Search: 
MCID: PNL012
MIFTS: 47

Penile Cancer malady

Cancer category
10 genes, 123 related diseases, clinical trials.

Summaries for Penile Cancer

about this section
Sources:
33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Penile Cancer, also known as malignant neoplasm of penis, part unspecified, is related to squamous cell carcinoma and adenocarcinoma. An important gene associated with Penile Cancer is FUT3 (fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)), and among its related pathways are IL-3 Signaling Pathway and Signaling by FGFR. The compounds optimax and eupatilin have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and nervous system.

Aliases & Classifications for Penile Cancer

about this section
Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
ICD10: 25


Aliases & Descriptions:

penile cancer 8
malignant neoplasm of penis, part unspecified 8
malignant neoplasm of body of penis 8
malignant tumor of body of penis 8
malignant neoplasm of penis 61
malignant tumor of penis 8
malignant penile tumor 8
penile ca 8
ca penis 8


External Ids:

Disease Ontology8 DOID:11615
ICD9CM27 187.3
ICD1025 C60.2

Related Diseases for Penile Cancer

about this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Penile Cancer family:

penile cancer, adult

Diseases related to Penile Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma30.5HRAS, CCND1, PIK3CA, CDKN2A, TP53, TERT
2adenocarcinoma29.9TP53, TERT, HRAS, PIK3CA, CDKN2A, CD82
3penile neoplasm10.2
4glans penis cancer10.2
5penis sarcoma10.2
6hypercalcemia10.2
7angiokeratoma10.2
8penile cancer, adult10.2
9lichen sclerosus10.2
10penile cancer, childhood10.2
11squamous cell papilloma10.0
12penile urethral cancer10.0
13tuberculosis10.0
14urethra cancer10.0
15vascular cancer10.0
16hepatitis c10.0KRAS
17idiopathic pulmonary fibrosis10.0TERT
18myelodysplastic syndromes10.0KRAS
19hepatitis10.0KRAS
20meningioma10.0TERT
21pulmonary fibrosis10.0TERT
22spitz nevus10.0HRAS
23plasmacytoma10.0HRAS
24ulcerative colitis10.0TP53
25kidney cancer10.0TP53
26stomach cancer10.0TP53
27pheochromocytoma10.0TERT
28rhabdomyosarcoma10.0TP53
29neuroblastoma10.0TP53
30cystadenoma10.0KRAS
31teratoma10.0TERT
32fibrosarcoma10.0CDKN1A
33liver cirrhosis10.0KRAS
34cardiofaciocutaneous syndrome10.0KRAS
35actinic keratosis10.0TP53
36gastritis10.0TP53
37ischemia10.0PIK3CA
38testicular cancer10.0KRAS
39leopard syndrome10.0HRAS
40plasma cell leukemia10.0CCND1
41parathyroid carcinoma10.0CCND1
42leiomyosarcoma10.0TP53
43liposarcoma10.0TP53
44pancreatitis10.0HRAS, KRAS
45lymphoma, malt, somatic10.0CCND1
46neurofibromatosis10.0KRAS, HRAS
47juvenile myelomonocytic leukemia10.0HRAS, KRAS
48myeloid leukemia10.0HRAS, CDKN1A
49adenocarcinoma in situ10.0CDKN2A
50anaplastic oligodendroglioma10.0CDKN2A

Graphical network of the top 20 diseases related to Penile Cancer:



Diseases related to penile cancer

Clinical Features for Penile Cancer

about this section

Drugs & Therapeutics for Penile Cancer

about this section
Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Penile Cancer

Drug clinical trials:

Search ClinicalTrials for Penile Cancer

Search NIH Clinical Center for Penile Cancer

Search CenterWatch for Penile Cancer

Genetic Tests for Penile Cancer

about this section

Anatomical Context for Penile Cancer

about this section

Animal Models for Penile Cancer or affiliated genes

about this section
Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Penile Cancer:

37 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
homeostasis/metabolism phenotype
MP:000537610.3PIK3CA
2
nervous system phenotype
MP:000363110.0HRAS, CDKN1A
3
skeleton phenotype
MP:00053909.4CCND1, CDKN1A, HRAS
4
respiratory system phenotype
MP:00053888.6CCND1, CDKN1A, KRAS, TP53
5
muscle phenotype
MP:00053698.3TP53, CDKN1A, CDKN2A
6
no phenotypic analysis
MP:00030127.8PIK3CA, CDKN2A, CDKN1A, HRAS, TP53
7
digestive/alimentary phenotype
MP:00053817.6CCND1, CDKN2A, CDKN1A, KRAS, TERT, TP53
8
cardiovascular system phenotype
MP:00053857.5CCND1, PIK3CA, CDKN1A, HRAS, KRAS, TP53
9
hematopoietic system phenotype
MP:00053977.3CDKN2A, CDKN1A, KRAS, TERT, TP53, CCND1
10
integument phenotype
MP:00107717.3CCND1, PIK3CA, CDKN2A, CDKN1A, HRAS, KRAS
11
reproductive system phenotype
MP:00053897.2CCND1, PIK3CA, CDKN2A, CDKN1A, KRAS, TERT
12
behavior/neurological phenotype
MP:00053867.1CCND1, PIK3CA, CDKN2A, CDKN1A, HRAS, KRAS
13
immune system phenotype
MP:00053877.0CCND1, PIK3CA, CDKN2A, CDKN1A, KRAS, TERT
14
cellular phenotype
MP:00053847.0CCND1, PIK3CA, CDKN2A, CDKN1A, KRAS, TERT
15
tumorigenesis
MP:00020066.9TP53, CCND1, PIK3CA, CDKN2A, CDKN1A, HRAS
16
endocrine/exocrine gland phenotype
MP:00053796.9CCND1, PIK3CA, CDKN2A, CDKN1A, HRAS, KRAS
17
growth/size phenotype
MP:00053786.9CCND1, PIK3CA, CDKN2A, CDKN1A, HRAS, KRAS
18
mortality/aging
MP:00107686.8CCND1, PIK3CA, CDKN2A, CDKN1A, HRAS, KRAS

Publications for Penile Cancer

about this section
Sources:
51PubMed
See all sources

Articles related to Penile Cancer:

(show top 50)    (show all 330)
idTitleAuthorsYear
1
Penile cancer: the importance of prevention. (24267121)
2013
2
Current concepts in penile cancer. (23667210)
2013
3
Penile nodule with inguinal lymphadenopathy: Prostatic adenocarcinoma masquerading as penile cancer. (23671367)
2013
4
Early wound complications after inguinal lymphadenectomy in penile cancer: a historical cohort study and risk-factor analysis. (23490726)
2013
5
Case of the month. Penile cancer. (23356007)
2013
6
Cytosolic phosphorylated EGFR is predictive of recurrence in early stage penile cancer patients: a retropective study. (23819610)
2013
7
Whole-mount evaluation of penectomies for penile cancer: feasibility, cost and comparison to routine sectioning. (23738630)
2013
8
Atypical primary tuberculosis mimicking an advanced penile cancer. Can we rely on preoperative assessment? (23303041)
2012
9
Penile cancer. (22846487)
2012
10
Chemotherapy in penile cancer. (22654965)
2012
11
Glans-preserving surgery for superficial penile cancer. (21868748)
2012
12
The development of a supraregional network for the management of penile cancer. (22507729)
2012
13
Questionable evidence of increasing incidence of invasive penile cancer in Denmark. (22392080)
2012
14
Current and future strategies in the diagnosis and management of penile cancer. (21687574)
2011
15
Human papillomavirus infection induces NF-I_B activation in cervical cancer: A comparison with penile cancer. (22870130)
2011
16
Penile cancer--update. (20691880)
2010
17
Surgery: Is lymphadenectomy necessary for high-risk penile cancer? (20949651)
2010
18
Neoadjuvant paclitaxel, ifosfamide, and cisplatin chemotherapy for metastatic penile cancer: a phase II study. (20625118)
2010
19
Prognostic factors in penile cancer. (20691887)
2010
20
A new neoadjuvant chemotherapy regimen for penile cancer with nodal metastases: a step forward. (19062154)
2009
21
Identifying the needs of penile cancer sufferers: a systematic review of the quality of life, psychosexual and psychosocial literature in penile cancer. (19664235)
2009
22
Activity and toxicity of paclitaxel in pretreated metastatic penile cancer patients. (19262371)
2009
23
The value of squamous cell carcinoma antigen in the prognostic evaluation, treatment monitoring and followup of patients with penile cancer. (18801542)
2008
24
Predicting pelvic lymph node metastases in penile cancer patients: a comparison of computed tomography, Cloquet's node, and disease burden of inguinal lymph nodes. (18268397)
2008
25
The role of radiation therapy after incomplete resection of penile cancer. (19016034)
2008
26
Contemporary management of penile cancer. (18540936)
2008
27
Sentinel lymph node biopsy in penile cancer: a comparative study using modified inguinal dissection. (19111077)
2008
28
Vacuum-assisted closure versus conventional wound care in the treatment of wound failures following inguinal lymphadenectomy for penile cancer: a retrospective study. (17207916)
2007
29
Incidence trends in primary malignant penile cancer. (17826651)
2007
30
Re: Regional lymph node staging using lymphotropic nanoparticle enhanced magnetic resonance imaging with ferumoxtran-10 in patients with penile cancer. (16469648)
2006
31
18F-FDG PET/CT for staging of penile cancer. (16157528)
2005
32
Sexual function after partial penectomy for penile cancer. (16360459)
2005
33
Extended lymphadenectomy in penile cancer. (15780162)
2005
34
EAU guidelines on penile cancer. (12234502)
2002
35
Parathyroid hormone related protein producing penile cancer. (11743321)
2002
36
Risk factors for penile cancer: results of a population-based case-control study in Los Angeles County (United States). (11405332)
2001
37
Penile cancer and human papilloma virus (HPV) in a human immunodeficiency virus (HIV)-infected patient. (11338884)
2001
38
Penile cancer--surgical treatment of the primary tumor. (12087954)
2001
39
Lymphoscintigraphy for penile cancer. (10737513)
2000
40
Penile cancer among patients with genital lichen sclerosus. (10570372)
1999
41
Brachytherapy for penile cancer using silicon mold. (8978588)
1997
42
Neonatal circumcision does not protect against penile cancer. (8605491)
1996
43
Serum antibodies to HPV 16 virus-like particles are not associated with penile cancer in Chinese males. (8733916)
1996
44
Penile cancer associated with an artificial penile nodule. (7817690)
1994
45
Quality of life in patients treated for penile cancer. A follow-up study. (7827818)
1994
46
Hyperthermotherapy added to the multidisciplinary therapy for penile cancer. (8379345)
1993
47
Penile cancer. Clinical presentation, diagnosis, and staging. (1574815)
1992
48
Penile cancer and smoking. (3122997)
1988
49
Penile cancer. Aspiration biopsy cytology for staging. (3742471)
1986
50
Radiotherapy in the treatment of the primary tumor in penile cancer. (6031342)
1967

Genetic Variations for Penile Cancer

about this section

Expression for genes affiliated with Penile Cancer

about this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Penile Cancer

Search GEO for disease gene expression data for Penile Cancer.

Pathways for genes affiliated with Penile Cancer

about this section
Sources:
38NCBI BioSystems Database, 54Reactome, 60Tocris Bioscience, 52QIAGEN, 12EMD Millipore, 30KEGG, 53R&D Systems, 50PharmGKB
See all sources

Pathways related to Penile Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
IL-3 Signaling Pathway38
10.2HRAS
2
Signaling by FGFR54
Hide members
9.8HRAS, KRAS
3
FGFR2c ligand binding and activation54
Hide members
9.8KRAS, HRAS
4
mTOR Pathway60
Hide members
9.7PIK3CA, HRAS
5
SHC-mediated signalling54
Hide members
9.4PIK3CA, HRAS, KRAS
6
Tie2 Signaling54
9.4PIK3CA, HRAS, KRAS
7
Cell surface interactions at the vascular wall54
9.4PIK3CA, HRAS, KRAS
8
Signaling by FGFR1 mutants54
Hide members
9.4PIK3CA, HRAS, KRAS
9
Apoptosis Pathway60
Hide members
9.4PIK3CA, HRAS, KRAS
10
GPCR Pathway52
Hide members
9.3TP53, HRAS
11
Development A3 receptor signaling
Hide members
9.2HRAS, PIK3CA, CCND1
12
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
9.0TP53, KRAS, HRAS
13
Fc epsilon receptor (FCERI) signaling54
Hide members
8.9PIK3CA, CDKN1A, HRAS, KRAS
14
PIP3 activates AKT signaling54
Hide members
8.9PIK3CA, CDKN1A, HRAS, KRAS
15
Signaling by the B Cell Receptor (BCR)54
Hide members
8.9KRAS, HRAS, CDKN1A, PIK3CA
16
Development Endothelin-1/EDNRA signaling
Hide members
8.9KRAS, HRAS, PIK3CA, CCND1
17
Development Prolactin receptor signaling
Hide members
8.9KRAS, HRAS, PIK3CA, CCND1
18
Akt Signaling Pathway 53
8.8CDKN1A, KRAS, TP53
19
AMPK signaling38
8.8PIK3CA, CDKN1A, TP53
20
Transcription Androgen Receptor nuclear signaling
Hide members
8.8CCND1, PIK3CA, CDKN1A, HRAS
21
Small cell lung cancer30
8.7TP53, PIK3CA, CCND1
22
GADD45 Pathway52
8.7TP53, CDKN1A, CCND1
23
DNA damage ATM/ATR regulation of G1/S checkpoint12
8.7TP53, CDKN1A, CCND1
24
miRNAs involved in DDR38
8.7TP53, CDKN1A, CCND1
25
TP53 network38
8.6TP53, CDKN1A, CDKN2A
26
Transcription P53 signaling pathway
Hide members
8.6TP53, CDKN1A, CDKN2A
27
Cell cycle30
Hide members
8.6CDKN2A, CDKN1A, TP53
28
Development HGF signaling pathway12
Hide members
8.5PIK3CA, HRAS, KRAS, TP53
29
Glioma30
Hide members
8.5CDKN1A, HRAS, KRAS, TP53
30
Thyroid cancer30
8.4TP53, KRAS, HRAS, CCND1
31
Prostate Cancer38
8.4TP53, HRAS, PIK3CA, CCND1
32
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways53
Hide members
8.4CCND1, PIK3CA, CDKN1A, HRAS, KRAS
33
Senescence and Autophagy38
8.3CDKN2A, CDKN1A, HRAS, TP53
34
Hepatitis C30
8.1PIK3CA, CDKN1A, HRAS, KRAS, TP53
35
Cyclins and Cell Cycle Regulation52
Hide members
8.1TP53, CDKN1A, CDKN2A, CCND1
36
Wnt Signaling Pathway38
Hide members
8.1CCND1, CDKN2A, CDKN1A, TP53
37
Development IGF-RI signaling12
Hide members
7.9CCND1, PIK3CA, CDKN1A, HRAS, TP53
38
Glioblastoma Multiforme52
7.7CCND1, CDKN2A, CDKN1A, HRAS, TP53
39
Proteoglycans in cancer30
7.6CCND1, PIK3CA, CDKN1A, HRAS, KRAS, TP53
40
Endometrial cancer30
Hide members
7.6CCND1, PIK3CA, CDKN1A, HRAS, KRAS, TP53
41
ErbB signaling pathway30
Hide members
7.6CCND1, PIK3CA, CDKN1A, HRAS, KRAS, TP53
42
Toll-like receptor signaling pathway38
Hide members
7.6CCND1, PIK3CA, CDKN1A, HRAS, KRAS, TP53
43
PI3K-Akt signaling pathway30
7.6CCND1, PIK3CA, CDKN1A, HRAS, KRAS, TP53
44
p53 signaling pathway30
Hide members
7.5CCND1, CDKN2A, CD82, CDKN1A, TP53
45
Integrated Pancreatic Cancer Pathway38
7.4CCND1, PIK3CA, CD82, CDKN1A, KRAS, TP53
46
Viral carcinogenesis30
6.9CCND1, PIK3CA, CDKN2A, CDKN1A, HRAS, KRAS
47
MicroRNAs in cancer30
6.9CCND1, PIK3CA, CDKN2A, CDKN1A, HRAS, KRAS
48
Pathways in cancer30
6.9CCND1, PIK3CA, CDKN2A, CDKN1A, HRAS, KRAS
49
Chronic myeloid leukemia30
Hide members
6.9TP53, CCND1, PIK3CA, CDKN2A, CDKN1A, HRAS
50
HTLV-I infection30
6.6CCND1, PIK3CA, CDKN2A, CDKN1A, HRAS, KRAS

Compounds for genes affiliated with Penile Cancer

about this section
Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 2BitterDB, 24HMDB
See all sources

Compounds related to Penile Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 104)
idCompoundScoreTop Affiliating Genes
1optimax459.5CDKN1A, CCND1
2eupatilin459.2CDKN1A, CCND1
3erlotinib45 50 1111.1PIK3CA, CCND1, KRAS
4gefitinib45 50 1111.1KRAS, CDKN1A, CCND1, PIK3CA
5bromodeoxyuridine459.0HRAS, CDKN1A, PIK3CA, CCND1
6depsipeptide458.9TP53, CDKN2A, CCND1
7acnu458.9TP53, CDKN2A, CDKN1A
8hpvs458.9TP53, CDKN2A, CDKN1A
9paraffin458.9CD82, TERT, CDKN1A, KRAS, HRAS
10lovastatin45 50 60 29 1112.9CCND1, CDKN2A, HRAS, CDKN1A
11imatinib45 50 1110.9KRAS, PIK3CA, CDKN1A, CCND1
12temozolomide45 119.8TP53, CDKN2A, CDKN1A
13o6-methylguanine458.8TP53, KRAS, CDKN2A
14sulindac45 119.7CDKN1A, HRAS, CCND1, TP53
15pd 98,059458.7PIK3CA, CCND1, TERT, HRAS, CDKN1A
16indole-3-carbinol458.7CDKN1A, CCND1, TP53
17gemcitabine45 50 1110.7TP53, HRAS, CDKN1A, CCND1
18irinotecan45 50 1110.6KRAS, CDKN1A, CDKN2A, TP53
19gtp45 299.5PIK3CA, CDKN1A, HRAS, KRAS, CDKN2A
20agar458.5CCND1, PIK3CA, HRAS, CDKN2A, CDKN1A
21camptothecin45 60 1110.5CDKN1A, TERT, TP53, CDKN2A
22olomoucine45 119.5CDKN1A, CDKN2A, TP53, CCND1
23rapamycin458.5TERT, KRAS, HRAS, CCND1, PIK3CA, CDKN1A
24wortmannin458.4CCND1, CDKN1A, HRAS, KRAS, TERT, PIK3CA
25docetaxel45 50 60 1111.4PIK3CA, CDKN2A, TP53, CDKN1A
26roscovitine458.4CDKN2A, TP53, CDKN1A, CCND1
27flavopiridol45 119.4TP53, CDKN1A, CCND1, CDKN2A
285-aza-2deoxycytidine458.3TERT, TP53, CDKN1A, CDKN2A
29adpribose458.3PIK3CA, TERT, TP53, CDKN1A, CCND1
30mg 13245 609.3TP53, CCND1, CDKN2A, CDKN1A
31genistein45 29 60 2 11 2413.2CCND1, PIK3CA, CDKN1A, HRAS, TERT, CDKN2A
32thymidylate458.1CDKN1A, TERT, CCND1, CDKN2A, TP53
33adriamycin458.1CCND1, TP53, TERT, CDKN1A, CDKN2A
34threonine458.1CCND1, PIK3CA, TERT, CDKN2A, CDKN1A, HRAS
35n acetylcysteine458.1CDKN1A, TERT, TP53, CDKN2A, CCND1
36thymidine45 249.0TERT, HRAS, PIK3CA, CCND1, TP53, CDKN1A
375fluorouracil457.9TERT, TP53, CDKN1A, PIK3CA, KRAS, CDKN2A
38crcs457.9TP53, CCND1, PIK3CA, CDKN2A, KRAS, HRAS
39arsenite45 248.7CDKN2A, CDKN1A, CCND1, PIK3CA, TP53, TERT
40progesterone45 60 29 11 2411.7TP53, PIK3CA, HRAS, CDKN1A, CCND1, CDKN2A
41ly294002457.7TP53, CCND1, TERT, HRAS, KRAS, CDKN1A
42tyrosine457.6CD82, CDKN1A, PIK3CA, CCND1, HRAS, KRAS
43h2o2457.5TP53, TERT, HRAS, KRAS, CDKN1A, CDKN2A
44doxorubicin45 50 119.4CDKN1A, HRAS, TERT, CCND1, CDKN2A, PIK3CA
45oligonucleotide457.4KRAS, HRAS, CCND1, CDKN1A, TP53, TERT
46paclitaxel45 50 119.1KRAS, HRAS, TP53, CCND1, PIK3CA, CDKN2A
47cisplatin45 50 60 1110.0PIK3CA, CDKN2A, CDKN1A, HRAS, TP53, KRAS
48vegf457.0CDKN1A, TERT, TP53, CCND1, PIK3CA, CDKN2A
49retinoic acid45 248.0CDKN2A, KRAS, HRAS, CDKN1A, PIK3CA, CCND1
50serine457.0HRAS, CCND1, PIK3CA, CDKN2A, TP53, TERT

GO Terms for genes affiliated with Penile Cancer

about this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Penile Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase holoenzyme complexGO:0003079.4CDKN1A, CCND1
2nuclear bodyGO:0166049.0TP53, CDKN2A
3nucleoplasmGO:0056547.4TP53, TERT, CDKN1A, CDKN2A, CCND1

Biological processes related to Penile Cancer according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of Rac protein signal transductionGO:03502210.1KRAS, HRAS
2regulation of synaptic transmission, GABAergicGO:03222810.1KRAS, HRAS
3striated muscle cell differentiationGO:05114610.1HRAS, KRAS
4regulation of long-term neuronal synaptic plasticityGO:0481699.9HRAS, KRAS
5response to organonitrogen compoundGO:0102439.8CCND1, CDKN1A
6response to corticosterone stimulusGO:0514129.7CDKN1A, CCND1
7leukocyte migrationGO:0509009.7KRAS, HRAS, PIK3CA
8insulin receptor signaling pathwayGO:0082869.6KRAS, HRAS, PIK3CA
9positive regulation of protein phosphorylationGO:0019349.6KRAS, HRAS, CCND1
10mitotic cell cycle arrestGO:0718509.5TP53, CDKN1A
11negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:0457369.5CDKN2A, CDKN1A
12cellular senescenceGO:0903989.5CDKN2A, CDKN1A, HRAS
13mitotic G1 DNA damage checkpointGO:0315719.4CCND1, TP53
14negative regulation of phosphorylationGO:0423269.4CDKN1A, CDKN2A
15response to X-rayGO:0101659.3TP53, CCND1
16fibroblast growth factor receptor signaling pathwayGO:0085439.3PIK3CA, CDKN1A, HRAS, KRAS
17Fc-epsilon receptor signaling pathwayGO:0380959.3PIK3CA, CDKN1A, HRAS, KRAS
18epidermal growth factor receptor signaling pathwayGO:0071739.3KRAS, HRAS, CDKN1A, PIK3CA
19neurotrophin TRK receptor signaling pathwayGO:0480119.3PIK3CA, CDKN1A, HRAS, KRAS
20positive regulation of cell cycle arrestGO:0711589.3CDKN2A, TP53
21intrinsic apoptotic signaling pathwayGO:0971939.2CDKN1A, HRAS, TP53
22positive regulation of reactive oxygen species metabolic processGO:20003799.2TP53, CDKN1A
23replicative senescenceGO:0903999.1TP53, TERT, CDKN2A
24cellular response to ionizing radiationGO:0714798.9TP53, CDKN1A
25negative regulation of cell growthGO:0303088.9CDKN2A, CDKN1A, TP53
26response to DNA damage stimulusGO:0069748.8CCND1, CDKN1A, TP53
27blood coagulationGO:0075968.8TP53, KRAS, HRAS, PIK3CA
28innate immune responseGO:0450878.8PIK3CA, CDKN1A, HRAS, KRAS
29cell cycle arrestGO:0070508.6TP53, HRAS, CDKN1A, CDKN2A
30negative regulation of cell proliferationGO:0082858.6CDKN2A, CDKN1A, HRAS, TP53
31Ras protein signal transductionGO:0072658.3TP53, KRAS, HRAS, CDKN1A, CDKN2A

Molecular functions related to Penile Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.4CDKN2A, CDKN1A
2MDM2/MDM4 family protein bindingGO:0973718.9CDKN2A, TP53
3protein bindingGO:0055155.8CCND1, PIK3CA, CDKN2A, CD82, CDKN1A, HRAS

Products for genes affiliated with Penile Cancer

about this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Penile Cancer

about this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
Browse MalaCards: 1-9 | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z