MCID: PMP004
MIFTS: 38

Pemphigus Foliaceus malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Pemphigus Foliaceus

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Sources:
32LifeMap Discovery®, 45NIH Rare Diseases, 47Novoseek, 51Orphanet, 65UMLS, 66UMLS via Orphanet, 28ICD10 via Orphanet, 27ICD10
See all MalaCards sources

Aliases & Descriptions for Pemphigus Foliaceus:

Name: Pemphigus Foliaceus 32 45 47 51 65
 
Pf 45

Classifications:

Orphanet: 51 
Rare skin diseases


External Ids:

Orphanet51 79481
UMLS via Orphanet66 C0263313
ICD10 via Orphanet28 L10.2
ICD1027 L10.2
UMLS65 C0263313

Summaries for Pemphigus Foliaceus

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Wikipedia:68 Pemphigus foliaceus is an autoimmune blistering disease of the skin with characteristic lesions that are... more...

MalaCards based summary: Pemphigus Foliaceus, also known as pf, is related to pemphigus and fogo selvagem and pemphigus vulgaris, and has symptoms including acantholysisand positive nikolski's sign/achantolysis. An important gene associated with Pemphigus Foliaceus is DSG1 (Desmoglein 1), and among its related pathways are Staphylococcus aureus infection and Apoptotic cleavage of cellular proteins. Affiliated tissues include skin, b cells and breast.

Related Diseases for Pemphigus Foliaceus

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Graphical network of the top 20 diseases related to Pemphigus Foliaceus:



Diseases related to pemphigus foliaceus

Symptoms for Pemphigus Foliaceus

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Symptoms:

 51
  • positive nikolski's sign/achantolysis

HPO human phenotypes related to Pemphigus Foliaceus:

id Description Frequency HPO Source Accession
1 acantholysis hallmark (90%) HP:0100792

Drugs & Therapeutics for Pemphigus Foliaceus

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Autoimmune Blistering Diseases StudyRecruitingNCT02753777

Search NIH Clinical Center for Pemphigus Foliaceus

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Pemphigus Foliaceus cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pemphigus Foliaceus:
Hematopoietic stem cells for pemphigus

Genetic Tests for Pemphigus Foliaceus

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Anatomical Context for Pemphigus Foliaceus

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MalaCards organs/tissues related to Pemphigus Foliaceus:

33
Skin, B cells, Breast, Thyroid, Liver, T cells, Prostate

Animal Models for Pemphigus Foliaceus or affiliated genes

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Publications for Pemphigus Foliaceus

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Articles related to Pemphigus Foliaceus:

(show top 50)    (show all 547)
idTitleAuthorsYear
1
Overlapping IgG4 Responses to Self- and Environmental Antigens in Endemic Pemphigus Foliaceus. (26826247)
2016
2
Differential HLA class I and class II associations in pemphigus foliaceus and pemphigus vulgaris patients from a prevalent Southeastern Brazilian region. (27178774)
2016
3
CTLA4 overexpressing adipose tissue-derived mesenchymal stem cell therapy in a dog with steroid-refractory pemphigus foliaceus. (25889154)
2015
4
Coexistence of pemphigus foliaceus and acquired hemophilia A: A case report. (25855134)
2015
5
Presence of autoimmune regulator and absence of desmoglein 1 in thymoma associated with a pemphigus foliaceus patient. (25523433)
2014
6
Pemphigus foliaceus. (25526343)
2014
7
Biomarkers of oxidative stress in epidermis of Tunisian pemphigus foliaceus patients. (22738420)
2013
8
Both qualitative and quantitative genetic variation of MHC class II molecules may influence susceptibility to autoimmune diseases: the case of endemic pemphigus foliaceus. (23777927)
2013
9
Prognostic factors in pemphigus vulgaris and pemphigus foliaceus. (24102444)
2013
10
Direct immunofluorescence of the outer root sheath in anagen and telogen hair in pemphigus vulgaris and pemphigus foliaceus. (23713982)
2013
11
Palm tissue displaying a polyclonal autoimmune response in patients affected by a new variant of endemic pemphigus foliaceus in Colombia, South America. (19889592)
2010
12
Antigen selection of anti-DSG1 autoantibodies during and before the onset of endemic pemphigus foliaceus. (19571823)
2009
13
Canine pemphigus foliaceus antigen is localized within desmosomes of keratinocyte. (18976819)
2009
14
Anti-desmoglein 1 antibodies in healthy related and unrelated subjects and patients with pemphigus foliaceus in endemic and non-endemic areas from Tunisia. (19453789)
2009
15
Advances in pemphigus and its endemic pemphigus foliaceus (Fogo Selvagem) phenotype: a paradigm of human autoimmunity. (18838249)
2008
16
Tinea incognito hidden under apparently treatment-resistant pemphigus foliaceus. (18480931)
2008
17
Recalcitrant pemphigus foliaceus with Kaposi's varicelliform eruption: report of a fatal case. (18801107)
2008
18
Generalized erythrodermic pemphigus foliaceus in a child and its successful response to rituximab treatment. (17461818)
2007
19
Pemphigus vulgaris and pemphigus foliaceus: similar prognosis? (17822493)
2007
20
Internalization of non-clustered desmoglein 1 without depletion of desmoglein 1 from adhesion complexes in an experimental model of the autoimmune disease pemphigus foliaceus. (17624248)
2007
21
No evidence for association of the TP53 12139 and the BAX-248 polymorphisms with endemic pemphigus foliaceus (fogo selvagem). (16611260)
2006
22
Increased activity of plasma and tissue kallikreins, plasma kininase II and salivary kallikrein in pemphigus foliaceus (fogo selvagem). (15840094)
2005
23
Eyelid skin involvement in pemphigus foliaceus. (16419424)
2005
24
Direct immunofluorescence on uninvolved, lesional and perilesional skin in patients with endemic pemphigus foliaceus (fogo selvagem). (15567982)
2004
25
Treatment of pemphigus vulgaris and pemphigus foliaceus with mycophenolate mofetil. (12810504)
2003
26
Comparative study of autoantigen profile between Colombian and Brazilian types of endemic pemphigus foliaceus by various biochemical and molecular biological techniques. (12788527)
2003
27
Pemphigus foliaceus localized to the nose. (12950358)
2003
28
Endemic Pemphigus foliaceus ("Fogo selvagem"): a series from the Northeastern region of the State of SALo Paulo, Brazil, 1973-1998. (11340476)
2001
29
Commentary/millenium: endemic pemphigus foliaceus (fogo selvagem). (11123439)
2000
30
An interesting case of pemphigus foliaceus in a dog. (10065323)
1999
31
Pemphigus foliaceus induced by psoralen-UV-A. (9801700)
1998
32
Pemphigus foliaceus: an unusual clinical feature and case reports. (9466075)
1998
33
Pemphigus foliaceus and pemphigus vulgaris autoantibodies react with the extracellular domain of desmoglein-1. (7860995)
1995
34
Tests of inflammatory activity in endemic pemphigus foliaceus]. (8008917)
1994
35
Structure of DSG1, the bovine desmosomal cadherin gene encoding the pemphigus foliaceus antigen. Evidence of polymorphism. (8294446)
1994
36
Pemphigus foliaceus treated successfully with plasma exchange. (1478768)
1992
37
Ultrastructural binding site of pemphigus foliaceus autoantibodies: comparison with pemphigus vulgaris. (1918503)
1991
38
Complement activation in Brazilian pemphigus foliaceus. (2805387)
1989
39
Coexistence of psoriasis vulgaris and pemphigus foliaceus. (2620759)
1989
40
The pathogenic effect of IgG4 autoantibodies in endemic pemphigus foliaceus (fogo selvagem). (2654636)
1989
41
Pemphigus foliaceus antigen: characterization of a keratinocyte envelope associated pool and preparation of a soluble immunoreactive fragment. (2474034)
1989
42
Pemphigus foliaceus with anti-intercellular and anti-basement membrane zone antibodies. Blocking immunofluorescence and Western immunoblotting studies. (3069506)
1988
43
Complement fixation by Brazilian Pemphigus foliaceus autoantibodies. (2454770)
1988
44
Pemphigus foliaceus coexisting with toxic, multinodular goiter. (3771047)
1986
45
Concurrent development of pemphigus foliaceus and psoriasis. (4018981)
1985
46
Brazilian pemphigus foliaceus. (7085163)
1982
47
On the association of some dermatoses with South American pemphigus foliaceus. (4371031)
1974
48
49
50

Variations for Pemphigus Foliaceus

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Expression for genes affiliated with Pemphigus Foliaceus

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Search GEO for disease gene expression data for Pemphigus Foliaceus.

Pathways for genes affiliated with Pemphigus Foliaceus

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GO Terms for genes affiliated with Pemphigus Foliaceus

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Cellular components related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell-cell junctionGO:00059119.7DSG1, DSG2
2plasma membraneGO:00058868.4DSG1, DSG2, DSG3, PPL

Biological processes related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to progesteroneGO:00325709.9DSG1, DSG2
2homophilic cell adhesion via plasma membrane adhesion moleculesGO:00071569.4DSG2, DSG3
3apoptotic processGO:00069158.8DSG1, DSG2, DSG3

Sources for Pemphigus Foliaceus

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet