MCID: PMP004
MIFTS: 42

Pemphigus Foliaceus malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Pemphigus Foliaceus

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Sources:
33LifeMap Discovery®, 46NIH Rare Diseases, 52Orphanet, 48Novoseek, 66UMLS, 67UMLS via Orphanet, 29ICD10 via Orphanet, 28ICD10
See all MalaCards sources

Aliases & Descriptions for Pemphigus Foliaceus:

Name: Pemphigus Foliaceus 33 46 52 48 66
 
Pf 46

Classifications:

Orphanet: 52 
Rare skin diseases


External Ids:

Orphanet52 ORPHA79481
UMLS via Orphanet67 C0263313
ICD10 via Orphanet29 L10.2
ICD1028 L10.2

Summaries for Pemphigus Foliaceus

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Wikipedia:69 Pemphigus foliaceus is an autoimmune blistering disease of the skin with characteristic lesions that are... more...

MalaCards based summary: Pemphigus Foliaceus, also known as pf, is related to impetigo and skin disease, and has symptoms including acantholysis, Array and Array. An important gene associated with Pemphigus Foliaceus is DSG1 (Desmoglein 1), and among its related pathways are Staphylococcus aureus infection and IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types. Affiliated tissues include skin, neutrophil and t cells, and related mouse phenotype integument.

Related Diseases for Pemphigus Foliaceus

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Diseases related to Pemphigus Foliaceus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 174)
idRelated DiseaseScoreTop Affiliating Genes
1impetigo30.7DSG1, DST
2skin disease29.7IL1B, IL4R
3rheumatoid arthritis28.1CTLA4, HLA-DRB1, IL1A, IL1B, IL1RN
4pemphigus11.6
5pemphigus and fogo selvagem11.4
6pemphigus vulgaris10.8
7herpetiform pemphigus10.7
8peripheral t-cell lymphoma10.5DSG1, HLA-DRB1
9autosomal recessive congenital methemoglobinemia10.5CTLA4, HLA-DRB1
10krieble bixler syndrome10.5CTLA4, HLA-DRB1
11sacrococcygeal dysgenesis association10.5DSG1, DST
12abdominal chemodectomas with cutaneous angiolipomas10.5CTLA4, HLA-DRB1
13panuveitis10.5CTLA4, HLA-DRB1
14giant ganglionic hyperplasia10.5DST, HLA-DRB1
15idiopathic central precocious puberty10.5CTLA4, HLA-DRB1
16autism spectrum disorder10.5DSG1, DST
17hemophagocytic lymphohistiocytosis10.4CTLA4, HLA-DRB1
18malignant histiocytosis10.4DSG1, DST
19bullous pemphigoid10.4
20puerperal pulmonary embolism10.4DSG1, DST
21proximal symphalangism10.4CTLA4, HLA-DRB1
22iridocyclitis10.4CTLA4, HLA-DRB1
23psoriasis10.3
24chancroid10.3CTLA4, HLA-DRB1
25epstein-barr virus hepatitis10.3HLA-DRB1, IL1A
26myasthenia gravis10.3
27dermatitis10.3
28paraneoplastic pemphigus10.3
29hereditary conventional renal cell carcinoma10.2CTLA4, HLA-DRB1
30thymoma10.2
31bartter disease10.2CTLA4, HLA-DRB1
32cirrhotic cardiomyopathy10.2DSG1, DST, HLA-DRB1
33subcorneal pustular dermatosis10.2DSG1, DST, HLA-DRB1
34diabetic macular edema10.2DSG1, DST, HLA-DRB1
35dermatitis herpetiformis, familial10.2HLA-DRB1, IL1RN
36conventional leiomyosarcoma10.1HLA-DRB1, IL1B
37spastic paraplegia-paget disease of bone syndrome10.1HLA-DRB1, IL1B
38systemic lupus erythematosus10.1
39alopecia10.1
40arthritis10.1
41lymphoma10.1
42lupus erythematosus10.1
43hidradenitis suppurativa10.0HLA-DRB1, IL1B
44nephrosclerosis10.0HLA-DRB1, IL1B
45hepatitis10.0
46dermatomyositis10.0
47sarcoma10.0
48prostatitis10.0
49acanthosis nigricans10.0
50porokeratosis10.0

Graphical network of the top 20 diseases related to Pemphigus Foliaceus:



Diseases related to pemphigus foliaceus

Symptoms for Pemphigus Foliaceus

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Symptoms:

 52
  • crusting erythematous dermatitis
  • abnormal blistering of the skin
  • erythema
  • acantholysis
  • skin vesicle
  • skin erosion

HPO human phenotypes related to Pemphigus Foliaceus:

id Description Frequency HPO Source Accession
1 acantholysis hallmark (90%) HP:0100792

Drugs & Therapeutics for Pemphigus Foliaceus

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Autoimmune Blistering Diseases StudyRecruitingNCT02753777

Search NIH Clinical Center for Pemphigus Foliaceus

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Pemphigus Foliaceus cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pemphigus Foliaceus:
Hematopoietic stem cells for pemphigus

Genetic Tests for Pemphigus Foliaceus

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Anatomical Context for Pemphigus Foliaceus

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MalaCards organs/tissues related to Pemphigus Foliaceus:

34
Skin, Neutrophil, T cells, Testes, B cells, Prostate, Thyroid

Animal Models for Pemphigus Foliaceus or affiliated genes

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MGI Mouse Phenotypes related to Pemphigus Foliaceus:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107717.6CTLA4, IL1A, IL1B, IL1RN, IL4R

Publications for Pemphigus Foliaceus

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Articles related to Pemphigus Foliaceus:

(show top 50)    (show all 551)
idTitleAuthorsYear
1
Overlapping IgG4 Responses to Self- and Environmental Antigens in Endemic Pemphigus Foliaceus. (26826247)
2016
2
Coexistence of pemphigus foliaceus and acquired hemophilia A: A case report. (25855134)
2015
3
Presence of autoimmune regulator and absence of desmoglein 1 in thymoma associated with a pemphigus foliaceus patient. (25523433)
2014
4
Locations of acantholysis in pemphigus vulgaris and pemphigus foliaceus. (25265985)
2014
5
Both qualitative and quantitative genetic variation of MHC class II molecules may influence susceptibility to autoimmune diseases: the case of endemic pemphigus foliaceus. (23777927)
2013
6
Direct immunofluorescence of the outer root sheath in anagen and telogen hair in pemphigus vulgaris and pemphigus foliaceus. (23713982)
2013
7
Localized Pemphigus Foliaceus with Unilateral Facial Involvement. (23706271)
2013
8
Cytokine gene polymorphisms in Tunisian endemic pemphigus foliaceus: a possible role of il-4 variants. (23376457)
2013
9
Pemphigus foliaceus clearance status postmyomectomy for an enlarged infarcted subserous uterine fibroid. (22583728)
2012
10
Neuromyelitis optica in a patient with pemphigus foliaceus. (22632778)
2012
11
Metaflumizone-amitraz (Promeris)-associated pustular acantholytic dermatitis in 22 dogs: evidence suggests contact drug-triggered pemphigus foliaceus. (21418349)
2011
12
Pemphigus foliaceus in a juvenile Cashmere goat, and outcome after prednisolone and methylprednisolone therapy. (22654142)
2011
13
IgE, IgM, and IgG4 anti-desmoglein 1 autoantibody profile in endemic pemphigus foliaceus (fogo selvagem). (21191415)
2011
14
Evidence-based treatments for pemphigus vulgaris, pemphigus foliaceus, and bullous pemphigoid: a systematic review. (21727693)
2011
15
Immune response towards the amino-terminus of desmoglein 1 prevails across different activity stages in nonendemic pemphigus foliaceus. (20163417)
2010
16
Canine pemphigus foliaceus antigen is localized within desmosomes of keratinocyte. (18976819)
2009
17
Pemphigus vulgaris and pemphigus foliaceus: similar prognosis? (17822493)
2007
18
Clinical evidence of an intermolecular epitope spreading in a patient with pemphigus foliaceus converting into bullous pemphigoid. (17310017)
2007
19
No evidence for association of the TP53 12139 and the BAX-248 polymorphisms with endemic pemphigus foliaceus (fogo selvagem). (16611260)
2006
20
Clinical and serological follow-up studies of endemic pemphigus foliaceus (fogo selvagem) in Western Parana, Brazil (2001-2002). (16882187)
2006
21
Antibodies against desmoglein 1 in healthy subjects in endemic and nonendemic areas of pemphigus foliaceus (fogo selvagem) in Peru. (16700787)
2006
22
Eyelid skin involvement in pemphigus foliaceus. (16419424)
2005
23
Review of 15 cases of pemphigus foliaceus in horses and a survey of the literature. (16244232)
2005
24
Direct immunofluorescence on uninvolved, lesional and perilesional skin in patients with endemic pemphigus foliaceus (fogo selvagem). (15567982)
2004
25
Pemphigus foliaceus with neutrophilic spongiosis evolving to an atypical pemphigus phenotype. (15583603)
2004
26
Treatment of pemphigus vulgaris and pemphigus foliaceus with mycophenolate mofetil. (12810504)
2003
27
Cutaneous neosporosis during treatment of pemphigus foliaceus in a dog. (12220024)
2002
28
Endemic Pemphigus foliaceus ("Fogo selvagem"): a series from the Northeastern region of the State of SALo Paulo, Brazil, 1973-1998. (11340476)
2001
29
Thyroid gland tumour, pemphigus foliaceus and myasthenia gravis in the daughter of a woman with myasthenia gravis. (11678876)
2001
30
Pemphigus foliaceus associated with silicosis. (10951170)
2000
31
An interesting case of pemphigus foliaceus in a dog. (10065323)
1999
32
The pathophysiological significance of nondesmoglein targets of pemphigus autoimmunity. Development of antibodies against keratinocyte cholinergic receptors in patients with pemphigus vulgaris and pemphigus foliaceus. (9722727)
1998
33
Pemphigus foliaceus. (9370909)
1997
34
Pemphigus foliaceus with typical histological and immunohistological findings in a dog. (8877989)
1996
35
Cell and humoral immunity in endemic pemphigus foliaceus. (7569637)
1995
36
Ultrastructural localisation of pemphigus vulgaris and pemphigus foliaceus antigens by indirect immunoelectron microscopy. Apropos of 7 cases]. (8526424)
1995
37
Tests of inflammatory activity in endemic pemphigus foliaceus]. (8008917)
1994
38
Structure of DSG1, the bovine desmosomal cadherin gene encoding the pemphigus foliaceus antigen. Evidence of polymorphism. (8294446)
1994
39
Pemphigus foliaceus. Use of antimalarial agents as adjuvant therapy. (1444499)
1992
40
Complement activation in Brazilian pemphigus foliaceus. (2805387)
1989
41
Pemphigus foliaceus with anti-intercellular and anti-basement membrane zone antibodies. Blocking immunofluorescence and Western immunoblotting studies. (3069506)
1988
42
Clinical, histologic, and immunopathologic comparison of pemphigus vulgaris and pemphigus foliaceus. (2978970)
1988
43
Exfoliative type juvenile pemphigus foliaceus: a case report. (3316467)
1987
44
Pemphigus foliaceus coexisting with toxic, multinodular goiter. (3771047)
1986
45
Concurrent development of pemphigus foliaceus and psoriasis. (4018981)
1985
46
Brazilian pemphigus foliaceus autoantibodies are pathogenic to BALB/c mice by passive transfer. (3905977)
1985
47
Coexistence of pemphigus foliaceus and mycosis fungoides. (3158289)
1985
48
Human autoantibodies against a desmosomal core protein in pemphigus foliaceus. (6491602)
1984
49
Brazilian pemphigus foliaceus. (7085163)
1982
50
Kaposi's sarcoma after steroid therapy for pemphigus foliaceus. Case report and short review of literature. (7333401)
1981

Variations for Pemphigus Foliaceus

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Expression for genes affiliated with Pemphigus Foliaceus

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Search GEO for disease gene expression data for Pemphigus Foliaceus.

Pathways for genes affiliated with Pemphigus Foliaceus

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Pathways related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathwaysScoreTop Affiliating Genes
19.8DSG1, HLA-DRB1
29.1IL1B, IL4R
39.0IL1A, IL1B
49.0IL1A, IL1B
59.0IL1A, IL1B
69.0IL1A, IL1B
78.7CTLA4, IL1B, IL1RN
88.7HLA-DRB1, IL1A, IL1B
9
Show member pathways
8.7HLA-DRB1, IL1A, IL1B
108.7HLA-DRB1, IL1A, IL1B
11
Show member pathways
8.6CTLA4, IL1A, IL1B
128.5IL1A, IL1B, IL1RN
13
Show member pathways
8.5IL1A, IL1B, IL1RN
148.2CTLA4, HLA-DRB1, IL1A, IL1B
158.1HLA-DRB1, IL1A, IL1B, IL4R
16
Show member pathways
7.7CTLA4, HLA-DRB1, IL1A, IL1B, IL4R

GO Terms for genes affiliated with Pemphigus Foliaceus

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Biological processes related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1fever generationGO:00016609.6IL1A, IL1B
2positive regulation of monocyte chemotactic protein-1 productionGO:00716399.6IL1A, IL1B
3ectopic germ cell programmed cell deathGO:00352349.6IL1A, IL1B
4positive regulation of interleukin-2 biosynthetic processGO:00450869.5IL1A, IL1B
5positive regulation of cell divisionGO:00517819.5IL1A, IL1B
6negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.4IL1A, IL1B
7ovulationGO:00307289.4IL1B, IL4R
8extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.3IL1A, IL1B
9positive regulation of vascular endothelial growth factor productionGO:00105759.2IL1A, IL1B
10positive regulation of interleukin-6 productionGO:00327559.0IL1A, IL1B
11positive regulation of mitotic nuclear divisionGO:00458409.0IL1A, IL1B
12immune responseGO:00069558.1CTLA4, IL1A, IL1RN, IL4R

Molecular functions related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00051499.5IL1A, IL1B
2cytokine activityGO:00051258.5IL1A, IL1B, IL1RN

Sources for Pemphigus Foliaceus

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet