PF
MCID: PMP004
MIFTS: 42

Pemphigus Foliaceus (PF) malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Pemphigus Foliaceus

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Sources:
30ICD10, 31ICD10 via Orphanet, 35LifeMap Discovery®, 48NIH Rare Diseases, 50Novoseek, 54Orphanet, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Pemphigus Foliaceus:

Name: Pemphigus Foliaceus 35 48 54 50 68
 
Pf 48

Classifications:

Orphanet: 54 
Rare skin diseases


External Ids:

Orphanet54 ORPHA79481
UMLS via Orphanet69 C0263313
ICD10 via Orphanet31 L10.2
ICD1030 L10.2

Summaries for Pemphigus Foliaceus

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Wikipedia:71 Pemphigus foliaceus is an autoimmune blistering disease of the skin with characteristic lesions that are... more...

MalaCards based summary: Pemphigus Foliaceus, also known as PF, is related to pemphigus and pemphigus erythematosus, and has symptoms including Array, Array and Array. An important gene associated with Pemphigus Foliaceus is DSG1 (Desmoglein 1), and among its related pathways are Staphylococcus aureus infection and Apoptotic cleavage of cellular proteins. Affiliated tissues include skin, neutrophil and t cells.

Related Diseases for Pemphigus Foliaceus

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Diseases related to Pemphigus Foliaceus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1pemphigus11.8
2pemphigus erythematosus11.4
3pemphigus and fogo selvagem11.2
4pemphigus vulgaris10.7
5herpetiform pemphigus10.6
6bullous pemphigoid10.3
7psoriasis10.2
8immunodeficiency by defective expression of hla class 110.2DSG1, DSG3
9x-linked intellectual disability-epilepsy-progressive joint contractures-dysmorphism syndrome10.2DSG1, PPL
10myasthenia gravis10.2
11dermatitis10.2
12paraneoplastic pemphigus10.2
13esophagus carcinoma in situ10.1DSG1, DSG2
14peptidic growth factors deficiency10.1DST, HLA-DRB1
15subglottis neoplasm10.1DSG1, DSG3
16thymoma10.1
17oral cavity cancer10.0DSG1, DST
18articulation disorder10.0DSG1, DSG3, HLA-DRB1
19cardiomyopathy, dilated, 1bb10.0DSG1, DSP
20pneumonia caused by pseudomonas aeruginosa infection10.0DSG1, DSP
21x-linked intellectual disability-precocious puberty-obesity syndrome10.0DSG3, DSP
22myalgia-eosinophilia syndrome associated with tryptophan10.0DSG1, DSG3, DST
23mucositis10.0
24solitary bone cyst10.0DSG1, DSG3, DST
25pharc syndrome10.0DSG1, DSG3
26ovarian mucinous malignant adenofibroma10.0DSG1, DSP
27rheumatoid arthritis10.0
28systemic lupus erythematosus10.0
29alopecia10.0
30arthritis10.0
31lymphoma10.0
32lupus erythematosus10.0
33lipoma9.9DSG1, DSP
34fibular hemimelia, bilateral9.9DSG2, DSP
35fibular hemimelia, unilateral9.9DSG2, DSP
36congenital absence of upper arm and forearm with hand present, bilateral9.9DSG2, DSP
37mosaic trisomy 19.9DSG2, DSP
38retinitis pigmentosa 189.9DSG2, DSP
39carotid artery thrombosis9.9DSG1, DSP
40hepatitis9.9
41dermatomyositis9.9
42sarcoma9.9
43graves' disease9.9
44prostatitis9.9
45squamous cell carcinoma9.9
46acanthosis nigricans9.9
47porokeratosis9.9
48thyroiditis9.9
49impetigo9.9
50lichen planus9.9

Graphical network of the top 20 diseases related to Pemphigus Foliaceus:



Diseases related to pemphigus foliaceus

Symptoms & Phenotypes for Pemphigus Foliaceus

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Human phenotypes related to Pemphigus Foliaceus:

 54 64 (show all 6)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 crusting erythematous dermatitis64 54 Very frequent (99-80%) HP:0007473
2 abnormal blistering of the skin64 54 Very frequent (99-80%) HP:0008066
3 erythema64 54 Very frequent (99-80%) HP:0010783
4 acantholysis64 54 Very frequent (99-80%) HP:0100792
5 skin vesicle64 54 Very frequent (99-80%) HP:0200037
6 skin erosion64 54 Very frequent (99-80%) HP:0200041

Drugs & Therapeutics for Pemphigus Foliaceus

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Interventional clinical trials:

idNameStatusNCT IDPhase
1A Safety Study of SYNT001 in Subjects With Pemphigus (Vulgaris or Foliaceus)Not yet recruitingNCT03075904Phase 1
2Autoimmune Blistering Diseases StudyRecruitingNCT02753777
3Serum IL-21 Levels in Patients With Pemphigus VulgarisNot yet recruitingNCT03177213

Search NIH Clinical Center for Pemphigus Foliaceus

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Pemphigus Foliaceus cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pemphigus Foliaceus:
Hematopoietic stem cells for pemphigus

Genetic Tests for Pemphigus Foliaceus

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Anatomical Context for Pemphigus Foliaceus

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MalaCards organs/tissues related to Pemphigus Foliaceus:

36
Skin, Neutrophil, T cells, Testes, B cells, Prostate, Thyroid

Publications for Pemphigus Foliaceus

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Articles related to Pemphigus Foliaceus:

(show top 50)    (show all 553)
idTitleAuthorsYear
1
Concurrent Pemphigus Foliaceus and Graves' Disease. (27981628)
2016
2
Differential HLA class I and class II associations in pemphigus foliaceus and pemphigus vulgaris patients from a prevalent Southeastern Brazilian region. (27178774)
2016
3
Non-drug-induced pemphigus foliaceus in a patient with rheumatoid arthritis. (27023089)
2016
4
A 3'UTR polymorphism marks differential KLRG1 mRNA levels through disruption of a miR-584-5p binding site and associates with pemphigus foliaceus susceptibility. (27424220)
2016
5
Systemic lupus erythematosus associated with myasthenia gravis, pemphigus foliaceus and chronic thyroiditis after thymectomy. (27270472)
2016
6
Patients with pemphigus foliaceus may retain antibody reactivity against calcium-stabilized, distal desmoglein 1 domains in remission. (26790650)
2016
7
Infektionsassoziiertes gemeinsames Auftreten von Psoriasis pustulosa, Pemphigus foliaceus und leukozyoklastischer Vaskulitis. (27509422)
2016
8
Childhood Pemphigus Foliaceus with Exclusive Immunoglobulin G Autoantibodies to Desmocollins. (26758100)
2016
9
Pemphigus foliaceus with circinated plaques and neutrophil pustules. (27514363)
2016
10
Pemphigus foliaceus induced by topical 5-fluorouracil. (26879697)
2016
11
Pemphigus foliaceus associated with Hypericum perforatum. (27579342)
2016
12
Non-pathogenic pemphigus foliaceus (PF) IgG acts synergistically with a directly pathogenic PF IgG to increase blistering by p38MAPK-dependent desmoglein 1 clustering. (28024684)
2016
13
Overlapping IgG4 Responses to Self- and Environmental Antigens in Endemic Pemphigus Foliaceus. (26826247)
2016
14
Pemphigus foliaceus exacerbated by radiation, in association with myasthenia gravis. (27136623)
2016
15
Coincidence of annular pustular psoriasis, pemphigus foliaceus, and leukocytoclastic vasculitis associated with chronic cholecystitis. (27509423)
2016
16
Increased serum levels of vascular endothelial growth factor in pemphigus foliaceus patients with erythroderma. (27510449)
2016
17
Prediction of survival for patients with pemphigus vulgaris and pemphigus foliaceus: a retrospective cohort study. (25896794)
2015
18
Evaluation of blood and urinary mercury in pemphigus vulgaris and pemphigus foliaceus patients and its comparison with control group. (25751363)
2015
19
Diaminodiphenyl sulfone-induced eosinophilic pneumonia in a patient with pemphigus foliaceus. (26055208)
2015
20
A case of pemphigus foliaceus aggravated in an irradiated area by radiotherapy against breast cancer. (25657410)
2015
21
Pemphigus Foliaceus Complicated by Kaposi Varicelliform Eruption. (26724884)
2015
22
Update on fogo selvagem, an endemic form of pemphigus foliaceus. (25558948)
2015
23
Coexistence of pemphigus foliaceus and acquired hemophilia A: A case report. (25855134)
2015
24
CTLA4 overexpressing adipose tissue-derived mesenchymal stem cell therapy in a dog with steroid-refractory pemphigus foliaceus. (25889154)
2015
25
Epitope analysis of antidesmoglein 1 autoantibodies from patients with pemphigus foliaceus across different activity stages. (26294113)
2015
26
Canine pemphigus foliaceus with concurrent immune-mediated thrombocytopenia. (25415212)
2015
27
Oral glucocorticoid pulse therapy for induction of treatment of canine pemphigus foliaceus - a comparative study. (26248494)
2015
28
Pemphigus foliaceus occurring with adenocarcinoma of prostate. (26261142)
2015
29
Is there any relationship between polymorphism of Heat Shock Protein 70 genes and Pemphigus foliaceus? (25687737)
2015
30
Treatment of pemphigus vulgaris and pemphigus foliaceus: a systematic review and meta-analysis. (25403548)
2014
31
Demodicidosis on the arms of a patient with pemphigus foliaceus. (25128143)
2014
32
Rapid transition from pemphigus vulgaris to pemphigus foliaceus. (25376758)
2014
33
Antibodies to the amino-terminal domain of desmoglein 1 are retained during transition from pemphigus vulgaris to pemphigus foliaceus. (24776707)
2014
34
Presence of autoimmune regulator and absence of desmoglein 1 in thymoma associated with a pemphigus foliaceus patient. (25523433)
2014
35
Localized pemphigus foliaceus with unilateral facial involvement. (24784930)
2014
36
Locations of acantholysis in pemphigus vulgaris and pemphigus foliaceus. (25265985)
2014
37
The value of trichoscopy in the differential diagnosis of scalp lesions in pemphigus vulgaris and pemphigus foliaceus. (25387515)
2014
38
Rituximab therapy in pemphigus foliaceus: report of 12 cases and review of recent literature. (25496559)
2014
39
A rare case of annular pustular psoriasis associated with pemphigus foliaceus. (24882987)
2014
40
Evaluation of cases of pemphigus vulgaris and pemphigus foliaceus from a reference service in ParA! state, Brazil. (25054740)
2014
41
Fipronil-amitraz-S-methoprene-triggered pemphigus foliaceus in 21 dogs: clinical, histological and immunological characteristics. (24666660)
2014
42
Genome-wide gene expression profiling reveals unsuspected molecular alterations in pemphigus foliaceus. (24813052)
2014
43
A blistering response: concurrent psoriasis and pemphigus foliaceus. (25239159)
2014
44
Mycophenolate mofetil and enteric-coated mycophenolate sodium in the treatment of pemphigus vulgaris and pemphigus foliaceus. (24521072)
2014
45
Pemphigus foliaceus. (25526343)
2014
46
JID VisualDx Quiz: August 2014: pemphigus foliaceus. (25029324)
2014
47
Serum autoantibody profiles of IgA, IgE and IgM in canine pemphigus foliaceus. (24975693)
2014
48
Exacerbation of Pemphigus Foliaceus After Electron-beam Radiation. (24626406)
2014
49
A patient with pemphigus foliaceus and myasthenia gravis treated by a cortisol-secreting adrenal adenoma. (24931108)
2014
50
Pemphigus Foliaceus in an Adolescent. (25151193)
2014

Variations for Pemphigus Foliaceus

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Expression for genes affiliated with Pemphigus Foliaceus

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Search GEO for disease gene expression data for Pemphigus Foliaceus.

Pathways for genes affiliated with Pemphigus Foliaceus

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GO Terms for genes affiliated with Pemphigus Foliaceus

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Cellular components related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lateral plasma membraneGO:001632810.4DSG1, DSG2
2ficolin-1-rich granule membraneGO:010100310.1DSG1, DSP
3intercalated discGO:00147049.9DSG2, DSP
4cell-cell junctionGO:00059119.6DSG1, DSG2, DSP
5cytoskeletonGO:00058569.1DSP, DST, EVPL, PPL
6cornified envelopeGO:00015338.1DSG1, DSG2, DSG3, DSP, EVPL, PPL
7desmosomeGO:00300578.1DSG1, DSG2, DSG3, DSP, EVPL, PPL
8cell junctionGO:00300547.7DSG1, DSG2, DSG3, DSP, DST, EVPL
9extracellular exosomeGO:00700627.2DSG1, DSG2, DSG3, DSP, DST, EVPL
10plasma membraneGO:00058867.0DSG1, DSG2, DSG3, DSP, DST, HLA-DRB1

Biological processes related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1maternal process involved in female pregnancyGO:006013510.2DSG1, DSG2
2intermediate filament cytoskeleton organizationGO:00451049.9DSP, DST
3bundle of His cell-Purkinje myocyte adhesion involved in cell communicationGO:00860739.8DSG2, DSP
4desmosome organizationGO:00029349.8DSG2, DSP
5homophilic cell adhesion via plasma membrane adhesion moleculesGO:00071569.7DSG1, DSG2, DSG3
6response to progesteroneGO:00325709.6DSG1, DSG2
7keratinocyte differentiationGO:00302169.6DSP, EVPL
8regulation of heart rate by cardiac conductionGO:00860919.6DSG2, DSP
9regulation of ventricular cardiac muscle cell action potentialGO:00989119.6DSG2, DSP
10peptide cross-linkingGO:00181499.5DSP, EVPL
11cell adhesionGO:00071559.4DSG1, DSG2, DSG3, DST
12cornificationGO:00702687.9DSG1, DSG2, DSG3, DSP, EVPL, PPL
13keratinizationGO:00314247.9DSG1, DSG2, DSG3, DSP, EVPL, PPL

Molecular functions related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell adhesion molecule bindingGO:00508399.6DSG2, DSP
2cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communicationGO:00860839.6DSG2, DSP
3calcium ion bindingGO:00055099.2DSG1, DSG2, DSG3, DST
4protein binding, bridgingGO:00306749.0DSP, EVPL

Sources for Pemphigus Foliaceus

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet