MCID: PMP005
MIFTS: 56

Pemphigus Vulgaris

Categories: Rare diseases, Skin diseases, Genetic diseases

Aliases & Classifications for Pemphigus Vulgaris

MalaCards integrated aliases for Pemphigus Vulgaris:

Name: Pemphigus Vulgaris 37 12 72 49 51 14 69
Familial Pemphigus Vulgaris 12 49
Pemphigus Vulgaris, Familial 69

Classifications:



Summaries for Pemphigus Vulgaris

NIH Rare Diseases : 49 Familial pemphigus vulgaris refers to a cluster of pemphigus vulgaris within a family. Pemphigus vulgaris is a rare autoimmune condition that is characterized by blisters and sores on the skin and mucus membranes. Although the exact cause of familial pemphigus vulgaris is unknown, autoimmune conditions generally occur when the body's immune system mistakenly attacks healthy tissue (in this case, the skin and mucus membranes). Most cases of pemphigus vulgaris occur sporadically in people with no family history of the condition; however, rare reports exist of "familial" cases which affect more than one member of a single family. In these cases, the underlying genetic cause is unknown, although an association between pemphigus vulgaris and certain HLA antigens has been identified. Treatment generally includes medications and other strategies to decrease blister formation, prevent infections and promote healing. Last updated: 12/17/2015

MalaCards based summary : Pemphigus Vulgaris, also known as familial pemphigus vulgaris, is related to pemphigus vegetans and pemphigus erythematosus, and has symptoms including abnormality of the oral cavity, atypical scarring of skin and urticaria. An important gene associated with Pemphigus Vulgaris is DSG3 (Desmoglein 3), and among its related pathways/superpathways are Developmental Biology and Keratinization. The drugs Triamcinolone and Mycophenolate mofetil have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and b cells, and related phenotype is integument.

Disease Ontology : 12 A pemphigus characterized by autosomal dominant blisters and erosions on the skin and mucous membranes erosions cause by autoantibodies to intercellular cement substance.

Wikipedia : 72 Pemphigus (/ˈpɛmfɪɡəs/ or /pɛmˈfaɪɡəs/) is a rare group of blistering autoimmune diseases that affect... more...

Related Diseases for Pemphigus Vulgaris

Diseases in the Pemphigus Vulgaris family:

Pemphigus Vulgaris, Familial

Diseases related to Pemphigus Vulgaris via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 186)
# Related Disease Score Top Affiliating Genes
1 pemphigus vegetans 32.3 DSC3 DSG1 PPL
2 pemphigus erythematosus 30.9 DSG3 DSP
3 grover's disease 30.1 DSP JUP
4 benign chronic pemphigus 29.9 DSP JUP
5 pemphigoid gestationis 29.8 DST HLA-DRB1
6 hypotrichosis 29.6 DSC3 DSG1 DSG4
7 pemphigus 29.4 DSC3 DSG1 DSG2 DSG3 DSG4 DSP
8 herpetiform pemphigus 29.4 DSG1 DSG3 DST
9 skin disease 29.3 DSG1 DSG3 DSG4 DST
10 pemphigus foliaceus 29.2 DSG1 DSG2 DSG3 DST EVPL HLA-DRB1
11 bullous pemphigoid 28.8 DSG1 DSG3 DSP DST EVPL HLA-DRB1
12 paraneoplastic pemphigus 27.6 DSC3 DSG1 DSG2 DSG3 DSP DST
13 pemphigus vulgaris, familial 12.8
14 bullous impetigo 10.4 DSG1 DSG3
15 erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper-ige 10.4 DSG1 DSP
16 epidermolysis bullosa, lethal acantholytic 10.4 DSP JUP
17 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.4
18 mucositis 10.3
19 cardiomyopathy, dilated, with woolly hair and keratoderma 10.3 DSP JUP
20 palmoplantar keratoderma and woolly hair 10.3 DSP JUP
21 striate palmoplantar keratoderma 10.3 DSG1 DSP
22 ectodermal dysplasia/skin fragility syndrome 10.3 DSP JUP
23 naxos disease 10.3 DSP JUP
24 arrhythmogenic right ventricular dysplasia, familial, 9 10.3 DSP JUP
25 arrhythmogenic right ventricular dysplasia, familial, 8 10.3 DSP JUP
26 blood group, i system 10.3
27 esophagitis 10.2
28 darier-white disease 10.2 DSP JUP
29 nodular malignant melanoma 10.2 DSG1 DSG3
30 palmoplantar keratosis 10.2 DSG1 DSP JUP
31 arrhythmogenic right ventricular dysplasia, familial, 1 10.2 DSP JUP
32 microinvasive gastric cancer 10.2 CDH1 JUP
33 paronychia 10.2
34 lichen planus 10.2
35 gingivitis 10.1
36 thyroiditis 10.1
37 ritter's disease 10.1 DSG1 DSG2 DSG4
38 herpes simplex 10.1
39 follicular dendritic cell sarcoma 10.0 DSP EVPL PPL
40 rheumatoid arthritis 10.0
41 episodic pain syndrome, familial, 1 10.0
42 arthritis 10.0
43 sarcoma 10.0
44 cicatricial pemphigoid 10.0
45 pustulosis of palm and sole 10.0
46 lupus erythematosus 10.0
47 psoriasis 10.0
48 oral lichen planus 10.0
49 familial isolated arrhythmogenic ventricular dysplasia, right dominant form 10.0 DSG2 DSP JUP
50 familial isolated arrhythmogenic ventricular dysplasia, biventricular form 10.0 DSG2 DSP JUP

Graphical network of the top 20 diseases related to Pemphigus Vulgaris:



Diseases related to Pemphigus Vulgaris

Symptoms & Phenotypes for Pemphigus Vulgaris

Human phenotypes related to Pemphigus Vulgaris:

31 (show all 9)
# Description HPO Frequency HPO Source Accession
1 abnormality of the oral cavity 31 hallmark (90%) HP:0000163
2 atypical scarring of skin 31 hallmark (90%) HP:0000987
3 urticaria 31 hallmark (90%) HP:0001025
4 weight loss 31 hallmark (90%) HP:0001824
5 autoimmunity 31 hallmark (90%) HP:0002960
6 abnormal blistering of the skin 31 hallmark (90%) HP:0008066
7 feeding difficulties in infancy 31 hallmark (90%) HP:0008872
8 acantholysis 31 hallmark (90%) HP:0100792
9 recurrent cutaneous abscess formation 31 hallmark (90%) HP:0100838

MGI Mouse Phenotypes related to Pemphigus Vulgaris:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.23 CDH1 DSC3 DSG1 DSG3 DSG4 DSP

Drugs & Therapeutics for Pemphigus Vulgaris

Drugs for Pemphigus Vulgaris (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
2
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
3
Mycophenolic acid Approved Phase 3 24280-93-1 446541
4
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
6
Prednisone Approved, Vet_approved Phase 3,Phase 2,Early Phase 1 53-03-2 5865
7
rituximab Approved Phase 3 174722-31-7 10201696
8
Acetaminophen Approved Phase 3 103-90-2 1983
9
Cetirizine Approved Phase 3 83881-51-0 2678
10
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
11 Anti-Inflammatory Agents Phase 3,Phase 2
12 glucocorticoids Phase 3,Phase 2
13 Hormone Antagonists Phase 3,Phase 2
14 Hormones Phase 3,Phase 2
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
16 Immunosuppressive Agents Phase 3,Phase 2,Early Phase 1
17 triamcinolone acetonide Phase 3
18 Triamcinolone diacetate Phase 3
19 Triamcinolone hexacetonide Phase 3
20 Anti-Bacterial Agents Phase 3,Phase 2,Early Phase 1
21 Antibiotics, Antitubercular Phase 3,Early Phase 1
22 Anti-Infective Agents Phase 3,Phase 2,Early Phase 1
23 Antitubercular Agents Phase 3
24 Antirheumatic Agents Phase 3,Phase 2
25 Antibodies Phase 3,Phase 2
26 Antibodies, Monoclonal Phase 3,Phase 2
27 Immunoglobulins Phase 3,Phase 2
28 Analgesics Phase 3,Phase 2
29 Analgesics, Non-Narcotic Phase 3,Phase 2
30 Antineoplastic Agents, Hormonal Phase 3,Phase 2
31 Gastrointestinal Agents Phase 3,Phase 2
32 Methylprednisolone acetate Phase 3,Phase 2
33 Methylprednisolone Hemisuccinate Phase 3,Phase 2
34 Peripheral Nervous System Agents Phase 3,Phase 2
35 Prednisolone acetate Phase 3,Phase 2
36 Prednisolone hemisuccinate Phase 3,Phase 2
37 Prednisolone phosphate Phase 3,Phase 2
38 Anti-Allergic Agents Phase 3
39 Antiemetics Phase 3
40 Antipyretics Phase 3
41 Autonomic Agents Phase 3
42 Histamine Antagonists Phase 3
43 Histamine H1 Antagonists Phase 3
44 Histamine H1 Antagonists, Non-Sedating Phase 3
45
Histamine Phosphate Phase 3 51-74-1 65513
46 Neuroprotective Agents Phase 3
47 Neurotransmitter Agents Phase 3
48 Protective Agents Phase 3
49
Azathioprine Approved Phase 2 446-86-6 2265
50
Etanercept Approved, Investigational Phase 2 185243-69-0

Interventional clinical trials:

(show all 20)

# Name Status NCT ID Phase Drugs
1 Comparison Between Injections of Steroids and Autologous Platelet Rich Plasma in the Oral Erosions of Pemphigus Vulgaris Completed NCT02828163 Phase 3 Triamcinolone Acetonide
2 A Study to Assess the Effect of CellCept (Mycophenolate Mofetil) and Reduced Corticosteroids in Patients With Active Pemphigus Vulgaris (PV) Completed NCT00683930 Phase 3 Mycophenolate Mofetil 2 g/Day;Mycophenolate Mofetil (MMF) 3 g/Day;Placebo
3 A Study to Evaluate the Efficacy and Safety of Rituximab Versus Mycophenolate Mofetil (MMF) in Participants With Pemphigus Vulgaris (PV) Recruiting NCT02383589 Phase 3 Mycophenolate Mofetil Placebo;Mycophenolate Mofetil;Rituximab;Rituximab Placebo
4 Efficacy and Safety of Ofatumumab in Treatment of Pemphigus Vulgaris Active, not recruiting NCT01920477 Phase 3
5 Long-Term Extension Study of Ofatumumab in Subjects With Pemphigus Vulgaris Terminated NCT02613910 Phase 3 Ofatumumab;Acetaminophen/paracetamol;Antihistamine (cetirizine or equivalent);Prednisone/Prednisolone
6 Use of KC706 for the Treatment of Pemphigus Vulgaris Completed NCT00606749 Phase 2 KC706
7 Azathioprine Versus Placebo in Pemphigus Vulgaris Treated With Prednisolone Completed NCT00626678 Phase 2 Azathioprine;Prednisone;Placebo
8 Study of Etanercept (Enbrel) in the Treatment of Pemphigus Vulgaris Completed NCT00135720 Phase 2 Enbrel (Etanercept)
9 Use of Infliximab for the Treatment of Pemphigus Vulgaris Completed NCT00283712 Phase 2 Infliximab
10 A Study to Evaluate the Safety, PD, PK and Efficacy of ARGX-113 in Patients With Pemphigus Vulgaris Recruiting NCT03334058 Phase 2 ARGX-113
11 A Study of PRN1008 in Adult Patients With Pemphigus Vulgaris Recruiting NCT02704429 Phase 2 PRN1008
12 Study of Efficacy and Safety of VAY736 in Patients With Pemphigus Vulgaris Active, not recruiting NCT01930175 Phase 2 VAY736;Placebo to VAY736;VAY736
13 Efficacy of Dapsone as a Steroid Sparing Agent in Pemphigus Vulgaris Terminated NCT00429533 Phase 2 Dapsone
14 Randomized Trial of IVIg With or Without Cyclophosphamide in Pemphigus Terminated NCT00483119 Phase 2 intravenous immunoglobulin;cyclophosphamide
15 Safety Study of PI-0824 to Treat Pemphigus Vulgaris Completed NCT00063752 Phase 1 PI-0824
16 Polyclonal Regulatory T Cells (PolyTregs) for Pemphigus Recruiting NCT03239470 Phase 1
17 A Safety Study of SYNT001 in Subjects With Pemphigus (Vulgaris or Foliaceus) Recruiting NCT03075904 Phase 1 SYNT001
18 Autoimmune Blistering Diseases Study Recruiting NCT02753777
19 Serum IL-21 Levels in Patients With Pemphigus Vulgaris Not yet recruiting NCT03177213
20 Evaluating Sirolimus to Treat Autoimmune Blistering Dermatosis Pemphigus Terminated NCT01313923 Early Phase 1 Sirolimus (formerly known as Rapamycin)

Search NIH Clinical Center for Pemphigus Vulgaris

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Pemphigus Vulgaris cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pemphigus Vulgaris:
Hematopoietic stem cells for pemphigus

Genetic Tests for Pemphigus Vulgaris

Anatomical Context for Pemphigus Vulgaris

MalaCards organs/tissues related to Pemphigus Vulgaris:

38
Skin, T Cells, B Cells, Thyroid, Testes, Eye, Lung

Publications for Pemphigus Vulgaris

Articles related to Pemphigus Vulgaris:

(show top 50) (show all 914)
# Title Authors Year
1
A Case of Concomitant Pemphigus Foliaceus and Oral Pemphigus Vulgaris. ( 29340948 )
2018
2
Association between HLA-DQB1 polymorphisms and pemphigus vulgaris: A meta-analysis. ( 29182409 )
2018
3
Pemphigus trigger factors: special focus on pemphigus vulgaris and pemphigus foliaceus. ( 29110080 )
2018
4
A case of pemphigus vulgaris associated with ulcerative colitis. ( 29422810 )
2018
5
Pemphigus Vulgaris and Radiotherapy. ( 29097073 )
2018
6
An Oral Disease Severity Score (ODSS) validated for use in oral pemphigus vulgaris. ( 29297927 )
2018
7
Sixteen-year history of rituximab therapy for 1085 pemphigus vulgaris patients: A systematic review. ( 29132070 )
2018
8
Feasibility study for clinical application of caspase-3 inhibitors in Pemphigus vulgaris. ( 29105150 )
2017
9
Pemphigus Vulgaris and Pemphigus Foliaceus: Differences in Epidemiology and Mortality. ( 28536732 )
2017
10
Recurrent Paronychia as a Presenting Manifestation of Pemphigus Vulgaris: A Case Report. ( 28611998 )
2017
11
Salivary Samples for the Diagnosis of Pemphigus vulgaris Using the BIOCHIP Approach: a Pilot Study. ( 28064226 )
2017
12
Location of oral lesions predicts treatment resistance in pemphigus vulgaris. ( 29313939 )
2017
13
Miniaturization of sebaceous glands: A novel histopathological finding in pemphigus vulgaris and pemphigus foliaceus of the scalp. ( 28632917 )
2017
14
Anterior Scleritis Associated with Pemphigus Vulgaris. ( 29095065 )
2017
15
A novel lateral flow immunoassay for the rapid detection of anti-Dsg3 IgG serum autoantibodies in pemphigus vulgaris. ( 29278440 )
2017
16
Successful and well-tolerated bi-weekly immunoadsorption regimen in pemphigus vulgaris. ( 29096849 )
2017
17
A reciprocal HLA-Disease Association in Rheumatoid Arthritis and Pemphigus Vulgaris. ( 27814654 )
2017
18
Delayed and localized pemphigus vulgaris after breast cancer radiotherapy. ( 28892216 )
2017
19
A review on botanicals with wound healing activity for pemphigus vulgaris<i>:</i>perspective of traditional Persian medicine and conventional medicine. ( 29299431 )
2017
20
Rituximab and short-course prednisone as the new gold standard for new-onset pemphigus vulgaris and pemphigus foliaceus. ( 29192985 )
2017
21
Effects of L-carnitine supplementation on biomarkers of oxidative stress, antioxidant capacity and lipid profile, in patients with pemphigus vulgaris: a randomized, double-blind, placebo-controlled trial. ( 28832573 )
2017
22
Alopecia developed in a transitional case from pemphigus foliaceus to pemphigus vulgaris. ( 28681532 )
2017
23
Virusreaktivierung tAouscht Rezidiv des Pemphigus vulgaris bei einer immunsupprimierten Patientin vor. ( 29106014 )
2017
24
Geographical foci and epidemiological changes of pemphigus vulgaris in four decades in Southeastern Brazil. ( 28737218 )
2017
25
Extragenital lichen sclerosus et atrophicus co-exististing with pemphigus vulgaris. ( 28217480 )
2017
26
Th1 polarizing I^I'-T cells and Scavenger Receptors contribute to the pathogenesis of Pemphigus Vulgaris. ( 28815581 )
2017
27
HLA-E*0101/0103X is Associated with Susceptibility to Pemphigus Vulgaris: A Case-control Study. ( 29252170 )
2017
28
Oral pemphigus vulgaris: Liquid-based cytological findings and pitfalls. ( 28799730 )
2017
29
Pregnancy outcome after rituximab treatment before conception in patients affected by severe pemphigus vulgaris/superficialis. ( 28079925 )
2017
30
The Effect of Low Level Laser Therapy on Pemphigus Vulgaris Lesions: A Pilot Study. ( 29071023 )
2017
31
Rituximab administration in a patient with pemphigus vulgaris following reactivation of occult hepatitis B virus infection. ( 28633752 )
2017
32
British Association of Dermatologists' guidelines for the management of pemphigus vulgaris 2017. ( 29192996 )
2017
33
Viral reactivation imitates relapse of pemphigus vulgaris in an immunosuppressed patient. ( 28921892 )
2017
34
Herpes simplex virus 1 and cytomegalovirus are associated with pemphigus vulgaris but not with pemphigus foliaceus disease. ( 28370424 )
2017
35
Exacerbated pemphigus vulgaris superinfected with herpes virus II, chemoattracting a florid inflammatory response. ( 28704987 )
2017
36
Cutaneous Mucormycosis: A Fatal Complication of Immunosuppressant Therapy for Pemphigus Vulgaris. ( 29282189 )
2017
37
Assessment of the Prevalence and Risk Factors Associated With Glucocorticoid-Induced Diabetes Mellitus in Pemphigus Vulgaris Patients. ( 28843238 )
2017
38
Pemphigus vulgaris and pemphigus foliaceus determined by CD86 and CTLA4 polymorphisms. ( 28274366 )
2017
39
Oral mucous membrane pemphigoid and pemphigus vulgaris- a retrospective two-center cohort study. ( 28084005 )
2017
40
NUDT15 polymorphism and severe azathioprine-induced myelosuppression in a Chinese man with pemphigus vulgaris. ( 28733976 )
2017
41
Correlation between polymorphisms of the NR3C1 gene and glucocorticoid effectiveness in patients with pemphigus vulgaris. ( 28928407 )
2017
42
Grover's disease in a patient with pemphigus vulgaris. ( 28766705 )
2017
43
Study of the association between human leukocyte antigens (HLA) and pemphigus vulgaris in Brazilian patients. ( 28197992 )
2017
44
Mean Platelet Volume in Pemphigus Vulgaris. ( 28681645 )
2017
45
Dermatoscopy in Diagnosis of Cutaneous Myiasis Arising in Pemphigus Vulgaris Lesions. ( 28794566 )
2017
46
Selective Plasma Exchange for the Removal of Pemphigus Autoantibodies, Fibrinogen, and Factor XIII in Pemphigus Vulgaris. ( 28661086 )
2017
47
Cytokine Indexes in Pemphigus Vulgaris: Perception of Its Immunpathogenesis and Hopes for Non-Steroidal Treatment. ( 29201111 )
2017
48
Relieving Pain in Oral Lesions of Pemphigus Vulgaris Using the Non-ablative, Non-thermal, CO2 Laser Therapy (NTCLT): Preliminary Results of a Novel Approach. ( 28912937 )
2017
49
Appearance of anti-desmocollin 1 autoantibodies leading to a vegetative lesion in a pemphigus vulgaris patient. ( 28734006 )
2017
50
Pemphigus vulgaris successfully treated with doxycycline monotherapy. ( 27416094 )
2016

Variations for Pemphigus Vulgaris

Expression for Pemphigus Vulgaris

Search GEO for disease gene expression data for Pemphigus Vulgaris.

Pathways for Pemphigus Vulgaris

GO Terms for Pemphigus Vulgaris

Cellular components related to Pemphigus Vulgaris according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.9 CDH1 DSC3 DSG1 DSG2 DSG3 DSG4
2 intermediate filament GO:0005882 9.71 DSP DST JUP
3 cell-cell junction GO:0005911 9.65 DSC3 DSG1 DSG2 DSP JUP
4 intercalated disc GO:0014704 9.63 DSG2 DSP JUP
5 lateral plasma membrane GO:0016328 9.62 CDH1 DSG1 DSG2 JUP
6 cytoplasmic side of plasma membrane GO:0009898 9.61 CDH1 DSG1 JUP
7 cornified envelope GO:0001533 9.61 DSC3 DSG1 DSG2 DSG3 DSG4 DSP
8 fascia adherens GO:0005916 9.51 DSP JUP
9 catenin complex GO:0016342 9.49 CDH1 JUP
10 hemidesmosome GO:0030056 9.48 DST JUP
11 desmosome GO:0030057 9.28 DSC3 DSG1 DSG2 DSG3 DSG4 DSP
12 membrane GO:0016020 10.3 CDH1 DSC3 DSG1 DSG2 DSG3 DSG4
13 plasma membrane GO:0005886 10.15 CDH1 DSC3 DSG1 DSG2 DSG3 DSG4
14 extracellular exosome GO:0070062 10.1 CDH1 DSG1 DSG2 DSG3 DSP DST

Biological processes related to Pemphigus Vulgaris according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.86 CDH1 DSC3 DSG1 DSG2 DSG3 DSG4
2 cell-cell adhesion GO:0098609 9.77 CDH1 DSG1 DSG4 DSP JUP
3 keratinocyte differentiation GO:0030216 9.69 DSG4 DSP EVPL
4 adherens junction organization GO:0034332 9.63 CDH1 DSP JUP
5 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.63 CDH1 DSC3 DSG1 DSG2 DSG3 DSG4
6 regulation of heart rate by cardiac conduction GO:0086091 9.61 DSG2 DSP JUP
7 keratinization GO:0031424 9.61 DSC3 DSG1 DSG2 DSG3 DSG4 DSP
8 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.58 DSG2 DSP JUP
9 response to progesterone GO:0032570 9.55 DSG1 DSG2
10 maternal process involved in female pregnancy GO:0060135 9.54 DSG1 DSG2
11 intermediate filament cytoskeleton organization GO:0045104 9.52 DSP DST
12 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 9.5 DSG2 DSP JUP
13 desmosome organization GO:0002934 9.49 DSG2 DSP
14 cellular response to indole-3-methanol GO:0071681 9.48 CDH1 JUP
15 cornification GO:0070268 9.28 DSC3 DSG1 DSG2 DSG3 DSG4 DSP

Molecular functions related to Pemphigus Vulgaris according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cadherin binding GO:0045296 9.62 CDH1 EVPL JUP PPL
2 structural molecule activity GO:0005198 9.54 DSP EVPL JUP
3 calcium ion binding GO:0005509 9.5 CDH1 DSC3 DSG1 DSG2 DSG3 DSG4
4 cell adhesion molecule binding GO:0050839 9.46 CDH1 DSG2 DSP JUP
5 gamma-catenin binding GO:0045295 9.26 CDH1 DSG1
6 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 8.8 DSG2 DSP JUP

Sources for Pemphigus Vulgaris

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....