MCID: PMP005
MIFTS: 51

Pemphigus Vulgaris

Categories: Rare diseases, Skin diseases, Genetic diseases

Aliases & Classifications for Pemphigus Vulgaris

MalaCards integrated aliases for Pemphigus Vulgaris:

Name: Pemphigus Vulgaris 38 12 50 52 14 69
Familial Pemphigus Vulgaris 12 50
Pemphigus Vulgaris, Familial 69

Classifications:



Summaries for Pemphigus Vulgaris

NIH Rare Diseases : 50 familial pemphigus vulgaris refers to a cluster of pemphigus vulgaris within a family. pemphigus vulgaris is a rare autoimmune condition that is characterized by blisters and sores on the skin and mucus membranes. although the exact cause of familial pemphigus vulgaris is unknown, autoimmune conditions generally occur when the body's immune system mistakenly attacks healthy tissue (in this case, the skin and mucus membranes). most cases of pemphigus vulgaris occur sporadically in people with no family history of the condition; however, rare reports exist of "familial" cases which affect more than one member of a single family. in these cases, the underlying genetic cause is unknown, although an association between pemphigus vulgaris and certain hla antigens has been identified. treatment generally includes medications and other strategies to decrease blister formation, prevent infections and promote healing. last updated: 12/17/2015

MalaCards based summary : Pemphigus Vulgaris, also known as familial pemphigus vulgaris, is related to pemphigus vulgaris, familial and pemphigus, and has symptoms including abnormality of the oral cavity, atypical scarring of skin and urticaria. An important gene associated with Pemphigus Vulgaris is DSG3 (Desmoglein 3), and among its related pathways/superpathways are Developmental Biology and Cell adhesion molecules (CAMs). The drugs Triamcinolone and Mycophenolate mofetil have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and b cells, and related phenotype is integument.

Disease Ontology : 12 A pemphigus characterized by autosomal dominant blisters and erosions on the skin and mucous membranes erosions cause by autoantibodies to intercellular cement substance.

Wikipedia : 72 Pemphigus vulgaris is a rare chronic blistering skin disease and the most common form of pemphigus. It... more...

Related Diseases for Pemphigus Vulgaris

Diseases in the Pemphigus Vulgaris family:

Pemphigus Vulgaris, Familial

Diseases related to Pemphigus Vulgaris via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
id Related Disease Score Top Affiliating Genes
1 pemphigus vulgaris, familial 12.4
2 pemphigus 11.7
3 pemphigus vegetans 11.4
4 pemphigus foliaceus 10.6
5 isolated scaphocephaly 10.6 DSG1 DSG3
6 x-linked intellectual disability-hypogammaglobulinemia-progressive neurological deterioration syndrome 10.6 DSG3 DSP
7 arrhythmogenic right ventricular dysplasia 10 10.6 DSG1 DSP
8 dilated cardiomyopathy with woolly hair, keratoderma, and tooth agenesis 10.5 DSP JUP
9 growth retardation hydrocephaly lung hypoplasia 10.5 DSP JUP
10 arrhythmogenic right ventricular dysplasia 8 10.5 DSP JUP
11 hypercholesterolemia, familial 10.5 DSP JUP
12 ectodermal dysplasia/skin fragility syndrome 10.4 DSP JUP
13 vesicoureteral reflux 7 10.4 DSP JUP
14 skin fragility-woolly hair syndrome 10.4 DSP JUP
15 idiopathic neonatal atrial flutter 10.4 DSG1 DSP
16 arrhythmogenic right ventricular dysplasia 12 10.3 DSP JUP
17 bullous pemphigoid 10.3
18 carotid artery disease 10.3 DSG1 DSP JUP
19 mucositis 10.3
20 skin amelanotic melanoma 10.2 DSG1 DSG3
21 paraneoplastic pemphigus 10.2
22 pyloric antrum cancer 10.2 CDH1 JUP
23 loeys-dietz syndrome 5 10.2 DSP JUP
24 lethal midline granuloma 10.2 DSG1 DSG2 DSG4
25 ischio-vertebral syndrome 10.2 DSC3 DSG1 PPL
26 gastric cardia adenocarcinoma 10.1 DSP PPL
27 acrokeratosis verruciformis 10.1 CDH1 DSP JUP
28 esophagitis 10.1
29 pemphigus erythematosus 10.1
30 paronychia 10.1
31 lichen planus 10.1
32 ulnar hemimelia, unilateral 10.1 DSG2 DSP JUP
33 ulnar hemimelia, bilateral 10.0 DSG2 DSP JUP
34 tibial hemimelia, bilateral 10.0 DSG2 DSP JUP
35 thyroiditis 10.0
36 gingivitis 10.0
37 penis agenesis 10.0 DST HLA-DRB1
38 autoimmune disease of skin and connective tissue 10.0 DSG2 DSP JUP
39 herpes simplex 10.0
40 cicatricial pemphigoid 9.9
41 arthritis 9.9
42 lupus erythematosus 9.9
43 rheumatoid arthritis 9.9
44 oral lichen planus 9.9
45 psoriasis 9.9
46 sarcoma 9.9
47 retinitis pigmentosa 4, autosomal dominant or recessive 9.9 CDH1 DSG1 DSP JUP
48 usher syndrome 9.9 DSG2 DSP JUP
49 intellectual disability-short stature-hypertelorism syndrome 9.9 DSG1 DSG3 DST
50 thymoma 9.9

Graphical network of the top 20 diseases related to Pemphigus Vulgaris:



Diseases related to Pemphigus Vulgaris

Symptoms & Phenotypes for Pemphigus Vulgaris

Human phenotypes related to Pemphigus Vulgaris:

32 (show all 9)
id Description HPO Frequency HPO Source Accession
1 abnormality of the oral cavity 32 hallmark (90%) HP:0000163
2 atypical scarring of skin 32 hallmark (90%) HP:0000987
3 urticaria 32 hallmark (90%) HP:0001025
4 weight loss 32 hallmark (90%) HP:0001824
5 autoimmunity 32 hallmark (90%) HP:0002960
6 abnormal blistering of the skin 32 hallmark (90%) HP:0008066
7 feeding difficulties in infancy 32 hallmark (90%) HP:0008872
8 acantholysis 32 hallmark (90%) HP:0100792
9 recurrent cutaneous abscess formation 32 hallmark (90%) HP:0100838

MGI Mouse Phenotypes related to Pemphigus Vulgaris:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.1 CDH1 DSC3 DSG3 DSG4 DSP JUP

Drugs & Therapeutics for Pemphigus Vulgaris

Drugs for Pemphigus Vulgaris (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 75)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
2
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
3
Mycophenolic acid Approved Phase 3 24280-93-1 446541
4
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
6
Prednisone Approved, Vet_approved Phase 3,Phase 2,Early Phase 1 53-03-2 5865
7
rituximab Approved Phase 3 174722-31-7 10201696
8
Acetaminophen Approved Phase 3 103-90-2 1983
9
Cetirizine Approved Phase 3 83881-51-0 2678
10
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
11 Anti-Inflammatory Agents Phase 3,Phase 2
12 glucocorticoids Phase 3,Phase 2
13 Hormone Antagonists Phase 3,Phase 2
14 Hormones Phase 3,Phase 2
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
16 Immunosuppressive Agents Phase 3,Phase 2,Early Phase 1
17 triamcinolone acetonide Phase 3
18 Triamcinolone diacetate Phase 3
19 Triamcinolone hexacetonide Phase 3
20 Anti-Bacterial Agents Phase 3,Phase 2,Early Phase 1
21 Antibiotics, Antitubercular Phase 3,Early Phase 1
22 Antirheumatic Agents Phase 3,Phase 2
23 Antibodies Phase 3,Phase 2
24 Antibodies, Monoclonal Phase 3,Phase 2
25 Immunoglobulins Phase 3,Phase 2
26 Analgesics Phase 3,Phase 2
27 Analgesics, Non-Narcotic Phase 3,Phase 2
28 Antineoplastic Agents, Hormonal Phase 3,Phase 2
29 Gastrointestinal Agents Phase 3,Phase 2
30 Methylprednisolone acetate Phase 3,Phase 2
31 Methylprednisolone Hemisuccinate Phase 3,Phase 2
32 Peripheral Nervous System Agents Phase 3,Phase 2
33 Prednisolone acetate Phase 3,Phase 2
34 Prednisolone hemisuccinate Phase 3,Phase 2
35 Prednisolone phosphate Phase 3,Phase 2
36 Anti-Allergic Agents Phase 3
37 Antiemetics Phase 3
38 Antipyretics Phase 3
39 Autonomic Agents Phase 3
40 Histamine Antagonists Phase 3
41 Histamine H1 Antagonists Phase 3
42 Histamine H1 Antagonists, Non-Sedating Phase 3
43
Histamine Phosphate Phase 3 51-74-1 65513
44 Neuroprotective Agents Phase 3
45 Neurotransmitter Agents Phase 3
46 Protective Agents Phase 3
47
Azathioprine Approved Phase 2 446-86-6 2265
48
Etanercept Approved, Investigational Phase 2 185243-69-0
49
Infliximab Approved Phase 2 170277-31-3
50
Dapsone Approved, Investigational Phase 2 80-08-0 2955

Interventional clinical trials:

(show all 19)

id Name Status NCT ID Phase Drugs
1 Comparison Between Injections of Steroids and Autologous Platelet Rich Plasma in the Oral Erosions of Pemphigus Vulgaris Completed NCT02828163 Phase 3 Triamcinolone Acetonide
2 A Study to Assess the Effect of CellCept (Mycophenolate Mofetil) and Reduced Corticosteroids in Patients With Active Pemphigus Vulgaris (PV) Completed NCT00683930 Phase 3 Mycophenolate Mofetil 2 g/Day;Mycophenolate Mofetil (MMF) 3 g/Day;Placebo
3 A Study to Evaluate the Efficacy and Safety of Rituximab Versus Mycophenolate Mofetil (MMF) in Participants With Pemphigus Vulgaris (PV) Recruiting NCT02383589 Phase 3 Mycophenolate Mofetil Placebo;Mycophenolate Mofetil;Rituximab;Rituximab Placebo
4 Efficacy and Safety of Ofatumumab in Treatment of Pemphigus Vulgaris Active, not recruiting NCT01920477 Phase 3
5 Long-Term Extension Study of Ofatumumab in Subjects With Pemphigus Vulgaris Terminated NCT02613910 Phase 3 Ofatumumab;Acetaminophen/paracetamol;Antihistamine (cetirizine or equivalent);Prednisone/Prednisolone
6 Use of KC706 for the Treatment of Pemphigus Vulgaris Completed NCT00606749 Phase 2 KC706
7 Azathioprine Versus Placebo in Pemphigus Vulgaris Treated With Prednisolone Completed NCT00626678 Phase 2 Azathioprine;Prednisone;Placebo
8 Study of Etanercept (Enbrel) in the Treatment of Pemphigus Vulgaris Completed NCT00135720 Phase 2 Enbrel (Etanercept)
9 Use of Infliximab for the Treatment of Pemphigus Vulgaris Completed NCT00283712 Phase 2 Infliximab;Prednisone
10 A Study of PRN1008 in Adult Patients With Pemphigus Vulgaris Recruiting NCT02704429 Phase 2 PRN1008
11 Study of Efficacy and Safety of VAY736 in Patients With Pemphigus Vulgaris Active, not recruiting NCT01930175 Phase 2 VAY736;Placebo to VAY736;VAY736
12 Efficacy of Dapsone as a Steroid Sparing Agent in Pemphigus Vulgaris Terminated NCT00429533 Phase 2 Dapsone
13 Randomized Trial of IVIg With or Without Cyclophosphamide in Pemphigus Terminated NCT00483119 Phase 2 intravenous immunoglobulin;cyclophosphamide
14 Safety Study of PI-0824 to Treat Pemphigus Vulgaris Completed NCT00063752 Phase 1 PI-0824
15 Polyclonal Regulatory T Cells (PolyTregs) for Pemphigus Recruiting NCT03239470 Phase 1
16 A Safety Study of SYNT001 in Subjects With Pemphigus (Vulgaris or Foliaceus) Recruiting NCT03075904 Phase 1 SYNT001
17 Autoimmune Blistering Diseases Study Recruiting NCT02753777
18 Serum IL-21 Levels in Patients With Pemphigus Vulgaris Not yet recruiting NCT03177213
19 Evaluating Sirolimus to Treat Autoimmune Blistering Dermatosis Pemphigus Terminated NCT01313923 Early Phase 1 Sirolimus (formerly known as Rapamycin)

Search NIH Clinical Center for Pemphigus Vulgaris

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Pemphigus Vulgaris cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pemphigus Vulgaris:
Hematopoietic stem cells for pemphigus

Genetic Tests for Pemphigus Vulgaris

Anatomical Context for Pemphigus Vulgaris

MalaCards organs/tissues related to Pemphigus Vulgaris:

39
Skin, T Cells, B Cells, Thyroid, Testes, Eye, Neutrophil

Publications for Pemphigus Vulgaris

Articles related to Pemphigus Vulgaris:

(show top 50) (show all 892)
id Title Authors Year
1
NUDT15 polymorphism and severe azathioprine-induced myelosuppression in a Chinese man with pemphigus vulgaris. ( 28733976 )
2017
2
Salivary Samples for the Diagnosis of Pemphigus vulgaris Using the BIOCHIP Approach: a Pilot Study. ( 28064226 )
2017
3
Appearance of anti-desmocollin 1 autoantibodies leading to a vegetative lesion in a pemphigus vulgaris patient. ( 28734006 )
2017
4
Exacerbated pemphigus vulgaris superinfected with herpes virus II, chemoattracting a florid inflammatory response. ( 28704987 )
2017
5
Grover's disease in a patient with pemphigus vulgaris. ( 28766705 )
2017
6
Miniaturization of sebaceous glands: A novel histopathological finding in pemphigus vulgaris and pemphigus foliaceus of the scalp. ( 28632917 )
2017
7
Pemphigus Vulgaris and Pemphigus Foliaceus: Differences in Epidemiology and Mortality. ( 28536732 )
2017
8
Geographical foci and epidemiological changes of pemphigus vulgaris in four decades in Southeastern Brazil. ( 28737218 )
2017
9
Delayed and localized pemphigus vulgaris after breast cancer radiotherapy. ( 28892216 )
2017
10
Oral mucous membrane pemphigoid and pemphigus vulgaris- a retrospective two-center cohort study. ( 28084005 )
2017
11
Mean Platelet Volume in Pemphigus Vulgaris. ( 28681645 )
2017
12
Pemphigus vulgaris and pemphigus foliaceus determined by CD86 and CTLA4 polymorphisms. ( 28274366 )
2017
13
Rituximab administration in a patient with pemphigus vulgaris following reactivation of occult hepatitis B virus infection. ( 28633752 )
2017
14
Herpes simplex virus 1 and cytomegalovirus are associated with pemphigus vulgaris but not with pemphigus foliaceus disease. ( 28370424 )
2017
15
Oral pemphigus vulgaris: Liquid-based cytological findings and pitfalls. ( 28799730 )
2017
16
A reciprocal HLA-Disease Association in Rheumatoid Arthritis and Pemphigus Vulgaris. ( 27814654 )
2017
17
Viral reactivation imitates relapse of pemphigus vulgaris in an immunosuppressed patient. ( 28921892 )
2017
18
Selective Plasma Exchange for the Removal of Pemphigus Autoantibodies, Fibrinogen, and Factor XIII in Pemphigus Vulgaris. ( 28661086 )
2017
19
Dermatoscopy in Diagnosis of Cutaneous Myiasis Arising in Pemphigus Vulgaris Lesions. ( 28794566 )
2017
20
Assessment of the Prevalence and Risk Factors Associated With Glucocorticoid-Induced Diabetes Mellitus in Pemphigus Vulgaris Patients. ( 28843238 )
2017
21
Recurrent Paronychia as a Presenting Manifestation of Pemphigus Vulgaris: A Case Report. ( 28611998 )
2017
22
Correlation between polymorphisms of the NR3C1 gene and glucocorticoid effectiveness in patients with pemphigus vulgaris. ( 28928407 )
2017
23
Effects of L-carnitine supplementation on biomarkers of oxidative stress, antioxidant capacity and lipid profile, in patients with pemphigus vulgaris: a randomized, double-blind, placebo-controlled trial. ( 28832573 )
2017
24
Pregnancy outcome after rituximab treatment before conception in patients affected by severe pemphigus vulgaris/superficialis. ( 28079925 )
2017
25
Relieving Pain in Oral Lesions of Pemphigus Vulgaris Using the Non-ablative, Non-thermal, CO2 Laser Therapy (NTCLT): Preliminary Results of a Novel Approach. ( 28912937 )
2017
26
Alopecia developed in a transitional case from pemphigus foliaceus to pemphigus vulgaris. ( 28681532 )
2017
27
Th1 polarizing I^I'-T cells and Scavenger Receptors contribute to the pathogenesis of Pemphigus Vulgaris. ( 28815581 )
2017
28
Concomitant pemphigus vulgaris and pemphigoid gestationis: a case report and review of the literature. ( 26990471 )
2016
29
Confirmation of association between Lewis blood group antigens and secretor status in pemphigus vulgaris. ( 27488459 )
2016
30
Temporal course of avascular femoral head necrosis in patients with pemphigus vulgaris. ( 27767268 )
2016
31
A Comparative Effectiveness Research of Azathioprine and Cyclophosphamide on the Clinical and Serological Response in Pemphigus Vulgaris. ( 27512188 )
2016
32
Oral Pemphigus Vulgaris In A Pediatric Patient. ( 28712257 )
2016
33
Unusual Histological Evidence of Dysplasia in a Case of Oral Pemphigus Vulgaris: A Potential Diagnostic Challenge. ( 27305938 )
2016
34
Pemphigus Vulgaris: How to Perform an Oral Biopsy Properly? ( 28005817 )
2016
35
Endoplasmic Reticulum stress is associated with the pathogenesis of Pemphigus Vulgaris. ( 27060358 )
2016
36
Evaluation of Pharyngo-Oesophageal Involvement in Pemphigus Vulgaris and its Correlation with Disease Activity. ( 27167757 )
2016
37
Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes. ( 27346727 )
2016
38
Pemphigus vulgaris and blood group antigens: no relationship. ( 27334804 )
2016
39
Oral pemphigus vulgaris: A case report with direct immunofluorescence study. ( 27721634 )
2016
40
Mucocutaneous Diseases: Oral Lichen Planus, Mucous Membrane Pemphigoid and Pemphigus Vulgaris. ( 28742296 )
2016
41
Crescendo response to rituximab in oral pemphigus vulgaris: a case with 7-year follow-up. ( 27061201 )
2016
42
A possible interaction between periostin and CD163+ skin-resident macrophages in pemphigus vulgaris and bullous pemphigoid. ( 27501402 )
2016
43
Risk factors in patients with oral pemphigus vulgaris: a case-control study. ( 27148665 )
2016
44
Atypical Tzanck smear findings in pemphigus vulgaris. ( 26841121 )
2016
45
Induction of T regulatory cells by the superagonistic anti-CD28 antibody D665 leads to decreased pathogenic IgG autoantibodies against desmoglein 3 in a HLA-transgenic mouse model of pemphigus vulgaris. ( 26661498 )
2016
46
Disseminated Strongyloidiasis in an Immunodeficient Patient (Pemphigus Vulgaris) Due to Corticosteroid Therapy: A Case Report. ( 28127349 )
2016
47
Koebner phenomenon in pemphigus vulgaris patients. ( 27872890 )
2016
48
Determinants of VH1-46 Cross-Reactivity to Pemphigus Vulgaris Autoantigen Desmoglein 3 and Rotavirus Antigen VP6. ( 27402694 )
2016
49
Successful treatment of oral pemphigus vulgaris in an insulin-dependant geriatric patient. ( 26108158 )
2016
50
Identification of a Functional Risk Variant for Pemphigus Vulgaris in the ST18 Gene. ( 27148741 )
2016

Variations for Pemphigus Vulgaris

Expression for Pemphigus Vulgaris

Search GEO for disease gene expression data for Pemphigus Vulgaris.

Pathways for Pemphigus Vulgaris

GO Terms for Pemphigus Vulgaris

Cellular components related to Pemphigus Vulgaris according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.85 CDH1 DSC3 DSG1 DSG2 DSG3 DSG4
2 cell-cell junction GO:0005911 9.77 DSC3 DSG1 DSG2 DSP JUP
3 intermediate filament GO:0005882 9.73 DSP DST JUP
4 intercalated disc GO:0014704 9.65 DSG2 DSP JUP
5 lateral plasma membrane GO:0016328 9.62 CDH1 DSG1 DSG2 JUP
6 cytoplasmic side of plasma membrane GO:0009898 9.61 CDH1 DSG1 JUP
7 cornified envelope GO:0001533 9.56 DSC3 DSG1 DSG2 DSG3 DSG4 DSP
8 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.55 HLA-DRB1 HLA-G
9 fascia adherens GO:0005916 9.52 DSP JUP
10 catenin complex GO:0016342 9.51 CDH1 JUP
11 hemidesmosome GO:0030056 9.49 DST JUP
12 desmosome GO:0030057 9.23 DSC3 DSG1 DSG2 DSG3 DSG4 DSP
13 integral component of membrane GO:0016021 10.24 CDH1 DSC3 DSG1 DSG2 DSG3 DSG4
14 membrane GO:0016020 10.22 CDH1 DSC3 DSG1 DSG2 DSG3 DSG4
15 extracellular exosome GO:0070062 10.11 CDH1 DSG1 DSG2 DSG3 DSP DST
16 plasma membrane GO:0005886 10.07 CDH1 DSC3 DSG1 DSG2 DSG3 DSG4

Biological processes related to Pemphigus Vulgaris according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.86 CDH1 DSC3 DSG1 DSG2 DSG3 DSG4
2 single organismal cell-cell adhesion GO:0016337 9.72 CDH1 DSG1 DSG4 DSP JUP
3 adherens junction organization GO:0034332 9.63 CDH1 DSP JUP
4 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.63 CDH1 DSC3 DSG1 DSG2 DSG3 DSG4
5 regulation of heart rate by cardiac conduction GO:0086091 9.61 DSG2 DSP JUP
6 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.58 DSG2 DSP JUP
7 response to progesterone GO:0032570 9.56 DSG1 DSG2
8 keratinization GO:0031424 9.56 DSC3 DSG1 DSG2 DSG3 DSG4 DSP
9 establishment of protein localization to plasma membrane GO:0090002 9.55 CDH1 JUP
10 negative regulation of T cell proliferation GO:0042130 9.54 HLA-DRB1 HLA-G
11 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 9.54 DSG2 DSP JUP
12 maternal process involved in female pregnancy GO:0060135 9.52 DSG1 DSG2
13 intermediate filament cytoskeleton organization GO:0045104 9.51 DSP DST
14 desmosome organization GO:0002934 9.49 DSG2 DSP
15 cellular response to indole-3-methanol GO:0071681 9.48 CDH1 JUP
16 cornification GO:0070268 9.23 DSC3 DSG1 DSG2 DSG3 DSG4 DSP

Molecular functions related to Pemphigus Vulgaris according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.5 CDH1 DSC3 DSG1 DSG2 DSG3 DSG4
2 cell adhesion molecule binding GO:0050839 9.46 CDH1 DSG2 DSP JUP
3 peptide antigen binding GO:0042605 9.32 HLA-DRB1 HLA-G
4 gamma-catenin binding GO:0045295 9.26 CDH1 DSG1
5 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 8.8 DSG2 DSP JUP

Sources for Pemphigus Vulgaris

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16 ExPASy
18 FMA
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34 ICD10 via Orphanet
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