Pemphigus Foliaceus malady

Wikipedia: Pemphigus foliaceus is an autoimmune blistering disease of the skin and mucous membranes with...⁴⁴ more...

MalaCards: Pemphigus Foliaceus, also known as PF, is related to bullous pemphigoid and keratosis. An important gene associated with Pemphigus Foliaceus is DSG1 (desmoglein 1), and among its related pathways are Graft-versus-host disease and RAR-Gamma-RXR-Alpha Degradation. The compounds ionomycin and hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and b cells, and related mouse phenotypes are renal/urinary system and endocrine/exocrine gland.

pemphigus foliaceus 30 32 43 pf 30

Diseases related to pemphigus foliaceus by text searches and GeneDecks gene sharing:

(show top 50)    (show all 805)

id	Related Disease	Score	Top Affiliating Genes
1	bullous pemphigoid	30.8	CD79A, IVL, EVPL, HLA-DQB1, TNFSF13B, PPL
2	keratosis	29.7	IVL, FAS, TP53, DSG1, DSG2, DSP
3	pemphigus vulgaris	28.8	CD79A, IVL, IL10, IL1A, IL1B, IL1RN
4	malaria	28.6	CD40LG, IL10, IL1A, IL4R, TNF
5	pulmonary tuberculosis	28.5	IL10, MBL2, HLA-DQB1, HLA-DRB1
6	rheumatoid arthritis	28.3	IL1RN, MBL2, HLA-DRB1, CRP, LTA
7	mixed connective tissue disease	27.9	CD40LG, IL6, HLA-DRB1, TRB@, TNF, CRP
8	iga glomerulonephritis	27.7	CD79A, CD40LG, IL6, MBL2, ACE
9	hepatitis b	27.5	CD40, IL10, MBL2, HLA-DQB1, HLA-DRB1, TRB@
10	polycythemia vera	27.5	CD79A, IL6, CRP, ACE
11	echinococcosis	27.4	CD79A, IL10, HLA-DQB1, HLA-DRB1, TNF
12	polycythemia	27.3	CD79A, IL6, FAS, CRP, PLAUR, ACE
13	asthma	27.2	IL1B, IL4R, TNF, CTLA4, LTA
14	myelofibrosis	27.2	CD79A, CD40LG, TP53, TNF, PLAUR
15	peripheral vascular disease	27.1	CD79A, IL6, TP53, CRP, ACE
16	arteriosclerosis	27.1	CD40, IL10, IL6, CRP, ACE
17	atopic dermatitis	27.0	CD40, IVL, IL10, IL1A, IL4R, TNF
18	endocarditis	27.0	CD40LG, IL1A, MBL2, TNF, CRP
19	thrombocytopenia	27.0	CD79A, CD40LG, CD19, IL10, IL1A, IL1B
20	thrombocytosis	27.0	CD79A, CD40LG, IL1A, IL1B, IL6, CRP
21	myxoma	26.8	IL6, FAS, TNF, CRP
22	tuberculosis	26.8	IL10, IL1B, IL1RN, MBL2, TNF
23	cerebral malaria	26.7	IL10, IL1A, IL1B, IL1RN, TNF
24	antiphospholipid syndrome	26.6	CD79A, CD40LG, MBL2, MAPK14, HLA-DQB1, HLA-DRB1
25	arthritis	26.6	IL1A, IL1B, IL6, TNF, PLAUR
26	sickle cell anemia	26.6	CD79A, CD40LG, IL4R, MBL2, HLA-DQB1, HLA-DRB1
27	pemphigus	26.6	UBE2S, BAX, CD79A, CD40LG, CD19, CD40
28	cystic fibrosis lung disease	26.4	IL10, IL1A, IL1B, IL1RN, MBL2, TNF
29	disseminated intravascular coagulation	26.3	CD40LG, IL10, IL1B, IL6, TNF, CRP
30	type 1 diabetes mellitus	26.3	CD79A, IL1B, MAPK14, HLA-DQB1, HLA-DRB1, TRB@
31	eczema	26.1	CD79A, CD40LG, IL10, IL4R, IL6, TNF
32	proliferative diabetic retinopathy	25.9	IL10, IL6, HLA-DQB1, HLA-DRB1, TNF, LTA
33	headache	25.9	CD40LG, IL1B, IL1RN, IL6, TNF, ACE
34	sepsis	25.8	IL10, TNF, LTA
35	spinal cord injury	25.7	IL10, IL1B, IL6, TNF, CRP, LTA
36	fibromyalgia	25.7	IL10, IL1B, IL6, TNF
37	allergic asthma	25.5	IL10, IL4R, CTLA4, LTA
38	urticaria	25.5	CD79A, CD40LG, IL10, IL1A, HLA-DQB1, HLA-DRB1
39	hemophilia	25.4	CD40LG, IL10, IL1B, IL6, HLA-DQB1, HLA-DRB1
40	sickle cell disease	25.3	IL1B, IL6, MBL2, HLA-DQB1, HLA-DRB1, TNF
41	sleep apnea	25.0	CD79A, CD40LG, IL10, IL1B, IL6, TNF
42	pertussis	24.8	CD79A, CD40LG, IL10, IL1A, IL1B, IL6
43	apnea	24.7	BAX, CD79A, CD40LG, IL10, IL1B, IL6
44	hepatitis c	24.6	CD40LG, IL10, FAS, HLA-DRB1, TNF, TNFSF13B
45	connective tissue disease	24.5	CD79A, CD40LG, CD19, CD40, IL10, IL1A
46	hypercholesterolemia	24.5	CD79A, CD40LG, CD40, IL10, IL1B, IL1RN
47	ischemic heart disease	24.5	CD79A, IL1B, IL1RN, IL6, MBL2, MAPK14
48	uremia	24.4	IL10, IL1B, IL6, FAS, TP53, TNF
49	synovitis	24.4	CD40LG, IL1A, IL1B, IL1RN, IL6, FAS
50	schistosomiasis	24.2	CD79A, CD40LG, IL10, IL1A, FAS, MAPK14

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to pemphigus foliaceus:

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MGI Mouse Phenotypes related to pemphigus foliaceus:

²⁵ (show all 16)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	10.3	DST, BAX
2	endocrine/exocrine gland phenotype	MP:0005379	9.7	CD40LG, CTLA4, LTA, DSG4
3	digestive/alimentary phenotype	MP:0005381	9.7	DSG3, DST, CTLA4, TRB@, CD19
4	hematopoietic system phenotype	MP:0005397	9.3	DST, DSG4, DSG3, TNFSF13B, TRB@, HLA-DQB1
5	nervous system phenotype	MP:0003631	9.1	TRB@, HLA-DQB1, CD19, PLAUR, LTA, BAX
6	liver/biliary system phenotype	MP:0005370	8.6	TP53, TRB@, IL6, CD19, CTLA4
7	normal phenotype	MP:0002873	8.5	PPL, CD19, CD40, IVL, CTLA4, TRB@
8	integument phenotype	MP:0010771	8.1	DST, DSP, DSG4, DSG3, TP53, CTLA4
9	skeleton phenotype	MP:0005390	7.5	MAPK14, BAX, FAS, IL6, TP53, CTLA4
10	immune system phenotype	MP:0005387	7.3	CD79A, MBL2, MASP2, HLA-DQB1, TRB@, TP53
11	mortality/aging	MP:0010768	6.4	TRB@, HLA-DQB1, ACE, DSP, DST, DSG4
12	growth/size phenotype	MP:0005378	6.3	IL4R, CD19, BAX, DST, ACE, IL6
13	tumorigenesis	MP:0002006	5.9	TRB@, FAS, TP53, IL1B, IL1A, ACE
14	homeostasis/metabolism phenotype	MP:0005376	5.7	CD19, HLA-DQB1, CTLA4, CRP, PLAUR, LTA
15	cardiovascular system phenotype	MP:0005385	4.6	IL10, IL1RN, CD19, LTA, PLAUR, CRP
16	cellular phenotype	MP:0005384	4.0	FAS, BAX, TNF, TNFSF13B, CTLA4, PLAUR

Articles related to pemphigus foliaceus:

(show top 50)    (show all 84)

id	Title	Authors	Year	Affiliating Genes
1	Canine pemphigus foliaceus antigen is localized within desmosomes of keratinocyte. (18976819)	Yabuzoe A.... Iwasaki T.	2009	DSG1
2	In situ detection of inflammatory cytokines and apoptosis in pemphigus foliaceus patients. (19123745)	Rodrigues D.B.... Rodrigues V.	2009	FAS
3	Tunisian endemic pemphigus foliaceus is associated wi th the HLA-DR3 gene: anti-desmoglein 1 antibody-positive healthy subjects bear protective alleles. (19486004)	Abida O.... Masmoudi H.	2009	HLA-DQB1, HLA-DRB1
4	Individual and epistatic effects of genetic polymorphisms of B-cell co-stimulatory molecules on susceptibility to pemphigus foliaceus. (19421221)	Malheiros D.... Petzl-Erler M.L.	2009	CD19, CD40LG, CD40
5	Antigen selection of anti-DSG1 autoantibodies during and before the onset of endemic pemphigus foliaceus. (19571823)	Qian Y.... Diaz L.A.	2009	DSG1
6	Anti-desmoglein 1 antibodies in healthy related and u nrelated subjects and patients with pemphigus foliaceus in endemic and non-ende mic areas from Tunisia. (19453789)	Abida O.... Makni S.	2009	DSG1
7	The IgM anti-desmoglein 1 response distinguishes Brazilian pemphigus foliaceus (fogo selvagem) from other forms of pemphigus. (17960181)	Diaz L.A.... Rivitti E.A.	2008	DSG1
8	Isolation of pathogenic monoclonal anti-desmoglein 1 human antibodies by phage display of pemphigus foliaceus autoantibodies. (18007588)	Ishii K.... Stanley J.R.	2008	DSG1
9	Advances in pemphigus and its endemic pemphigus foliaceus (Fogo Selvagem) phenotype: a paradigm of human autoimmunity. (18838249)	Culton D.A.... Diaz L.A.	2008	DSG1, DSG3
10	Circulating levels of mannan-binding lectin (MBL) and MBL-associated serine protease 2 in endemic pemphigus foliaceus. (18498410)	Messias-Reason I.... Jensenius J.C.	2008	MASP2, MBL2, PRSS2
11	Coexistence of IgA antibodies to desmogleins 1 and 3 in pemphigus vulgaris, pemphigus foliaceus and paraneoplastic pemphigus. (17263817)	Mentink L.F.... Pas H.H.	2007	CD79A, DSG1, DSG3
12	Generalized erythrodermic pemphigus foliaceus in a ch ild and its successful response to rituximab treatment. (17461818)	Connelly E.A.... Schachner L.A.	2007	DSG1
13	A truncated alternative spliced isoform of human desmoglein 1 contains a specific T cell epitope binding to the pemphigus foliaceus-associated HLA class II DRbeta1*0102 molecule. (17056584)	Mouquet H.... Gilbert D.	2006	HLA-DRB1, DSG1, DSG3
14	Desmoglein-1 is a minor autoantigen in dogs with pemphigus foliaceus. (16293316)	Olivry T.... Dean G.A.	2006	DSG1
15	Wolfgang Bargmann-Preis 2006. Pemphigus foliaceus igG causes dissociation of desmoglein 1-containing junctions without blocking desm oglein 1 transinteraction. (17140142)	Waschke J.... Drenckhahn D.	2006	DSG1
16	Three cases of transition from pemphigus vulgaris to pemphigus foliaceus confirmed by desmoglein ELISA. (15942219)	Ng P.P.... Thng S.T.	2005	DSG3
17	Cytokine gene polymorphisms in endemic pemphigus foliaceus: a possible role for IL6 variants. (15566952)	Pereira N.F.... Petzl-Erler M.L.	2004	IL6, IL1B, IL1A
18	Polymorphisms within the tumor necrosis factor and lymphotoxin-alpha genes and endemic pemphigus foliaceus--are there any associations? (14617046)	Roxo V.M.... Petzl-Erler M.L.	2003	TNF, LTA
19	Pathogenicity and epitope characteristics of anti-desmoglein-1 from pemphigus foliaceus patients expressing only IgG1 autoantibodies. (14675185)	Hacker-Foegen M.K.... Lin M.S.	2003	DSG1
20	Comparative study of autoantigen profile between Colombian and Brazilian types of endemic pemphigus foliaceus by various biochemical and molecular biological techniques. (12788527)	Hisamatsu Y.... Hashimoto T.	2003	DSG1, PPL, EVPL
21	230-kDa and 190-kDa proteins in addition to desmoglein 1 as immunological targets in a subset of pemphigus foliaceus with a combined cell-surface and basement membrane zone immune staining pattern. (14705806)	Karlhofer F.M.... Stingl G.	2003	PPL, DST
22	The plant lectin wheat germ agglutinin inhibits the binding of pemphigus foliaceus autoantibodies to desmoglein 1 in a majority of patients and prevents pathomechanisms of pemphigus foliaceus in vitro and in vivo. (14634141)	Ortiz-Urda S.... Rappersberger K.	2003	DSG1
23	Dissecting the associations of endemic pemphigus foliaceus (Fogo Selvagem) with HLA-DRB1 alleles and genotypes. (12618858)	Pavoni D.P.... Petzl-Erler M.L.	2003	HLA-DRB1
24	Influence of IVIg therapy on autoantibody titers to desmoglein 1 in patients with pemphigus foliaceus. (12482393)	Sami N.... Ahmed A.R.	2002	DSG1
25	T cell receptor Beta chain gene usage in endemic pemphigus foliaceus (fogo selvagem). (12190860)	Moesta A.K.... Sinha A.A.	2002	DSG1, TRB@
26	Pemphigus foliaceus presenting as eruptive seborrheic keratosis and responding to oral gold treatment. (12851996)	Bagheri M.M.... Eiler D.B.	2002	DSG1
27	The transition of pemphigus vulgaris into pemphigus foliaceus: a reflection of changing desmoglein 1 and 3 autoantibody levels in pemphigus vulgaris. (11966706)	Harman K.E.... Black M.M.	2002	DSG1, DSG3
28	A subset of pemphigus foliaceus patients exhibits pathogenic autoantibodies against both desmoglein-1 and desmoglein-3. (11982757)	Arteaga L.A.... Lin M.S.	2002	DSG1, DSG3
29	Desmoglein-1-specific T lymphocytes from patients with endemic pemphigus foliaceus (fogo selvagem). (10642599)	Lin M.S.... Diaz L.A.	2000	DSG1
30	Envoplakin and periplakin, the paraneoplastic pemphigus antigens, are also recognized by pemphigus foliaceus autoantibodies. (10951291)	Kazerounian S.... Aho S.	2000	PPL, EVPL
31	An experience for ELISA for desmoglein 1, suggesting a possible diagnostic help to determine the initial therapy for pemphigus foliaceus. (10694292)	Aoyama Y.... Kitajima Y.	2000	DSG1
32	Human desmocollin 1a transiently expressed in COS-7 cells and NIH 3T3-3 cells is reacted by IgG4 antibodies in a pemphigus foliaceus serum. (10468191)	Dmochowski M.... Hashimoto T.	1999	CD79A
33	Severe nonendemic pemphigus foliaceus presenting in t he postpartum period. (10321632)	Nousari H.C.... Anhalt G.J.	1999	DSG1
34	Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris. (10021453)	Mahoney M.G.... Stanley J.R.	1999	DSG1, DSG3
35	Lack of mucosal involvement in pemphigus foliaceus may be due to low expression of desmoglein 1. (9424092)	Shirakata Y.... Hashimoto K.	1998	DSG1, DSG3
36	Identification of a new antibody population directed against a desmosomal plaque antigen in pemphigus vulgaris and pemphigus foliaceus. (9077476)	Joly P.... Tron F.	1997	DSG1
37	Autoantibody formation against a 190-kDa antigen of the desmosomal plaque in pemphigus foliaceus. (9415240)	Ghohestani R.... Tron F.	1997	DSG1
38	An epitope in the third hypervariable region of the DRB1 gene is involved in the susceptibility to endemic pemphigus foliaceus (fogo selvagem) in three different Brazilian populations. (9027963)	Moraes M.E.... Moraes J.R.	1997	HLA-DRB1
39	D-penicillamine-induced pemphigus foliaceus with autoantibodies to desmoglein-1 in a patient with mixed connective tissue disease. (9216536)	PeA+as P.F.... Diaz L.A.	1997	DSG1
40	Pemphigus foliaceus and pemphigus vulgaris autoantibodies react with the extracellular domain of desmoglein-1. (7860995)	Emery D.J.... Giudice G.J.	1995	DSG1
41	Immunofluorescence and immunoblot studies on the reactivity of pemphigus vulgaris and pemphigus foliaceus sera with desmoglein 3 and desmoglein 1. (8688919)	Hashimoto T.... Nishikawa T.	1995	DSG1, DSG3
42	Tests of inflammatory activity in endemic pemphigus foliaceus (8008917)	Franquini JA_nior J.... Rodrigues JA_nior V.	1994	CRP
43	Structure of DSG1, the bovine desmosomal cadherin gene encoding the pemphigus foliaceus antigen. Evidence of polymorphism. (8294446)	Puttagunta S.... Cowin P.	1994	DSG1
44	Pemphigus foliaceus sera recognize an N-terminal fragment of bovine desmoglein 1. (8006451)	Olague-Alcala M.... Diaz L.A.	1994	DSG1
45	Subclass reactivity of pemphigus foliaceus autoantibodies with recombinant human desmoglein. (8491991)	Allen E.M.... Diaz L.A.	1993	DSG1
46	cDNA cloning of a novel human ubiquitin carrier protein. An antigenic domain specifically recognized by endemic pemphigus foliaceus autoantibodies is encoded in a secondary reading frame of this human epidermal transcript. (1379239)	Liu Z.... Giudice G.J.	1992	UBE2S
47	Ultrastructural study of pemphigus foliaceus and pemphigus vulgaris antigens. Apropos of 2 cases (1724140)	Bedane C.... Bonnetblanc J.M.	1991	DSG3
48	Coexistence of pemphigus foliaceus and bullous pemphigoid. Demonstration of autoantibodies that bind to both the pemphigus foliaceus antigen complex and the bullous pemphigoid antigen. (1998370)	Korman N.J.... Woodley D.T.	1991	DST
49	The calcium-sensitive epitope of pemphigus foliaceus antigen is present on a murine tryptic fragment and constitutes a major antigen ic region for human autoantibodies. (1702818)	Labib R.S.... Anhalt G.J.	1991	DSG1
50	Immunoblot analyses of Brazilian pemphigus foliaceus antigen using different antigen sources. (1693841)	Ogawa M.M.... Nishikawa T.	1990	DSG1

Genes related to pemphigus foliaceus according to GeneCards:

(show all 37)

id	Symbol	Description	Score	GeneCards Section Context
1	DSG1	desmoglein 1	11.1	Functions, Publications, Aliases & Descriptions, Summaries
2	DSG3	desmoglein 3	11.0	Publications
3	EVPL	envoplakin	11.0	Publications
4	PPL	periplakin	11.0	Publications
5	DSG2	desmoglein 2	11.0
6	DST	dystonin	11.0	Publications
7	IVL	involucrin	11.0
8	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications
9	PLAUR	plasminogen activator, urokinase receptor	11.0
10	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
11	PRSS2	protease, serine, 2 (trypsin 2)	11.0	Publications
12	DSG4	desmoglein 4	11.0	Publications
13	MASP2	mannan-binding lectin serine peptidase 2	11.0	Publications
14	UBE2S	ubiquitin-conjugating enzyme E2S	11.0	Publications
15	CD19	CD19 molecule	11.0	Publications
16	TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b	11.0	Publications
17	LTA	lymphotoxin alpha (TNF superfamily, member 1)	11.0	Publications
18	DSP	desmoplakin	11.0	Publications
19	IL4R	interleukin 4 receptor	11.0	Publications
20	CD40	CD40 molecule, TNF receptor superfamily member 5	11.0	Publications
21	MBL2	mannose-binding lectin (protein C) 2, soluble	11.0	Publications
22	CTLA4	cytotoxic T-lymphocyte-associated protein 4	11.0	Publications
23	CD40LG	CD40 ligand	11.0	Publications
24	BAX	BCL2-associated X protein	11.0	Publications
25	TRB@	T cell receptor beta locus	11.0	Publications
26	FAS	Fas (TNF receptor superfamily, member 6)	11.0	Publications
27	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
28	IL1A	interleukin 1, alpha	11.0	Publications
29	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	11.0	Publications
30	CRP	C-reactive protein, pentraxin-related	11.0	Publications
31	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
32	IL10	interleukin 10	11.0	Publications
33	IL1B	interleukin 1, beta	11.0	Publications
34	MAPK14	mitogen-activated protein kinase 14	11.0	Publications
35	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
36	TP53	tumor protein p53	11.0	Publications
37	TNF	tumor necrosis factor	11.0	Publications

Pathways related to pemphigus foliaceus according to GeneDecks:

(show top 50)    (show all 90)

id	Pathway	Score	Top Affiliating Genes
1	Graft-versus-host disease20	10.6	IL1A
2	RAR-Gamma-RXR-Alpha Degradation36	10.0	LTA, TNFSF13B, MAPK14
3	IL-6 Pathway36	10.0	IL10, TNFSF13B, BAX
4	NFAT Signaling and Lymphocyte Interactions36	9.8	BAX, TNFSF13B, IL1A
5	Immune System38	9.6	CTLA4, CD79A, CD40
6	Staphylococcus aureus infection20	9.5	HLA-DQB1, MASP2, DSG1, MBL2, IL10, HLA-DRB1
7	Apoptosis38	9.4	TNF, DSP, DSG2, DSG1, FAS, BAX
8	THC Differentiation Pathway36	9.2	HLA-DQB1, HLA-DRB1, TNF, IL4R, IL10
9	Autoimmune thyroid disease20	9.1	CD40LG, CD40, HLA-DQB1, HLA-DRB1, CTLA4, FAS
10	Asthma20	9.1	HLA-DRB1, IL10, CD40, HLA-DQB1, CD40LG, TNF
11	PGC1Alpha Pathway36	9.0	MAPK14, BAX, TNFSF13B, IL1A, IL1B, IL4R
12	Endothelin-1 Signaling Pathway36	8.9	TNFSF13B, IL10, IL1A, IL1B, IL6
13	Allograft rejection20	8.8	CD40LG, CD40, FAS, HLA-DRB1, HLA-DQB1, IL10
14	Intestinal immune network for IgA production20	8.8	IL6, TNFSF13B, IL10, HLA-DRB1, HLA-DQB1, CD40LG
15	Regulation of eIF4 and p70S6K36	8.8	BAX, IL1A, TNFSF13B, IL6, MAPK14
16	Type I diabetes mellitus20	8.7	IL1A, TNF, HLA-DQB1, FAS, LTA, HLA-DRB1
17	Akt Signaling36	8.7	TNFSF13B, IL6, IL10, IL4R, TNF, LTA
18	Systemic lupus erythematosus20	8.7	CD40, CD40LG, TNF, HLA-DRB1, IL10, HLA-DQB1
19	TRAF Pathway36	8.6	LTA, IL1A, IL1B, TNF, TNFSF13B, MAPK14
20	African trypanosomiasis20	8.5	FAS, IL10, IL1B, IL6, TNF
21	Molecular Mechanisms of Cancer36	8.5	IL6, TNFSF13B, BAX, IL4R, TP53, LTA
22	Toxoplasmosis20	8.5	TNF, HLA-DQB1, IL10, CD40LG, HLA-DRB1, MAPK14
23	Hematopoietic cell lineage20	8.5	IL1A, TNF, IL6, HLA-DRB1, IL4R, IL1B
24	Malaria20	8.4	CD40LG, TNF, IL6, IL1B, IL10, CD40
25	Cytokine Network36	8.4	TNF, IL6, IL1B, IL1A, LTA, IL10
26	Leishmaniasis20	8.2	IL1A, HLA-DQB1, IL10, IL1B, MAPK14, HLA-DRB1
27	Rheumatoid arthritis20	8.2	HLA-DRB1, IL1A, IL1B, HLA-DQB1, IL6, CTLA4
28	Apoptosis20	8.1	TP53, TNF, FAS, IL1B, IL1A, BAX
29	Immune response IL-1 signaling pathway10	8.1	MAPK14, IL1B, IL1A, IL6, TNF
30	IL-10 Pathway36	8.0	IL1A, IL1B, IL6, MAPK14, TNF, IL10
31	MIF Regulation of Innate Immune Cells36	8.0	LTA, BAX, IL1B, IL1A, IL6, IL10
32	SUMO Pathway36	8.0	LTA, TP53, IL1A, TNF, MAPK14, IL1B
33	MIF Mediated Glucocorticoid Regulation36	8.0	IL1B, IL1A, TNFSF13B, IL6, TNF, LTA
34	all-trans-Retinoic Acid Signaling in Brain36	8.0	LTA, TNFSF13B, TNF, IL1B, IL1A, IL6
35	PEDF Induced Signaling36	8.0	BAX, TNFSF13B, IL1B, IL6, TNF, LTA
36	Pertussis20	8.0	IL1A, MAPK14, IL6, IL10, IL1B, TNF
37	Immune response_IL-1 signaling pathway41	8.0	IL6, TNF, IL1B, MAPK14, IL1A
38	Glucocorticoid Receptor Signaling36	7.9	IL6, TNFSF13B, MAPK14, IL4R, IL1B, BAX
39	TGF-Beta Pathway36	7.8	IL1A, IL1B, IL4R, IL6, MAPK14, TNFSF13B
40	Immune response_MIF in innate immunity response41	7.8	TNF, IL6, IL1B, MAPK14, TP53
41	Immune response MIF in innate immunity response10	7.7	MAPK14, TP53, TNF, IL1B, IL6
42	PAK Pathway36	7.7	TNF, IL6, IL1B, IL10, TNFSF13B, LTA
43	Chagas disease (American trypanosomiasis)20	7.7	IL6, IL1B, IL10, TNF, ACE, FAS
44	Influenza A20	7.6	HLA-DQB1, TNF, PRSS2, HLA-DRB1, IL1A, IL1B
45	Antioxidant Action of Vitamin-C36	7.6	TNF, IL6, BAX, LTA, TNFSF13B, IL4R
46	Tuberculosis20	7.4	IL6, MAPK14, HLA-DQB1, HLA-DRB1, IL10, IL1A
47	Cytokine-cytokine receptor interaction20	7.4	CD40, FAS, IL4R, IL1B, TNF, IL1A
48	STAT3 Pathway36	7.3	IL1A, BAX, IL1B, IL10, TNFSF13B, TNF
49	MAPK Family Pathway36	7.2	TNFSF13B, MAPK14, LTA, IL6, IL4R, IL1B
50	p38 Signaling36	6.4	MAPK14, TP53, TNF, TNFSF13B, LTA, IL6

Compounds related to pemphigus foliaceus according to GeneDecks:

(show top 50)    (show all 203)

id	Compound	Score	Top Affiliating Genes
1	ionomycin32	10.5	CD40
2	hyaluronic acid32 18	11.4	PLAUR, LTA
3	ivig32	10.2	DSG1, LTA, CRP, DSG3
4	blys32	10.1	CD40, CD79A, CD40LG, TNFSF13B
5	pge232	10.0	IL1RN, IL1A, PLAUR, IVL
6	n acetylcysteine32	9.6	TP53, PLAUR, CD40, CD79A
7	endotoxin32	9.5	LTA, PLAUR, CRP, CD40, MAPK14
8	rituximab32 34 9 9	12.1	CD79A, CD40LG, CD40, IL10, TNFSF13B, CTLA4
9	polyinosinic-polycytidylic acid32	9.0	CD40, IL10, IL6, MAPK14
10	allergens32	8.9	CTLA4, HLA-DRB1, IL4R, IL1RN, IL10, IVL
11	cyclosporin a32 42	9.7	TRB@, IL10, IL1A, CTLA4, LTA, IL4R
12	calcium32 9 18 9	11.7	DSG2, DSG3, DSG4, DSP, DSG1, LTA
13	sb 20358032 42	9.6	IVL, PLAUR, CRP, TNF, MAPK14, IL6
14	toxin-132	8.6	LTA, TNF, IL1B, IL10, IL1RN
15	sulfasalazine32 9 9	10.5	CD79A, IL1A, IL1B, CRP, TNF, IL1RN
16	adalimumab32 9 9	10.4	TNF, IL10, CD79A, CRP, IL1RN, IL6
17	anakinra32 9 9	10.4	TNF, IL1B, IL1RN, CRP, IL6
18	tenidap42 32	9.3	CRP, TNF, IL6, IL1A, IL1B
19	okt332	8.2	CD79A, CD40LG, IL10, CRP, IL6, FAS
20	polymyxin b32	8.0	TNF, MBL2, IL1A, IL10, IL1B, IL1RN
21	tgf beta132	8.0	DSP, LTA, PLAUR, IL6, CTLA4, FAS
22	etanercept32 9 9	10.0	TNF, IL10, IL1B, IL1RN, IL6, LTA
23	groalpha32	8.0	IL1B, TNF, MAPK14, IL1A, IL10
24	rantes32	8.0	LTA, CD40, IL1A, IL4R, IL6, FAS
25	vitamin d32	7.9	LTA, PLAUR, CTLA4, MBL2, FAS, IL6
26	prednisolone32 9 9	9.9	DSG3, LTA, CRP, TNF, MBL2, IL6
27	pentoxifylline32 9 9	9.9	IL6, LTA, TNF, IL1RN, IL10, IL1B
28	lipoteichoic acid32	7.7	LTA, IL10, MBL2, IL1B, TNF, IL1RN
29	ly29400232	7.7	IL6, IL1B, IL10, MAPK14, TNF, CTLA4
30	infliximab32 9 9	9.6	TNF, CRP, IL1B, IL1RN, IL6, FAS
31	hydrocortisone32 9 9	9.6	TNF, CD40, IL6, IL1RN, IL1B, IL1A
32	fibrinogen32	7.5	IL6, PLAUR, IL1RN, CD40, CRP, CD40LG
33	paraffin32	7.5	CD79A, PLAUR, BAX, CD40LG, CD40, IVL
34	il 1032	7.5	LTA, TNF, CD40, IL10, CTLA4, IL1RN
35	triptolide32	7.4	IL1B, BAX, CD40, TNF, TP53, IL6
36	herbimycin a32 42	8.4	CD40LG, IL1B, LTA, IL6, TNF, MAPK14
37	creatinine32	7.4	CRP, MBL2, FAS, TNFSF13B, IL1RN, IL6
38	methotrexate32 34 42 9 9	11.4	IL1B, IL10, IVL, CD40, IL1RN, IL6
39	vegf32	7.1	LTA, PLAUR, CRP, CD40LG, TP53, MAPK14
40	sp 60012532 42	8.0	FAS, TNF, BAX, IL6, CD40, MAPK14
41	indomethacin32 9 9	9.0	MAPK14, TNF, PLAUR, FAS, IL1RN, IL1B
42	curcumin32	7.0	TP53, IVL, BAX, PLAUR, IL1A, TNF
43	neopterin32	6.9	IL6, CD79A, CD40LG, CD40, IL10, IL1A
44	thymidine32 18	7.4	TNFSF13B, IL10, CD40, IL6, IL4R, IL1B
45	tyrosine32	6.4	HLA-DQB1, IL6, CD19, CD40, IVL, IL1RN
46	actinomycin d32	6.2	LTA, PLAUR, CD40, TNF, TP53, MAPK14
47	serine32	5.9	DSG1, DSP, PRSS2, IVL, CD40, FAS
48	dexamethasone32 42 34 9 9	9.9	IL10, IVL, CD40, CD40LG, CD79A, IL1A
49	retinoic acid32 42 18	7.5	IVL, CD79A, IL6, FAS, MAPK14, TP53
50	cycloheximide32	5.3	LTA, PLAUR, CRP, TNF, TP53, MAPK14

Cellular components related to pemphigus foliaceus according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cornified envelope	GO:001533	10.1	IVL, DSP, EVPL
2	desmosome	GO:030057	9.7	PPL, DSG4, DSG3, DSG2, DSG1, EVPL
3	external side of plasma membrane	GO:009897	8.3	CD19, CD79A, CD40LG, CD40, FAS, HLA-DRB1
4	extracellular region	GO:005576	7.0	IL6, IL4R, IL1B, IL1A, CD40, FAS
5	plasma membrane	GO:005886	6.4	PPL, PLAUR, ACE, DSG1, DSG2, DSG3
6	extracellular space	GO:005615	6.2	TNFSF13B, CRP, LTA, ACE, PRSS2, TNF

Biological processes related to pemphigus foliaceus according to GeneDecks:

(show all 41)

id	Name	GO ID	Score	Top Affiliating Genes
1	peptide cross-linking	GO:018149	10.4	IVL, EVPL, DSP
2	cellular component disassembly involved in apoptotic process	GO:006921	10.3	DSG1, DSG2, DSG3, DSP
3	keratinocyte differentiation	GO:030216	10.2	DSP, IVL, EVPL, DSG4
4	B cell receptor signaling pathway	GO:050853	10.2	CD79A, CD19, CTLA4
5	keratinization	GO:031424	10.2	PPL, IL1A, IVL, EVPL
6	chronic inflammatory response to antigenic stimulus	GO:002439	10.2	IL1B, IL1RN
7	positive regulation of chronic inflammatory response to antigenic stimulus	GO:002876	10.1	TNF, LTA
8	positive regulation of B cell apoptotic process	GO:002904	10.0	IL10, BAX
9	regulation of immunoglobulin secretion	GO:051023	9.9	TNF, CD40, CD40LG
10	B cell proliferation	GO:042100	9.9	CD79A, CD40, IL10, CD40LG
11	fever generation	GO:001660	9.9	IL1B, IL1A
12	transformed cell apoptotic process	GO:006927	9.9	FAS, TNF, BAX
13	receptor biosynthetic process	GO:032800	9.7	IL10, TNF
14	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.7	TNF, IL1B
15	response to ozone	GO:010193	9.7	IL1B, IL1A
16	sequestering of triglyceride	GO:030730	9.7	IL1B, TNF
17	negative regulation of growth of symbiont in host	GO:044130	9.6	TNF, IL10, MBL2, LTA
18	negative regulation of fibroblast proliferation	GO:048147	9.6	BAX, LTA, TP53
19	positive regulation of cytokine secretion	GO:050715	9.5	IL1A, TNF, IL10
20	response to organic nitrogen	GO:010243	9.5	IL1A, IL1B, IL1RN
21	positive regulation of interferon-gamma production	GO:032729	9.5	TNF, IL1B, CD40LG, LTA
22	neuron apoptotic process	GO:051402	9.4	TP53, BAX, FAS
23	acute-phase response	GO:006953	9.4	IL1RN, MBL2, CRP, IL6
24	negative regulation of lipid storage	GO:010888	9.4	CRP, IL6, TNF
25	defense response to Gram-positive bacterium	GO:050830	9.3	IL6, MBL2, TNF, LTA
26	positive regulation of mitosis	GO:045840	9.3	TNF, IL1B, IL1A
27	lipopolysaccharide-mediated signaling pathway	GO:031663	9.3	IL1B, TNF, MAPK14
28	response to salt stress	GO:009651	9.2	BAX, TNF, TP53
29	immune response	GO:006955	9.2	HLA-DQB1, TNFSF13B, CTLA4, IL4R, IL1RN, HLA-DRB1
30	positive regulation of heterotypic cell-cell adhesion	GO:034116	9.2	TNF, IL1B
31	response to gamma radiation	GO:010332	9.1	IL1B, TP53, IL1A, BAX
32	positive regulation of interleukin-6 production	GO:032755	9.0	TNF, IL1A, IL1B, IL6
33	response to hypoxia	GO:001666	8.8	LTA, TNF, IL1A, IL1B, FAS, CRP
34	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	8.8	IL10, TNF, IL6, IL1B
35	anti-apoptosis	GO:006916	8.7	IL10, TNF, FAS, IL1B, IL1A, CD40LG
36	cytokine-mediated signaling pathway	GO:019221	8.6	HLA-DQB1, IL6, IL1B, IL1A, HLA-DRB1
37	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.6	IL6, TNF, IL1B, CD40
38	response to glucocorticoid stimulus	GO:051384	8.3	IL1B, IL1RN, IL6, FAS, IL10, TNF
39	positive regulation of apoptotic process	GO:043065	8.3	FAS, TP53, TNF, IL1B, BAX, CTLA4
40	inflammatory response	GO:006954	7.8	TNF, CD40, IL10, IL1A, CD40LG, IL1B
41	apoptotic process	GO:006915	7.2	DSG2, DSG3, DSP, IL1B, DSG1, TNF

Molecular functions related to pemphigus foliaceus according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	tumor necrosis factor receptor binding	GO:005164	9.3	LTA, TNFSF13B, TNF, CD40LG
2	interleukin-1 receptor binding	GO:005149	9.1	IL1RN, IL1B, IL1A
3	cytokine activity	GO:005125	7.6	CD40LG, LTA, TNFSF13B, TNF, IL6, IL1B
4	protein binding	GO:005515	5.2	TNFSF13B, CTLA4, PPL, CRP, PLAUR, ACE