PF
MCID: PMP004
MIFTS: 50

Pemphigus Foliaceus (PF) malady

Skin category

Summaries for Pemphigus Foliaceus

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Pemphigus foliaceus is an autoimmune blistering disease of the skin with characteristic lesions that are... more...

MalaCards: Pemphigus Foliaceus, also known as PF, is related to pemphigus and pemphigus vulgaris, and has symptoms including positive nikolski's sign/achantolysis An important gene associated with Pemphigus Foliaceus is DSG1 (desmoglein 1), and among its related pathways are Primary immunodeficiency and Rheumatoid arthritis. The compounds blys and mannan have been mentioned in the context of this disorder. Affiliated tissues include lymph node, lung and thyroid, and related mouse phenotypes are renal/urinary system and integument.

Aliases & Classifications for Pemphigus Foliaceus

Sources:
43NIH Rare Diseases, 45Novoseek, 49Orphanet, 31LifeMap Discovery™, 61UMLS, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

pemphigus foliaceus 43 45 49 31 61
pf 43


External Ids:

ICD10 via Orphanet26 L10.2
SNOMED-CT via Orphanet58 35154004
UMLS via Orphanet62 C0263313
ICD1025 L10.2

Related Diseases for Pemphigus Foliaceus

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pemphigus Foliaceus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 183)
idRelated DiseaseScoreTop Affiliating Genes
1pemphigus32.2EVPL, PPL, DSG4, DSG3, DST, DSG1
2pemphigus vulgaris31.6TNFSF13B, PPL, HLA-DRB1, IVL, DSG4, DSG3
3bullous pemphigoid31.1PPL, DST, EVPL
4thymoma30.7CTLA4, PPL, EVPL
5squamous cell carcinoma30.6CTLA4, PPL, IVL, DSG3, DST, DSG1
6systemic lupus erythematosus30.4TNFSF13B
7bullous impetigo30.4DSG1
8lichen planus30.4DST, DSG3, IVL
9arthritis30.4HLA-DRB1, CTLA4
10silicosis30.2DSG1
11tetanus30.2CD40, CD79A
12atopic dermatitis30.2IL4R, CD40, IVL, CTLA4
13graves' disease30.2CTLA4, HLA-DRB1, CD40, IL4R
14colorectal cancer29.9PRSS2, MASP2, CD40, IL4R, PLAUR
15paraneoplastic pemphigus10.6
16herpetiform pemphigus10.5
17pemphigus erythematosus10.5
18alopecia10.4
19superficial pemphigus10.4
20acanthosis nigricans10.3
21kaposi's sarcoma10.3
22porokeratosis10.3
23alopecia areata10.3
24pemphigus and fogo selvagem10.3
25transient acantholytic dermatosis10.3
26oral lichen planus10.3
27pulmonary fibrosis, familial10.2
28strongyloidiasis10.2
29limited scleroderma10.2
30diffuse scleroderma10.2
31neuromyelitis optica10.2
32subserous uterine fibroid10.2
33folliculitis10.2
34multinodular goiter10.2
35cellulitis10.2
36mixed connective tissue disease10.2
37usher syndrome10.2
38subacute glomerulonephritis10.2
39sheehan syndrome10.2
40diffuse alopecia areata10.2
41phenylketonuria10.2
42motor peripheral neuropathy10.2
43mycosis fungoides10.2
44allergic contact dermatitis10.2
45bipolar disorder10.2
46stomatitis10.2
47uterine fibroid10.2
48exfoliative dermatitis10.2
49mercury poisoning10.2
50guillain-barr� syndrome10.2

Graphical network of the top 20 diseases related to Pemphigus Foliaceus:



Diseases related to pemphigus foliaceus

Clinical Features for Pemphigus Foliaceus

Sources:
49Orphanet
See all sources


Symptoms:

49
  • positive nikolski's sign/achantolysis

Drugs & Therapeutics for Pemphigus Foliaceus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pemphigus Foliaceus

Drug clinical trials:

Search ClinicalTrials for Pemphigus Foliaceus

Search NIH Clinical Center for Pemphigus Foliaceus

Search CenterWatch for Pemphigus Foliaceus

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Pemphigus Foliaceus cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pemphigus Foliaceus:
Hematopoietic stem cells for pemphigus

Genetic Tests for Pemphigus Foliaceus

Anatomical Context for Pemphigus Foliaceus

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Pemphigus Foliaceus:

33
Lymph node, Lung, Thyroid, Salivary gland, Adrenal gland, Skin, Prostate, T cells, B cells

Animal Models for Pemphigus Foliaceus or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Pemphigus Foliaceus

Sources:
51PubMed
See all sources

Articles related to Pemphigus Foliaceus:

(show top 50)    (show all 508)
idTitleAuthorsYear
1
Biomarkers of oxidative stress in epidermis of Tunisian pemphigus foliaceus patients. (22738420)
2013
2
A Comparison of Pemphigus Foliaceus and Dermatitis Exfoliativa Neonatorum (RITTER), With Remarks on the A8TIOLOGY. (23752686)
2012
3
Pemphigus foliaceus in a juvenile Cashmere goat, and outcome after prednisolone and methylprednisolone therapy. (22654142)
2011
4
Diagnosis and clinical features of pemphigus foliaceus. (21605805)
2011
5
Human eyelid meibomian glands and tarsal muscle are recognized by autoantibodies from patients affected by a new variant of endemic pemphigus foliaceus in El-Bagre, Colombia, South America. (20061054)
2010
6
Polymorphisms in the 2q33 and 3q21 chromosome regions including T-cell coreceptor and ligand genes may influence susceptibility to pemphigus foliaceus. (20433886)
2010
7
In situ detection of inflammatory cytokines and apoptosis in pemphigus foliaceus patients. (19123745)
2009
8
Interventions for pemphigus vulgaris and pemphigus foliaceus. (19160272)
2009
9
A new variant of endemic pemphigus foliaceus in El-Bagre, Colombia: the Hardy-Weinberg-Castle law and linked short tandem repeats. (22666691)
2009
10
Juvenile pemphigus foliaceus associated with severe nonscarring alopecia. (19438865)
2009
11
Evaluation of sensitivity and specificity of enzyme-linked immunosorbent assay (ELISA) for detecting antidesmoglein 1 and 3 in Thai patients with pemphigus vulgaris and foliaceus. (19127786)
2008
12
A case of non-Hodgkin's lymphoma-associated pemphigus foliaceus and use of rituximab for treatment. (18720187)
2008
13
No evidence for association of the TP53 12139 and the BAX-248 polymorphisms with endemic pemphigus foliaceus (fogo selvagem). (16611260)
2006
14
Antibodies against desmoglein 1 in healthy subjects in endemic and nonendemic areas of pemphigus foliaceus (fogo selvagem) in Peru. (16700787)
2006
15
Equal efficacy of topical tacrolimus and clobetasone butyrate in pemphigus foliaceus. (17076736)
2006
16
Dermal dendritic cell number correlates with serum autoantibody titers in Brazilian pemphigus foliaceus patients. (15060700)
2004
17
Environmental risk factors in endemic pemphigus foliaceus (fogo selvagem). (14870983)
2004
18
Pemphigus foliaceus localized to the nose. (12950358)
2003
19
A case of co-incident phenylketonuria, pemphigus foliaceus, and tinea amiantacea treated with tetracycline and nicotinamide. (12852375)
2003
20
230-kDa and 190-kDa proteins in addition to desmoglein 1 as immunological targets in a subset of pemphigus foliaceus with a combined cell-surface and basement membrane zone immune staining pattern. (14705806)
2003
21
Tunisian endemic pemphigus foliaceus is associated with desmoglein 1 gene polymorphism. (12209366)
2002
22
Exacerbation of pemphigus foliaceus after tetanus vaccination accompanied by synthesis of auto-antibodies against paraneoplastic pemphigus antigens. (12575868)
2002
23
Treatment of pemphigus vulgaris and pemphigus foliaceus: experience with 71 patients over a 20 year period. (11246281)
2001
24
HLA class II polymorphism contributes to specify desmoglein derived peptides in pemphigus vulgaris and pemphigus foliaceus. (10936030)
2000
25
Pemphigus foliaceus and renal cell carcinoma. (10349542)
1999
26
Pemphigus foliaceus associated with cilazapril. (9602237)
1998
27
Development of pemphigus foliaceus in a patient with psoriasis: a simple coincidence? (9649683)
1998
28
Pemphigus foliaceus and oral lichen planus in a patient with systemic lupus erythematosus and thymoma. (9894364)
1998
29
Mechanisms of acantholysis in pemphigus foliaceus. (9325073)
1997
30
Curvicircular intracytoplasmic membranous structures in keratinocytes of pemphigus foliaceus. (9001981)
1996
31
Pemphigus herpetiformis is a rare clinical expression of nonendemic pemphigus foliaceus, fogo selvagem, and pemphigus vulgaris. Cooperative Group on Fogo Selvagem Research. (8543693)
1996
32
Effect of substrate on indirect immunofluorescence test for canine pemphigus foliaceus. (8740707)
1996
33
A case of localized pemphigus foliaceus. (9037922)
1996
34
Pemphigoid and pemphigus foliaceus successfully treated with topical corticosteroids. (8973033)
1996
35
Purification of immunoprecipitated pemphigus foliaceus antigen fragment and its use in radioimmunoassay. (1281865)
1992
36
Environmental risk factors in endemic pemphigus foliaceus (Fogo selvagem). "The Cooperative Group on Fogo Selvagem Research". (1593148)
1992
37
cDNA cloning of a novel human ubiquitin carrier protein. An antigenic domain specifically recognized by endemic pemphigus foliaceus autoantibodies is encoded in a secondary reading frame of this human epidermal transcript. (1379239)
1992
38
Characterization of pemphigus foliaceus antigen from human epidermis. (2045669)
1991
39
Immunoblot analyses of Brazilian pemphigus foliaceus antigen using different antigen sources. (1693841)
1990
40
Complement activation in Brazilian pemphigus foliaceus. (2805387)
1989
41
Maternal pemphigus foliaceus with cell surface antibody bound in neonatal epidermis. (3337542)
1988
42
Pemphigus foliaceus coexisting with toxic, multinodular goiter. (3771047)
1986
43
Concurrent development of pemphigus foliaceus and psoriasis. (4018981)
1985
44
Pemphigus foliaceus in dogs: a review of 37 cases. (3880732)
1985
45
An unusual association of subacute sclerosing glomerulonephritis, pemphigus foliaceus and infiltration of the deep corneal layers. (3842958)
1985
46
Transient acantholytic dermatosis associated with pemphigus foliaceus. Coexistence of two acantholytic diseases. (6337563)
1983
47
Childhood pemphigus foliaceus. Report of a case. (6990872)
1980
48
South American pemphigus foliaceus: electron microscopy and immunoelectron localization of bound immunoglobulin in the skin and oral mucosa. (6992843)
1980
49
Pemphigus foliaceus resembling eruptive seborrheic keratoses. (7396547)
1980
50
Nosology of Brazilian pemphigus foliaceus. (393642)
1979

Genetic Variations for Pemphigus Foliaceus

Expression for genes affiliated with Pemphigus Foliaceus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pemphigus Foliaceus

Search GEO for disease gene expression data for Pemphigus Foliaceus.

Pathways for genes affiliated with Pemphigus Foliaceus

Sources:
30KEGG, 54Reactome, 12EMD Millipore, 38NCBI BioSystems Database, 52QIAGEN
See all sources

Pathways related to Pemphigus Foliaceus according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3CD79A, CD19
210.2TNFSF13B, CTLA4
3
Hide members
10.2MBL2, MASP2
410.2DSG2, DSG1, DSG3
5
Hide members
10.2DSG3, DSG1, DSG2
610.2EVPL, DST, PPL
710.1HLA-DRB1, CD19, IL4R
8
Hide members
10.1CD19, CD40, MASP2
9
Hide members
10.1PLAUR, MASP2, MBL2
1010.0MBL2, HLA-DRB1, DSG1, MASP2
11
Hide members
10.0IL4R, CD79A, CD19, HLA-DRB1
12
Hide members
9.9TNFSF13B, CTLA4, HLA-DRB1, CD40, IL4R
13
Hide members
9.4CD79A, UBE2S, MBL2, CTLA4, HLA-DRB1, PRSS2

Compounds for genes affiliated with Pemphigus Foliaceus

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Pemphigus Foliaceus according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1blys4510.5CD79A, CD40, TNFSF13B
2mannan4510.5CD79A, MASP2, MBL2
3con a4510.5MBL2, CTLA4, CD79A
4pimonidazole4510.5IVL, PLAUR
5toxin a4510.5DSG3, DSG1
6mycophenolate mofetil45 50 1112.5CD79A, CD40, CTLA4
7ivig4510.4DSG3, DSG1, CD40, CD79A
8bcma4510.4CD40, TNFSF13B
9neopterin4510.4MBL2, CD40, CD79A, PLAUR
10il 104510.4IL4R, CD40, CTLA4
11p0034510.4IL4R
12suramin45 29 1112.4IVL, PLAUR
13rantes4510.4IL4R, CD40, MBL2
14mannose4510.3MBL2, MASP2, CD40, CD79A
15prednisolone45 29 1112.3MBL2, DSG3, CD40, CD79A
16rituximab45 50 1112.3TNFSF13B, CTLA4, DSG1, CD40, CD79A
17serine4510.3CTLA4, IVL, DSG3, DSG1, MASP2
18methotrexate45 50 1112.3CTLA4, HLA-DRB1, IVL, CD40, CD79A
19fibrinogen4510.3MBL2, MASP2, CD40, CD79A, PLAUR
20vitamin d4510.2MBL2, CTLA4, IVL, CD79A, PLAUR
2112-o-tetradecanoylphorbol 13-acetate4510.2PLAUR, CD40, DST, IVL
22paraffin4510.2MBL2, IVL, DST, CD40, CD79A, PLAUR
23creatinine4510.2MBL2, TNFSF13B, CD40, CD79A, PLAUR
24acetylcholine45 50 29 11 2414.2CD79A, DSG1, DSG3, CTLA4
25cyclosporin a45 29 6012.2CTLA4, IVL, CD40, CD79A, IL4R
26allergens4510.2CTLA4, HLA-DRB1, IVL, CD40, CD79A, IL4R
27biotin45 11 2412.2CD40, CD79A, PLAUR
28tuberculin4510.1CD79A, MBL2
29alanine4510.1TNFSF13B, CTLA4, HLA-DRB1, MASP2, CD79A, PLAUR
30thymidine45 2411.1TNFSF13B, CTLA4, IVL, CD40, IL4R, PLAUR
31phosphatidylinositol4510.0CTLA4, IVL, CD40, CD19, IL4R, PLAUR
32steroid4510.0MBL2, CTLA4, IVL, CD40, CD79A, IL4R
33dexamethasone45 50 29 1113.0MBL2, CTLA4, IVL, CD40, CD79A, IL4R
34cysteine4510.0MBL2, CTLA4, PRSS2, IVL, CD40, CD79A
35cholesterol45 29 11 2413.0MBL2, CTLA4, IVL, CD40, PLAUR
36glatiramer acetate45 1111.0HLA-DRB1, CTLA4
37oligonucleotide459.9IVL, DST, CD40, PLAUR, HLA-DRB1
38lipid459.9MBL2, CTLA4, PPL, IVL, CD40, CD19
39tyrosine459.7MBL2, CTLA4, HLA-DRB1, IVL, DSG3, DSG2
40calcium45 50 11 2412.2PLAUR, MBL2, TNFSF13B, CTLA4, PRSS2, IVL

GO Terms for genes affiliated with Pemphigus Foliaceus

Sources:
16Gene Ontology
See all sources

Cellular components related to Pemphigus Foliaceus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.8CTLA4, HLA-DRB1, CD40, CD19, CD79A
2desmosomeGO:0300579.8EVPL, DSG2, DSG1, DSG3, DSG4, PPL
3integral to plasma membraneGO:0058879.8HLA-DRB1, CD40, CD19, IL4R, PLAUR, CTLA4
4plasma membraneGO:0058868.8TNFSF13B, CTLA4, PPL, HLA-DRB1, DSG4, DSG3

Biological processes related to Pemphigus Foliaceus according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1B cell receptor signaling pathwayGO:05085310.4CD79A, CD19, CTLA4
2cellular component disassembly involved in execution phase of apoptosisGO:00692110.3DSG2, DSG1, DSG3
3keratinizationGO:03142410.2PPL, IVL, EVPL
4complement activation, lectin pathwayGO:00186710.2MASP2, MBL2
5homophilic cell adhesionGO:00715610.2DSG2, DSG1, DSG3, DSG4
6keratinocyte differentiationGO:03021610.2IVL, DSG4, EVPL
7T cell costimulationGO:03129510.0HLA-DRB1, CTLA4, TNFSF13B
8immune responseGO:00695510.0IL4R, HLA-DRB1, CTLA4, TNFSF13B
9B cell proliferationGO:04210010.0CD40, CD79A

Molecular functions related to Pemphigus Foliaceus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium ion bindingGO:0055099.7MASP2, DSG2, DSG1, DST, DSG3, DSG4

Products for genes affiliated with Pemphigus Foliaceus

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pemphigus Foliaceus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet