MCID: PMP004
MIFTS: 46

Pemphigus Foliaceus

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Pemphigus Foliaceus

MalaCards integrated aliases for Pemphigus Foliaceus:

Name: Pemphigus Foliaceus 37 72 49 55 51 69
Pf 49

Classifications:

Orphanet: 55  
Rare skin diseases


External Ids:

Orphanet 55 ORPHA79481
UMLS via Orphanet 70 C0263313
ICD10 via Orphanet 33 L10.2
ICD10 32 L10.2
UMLS 69 C0263313

Summaries for Pemphigus Foliaceus

MalaCards based summary : Pemphigus Foliaceus, also known as pf, is related to pemphigus and herpetiform pemphigus, and has symptoms including crusting erythematous dermatitis, abnormal blistering of the skin and erythema. An important gene associated with Pemphigus Foliaceus is DSG1 (Desmoglein 1), and among its related pathways/superpathways are Developmental Biology and Keratinization. Affiliated tissues include skin, t cells and neutrophil.

Wikipedia : 72 Pemphigus (/ˈpɛmfɪɡəs/ or /pɛmˈfaɪɡəs/) is a rare group of blistering autoimmune diseases that affect... more...

Related Diseases for Pemphigus Foliaceus

Diseases related to Pemphigus Foliaceus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
# Related Disease Score Top Affiliating Genes
1 pemphigus 31.0 DSG1 DSG2 DSG3 DST EVPL PPL
2 herpetiform pemphigus 30.8 DSG1 DSG3 DST
3 bullous impetigo 30.3 DSG1 DSG3
4 thymoma 29.5 CTLA4 EVPL PPL
5 skin disease 29.4 DSG1 DSG3 DST
6 lichen planus 29.4 DSG3 DST
7 autoimmune disease 29.3 CTLA4 DSG1 HLA-DRB1
8 pemphigus vulgaris 28.9 DSG1 DSG2 DSG3 DST EVPL HLA-DRB1
9 bullous pemphigoid 28.8 DSG1 DSG3 DST EVPL HLA-DRB1 PPL
10 paraneoplastic pemphigus 28.1 DSG1 DSG2 DSG3 DST EVPL HLA-DRB1
11 pemphigus erythematosus 11.5
12 pemphigus and fogo selvagem 11.4
13 pemphigus vulgaris, familial 10.8
14 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.4
15 pustulosis of palm and sole 10.3
16 psoriasis 10.3
17 myasthenia gravis 10.3
18 dermatitis 10.3
19 myasthenia gravis congenital 10.3
20 pemphigus vegetans 10.2 DSG1 PPL
21 nodular malignant melanoma 10.2 DSG1 DSG3
22 thymoma, familial 10.2
23 ritter's disease 10.1 DSG1 DSG2
24 blood group, i system 10.1
25 alopecia 10.1
26 mucositis 10.1
27 pemphigoid gestationis 10.1 DST HLA-DRB1
28 systemic lupus erythematosus 10.0
29 rheumatoid arthritis 10.0
30 autoimmune disease 1 10.0
31 arthritis 10.0
32 lymphoma 10.0
33 lupus erythematosus 10.0
34 lichen disease 10.0 DSG1 DST
35 acanthosis nigricans 10.0
36 psoriasis 2 10.0
37 psoriasis 7 10.0
38 psoriasis 11 10.0
39 psoriasis 13 10.0
40 hepatitis 10.0
41 dermatomyositis 10.0
42 sarcoma 10.0
43 graves' disease 10.0
44 prostatitis 10.0
45 squamous cell carcinoma 10.0
46 porokeratosis 10.0
47 thyroiditis 10.0
48 impetigo 10.0
49 alopecia areata 10.0
50 oral lichen planus 10.0

Graphical network of the top 20 diseases related to Pemphigus Foliaceus:



Diseases related to Pemphigus Foliaceus

Symptoms & Phenotypes for Pemphigus Foliaceus

Human phenotypes related to Pemphigus Foliaceus:

55 31 (show all 6)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 crusting erythematous dermatitis 55 31 hallmark (90%) Very frequent (99-80%) HP:0007473
2 abnormal blistering of the skin 55 31 hallmark (90%) Very frequent (99-80%) HP:0008066
3 erythema 55 31 hallmark (90%) Very frequent (99-80%) HP:0010783
4 acantholysis 55 31 hallmark (90%) Very frequent (99-80%) HP:0100792
5 skin vesicle 55 31 hallmark (90%) Very frequent (99-80%) HP:0200037
6 skin erosion 55 31 hallmark (90%) Very frequent (99-80%) HP:0200041

Drugs & Therapeutics for Pemphigus Foliaceus

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Polyclonal Regulatory T Cells (PolyTregs) for Pemphigus Recruiting NCT03239470 Phase 1
2 A Safety Study of SYNT001 in Subjects With Pemphigus (Vulgaris or Foliaceus) Recruiting NCT03075904 Phase 1 SYNT001
3 Autoimmune Blistering Diseases Study Recruiting NCT02753777

Search NIH Clinical Center for Pemphigus Foliaceus

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Pemphigus Foliaceus cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pemphigus Foliaceus:
Hematopoietic stem cells for pemphigus

Genetic Tests for Pemphigus Foliaceus

Anatomical Context for Pemphigus Foliaceus

MalaCards organs/tissues related to Pemphigus Foliaceus:

38
Skin, T Cells, Neutrophil, Testes, B Cells, Prostate, Thyroid

Publications for Pemphigus Foliaceus

Articles related to Pemphigus Foliaceus:

(show top 50) (show all 587)
# Title Authors Year
1
Patients affected by endemic pemphigus foliaceus in Colombia, South America exhibit autoantibodies to optic nerve sheath envelope cell junctions. ( 29445566 )
2018
2
A Case of Concomitant Pemphigus Foliaceus and Oral Pemphigus Vulgaris. ( 29340948 )
2018
3
Pemphigus trigger factors: special focus on pemphigus vulgaris and pemphigus foliaceus. ( 29110080 )
2018
4
Autoimmunity and cardiac arrhythmias in endemic pemphigus foliaceus-Association, correlation, or causation? ( 29369789 )
2018
5
Pathogenic IgG4 autoantibodies from endemic pemphigus foliaceus recognize a desmoglein-1 conformational epitope. ( 29307589 )
2018
6
Successful treatment of pemphigus foliaceus in a Berrichon du Cher ram with methylprednisolone acetate. ( 28378419 )
2017
7
Myiasis in a neglected case of generalized erythrodermic pemphigus foliaceus. ( 28366917 )
2017
8
Pemphigus Vulgaris and Pemphigus Foliaceus: Differences in Epidemiology and Mortality. ( 28536732 )
2017
9
Miniaturization of sebaceous glands: A novel histopathological finding in pemphigus vulgaris and pemphigus foliaceus of the scalp. ( 28632917 )
2017
10
Patients with a new variant of endemic pemphigus foliaceus have autoantibodies against arrector pili muscle, colocalizing with MYZAP, p0071, desmoplakins 1 and 2 and ARVCF. ( 29034528 )
2017
11
Using immune checkpoint inhibitors without exacerbation in a melanoma patient with pemphigus foliaceus. ( 28762466 )
2017
12
Evaluation of C-reactive protein as an inflammatory marker of pemphigus foliaceus and superficial pyoderma in dogs. ( 29168248 )
2017
13
Pemphigus Foliaceus Demonstrating Pathergy After Mohs Micrographic Surgery. ( 29293109 )
2017
14
Rituximab and short-course prednisone as the new gold standard for new-onset pemphigus vulgaris and pemphigus foliaceus. ( 29192985 )
2017
15
Alopecia developed in a transitional case from pemphigus foliaceus to pemphigus vulgaris. ( 28681532 )
2017
16
Localized pemphigus foliaceus. ( 28207020 )
2017
17
Refractory pemphigus foliaceus associated with herpesvirus infection: case report. ( 28793012 )
2017
18
The Use of Intralesional Steroids in a Case of Localized Pemphigus Foliaceus. ( 28868007 )
2017
19
Is ciclosporin an effective treatment for canine pemphigus foliaceus? ( 29175932 )
2017
20
Rituximab in the management of juvenile pemphigus foliaceus. ( 28633733 )
2017
21
A case of IgA pemphigus foliaceus with high scores on drug-induced lymphocyte stimulation tests secondary to various drugs. ( 29165304 )
2017
22
Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern Brazil. ( 28941730 )
2017
23
CD59 polymorphisms are associated with gene expression and different sexual susceptibility to pemphigus foliaceus. ( 28534443 )
2017
24
HLA class II alleles of susceptibility and protection in Brazilian and Dutch pemphigus foliaceus. ( 28977698 )
2017
25
Putative contact ketoconazole shampoo-triggered pemphigus foliaceus in a dog. ( 28878412 )
2017
26
Herpes simplex virus 1 and cytomegalovirus are associated with pemphigus vulgaris but not with pemphigus foliaceus disease. ( 28370424 )
2017
27
Pemphigus vulgaris and pemphigus foliaceus determined by CD86 and CTLA4 polymorphisms. ( 28274366 )
2017
28
Cytokine and Chemokines Alterations in the Endemic Form of Pemphigus Foliaceus (Fogo Selvagem). ( 28855908 )
2017
29
Divergent Specificity Development of IgG1 and IgG4 Autoantibodies in Endemic Pemphigus Foliaceus (Fogo Selvagem). ( 28868524 )
2017
30
Pemphigus foliaceus as a differential diagnosis in vesicobullous lesions. ( 28767922 )
2017
31
Role of FOXP3 gene polymorphism in the susceptibility to Tunisian endemic Pemphigus Foliaceus. ( 28216259 )
2017
32
Cell junction protein armadillo repeat gene deleted in velo-cardio-facial syndrome is expressed in the skin and colocalizes with autoantibodies of patients affected by a new variant of endemic pemphigus foliaceus in Colombia. ( 29214101 )
2017
33
IgA multiple myeloma in a patient with an IgG pemphigus foliaceus-like exanthem. ( 28856664 )
2017
34
Pemphigus foliaceus with pustular presentation in a patient with psoriasis. ( 29267466 )
2017
35
Pemphigus foliaceus induced by topical 5-fluorouracil. ( 26879697 )
2016
36
Childhood Pemphigus Foliaceus with Exclusive Immunoglobulin G Autoantibodies to Desmocollins. ( 26758100 )
2016
37
A 3'UTR polymorphism marks differential KLRG1 mRNA levels through disruption of a miR-584-5p binding site and associates with pemphigus foliaceus susceptibility. ( 27424220 )
2016
38
Non-drug-induced pemphigus foliaceus in a patient with rheumatoid arthritis. ( 27023089 )
2016
39
Pemphigus foliaceus exacerbated by radiation, in association with myasthenia gravis. ( 27136623 )
2016
40
Pemphigus foliaceus with circinated plaques and neutrophil pustules. ( 27514363 )
2016
41
Systemic lupus erythematosus associated with myasthenia gravis, pemphigus foliaceus and chronic thyroiditis after thymectomy. ( 27270472 )
2016
42
Coincidence of annular pustular psoriasis, pemphigus foliaceus, and leukocytoclastic vasculitis associated with chronic cholecystitis. ( 27509423 )
2016
43
Overlapping IgG4 Responses to Self- and Environmental Antigens in Endemic Pemphigus Foliaceus. ( 26826247 )
2016
44
Concurrent Pemphigus Foliaceus and Graves' Disease. ( 27981628 )
2016
45
Pemphigus foliaceus associated with Hypericum perforatum. ( 27579342 )
2016
46
Differential HLA class I and class II associations in pemphigus foliaceus and pemphigus vulgaris patients from a prevalent Southeastern Brazilian region. ( 27178774 )
2016
47
Increased serum levels of vascular endothelial growth factor in pemphigus foliaceus patients with erythroderma. ( 27510449 )
2016
48
Patients with pemphigus foliaceus may retain antibody reactivity against calcium-stabilized, distal desmoglein 1 domains in remission. ( 26790650 )
2016
49
Non-pathogenic pemphigus foliaceus (PF) IgG acts synergistically with a directly pathogenic PF IgG to increase blistering by p38MAPK-dependent desmoglein 1 clustering. ( 28024684 )
2016
50
Infektionsassoziiertes gemeinsames Auftreten von Psoriasis pustulosa, Pemphigus foliaceus und leukozyoklastischer Vaskulitis. ( 27509422 )
2016

Variations for Pemphigus Foliaceus

Expression for Pemphigus Foliaceus

Search GEO for disease gene expression data for Pemphigus Foliaceus.

Pathways for Pemphigus Foliaceus

GO Terms for Pemphigus Foliaceus

Cellular components related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.87 CTLA4 DSG1 DSG2 DSG3 DST HLA-DRB1
2 extracellular exosome GO:0070062 9.8 DSG1 DSG2 DSG3 DST EVPL HLA-DRB1
3 cell junction GO:0030054 9.63 DSG1 DSG2 DSG3 DST EVPL PPL
4 lateral plasma membrane GO:0016328 9.37 DSG1 DSG2
5 cornified envelope GO:0001533 9.35 DSG1 DSG2 DSG3 EVPL PPL
6 desmosome GO:0030057 9.02 DSG1 DSG2 DSG3 EVPL PPL

Biological processes related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.62 DSG1 DSG2 DSG3 DST
2 T cell costimulation GO:0031295 9.43 CTLA4 HLA-DRB1
3 response to progesterone GO:0032570 9.4 DSG1 DSG2
4 negative regulation of T cell proliferation GO:0042130 9.37 CTLA4 HLA-DRB1
5 keratinization GO:0031424 9.35 DSG1 DSG2 DSG3 EVPL PPL
6 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.33 DSG1 DSG2 DSG3
7 maternal process involved in female pregnancy GO:0060135 9.26 DSG1 DSG2
8 cornification GO:0070268 9.02 DSG1 DSG2 DSG3 EVPL PPL

Molecular functions related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 8.92 DSG1 DSG2 DSG3 DST

Sources for Pemphigus Foliaceus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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