PF
MCID: PMP004
MIFTS: 42

Pemphigus Foliaceus (PF) malady

Skin diseases category

Summaries for Pemphigus Foliaceus

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63Wikipedia, 32MalaCards
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Wikipedia:63 Pemphigus foliaceus is an autoimmune blistering disease of the skin with characteristic lesions that are... more...

MalaCards: Pemphigus Foliaceus, also known as PF, is related to pemphigus and bullous pemphigoid, and has symptoms including positive nikolski's sign/achantolysis An important gene associated with Pemphigus Foliaceus is DSG1 (desmoglein 1), and among its related pathways are Primary immunodeficiency and Rheumatoid arthritis. The compounds blys and mannan have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are renal/urinary system and integument.

Aliases & Classifications for Pemphigus Foliaceus

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Sources:
42NIH Rare Diseases, 44Novoseek, 48Orphanet, 30LifeMap Discovery™, 60UMLS, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

pemphigus foliaceus 42 44 48 30 60
pf 42


External Ids:

ICD10 via Orphanet26 L10.2
SNOMED-CT via Orphanet57 35154004
UMLS via Orphanet61 C0263313
ICD1025 L10.2

Related Diseases for Pemphigus Foliaceus

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17GeneCards, 18GeneDecks
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Diseases related to Pemphigus Foliaceus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 196)
idRelated DiseaseScoreTop Affiliating Genes
1pemphigus32.2DST, PPL, DSG4, DSG3, DSG1, DSG2
2bullous pemphigoid31.0PPL, DST, EVPL
3dermatitis30.8DSG1, CD79A, DSG3, IVL, CTLA4
4psoriasis30.7CD40, IVL, IL4R, HLA-DRB1, CTLA4, DST
5myasthenia gravis30.7TNFSF13B, CTLA4
6thymoma30.6CTLA4, PPL, EVPL
7squamous cell carcinoma30.5IVL, CTLA4, PPL, PLAUR, IL4R, DSG3
8lupus erythematosus30.4CD79A
9impetigo30.4DSG4
10systemic lupus erythematosus30.4TNFSF13B
11dermatomyositis30.4CD40
12hepatitis30.4CTLA4
13lichen planus30.4IVL, DSG3, DST
14arthritis30.4HLA-DRB1, CTLA4
15sarcoma30.4PPL, DSG1, IL4R, EVPL
16skin disease30.4CD79A, IVL, DSG3, DST, DSG1, CD40
17rheumatoid arthritis30.4PRSS2, HLA-DRB1, CD40, CD79A, CD19, CTLA4
18malaria30.2HLA-DRB1
19keratosis30.2IVL
20dermatitis herpetiformis30.2CD79A
21silicosis30.2DSG1
22glomerulonephritis30.2CD79A, MBL2
23tetanus30.2CD79A, CD40
24atopic dermatitis30.1IL4R, CTLA4, IVL, CD40
25graves' disease30.1CTLA4, HLA-DRB1, IL4R, CD40
26chronic lymphocytic leukemia30.1CTLA4, CD19, TNFSF13B, CD40
27connective tissue disease30.1CTLA4, CD19, CD40, HLA-DRB1, CD79A
28hepatitis c30.1CTLA4, TNFSF13B, HLA-DRB1
29leukemia30.1HLA-DRB1, MBL2, CD40, CD19, CD79A, IVL
30lung cancer30.1IVL, CD40, IL4R, PLAUR
31colorectal cancer29.8PRSS2, MASP2, CD40, IL4R, PLAUR
32melanoma29.8CTLA4, PLAUR, IL4R, HLA-DRB1, CD40, DSG1
33alopecia10.4
34pemphigus and fogo selvagem10.4
35acanthosis nigricans10.3
36kaposi's sarcoma10.3
37porokeratosis10.3
38alopecia areata10.3
39contact dermatitis10.3
40hodgkin's lymphoma10.3
41pulmonary fibrosis, familial10.2
42strongyloidiasis10.1
43limited scleroderma10.1
44diffuse scleroderma10.1
45neuromyelitis optica10.1
46subserous uterine fibroid10.1
47folliculitis10.1
48multinodular goiter10.1
49cellulitis10.1
50mixed connective tissue disease10.1

Graphical network of the top 20 diseases related to Pemphigus Foliaceus:



Diseases related to pemphigus foliaceus

Clinical Features for Pemphigus Foliaceus

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Sources:
48Orphanet
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Symptoms:

48
  • positive nikolski's sign/achantolysis

Drugs & Therapeutics for Pemphigus Foliaceus

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pemphigus Foliaceus

Drug clinical trials:

Search ClinicalTrials for Pemphigus Foliaceus

Search NIH Clinical Center for Pemphigus Foliaceus

Search CenterWatch for Pemphigus Foliaceus

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Pemphigus Foliaceus cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pemphigus Foliaceus:
Hematopoietic stem cells for pemphigus

Genetic Tests for Pemphigus Foliaceus

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Anatomical Context for Pemphigus Foliaceus

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32MalaCards
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MalaCards organs/tissues related to Pemphigus Foliaceus:

32
Skin

Animal Models for Pemphigus Foliaceus or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pemphigus Foliaceus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.0PLAUR, DST
2MP:00107719.6CTLA4, DSG4, DSG3, DST, CD19, IL4R
3MP:00053849.4CTLA4, DSG3, DSG2, CD40, CD19, CD79A
4MP:00053769.3DST, DSG4, CTLA4, MBL2, MASP2, CD40
5MP:00053979.3PLAUR, MBL2, TNFSF13B, CTLA4, DSG4, DSG3
6MP:00053879.2DSG4, CTLA4, TNFSF13B, MBL2, DSG3, MASP2

Publications for Pemphigus Foliaceus

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Genetic Variations for Pemphigus Foliaceus

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Expression for genes affiliated with Pemphigus Foliaceus

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pemphigus Foliaceus

Search GEO for disease gene expression data for Pemphigus Foliaceus.

Pathways for genes affiliated with Pemphigus Foliaceus

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Sources:
29KEGG, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN
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Pathways related to Pemphigus Foliaceus according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3CD79A, CD19
210.2TNFSF13B, CTLA4
3
Hide members
10.2MBL2, MASP2
410.2DSG2, DSG1, DSG3
5
Hide members
10.2DSG3, DSG1, DSG2
610.2EVPL, DST, PPL
710.1HLA-DRB1, CD19, IL4R
8
Hide members
10.1CD19, CD40, MASP2
9
Hide members
10.1PLAUR, MASP2, MBL2
1010.0MBL2, HLA-DRB1, DSG1, MASP2
11
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10.0IL4R, CD79A, CD19, HLA-DRB1
12
Hide members
9.9TNFSF13B, CTLA4, HLA-DRB1, CD40, IL4R
13
Hide members
9.4CD79A, UBE2S, MBL2, CTLA4, HLA-DRB1, PRSS2

Compounds for genes affiliated with Pemphigus Foliaceus

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience
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Compounds related to Pemphigus Foliaceus according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1blys4410.5CD79A, CD40, TNFSF13B
2mannan4410.5CD79A, MASP2, MBL2
3con a4410.5MBL2, CTLA4, CD79A
4pimonidazole4410.5IVL, PLAUR
5toxin a4410.5DSG3, DSG1
6mycophenolate mofetil44 49 1112.5CD79A, CD40, CTLA4
7ivig4410.4DSG3, DSG1, CD40, CD79A
8bcma4410.4CD40, TNFSF13B
9neopterin4410.4MBL2, CD40, CD79A, PLAUR
10il 104410.4IL4R, CD40, CTLA4
11p0034410.4IL4R
12suramin44 28 1112.4IVL, PLAUR
13rantes4410.4IL4R, CD40, MBL2
14mannose4410.3MBL2, MASP2, CD40, CD79A
15prednisolone44 28 1112.3MBL2, DSG3, CD40, CD79A
16rituximab44 49 1112.3TNFSF13B, CTLA4, DSG1, CD40, CD79A
17serine4410.3CTLA4, IVL, DSG3, DSG1, MASP2
18methotrexate44 49 1112.3CTLA4, HLA-DRB1, IVL, CD40, CD79A
19fibrinogen4410.3MBL2, MASP2, CD40, CD79A, PLAUR
20vitamin d4410.2MBL2, CTLA4, IVL, CD79A, PLAUR
2112-o-tetradecanoylphorbol 13-acetate4410.2PLAUR, CD40, DST, IVL
22paraffin4410.2MBL2, IVL, DST, CD40, CD79A, PLAUR
23creatinine4410.2MBL2, TNFSF13B, CD40, CD79A, PLAUR
24acetylcholine44 49 28 11 2414.2CD79A, DSG1, DSG3, CTLA4
25cyclosporin a44 28 5912.2CTLA4, IVL, CD40, CD79A, IL4R
26allergens4410.2CTLA4, HLA-DRB1, IVL, CD40, CD79A, IL4R
27biotin44 11 2412.2CD40, CD79A, PLAUR
28tuberculin4410.1CD79A, MBL2
29alanine4410.1TNFSF13B, CTLA4, HLA-DRB1, MASP2, CD79A, PLAUR
30thymidine44 2411.1TNFSF13B, CTLA4, IVL, CD40, IL4R, PLAUR
31phosphatidylinositol4410.0CTLA4, IVL, CD40, CD19, IL4R, PLAUR
32steroid4410.0MBL2, CTLA4, IVL, CD40, CD79A, IL4R
33dexamethasone44 49 28 1113.0MBL2, CTLA4, IVL, CD40, CD79A, IL4R
34cysteine4410.0MBL2, CTLA4, PRSS2, IVL, CD40, CD79A
35cholesterol44 28 11 2413.0MBL2, CTLA4, IVL, CD40, PLAUR
36glatiramer acetate44 1111.0HLA-DRB1, CTLA4
37oligonucleotide449.9IVL, DST, CD40, PLAUR, HLA-DRB1
38lipid449.9MBL2, CTLA4, PPL, IVL, CD40, CD19
39tyrosine449.7MBL2, CTLA4, HLA-DRB1, IVL, DSG3, DSG2
40calcium44 49 11 2412.2PLAUR, MBL2, TNFSF13B, CTLA4, PRSS2, IVL

GO Terms for genes affiliated with Pemphigus Foliaceus

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16Gene Ontology
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Cellular components related to Pemphigus Foliaceus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.8CTLA4, HLA-DRB1, CD40, CD19, CD79A
2desmosomeGO:0300579.8EVPL, DSG2, DSG1, DSG3, DSG4, PPL
3integral to plasma membraneGO:0058879.8HLA-DRB1, CD40, CD19, IL4R, PLAUR, CTLA4
4plasma membraneGO:0058868.8TNFSF13B, CTLA4, PPL, HLA-DRB1, DSG4, DSG3

Biological processes related to Pemphigus Foliaceus according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1B cell receptor signaling pathwayGO:05085310.4CD79A, CD19, CTLA4
2cellular component disassembly involved in execution phase of apoptosisGO:00692110.3DSG2, DSG1, DSG3
3keratinizationGO:03142410.2PPL, IVL, EVPL
4complement activation, lectin pathwayGO:00186710.2MASP2, MBL2
5homophilic cell adhesionGO:00715610.2DSG2, DSG1, DSG3, DSG4
6keratinocyte differentiationGO:03021610.2IVL, DSG4, EVPL
7T cell costimulationGO:03129510.0HLA-DRB1, CTLA4, TNFSF13B
8immune responseGO:00695510.0IL4R, HLA-DRB1, CTLA4, TNFSF13B
9B cell proliferationGO:04210010.0CD40, CD79A

Molecular functions related to Pemphigus Foliaceus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium ion bindingGO:0055099.7MASP2, DSG2, DSG1, DST, DSG3, DSG4

Products for genes affiliated with Pemphigus Foliaceus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pemphigus Foliaceus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet