Pemphigus malady

MedlinePlus: Pemphigus is an autoimmune disorder in which your antibodies attack healthy cells in your skin and mouth, causing blisters and sores. no one knows what causes this attack. pemphigus does not spread from person to person. it does not appear to be inherited. but some people's genes put them more at risk for pemphigus. pemphigoid is also an autoimmune skin disease. it leads to deep blisters that do not break easily. pemphigoid is most common in older adults and may be fatal. the treatment of pemphigus and pemphigoid is the same: one or more medicines. these may include steroids, which reduce inflammation drugs that suppress the immune system response antibiotics to treat associated infections nih: national institute of arthritis and musculoskeletal and skin diseases²³

MalaCards: Pemphigus, also known as pemphigus nos (disorder), is related to pemphigus foliaceus and pemphigus vulgaris. An important gene associated with Pemphigus is DSG3 (desmoglein 3), and among its related pathways are RAR-Gamma-RXR-Alpha Degradation and THC Differentiation Pathway. The drugs auranofin and chloroquine and the compounds cyclophosphamide and ivig have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and thymus, and related mouse phenotypes are respiratory system and craniofacial.

NIH Rare Diseases: Pemphigus is a group of rare autoimmune diseases that cause blistering of the skin and mucous membranes (mouth, nose, throat, eyes, and genitals). This condition can occur at any age, but often strikes people in middle or older age. It is more common in people of Middle Eastern or Jewish descent than in other races and cultures. Pemphigus is a chronic disease which is best controlled by early diagnosis and treatment. Treatment includes steroids to reduce inflammation, drugs that suppress the immune system response and antibiotics to treat associated infections. There are three main types of pemphigus: Pemphigus vulgaris Pemphigus foliaceus  Paraneoplastic pemphigus³⁰

Wikipedia: Pemphigus (⁴⁴ more...

Aliases & Descriptions:

pemphigus 6 30 32 23 43 pemphigus nos (disorder) 6

pemphigus (disorder) 6 pemphigus nos 6

Diseases related to pemphigus by text searches and GeneDecks gene sharing:

(show top 50)    (show all 976)

id	Related Disease	Score	Top Affiliating Genes
1	pemphigus foliaceus	36.4	UBE2S, BAX, CD79A, CD40LG, CD19, CD40
2	pemphigus vulgaris	36.0	CIITA, MTOR, JUP, CD79A, CDK2, CDH3
3	hailey-hailey disease	33.6	ATP2C1, JUP, CDH3, CDH1, IVL, GJA1
4	subcorneal pustular dermatosis	32.5	CD79A, DSC1, DSC3, DSG1, DSG3
5	bullous pemphigoid	32.1	BLZF1, CIITA, CD79A, IVL, ITGB4, IL5
6	dendritic cell sarcoma	30.7	EVPL, TP53, PPL, DSG1, DSG3, DSP
7	follicular dendritic cell sarcoma	29.9	EVPL, TP53, PPL, DSG1, DSG3, DSP
8	cicatricial pemphigoid	29.4	CD79A, ITGB4, COL17A1, DST
9	impetigo	28.6	CD79A, CD40LG, DSG1, DSG2, DSG3, DSG4
10	keratosis	28.0	JUP, IVL, FASLG, FAS, ALB, GJA1
11	mixed connective tissue disease	27.5	CD40LG, IL6, HSPG2, HLA-A, HLA-DQA1, HLA-DRB1
12	castleman's disease	27.3	IL10, IL5, IL6, IFNA1, ALB, EVPL
13	bronchiolitis obliterans	27.2	MMP9, IL10, IL1B, IL1RN, IL6, IFNA2
14	silicosis	26.8	JUN, JUP, IL10, IL1A, IL1B, IL1RAPL2
15	autoimmune hemolytic anemia	26.8	CD79A, CD40LG, IL10, IL2, IL4, IL5
16	hepatitis	26.6	FASLG, FAS, IFNA1, IFNA2, ALB, HLA-A
17	hemolytic anemia	26.3	CD40LG, IL10, IL2, IL4, IL5, FASLG
18	chronic lymphocytic leukemia	26.2	BLZF1, BAX, CDK2, CD40LG, CD19, CD40
19	connective tissue disease	25.6	BLZF1, CD79A, CD40LG, CD19, CD40, IL10
20	hepatitis c	25.4	CIITA, JUN, CD40LG, IL10, IL2, IL4
21	myasthenia gravis	24.4	CIITA, CD79A, CD40LG, MMP9, IL10, IL12A
22	papilloma	24.2	BAX, JUN, IVL, IL2, IFNA2, IFNG
23	thymoma	24.2	MMP9, IL1A, IL1R1, IL1RAPL2, IL2, FAS
24	blindness	23.2	CD79A, CD40LG, CDH3, MMP9, IL10, IL1A
25	skin disease	22.8	CIITA, ATP2C1, JUP, CD79A, CDH3, CD40
26	bronchiolitis	21.2	JUN, CD79A, CD40LG, CD40, CDH1, MMP9
27	anemia	21.1	BLZF1, MTOR, CD79A, CD40LG, CDH3, CD19
28	dermatitis	20.4	CIITA, JUN, CD79A, CD40LG, CD40, CDH1
29	inflammatory bowel disease	20.2	CIITA, JUN, JUP, CD79A, CD40LG, CD40
30	gingivitis	18.7	JUN, CD79A, CD40LG, CDH3, CD19, CD40
31	psoriasis	18.1	CIITA, CHRNA7, BAX, JUN, CD79A, CDK2
32	squamous cell carcinoma	18.1	BLZF1, BAX, MTOR, JUN, JUP, CDK2
33	lymphocytic leukemia	18.1	BLZF1, BAX, MTOR, CD79A, CDK2, CD40LG
34	sarcoma	17.9	BLZF1, CHRM1, BAX, MTOR, JUN, JUP
35	multiple myeloma	17.0	CIITA, BAX, MTOR, JUN, CD79A, CDK2
36	myeloma	16.1	BLZF1, CIITA, BAX, MTOR, JUN, CD79A
37	carcinoma	15.6	BLZF1, CIITA, UBE2S, BAX, MTOR, JUN
38	leukemia	14.3	BLZF1, BAX, MTOR, JUN, JUP, CD79A
39	mongolian spot	14.1	ATP2C1, JUP, CDH3, IVL, DSP
40	arthritis	14.0	IL1A, IL1B, IL6, TNF, PLAUR
41	palindromic rheumatism	14.0	IL1B, HLA-DRB1, TNF, PTPN22
42	acute disseminated encephalomyelitis	14.0	IL10, HLA-DQA1, HLA-DQB1, HLA-DRB1, TNF
43	skin conditions	14.0	ATP2C1, IL1A, IL6, IGHE, TNF
44	staphylococcal toxic shock syndrome	14.0	CIITA, IL1B, IGHE, TNF
45	leprosy	14.0	IL10, HLA-DQA1, HLA-DQB1, HLA-DRB1, LTA
46	monoclonal gammopathy of undetermined significance	13.9	CD79A, CD40LG, CDH1, IL1B, IL6, HLA-G
47	tubulointerstitial nephritis and uveitis	13.9	HLA-DQA1, HLA-DQB1, HLA-DRB1
48	vulvar vestibulitis syndrome	13.9	IL1B, IL1R1, IL1RN, MBL2, TNF
49	bagassosis	13.9	IL1B, IL5, IL6, TNF
50	primary systemic mycosis	13.9	CD79A, IL10, IL4, TNF

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 auranofin, aurothioglucose, chloroquine, chloroquine hydrochloride, chloroquine phosphate, potassium para-aminobenzoate

MalaCards organs/tissues related to pemphigus:

²²

MGI Mouse Phenotypes related to pemphigus:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.2	CHRNA7, CHRM1, IL12A, PTPN22, ACHE, C5
2	craniofacial phenotype	MP:0005382	10.0	DSC1, ACHE, GJA1, HSPG2, ATP2C1
3	endocrine/exocrine gland phenotype	MP:0005379	10.0	CD40LG, CDH3, IL2, FASLG, IFNG, GJA1
4	hematopoietic system phenotype	MP:0005397	9.7	CD19, IL12RB2, IL4R, IL5, PERP, DST
5	liver/biliary system phenotype	MP:0005370	9.3	IL6, IFNG, HSPG2, TRB@, TP53, PTPN22
6	normal phenotype	MP:0002873	9.2	GJA1, HLA-DQB1, TRB@, PTPN3, CTLA4, PPL
7	renal/urinary system phenotype	MP:0005367	9.0	C3, DST, EGFR, CTNNB1, CASP3, ITGB4
8	embryogenesis phenotype	MP:0005380	9.0	DSP, EGFR, PLCG1, CTNNB1, SRC, IL5
9	adipose tissue phenotype	MP:0005375	8.7	ACE, ACHE, DSG3, DSG4, TGFB1, C3
10	no phenotypic analysis	MP:0003012	8.2	DST, ACHE, EGFR, PLCB4, CTNNB1, PTPN3
11	integument phenotype	MP:0010771	8.0	DSC1, DSC3, DSG3, DSG4, DSP, DST
12	hearing/vestibular/ear phenotype	MP:0005377	7.9	CTNNB1, PLCG1, PLAU, EGFR, ACHE, GJA1
13	immune system phenotype	MP:0005387	7.7	CIITA, HLA-DQA1, HLA-DQB1, TRB@, TP53, TNF
14	reproductive system phenotype	MP:0005389	7.7	GJA1, TNF, SRC, NOS2, COL17A1, ACHE
15	digestive/alimentary phenotype	MP:0005381	7.6	CHRM1, CD19, CDH1, ITGB4, DST, TGFB1
16	tumorigenesis	MP:0002006	7.6	ATP2C1, CDK2, CD19, CDH1, MMP9, TRB@
17	nervous system phenotype	MP:0003631	7.2	RHOA, PLAUR, PLAU, CTNND1, LTA, EGFR
18	muscle phenotype	MP:0005369	7.1	TNF, CTNNB1, PLCB4, PLAU, PLAUR, NOS2
19	skeleton phenotype	MP:0005390	7.0	PTPN3, SRC, CTLA4, CTNNB1, PLAU, EGFR
20	mortality/aging	MP:0010768	6.0	CTLA4, DSG3, DSG4, DSP, DST, PERP
21	behavior/neurological phenotype	MP:0005386	5.6	PLCB4, CTNNB1, SRC, HLA-DQB1, HLA-C, PLAUR
22	vision/eye phenotype	MP:0005391	5.5	FAS, EGF, EGFR, ACHE, DSC1, DSG3
23	cardiovascular system phenotype	MP:0005385	5.2	IL10, IL12RB2, IL15, IL1A, IL1B, IL1R1
24	growth/size phenotype	MP:0005378	5.1	FAS, PLCB4, PLCG1, PLAU, PLAUR, COL17A1
25	homeostasis/metabolism phenotype	MP:0005376	4.3	CIITA, CHRNA7, CHRM1, BAX, MTOR, JUN
26	cellular phenotype	MP:0005384	3.7	TRB@, EGFR, EIF6, ACE, DSC1, DSG2

Articles related to pemphigus:

(show top 50)    (show all 458)

id	Title	Authors	Year	Affiliating Genes
1	p38 MAPK activation is downstream of the loss of inte rcellular adhesion in pemphigus vulgaris. (21078676)	Mao X.... Payne A.S.	2011	MAPK14
2	Binding of pemphigus vulgaris IgG to antigens in desm osome core domains excludes immune complexes rather than directly splitting des mosomes. (20222919)	Aoyama Y.... Kitajima Y.	2010	DSG1
3	Serum and salivary desmoglein 1 and 3 enzyme-linked i mmunosorbent assay in pemphigus vulgaris: correlation with phenotype and severi ty. (19709345)	Hallaji Z.... Chams-Davatchi C.	2010	DSG1
4	The value of desmoglein 1 and 3 antibody ELISA testing in patients with pemphigus. (19451505)	Zone J.J.	2009	DSG1
5	Interventions for pemphigus vulgaris and pemphigus fo liaceus. (19160272)	Martin L.K.... Murrell D.F.	2009	EGF
6	Desmoglein ELISA in the diagnosis of pemphigus and its correlation with the severity of pemphigus vulgaris. (19279360)	Mortazavi H.... Chams-Davatchi C.	2009	DSG1
7	Neonatal pemphigus in an infant born to a mother with serologic evidence of both pemphigus vulgaris and gestational pemphigoid. (19467379)	Panko J.... Vanderhooft S.	2009	DSG3
8	The IgM anti-desmoglein 1 response distinguishes Brazilian pemphigus foliaceus (fogo selvagem) from other forms of pemphigus. (17960181)	Diaz L.A.... Rivitti E.A.	2008	DSG1
9	Role of thiopurine methyltransferase activity in the safety and efficacy of azathioprine in the treatment of pemphigus vulgaris. (18794458)	Firooz A.... Karbakhsh Davari M.	2008	TPMT
10	Advances in pemphigus and its endemic pemphigus foliaceus (Fogo Selvagem) phenotype: a paradigm of human autoimmunity. (18838249)	Culton D.A.... Diaz L.A.	2008	DSG1, DSG3
11	IgG autoantibodies directed against desmoglein 3 cause dissociation of keratinocytes in canine pemphigus vulgaris and paraneoplastic pemphigus. (17350107)	Nishifuji K.... Amagai M.	2007	DSG1, DSG3
12	Coexistence of IgA antibodies to desmogleins 1 and 3 in pemphigus vulgaris, pemphigus foliaceus and paraneoplastic pemphigus. (17263817)	Mentink L.F.... Pas H.H.	2007	CD79A, DSG1, DSG3
13	Desmoglein versus non-desmoglein signaling in pemphigus acantholysis: characterization of novel signaling pathways downstream of pemphigus vulgaris antigens. (17344213)	Chernyavsky A.I.... Grando S.A.	2007	DSG3
14	Proteomic definition of a desmoglein linear determinant common to Pemphigus vulgaris and Pemphigus foliaceous. (16925820)	Lucchese A.... Kanduc D.	2006	DSG3
15	Simultaneous onset of pemphigus vulgaris in two Turkish siblings. (15863864)	Kavak A.... Gonen S.	2005	HLA-DQA1, HLA-DRB1
16	The interaction of pemphigus autoimmunoglobulins with epidermal cells: activation of the fas apoptotic pathway and the use of caspase activity for pathogenicity tests of pemphigus patients. (16014554)	Frusic-Zlotkin M.... Milner Y.	2005	DSG1, DSG3
17	Atypical IgA/IgG pemphigus involving the skin, oral mucosa, and colon in a child: a novel variant of IgA pemphigus? (16060868)	Bruckner A.L.... Morelli J.G.	2005	CD79A
18	Three cases of transition from pemphigus vulgaris to pemphigus foliaceus confirmed by desmoglein ELISA. (15942219)	Ng P.P.... Thng S.T.	2005	DSG3
19	The detection of IgG and IgA autoantibodies to desmocollins 1-3 by enzyme-linked immunosorbent assays using baculovirus-expressed proteins, in atypical pemphigus but not in typical pemphigus. (15270874)	Hisamatsu Y.... Hashimoto T.	2004	DSC3
20	Two Brazilian cases of IgA pemphigus. (14739515)	de Oliveira J.P.... Reis V.M.	2003	CD79A, PPL, DSC3
21	The plant lectin wheat germ agglutinin inhibits the binding of pemphigus foliaceus autoantibodies to desmoglein 1 in a majority of patients and prevents pathomechanisms of pemphigus foliaceus in vitro and in vivo. (14634141)	Ortiz-Urda S.... Rappersberger K.	2003	DSG1
22	Neonatal pemphigus vulgaris with extensive mucocutaneous lesions from a mother with oral pemphigus vulgaris. (12366435)	Campo-Voegeli A.... Camps A.	2002	DSG1, DSG3
23	The transition of pemphigus vulgaris into pemphigus foliaceus: a reflection of changing desmoglein 1 and 3 autoantibody levels in pemphigus vulgaris. (11966706)	Harman K.E.... Black M.M.	2002	DSG1, DSG3
24	Phosphatidylinositol-specific-phospholipase C cleaves urokinase plasminogen activator receptor from the cell surface and leads to inhibition of pemphigus-IgG-induced acantholysis in DJM-1 cells, a squamous cell carcinoma line. (11422178)	Asano S.... Kitajima Y.	2001	PLAU, PLCG1, PLAUR
25	Envoplakin and periplakin, the paraneoplastic pemphigus antigens, are also recognized by pemphigus foliaceus autoantibodies. (10951291)	Kazerounian S.... Aho S.	2000	PPL, EVPL
26	The distribution of pemphigus vulgaris-IgG subclasses and their reactivity with desmoglein 3 and 1 in pemphigus patients and their first-degree relatives. (10951142)	Kricheli D.... Milner Y.	2000	DSG3
27	Diagnosis of pemphigus by ELISA: a critical evaluation of two ELISAs for the detection of antibodies to the major pemphigus antigens, desmoglein 1 and 3. (10844505)	Harman K.E.... Black M.M.	2000	DSG1
28	Novel non-radioisotope immunoprecipitation studies indicate involvement of pemphigus vulgaris antigen in paraneoplastic pemphigus. (9673895)	Hashimoto T.... Chorzelski T.P.	1998	DSG3
29	The pathophysiological significance of nondesmoglein targets of pemphigus autoimmunity. Development of antibodies against keratinocyte cholinergic receptors in patients with pemphigus vulgaris and pemphigus foliaceus. (9722727)	Vu T.N.... Grando S.A.	1998	DSG1
30	Characterization of the regulatory regions in the human desmoglein genes encoding the pemphigus foliaceous and pemphigus vulgaris antigens. (9405290)	Adams M.J.... Ali R.R.	1998	DSG1, DSG3
31	Use of recombinant pemphigus vulgaris antigen in deve lopment of ELISA and IB assays to detect pemphigus vulgaris autoantibodies. (9552754)	Bhol K.... Ahmed A.R.	1998	DSG3
32	Antibodies against desmoglein 3 (pemphigus vulgaris antigen) are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice. (9710446)	Amagai M.... Hashimoto T.	1998	DSG1, PPL, DSG3
33	Herpetiform pemphigus showing reactivity with pemphigus vulgaris antigen (desmoglein 3) (9274636)	Kubo A.... Yoshikawa K.	1997	DSG3
34	Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. (9166409)	Koch P.J.... Stanley J.R.	1997	DSG3
35	Identification of a new antibody population directed against a desmosomal plaque antigen in pemphigus vulgaris and pemphigus foliaceus. (9077476)	Joly P.... Tron F.	1997	DSG1
36	Bullous pemphigoid and pemphigus vulgaris: correlated behaviour of serum VEGF, sE-selectin and TNF-alpha levels. (9582615)	Ameglio F.... Giacalone B.	1997	TNF
37	The location of binding sites of pemphigus vulgaris and pemphigus foliaceus autoantibodies: a post-embedding immunoelectron microscopic study. (9217820)	Zhou S.... Wojnarowska F.	1997	DSP
38	Recognition of pemphigus antigens in drug-induced pemphigus vulgaris and pemphigus foliaceus. (9204055)	Brenner S.... Anhalt G.J.	1997	DSG1, DSG3
39	Ultrastructural localisation of pemphigus vulgaris and pemphigus foliaceus antigens by indirect immunoelectron microscopy. Apropos of 7 cases (8526424)	Boulinguez S.... BonafAc J.L.	1995	DSG1
40	A simple epithelial cell line (MDCK) shows heterogeneity of desmoglein isoforms, one resembling pemphigus vulgaris antigen. (7615689)	Vilela M.J.... Garrod D.	1995	DSG3
41	Pemphigus foliaceus and pemphigus vulgaris autoantibodies react with the extracellular domain of desmoglein-1. (7860995)	Emery D.J.... Giudice G.J.	1995	DSG1
42	Immunofluorescence and immunoblot studies on the reactivity of pemphigus vulgaris and pemphigus foliaceus sera with desmoglein 3 and desmoglein 1. (8688919)	Hashimoto T.... Nishikawa T.	1995	DSG1, DSG3
43	A case of pemphigus vulgaris showing reactivity with pemphigus antigens (Dsg1 and Dsg3) and desmocollins. (7706774)	Hashimoto T.... Nishikawa T.	1995	DSG1, DSG3
44	Ultrastructural study of pemphigus foliaceus and pemphigus vulgaris antigens. Apropos of 2 cases (1724140)	Bedane C.... Bonnetblanc J.M.	1991	DSG3
45	Ultrastructural localization of pemphigus vulgaris and pemphigus foliaceus antigens in cultured human squamous carcinoma cells. (1911315)	Akiyama M.... Nishikawa T.	1991	DSG1
46	Desmoplakin I and II in acantholytic dermatoses: preservation in pemphigus vulgaris and pemphigus erythematosus and dissolution in Hailey-Hailey's disease and Darier's disease. (2054341)	Setoyama M.... Etoh H.	1991	DSP
47	Can pemphigus vulgaris become pemphigus foliaceus? (1802901)	Iwatsuki K.... Yamada M.	1991	DSG1
48	Regional variation in the expression of pemphigus foliaceus, pemphigus erythematosus, and pemphigus vulgaris antigens in human skin. (1991976)	Ioannides D.... Bystryn J.C.	1991	DSG3
49	Coexistence of pemphigus foliaceus and bullous pemphigoid. Demonstration of autoantibodies that bind to both the pemphigus foliaceus antigen complex and the bullous pemphigoid antigen. (1998370)	Korman N.J.... Woodley D.T.	1991	DST
50	Detection of pemphigus vulgaris and pemphigus foliaceus antigens by immunoblot analysis using different antigen sources. (2307852)	Hashimoto T.... Nishikawa T.	1990	DSG1

Genes related to pemphigus according to GeneCards:

(show top 50)    (show all 111)

id	Symbol	Description	Score	GeneCards Section Context
1	DSG3	desmoglein 3	11.1	Summaries, UniProt Related, Aliases & Descriptions, Functions (show all 5 sections) Publications
2	DSG1	desmoglein 1	11.1	Summaries, Aliases & Descriptions, Publications, Functions
3	DSP	desmoplakin	11.1	Publications, Aliases & Descriptions, Summaries
4	EVPL	envoplakin	11.1	Functions, Aliases & Descriptions, Publications
5	A2ML1	alpha-2-macroglobulin-like 1	11.0	Publications, Summaries
6	ATP2C1	ATPase, Ca++ transporting, type 2C, member 1	11.0	Aliases & Descriptions, Publications
7	PPL	periplakin	11.0	Functions, Publications
8	DSG2	desmoglein 2	11.0	Publications
9	DST	dystonin	11.0	Publications
10	PLAUR	plasminogen activator, urokinase receptor	11.0	Publications
11	DSG4	desmoglein 4	11.0	Publications
12	IVL	involucrin	11.0	Publications
13	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
14	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications
15	DSC3	desmocollin 3	11.0	Publications
16	JUP	junction plakoglobin	11.0	Publications
17	CDH3	cadherin 3, type 1, P-cadherin (placental)	11.0	Publications
18	TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b	11.0	Publications
19	IL1A	interleukin 1, alpha	11.0	Publications
20	PLAU	plasminogen activator, urokinase	11.0	Publications
21	CIITA	class II, major histocompatibility complex, transactivator	11.0	Publications
22	IL4R	interleukin 4 receptor	11.0	Publications
23	HLA-G	major histocompatibility complex, class I, G	11.0	Publications
24	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	11.0	Publications
25	CDH1	cadherin 1, type 1, E-cadherin (epithelial)	11.0	Publications
26	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
27	IL10	interleukin 10	11.0	Publications
28	MAPK14	mitogen-activated protein kinase 14	11.0	Publications
29	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
30	TNF	tumor necrosis factor	11.0	Publications
31	IL1B	interleukin 1, beta	11.0	Publications
32	ANXA9	annexin A9	11.0	Functions, Publications
33	DSC1	desmocollin 1	11.0	Publications
34	CHRNA9	cholinergic receptor, nicotinic, alpha 9 (neuronal)	11.0	Publications
35	PRSS2	protease, serine, 2 (trypsin 2)	11.0	Publications
36	PERP	PERP, TP53 apoptosis effector	11.0	Publications
37	EIF6	eukaryotic translation initiation factor 6	11.0	Publications
38	UBE2S	ubiquitin-conjugating enzyme E2S	11.0	Publications
39	MASP2	mannan-binding lectin serine peptidase 2	11.0	Publications
40	RNPC3	RNA-binding region (RNP1, RRM) containing 3	11.0	Publications
41	CD19	CD19 molecule	11.0	Publications
42	BLZF1	basic leucine zipper nuclear factor 1	11.0	Publications
43	IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	11.0	Publications
44	PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	11.0	Publications
45	TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	11.0	Publications
46	IL12RB2	interleukin 12 receptor, beta 2	11.0	Publications
47	TPMT	thiopurine S-methyltransferase	11.0	Publications
48	C3	complement component 3	11.0	Publications
49	LTA	lymphotoxin alpha (TNF superfamily, member 1)	11.0	Publications
50	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications

Pathways related to pemphigus according to GeneDecks:

(show top 50)    (show all 209)

id	Pathway	Score	Top Affiliating Genes
1	RAR-Gamma-RXR-Alpha Degradation36	10.4	TNFSF13B, IL12A, IL15, IL2, MAPK14, LTA
2	THC Differentiation Pathway36	10.4	IL10, HLA-DQA1, HLA-DQB1, IFNG, TNF, HLA-DRB1
3	Asthma20	10.4	CD40LG, CD40, IL10, IL4, IL5, HLA-DQB1
4	Immune System38	10.4	IL5, IFNG, HLA-G, CTLA4, IL1R1, CDH1
5	Antigen processing and presentation20	10.2	HLA-C, HSPA8, HLA-DQB1, TAP2, HLA-G, HLA-DQA1
6	PGC1Alpha Pathway36	10.2	MAPK14, TNFSF13B, IL5, IL4R, IL4, IL1R1
7	Akt Signaling36	10.2	IL4, IL6, LTA, TNFSF13B, TNF, IL2
8	Intestinal immune network for IgA production20	10.2	IL2, CD40LG, CD40, IL10, IL15, IL4
9	Graft-versus-host disease20	10.2	HLA-G, HLA-DQA1, HLA-C, HLA-B, IL1A, IL2
10	Regulation of eIF4 and p70S6K36	10.1	IL4, EGF, IL2, IL5, IL6, MAPK14
11	Type I diabetes mellitus20	9.8	HLA-DQB1, HLA-DRB1, LTA, TNF, HLA-G, HLA-DQA1
12	African trypanosomiasis20	9.8	IL10, TNF, IFNG, FAS, FASLG, IL6
13	all-trans-Retinoic Acid Signaling in Brain36	9.8	IL6, LTA, TNFSF13B, TNF, BAX, IL12A
14	MIF Mediated Glucocorticoid Regulation36	9.6	IL4, TNFSF13B, TNF, IL2, MAPK1, LTA
15	Cytokine Network36	9.6	LTA, TNF, IFNG, IFNA2, IFNA1, IL6
16	Allograft rejection20	9.5	CD40, CD40LG, HLA-DQA1, HLA-C, HLA-DQB1, HLA-DRB1
17	Rheumatoid arthritis20	9.5	IL1A, JUN, IL15, HLA-DQA1, IL1B, TGFB1
18	PEDF Induced Signaling36	9.5	LTA, IL2, IL4, TNFSF13B, TNF, IL5
19	Amoebiasis20	9.4	NOS2, PLCB4, IL12A, IL1B, IL1R1, IL6
20	STAT3 Pathway36	9.2	IL15, IL1A, IL1B, IL1R1, IL2, IL4
21	IL-6 Pathway36	9.2	BAX, MAPK1, IL5, IL4, IL12A, IL10
22	Tec Kinases Signaling36	9.1	TNFSF13B, IL2, IL15, IL12A, IL10, BAX
23	Measles20	9.1	FASLG, IL6, HSPA8, IFNA1, IL12A, TP53
24	Autoimmune thyroid disease20	8.9	CTLA4, TPO, HLA-G, HLA-DRB1, HLA-DQB1, HLA-DQA1
25	MIF Regulation of Innate Immune Cells36	8.8	LTA, TNFSF13B, TNF, MAPK1, IL6, IL5
26	TRAF Pathway36	8.7	SRC, TNFSF13B, LTA, MAPK14, CASP3, TRAF1
27	Glucocorticoid Receptor Signaling36	8.7	IL12A, IL15, IL1A, IL1B, IL1R1, IL2
28	Immune response IL-22 signaling pathway10	8.7	HLA-DRB1, HLA-DQB1, HLA-DQA1, MAPK1, TRB@, MAPK14
29	Toxoplasmosis20	8.5	IFNG, HSPA8, CASP3, HLA-DQA1, HLA-DQB1, HLA-DRB1
30	Natural killer cell mediated cytotoxicity20	8.4	IFNA1, MAPK1, IFNA2, IFNG, HLA-A, HLA-B
31	Cytokine-cytokine receptor interaction20	8.4	CD40LG, CD40, IL10, IL12A, IL12RB2, IL15
32	Leishmaniasis20	8.4	JUN, IL10, IL12A, IL1A, IL1B, IL4
33	Rho Family GTPases36	8.2	IL15, IL1A, IL1B, IL2, IL4, MAPK1
34	T cell receptor signaling pathway20	8.2	IFNG, JUN, CD40LG, MAPK1, RHOA, PLCG1
35	Endothelin-1 Signaling Pathway36	8.2	IL5, IL4, IL2, IL1B, IL1A, IL12A
36	TGF-Beta Pathway36	8.1	BAX, JUN, CDH1, IL10, IL12A, IL15
37	Influenza A20	8.0	CIITA, JUN, IL12A, IL1A, IL1B, IL6
38	MAPK Family Pathway36	8.0	HSPB1, TNF, TNFSF13B, LTA, EGF, EGFR
39	p38 Signaling36	7.9	BAX, IL10, IL12A, IL12RB2, IL15, IL1A
40	Pertussis20	7.9	C3, C5, RHOA, NOS2, JUN, IL10
41	Chagas disease (American trypanosomiasis)20	7.8	MAPK1, IFNG, TNF, PLCB4, NOS2, ACE
42	Colorectal Cancer Metastasis36	7.8	TNF, MAPK1, CDH1, IFNG, CASP3, BAX
43	ERK Signaling36	7.6	MAPK1, IL6, IL5, IL4, IL2, HSPG2
44	Tuberculosis20	7.4	MAPK14, MAPK1, IFNA1, IFNA2, IFNG, CASP3
45	Antioxidant Action of Vitamin-C36	7.4	PLCB4, TNF, TNFSF13B, PLCG1, MAPK1, LTA
46	JAK-STAT Pathway36	7.3	IL10, IL12A, IL15, IL1A, IL1B, IL1R1
47	MAPK signaling pathway20	7.3	MAPK1, JUN, IL1A, IL1B, TNF, TGFB1
48	MAPK Signaling36	6.6	TP53, PLCB4, PLCG1, COL17A1, LTA, EGF
49	Molecular Mechanisms of Cancer36	6.4	IL15, TGFB1, EGFR, EGF, IL1R1, IL2
50	Pathways in cancer20	6.4	RHOA, EGF, EGFR, TGFB1, BAX, NOS2

Compounds related to pemphigus according to GeneDecks:

(show top 50)    (show all 427)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.7	MBL2, TRB@, TPMT
2	ivig32	10.4	FCGRT, IL1RAPL2, FASLG, CRP, LTA, DSG1
3	egcg32	10.2	CDK2, IVL, IL1A, MAPK14, HSPG2, CAT
4	polyethylene glycol32	10.1	CDH1, IFNA2, PLCG1
5	endotoxin32	10.0	CIITA, CD40, IL1R1, IL1RAPL2, FASLG, MAPK14
6	gm-csf32	10.0	IL10, IL15, IL1A, IL1B, IL2, IL4
7	okt332	9.9	CD79A, CD40LG, IL10, IL15, IL2, IL6
8	fibrinogen32	9.9	CD79A, CD40LG, CD40, FCN2, IL1R1, IL1RAPL2
9	hydrocortisone32 9 9	11.7	CD40, IVL, IL10, IL15, IL1A, IL1B
10	etanercept32 9 9	11.6	IL10, IL15, IL1B, IL1R1, IL1RAPL2, IL1RN
11	h2o232	9.6	BLZF1, CD79A, CD40, IL1RAPL2, IL1RN, IL5
12	progesterone32 42 9 18 9	13.6	CDK2, CDH3, HSPB1, GJA1, CTNNB1, PLAU
13	tgf beta132	9.5	BLZF1, CDK2, CDH1, IL10, IL15, IL1RAPL2
14	rapamycin32 42	10.4	MTOR, CDK2, IL1R1, IL2, IFNG, HSPB1
15	methotrexate32 34 42 9 9	13.4	CD79A, CD40, CDH1, IVL, MMP9, IL10
16	aspartate32	9.4	CHRNA7, CD40LG, CDH1, MMP9, FASLG, MBL2
17	12-o-tetradecanoylphorbol 13-acetate32	9.3	CDH1, IVL, MMP9, IL1A, IL1R1, IL1RAPL2
18	ribonucleic acid32	9.2	BLZF1, CIITA, CD40, MMP9, IL15, IL1A
19	creatinine32	9.2	CD79A, CDK2, CD40LG, CD40, CDH1, MMP9
20	neopterin32	8.9	CD79A, CD40LG, CD40, IL10, IL1A, IL1B
21	lactate32	8.9	BLZF1, CD79A, CD40LG, CDH1, IVL, MMP9
22	simvastatin32 34 42 9 18 9	13.8	CIITA, CD40, MMP9, IL10, IL1A, IL1RAPL2
23	polyinosinic-polycytidylic acid32	8.8	CIITA, CD40, IL10, IL15, IL2, IL4
24	heparin32 9 18 9	11.8	CD79A, CDK2, CDH1, IL1RAPL2, IL1RN, ALB
25	pge232	8.5	CIITA, CHRNA7, CDH1, IVL, IL1A, IL1R1
26	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32	8.5	BAX, CD40, MMP9, IL1A, FASLG, FAS
27	c2ceramide32	8.4	BAX, JUN, IL1B, MAPK14, HSPB1, CASP3
28	fmlp32	8.1	IL1A, IL1B, IL1RAPL2, IL1RN, IL5, MAPK14
29	oligonucleotide32	8.1	CIITA, JUN, JUP, CD40, IVL, IL15
30	testosterone32 9 18 9	11.0	BLZF1, MTOR, CD79A, CDK2, CD40LG, CDH1
31	15-deoxy-delta-12,14-prostaglandin j232	8.0	JUN, CDK2, IL10, IL1B, IL4, IL6
32	rantes32	7.7	CIITA, JUN, CD40LG, CD40, MMP9, IL15
33	glutamate32	7.4	BLZF1, CHRM1, CD79A, CDK2, CD40, CDH1
34	pdtc32	7.3	JUN, CD40, MMP9, IL1A, IL1B, IL4
35	diphenyleneiodonium32	7.3	JUN, IL1B, IL1R1, MAPK14, MAPK1, CASP3
36	alanine32	7.2	BLZF1, CIITA, CHRNA7, CHRM1, CDK2, CD40LG
37	triptolide32	7.2	BAX, JUN, CD40, IL1B, IL2, IL6
38	cysteine32	7.1	BLZF1, CHRNA7, CD79A, CD40LG, CD40, CDH1
39	ly29400232	7.0	JUN, CDH1, MMP9, IL10, IL1B, IL4
40	quercetin32 42 9 18 9	11.0	BAX, JUN, CDK2, IL10, IL1B, IL2
41	thymidine32 18	7.8	CIITA, JUN, CDK2, CD40, IVL, IL10
42	tamoxifen32 34 9 9	9.8	BAX, MTOR, JUN, CDK2, CDH1, IL2
43	arsenite32 18	7.8	BAX, MTOR, JUN, CDK2, MMP9, FASLG
44	vegf32	6.6	MTOR, JUP, CDK2, CD40LG, CD40, CDH1
45	curcumin32	6.2	BAX, JUN, CDK2, CDH1, IVL, MMP9
46	pd 98,05932	5.1	BAX, MTOR, JUN, CDK2, CD40, CDH1
47	phosphatidylinositol32	4.3	BLZF1, CIITA, CHRNA7, CHRM1, BAX, MTOR
48	cycloheximide32	3.6	BLZF1, CIITA, BAX, JUN, CDK2, CD40
49	serine32	2.7	BLZF1, CIITA, CHRNA7, MTOR, JUN, JUP
50	tyrosine32	2.5	BLZF1, CIITA, CHRNA7, CHRM1, MTOR, ATP2C1

Cellular components related to pemphigus according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	desmosome	GO:030057	10.6	EVPL, PPL, DSC1, DSC2, DSC3, DSG1
2	hemidesmosome	GO:030056	10.2	DST, COL17A1, ITGB4, JUP
3	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.1	HLA-G, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C, HLA-B
4	ER to Golgi transport vesicle membrane	GO:012507	10.1	HLA-G, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C, HLA-B
5	cell-cell adherens junction	GO:005913	10.0	DSC2, CTNND1, CTNNB1, CDH1, CDH3, JUP
6	external side of plasma membrane	GO:009897	10.0	ACE, CTLA4, TNF, HLA-DRB1, IFNG, FAS
7	internal side of plasma membrane	GO:009898	9.9	DSG1, PTPN3, PTPN22, CDH1, JUP
8	MHC class I protein complex	GO:042612	9.8	HLA-G, HLA-C, HLA-B, HLA-A, FCGRT
9	cell surface	GO:009986	9.8	TGFB1, PLAUR, PLAU, TNF, TPO, HSPA8
10	cell-cell junction	GO:005911	9.8	DSG2, DSG1, DSC3, COL17A1, CTNND1, CTNNB1
11	integral to plasma membrane	GO:005887	9.1	HLA-C, HLA-DQA1, HLA-DRB1, TPO, TNF, CTLA4
12	extracellular region	GO:005576	8.3	RNASE3, PLAUR, PLAU, CRP, HLA-C, HSPG2
13	extracellular space	GO:005615	7.8	IL1RN, IL2, IL4, IL5, IL6, FASLG
14	cytosol	GO:005829	5.3	CAT, GJA1, TP53, TPMT, SRC, CTNNB1
15	plasma membrane	GO:005886	5.2	DSG4, DSP, PERP, C3, CHRNA9, DSG3

Biological processes related to pemphigus according to GeneDecks:

(show top 50)    (show all 62)

id	Name	GO ID	Score	Top Affiliating Genes
1	homophilic cell adhesion	GO:007156	10.7	DSG4, DSG3, DSG2, DSG1, DSC3, DSC2
2	chronic inflammatory response to antigenic stimulus	GO:002439	10.7	IL1RN, IL1B
3	B cell proliferation	GO:042100	10.7	IL10, CD40, CD40LG, CD79A
4	negative regulation of growth of symbiont in host	GO:044130	10.6	LTA, TNF, IFNG, MBL2, IL10
5	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	10.6	TNF, IFNG, IL1B
6	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	10.6	TNF, IL6, IL5, IL4, IL1B, IL10
7	positive regulation of MHC class II biosynthetic process	GO:045348	10.6	IFNG, IL4, IL10, CD40LG, CIITA
8	positive regulation of interferon-gamma production	GO:032729	10.6	LTA, TNF, IL2, IL1B, IL12RB2, IL12A
9	positive regulation of chemokine biosynthetic process	GO:045080	10.6	TNF, IFNG, IL4, IL1B
10	defense response to Gram-positive bacterium	GO:050830	10.5	IL12A, IL6, MBL2, TNF, LTA
11	positive regulation vascular endothelial growth factor production	GO:010575	10.5	C3, C5, TGFB1, IL1B, IL1A
12	positive regulation of T cell proliferation	GO:042102	10.5	IFNG, IL6, IL4, IL1B, IL15, IL12A
13	positive regulation of isotype switching to IgG isotypes	GO:048304	10.5	IFNG, IL4, IL2, CD40
14	adherens junction organization	GO:034332	10.4	DSP, CTNND1, CDH1, CDH3, JUP
15	regulation of protein localization to cell surface	GO:2000008	10.4	EGF, CTNNB1, CDH1
16	positive regulation of B cell proliferation	GO:030890	10.3	IL5, IL4, IL2, CD40, CD40LG
17	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	GO:002480	10.3	HLA-G, HLA-C, HLA-B, HLA-A
18	positive regulation of NF-kappaB transcription factor activity	GO:051092	10.3	IL6, CAT, TRAF1, TNF, TGFB1, IL1B
19	interferon-gamma-mediated signaling pathway	GO:060333	10.2	HLA-G, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C, HLA-B
20	keratinocyte differentiation	GO:030216	10.2	DSP, DSG4, CTNND1, EVPL, CASP3, IVL
21	cellular component disassembly involved in apoptotic process	GO:006921	10.2	DSP, DSG3, DSG2, DSG1, CTNNB1, CASP3
22	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	10.1	RHOA, TNF, TRAF1, GJA1, FASLG, IL1B
23	regulation of immune response	GO:050776	10.1	C3, HLA-G, HLA-C, HLA-B, HLA-A, IL4
24	positive regulation of angiogenesis	GO:045766	10.1	C3, C5, PLCG1, IL1B, IL1A, MMP9
25	T cell costimulation	GO:031295	10.0	CTLA4, SRC, HLA-DRB1, HLA-DQB1, HLA-DQA1, MTOR
26	positive regulation of apoptotic process	GO:043065	10.0	CTNNB1, CTLA4, TNF, TP53, FAS, FASLG
27	cell junction assembly	GO:034329	10.0	JUP, CDH3, CDH1, ITGB4, CTNND1, COL17A1
28	cell-cell adhesion	GO:016337	9.9	DSP, DSG1, EGFR, CTNND1, CTNNB1, ANXA9
29	inflammatory response	GO:006954	9.9	IFNA2, TNF, CRP, TGFB1, C5, C3
30	positive regulation of MAP kinase activity	GO:043406	9.7	TGFB1, EGFR, EGF, TNF, CD40
31	response to hypoxia	GO:001666	9.6	TGFB1, LTA, NOS2, CRP, TNF, CAT
32	cytokine-mediated signaling pathway	GO:019221	9.5	HLA-B, HLA-C, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-G
33	induction of apoptosis via death domain receptors	GO:008625	9.5	TNF, CASP3, FAS, FASLG
34	immune response	GO:006955	9.5	CIITA, HLA-A, HLA-B, HLA-C, HLA-DQA1, HLA-DQB1
35	cell surface receptor signaling pathway	GO:007166	9.5	C5, EGFR, IFNG, IFNA2, MAPK14, IL1R1
36	positive regulation of cell proliferation	GO:008284	9.4	FASLG, TNFSF13B, EGF, EGFR, TGFB1, IL6
37	cell adhesion	GO:007155	9.3	DSC2, DSC3, DSG2, DST, PERP, ACHE
38	negative regulation of apoptotic process	GO:043066	9.3	EGFR, PLAUR, TNF, TP53, CAT, CASP3
39	response to lipopolysaccharide	GO:032496	9.2	LTA, FAS, FASLG, IL1A, IL12A, MMP9
40	positive regulation of neuron apoptotic process	GO:043525	9.2	TNF, CASP3, FASLG, JUN, BAX
41	response to drug	GO:042493	9.2	IFNG, TNF, CTNNB1, LTA, TGFB1, FAS
42	platelet activation	GO:030168	9.1	TGFB1, EGF, RHOA, SRC, ALB, MAPK1
43	positive regulation of transcription, DNA-dependent	GO:045893	9.1	TGFB1, EGF, CTNNB1, TNF, TP53, IL6
44	induction of apoptosis	GO:006917	8.9	C5, PERP, TGFB1, LTA, TNF, CASP3
45	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.8	MAPK14, IFNG, TP53, TNF, CTNNB1, TGFB1
46	apoptotic process	GO:006915	8.6	TRAF1, TP53, TNF, CTNNB1, DSG1, DSG2
47	innate immune response	GO:045087	8.5	C3, C5, PRSS2, IFNA2, MAPK1, MAPK14
48	virus-host interaction	GO:019048	8.3	TGFB1, RHOA, PLCG1, SRC, TP53, HLA-C
49	blood coagulation	GO:007596	8.1	PLAU, PLAUR, NOS2, RHOA, EGF, TGFB1
50	signal transduction	GO:007165	7.8	TRAF1, TNFSF13B, SRC, PLCG1, PLAU, PLAUR

Molecular functions related to pemphigus according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	tumor necrosis factor receptor binding	GO:005164	10.2	LTA, TNFSF13B, TNF, FASLG, CD40LG
2	growth factor activity	GO:008083	9.9	TGFB1, EGF, IL6, IL5, IL4, IL2
3	MHC class I receptor activity	GO:032393	9.7	HLA-G, HLA-C, HLA-B, HLA-A
4	cytokine activity	GO:005125	9.6	CD40LG, LTA, TNFSF13B, TNF, IFNG, IFNA2
5	protein phosphatase binding	GO:019903	9.5	JUP, CDH1, CTNNB1, CTNND1, EGFR
6	calcium ion binding	GO:005509	9.5	DSC2, DSC3, DSG1, DSG2, DSG3, DSG4
7	receptor binding	GO:005102	8.0	TNFSF13B, SRC, CTNND1, NOS2, LTA, C5
8	protein binding	GO:005515	2.4	CTLA4, CTNNB1, CTNND1, PPL, CRP, PLCG1