynamic therapy a relevant therapeutic option in refractory benign familial pemphigus (Hailey-Hailey disease)? A series of eight patients. ( 28301978 )
2017
35
Paraneoplastic pemphigus seen in four patients with haematological malignancies formerly treated with rituximab. ( 28758262 )
2017
36
Salivary Samples for the Diagnosis of Pemphigus vulgaris Using the BIOCHIP Approach: a Pilot Study. ( 28064226 )
2017
37
Location of oral lesions predicts treatment resistance in pemphigus vulgaris. ( 29313939 )
2017
38
Miniaturization of sebaceous glands: A novel histopathological finding in pemphigus vulgaris and pemphigus foliaceus of the scalp. ( 28632917 )
2017
39
Patients with a new variant of endemic pemphigus foliaceus have autoantibodies against arrector pili muscle, colocalizing with MYZAP, p0071, desmoplakins 1 and 2 and ARVCF. ( 29034528 )
2017
40
Anterior Scleritis Associated with Pemphigus Vulgaris. ( 29095065 )
2017
41
The Rare Case of Pemphigus Vegetans in Association with Malnutrition Children in the Multidisciplinary Management. ( 28559814 )
2017
42
A novel lateral flow immunoassay for the rapid detection of anti-Dsg3 IgG serum autoantibodies in pemphigus vulgaris. ( 29278440 )
2017
43
Association between schizophrenia and an autoimmune bullous skin disease-pemphigus: a population-based large-scale study. ( 28942756 )
2017
44
Jaw Pain in a Pemphigus Patient on Prednisolone, Mycophenolate Mofetil and Denosumab. ( 28920136 )
2017
45
Successful and well-tolerated bi-weekly immunoadsorption regimen in pemphigus vulgaris. ( 29096849 )
2017
46
Paraneoplastic pemphigus in two pairs of brothers. ( 28622444 )
2017
47
Using immune checkpoint inhibitors without exacerbation in a melanoma patient with pemphigus foliaceus. ( 28762466 )
2017
48
A reciprocal HLA-Disease Association in Rheumatoid Arthritis and Pemphigus Vulgaris. ( 27814654 )
2017
49
Evaluation of C-reactive protein as an inflammatory marker of pemphigus foliaceus and superficial pyoderma in dogs. ( 29168248 )
2017
50
Delayed and localized pemphigus vulgaris after breast cancer radiotherapy. ( 28892216 )
2017

Variations for Pemphigus

Expression for Pemphigus

Search GEO for disease gene expression data for Pemphigus.

Pathways for Pemphigus

GO Terms for Pemphigus

Cellular components related to Pemphigus according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.97 COL17A1 DSC1 DSC3 DSG1 DSG2 DSG3
2 cell-cell junction GO:0005911 9.73 COL17A1 DSC3 DSG1 DSG2 DSP JUP
3 ficolin-1-rich granule membrane GO:0101003 9.65 DSC1 DSG1 DSP
4 cornified envelope GO:0001533 9.65 DSC1 DSC3 DSG1 DSG2 DSG3 DSG4
5 lateral plasma membrane GO:0016328 9.63 DSG1 DSG2 JUP
6 intercalated disc GO:0014704 9.61 DSG2 DSP JUP
7 fascia adherens GO:0005916 9.51 DSP JUP
8 hemidesmosome GO:0030056 9.5 COL17A1 DST JUP
9 desmosome GO:0030057 9.32 DSC1 DSC3 DSG1 DSG2 DSG3 DSG4
10 membrane GO:0016020 10.34 ATP2C1 CD79A COL17A1 DSC1 DSC3 DSG1
11 integral component of membrane GO:0016021 10.26 ATP2C1 CD79A COL17A1 DSC1 DSC3 DSG1
12 plasma membrane GO:0005886 10.22 CD79A COL17A1 DSC1 DSC3 DSG1 DSG2
13 extracellular exosome GO:0070062 10.11 A2ML1 DSC1 DSG1 DSG2 DSG3 DSP

Biological processes related to Pemphigus according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.89 DSC1 DSG1 DSP JUP PLAUR
2 cell adhesion GO:0007155 9.86 DSC1 DSC3 DSG1 DSG2 DSG3 DSG4
3 cell-cell adhesion GO:0098609 9.73 DSG1 DSG4 DSP JUP
4 epidermis development GO:0008544 9.71 ATP2C1 COL17A1 DSP EVPL
5 keratinocyte differentiation GO:0030216 9.69 DSG4 DSP EVPL
6 cornification GO:0070268 9.65 DSC1 DSC3 DSG1 DSG2 DSG3 DSG4
7 regulation of heart rate by cardiac conduction GO:0086091 9.63 DSG2 DSP JUP
8 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.63 DSC1 DSC3 DSG1 DSG2 DSG3 DSG4
9 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339 9.55 ATP2C1 DSG1
10 maternal process involved in female pregnancy GO:0060135 9.54 DSG1 DSG2
11 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.54 DSG2 DSP JUP
12 intermediate filament cytoskeleton organization GO:0045104 9.52 DSP DST
13 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 9.5 DSG2 DSP JUP
14 desmosome organization GO:0002934 9.48 DSG2 DSP
15 keratinization GO:0031424 9.32 DSC1 DSC3 DSG1 DSG2 DSG3 DSG4

Molecular functions related to Pemphigus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.5 DSC1 DSC3 DSG1 DSG2 DSG3 DSG4
2 cell adhesion molecule binding GO:0050839 9.33 DSG2 DSP JUP
3 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 8.8 DSG2 DSP JUP

Sources for Pemphigus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
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50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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