MCID: PMP004
MIFTS: 40

Pemphigus Foliaceus malady

Rare diseases, Skin diseases categories

Aliases & Classifications for Pemphigus Foliaceus

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Sources:
30LifeMap Discovery®, 41NIH Rare Diseases, 43Novoseek, 47Orphanet, 60UMLS, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Pemphigus Foliaceus, Aliases & Descriptions:

Name: Pemphigus Foliaceus 30 41 43 47 60
 
Pf 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases
Orphanet: 47 
Rare skin diseases


External Ids:

Orphanet47 79481
ICD10 via Orphanet26 L10.2
UMLS via Orphanet61 C0263313
ICD1025 L10.2

Summaries for Pemphigus Foliaceus

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Wikipedia:63 Pemphigus foliaceus is an autoimmune blistering disease of the skin with characteristic lesions that are... more...

MalaCards based summary: Pemphigus Foliaceus, also known as pf, is related to bullous pemphigoid and pemphigus, and has symptoms including acantholysisand positive nikolski's sign/achantolysis. An important gene associated with Pemphigus Foliaceus is DSG1 (desmoglein 1), and among its related pathways are Apoptotic cleavage of cellular proteins and Staphylococcus aureus infection. The compounds ivig and rituximab have been mentioned in the context of this disorder. Affiliated tissues include skin, neutrophil and testes.

Related Diseases for Pemphigus Foliaceus

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Graphical network of the top 20 diseases related to Pemphigus Foliaceus:



Diseases related to pemphigus foliaceus

Symptoms for Pemphigus Foliaceus

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Symptoms:

 47
  • positive nikolski's sign/achantolysis

HPO human phenotypes related to Pemphigus Foliaceus:

id Description Frequency HPO Source Accession
1 acantholysis hallmark (90%) HP:0100792

Drugs & Therapeutics for Pemphigus Foliaceus

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Drug clinical trials:

Search ClinicalTrials for Pemphigus Foliaceus

Search NIH Clinical Center for Pemphigus Foliaceus

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Pemphigus Foliaceus cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pemphigus Foliaceus:
Hematopoietic stem cells for pemphigus

Genetic Tests for Pemphigus Foliaceus

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Anatomical Context for Pemphigus Foliaceus

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MalaCards organs/tissues related to Pemphigus Foliaceus:

31
Skin, Neutrophil, Testes, T cells, B cells, Lymph node, Lung, Thyroid, Breast, Prostate

Animal Models for Pemphigus Foliaceus or affiliated genes

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Publications for Pemphigus Foliaceus

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Articles related to Pemphigus Foliaceus:

(show top 50)    (show all 529)
idTitleAuthorsYear
1
CTLA4 overexpressing adipose tissue-derived mesenchymal stem cell therapy in a dog with steroid-refractory pemphigus foliaceus. (25889154)
2015
2
Coexistence of pemphigus foliaceus and acquired hemophilia A: A case report. (25855134)
2015
3
Presence of autoimmune regulator and absence of desmoglein 1 in thymoma associated with a pemphigus foliaceus patient. (25523433)
2014
4
Pemphigus foliaceus. (25526343)
2014
5
Biomarkers of oxidative stress in epidermis of Tunisian pemphigus foliaceus patients. (22738420)
2013
6
Both qualitative and quantitative genetic variation of MHC class II molecules may influence susceptibility to autoimmune diseases: the case of endemic pemphigus foliaceus. (23777927)
2013
7
Prognostic factors in pemphigus vulgaris and pemphigus foliaceus. (24102444)
2013
8
Direct immunofluorescence of the outer root sheath in anagen and telogen hair in pemphigus vulgaris and pemphigus foliaceus. (23713982)
2013
9
Palm tissue displaying a polyclonal autoimmune response in patients affected by a new variant of endemic pemphigus foliaceus in Colombia, South America. (19889592)
2010
10
Antigen selection of anti-DSG1 autoantibodies during and before the onset of endemic pemphigus foliaceus. (19571823)
2009
11
Canine pemphigus foliaceus antigen is localized within desmosomes of keratinocyte. (18976819)
2009
12
Anti-desmoglein 1 antibodies in healthy related and unrelated subjects and patients with pemphigus foliaceus in endemic and non-endemic areas from Tunisia. (19453789)
2009
13
Advances in pemphigus and its endemic pemphigus foliaceus (Fogo Selvagem) phenotype: a paradigm of human autoimmunity. (18838249)
2008
14
Tinea incognito hidden under apparently treatment-resistant pemphigus foliaceus. (18480931)
2008
15
Recalcitrant pemphigus foliaceus with Kaposi's varicelliform eruption: report of a fatal case. (18801107)
2008
16
Generalized erythrodermic pemphigus foliaceus in a child and its successful response to rituximab treatment. (17461818)
2007
17
Pemphigus vulgaris and pemphigus foliaceus: similar prognosis? (17822493)
2007
18
Internalization of non-clustered desmoglein 1 without depletion of desmoglein 1 from adhesion complexes in an experimental model of the autoimmune disease pemphigus foliaceus. (17624248)
2007
19
No evidence for association of the TP53 12139 and the BAX-248 polymorphisms with endemic pemphigus foliaceus (fogo selvagem). (16611260)
2006
20
Increased activity of plasma and tissue kallikreins, plasma kininase II and salivary kallikrein in pemphigus foliaceus (fogo selvagem). (15840094)
2005
21
Eyelid skin involvement in pemphigus foliaceus. (16419424)
2005
22
Direct immunofluorescence on uninvolved, lesional and perilesional skin in patients with endemic pemphigus foliaceus (fogo selvagem). (15567982)
2004
23
Pemphigus foliaceus with neutrophilic spongiosis evolving to an atypical pemphigus phenotype. (15583603)
2004
24
Anti-desmoglein 1 antibodies in Tunisian healthy subjects: arguments for the role of environmental factors in the occurrence of Tunisian pemphigus foliaceus. (15196262)
2004
25
Treatment of pemphigus vulgaris and pemphigus foliaceus with mycophenolate mofetil. (12810504)
2003
26
Comparative study of autoantigen profile between Colombian and Brazilian types of endemic pemphigus foliaceus by various biochemical and molecular biological techniques. (12788527)
2003
27
Pemphigus foliaceus localized to the nose. (12950358)
2003
28
Endemic Pemphigus foliaceus ("Fogo selvagem"): a series from the Northeastern region of the State of SALo Paulo, Brazil, 1973-1998. (11340476)
2001
29
A polymorphic variant of the gene coding desmoglein 1, the target autoantigen of pemphigus foliaceus, is associated with the disease. (11294567)
2001
30
Commentary/millenium: endemic pemphigus foliaceus (fogo selvagem). (11123439)
2000
31
Pemphigus foliaceus associated with silicosis. (10951170)
2000
32
An interesting case of pemphigus foliaceus in a dog. (10065323)
1999
33
Pemphigus foliaceus induced by psoralen-UV-A. (9801700)
1998
34
Pemphigus foliaceus: an unusual clinical feature and case reports. (9466075)
1998
35
Pemphigus foliaceus and pemphigus vulgaris autoantibodies react with the extracellular domain of desmoglein-1. (7860995)
1995
36
Tests of inflammatory activity in endemic pemphigus foliaceus]. (8008917)
1994
37
Structure of DSG1, the bovine desmosomal cadherin gene encoding the pemphigus foliaceus antigen. Evidence of polymorphism. (8294446)
1994
38
Pemphigus foliaceus treated successfully with plasma exchange. (1478768)
1992
39
Ultrastructural binding site of pemphigus foliaceus autoantibodies: comparison with pemphigus vulgaris. (1918503)
1991
40
Complement activation in Brazilian pemphigus foliaceus. (2805387)
1989
41
Coexistence of psoriasis vulgaris and pemphigus foliaceus. (2620759)
1989
42
The pathogenic effect of IgG4 autoantibodies in endemic pemphigus foliaceus (fogo selvagem). (2654636)
1989
43
Pemphigus foliaceus antigen: characterization of a keratinocyte envelope associated pool and preparation of a soluble immunoreactive fragment. (2474034)
1989
44
Pemphigus foliaceus with anti-intercellular and anti-basement membrane zone antibodies. Blocking immunofluorescence and Western immunoblotting studies. (3069506)
1988
45
Complement fixation by Brazilian Pemphigus foliaceus autoantibodies. (2454770)
1988
46
Clinical, histologic, and immunopathologic comparison of pemphigus vulgaris and pemphigus foliaceus. (2978970)
1988
47
Pemphigus foliaceus coexisting with toxic, multinodular goiter. (3771047)
1986
48
Concurrent development of pemphigus foliaceus and psoriasis. (4018981)
1985
49
Brazilian pemphigus foliaceus. (7085163)
1982
50
On the association of some dermatoses with South American pemphigus foliaceus. (4371031)
1974

Variations for Pemphigus Foliaceus

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Expression for genes affiliated with Pemphigus Foliaceus

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Search GEO for disease gene expression data for Pemphigus Foliaceus.

Pathways for genes affiliated with Pemphigus Foliaceus

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Pathways related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6DSG2, DSG1
29.5DSG1, HLA-DRB1
39.2EVPL, DST

Compounds for genes affiliated with Pemphigus Foliaceus

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Sources:
43Novoseek, 49PharmGKB, 12DrugBank, 28IUPHAR, 24HMDB
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Compounds related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1ivig439.8CD79A, DSG1
2rituximab43 49 1211.7DSG1, CD79A
3neopterin439.6PLAUR, CD79A
4allergens439.5CD79A, HLA-DRB1
5suramin43 28 1211.5CD79A, PLAUR
6biotin43 24 1211.2CD79A, PLAUR
7paraffin438.9CD79A, PLAUR, DST
8arginine438.9CD79A, PLAUR, HLA-DRB1
9oligonucleotide438.4HLA-DRB1, DST, PLAUR

GO Terms for genes affiliated with Pemphigus Foliaceus

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Cellular components related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lateral plasma membraneGO:00163289.6DSG2, DSG1
2cell-cell junctionGO:00059119.6DSG2, DSG1
3desmosomeGO:00300579.2EVPL, DSG2, DSG1
4plasma membraneGO:00058867.9HLA-DRB1, DSG1, DSG2, PLAUR, CD79A
5integral component of membraneGO:00160217.5CD79A, PLAUR, DSG2, DSG1, DST

Biological processes related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cellular component disassembly involved in execution phase of apoptosisGO:00069219.6DSG2, DSG1
2maternal process involved in female pregnancyGO:00601359.5DSG2, DSG1
3response to progesteroneGO:00325709.3DSG2, DSG1

Molecular functions related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1calcium ion bindingGO:00055098.8DSG2, DSG1, DST

Products for genes affiliated with Pemphigus Foliaceus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Pemphigus Foliaceus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet