MCID: PMP004
MIFTS: 39

Pemphigus Foliaceus malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Pemphigus Foliaceus

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Sources:
29ICD10, 30ICD10 via Orphanet, 34LifeMap Discovery®, 47NIH Rare Diseases, 49Novoseek, 53Orphanet, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Pemphigus Foliaceus:

Name: Pemphigus Foliaceus 34 47 53 49 67
 
Pf 47

Classifications:

Orphanet: 53 
Rare skin diseases


External Ids:

Orphanet53 ORPHA79481
UMLS via Orphanet68 C0263313
ICD10 via Orphanet30 L10.2
ICD1029 L10.2

Summaries for Pemphigus Foliaceus

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Wikipedia:70 Pemphigus foliaceus is an autoimmune blistering disease of the skin with characteristic lesions that are... more...

MalaCards based summary: Pemphigus Foliaceus, also known as pf, is related to impetigo and usher syndrome, and has symptoms including acantholysis, Array and Array. An important gene associated with Pemphigus Foliaceus is DSG1 (Desmoglein 1), and among its related pathways are Staphylococcus aureus infection and Alpha6-Beta4 Integrin Signaling Pathway. Affiliated tissues include skin, neutrophil and t cells.

Related Diseases for Pemphigus Foliaceus

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Diseases related to Pemphigus Foliaceus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1impetigo29.1DSG1, DSP, DST
2usher syndrome28.9DSG2, DSP
3pemphigus and fogo selvagem11.2
4pemphigus11.1
5pemphigus vulgaris10.7
6herpetiform pemphigus10.6
7meningococcal meningitis10.3DSG1, DSG3
8bullous pemphigoid10.3
9psoriasis10.2
10skin amelanotic melanoma10.2DSG1, DSG3
11myasthenia gravis10.2
12dermatitis10.2
13paraneoplastic pemphigus10.2
14giant ganglionic hyperplasia10.1DST, HLA-DRB1
15malignant histiocytosis10.1DSG1, DST
16thymoma10.1
17lipomatosis10.0DSG1, DSG2
18acute poisoning by drugs with membrane-stabilizing effect10.0DSG1, DSP
19cardiomyopathy, dilated, 1bb10.0DSG1, DSP
20rheumatoid arthritis10.0
21systemic lupus erythematosus10.0
22alopecia10.0
23arthritis10.0
24lymphoma10.0
25lupus erythematosus10.0
26sacrococcygeal dysgenesis association9.9DSG1, DSG3, DST
27peri-anal fistula9.9DSG1, DST, HLA-DRB1
28gastric cardia carcinoma9.9DSG1, DSP
29hepatitis9.9
30dermatomyositis9.9
31sarcoma9.9
32graves' disease9.9
33prostatitis9.9
34acanthosis nigricans9.9
35porokeratosis9.9
36thyroiditis9.9
37lichen planus9.9
38alopecia areata9.9
39oral lichen planus9.9
40pustular psoriasis9.9
41bullous impetigo9.9
42laryngeal disease9.9DSG1, DSP
43frontotemporal dementia, right temporal atrophy variant9.8DSG2, DSP
44fixed pigmented erythema9.8DSG2, DSP
45ketamine-induced biliary dilatation9.8DSG2, DSP
46atrial standstill, digenic9.7DSG2, DSP
47hiv-19.7
48prostate cancer9.7
49hepatocellular carcinoma9.7
50breast cancer9.7

Graphical network of the top 20 diseases related to Pemphigus Foliaceus:



Diseases related to pemphigus foliaceus

Symptoms for Pemphigus Foliaceus

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Human phenotypes related to Pemphigus Foliaceus:

 63 53 (show all 6)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 acantholysis63 53 hallmark (90%) Very frequent (99-80%) HP:0100792
2 crusting erythematous dermatitis53 Very frequent (99-80%)
3 abnormal blistering of the skin53 Very frequent (99-80%)
4 erythema53 Very frequent (99-80%)
5 skin vesicle53 Very frequent (99-80%)
6 skin erosion53 Very frequent (99-80%)

Drugs & Therapeutics for Pemphigus Foliaceus

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Autoimmune Blistering Diseases StudyRecruitingNCT02753777

Search NIH Clinical Center for Pemphigus Foliaceus

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Pemphigus Foliaceus cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pemphigus Foliaceus:
Hematopoietic stem cells for pemphigus

Genetic Tests for Pemphigus Foliaceus

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Anatomical Context for Pemphigus Foliaceus

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MalaCards organs/tissues related to Pemphigus Foliaceus:

35
Skin, Neutrophil, T cells, Testes, B cells, Prostate, Thyroid

Animal Models for Pemphigus Foliaceus or affiliated genes

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Publications for Pemphigus Foliaceus

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Articles related to Pemphigus Foliaceus:

(show top 50)    (show all 553)
idTitleAuthorsYear
1
Overlapping IgG4 Responses to Self- and Environmental Antigens in Endemic Pemphigus Foliaceus. (26826247)
2016
2
Coexistence of pemphigus foliaceus and acquired hemophilia A: A case report. (25855134)
2015
3
Presence of autoimmune regulator and absence of desmoglein 1 in thymoma associated with a pemphigus foliaceus patient. (25523433)
2014
4
Locations of acantholysis in pemphigus vulgaris and pemphigus foliaceus. (25265985)
2014
5
Both qualitative and quantitative genetic variation of MHC class II molecules may influence susceptibility to autoimmune diseases: the case of endemic pemphigus foliaceus. (23777927)
2013
6
Direct immunofluorescence of the outer root sheath in anagen and telogen hair in pemphigus vulgaris and pemphigus foliaceus. (23713982)
2013
7
Localized Pemphigus Foliaceus with Unilateral Facial Involvement. (23706271)
2013
8
Cytokine gene polymorphisms in Tunisian endemic pemphigus foliaceus: a possible role of il-4 variants. (23376457)
2013
9
Pemphigus foliaceus clearance status postmyomectomy for an enlarged infarcted subserous uterine fibroid. (22583728)
2012
10
Neuromyelitis optica in a patient with pemphigus foliaceus. (22632778)
2012
11
Metaflumizone-amitraz (Promeris)-associated pustular acantholytic dermatitis in 22 dogs: evidence suggests contact drug-triggered pemphigus foliaceus. (21418349)
2011
12
Pemphigus foliaceus in a juvenile Cashmere goat, and outcome after prednisolone and methylprednisolone therapy. (22654142)
2011
13
IgE, IgM, and IgG4 anti-desmoglein 1 autoantibody profile in endemic pemphigus foliaceus (fogo selvagem). (21191415)
2011
14
Evidence-based treatments for pemphigus vulgaris, pemphigus foliaceus, and bullous pemphigoid: a systematic review. (21727693)
2011
15
Immune response towards the amino-terminus of desmoglein 1 prevails across different activity stages in nonendemic pemphigus foliaceus. (20163417)
2010
16
Canine pemphigus foliaceus antigen is localized within desmosomes of keratinocyte. (18976819)
2009
17
Pemphigus vulgaris and pemphigus foliaceus: similar prognosis? (17822493)
2007
18
Clinical evidence of an intermolecular epitope spreading in a patient with pemphigus foliaceus converting into bullous pemphigoid. (17310017)
2007
19
No evidence for association of the TP53 12139 and the BAX-248 polymorphisms with endemic pemphigus foliaceus (fogo selvagem). (16611260)
2006
20
Clinical and serological follow-up studies of endemic pemphigus foliaceus (fogo selvagem) in Western Parana, Brazil (2001-2002). (16882187)
2006
21
Antibodies against desmoglein 1 in healthy subjects in endemic and nonendemic areas of pemphigus foliaceus (fogo selvagem) in Peru. (16700787)
2006
22
Eyelid skin involvement in pemphigus foliaceus. (16419424)
2005
23
Review of 15 cases of pemphigus foliaceus in horses and a survey of the literature. (16244232)
2005
24
Direct immunofluorescence on uninvolved, lesional and perilesional skin in patients with endemic pemphigus foliaceus (fogo selvagem). (15567982)
2004
25
Pemphigus foliaceus with neutrophilic spongiosis evolving to an atypical pemphigus phenotype. (15583603)
2004
26
Treatment of pemphigus vulgaris and pemphigus foliaceus with mycophenolate mofetil. (12810504)
2003
27
Cutaneous neosporosis during treatment of pemphigus foliaceus in a dog. (12220024)
2002
28
Endemic Pemphigus foliaceus ("Fogo selvagem"): a series from the Northeastern region of the State of SALo Paulo, Brazil, 1973-1998. (11340476)
2001
29
Thyroid gland tumour, pemphigus foliaceus and myasthenia gravis in the daughter of a woman with myasthenia gravis. (11678876)
2001
30
Pemphigus foliaceus associated with silicosis. (10951170)
2000
31
An interesting case of pemphigus foliaceus in a dog. (10065323)
1999
32
The pathophysiological significance of nondesmoglein targets of pemphigus autoimmunity. Development of antibodies against keratinocyte cholinergic receptors in patients with pemphigus vulgaris and pemphigus foliaceus. (9722727)
1998
33
Pemphigus foliaceus. (9370909)
1997
34
Pemphigus foliaceus with typical histological and immunohistological findings in a dog. (8877989)
1996
35
Cell and humoral immunity in endemic pemphigus foliaceus. (7569637)
1995
36
Ultrastructural localisation of pemphigus vulgaris and pemphigus foliaceus antigens by indirect immunoelectron microscopy. Apropos of 7 cases]. (8526424)
1995
37
Tests of inflammatory activity in endemic pemphigus foliaceus]. (8008917)
1994
38
Structure of DSG1, the bovine desmosomal cadherin gene encoding the pemphigus foliaceus antigen. Evidence of polymorphism. (8294446)
1994
39
Pemphigus foliaceus. Use of antimalarial agents as adjuvant therapy. (1444499)
1992
40
Complement activation in Brazilian pemphigus foliaceus. (2805387)
1989
41
Pemphigus foliaceus with anti-intercellular and anti-basement membrane zone antibodies. Blocking immunofluorescence and Western immunoblotting studies. (3069506)
1988
42
Clinical, histologic, and immunopathologic comparison of pemphigus vulgaris and pemphigus foliaceus. (2978970)
1988
43
Exfoliative type juvenile pemphigus foliaceus: a case report. (3316467)
1987
44
Pemphigus foliaceus coexisting with toxic, multinodular goiter. (3771047)
1986
45
Concurrent development of pemphigus foliaceus and psoriasis. (4018981)
1985
46
Brazilian pemphigus foliaceus autoantibodies are pathogenic to BALB/c mice by passive transfer. (3905977)
1985
47
Coexistence of pemphigus foliaceus and mycosis fungoides. (3158289)
1985
48
Human autoantibodies against a desmosomal core protein in pemphigus foliaceus. (6491602)
1984
49
Brazilian pemphigus foliaceus. (7085163)
1982
50
Kaposi's sarcoma after steroid therapy for pemphigus foliaceus. Case report and short review of literature. (7333401)
1981

Variations for Pemphigus Foliaceus

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Expression for genes affiliated with Pemphigus Foliaceus

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Search GEO for disease gene expression data for Pemphigus Foliaceus.

Pathways for genes affiliated with Pemphigus Foliaceus

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GO Terms for genes affiliated with Pemphigus Foliaceus

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Cellular components related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cornified envelopeGO:00015339.9DSP, EVPL
2lateral plasma membraneGO:00163289.3DSG1, DSG2
3cell-cell junctionGO:00059119.2DSG1, DSG2, DSP
4intercalated discGO:00147049.1DSG2, DSP
5desmosomeGO:00300576.9DSG1, DSG2, DSG3, DSP, EVPL, PPL
6extracellular exosomeGO:00700626.3DSG1, DSG2, DSG3, DSP, DST, EVPL

Biological processes related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1intermediate filament cytoskeleton organizationGO:00451049.8DSP, DST
2response to progesteroneGO:00325709.7DSG1, DSG2
3desmosome organizationGO:00029349.7DSG2, DSP
4keratinizationGO:00314249.7EVPL, PPL
5maternal process involved in female pregnancyGO:00601359.7DSG1, DSG2
6peptide cross-linkingGO:00181499.6DSP, EVPL
7keratinocyte differentiationGO:00302169.6DSP, EVPL
8epidermis developmentGO:00085449.5DSP, EVPL
9bundle of His cell-Purkinje myocyte adhesion involved in cell communicationGO:00860739.1DSG2, DSP
10regulation of heart rate by cardiac conductionGO:00860919.1DSG2, DSP
11regulation of ventricular cardiac muscle cell action potentialGO:00989118.8DSG2, DSP
12homophilic cell adhesion via plasma membrane adhesion moleculesGO:00071568.8DSG1, DSG2, DSG3

Molecular functions related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein binding, bridgingGO:00306749.7DSP, EVPL
2cell adhesion molecule bindingGO:00508399.5DSG2, DSP
3structural constituent of cytoskeletonGO:00052009.4DSP, PPL
4cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communicationGO:00860839.1DSG2, DSP
5calcium ion bindingGO:00055098.2DSG1, DSG2, DSG3, DST

Sources for Pemphigus Foliaceus

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet