MCID: PPT003
MIFTS: 61

Peptic Ulcer malady

Summaries for Peptic Ulcer

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 A peptic ulcer is a sore in the lining of your stomach or your duodenum, the first part of your small intestine. a burning stomach pain is the most common symptom. the pain starts between meals or during the night briefly stops if you eat or take antacids lasts for minutes to hours comes and goes for several days or weeks peptic ulcers happen when the acids that help you digest food damage the walls of the stomach or duodenum. the most common cause is infection with a bacterium called helicobacter pylori. another cause is the long-term use of nonsteroidal anti-inflammatory medicines (nsaids) such as aspirin and ibuprofen. stress and spicy foods do not cause ulcers, but can make them worse. to see if you have an h. pylori infection, your doctor will test your blood, breath, or stool. your doctor also may look inside your stomach and duodenum by doing an endoscopy or x-ray. peptic ulcers will get worse if not treated. treatment may include medicines to reduce stomach acids or antibiotics to kill h. pylori. antacids and milk can't heal peptic ulcers. not smoking and avoiding alcohol can help. you may need surgery if your ulcers don't heal. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Peptic Ulcer, also known as acute peptic ulcer without hemorrhage and without perforation, is related to peptic ulcer perforation and gastric ulcer. An important gene associated with Peptic Ulcer is HRH2 (histamine receptor H2), and among its related pathways are Arachidonic acid metabolism and NF-kappa B signaling pathway. The drugs hyoscyamine sulfate and glycine and the compounds pge2 and pepsinogen have been mentioned in the context of this disorder. Affiliated tissues include testes, small intestine and kidney, and related mouse phenotypes are immune system and homeostasis/metabolism.

Wikipedia:63 A peptic ulcer, stomach ulcer or gastric ulcer, also known as peptic ulcer disease (PUD), is a distinct... more...

Aliases & Classifications for Peptic Ulcer

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt
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Aliases & Descriptions:

peptic ulcer 8 10 44 33 60
acute peptic ulcer without hemorrhage and without perforation 8
acute peptic ulcer with hemorrhage and perforation 8
acute peptic ulcer with hemorrhage 8


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Disease Ontology8 DOID:750
MeSH34 D010437
ICD9CM27 533
NCIt39 C3318

