MCID: PMP004
MIFTS: 39

Pemphigus Foliaceus malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Pemphigus Foliaceus

About this section
Sources:
30ICD10, 31ICD10 via Orphanet, 35LifeMap Discovery®, 48NIH Rare Diseases, 50Novoseek, 54Orphanet, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Pemphigus Foliaceus:

Name: Pemphigus Foliaceus 35 48 54 50 68
 
Pf 48

Classifications:

Orphanet: 54 
Rare skin diseases


External Ids:

Orphanet54 ORPHA79481
UMLS via Orphanet69 C0263313
ICD10 via Orphanet31 L10.2
ICD1030 L10.2

Summaries for Pemphigus Foliaceus

About this section
Wikipedia:71 Pemphigus foliaceus is an autoimmune blistering disease of the skin with characteristic lesions that are... more...

MalaCards based summary: Pemphigus Foliaceus, also known as pf, is related to impetigo and usher syndrome, and has symptoms including acantholysis, Array and Array. An important gene associated with Pemphigus Foliaceus is DSG1 (Desmoglein 1), and among its related pathways are Staphylococcus aureus infection and Alpha6-Beta4 Integrin Signaling Pathway. Affiliated tissues include skin, neutrophil and t cells.

Related Diseases for Pemphigus Foliaceus

About this section

Diseases related to Pemphigus Foliaceus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1impetigo29.1DSG1, DSP, DST
2usher syndrome28.9DSG2, DSP
3pemphigus and fogo selvagem11.2
4pemphigus11.1
5pemphigus vulgaris10.7
6herpetiform pemphigus10.6
7meningococcal meningitis10.3DSG1, DSG3
8bullous pemphigoid10.3
9psoriasis10.2
10skin amelanotic melanoma10.2DSG1, DSG3
11myasthenia gravis10.2
12dermatitis10.2
13paraneoplastic pemphigus10.2
14giant ganglionic hyperplasia10.1DST, HLA-DRB1
15malignant histiocytosis10.1DSG1, DST
16thymoma10.1
17lipomatosis10.0DSG1, DSG2
18acute poisoning by drugs with membrane-stabilizing effect10.0DSG1, DSP
19cardiomyopathy, dilated, 1bb10.0DSG1, DSP
20rheumatoid arthritis10.0
21systemic lupus erythematosus10.0
22alopecia10.0
23arthritis10.0
24lymphoma10.0
25lupus erythematosus10.0
26sacrococcygeal dysgenesis association9.9DSG1, DSG3, DST
27peri-anal fistula9.9DSG1, DST, HLA-DRB1
28gastric cardia carcinoma9.9DSG1, DSP
29hepatitis9.9
30dermatomyositis9.9
31sarcoma9.9
32graves' disease9.9
33prostatitis9.9
34acanthosis nigricans9.9
35porokeratosis9.9
36thyroiditis9.9
37lichen planus9.9
38alopecia areata9.9
39oral lichen planus9.9
40pustular psoriasis9.9
41bullous impetigo9.9
42laryngeal disease9.9DSG1, DSP
43frontotemporal dementia, right temporal atrophy variant9.8DSG2, DSP
44fixed pigmented erythema9.8DSG2, DSP
45ketamine-induced biliary dilatation9.8DSG2, DSP
46atrial standstill, digenic9.7DSG2, DSP
47hiv-19.7
48prostate cancer9.7
49hepatocellular carcinoma9.7
50breast cancer9.7

Graphical network of the top 20 diseases related to Pemphigus Foliaceus:



Diseases related to pemphigus foliaceus

Symptoms & Phenotypes for Pemphigus Foliaceus

About this section

Human phenotypes related to Pemphigus Foliaceus:

 64 54 (show all 6)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 acantholysis64 54 hallmark (90%) Very frequent (99-80%) HP:0100792
2 crusting erythematous dermatitis54 Very frequent (99-80%)
3 abnormal blistering of the skin54 Very frequent (99-80%)
4 erythema54 Very frequent (99-80%)
5 skin vesicle54 Very frequent (99-80%)
6 skin erosion54 Very frequent (99-80%)

Drugs & Therapeutics for Pemphigus Foliaceus

About this section

Interventional clinical trials:

idNameStatusNCT IDPhase
1Autoimmune Blistering Diseases StudyRecruitingNCT02753777

Search NIH Clinical Center for Pemphigus Foliaceus

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Pemphigus Foliaceus cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pemphigus Foliaceus:
Hematopoietic stem cells for pemphigus

Genetic Tests for Pemphigus Foliaceus

About this section

Anatomical Context for Pemphigus Foliaceus

About this section

MalaCards organs/tissues related to Pemphigus Foliaceus:

36
Skin, Neutrophil, T cells, Testes, B cells, Prostate, Thyroid

Publications for Pemphigus Foliaceus

About this section

Articles related to Pemphigus Foliaceus:

(show top 50)    (show all 553)
idTitleAuthorsYear
1
Overlapping IgG4 Responses to Self- and Environmental Antigens in Endemic Pemphigus Foliaceus. (26826247)
2016
2
Concurrent Pemphigus Foliaceus and Graves' Disease. (27981628)
2016
3
Coincidence of annular pustular psoriasis, pemphigus foliaceus, and leukocytoclastic vasculitis associated with chronic cholecystitis. (27509423)
2016
4
Non-pathogenic pemphigus foliaceus (PF) IgG acts synergistically with a directly pathogenic PF IgG to increase blistering by p38MAPK-dependent desmoglein 1 clustering. (28024684)
2016
5
Pemphigus foliaceus exacerbated by radiation, in association with myasthenia gravis. (27136623)
2016
6
Childhood Pemphigus Foliaceus with Exclusive Immunoglobulin G Autoantibodies to Desmocollins. (26758100)
2016
7
Differential HLA class I and class II associations in pemphigus foliaceus and pemphigus vulgaris patients from a prevalent Southeastern Brazilian region. (27178774)
2016
8
Systemic lupus erythematosus associated with myasthenia gravis, pemphigus foliaceus and chronic thyroiditis after thymectomy. (27270472)
2016
9
A 3'UTR polymorphism marks differential KLRG1 mRNA levels through disruption of a miR-584-5p binding site and associates with pemphigus foliaceus susceptibility. (27424220)
2016
10
Non-drug-induced pemphigus foliaceus in a patient with rheumatoid arthritis. (27023089)
2016
11
Pemphigus foliaceus induced by topical 5-fluorouracil. (26879697)
2016
12
Patients with pemphigus foliaceus may retain antibody reactivity against calcium-stabilized, distal desmoglein 1 domains in remission. (26790650)
2016
13
Infektionsassoziiertes gemeinsames Auftreten von Psoriasis pustulosa, Pemphigus foliaceus und leukozyoklastischer Vaskulitis. (27509422)
2016
14
Pemphigus foliaceus associated with Hypericum perforatum. (27579342)
2016
15
Pemphigus foliaceus with circinated plaques and neutrophil pustules. (27514363)
2016
16
Increased serum levels of vascular endothelial growth factor in pemphigus foliaceus patients with erythroderma. (27510449)
2016
17
Coexistence of pemphigus foliaceus and acquired hemophilia A: A case report. (25855134)
2015
18
Is there any relationship between polymorphism of Heat Shock Protein 70 genes and Pemphigus foliaceus? (25687737)
2015
19
Update on fogo selvagem, an endemic form of pemphigus foliaceus. (25558948)
2015
20
Canine pemphigus foliaceus with concurrent immune-mediated thrombocytopenia. (25415212)
2015
21
Diaminodiphenyl sulfone-induced eosinophilic pneumonia in a patient with pemphigus foliaceus. (26055208)
2015
22
Pemphigus foliaceus occurring with adenocarcinoma of prostate. (26261142)
2015
23
Prediction of survival for patients with pemphigus vulgaris and pemphigus foliaceus: a retrospective cohort study. (25896794)
2015
24
Evaluation of blood and urinary mercury in pemphigus vulgaris and pemphigus foliaceus patients and its comparison with control group. (25751363)
2015
25
Pemphigus Foliaceus Complicated by Kaposi Varicelliform Eruption. (26724884)
2015
26
CTLA4 overexpressing adipose tissue-derived mesenchymal stem cell therapy in a dog with steroid-refractory pemphigus foliaceus. (25889154)
2015
27
Epitope analysis of antidesmoglein 1 autoantibodies from patients with pemphigus foliaceus across different activity stages. (26294113)
2015
28
A case of pemphigus foliaceus aggravated in an irradiated area by radiotherapy against breast cancer. (25657410)
2015
29
Oral glucocorticoid pulse therapy for induction of treatment of canine pemphigus foliaceus - a comparative study. (26248494)
2015
30
Presence of autoimmune regulator and absence of desmoglein 1 in thymoma associated with a pemphigus foliaceus patient. (25523433)
2014
31
Locations of acantholysis in pemphigus vulgaris and pemphigus foliaceus. (25265985)
2014
32
A rare case of annular pustular psoriasis associated with pemphigus foliaceus. (24882987)
2014
33
A blistering response: concurrent psoriasis and pemphigus foliaceus. (25239159)
2014
34
The value of trichoscopy in the differential diagnosis of scalp lesions in pemphigus vulgaris and pemphigus foliaceus. (25387515)
2014
35
Rapid transition from pemphigus vulgaris to pemphigus foliaceus. (25376758)
2014
36
JID VisualDx Quiz: August 2014: pemphigus foliaceus. (25029324)
2014
37
Exacerbation of Pemphigus Foliaceus After Electron-beam Radiation. (24626406)
2014
38
Evaluation of cases of pemphigus vulgaris and pemphigus foliaceus from a reference service in ParA! state, Brazil. (25054740)
2014
39
Localized pemphigus foliaceus with unilateral facial involvement. (24784930)
2014
40
Pemphigus foliaceus. (25526343)
2014
41
Mycophenolate mofetil and enteric-coated mycophenolate sodium in the treatment of pemphigus vulgaris and pemphigus foliaceus. (24521072)
2014
42
Fipronil-amitraz-S-methoprene-triggered pemphigus foliaceus in 21 dogs: clinical, histological and immunological characteristics. (24666660)
2014
43
Treatment of pemphigus vulgaris and pemphigus foliaceus: a systematic review and meta-analysis. (25403548)
2014
44
Antibodies to the amino-terminal domain of desmoglein 1 are retained during transition from pemphigus vulgaris to pemphigus foliaceus. (24776707)
2014
45
Genome-wide gene expression profiling reveals unsuspected molecular alterations in pemphigus foliaceus. (24813052)
2014
46
Pemphigus Foliaceus in an Adolescent. (25151193)
2014
47
Erythema annulare-like acantholytic dermatosis: a subset of pemphigus foliaceus. (24836841)
2014
48
Serum autoantibody profiles of IgA, IgE and IgM in canine pemphigus foliaceus. (24975693)
2014
49
Demodicidosis on the arms of a patient with pemphigus foliaceus. (25128143)
2014
50
A patient with pemphigus foliaceus and myasthenia gravis treated by a cortisol-secreting adrenal adenoma. (24931108)
2014

Variations for Pemphigus Foliaceus

About this section

Expression for genes affiliated with Pemphigus Foliaceus

About this section
Search GEO for disease gene expression data for Pemphigus Foliaceus.

Pathways for genes affiliated with Pemphigus Foliaceus

About this section

GO Terms for genes affiliated with Pemphigus Foliaceus

About this section

Cellular components related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cornified envelopeGO:000153310.1DSP, EVPL
2intercalated discGO:00147049.6DSG2, DSP
3cell-cell junctionGO:00059119.5DSG1, DSG2, DSP
4lateral plasma membraneGO:00163289.3DSG1, DSG2
5desmosomeGO:00300577.9DSG1, DSG2, DSG3, DSP, EVPL, PPL
6extracellular exosomeGO:00700626.9DSG1, DSG2, DSG3, DSP, DST, EVPL

Biological processes related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1intermediate filament cytoskeleton organizationGO:004510410.2DSP, DST
2epidermis developmentGO:000854410.0DSP, EVPL
3keratinizationGO:00314249.9EVPL, PPL
4keratinocyte differentiationGO:00302169.9DSP, EVPL
5maternal process involved in female pregnancyGO:00601359.9DSG1, DSG2
6peptide cross-linkingGO:00181499.8DSP, EVPL
7bundle of His cell-Purkinje myocyte adhesion involved in cell communicationGO:00860739.8DSG2, DSP
8desmosome organizationGO:00029349.8DSG2, DSP
9regulation of heart rate by cardiac conductionGO:00860919.6DSG2, DSP
10regulation of ventricular cardiac muscle cell action potentialGO:00989119.6DSG2, DSP
11homophilic cell adhesion via plasma membrane adhesion moleculesGO:00071569.5DSG1, DSG2, DSG3
12response to progesteroneGO:00325709.3DSG1, DSG2

Molecular functions related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein binding, bridgingGO:00306749.9DSP, EVPL
2cell adhesion molecule bindingGO:00508399.7DSG2, DSP
3cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communicationGO:00860839.7DSG2, DSP
4structural constituent of cytoskeletonGO:00052009.4DSP, PPL
5calcium ion bindingGO:00055099.1DSG1, DSG2, DSG3, DST

Sources for Pemphigus Foliaceus

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet