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Pemphigus Vulgaris malady
59 genes, 5 tissues, 862 related diseases, 21 phenotypes, 201 articles, clinical trials.

Summaries for Pemphigus Vulgaris

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30NIH Rare Diseases, 44Wikipedia, 22MalaCards
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NIH Rare Diseases: Pemphigus vulgaris is an autoimmune disorder that involves blistering of the skin and mucous membranes. It occurs almost exclusively in middle-aged or older people. Many cases begin with blisters in the mouth, followed by skin blisters that may come and go. In most cases, the exact cause of pemphigus vulgaris is unknown. It has rarely been observed in multiple members of the same family. Treatment is aimed at reducing symptoms and preventing complications. Severe cases are treated similarly to severe burns.30

MalaCards: Pemphigus Vulgaris is related to hailey-hailey disease and bullous pemphigoid. An important gene associated with Pemphigus Vulgaris is DSG3 (desmoglein 3), and among its related pathways are Antigen processing and presentation and Immune System. The compounds hyaluronic acid and ivig have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and thyroid, and related mouse phenotypes are respiratory system and renal/urinary system.

Wikipedia: Pemphigus vulgaris is a chronic blistering skin disease with skin lesions that are rarely pruritic, but...44 more...

Aliases & Descriptions for Pemphigus Vulgaris

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30NIH Rare Diseases, 32Novoseek , 43UMLS
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pemphigus vulgaris 30 32 43

Related Diseases for Pemphigus Vulgaris

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13GeneCards, 14GeneDecks
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Diseases related to pemphigus vulgaris by text searches and GeneDecks gene sharing:

(show top 50)    (show all 859)
idRelated DiseaseScoreTop Affiliating Genes
1hailey-hailey disease32.3JUP, CDH1, DSG1, DSG3, DSP
2bullous pemphigoid31.8CIITA, CD79A, IL5, IGHE, EVPL, HLA-DQB1
3pemphigus foliaceus31.5CD79A, IL10, IL1A, IL1B, IL1RN, IL4R
4papilloma28.5IL2, IFNG, HLA-B, HLA-G, EGF, DSG3
5silicosis26.9JUP, IL10, IL1A, IL1B, IL1RAPL2, IL1RN
6skin disease25.5CIITA, CD79A, IL10, IL1A, IL4, IL5
7pemphigus25.4CIITA, MTOR, JUP, CD79A, CDK2, CDH1
8gingivitis21.1CD79A, CDH1, MMP9, IL10, IL15, IL1A
9blindness20.8CD79A, MMP9, IL10, IL1A, IL1B, IL1R1
10carcinoma17.5CIITA, MTOR, JUP, CD79A, CDK2, CDH1
11thyroiditis17.5CIITA, MTOR, JUP, CD79A, CDK2, CDH1
12ritter's disease13.8DSG1, DSG3, DSG4
13arrhythmogenic right ventricular dysplasia13.8JUP, DSG2, DSP
14follicular dendritic cell sarcoma13.8EVPL, PPL, DSG1, DSG3, DSP
15dendritic cell sarcoma13.8EVPL, PPL, DSG1, DSG3, DSP
16subcorneal pustular dermatosis13.8CD79A, DSC3, DSG1, DSG3
17tubulointerstitial nephritis and uveitis13.8HLA-DQA1, HLA-DQB1, HLA-DRB1
18keratoacanthoma13.7JUP, DSG1, DSG2, DSG3
19palmoplantar keratosis13.7JUP, DSG1, DSP
20dilated cardiomyopathy with woolly hair and keratoderma13.7JUP, DSP
21breast cancer, lobular13.7JUP, CDH1
22bullous skin disease13.7IL5, EVPL, DSG1, DSG3
23keratoderma13.7JUP, EVPL, DSG1, DSP
24cervical dystonia13.7HLA-DQA1, HLA-DQB1, HLA-DRB1
25impetigo13.7CD79A, DSG1, DSG2, DSG3, DSG4
26herpes gestationis13.6CD79A, RNASE3, DSG1
27intrahepatic cholestasis of pregnancy13.6HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-G
28nonepidermolytic palmoplantar keratoderma13.6EVPL, DSG1, DSP
29celiac disease13.6HLA-DQA1, HLA-DQB1
30follicular adenoma13.6JUP, CDH1, TPO, PLAUR
31leprosy13.6IL10, HLA-DQA1, HLA-DQB1, HLA-DRB1
32whipple disease13.6HLA-B, HLA-DQB1, HLA-DRB1
33immunoglobulin alpha deficiency13.6CD79A, IGHE, HLA-DQB1
34paroxysmal nocturnal hemoglobinuria13.5PLAU, PLAUR, ACHE
35pityriasis rosea13.5HLA-B, HLA-DQB1, HLA-DRB1
36rheumatoid arthritis13.5IL1R1, IL1RN, HLA-DRB1
37contact dermatitis13.5IL1A, IL5, IGHE
38autoimmune hepatitis13.5HLA-DQB1, HLA-DRB1, TPMT, TPO
39idiopathic myopathy13.5IL1A, IL1R1, HLA-B
40pars planitis13.5IL1RN, HLA-B, HLA-DRB1
41helminthiasis13.5IL5, IGHE, RNASE3
42neisseria meningitidis infection13.5IL1R1, IL1RN, C3
43splenomegaly13.5IL10, FASLG, HLA-DQB1, HLA-DRB1
44chronic eosinophilic pneumonia13.5IL10, IL5, RNASE3
45paragonimiasis13.4IL5, IGHE, RNASE3
46eosinophilic pneumonia13.4IL5, IGHE, RNASE3
47paranasal sinus disease13.4IL5, IFNG, PLAU, PLAUR
48cystic echinococcosis13.4IGHE, HLA-B, HLA-DRB1, TAP2
49somatoform disorder13.4IL1A, IL1B, IL1RN
50meningococcemia13.4IL1A, IL1B, IL1RN

Graphical network of the top 20 diseases related to pemphigus vulgaris:



Graphical network of diseases related to pemphigus vulgaris

Clinical Features for Pemphigus Vulgaris

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Drugs & Therapeutics for Pemphigus Vulgaris

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Genetic Tests for Pemphigus Vulgaris

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Anatomical Context for Pemphigus Vulgaris

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22MalaCards
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MalaCards organs/tissues related to pemphigus vulgaris:

22
Skin, Lymph node, Thyroid, T cells, B cells

Phenotypes for genes affiliated with Pemphigus Vulgaris

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25MGI
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MGI Mouse Phenotypes related to pemphigus vulgaris:

25 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1respiratory system phenotypeMP:000538810.3ACHE, PTPN22, IL12A
2renal/urinary system phenotypeMP:000536710.3C3, MTOR
3endocrine/exocrine gland phenotypeMP:00053799.8IFNG, IL2, DSG4, FASLG
4hematopoietic system phenotypeMP:00053979.4IL4R, IL5, IL12RB2, IGHE, HLA-DQA1, HLA-DQB1
5liver/biliary system phenotypeMP:00053709.2PTPN22, C3, IL12RB2, IL1R1, IL2, IL6
6nervous system phenotypeMP:00036318.9TGFB1, PERP, C3, CHRNA9, ACHE, PLAUR
7digestive/alimentary phenotypeMP:00053818.8IFNG, PLAU, EGF, TGFB1, C3, MMP9
8adipose tissue phenotypeMP:00053758.6PLAU, EIF6, ACHE, DSG3, DSG4, TGFB1
9integument phenotypeMP:00107718.5JUP, CDK2, IL1R1, IL4, IL4R, FASLG
10immune system phenotypeMP:00053878.3DSG3, PLAUR, PTPN22, TNF, HLA-DQB1, DSG4
11skeleton phenotypeMP:00053908.1C3, PLAU, MAPK14, IL6, IL1R1, MMP9
12normal phenotypeMP:00028737.7CD79A, IL10, C3, IL4, FASLG, ALB
13mortality/agingMP:00107687.5CAT, IFNG, IL6, IL4R, IL1R1, IL1B
14reproductive system phenotypeMP:00053897.1IFNG, TNF, ACHE, TGFB1, MMP9, FASLG
15growth/size phenotypeMP:00053786.9EIF6, MAPK14, TPMT, TPO, PTPN22, JUP
16vision/eye phenotypeMP:00053916.7TGFB1, MMP9, CDK2, EGF, IL10, IL1R1
17muscle phenotypeMP:00053696.5PLAUR, MAPK14, IFNG, HLA-DQB1, TNF, PLAU
18homeostasis/metabolism phenotypeMP:00053766.0CIITA, MTOR, JUP, CD79A, CDK2, CDH1
19tumorigenesisMP:00020065.9IL1A, CDH1, MMP9, IL12A, IL12RB2, IL1B
20cardiovascular system phenotypeMP:00053855.5IL10, IL12RB2, IL15, IL1B, IL1A, IL1R1
21cellular phenotypeMP:00053844.1JUP, MMP9, CIITA, FASLG, MTOR, PLAU

Publications for genes affiliated with Pemphigus Vulgaris

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35PubMed
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Articles related to pemphigus vulgaris:

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idTitleAuthorsYearAffiliating Genes
1HLA-DRB1*04:02, DRB1*08:04 and DRB1*14 alleles associ ated to pemphigus vulgaris in southeastern Brazilian population. (21554253)Weber R.... Miziara I.D.2011HLA-DRB1
2Binding of pemphigus vulgaris IgG to antigens in desm osome core domains excludes immune complexes rather than directly splitting des mosomes. (20222919)Aoyama Y.... Kitajima Y.2010DSG1
3Prevalence of non-organ-specific autoantibodies in patients with pemphigus vulgaris. (19298776)Blondin D.A.... Mydlarski P.R.2009RNPC3
4Novel therapies for pemphigus vulgaris: an overview. (19761276)Perez O.A.... Patton T.2009DSG3
5Oesophagitis dissecans superficialis: an acute, benig n phenomenon associated with pemphigus vulgaris. (19489862)Cesar W.G.... Santi G.G.2009DSG1
6Pemphigus vulgaris IgG-induced desmoglein-3 endocytosis and desmosomal disassembly are mediated by a clathrin- and dynamin-independent mechanism. (18434319)Delva E.... Kowalczyk A.P.2008DSG3
7Genetic characterization of human Dsg3-specific B cells isolated by flow cytometry from the peripheral blood of patients with pemphigus vulgaris. (18586466)Yamagami J.... Amagai M.2008DSG3
8Serum concentration of interleukin-6 is increased both in active and remission stages of pemphigus vulgaris. (18584045)Narbutt J.... Lesiak A.2008IL6
9Disease progression from mucosal to mucocutaneous involvement in a patient with desquamative gingivitis associated with pemphigus vulgaris. (18251653)Endo H.... Yamamoto H.2008DSG3
10Treatment of refractory pemphigus vulgaris with anti-CD20 monoclonal antibody (rituximab): five cases. (17538808)Antonucci A.... Varotti C.2007DSG1
11Intraperitoneal injection of pemphigus vulgaris-IgG into mouse depletes epidermal keratinocytes of desmoglein 3 associated with generation of acantholysis. (17431647)Shu E.... Kitajima Y.2007DSG3
12IgG autoantibodies directed against desmoglein 3 cause dissociation of keratinocytes in canine pemphigus vulgaris and paraneoplastic pemphigus. (17350107)Nishifuji K.... Amagai M.2007DSG1, DSG3
13Coexistence of IgA antibodies to desmogleins 1 and 3 in pemphigus vulgaris, pemphigus foliaceus and paraneoplastic pemphigus. (17263817)Mentink L.F.... Pas H.H.2007CD79A, DSG1, DSG3
14Searching for experimental models of Pemphigus vulgaris. (17377799)Cirillo N.... Lanza A.2007DSG3
15Desmoglein versus non-desmoglein signaling in pemphigus acantholysis: characterization of novel signaling pathways downstream of pemphigus vulgaris antigens. (17344213)Chernyavsky A.I.... Grando S.A.2007DSG3
16Prediction of desmoglein-3 peptides reveals multiple shared T-cell epitopes in HLA DR4- and DR6-associated pemphigus vulgaris. (17254312)Tong J.C.... Ranganathan S.2006DSG3
17Serum levels of BAFF are increased in bullous pemphigoid but not in pemphigus vulgaris. (16882171)Asashima N.... Tamaki K.2006TNFSF13B
18Protective effect of intravenous immunoglobulin (IVIG ) in an experimental model of pemphigus vulgaris. (16297153)Mimouni D.... Shoenfeld Y.2005DSG3
19Number II. Pemphigus vulgaris. (15888101)Black M.... Scully C.2005DSG1
20Pemphigus vulgaris is associated with the transporter associated with antigen processing (TAP) system. (16690408)Slomov E.... Gazit E.2005TAP2
21In vitro keratinocyte dissociation assay for evaluation of the pathogenicity of anti-desmoglein 3 IgG autoantibodies in pemphigus vulgaris. (15854034)Ishii K.... Amagai M.2005DSG2, DSG1, DSG3
22Life-threatening bullous dermatoses: Pemphigus vulgaris. (15896536)Ruocco E.... Ruocco V.2005DSG3
23Pemphigus vulgaris acantholysis ameliorated by cholinergic agonists. (15023776)Nguyen V.T.... Grando S.A.2004CDH1, ACHE
24Mucosal dominant pemphigus vulgaris with anti-desmoplakin autoantibodies. (15243525)Mimouni D.... Nousari C.H.2004DSP, PPL, EVPL
25Beneficial effects of topical tacrolimus on recalcitr ant erosions of pemphigus vulgaris. (15115509)Gach J.E.... Ilchyshyn A.2004TNF, IFNG
26Serum levels of autoantibodies to desmoglein 3 in pat ients with therapy-resistant pemphigus vulgaris successfully treated with adjuv ant intravenous immunoglobulins. (15040478)Herzog S.... Zillikens D.2004DSG3
27Desmoglein-3 is a target autoantigen in spontaneous canine pemphigus vulgaris. (12702149)Olivry T.... Ghohestani R.F.2003DSG3
28Immunologic and histopathologic characterization of an active disease mouse model for pemphigus vulgaris. (11851895)Ohyama M.... Nishikawa T.2002DSG1
29Strict correlation between uPAR and plakoglobin expression in pemphigus vulgaris. (12358812)Lo Muzio L.... De Rosa G.2002JUP, PLAUR
30Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris. (11857336)Tsunoda K.... Koyasu S.2002DSG3
31Neonatal pemphigus vulgaris with extensive mucocutaneous lesions from a mother with oral pemphigus vulgaris. (12366435)Campo-Voegeli A.... Camps A.2002DSG1, DSG3
32The transition of pemphigus vulgaris into pemphigus foliaceus: a reflection of changing desmoglein 1 and 3 autoantibody levels in pemphigus vulgaris. (11966706)Harman K.E.... Black M.M.2002DSG1, DSG3
33IgG, IgA and IgE autoantibodies against the ectodomain of desmoglein 3 in active pemphigus vulgaris. (11422039)Spaeth S.... Hertl M.2001CD79A, DSG3
34Pemphigus vulgaris with autoantibodies to desmoplakin. (11736914)Kim S.C.... Amagai M.2001DSP
35Antibodies against keratinocyte antigens other than d esmogleins 1 and 3 can induce pemphigus vulgaris-like lesions. (11120754)Nguyen V.T.... Grando S.A.2000DSG1
36The distribution of pemphigus vulgaris-IgG subclasses and their reactivity with desmoglein 3 and 1 in pemphigus patients and their first-degree relatives. (10951142)Kricheli D.... Milner Y.2000DSG3
37Late development of antidesmoglein 1 antibodies in pemphigus vulgaris: correlation with disease progression. (10606856)Miyagawa S.... Shirai T.1999DSG1
38Use of recombinant pemphigus vulgaris antigen in deve lopment of ELISA and IB assays to detect pemphigus vulgaris autoantibodies. (9552754)Bhol K.... Ahmed A.R.1998DSG3
39Recognition of desmoglein 3 by autoreactive T cells in pemphigus vulgaris patients and normals. (9424089)Hertl M.... Katz S.I.1998DSG3
40Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. (9166409)Koch P.J.... Stanley J.R.1997DSG3
41Mucosal and mucocutaneous (generalized) pemphigus vulgaris show distinct autoantibody profiles. (9326396)Ding X.... Fairley J.A.1997DSG3
42T lymphocytes from a subset of patients with pemphigus vulgaris respond to both desmoglein-3 and desmoglein-1. (9406813)Lin M.S.... Diaz L.A.1997DSG1, DSG3
43Identification of different circulating autoantibodies in patients with bullous pemphigoid and pemphigus vulgaris by means of immunoblotting. (8876727)Kiss M.... Dobozy A.1996DSG3
44Pemphigus vulgaris antigen (desmoglein 3) is localized in the lower epidermis, the site of blister formation in patients. (8601740)Amagai M.... Stanley J.R.1996DSG1, DSG3
45Pemphigus foliaceus and pemphigus vulgaris autoantibodies react with the extracellular domain of desmoglein-1. (7860995)Emery D.J.... Giudice G.J.1995DSG1
46A case of pemphigus vulgaris showing reactivity with pemphigus antigens (Dsg1 and Dsg3) and desmocollins. (7706774)Hashimoto T.... Nishikawa T.1995DSG1, DSG3
47Extracellular domain of pemphigus vulgaris antigen (desmoglein 3) mediates weak homophilic adhesion. (7930691)Amagai M.... Stanley J.R.1994CDH1, DSG3
48Plasminogen activation in lesional skin of Pemphigus vulgaris type Neumann. (7682051)Reinartz J.... Kramer M.D.1993PLAU
49Ultrastructural localization of pemphigus vulgaris and pemphigus foliaceus antigens in cultured human squamous carcinoma cells. (1911315)Akiyama M.... Nishikawa T.1991DSG1
50Detection of pemphigus vulgaris antigen on COLO and SCaBER tumor cell lines by the immunoblot technique. (2260885)Mirza N.M.... Ahmed A.R.1990DSG3

Expression for genes affiliated with Pemphigus Vulgaris

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Pemphigus Vulgaris

Pathways for genes affiliated with Pemphigus Vulgaris

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20KEGG, 38Reactome, 36QIAGEN, 37R&D Systems, 10EMD Millipore
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Pathways related to pemphigus vulgaris according to GeneDecks:

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idPathwayScoreTop Affiliating Genes
1Antigen processing and presentation2010.1HLA-G, TAP2, HLA-DQA1, HLA-DRB1, CIITA, HLA-DQB1
2Immune System389.6IL5, TAP2, HLA-G, IFNG, CIITA, CD79A
3Graft-versus-host disease209.6HLA-G, HLA-DQA1, IL1A, IL2, FASLG, HLA-B
4IL-6 Pathway369.6IL5, TNFSF13B, IL4, IL12A, IL10
5Amoebiasis209.3IL12A, IL1R1, IL6, IL1B, HSPB1, TGFB1
6RAR-Gamma-RXR-Alpha Degradation369.3MAPK14, IL12A, IL15, IL2, TNFSF13B
7IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types379.2IL10, IL12A, IL2, FASLG, TNF, TGFB1
8NFAT Signaling and Lymphocyte Interactions369.2IL1A, IL2, IL5, TNFSF13B, IL12A, IL15
9Asthma209.2RNASE3, TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1, IL5
10African trypanosomiasis209.0IFNG, IL10, IL12A, IL1B, FASLG, TNF
11IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types379.0IL1B, IL4, IL5, IL4R, IL6, TGFB1
12Jak-STAT signaling pathway208.8IL12RB2, IL5, IL4R, IL4, IL2, TPO
13Rheumatoid arthritis208.8HLA-DQB1, IFNG, TNF, IL1B, HLA-DQA1, IL1A
14Akt Signaling368.7TNFSF13B, TNF, IL4R, IL2, IL15, IL10
15Immune response IL-22 signaling pathway108.7IL12A, IL2, MAPK14, HLA-DQA1, HLA-DQB1, HLA-DRB1
16Hematopoietic cell lineage208.6TNF, IL4, IL4R, IL1A, IL5, IL6
17Endothelin-1 Signaling Pathway368.5IL1B, TNFSF13B, IL6, IL5, IL4, IL1A
18THC Differentiation Pathway368.5IL12RB2, IL2, IL4, IL4R, IFNG, HLA-DQA1
19Type I diabetes mellitus208.5IL1A, IL1B, IL2, FASLG, IFNG, HLA-B
20Rho Family GTPases368.4IL15, IL10, CDH1, TGFB1, TNFSF13B, IL12A
21Malaria208.4IL10, TNF, IFNG, IL6, IL1B, IL12A
22Molecular Mechanisms of Cancer368.4TNFSF13B, CDK2, CDH1, IL12RB2, IL15, IL1R1
23Autoimmune thyroid disease208.4IL5, IL2, IL4, FASLG, HLA-B, IL10
24Intestinal immune network for IgA production208.3TGFB1, TNFSF13B, HLA-DRB1, HLA-DQB1, HLA-DQA1, IL6
25Toxoplasmosis208.3HLA-DQA1, HLA-DRB1, IL12A, TNF, TGFB1, IL10
26MIF Mediated Glucocorticoid Regulation368.2IL4, IL2, IL6, IL1B, IL1A, IL15
27Pertussis208.2MAPK14, TNF, IL6, IL1B, IL1A, IL12A
28MIF Regulation of Innate Immune Cells368.2TNF, IL6, IL5, IL4, IL2, IL1B
29all-trans-Retinoic Acid Signaling in Brain368.2IL15, TNFSF13B, IL6, IL5, IL4, IL2
30PEDF Induced Signaling368.2IL4, IL5, TNF, IL1B, IL6, IL2
31SOCS Pathway368.1IL1A, IL12A, IL1B, IL4, IL10, IL15
32Influenza A208.1IL1B, HLA-DRB1, TNF, HLA-DQB1, HLA-DQA1, IFNG
33PGC1Alpha Pathway368.0MAPK14, TNFSF13B, IL12A, IL15, IL1A, IL1B
34Cytokine Network368.0IL10, IL12A, IFNG, TNF, IL6, IL5
35Measles208.0IL6, IL1B, CDK2, IL1A, IL2, IL4
36Tec Kinases Signaling368.0IL2, IL4R, IL12RB2, IL12A, IL5, TNFSF13B
37Allograft rejection207.8IL5, FASLG, IFNG, HLA-B, HLA-DQA1, HLA-DQB1
38Regulation of eIF4 and p70S6K367.7IL12A, IL2, IL1A, IL15, IL6, MAPK14
39Tuberculosis207.6TNF, CIITA, IL10, IL12A, IL1A, IL1B
40PAK Pathway367.6IL1B, IL15, IL10, IL12A, TGFB1, TNF
41Leishmaniasis207.6C3, TGFB1, TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1
42Chagas disease (American trypanosomiasis)207.5FASLG, C3, TGFB1, IL10, IL12A, IL1B
43JAK-STAT Pathway367.3IL10, IFNG, IL6, IL5, IL4R, IL4
44Antioxidant Action of Vitamin-C367.2IL12A, IL10, IL1A, IL1B, IL1R1, IL15
45Glucocorticoid Receptor Signaling367.2IL12A, IL10, IL15, IL1A, IL1B, IL1R1
46STAT3 Pathway367.1IL10, IL12A, IL12RB2, IL15, TNFSF13B, TNF
47TGF-Beta Pathway366.7MAPK14, TNFSF13B, EGF, TGFB1, IL6, IL5
48Cytokine-cytokine receptor interaction206.7IL6, FASLG, IFNG, TPO, TNF, TNFSF13B
49p38 Signaling366.3EGF, IL12A, IL10, IL12RB2, IL15, IL1A
50MAPK Family Pathway366.3IL1R1, IL2, IL4, IL4R, IL5, IL6

Compounds for genes affiliated with Pemphigus Vulgaris

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32Novoseek , 18HMDB, 34PharmGKB, 9DrugBank, 42Tocris Bioscience
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Compounds related to pemphigus vulgaris according to GeneDecks:

(show top 50)    (show all 305)
idCompoundScoreTop Affiliating Genes
1hyaluronic acid32 18 11.4RNASE3, PLAUR, FASLG, CDH1
2ivig32 10.3IL1RAPL2, DSG3, DSG1, FASLG
3n acetylcysteine32 9.4IGHE, IL1R1, MMP9, CDH1, CD79A, PLAU
4rituximab32 34 9 9 12.3DSG1, TNFSF13B, FASLG, IL2, IL1R1, IL15
5endotoxin32 9.2MAPK14, FASLG, IL1RAPL2, IL1R1, CIITA, PLAUR
6calcitriol32 42 9 18 9 13.1EGF, PLAUR, PLAU, ALB, IL2, CDH1
7pge232 9.1IL1RAPL2, IL1R1, IL1A, CDH1, CIITA, IL1RN
8gold sodium thiomalate32 8.9IL1B, IL1R1, IL1RN, IL2, TNF, IFNG
9allergens32 8.6IL1RN, IL10, CD79A, CIITA, IL4, IL4R
10tgf beta132 8.4DSP, EGF, PLAUR, PLAU, TNF, FASLG
11chloroquine32 34 9 9 11.3CD79A, IL2, PLAU, TNF, CDH1, IL10
12il-1232 8.1TNF, IFNG, IL6, IL5, IL4, IL2
13arginine32 7.9HLA-DRB1, HLA-DQA1, TPO, PTPN22, HLA-B, HSPB1
14infliximab32 9 9 9.9IFNG, IGHE, IL6, IL4, IL1RN, IL1RAPL2
1512-o-tetradecanoylphorbol 13-acetate32 7.9HSPB1, MAPK14, IL1RAPL2, IL1R1, IL1A, MMP9
16gm-csf32 7.8IL1B, IL1A, IL15, IL10, IL2, IL4
17ribonucleic acid32 7.8TGFB1, RNPC3, PLAUR, PLAU, TPO, CIITA
18fibrinogen32 7.8IL1RN, HLA-B, IL1R1, CD79A, IL1RAPL2, C3
19pentoxifylline32 9 9 9.8TNF, IFNG, IL6, IL4, IL2, IL1RN
20calcium32 9 18 9 10.6TPO, TNFSF13B, PLAUR, DSP, DSG4, DSG3
21sb 20358032 42 8.6CDH1, MMP9, IL1R1, EGF, PLAUR, PLAU
22histamine32 18 8.4IGHE, ALB, TPMT, PLAU, RNASE3, IL5
23polyinosinic-polycytidylic acid32 7.3CIITA, HLA-B, IFNG, MAPK14, IL6, IL5
24neopterin32 7.3C3, IL1A, IL10, CD79A, IL1B, IL1R1
25curcumin32 7.3HSPB1, MAPK14, IL6, IL1B, IL1A, IL15
26prednisolone32 9 9 9.2RNASE3, TNF, TPMT, ALB, IFNG, IGHE
27simvastatin32 34 42 9 18 9 12.2IL1A, IL1RAPL2, IL1RN, IL4, CIITA, IL6
28nitric oxide32 9 18 9 10.1IL10, RNASE3, IL1B, CIITA, IL15, IL1A
29tacrolimus32 34 9 9 10.1MTOR, CD79A, FASLG, IFNG, IL2, IL5
30ly29400232 7.1IL10, MMP9, CDH1, IL1B, IL4, IL6
31il 1032 7.0IL6, IL5, IL4R, IL4, IL2, IL1RN
32hydrocortisone32 9 9 9.0EGF, PLAU, TNF, TPO, IFNG, IGHE
33creatinine32 7.0CDK2, CD79A, HLA-B, HSPB1, IGHE, IL1RN
34vegf32 6.9HLA-G, HSPB1, MAPK14, IL1RN, IL1RAPL2, IL1R1
35pdtc32 6.8MMP9, TGFB1, PLAU, TNF, CAT, IL6
36herbimycin a32 42 7.3EGF, PLAUR, PLAU, TNF, IFNG, MAPK14
37methotrexate32 34 42 9 9 10.3HLA-G, HLA-DRB1, HSPB1, ALB, IGHE, FASLG
38lactate32 6.2TNF, HLA-G, HLA-B, CAT, ALB, IGHE
39thymidine32 18 7.1PLAU, TNFSF13B, TNF, IFNG, FASLG, IL6
40genistein32 9 18 9 9.1FASLG, MTOR, IL6, IL5, IL2, IL1B
41adenylate32 5.8EGF, RNPC3, RNASE3, PLAU, TPO, TAP2
42rantes32 5.7IL1R1, IL1A, IL15, MMP9, CIITA, IL1RAPL2
43serine32 4.8DSP, DSG3, DSG1, ACHE, EGF, RNPC3
44actinomycin d32 4.6IL4, IL4R, IL6, FASLG, MAPK14, IGHE
45cyclosporin a32 42 5.5CIITA, MTOR, CD79A, CDK2, MMP9, TPMT
46indomethacin32 9 9 6.4IL1RAPL2, IL1R1, IL1B, IL1A, CDH1, CDK2
47retinoic acid32 42 18 6.2FASLG, CD79A, JUP, MTOR, CDK2, CDH1
48tyrosine32 3.8DSP, DSG3, DSG2, EIF6, EGF, RNPC3
49cycloheximide32 3.8TGFB1, EGF, PLAUR, PLAU, TNF, TPO
50dexamethasone32 42 34 9 9 7.0C3, TGFB1, EGF, RNASE3, PLAUR, TNF

GO Terms for genes affiliated with Pemphigus Vulgaris

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Sources:
12Gene Ontology
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Cellular components related to pemphigus vulgaris according to GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1internal side of plasma membraneGO:00989810.2JUP, CDH1, PTPN22, DSG1
2MHC class II protein complexGO:04261310.1HLA-DQA1, HLA-DRB1, HLA-DQB1
3desmosomeGO:03005710.1DSP, DSG4, DSG3, DSG2, DSG1, DSC3
4integral to lumenal side of endoplasmic reticulum membraneGO:0715569.7HLA-G, HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1
5ER to Golgi transport vesicle membraneGO:0125079.7HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-B, HLA-G
6cell surfaceGO:0099869.2PLAU, TPO, HSPB1, CDH1, PLAUR, ANXA9
7external side of plasma membraneGO:0098978.9IL4, HLA-DRB1, FASLG, CD79A, IFNG, TNF
8integral to plasma membraneGO:0058878.2IL1R1, IL4R, FASLG, HLA-DRB1, HLA-B, HLA-DQA1
9plasma membraneGO:0058866.7DSG1, DSG2, DSG3, DSG4, DSP, PERP
10extracellular regionGO:0055765.9MMP9, IL5, FASLG, IL6, IL4R, IL2
11extracellular spaceGO:0056155.4IL15, IL12A, IL10, IL1A, IL1B, IL1RN

Biological processes related to pemphigus vulgaris according to GeneDecks:

(show all 42)
idNameGO IDScoreTop Affiliating Genes
1cellular component disassembly involved in apoptotic processGO:00692110.5DSP, CDH1, DSG1, DSG3, DSG2
2homophilic cell adhesionGO:00715610.4CDH1, DSG4, DSG3, DSG1, DSC3, DSG2
3chronic inflammatory response to antigenic stimulusGO:00243910.4IL1RN, IL1B
4cell-cell adhesionGO:01633710.4CDH1, JUP, ANXA9, DSG1, DSP
5negative regulation of T cell proliferationGO:04213010.2HLA-DRB1, HLA-G, IL10, TGFB1
6regulation of branching involved in salivary gland morphogenesisGO:06069310.1CDH1, TNF
7regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312210.1HSPB1, TNF, IL1B
8positive regulation vascular endothelial growth factor productionGO:01057510.1IL1B, C3, IL1A, TGFB1
9positive regulation of calcidiol 1-monooxygenase activityGO:06055910.1TNF, IFNG, IL1B
10positive regulation of mitosisGO:0458409.9IL1A, IL1B, TNF, EGF
11positive regulation of interleukin-17 productionGO:0327409.9TGFB1, IL2, IL15
12positive regulation of membrane protein ectodomain proteolysisGO:0510449.8TNF, IFNG, IL1B
13positive regulation of interleukin-6 productionGO:0327559.8TNF, IL6, IL1A, IL1B
14positive regulation of cell divisionGO:0517819.8TGFB1, CAT, IL1B, IL1A
15negative regulation of growth of symbiont in hostGO:0441309.8IL10, IFNG, TNF
16positive regulation of immunoglobulin secretionGO:0510249.8IL5, IL2, IL6
17positive regulation of vitamin D biosynthetic processGO:0605579.8TNF, IFNG
18positive regulation of MHC class II biosynthetic processGO:0453489.8IFNG, IL4, IL10, CIITA
19positive regulation of interferon-gamma productionGO:0327299.7IL12A, TNF, IL2, IL1B, IL12RB2
20interferon-gamma-mediated signaling pathwayGO:0603339.7CIITA, HLA-G, HLA-DRB1, HLA-DQA1, HLA-B, IFNG
21positive regulation of protein phosphorylationGO:0019349.6C3, TGFB1, TNF, MTOR, IL1B
22positive regulation of isotype switching to IgG isotypesGO:0483049.6IL2, IFNG, IL4
23positive regulation of chemokine biosynthetic processGO:0450809.6IL1B, IL4, IFNG, TNF
24response to glucocorticoid stimulusGO:0513849.5IL10, IL1B, IL1RN, IL6, TNF
25regulation of isotype switchingGO:0451919.5IL4, IL10
26regulation of immune responseGO:0507769.4CDH1, C3, HLA-G, IL4, HLA-B
27lipopolysaccharide-mediated signaling pathwayGO:0316639.2IL1B, MAPK14, TNF, TGFB1
28positive regulation of T cell proliferationGO:0421029.2IL1B, IL4, IL12A, IL6, IFNG, IL15
29positive regulation of NF-kappaB transcription factor activityGO:0510929.2TNF, CAT, IL6, IL1B, TGFB1
30anti-apoptosisGO:0069169.2IL1A, IL10, IL1B, IL2, HSPB1, TNF
31positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.0TNF, IL10, IL1B, IL6, IL4, JUP
32response to hypoxiaGO:0016669.0IL1A, MMP9, IL1B, CAT, TGFB1, TNF
33inflammatory responseGO:0069548.9C3, IL10, IL1A, IL15, IL1B, TGFB1
34positive regulation of cell proliferationGO:0082848.8IL2, IL15, EGF, CDK2, IL6, FASLG
35cytokine-mediated signaling pathwayGO:0192218.6CIITA, IL12RB2, IL1A, IL1B, IL5, IL6
36apoptotic processGO:0069158.6PERP, DSP, DSG3, DSG2, DSG1, TNF
37negative regulation of apoptotic processGO:0430668.5TNF, CAT, HSPB1, IL1RN, ALB, IL6
38response to drugGO:0424938.3IL1RN, TNF, IFNG, IL4, IL10, MMP9
39positive regulation of transcription, DNA-dependentGO:0458938.1CIITA, CDK2, CDH1, IL10, IL1B, EGF
40signal transductionGO:0071658.0PLAUR, MTOR, IL15, IL1B, IL4R, C3
41immune responseGO:0069557.4HLA-DRB1, TNFSF13B, HLA-DQB1, HLA-DQA1, HLA-B, C3
42positive regulation of transcription from RNA polymerase II promoterGO:0459447.4CIITA, IL1A, IL1B, IL2, IL6, MAPK14

Molecular functions related to pemphigus vulgaris according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:03239510.1HLA-DRB1, HLA-DQB1, HLA-DQA1
2gamma-catenin bindingGO:04529510.0DSC3, CDH1, DSG1
3interleukin-1 receptor bindingGO:0051499.8IL1RN, IL1B, IL1A
4growth factor activityGO:0080837.8IL10, IL12A, IL1B, IL2, IL4, IL5
5cytokine activityGO:0051257.5IL10, TNFSF13B, TNF, IFNG, FASLG, IL6
6protein bindingGO:0055154.3IL12A, EGF, EIF6, ACHE, DSP, TGFB1

Sources for Pemphigus Vulgaris

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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