MCID: PNL012
MIFTS: 54

Penile Cancer

Categories: Cancer diseases, Reproductive diseases, Rare diseases

Aliases & Classifications for Penile Cancer

MalaCards integrated aliases for Penile Cancer:

Name: Penile Cancer 12 14
Penis Carcinoma 12 14 69
Penile Neoplasms 42 69
Penile Neoplasm 12 14
Malignant Neoplasm of Body of Penis 12
Malignant Neoplasm of Penis 69
Malignant Penile Tumor 12
Carcinoma of Penis 12
Neoplasm of Penis 12
Penile Carcinoma 12
Penile Tumor 12
Penile Ca 12
Ca Penis 12

Classifications:



Summaries for Penile Cancer

Disease Ontology : 12 A penile cancer that is located in the skin or tissues of the penis.

MalaCards based summary : Penile Cancer, also known as penis carcinoma, is related to penis carcinoma in situ and penile cancer, childhood. An important gene associated with Penile Cancer is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Innate Immune System and Apoptotic Pathways in Synovial Fibroblasts. The drugs Udenafil and Phosphodiesterase 5 Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include lymph node, skin and prostate, and related phenotypes are Decreased viability and homeostasis/metabolism

Wikipedia : 72 Penile cancer is a malignant growth found on the skin or in the tissues of the penis. Around 95% of... more...

Related Diseases for Penile Cancer

Diseases in the Penile Cancer family:

Penile Cancer, Adult

Diseases related to Penile Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
id Related Disease Score Top Affiliating Genes
1 penis carcinoma in situ 11.9
2 penile cancer, childhood 11.9
3 penile cancer, adult 11.9
4 penis sarcoma 10.8
5 pediatric infratentorial ependymoma 10.8 EGFR TP53
6 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 10.7 EGFR TP53
7 glycogen storage disease due to lactate dehydrogenase deficiency 10.7 PIK3CA TP53
8 lipid-cell variant infiltrating bladder urothelial carcinoma 10.7 PIK3CA TP53
9 childhood infratentorial neoplasm 10.7 EGFR TP53
10 severe pre-eclampsia 10.7 EGFR HRAS
11 bannayan-riley-ruvalcaba syndrome 10.6 EGFR PTEN
12 epidermal nevus, somatic 10.6 HRAS PIK3CA
13 breast myoepithelial neoplasm 10.6 PTEN TP53
14 fibroepithelial polyp of the anus 10.6 PIK3CA PTEN
15 breast fibrosarcoma 10.6 EGFR TP53
16 gastric papillary adenocarcinoma 10.5 HRAS PIK3CA
17 chest wall lymphoma 10.5 PTEN TP53
18 congenital mesoblastic nephroma 10.5 EGFR TP53
19 cervical adenoid cystic carcinoma 10.5 CDKN2A TP53
20 myeloid/lymphoid neoplasm associated with pdgfra rearrangement 10.5 CDKN2A EGFR
21 sublingual gland adenoid cystic carcinoma 10.5 HRAS PTEN
22 ovarian solid teratoma 10.5 HRAS PTEN
23 reese retinal dysplasia 10.5 EGFR IFNA2
24 leiomyoma cutis 10.5 CDKN2A TP53
25 extragonadal nonseminomatous germ cell tumor 10.5 EGFR TP53
26 malignant giant cell tumor of soft parts 10.5 CDKN2A EGFR
27 anal squamous cell carcinoma 10.5 CDKN2A TP53
28 malignant conjunctival melanoma 10.5 IFNA2 TP53
29 rectum squamous cell carcinoma 10.5 CDKN2A TP53
30 breast myoepitheliosis 10.4 CDKN2A TP53
31 ritter's disease 10.4 CDKN2A TP53
32 coccidiosis 10.4 CDKN2A TP53
33 uterine corpus adenofibroma 10.4 HRAS TP53
34 pancreatic serous cystic neoplasm 10.4 EGFR PIK3CA TP53
35 duodenum cancer 10.4 CDKN2A TP53
36 olfactory neuroblastoma 10.4 EGFR HRAS TP53
37 penis paget's disease 10.4 CDKN2A TP53
38 fibrous meningioma 10.4 CDKN2A HRAS
39 stenosis of lacrimal punctum 10.4 EGFR HRAS PIK3CA
40 chorioangioma 10.4 EGFR HRAS PIK3CA
41 lymphopenia 10.4 EGFR PTEN TP53
42 breast adenoid cystic carcinoma 10.4 EGFR HRAS PIK3CA
43 early congenital syphilis 10.4 CRP EGFR HRAS
44 arteritic anterior ischemic optic neuropathy 10.4 EGFR HRAS TP53
45 occupational dermatitis 10.4 EGFR HRAS PIK3CA
46 non-distal trisomy 10q 10.4 EGFR HRAS TP53
47 gorham's disease 10.4 EGFR HRAS PIK3CA
48 retinal detachment 10.4 CDKN2A TP53
49 juvenile astrocytoma 10.4 EGFR PTEN TP53
50 larynx carcinoma in situ 10.4 CDKN2A TP53

Graphical network of the top 20 diseases related to Penile Cancer:



Diseases related to Penile Cancer

Symptoms & Phenotypes for Penile Cancer

GenomeRNAi Phenotypes related to Penile Cancer according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.72 EGFR HRAS PIK3CA
2 Decreased viability GR00221-A-1 9.72 EGFR HRAS PIK3CA CDKN2A
3 Decreased viability GR00221-A-2 9.72 HRAS PIK3CA
4 Decreased viability GR00221-A-3 9.72 CDKN2A HRAS
5 Decreased viability GR00221-A-4 9.72 EGFR PIK3CA CDKN2A

MGI Mouse Phenotypes related to Penile Cancer:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.09 SCN10A TP53 APP CDKN2A CRP EGFR
2 cardiovascular system MP:0005385 10.06 CDKN2A CRP EGFR HRAS PIK3CA PTEN
3 integument MP:0010771 10.01 PTEN SCN10A TP53 APP CDKN2A EGFR
4 nervous system MP:0003631 9.86 APP CDKN2A EGFR HRAS PIK3CA PTEN
5 muscle MP:0005369 9.85 APP CDKN2A EGFR PIK3CA PTEN TP53
6 neoplasm MP:0002006 9.8 CDKN2A EGFR HRAS PIK3CA PTEN TP53
7 no phenotypic analysis MP:0003012 9.7 APP CDKN2A EGFR HRAS PIK3CA SCN10A
8 pigmentation MP:0001186 9.26 CDKN2A EGFR PTEN TP53
9 respiratory system MP:0005388 9.1 CDKN2A EGFR HRAS PTEN SCN10A TP53

Drugs & Therapeutics for Penile Cancer

Drugs for Penile Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 139)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Udenafil Approved, Investigational Phase 4 268203-93-6 6918523
2 Phosphodiesterase 5 Inhibitors Phase 4,Phase 3,Phase 2
3 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2
4 Coagulants Phase 4
5 Hemostatics Phase 4
6
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
7
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
8
Ifosfamide Approved Phase 3,Phase 2 3778-73-2 3690
9
Mechlorethamine Approved Phase 3,Phase 2 51-75-2 4033
10
Paclitaxel Approved, Vet_approved Phase 3,Phase 2 33069-62-4 36314
11
Clonidine Approved Phase 3 4205-90-7 2803
12
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
13
Epinephrine Approved, Vet_approved Phase 3 51-43-4 5816
14
Propofol Approved, Investigational, Vet_approved Phase 3 2078-54-8 4943
15 Racepinephrine Approved Phase 3
16
Ropivacaine Approved Phase 3 84057-95-4 71273 175805
17
Tadalafil Approved, Investigational Phase 3 171596-29-5 110635
18
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
19 tannic acid Approved, Nutraceutical Phase 3
20 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
21 Liver Extracts Phase 3,Phase 2,Phase 1
22 HIV Protease Inhibitors Phase 3,Phase 2
23
protease inhibitors Phase 3,Phase 2
24 Adjuvants, Anesthesia Phase 3
25 Analgesics Phase 3,Phase 2
26 Analgesics, Opioid Phase 3
27 Anesthetics Phase 3,Phase 1,Phase 2
28 Anesthetics, General Phase 3
29 Anesthetics, Intravenous Phase 3
30 Central Nervous System Depressants Phase 3,Phase 1,Phase 2
31 Narcotics Phase 3
32 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
33 Vaccines Phase 3,Phase 2,Phase 1
34 Neurotransmitter Agents Phase 3
35 Albumin-Bound Paclitaxel Phase 3,Phase 2
36 Alkylating Agents Phase 3,Phase 2,Phase 1
37 Antimitotic Agents Phase 3,Phase 2
38 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
39 Isophosphamide mustard Phase 3,Phase 2
40 Adrenergic Agents Phase 3
41 Adrenergic Agonists Phase 3
42 Adrenergic alpha-2 Receptor Agonists Phase 3
43 Adrenergic alpha-Agonists Phase 3
44 Adrenergic beta-Agonists Phase 3
45 Anesthetics, Local Phase 3,Phase 1,Phase 2
46 Anti-Asthmatic Agents Phase 3
47 Antiemetics Phase 3
48 Antihypertensive Agents Phase 3
49 Anti-Inflammatory Agents Phase 3
50 Antineoplastic Agents, Hormonal Phase 3

Interventional clinical trials:

(show top 50) (show all 72)

id Name Status NCT ID Phase Drugs
1 The Efficacy of Penile Rehabilitation Using Udenafil After Total Mesorectal Excision of Rectal Cancer Completed NCT01421940 Phase 4 Placebo drug;Udenafil
2 Effect of TachoSil® on Incidence of Symptomatic and Radiographic Lymphoceles After Extended Pelvic Lymph Node Dissection in Prostate and Bladder Cancer. Completed NCT02001857 Phase 4 1 TachoSil hemostatic sponge (9,5 cm x 4,8 cm) placed on each side on the external iliac artery.
3 Concurrent Chemoradiation Versus Wide Pelvic Lymphadenectomy for Advanced Rectal Cancer Unknown status NCT00154752 Phase 3
4 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
5 Evaluating the Effect of the VCD on Erectile Function and Penile Length Post RRP Completed NCT00177125 Phase 3
6 Pd-103 Dose De-Escalation for Early Stage Prostate Cancer: A Prospective Randomized Trial Completed NCT00247312 Phase 3
7 Efficacy and Tolerability Study of V501 in Japanese Males (V501-122) Completed NCT01862874 Phase 3
8 Evaluate Use of Caudal Nerve Blocks in Adult Penile Prosthesis Recruiting NCT02740127 Phase 3 Ropivacaine;Epinephrine;Decadron;Clonidine;Propofol
9 International Penile Advanced Cancer Trial (International Rare Cancers Initiative Study) Not yet recruiting NCT02305654 Phase 3 Paclitaxel;Ifosfamide;Cisplatin
10 Can Tadalafil Maintain Erectile Function In Patients Treated With Radiotherapy For Prostate Cancer? Terminated NCT00215631 Phase 3 tadalafil
11 External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases Unknown status NCT00637637 Phase 2 indinavir sulfate;ritonavir
12 Role of Low-intensity Shock Wave Therapy in Penile Rehabilitation Post Nerve Sparing Radical Cysto-prostatectomy Unknown status NCT02422277 Phase 2 PDE-5 inhibitors group
13 Irinotecan and Cisplatin in Treating Patients With Locally Advanced or Metastatic Penile Cancer Completed NCT00066391 Phase 2 cisplatin;irinotecan hydrochloride
14 Neoadjuvant Chemotherapy for Patients With Squamous Cell Carcinoma of the Penis Completed NCT00512096 Phase 2 Ifosfamide;Paclitaxel (Taxol);Cisplatin
15 A Trial of Cabazitaxel Chemotherapy in Relapsed Locally Advanced &/or Metastatic Carcinoma of the Penis Completed NCT03114254 Phase 2 Cabazitaxel
16 Isotretinoin Plus Interferon in Treating Patients With Recurrent Cancer Completed NCT00002506 Phase 2 isotretinoin
17 T Cell Receptor Immunotherapy Targeting HPV-16 E6 for HPV-Associated Cancers Completed NCT02280811 Phase 1, Phase 2 Fludarabine;Cyclophosphamide;Aldesleukin
18 Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Human Papillomavirus-Associated Cancers Completed NCT01585428 Phase 2 Fludarabine;Cyclophosphamide;Aldesleukin
19 Phase 2 Study of Association Gemcitabine-Cisplatin to Treat Penis Epidermoid Carcinoma Completed NCT00210041 Phase 2 Gemcitabine;Cisplatin
20 Magnetic Resonance-Guided High-Dose Brachytherapy (Short-Range Radiation Therapy) for Prostate Cancer Completed NCT00039624 Phase 2
21 Intracavernous Bone Marrow Stem-cell Injection for Post Prostatectomy Erectile Dysfunction Completed NCT01089387 Phase 1, Phase 2
22 Dacomitinib (PF-00299804) in Advanced/Metastatic Squamous Cell Carcinoma of the Penis Recruiting NCT01728233 Phase 2 Dacomitinib
23 Trial of Pembrolizumab for Advanced Penile Squamous Cell Carcinoma Recruiting NCT02837042 Phase 2 Pembrolizumab
24 An Investigational Immuno-therapy Study to Investigate the Safety and Effectiveness of Nivolumab, and Nivolumab Combination Therapy in Virus-associated Tumors Recruiting NCT02488759 Phase 1, Phase 2 Nivolumab;Ipilimumab;BMS-986016;Daratumumab
25 Study for the Evaluation of Efficacy of Pembrolizumab (MK-3475) in Patients With Rare Tumors Recruiting NCT02721732 Phase 2 Pembrolizumab
26 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
27 Trial Using Gilotrif for Advanced Penile Squamous Cell Carcinoma Recruiting NCT02541903 Phase 2 Gilotrif
28 Secured Access to Nivolumab for Adult Patients With Selected Rare Cancer Types Recruiting NCT03012581 Phase 2 Nivolumab
29 Evaluation of Lymphadenectomy and Chemotherapy TIP on Inguinal Lymph Nodes in Squamous Cell Carcinoma of the Penis Active, not recruiting NCT02817958 Phase 2 Chemotherapie TIP
30 A Phase II Trial of Vinflunine Chemotherapy in Locally-advanced and Metastatic Carcinoma of the Penis (VinCaP) Active, not recruiting NCT02057913 Phase 2 Vinflunine
31 Vaccine Therapy in Preventing Human Papillomavirus Infection in Young HIV-Positive Male Patients Who Have Sex With Males Active, not recruiting NCT01209325 Phase 2
32 S0224, Docetaxel in Treating Patients With Locally Advanced or Metastatic Penile Cancer (TERMINATED) Terminated NCT00058448 Phase 2 docetaxel
33 Study With Pazopanib and Weekly Paclitaxel in Penile Carcinoma (PAZOPEN-SOGUG) Terminated NCT02279576 Phase 2 Pazopanib;Paclitaxel
34 Efficacy and Safety of Cetuximab in Metastatic Penile Carcinoma (PENILANE) Withdrawn NCT02014831 Phase 2 Cetuximab;TIP
35 Dorsal Penile Block for Post-Robotic Prostatectomy Foley Discomfort Withdrawn NCT01565512 Phase 1, Phase 2 Bupivacaine;Saline
36 Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural Effusions Unknown status NCT00066404 Phase 1
37 Vaccine Therapy in Treating Patients With Advanced or Recurrent Cancer Completed NCT00019110 Phase 1
38 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1 entinostat
39 Cisplatin-based Chemotherapy Combined With P16_37-63 Peptide Vaccination in Patients With HPV-positive Cancers Completed NCT02526316 Phase 1
40 Chemotherapy Plus Radiation Therapy in Treating Patients With Unresectable, Residual, or Recurrent Colorectal Cancer Completed NCT00003704 Phase 1 capecitabine
41 Intravenous VEGF Trap in Treating Patients With Relapsed or Refractory Advanced Solid Tumors or Non-Hodgkin's Lymphoma Completed NCT00082823 Phase 1
42 Intravenous VEGF Trap in Treating Patients With Relapsed or Refractory Advanced Solid Tumors or Non-Hodgkin's Lymphoma Completed NCT00083213 Phase 1
43 E7 TCR T Cells With or Without PD-1 Blockade for Human Papillomavirus-Associated Cancers Recruiting NCT02858310 Phase 1 pembrolizumab;aldesleukin;fludarabine;cyclophosphamide
44 Cabozantinib-s-malate and Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Genitourinary Tumors Recruiting NCT02496208 Phase 1 Cabozantinib S-malate
45 HPV-16/18 E6/E7-Specific T Lymphocytes, Relapsed HPV-Associated Cancers, HESTIA Recruiting NCT02379520 Phase 1 Cytoxan;Fludarabine
46 A Phase II Trial of CyberKnife Stereotactic Radiosurgery to Prostate Tumors Unknown status NCT02225262
47 Videoscopic Versus Open Inguinal Lymphadenectomy for Cancer Completed NCT01526486
48 Cancer in Patients With Gabapentin (GPRD) Completed NCT01236053 Gabapentin prescriptions
49 OX-40 Protein Expression in the Sentinel Lymph Nodes of Patients With Cancer Completed NCT00900302
50 Early Intervention vs. Standard Palliative Care in Improving End-of-Life Care in Advanced Cancer Patients Completed NCT00253383

Search NIH Clinical Center for Penile Cancer

Cochrane evidence based reviews: penile neoplasms

Genetic Tests for Penile Cancer

Anatomical Context for Penile Cancer

MalaCards organs/tissues related to Penile Cancer:

39
Lymph Node, Skin, Prostate, T Cells, Bone Marrow, Liver, Bone

Publications for Penile Cancer

Articles related to Penile Cancer:

(show top 50) (show all 401)
id Title Authors Year
1
E2F1 Signalling is Predictive of Chemoresistance and Lymphogenic Metastasis in Penile Cancer: A Pilot Functional Study Reveals New Prognostic Biomarkers. ( 28753861 )
2017
2
The Patterns of Practice and Outcomes of Penile Cancer in Ontario. ( 28057403 )
2017
3
Exophytic papillary penile cancer. ( 28687155 )
2017
4
Advancements in staging and imaging for penile cancer. ( 28937510 )
2017
5
Delay to Inguinal Lymph Node Dissection Greater than 3 Months Predicts Poorer Recurrence Free Survival for Patients with Penile Cancer. ( 28652123 )
2017
6
Current Management Strategy for Penile Cancer and Future Directions. ( 28664471 )
2017
7
Advanced penile cancer with iliac lymph node involvement treated with radiation and concurrent gemcitabine. ( 28411892 )
2017
8
Immunotherapy for penile cancer. ( 28883996 )
2017
9
Serum biomarkers to predict risk of testicular and penile cancer in AMORIS. ( 28900475 )
2017
10
Long-term trends in incidence and survival of penile cancer in France. ( 28898817 )
2017
11
Contemporary management of patients with penile cancer and lymph node metastasis. ( 28401957 )
2017
12
Clinicopathologic Characteristics and Treatment Outcomes of Penile Cancer. ( 28459145 )
2017
13
Surgical treatment of advanced penile cancer. ( 28493019 )
2017
14
Subclassification of pN3 staging systems for penile cancer: Proposal for modification of the current TNM classification. ( 28578871 )
2017
15
Bilateral pelvic lymph node dissection for Chinese patients with penile cancer: a multicenter collaboration study. ( 27771796 )
2017
16
Identifying Psychosocial Distress and Stressors Using Distress-screening Instruments in Patients With Localized and Advanced Penile Cancer. ( 28499559 )
2017
17
Adjuvant pelvic radiation is associated with improved survival and decreased disease recurrence in pelvic node-positive penile cancer after lymph node dissection: A multi-institutional study. ( 28666722 )
2017
18
Contemporary survival trends in penile cancer: Results from the National Cancer Database. ( 28882672 )
2017
19
National Trends and Predictors of Locally Advanced Penile Cancer in the United States (1998-2012). ( 28866244 )
2017
20
Analysis of Knowledge Level in Brazilian Students about Human Papillomavirus Infection and Development of Penile Cancer ( 28612588 )
2017
21
Human papillomavirus, Epstein-Barr virus, and methylation status of p16(ink4a) in penile cancer. ( 28403538 )
2017
22
15 Years of penile cancer management in the United States: An analysis of the use of partial penectomy for localized disease and chemotherapy in the metastatic setting. ( 27495001 )
2016
23
Socioeconomic factors and penile cancer risk and mortality; a population-based study. ( 27373878 )
2016
24
Multimodal Therapy in the Management of Advanced Penile Cancer. ( 27717433 )
2016
25
PD-L1 expression in penile cancer: a new frontier for immune checkpoint inhibitors? ( 27436847 )
2016
26
Disparities in Penile Cancer. ( 27842330 )
2016
27
10-Year experience regarding the reliability and morbidity of radio guided lymph node biopsy in penile cancer patients and the associated radiation exposure of medical staff in this procedure. ( 27485215 )
2016
28
Preoperative peripheral plasma fibrinogen level is an independent prognostic marker in penile cancer. ( 27738342 )
2016
29
Clinical value of fluorine-18 2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in penile cancer. ( 27203206 )
2016
30
Glansectomy and Split-thickness Skin Graft for Penile Cancer. ( 27746062 )
2016
31
Incremental value of MRI for preoperative penile cancer staging. ( 27402024 )
2016
32
Expression of Programmed Death Ligand 1 in Penile Cancer Is of Prognostic Value and Associated with HPV Status. ( 27697578 )
2016
33
Advantages by using the intradermal microbubbles for sentinel lymph node detection in penile cancer. ( 27824971 )
2016
34
Penile cancer metastasizing to the breast: a case report. ( 26961850 )
2016
35
Management of Penile Cancer. ( 26802797 )
2016
36
Overexpression of Insulin-like Growth Factor-1 Receptor Is Associated With Penile Cancer Progression. ( 26905033 )
2016
37
Re: EAU Guidelines on Penile Cancer: 2014 Update. ( 27186734 )
2016
38
Radiocolloid-based dynamic sentinel lymph node biopsy in penile cancer with clinically negative inguinal lymph node: an updated systematic review and meta-analysis. ( 27577753 )
2016
39
Epidermal Growth Factor Receptor, Excision-Repair Cross-Complementation Group 1 Protein, and Thymidylate Synthase Expression in Penile Cancer. ( 26935231 )
2016
40
The Danish National Penile Cancer Quality database. ( 27822104 )
2016
41
Radiotherapy approaches for locally advanced penile cancer: neoadjuvant and adjuvant. ( 27584027 )
2016
42
Dr. Arthur L. Burnett: surgical treatment for penile cancer. ( 27785442 )
2016
43
Low-dose brachytherapy for early stage penile cancer: a 20-year single-institution study (73 patients). ( 27464910 )
2016
44
Pathophysiological basis of human papillomavirus in penile cancer: Key to prevention and delivery of more effective therapies. ( 27314890 )
2016
45
Penile cancer: Welcome changes in disease management and remaining challenges. ( 27797359 )
2016
46
Penile cancer: Prognostic value of PD-L1 status. ( 27754476 )
2016
47
A Contemporary Review of HPV and Penile Cancer. ( 26984219 )
2016
48
Organ-sparing treatment of penile cancer with interstitial pulsed-dose-rate brachytherapy. ( 27276876 )
2016
49
Establishment and characterization of a penile cancer cell line, penl1, with a deleterious TP53 mutation as a paradigm of HPVnegative penile carcinogenesis. ( 27351128 )
2016
50
Racial Disparities Differ for African Americans and Hispanics in the Diagnosis and Treatment of Penile Cancer. ( 27402373 )
2016

Variations for Penile Cancer

Cosmic variations for Penile Cancer:

9 (show all 23)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM12475 CDKN2A skin,penis,carcinoma,squamous cell carcinoma c.238C>T p.R80* 14
2 COSM10660 TP53 skin,NS,carcinoma,Merkel cell carcinoma c.818G>A p.R273H 7
3 COSM11491 TP53 skin,NS,carcinoma,Merkel cell carcinoma c.743G>C p.R248P 7
4 COSM10656 TP53 skin,NS,carcinoma,Merkel cell carcinoma c.742C>T p.R248W 7
5 COSM45765 TP53 skin,leg,carcinoma,squamous cell carcinoma c.987C>A p.T329T 7
6 COSM10863 TP53 skin,leg,carcinoma,squamous cell carcinoma c.833C>T p.P278L 7
7 COSM45114 TP53 skin,leg,carcinoma,squamous cell carcinoma c.702C>A p.Y234* 7
8 COSM1735722 RB1 skin,NS,carcinoma,Merkel cell carcinoma c.298G>A p.G100R 7
9 COSM1735721 RB1 skin,NS,carcinoma,Merkel cell carcinoma c.297G>A p.W99* 7
10 COSM214151 RB1 skin,NS,carcinoma,Merkel cell carcinoma c.585G>A p.W195* 7
11 COSM1731707 RB1 skin,NS,carcinoma,Merkel cell carcinoma c.1789C>T p.Q597* 7
12 COSM5316 PTEN skin,NS,carcinoma,Merkel cell carcinoma c.439A>T p.K147* 7
13 COSM766 PIK3CA skin,NS,carcinoma,Merkel cell carcinoma c.1636C>A p.Q546K 7
14 COSM27133 PIK3CA skin,NS,carcinoma,Merkel cell carcinoma c.1633G>C p.E545Q 7
15 COSM760 PIK3CA skin,NS,carcinoma,Merkel cell carcinoma c.1624G>A p.E542K 7
16 COSM763 PIK3CA skin,NS,carcinoma,Merkel cell carcinoma c.1633G>A p.E545K 7
17 COSM776 PIK3CA skin,NS,carcinoma,Merkel cell carcinoma c.3140A>T p.H1047L 7
18 COSM249774 PIK3CA skin,NS,carcinoma,Merkel cell carcinoma c.56G>A p.R19K 7
19 COSM573 NRAS skin,scalp,carcinoma,squamous cell carcinoma c.38G>A p.G13D 7
20 COSM521 KRAS skin,scalp,carcinoma,squamous cell carcinoma c.35G>A p.G12D 7
21 COSM554 KRAS skin,scalp,carcinoma,squamous cell carcinoma c.183A>C p.Q61H 7
22 COSM499 HRAS skin,trunk,carcinoma,squamous cell carcinoma c.182A>G p.Q61R 7
23 COSM498 HRAS skin,trunk,carcinoma,squamous cell carcinoma c.182A>T p.Q61L 7

Expression for Penile Cancer

Search GEO for disease gene expression data for Penile Cancer.

Pathways for Penile Cancer

Pathways related to Penile Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 APP CRP EGFR HRAS IFNA2 PIK3CA
2
Show member pathways
13.75 APP CDKN2A EGFR HRAS IFNA2 PTEN
3
Show member pathways
12.73 CDKN2A HRAS PIK3CA TP53
4
Show member pathways
12.71 HRAS PIK3CA PTEN TP53
5
Show member pathways
12.68 EGFR HRAS PIK3CA PTEN
6
Show member pathways
12.64 EGFR HRAS PIK3CA PTEN TP53
7 12.54 EGFR HRAS IFNA2 PIK3CA PTEN TP53
8
Show member pathways
12.5 EGFR HRAS PIK3CA TP53
9 12.48 CDKN2A EGFR HRAS PIK3CA PTEN TP53
10
Show member pathways
12.45 EGFR HRAS PIK3CA TP53
11
Show member pathways
12.44 CDKN2A EGFR HRAS PIK3CA PTEN TP53
12
Show member pathways
12.38 EGFR HRAS PIK3CA TP53
13 12.36 CDKN2A HRAS PIK3CA TP53
14
Show member pathways
12.34 EGFR HRAS PIK3CA PTEN TP53
15
Show member pathways
12.32 HRAS PIK3CA PTEN TP53
16
Show member pathways
12.25 EGFR HRAS PIK3CA TP53
17 12.23 EGFR HRAS PIK3CA TP53
18 12.22 CDKN2A HRAS PIK3CA TP53
19 12.21 CDKN2A EGFR HRAS PIK3CA PTEN TP53
20
Show member pathways
12.16 EGFR HRAS PTEN
21
Show member pathways
12.14 HRAS IFNA2 PIK3CA
22 12.11 EGFR HRAS PTEN
23
Show member pathways
12.11 EGFR HRAS PIK3CA PTEN TP53
24
Show member pathways
12.1 HRAS PIK3CA PTEN
25
Show member pathways
12.09 HRAS PIK3CA TP53
26 12.07 EGFR PTEN TP53
27
Show member pathways
12.07 EGFR HRAS PIK3CA PTEN
28
Show member pathways
12.06 HRAS PIK3CA TP53
29
Show member pathways
12.05 EGFR HRAS PIK3CA PTEN
30
Show member pathways
12.01 EGFR HRAS PIK3CA PTEN
31 11.99 EGFR PTEN TP53
32 11.99 CDKN2A PTEN TP53
33
Show member pathways
11.97 EGFR HRAS TP53
34 11.97 HRAS PIK3CA PTEN
35
Show member pathways
11.95 EGFR PIK3CA TP53
36 11.91 HRAS PIK3CA TP53
37 11.91 HRAS PIK3CA PTEN TP53
38
Show member pathways
11.88 EGFR HRAS PIK3CA
39 11.84 CDKN2A HRAS PTEN TP53
40 11.84 EGFR HRAS IFNA2 PIK3CA TP53
41 11.82 EGFR HRAS IFNA2 PIK3CA
42 11.76 PIK3CA PTEN TP53
43 11.69 CDKN2A PIK3CA TP53
44
Show member pathways
11.64 APP PIK3CA TP53
45 11.62 CDKN2A EGFR HRAS TP53
46 11.61 CDKN2A HRAS PIK3CA PTEN TP53
47
Show member pathways
11.55 EGFR HRAS PIK3CA
48 11.55 HRAS PIK3CA PTEN TP53
49 11.54 HRAS PIK3CA PTEN
50 11.49 CDKN2A EGFR TP53

GO Terms for Penile Cancer

Biological processes related to Penile Cancer according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.84 EGFR HRAS PTEN TP53
2 positive regulation of protein phosphorylation GO:0001934 9.75 APP EGFR HRAS
3 T cell receptor signaling pathway GO:0050852 9.74 HRAS PIK3CA PTEN
4 cell cycle arrest GO:0007050 9.72 CDKN2A HRAS TP53
5 negative regulation of cell proliferation GO:0008285 9.72 APP CDKN2A HRAS PTEN TP53
6 apoptotic process GO:0006915 9.63 APP CDKN2A HRAS IFNA2 PTEN TP53
7 Ras protein signal transduction GO:0007265 9.61 CDKN2A HRAS TP53
8 cellular response to gamma radiation GO:0071480 9.59 HRAS TP53
9 cellular senescence GO:0090398 9.58 CDKN2A HRAS
10 epidermal growth factor receptor signaling pathway GO:0007173 9.58 EGFR HRAS PIK3CA
11 learning or memory GO:0007611 9.54 APP EGFR PTEN
12 positive regulation of superoxide anion generation GO:0032930 9.52 CRP EGFR
13 replicative senescence GO:0090399 9.51 CDKN2A TP53
14 ERBB2 signaling pathway GO:0038128 9.43 EGFR HRAS PIK3CA
15 regulation of long-term neuronal synaptic plasticity GO:0048169 9.26 HRAS
16 phosphatidylinositol-mediated signaling GO:0048015 9.26 EGFR PIK3CA PTEN TP53
17 amyloid fibril formation GO:1990000 9.19 APP
18 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.18 PIK3CA
19 astrocyte activation GO:0048143 9.16 EGFR
20 positive regulation of gene expression GO:0010628 9.02 APP CRP HRAS PTEN TP53
21 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10 APP CDKN2A EGFR HRAS TP53

Molecular functions related to Penile Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.26 CDKN2A EGFR PTEN TP53
2 enzyme binding GO:0019899 8.92 APP EGFR PTEN TP53

Sources for Penile Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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