Related Diseases for Peptic Ulcer

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17GeneCards, 18GeneDecks
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Diseases related to Peptic Ulcer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 218)
idRelated DiseaseScoreTop Affiliating Genes
1peptic ulcer perforation31.6POMP
2gastric ulcer31.5PTGS2, S100A8, GAST, MUC5AC, CYP2C19, HRH2
3gastritis31.3S100A8, SCT, GAST, IL8
4duodenal ulcer31.1S100A8, SCT, GAST, HRH2
5duodenitis31.1ATP4A, GAST, S100A8
6dyspepsia30.9GAST, ATP4A, HRH2
7esophagitis30.8HRH2, CYP2C19, ATP4A, GAST, S100A8
8zollinger-ellison syndrome30.8SCT, GAST, HRH2
9gastroduodenitis30.8GAST
10duodenogastric reflux30.7GAST
11liver cirrhosis30.7SCT, CTSD, AKR1A1, MUC5AC, CD14, ALB
12hepatitis30.6HRH2, AKR1A1
13adenocarcinoma30.5S100A8, SCT, CTSD, GAST, MUC5AC, PTGS1
14pancreatitis30.5ALB, SCT
15peritonitis30.5ALB, CD14
16atrophic gastritis30.5S100A8, SCT, GAST, AKR1A1
17myocardial infarction30.5PTGS2, PTGS1, CD14, AKR1A1
18gastroesophageal reflux disease30.4S100A8, SCT, GAST, ATP4A, CYP2C19, HRH2
19barrett's esophagus30.4S100A8, GAST, MUC5AC, PTGS1, PTGS2
20gastric adenocarcinoma30.4S100A8, CTSD, GAST, HRH2, PTGS2
21stomach disease30.2HRH2, PTGS1, PTGS2
22hypertension30.2ALB
23acute myocardial infarction30.2CD14
24gastrinoma30.2SCT, GAST, ATP4A
25atherosclerosis30.2CDKN3, CD14, CXCL1, IL8, PTGS1, PTGS2
26inflammatory bowel disease30.0IL8
27periodontitis30.0IL8
28cholangiocarcinoma30.0PTGS2, MUC5AC, SCT
29encephalomyelitis30.0CXCL1
30acute pancreatitis30.0SCT, CD14, IL8, HRH2
31stomach cancer30.0S100A8, CTSD, GAST, HDC, MUC5AC, HRH2
32periodontal disease30.0PTGS1, IL8, CD14, S100A8
33adenoma30.0S100A8, SCT, CTSD, GAST, MUC5AC, CXCL1
34gastric outlet obstruction30.0GAST, ATP4A
35colon cancer30.0CTSD, GAST, CXCL1, PTGS1, PTGS2
36bile reflux30.0ATP4A
37ulcerative colitis30.0DEFA5, CD14, CXCL1, IL8
38pancreatic cancer30.0MUC5AC, GAST, SCT
39peptic esophagitis10.6
40active peptic ulcer disease10.6
41duodenal disease10.5
42liver disease10.4
43gastric lymphoma10.4
44esophageal disease10.3
45gallbladder disease10.3
46hiatus hernia10.3
47meckel's diverticulum10.3
48dumping syndrome10.3
49hepatitis a10.3
50islet cell tumor10.3

Graphical network of the top 20 diseases related to Peptic Ulcer:



Diseases related to peptic ulcer

Clinical Features for Peptic Ulcer

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Drugs & Therapeutics for Peptic Ulcer

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Peptic Ulcer

Search CenterWatch for Peptic Ulcer

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Peptic Ulcer

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Anatomical Context for Peptic Ulcer

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32MalaCards
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MalaCards organs/tissues related to Peptic Ulcer:

32
Testes, Small intestine, Kidney, Liver, T cells, Pancreas, Heart, Colon, Tongue, Endothelial, Ovary, Myeloid

Animal Models for Peptic Ulcer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Peptic Ulcer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.3HDC, PTGS2, PTGS1, IL8, CD14, CTSD
2MP:000537610.2SCT, ALB, PTGS2, PTGS1, HRH2, CD14
3MP:000538110.0ALB, PTGS2, PTGS1, HRH2, MUC5AC, ATP4A

Publications for Peptic Ulcer

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50PubMed
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Articles related to Peptic Ulcer:

(show top 50)    (show all 807)
idTitleAuthorsYear
1
Peptic ulcer bleeding in China: A multicenter endoscopic survey of 1006 patients. (24118892)
2014
2
Nonoperative management for perforated peptic ulcer: Who can benefit? (24393814)
2014
3
Reassessment of the predictive value of the Forrest classification for peptic ulcer rebleeding and mortality: can classification be simplified? (24218308)
2014
4
Refractory peptic ulcer disease: listen for the cause. (24269659)
2014
5
Laparoscopic repair of perforated peptic ulcer-technical tip. (23917602)
2013
6
Is peptic ulcer disease a risk factor of postherpetic neuralgia in patients with herpes zoster? (24074834)
2013
7
Lower circulating levels of chemokine CXCL10 in Helicobacter pylori-infected patients with peptic ulcer: Influence of the bacterial virulence factor CagA. (23467184)
2013
8
The risk of peptic ulcer bleeding mortality in relation to hospital admission on holidays: a cohort study on 8,222 cases of peptic ulcer bleeding. (22108453)
2012
9
Reply to: doi:10.1007/s00464-009-0765-z: Laparoscopic correction of perforated peptic ulcer: first choice? A review of literature. (21898026)
2012
10
The Peptic Ulcer Perforation (PULP) score: a predictor of mortality following peptic ulcer perforation. A cohort study. (22191386)
2012
11
The risk of oesophageal adenocarcinoma after gastrectomy for peptic ulcer disease. (22019213)
2012
12
Association between acute pancreatitis and peptic ulcer disease. (21448359)
2011
13
Hematologic and laboratory parameters in patientis with peptic ulcer bleeding treated by two modalities of endoscopic haemostasis and proton pump inhibitors. (21263414)
2011
14
Prophylactic use of omeprazole associated with a reduced risk of peptic ulcer disease among maintenance hemodialysis patients. (21401358)
2011
15
Drugs for peptic ulcer disease and GERD. (21860368)
2011
16
Changes in the localization of perforated peptic ulcer and its relation to gender and age of the patients throughout the last 45 years. (21267567)
2011
17
Prospective survey for the etiology and outcome of peptic ulcer bleeding: a community based study in southern Taiwan. (21540004)
2011
18
Peptic ulcer disease in India--a 16 year trend analysis. (21568140)
2010
19
Differences in the birth-cohort patterns of gastric cancer and peptic ulcer. (20551458)
2010
20
High-dose vs non-high-dose proton pump inhibitors after endoscopic treatment in patients with bleeding peptic ulcer: a systematic review and meta-analysis of randomized controlled trials. (20458081)
2010
21
DNA sequence analysis of cagA 3' motifs of Helicobacter pylori strains from patients with peptic ulcer diseases. (19850704)
2010
22
Perforated peptic ulcer: different ethnic, climatic and fasting risk factors for morbidity in Al-ain medical district, United Arab Emirates. (19423456)
2009
23
Proton pump inhibitors after endoscopic hemostasis in patients with peptic ulcer bleeding. (20380111)
2009
24
Neither genotype nor the gastric colonization site of Helicobacter pylori are predictive factors for the development of erosive esophagitis in patients with peptic ulcer disease, 1 year after eradication. (19918687)
2009
25
Prognostic factors in gastrointestinal bleeding due to peptic ulcer, construction of a predictive model. (19551920)
2009
26
Time trends in peptic ulcer, erosive reflux oesophagitis, gastric and oesophageal cancers in a multiracial Asian population. (19183160)
2009
27
Recent advances in peptic ulcer bleeding. (20948737)
2009
28
Refractory peptic ulcer disease. (19446258)
2009
29
Hospital based analytic study of peptic ulcer disease in patients with dyspeptic symptoms. (20071846)
2009
30
Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T cell responses. (18467372)
2008
31
Role of barium meal examination in diagnosis of peptic ulcer. (19999206)
2008
32
Hospitalization for peptic ulcer and bleeding in users of selective COX-2 inhibitors and nonselective NSAIDs with special reference to celecoxib. (18711705)
2008
33
Introducing a clinical pathway for acute peptic ulcer bleeding in general internal medicine wards. (18609139)
2008
34
The influence of the eradication of Helicobacter pylori on gastric ghrelin, appetite, and body mass index in patients with peptic ulcer disease. (19120912)
2008
35
Factors affecting mortality and morbidity in patients with peptic ulcer perforation. (17376052)
2007
36
Association between genetic polymorphisms in the cyclooxygenase-1 gene promoter and peptic ulcers in Japan. (17671743)
2007
37
H pylori infection and other risk factors associated with peptic ulcers in Turkish patients: a retrospective study. (17589905)
2007
38
Gastric epithelial anti-microbial peptides--histological correlation and influence of anatomical site and peptic ulcer disease. (15702860)
2005
39
Helicobacter pylori antigen-specific T-cell responses at gastric level in chronic gastritis, peptic ulcer, gastric cancer and low-grade mucosa-associated lymphoid tissue (MALT) lymphoma. (12814773)
2003
40
CagA antibodies in Japanese children with nodular gastritis or peptic ulcer disease. (10618065)
2000
41
Rhythmic patterns in incidence of peptic ulcer perforation over 5.5 decades in Norway. (9653578)
1998
42
Serum pepsinogen I and gastrin in peptic ulcer patients using nonsteroidal anti-inflammatory drugs. (9261614)
1997
43
Altered urinary interleukin-8/creatinine ratio in peptic ulcer disease: pathological and diagnostic implications. (8946980)
1996
44
Serum concentration of prolactin, gastrin and glycocholic acid in patient with peptic ulcer treated with ranitidine]. (11785198)
1995
45
Effect of age on gastric acid, pepsin, pepsinogen group A and gastrin secretion in peptic ulcer patients. (7959081)
1994
46
Detection and characterization of circulating immune complexes in peptic ulcer. (1490153)
1992
47
Gastric emptying after peptic ulcer surgery. Some pathophysiological mechanisms of the dumping syndrome. (7167737)
1982
48
An evaluation of the bile acid binding and antacid properties of hydrotalcite in hiatus hernia and peptic ulceration. (467092)
1979
49
Peptic ulcer in gall bladder diverticulum. (13481632)
1957
50
Peptic ulcer perforation after phenylbutazone therapy. (13199345)
1954

Genetic Variations for Peptic Ulcer

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Expression for genes affiliated with Peptic Ulcer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Peptic Ulcer

Search GEO for disease gene expression data for Peptic Ulcer.

Pathways for genes affiliated with Peptic Ulcer

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53Reactome, 12EMD Millipore, 29KEGG, 37NCBI BioSystems Database
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Pathways related to Peptic Ulcer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4CYP2C19, PTGS1, PTGS2
210.4PTGS2, IL8, CD14
310.4PTGS1, PTGS2, ALB
410.4IL8, CXCL1, CD14
510.4IL8, CXCL1, CD14
6
Cytokine production by Th17 cells in CF (Mouse model)
10.4CD14, CXCL1, IL8
7
Hide members
10.4PTGS2, PTGS1, AKR1A1

Compounds for genes affiliated with Peptic Ulcer

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44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Peptic Ulcer according to GeneCards/GeneDecks:

(show top 50)    (show all 206)
idCompoundScoreTop Affiliating Genes
1pge24410.9PTGS2
2pepsinogen4410.9GAST, HRH2, SCT, CTSD
3Acetylsalicylic acid1110.8ALB, PTGS2, PTGS1, CYP2C19
4clarithromycin44 1111.8CYP2C19, HRH2, IL8, GAST, S100A8
5ranitidine44 28 11 2413.8GAST, HRH2, CYP2C19, AKR1A1, SCT
6amoxicillin44 49 1112.8CYP2C19, S100A8, GAST, HRH2
7pantoprazole44 49 11 2413.8GAST, ATP4A, CYP2C19, HRH2
8acetaminophen44 2 49 11 2414.8CYP2C19, HRH2
9omeprazole44 28 49 11 2414.8SCT, GAST, ATP4A, HDC, HRH2, CYP2C19
10diclofenac44 28 49 1113.8ALB, PTGS2, PTGS1, HRH2, CYP2C19
11Magnesium salicylate1110.8PTGS2, ALB, PTGS1
12cimetidine44 28 1112.8SCT, GAST, AKR1A1, CYP2C19, HRH2
13lansoprazole49 44 11 2413.8GAST, ATP4A, CYP2C19, HRH2
14antipyrine44 1111.8PTGS2, ALB, PTGS1, CYP2C19
15dexamethasone44 49 28 1113.8S100A8, MUC5AC, CD14, CYP2C19, CXCL1, PTGS2
16fenoprofen28 44 1112.8PTGS2, PTGS1, ALB
17celecoxib44 59 28 49 11 2415.8GAST, HRH2, PTGS1, PTGS2, ALB
18indomethacin44 59 28 1113.8SCT, AKR1A1, ALB, CDKN3, CYP2C19, PTGS1
19ethanol44 49 11 2413.8CTSD, SCT, AKR1A1, MUC5AC, CYP2C19, HRH2
20lactate4410.8IL8, PTGS1, ALB, CTSD, AKR1A1, HRH2
21bicarbonate4410.8SCT, ALB, GAST, HRH2, AKR1A1
22esomeprazole44 49 1112.7ATP4A, GAST, CYP2C19
23lumiracoxib44 28 1112.7PTGS2, PTGS1, CYP2C19
24aspartate4410.7AKR1A1, HDC, CTSD, SCT, CD14, ALB
25lafutidine4410.7GAST, SCT, HRH2
26serine4410.7AKR1A1, MUC5AC, PTGS1, SCT, S100A8, CDKN3
27rantes4410.7CD14, CXCL1, HDC, SCT, S100A8
28triptolide4410.7IL8, PTGS1, PTGS2, CD14
29oxygen44 2411.7HRH2, IL8, S100A8, CTSD, CYP2C19, PTGS1
30histamine44 28 2412.7SCT, GAST, AKR1A1, HDC, MUC5AC, CD14
31retinoic acid44 2411.7CXCL1, CTSD, S100A8, MUC5AC, HDC, CD14
32nitric oxide44 11 2412.7MUC5AC, IL8, PTGS2, CXCL1, S100A8, CTSD
33cyclosporin a44 28 5912.7CTSD, SCT, CDKN3, IL8, CXCL1, CYP2C19
34tolmetin44 1111.7ALB, PTGS1, PTGS2
35cysteine4410.7IL8, CXCL1, CD14, MUC5AC, AKR1A1, ALB
36sulfasalazine44 28 49 1113.7PTGS2, PTGS1, IL8, CXCL1
37alanine4410.7CTSD, GAST, AKR1A1, S100A8, PTGS1, HDC
38bismuth44 2411.7GAST, HRH2, ALB
39glutamate4410.6SCT, GAST, HDC, AKR1A1
40vegf4410.6PTGS2, PTGS1, IL8, CTSD, CXCL1, CD14
41creatinine4410.6ALB, HRH2, CD14, S100A8, CTSD, GAST
42fosphenytoin44 1111.6CYP2C19, CDKN3, ALB
43valdecoxib44 28 11 2413.6PTGS2, PTGS1, CYP2C19
44etoricoxib44 28 1112.5CYP2C19, PTGS1, PTGS2
45adenylate4410.5CDKN3, SCT, HRH2, CXCL1, CTSD, GAST
46diflunisal44 1111.5PTGS1, PTGS2, ALB
47suprofen44 1111.4ALB, PTGS1, PTGS2
48herbimycin a44 5911.4CDKN3, CD14, IL8, PTGS2, PTGS1
49calcium44 49 11 2413.2CTSD, SCT, S100A8, ALB, MUC5AC, CDKN3
50pd 98,0594410.1CXCL1, CD14, IL8, MUC5AC, PTGS2, SCT

GO Terms for genes affiliated with Peptic Ulcer

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16Gene Ontology
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Cellular components related to Peptic Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.3CTSD, DEFA5, CD14, CXCL1, IL8, ALB
2extracellular regionGO:00557610.0ALB, S100A8, SCT, CTSD, GAST, DEFA5

Biological processes related to Peptic Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclooxygenase pathwayGO:01937110.4PTGS2, PTGS1
2inflammatory responseGO:00695410.3PTGS2, IL8, CXCL1, CD14, S100A8
3arachidonic acid metabolic processGO:01936910.1CYP2C19, PTGS1, PTGS2

Molecular functions related to Peptic Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prostaglandin-endoperoxide synthase activityGO:00466610.4PTGS2, PTGS1

Products for genes affiliated with Peptic Ulcer

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  • Antibodies

Sources for Peptic Ulcer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet