PF
MCID: PMP004
MIFTS: 42

Pemphigus Foliaceus (PF) malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Pemphigus Foliaceus

Aliases & Descriptions for Pemphigus Foliaceus:

Name: Pemphigus Foliaceus 38 50 56 52 69
Pf 50

Classifications:

Orphanet: 56  
Rare skin diseases


External Ids:

Orphanet 56 ORPHA79481
UMLS via Orphanet 70 C0263313
ICD10 via Orphanet 34 L10.2
ICD10 33 L10.2

Summaries for Pemphigus Foliaceus

MalaCards based summary : Pemphigus Foliaceus, also known as pf, is related to pemphigus and pemphigus erythematosus, and has symptoms including abnormal blistering of the skin, erythema and skin vesicle. An important gene associated with Pemphigus Foliaceus is DSG1 (Desmoglein 1), and among its related pathways/superpathways are Developmental Biology and Keratinization. Affiliated tissues include skin, neutrophil and t cells.

Wikipedia : 71 Pemphigus foliaceus is an autoimmune blistering disease of the skin with characteristic lesions that are... more...

Related Diseases for Pemphigus Foliaceus

Diseases related to Pemphigus Foliaceus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
id Related Disease Score Top Affiliating Genes
1 pemphigus 11.8
2 pemphigus erythematosus 11.4
3 pemphigus and fogo selvagem 11.2
4 pemphigus vulgaris 10.7
5 herpetiform pemphigus 10.6
6 bullous pemphigoid 10.3
7 psoriasis 10.2
8 immunodeficiency by defective expression of hla class 1 10.2 DSG1 DSG3
9 x-linked intellectual disability-epilepsy-progressive joint contractures-dysmorphism syndrome 10.2 DSG1 PPL
10 dermatitis 10.2
11 myasthenia gravis 10.2
12 paraneoplastic pemphigus 10.2
13 esophagus carcinoma in situ 10.1 DSG1 DSG2
14 peptidic growth factors deficiency 10.1 DST HLA-DRB1
15 subglottis neoplasm 10.1 DSG1 DSG3
16 thymoma 10.1
17 oral cavity cancer 10.0 DSG1 DST
18 articulation disorder 10.0 DSG1 DSG3 HLA-DRB1
19 cardiomyopathy, dilated, 1bb 10.0 DSG1 DSP
20 pneumonia caused by pseudomonas aeruginosa infection 10.0 DSG1 DSP
21 x-linked intellectual disability-precocious puberty-obesity syndrome 10.0 DSG3 DSP
22 myalgia-eosinophilia syndrome associated with tryptophan 10.0 DSG1 DSG3 DST
23 mucositis 10.0
24 solitary bone cyst 10.0 DSG1 DSG3 DST
25 ovarian mucinous malignant adenofibroma 10.0 DSG1 DSP
26 pharc syndrome 10.0 DSG1 DSG3
27 alopecia 10.0
28 lymphoma 10.0
29 arthritis 10.0
30 rheumatoid arthritis 10.0
31 systemic lupus erythematosus 10.0
32 lupus erythematosus 10.0
33 lipoma 9.9 DSG1 DSP
34 fibular hemimelia, bilateral 9.9 DSG2 DSP
35 fibular hemimelia, unilateral 9.9 DSG2 DSP
36 congenital absence of upper arm and forearm with hand present, bilateral 9.9 DSG2 DSP
37 mosaic trisomy 1 9.9 DSG2 DSP
38 retinitis pigmentosa 18 9.9 DSG2 DSP
39 carotid artery thrombosis 9.9 DSG1 DSP
40 squamous cell carcinoma 9.9
41 alopecia areata 9.9
42 dermatomyositis 9.9
43 thyroiditis 9.9
44 impetigo 9.9
45 hepatitis 9.9
46 sarcoma 9.9
47 oral lichen planus 9.9
48 acanthosis nigricans 9.9
49 graves' disease 9.9
50 pustular psoriasis 9.9

Graphical network of the top 20 diseases related to Pemphigus Foliaceus:



Diseases related to Pemphigus Foliaceus

Symptoms & Phenotypes for Pemphigus Foliaceus

Human phenotypes related to Pemphigus Foliaceus:

56 32 (show all 6)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormal blistering of the skin 56 32 Very frequent (99-80%) HP:0008066
2 erythema 56 32 Very frequent (99-80%) HP:0010783
3 skin vesicle 56 32 Very frequent (99-80%) HP:0200037
4 skin erosion 56 32 Very frequent (99-80%) HP:0200041
5 acantholysis 56 32 Very frequent (99-80%) HP:0100792
6 crusting erythematous dermatitis 56 32 Very frequent (99-80%) HP:0007473

Drugs & Therapeutics for Pemphigus Foliaceus

Interventional clinical trials:


id Name Status NCT ID Phase
1 A Safety Study of SYNT001 in Subjects With Pemphigus (Vulgaris or Foliaceus) Not yet recruiting NCT03075904 Phase 1
2 Autoimmune Blistering Diseases Study Recruiting NCT02753777
3 Serum IL-21 Levels in Patients With Pemphigus Vulgaris Not yet recruiting NCT03177213

Search NIH Clinical Center for Pemphigus Foliaceus

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Pemphigus Foliaceus cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pemphigus Foliaceus:
Hematopoietic stem cells for pemphigus

Genetic Tests for Pemphigus Foliaceus

Anatomical Context for Pemphigus Foliaceus

MalaCards organs/tissues related to Pemphigus Foliaceus:

39
Skin, Neutrophil, T Cells, Testes, B Cells, Thyroid, Prostate

Publications for Pemphigus Foliaceus

Articles related to Pemphigus Foliaceus:

(show top 50) (show all 553)
id Title Authors Year
1
Concurrent Pemphigus Foliaceus and Graves' Disease. ( 27981628 )
2016
2
Differential HLA class I and class II associations in pemphigus foliaceus and pemphigus vulgaris patients from a prevalent Southeastern Brazilian region. ( 27178774 )
2016
3
Non-drug-induced pemphigus foliaceus in a patient with rheumatoid arthritis. ( 27023089 )
2016
4
A 3'UTR polymorphism marks differential KLRG1 mRNA levels through disruption of a miR-584-5p binding site and associates with pemphigus foliaceus susceptibility. ( 27424220 )
2016
5
Systemic lupus erythematosus associated with myasthenia gravis, pemphigus foliaceus and chronic thyroiditis after thymectomy. ( 27270472 )
2016
6
Patients with pemphigus foliaceus may retain antibody reactivity against calcium-stabilized, distal desmoglein 1 domains in remission. ( 26790650 )
2016
7
Infektionsassoziiertes gemeinsames Auftreten von Psoriasis pustulosa, Pemphigus foliaceus und leukozyoklastischer Vaskulitis. ( 27509422 )
2016
8
Childhood Pemphigus Foliaceus with Exclusive Immunoglobulin G Autoantibodies to Desmocollins. ( 26758100 )
2016
9
Pemphigus foliaceus with circinated plaques and neutrophil pustules. ( 27514363 )
2016
10
Pemphigus foliaceus induced by topical 5-fluorouracil. ( 26879697 )
2016
11
Pemphigus foliaceus associated with Hypericum perforatum. ( 27579342 )
2016
12
Non-pathogenic pemphigus foliaceus (PF) IgG acts synergistically with a directly pathogenic PF IgG to increase blistering by p38MAPK-dependent desmoglein 1 clustering. ( 28024684 )
2016
13
Overlapping IgG4 Responses to Self- and Environmental Antigens in Endemic Pemphigus Foliaceus. ( 26826247 )
2016
14
Pemphigus foliaceus exacerbated by radiation, in association with myasthenia gravis. ( 27136623 )
2016
15
Coincidence of annular pustular psoriasis, pemphigus foliaceus, and leukocytoclastic vasculitis associated with chronic cholecystitis. ( 27509423 )
2016
16
Increased serum levels of vascular endothelial growth factor in pemphigus foliaceus patients with erythroderma. ( 27510449 )
2016
17
Prediction of survival for patients with pemphigus vulgaris and pemphigus foliaceus: a retrospective cohort study. ( 25896794 )
2015
18
Evaluation of blood and urinary mercury in pemphigus vulgaris and pemphigus foliaceus patients and its comparison with control group. ( 25751363 )
2015
19
Diaminodiphenyl sulfone-induced eosinophilic pneumonia in a patient with pemphigus foliaceus. ( 26055208 )
2015
20
A case of pemphigus foliaceus aggravated in an irradiated area by radiotherapy against breast cancer. ( 25657410 )
2015
21
Pemphigus Foliaceus Complicated by Kaposi Varicelliform Eruption. ( 26724884 )
2015
22
Update on fogo selvagem, an endemic form of pemphigus foliaceus. ( 25558948 )
2015
23
Coexistence of pemphigus foliaceus and acquired hemophilia A: A case report. ( 25855134 )
2015
24
CTLA4 overexpressing adipose tissue-derived mesenchymal stem cell therapy in a dog with steroid-refractory pemphigus foliaceus. ( 25889154 )
2015
25
Epitope analysis of antidesmoglein 1 autoantibodies from patients with pemphigus foliaceus across different activity stages. ( 26294113 )
2015
26
Canine pemphigus foliaceus with concurrent immune-mediated thrombocytopenia. ( 25415212 )
2015
27
Oral glucocorticoid pulse therapy for induction of treatment of canine pemphigus foliaceus - a comparative study. ( 26248494 )
2015
28
Pemphigus foliaceus occurring with adenocarcinoma of prostate. ( 26261142 )
2015
29
Is there any relationship between polymorphism of Heat Shock Protein 70 genes and Pemphigus foliaceus? ( 25687737 )
2015
30
Treatment of pemphigus vulgaris and pemphigus foliaceus: a systematic review and meta-analysis. ( 25403548 )
2014
31
Demodicidosis on the arms of a patient with pemphigus foliaceus. ( 25128143 )
2014
32
Rapid transition from pemphigus vulgaris to pemphigus foliaceus. ( 25376758 )
2014
33
Antibodies to the amino-terminal domain of desmoglein 1 are retained during transition from pemphigus vulgaris to pemphigus foliaceus. ( 24776707 )
2014
34
Presence of autoimmune regulator and absence of desmoglein 1 in thymoma associated with a pemphigus foliaceus patient. ( 25523433 )
2014
35
Localized pemphigus foliaceus with unilateral facial involvement. ( 24784930 )
2014
36
Locations of acantholysis in pemphigus vulgaris and pemphigus foliaceus. ( 25265985 )
2014
37
The value of trichoscopy in the differential diagnosis of scalp lesions in pemphigus vulgaris and pemphigus foliaceus. ( 25387515 )
2014
38
Rituximab therapy in pemphigus foliaceus: report of 12 cases and review of recent literature. ( 25496559 )
2014
39
A rare case of annular pustular psoriasis associated with pemphigus foliaceus. ( 24882987 )
2014
40
Evaluation of cases of pemphigus vulgaris and pemphigus foliaceus from a reference service in ParA! state, Brazil. ( 25054740 )
2014
41
Fipronil-amitraz-S-methoprene-triggered pemphigus foliaceus in 21 dogs: clinical, histological and immunological characteristics. ( 24666660 )
2014
42
Genome-wide gene expression profiling reveals unsuspected molecular alterations in pemphigus foliaceus. ( 24813052 )
2014
43
A blistering response: concurrent psoriasis and pemphigus foliaceus. ( 25239159 )
2014
44
Mycophenolate mofetil and enteric-coated mycophenolate sodium in the treatment of pemphigus vulgaris and pemphigus foliaceus. ( 24521072 )
2014
45
Pemphigus foliaceus. ( 25526343 )
2014
46
JID VisualDx Quiz: August 2014: pemphigus foliaceus. ( 25029324 )
2014
47
Serum autoantibody profiles of IgA, IgE and IgM in canine pemphigus foliaceus. ( 24975693 )
2014
48
Exacerbation of Pemphigus Foliaceus After Electron-beam Radiation. ( 24626406 )
2014
49
A patient with pemphigus foliaceus and myasthenia gravis treated by a cortisol-secreting adrenal adenoma. ( 24931108 )
2014
50
Pemphigus Foliaceus in an Adolescent. ( 25151193 )
2014

Variations for Pemphigus Foliaceus

Expression for Pemphigus Foliaceus

Search GEO for disease gene expression data for Pemphigus Foliaceus.

Pathways for Pemphigus Foliaceus

Pathways related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.95 DSG1 DSG2 DSG3 DSP EVPL PPL
2
Show member pathways
11.56 DSG1 DSG2 DSG3 DSP EVPL PPL
3
Show member pathways
11.52 DSG1 DSG2 DSG3 DSP
4
Show member pathways
11.29 DSP DST EVPL PPL
5 11.07 DSG1 HLA-DRB1

GO Terms for Pemphigus Foliaceus

Cellular components related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.91 DSG1 DSG2 DSG3 DSP DST HLA-DRB1
2 extracellular exosome GO:0070062 9.86 DSG1 DSG2 DSG3 DSP DST EVPL
3 cytoskeleton GO:0005856 9.78 DSP DST EVPL PPL
4 cell junction GO:0030054 9.7 DSG1 DSG2 DSG3 DSP DST EVPL
5 cell-cell junction GO:0005911 9.5 DSG1 DSG2 DSP
6 ficolin-1-rich granule membrane GO:0101003 9.46 DSG1 DSP
7 lateral plasma membrane GO:0016328 9.43 DSG1 DSG2
8 cornified envelope GO:0001533 9.43 DSG1 DSG2 DSG3 DSP EVPL PPL
9 intercalated disc GO:0014704 9.4 DSG2 DSP
10 desmosome GO:0030057 9.1 DSG1 DSG2 DSG3 DSP EVPL PPL

Biological processes related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.73 DSG1 DSG2 DSG3 DST
2 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.54 DSG1 DSG2 DSG3
3 keratinocyte differentiation GO:0030216 9.52 DSP EVPL
4 peptide cross-linking GO:0018149 9.51 DSP EVPL
5 response to progesterone GO:0032570 9.49 DSG1 DSG2
6 regulation of heart rate by cardiac conduction GO:0086091 9.48 DSG2 DSP
7 maternal process involved in female pregnancy GO:0060135 9.46 DSG1 DSG2
8 keratinization GO:0031424 9.43 DSG1 DSG2 DSG3 DSP EVPL PPL
9 intermediate filament cytoskeleton organization GO:0045104 9.4 DSP DST
10 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.32 DSG2 DSP
11 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 9.26 DSG2 DSP
12 desmosome organization GO:0002934 9.16 DSG2 DSP
13 cornification GO:0070268 9.1 DSG1 DSG2 DSG3 DSP EVPL PPL

Molecular functions related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein binding, bridging GO:0030674 9.26 DSP EVPL
2 calcium ion binding GO:0005509 9.26 DSG1 DSG2 DSG3 DST
3 cell adhesion molecule binding GO:0050839 9.16 DSG2 DSP
4 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 8.62 DSG2 DSP

Sources for Pemphigus Foliaceus

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11 DGIdb
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18 FMA
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33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
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37 KEGG
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48 NDF-RT
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54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
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70 UMLS via Orphanet
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