Peptic Ulcer malady

MedlinePlus: A peptic ulcer is a sore in the lining of your stomach or your duodenum, the first part of your small intestine. a burning stomach pain is the most common symptom. the pain may come and go for a few days or weeks may bother you more when your stomach is empty usually goes away after you eat peptic ulcers happen when the acids that help you digest food damage the walls of the stomach or duodenum. the most common cause is infection with a bacterium called helicobacter pylori. another cause is the long-term use of nonsteroidal anti-inflammatory medicines (nsaids) such as aspirin and ibuprofen. stress and spicy foods do not cause ulcers, but can make them worse. peptic ulcers will get worse if not treated. treatment may include medicines to block stomach acids or antibiotics to kill ulcer-causing bacteria. not smoking and avoiding alcohol can help. surgery may help for ulcers that don't heal. nih: national institute of diabetes and digestive and kidney diseases²³

MalaCards: Peptic Ulcer, also known as acute peptic ulcer without hemorrhage and without perforation (disorder), is related to gastritis and duodenal ulcer. An important gene associated with Peptic Ulcer is ATP4A (ATPase, H+/K+ exchanging, alpha polypeptide), and among its related pathways are Bacterial infections in CF airways and RAR-Gamma-RXR-Alpha Degradation. The drugs clidinium bromide and propantheline and the compounds serine and glucose have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and kidney, and related mouse phenotypes are cardiovascular system and liver/biliary system.

Wikipedia: A peptic ulcer, also known as PUD or peptic ulcer disease, is the most common ulcer of an area of the...⁴⁴ more...

Aliases & Descriptions:

peptic ulcer 6 8 32 23 43 acute peptic ulcer without hemorrhage and without perforation (disorder) 6 acute peptic ulcer without hemorrhage and without perforation 6

acute peptic ulcer with hemorrhage and perforation 6 acute peptic ulcer with hemorrhage 6 acute peptic ulcer (disorder) 43

Diseases related to peptic ulcer by text searches and GeneDecks gene sharing:

(show top 50)    (show all 951)

id	Related Disease	Score	Top Affiliating Genes
1	gastritis	36.2	SCT, S100A8, IL1RN, IL8, GHRL, DEFB4A
2	duodenal ulcer	31.9	SCT, S100A8, GRP, IL1RN, HRH2, GAST
3	dyspepsia	31.4	S100A8, ATP4A, ATP12A, CD79A, CD14, MLN
4	gastric adenocarcinoma	30.9	NAT1, S100A8, GRP, IL1RN, CCKBR, HRH2
5	stomach disease	30.8	HRH2, PTGS2, PTGS1
6	gastric outlet obstruction	30.7	ATP4A, ATP12A, MLN, GAST
7	barrett's esophagus	30.3	MUC5AC, S100A8, PTGS2, PTGS1, TGFA, TFF1
8	atrophic gastritis	30.3	SCT, S100A8, XDH, MEN1, IL1RN, AKR1A1
9	zollinger-ellison syndrome	30.0	SCT, MLN, MEN1, GRP, IL6, IL8
10	hepatitis	29.9	XDH, GZMB, GSR, F2, ALB, TXN
11	gastrinoma	29.8	GCG, SCT, ATP4A, ATP12A, MEN1, GRP
12	liver cirrhosis	29.7	GCG, SCT, MUC5AC, XDH, CD14, F2
13	multiple endocrine neoplasia	28.8	GCG, SCT, FGF2, MEN1, GHRL, SST
14	gastroesophageal reflux disease	27.7	GCG, SCT, S100A8, ATP4A, ATP12A, MLN
15	insulinoma	27.3	GCG, SCT, CDKN3, GSR, MEN1, GRP
16	gastric ulcer	27.1	MUC5AC, S100A8, GSR, FGF2, IL1B, IL1RN
17	was-related disorders	27.1	XDH, MEN1, IL6, IL8, APOA1, HRH2
18	gastroduodenitis	25.6	GCG, SCT, MUC5AC, S100A8, XDH, CD14
19	duodenitis	25.4	GCG, SCT, UGT1A6, MUC5AC, S100A8, XDH
20	hyperparathyroidism	25.1	SCT, FGF2, MEN1, IL10, IL2, IL4
21	gastric cancer	21.4	REG4, GCG, NAT1, UGT1A6, MUC5AC, MUC5B
22	adenoma	18.5	REG4, GCG, NAT1, SCT, UGT1A6, MUC5AC
23	adenocarcinoma	17.4	REG4, GCG, NAT1, SCT, UGT1A6, MUC5AC
24	duodenal gastrinoma	13.9	SCT, MEN1, CCKBR, GAST
25	acute fatty liver of pregnancy	13.9	CDKN3, F2, ALB
26	peutz-jeghers syndrome	13.9	MUC5AC, TFF1, GAST
27	pseudomyxoma peritonei	13.9	REG4, MUC5AC, MUC5B, F2
28	gastric antral vascular ectasia	13.9	ATP4A, ATP12A, SST
29	vericose veins	13.9	F2, ALB, SST
30	esophageal varix	13.8	F2, ALB, SST
31	portal hypertension	13.8	F2, ALB, SST, CPOX
32	cystic teratoma	13.8	MUC5AC, CDKN3, CALB2, PTGS2
33	duodenum cancer	13.8	MEN1, SST, GAST
34	crigler-najjar syndrome	13.8	UGT1A6, F2, ALB, CYP2C19, ABO
35	vipoma	13.8	SCT, MEN1, SST, NTS, GAST
36	choledochal cyst	13.8	SCT, PTGS2, SST
37	angiodysplasia	13.8	SCT, SST, ACVRL1
38	acute porphyria	13.8	UROD, MLN, NTS, CPOX
39	megaloblastic anemia	13.8	DNAH8, PGA3, PGA4, GAST
40	somatostatinoma	13.8	GCG, MEN1, SST, GAST
41	pancreatic islet cell tumors	13.8	MEN1, SST, NTS, GAST
42	morphine dependence	13.8	CCKBR, CCK, PTGS2, PTGS1
43	galactosemia	13.8	IL18, F2, ALB, CYP2C19, CPOX
44	thyroid medullary carcinoma	13.8	GZMB, GRP, SST, CTSD, HDC
45	endocervicitis	13.7	MUC5AC, IL8, CALB2, TFF1, DEFA5
46	wermer syndrome	13.7	GCG, MEN1, SST, GAST
47	fournier gangrene	13.7	IGHE, F2, ALB
48	carcinoid syndrome	13.7	MLN, MEN1, SST, NTS, GAST
49	neuroendocrine carcinoma	13.7	GCG, MEN1, GRP, SST, HDC, GAST
50	drug-induced hepatitis	13.7	NAT1, UGT1A6, ALB, CAT, CYP2C19

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 clidinium, clidinium bromide, glycine, glycopyrrolate, hyoscyamine, hyoscyamine hydrobromide, hyoscyamine sulfate, propantheline, propantheline bromide

MalaCards organs/tissues related to peptic ulcer:

²²

MGI Mouse Phenotypes related to peptic ulcer:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system phenotype	MP:0005385	INF	PPARG, CTTN, PTGS1, PTGS2, TNF, CRP
2	liver/biliary system phenotype	MP:0005370	INF	CBS, NFE2L2, ABCB1, , SOD1, IFNG
3	homeostasis/metabolism phenotype	MP:0005376	INF	GCG, FGF2, MEN1, GRHPR, IL18, IL1RN
4	renal/urinary system phenotype	MP:0005367	10.2	NFE2L2, PTGS1, AKR1A1, CBS, CCKBR, GRHPR
5	endocrine/exocrine gland phenotype	MP:0005379	9.4	CACNA1E, IFNG, IL2, MEN1, XDH
6	no phenotypic analysis	MP:0003012	9.2	POMC, PPARG, NTS, CTTN, SST, PTGS2
7	skeleton phenotype	MP:0005390	8.9	TGFA, PPARG, PTGS2, AKR1A1, IL6, FGF2
8	integument phenotype	MP:0010771	8.4	PTGS1, EGF, TGFA, POMC, HDC, CBS
9	adipose tissue phenotype	MP:0005375	7.9	NTS, PPARG, TGFA, POMC, HDC, PTGS2
10	reproductive system phenotype	MP:0005389	7.7	CBS, AKR1A1, TNF, PTGS2, PTGS1, CTTN
11	behavior/neurological phenotype	MP:0005386	6.9	GHRL, PTGS1, SST, CTSD, NTS, PPARG
12	tumorigenesis	MP:0002006	6.6	TNF, PTGS2, PTGS1, PPARG, NFE2L2, TFF1
13	vision/eye phenotype	MP:0005391	5.9	TNF, PTGS2, CTSD, PPARG, EGF, TGFA
14	hematopoietic system phenotype	MP:0005397	INF	HDC, , NFE2L2, HLA-DQA1, AKR1A1, IGHE
15	nervous system phenotype	MP:0003631	INF	HRH2, CTSD, NTS, NFE2L2, , POMC
16	mortality/aging	MP:0010768	INF	CBS, CAT, AKR1A1, TXN, CTSD, CTTN
17	growth/size phenotype	MP:0005378	INF	SST, NTS, NFE2L2, EGF, , TGFA
18	digestive/alimentary phenotype	MP:0005381	INF	GHRL, PTGS1, SST, CTSD, NFE2L2, EGF
19	immune system phenotype	MP:0005387	INF	XDH, IFNG, F2, CBS, AKR1A1, HLA-DQA1
20	respiratory system phenotype	MP:0005388	INF	, CBS, IL12B, CD14
21	cellular phenotype	MP:0005384	INF	PTGS2, TNF, TXN, AKR1A1, CAT, CBS
22	normal phenotype	MP:0002873	INF	ALB, CACNA1E, CALB2, GHRL, SST, NFE2L2
23	muscle phenotype	MP:0005369	INF	TNF, PTGS2, PTGS1, PPARG, , TGFA

Articles related to peptic ulcer:

(show top 50)    (show all 179)

id	Title	Authors	Year	Affiliating Genes
1	Correlation of CYP2C19 genetic polymorphisms with hel icobacter pylori eradication in patients with cirrhosis and peptic ulcer. (20457439)	Lay C.S.... Lin J.R.	2010	CYP2C19
2	Intravenous pantoprazole as an adjuvant therapy following successful endoscopic treatment for peptic ulcer bleeding. (19373423)	Wang J.... He X.	2009	SST
3	Serum levels of high-sensitivity C-reactive protein ( hs-CRP)in Helicobacter pylori-infected peptic ulcer patients and its associatio n with bacterial CagA virulence factor. (19160050)	Jafarzadeh A.... Nemati M.	2009	CRP
4	Diverse characteristics of the CagA gene of Helicobac ter pylori strains collected from patients from southern vietnam with gastric c ancer and peptic ulcer. (19846630)	Truong B.X.... Azuma T.	2009	S100A8
5	Blood concentration of pantoprazole sodium is significantly high in hepatogenic peptic ulcer patients, especially those with a poor CYP2C19 metabolism. (19236548)	Shao J.G.... Sun Y.Y.	2009	CYP2C19
6	Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T cell responses. (18467372)	Robinson K.... Atherton J.C.	2008	IL8
7	Hospitalization for peptic ulcer and bleeding in users of selective COX-2 inhibitors and nonselective NSAIDs with special reference to celecoxib. (18711705)	Patterson M.K.... Walker A.M.	2008	PTGS2
8	Peculiarities of genotype distribution of interleukins (IL-1 and IL-10) in patients with peptic ulcer disease and their associations with persistence of Mycoplasma hyorhinis and Helicobacter pylori genotypes (19334424)	Abuzarova E.R.... Abdulkhakov R.A.	2008	IL1B, IL10, IL1RN
9	Alterations in antral cytokine gene expression in peptic ulcer patients during ulcer healing and after Helicobacter pylori eradication. (18028289)	Goll R.... Florholmen J.	2008	TNF, IL6, IL1B
10	Helicobacter pylori cag pathogenicity island genes: clinical relevance for peptic ulcer disease development in Brazil. (17172510)	Mattar R.... Carrilho F.J.	2007	S100A8
11	Dominant cagA/vacA genotypes and coinfection frequency of H. pylori in peptic ulcer or chronic gastritis patients in Zhejiang Province and correlations among different genotypes, coinfection and severity of the diseases. (15788126)	Chen X.J.... Shen Y.F.	2005	S100A8
12	Lewis blood genotypes of peptic ulcer and gastric cancer patients in Taiwan. (16097066)	Yei C.J.... Liu T.C.	2005	FUT3
13	Somatostatin inhibits gastric acid secretion more effectively than pantoprazole in patients with peptic ulcer bleeding: a prospective, randomized, placebo-controlled trial. (16036503)	Avgerinos A.... Raptis S.A.	2005	SST
14	Lack of association of IL-12 p40 gene polymorphism with peptic ulcer disease. (15620465)	Garcia-Gonzalez M.A.... Pena S.	2005	IL12B
15	Serum positive cagA in patients with non-ulcer dyspepsia and peptic ulcer disease from two centers in different regions of Turkey. (12679943)	Serin E.... BoyacioA9lu S.	2003	S100A8
16	Identification of cagA tyrosine phosphorylation DNA motifs in Helicobacter pylori isolates from peptic ulcer patients by novel PCR-restriction fragment length polymorphism and real-time fluorescence PCR assays. (12843050)	Owen R.J.... Rijpkema S.	2003	S100A8
17	Successful eradication of Helicobacter pylori prevents relapse of peptic ulcer disease. (11966543)	Tomita T.... Shimoyama T.	2002	HRH2
18	Consensus and variable region PCR analysis of Helicobacter pylori 3' region of cagA gene in isolates from individuals with or without peptic ulcer. (11158115)	Rota C.A.... Nardi N.B.	2001	S100A8
19	The importance of vacA, cagA, and iceA genotypes of Helicobacter pylori infection in peptic ulcer disease and gastroesophageal reflux disease. (11569682)	Arents N.L.... Van Doorn L.J.	2001	S100A8
20	Overexpression of co-stimulatory molecules in peripheral mononuclear cells of Helicobacter pylori-positive peptic ulcer patients: possible difference in host responsiveness compared with non-ulcer patients. (11204803)	Ohara T.... Kaneda K.	2001	ITGA4
21	Helicobacter pylori and immunogenetic factors of the host: relevance of the HLADQA1 *0102 and *0301 alleles in peptic ulcer (11261221)	Santolaria S.... Lanas A.	2001	HLA-DQA1
22	Genetic analysis and clinical evaluation of vacuolating cytotoxin gene A and cytotoxin-associated gene A in Taiwanese Helicobacter pylori isolates from peptic ulcer patients. (10716078)	Lin C.W.... Cheng K.S.	2000	S100A8
23	The status of the cagA gene does not predict Helicobacter pylori-associated peptic ulcer disease in Singapore. (10885501)	Hua J.... Ho B.	2000	S100A8
24	Seroprevalence of eight Helicobacter pylori antigens among 182 patients with peptic ulcer, MALT gastric lymphoma or non-ulcer dyspepsia. Higher rate of seroreactivity against CagA and 35-kDa antigens in patients with peptic ulcer originating from Europe and Africa. (10445790)	Lamarque D.... Delchier J.C.	1999	S100A8
25	Lack of correlation between vacuolating cytotoxin activity, cagA gene in Helicobacter pylori, and peptic ulcer disease in children. (9832269)	Loeb M.... Sherman P.	1998	S100A8
26	Immunocytochemical evaluation of gastric mucosal cathepsin D in peptic ulcer. (9798410)	DA8ugosz A.... Chosia M.	1998	CTSD
27	Helicobacter pylori cytotoxic genotype is associated with peptic ulcer and influences serology. (9468248)	Navaglia F.... Plebani M.	1998	S100A8
28	Omeprazole. A review of its use in Helicobacter pylori infection, gastro-oesophageal reflux disease and peptic ulcers induced by nonsteroidal anti-inflammatory drugs. (9777317)	Langtry H.D.... Wilde M.I.	1998	HRH2
29	The trophic and compensatory effects of gastrin in patients with duodenal peptic ulcer (9446285)	GolofeevskiA- V.I.u.	1997	GAST
30	Serum CagA antibodies in asymptomatic subjects and patients with peptic ulcer: lack of correlation of IgG antibody in patients with peptic ulcer or asymptomatic Helicobacter pylori gastritis. (8943750)	Graham D.Y.... Crabtree J.E.	1996	S100A8
31	Serum concentration of prolactin, gastrin and glycocholic acid in patient with peptic ulcer treated with ranitidine (11785198)	PrzybyA8owski J.... MaA9lany P.	1995	GAST
32	The hormonal characteristics of the pathogenesis of gastric peptic ulcer and duodenal peptic ulcer (8779096)	Loginov A.S.... Zvenigorodskaia L.A.	1995	SST, GRP, GAST
33	The prevalence of Helicobacter pylori in peptic ulcer disease. (8547530)	Kuipers E.J.... Festen H.P.	1995	S100A8
34	Treatment of peptic ulcers from now to the millennium. (7949462)	Pounder R.E.	1994	HRH2
35	Specific IgE in the gastric and duodenal mucosa. An epiphenomenon or pathogenetic mechanism of some forms of 'peptic' ulcer? (8204699)	De Lazzari F.... Naccarato R.	1994	IGHE
36	Long-term omeprazole therapy in peptic ulcer disease: gastrin, endocrine cell growth, and gastritis. (8482449)	Lamberts R.... Solcia E.	1993	GAST
37	Effectiveness of lecedil (famotidine) in the therapy of patients with peptic ulcer (8145499)	Grebenev A.L.... Trukhmanov A.S.	1993	HRH2
38	The effect of microwave resonance therapy and hypnot herapy on the links in the pathogenesis of peptic ulcer (1455836)	Kan E.B.... Nikula T.D.	1992	POMC
39	Renal effects of peptic ulcer therapy. (1524700)	Burgess E.... Muruve D.	1992	HRH2
40	Allopurinol and dimethyl sulfoxide improve treatment outcomes in smokers with peptic ulcer disease. (1593216)	Salim A.S.	1992	XDH
41	Natural history of gastritis and its relationship to peptic ulcer disease. (1397747)	Sipponen P.	1992	GAST
42	Detection and characterization of circulating immune complexes in peptic ulcer. (1490153)	Begum S.... Habibullah C.M.	1992	CD79A
43	A case of multiple endocrine neoplasia: hyperparathyroidism, insulinoma, GRF-oma, hypercalcitoninaemia and intractable peptic ulceration. (1356665)	Price D.E.... Howlett T.A.	1992	GAST
44	The effect of food intake on the content of proteolytic enzymes and gastrin in the blood of patients with peptic ulcer and chronic atrophic gastritis (1792741)	Eremina E.I.u.	1991	GAST
45	Roxatidine acetate. A review of its pharmacodynamic a nd pharmacokinetic properties, and its therapeutic potential in peptic ulcer di sease and related disorders. (1717223)	Murdoch D.... McTavish D.	1991	HRH2
46	Gastric juice immunoreactive epidermal growth factor levels in patients with peptic ulcer disease. (2327382)	CalabrA^ A.... Surrenti C.	1990	EGF
47	A comparative study on gastric emptying and secretory status in the early postoperative period after truncal vagotomy with two pylor oplasty variants performed for peptic ulcer disease. II. Heineke-Mikulicz pylor oplasty and comparison with the cassimally routine. (2131652)	Lukasiewicz S.... Jonderko K.	1990	GAST
48	Gastrin tissue levels in patients with peptic ulcer: a different methodological approach (2079883)	GermanA B.... Naccarato R.	1990	GAST
49	Role of growth factors in gastroduodenal protection a nd healing of peptic ulcers. (1970337)	Konturek S.J.	1990	EGF
50	Histology of gastric biopsies from peptic ulcer patients before and after short-term treatment with omeprazole or H2-receptor antagonists. (1978433)	Helander H.F.... Eriksson S.	1990	HRH2

Genes related to peptic ulcer according to GeneCards:

(show top 50)    (show all 86)

id	Symbol	Description	Score	GeneCards Section Context
1	ATP4A	ATPase, H+/K+ exchanging, alpha polypeptide	11.1	Summaries
2	S100A8	S100 calcium binding protein A8	11.0	Publications
3	HRH2	histamine receptor H2	11.0	Publications
4	GAST	gastrin	11.0	Publications
5	POMP	proteasome maturation protein	11.0
6	SCT	secretin	11.0	Publications
7	HDC	histidine decarboxylase	11.0
8	CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	11.0
9	MUC5AC	mucin 5AC, oligomeric mucus/gel-forming	11.0	Publications
10	CTSD	cathepsin D	11.0	Publications
11	CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	11.0	Publications
12	PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
13	AKR1A1	aldo-keto reductase family 1, member A1 (aldehyde reductase)	11.0
14	CDKN3	cyclin-dependent kinase inhibitor 3	11.0	Publications
15	IL8	interleukin 8	11.0	Publications
16	CD14	CD14 molecule	11.0
17	F2	coagulation factor II (thrombin)	11.0	Publications
18	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
19	ALB	albumin	11.0	Publications
20	PGA4	pepsinogen 4, group I (pepsinogen A)	11.0
21	DDX53	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	11.0
22	DEFA5	defensin, alpha 5, Paneth cell-specific	11.0	Publications
23	REG4	regenerating islet-derived family, member 4	11.0	Functions
24	PGA3	pepsinogen 3, group I (pepsinogen A)	11.0
25	OCM2	oncomodulin 2	11.0
26	PRSS27	protease, serine 27	11.0
27	OCM	oncomodulin	11.0
28	GRHPR	glyoxylate reductase/hydroxypyruvate reductase	11.0
29	UROD	uroporphyrinogen decarboxylase	11.0	Publications
30	TREM1	triggering receptor expressed on myeloid cells 1	11.0	Publications
31	DEFB1	defensin, beta 1	11.0	Publications
32	CPOX	coproporphyrinogen oxidase	11.0	Publications
33	UGT1A6	UDP glucuronosyltransferase 1 family, polypeptide A6	11.0	Publications
34	FUT3	fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)	11.0	Publications
35	PGC	progastricsin (pepsinogen C)	11.0
36	PIGG	phosphatidylinositol glycan anchor biosynthesis, class G	11.0
37	MUC5B	mucin 5B, oligomeric mucus/gel-forming	11.0
38	MLN	motilin	11.0
39	MEN1	multiple endocrine neoplasia I	11.0
40	TFF1	trefoil factor 1	11.0	Publications
41	DEFB4A	defensin, beta 4A	11.0	Publications
42	SST	somatostatin	11.0	Publications
43	CCKBR	cholecystokinin B receptor	11.0	Publications
44	ATP12A	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	11.0
45	CALB2	calbindin 2	11.0	Publications
46	MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	11.0	Publications
47	NFE2L2	nuclear factor (erythroid-derived 2)-like 2	11.0	Publications
48	IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	11.0	Publications
49	GRP	gastrin-releasing peptide	11.0	Publications
50	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	11.0	Publications

Pathways related to peptic ulcer according to GeneDecks:

(show top 50)    (show all 77)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways41	10.7	DEFB4A
2	RAR-Gamma-RXR-Alpha Degradation36	10.4	IL2, CXCL1
3	Graft-versus-host disease20	10.3	HLA-DQA1, IL2
4	G alpha (q) signalling events38	9.9	GAST, NTS, GHRL, CCK, CCKBR, GRP
5	NFAT Signaling and Lymphocyte Interactions36	9.8	CACNA1E, IL4, IL2, IL12B
6	Immune response_Bacterial infections in normal airways41	9.7	DEFB4A, IFNG, IL1B, CD14
7	PGC1Alpha Pathway36	9.4	IL8, IL4, IL2, IL1B, IL18, IL12B
8	Regulation of eIF4 and p70S6K36	9.2	EGF, IL6, IL4, IL2, IL18, IL12B
9	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.1	IFNG, IL6, IL4, IL1B, IL12B, GZMB
10	Immune System38	9.1	DEFA5, DEFB4A, DEFB1, CTSD, IFNG, IL18
11	NOD-like receptor signaling pathway20	9.1	IL18, IL1B, IL6, IL8, TNF, CXCL1
12	Endothelin-1 Signaling Pathway36	9.0	CXCL1, IL6, IL4, IL2, IL1B, IL18
13	Pertussis20	9.0	TNF, IL8, IL6, IL1B, IL12B, IL10
14	Immune response_MIF in innate immunity response41	9.0	MIF, IL1B, IL6, IL8, IFNG, TNF
15	Immune response MIF in innate immunity response10	9.0	PTGS2, CD14, MIF, IL1B, IL6, IL8
16	Doxorubicin Pathway, Pharmacokinetics34	8.9	SOD1, ABCB1, AKR1A1, CAT, XDH
17	Intestinal immune network for IgA production20	8.9	HLA-DQA1, IL6, IL4, IL2, IL10, ITGA4
18	Immune response_MIF-mediated glucocorticoid regulation41	8.8	IL2, IL6, IL8, IFNG, TNF, PTGS2
19	Immune response MIF-mediated glucocorticoid regulation10	8.8	PTGS2, MIF, IL2, IL6, IL8, IFNG
20	Rheumatoid arthritis20	8.7	CXCL1, TNF, HLA-DQA1, IFNG, IL8, IL6
21	Amoebiasis20	8.7	CXCL1, TNF, IFNG, IL8, IL6, IL1B
22	Rho Family GTPases36	8.7	IL4, IL8, TGFA, CXCL1, IL2, IL1B
23	Type I diabetes mellitus20	8.7	TNF, HLA-DQA1, IFNG, IL2, IL1B, IL12B
24	Malaria20	8.6	TNF, IFNG, IL8, IL6, IL1B, IL18
25	Chagas disease (American trypanosomiasis)20	8.6	TNF, IFNG, IL6, IL1B, IL12B, IL10
26	SOCS Pathway36	8.6	IL4, IL6, IL8, EGF, IL2, IL1B
27	Leishmaniasis20	8.6	PTGS2, TNF, HLA-DQA1, IFNG, IL4, IL1B
28	Th1 Differentiation37	8.5	TNF, IFNG, IL2, IL18, IL12B, IL10
29	Allograft rejection20	8.4	TNF, HLA-DQA1, IFNG, IL4, IL2, IL12B
30	THC Differentiation Pathway36	8.4	TNF, HLA-DQA1, IFNG, IL4, IL2, IL18
31	PEDF Induced Signaling36	8.4	CXCL1, TNF, IL8, IL6, IL4, IL2
32	Tuberculosis20	8.4	CTSD, TNF, HLA-DQA1, IFNG, IL6, IL1B
33	IL-6 Pathway36	8.3	CXCL1, TNF, IL8, IL6, IL4, IL2
34	TGF-Beta Pathway36	8.3	TGFA, EGF, IL8, IL6, IL4, IL2
35	MIF Mediated Glucocorticoid Regulation36	8.2	IL6, IL8, TNF, PTGS2, CXCL1, IL4
36	MIF Regulation of Innate Immune Cells36	8.2	IL6, IL8, TNF, PTGS2, CXCL1, IL4
37	ERK Signaling36	8.2	IL6, CACNA1E, EGF, TGFA, CXCL1, IL4
38	all-trans-Retinoic Acid Signaling in Brain36	8.2	IL8, CACNA1E, TNF, PTGS2, CXCL1, IL6
39	Cytokine Network36	7.9	IL10, TNF, IFNG, IL8, IL6, IL4
40	PAK Pathway36	7.9	IL6, IL8, TNF, TGFA, CXCL1, IL4
41	JAK-STAT Pathway36	7.8	IL2, IL1B, IL18, IL12B, IL10, IL4
42	Cytokine-cytokine receptor interaction20	7.6	IL8, IFNG, TNF, EGF, CXCL1, IL6
43	MAPK Family Pathway36	7.6	IL6, IL8, TNF, EGF, TGFA, IL4
44	Antioxidant Action of Vitamin-C36	INF	CXCL1, TGFA, FGF2, IL10, IL12B, IL18
45	Molecular Mechanisms of Cancer36	INF	CXCL1, TGFA, , EGF, IL6, IL2
46	p38 Signaling36	INF	IL8, TNF, EGF, , TGFA, CXCL1
47	Tec Kinases Signaling36	INF	TGFA, , EGF, IL8, IL6, IL4
48	Akt Signaling36	INF	CXCL1, , TNF, IL6, IL4, IL2
49	African trypanosomiasis20	INF	TNF, IFNG, , IL6, IL1B, IL18
50	STAT3 Pathway36	INF	CXCL1, , TNF, IL8, IL6, IL4

Compounds related to peptic ulcer according to GeneDecks:

(show top 50)    (show all 518)

id	Compound	Score	Top Affiliating Genes
1	serine32	INF	TXN, GHRL, AKR1A1, HRH2, CBS, F2
2	glucose32	10.0	NFE2L2, NTS, MIF, GZMB, FUT3, SCT
3	oxyntomodulin32 42	10.7	GAST, TGFA, NTS, SST, GHRL, CCK
4	ascorbic acid32 18	10.7	CTSD, TXN, IGHE, NAT1, GAST, POMC
5	endotoxin32	9.5	CXCL1, DEFB4A, CRP, GHRL, HRH2, F5
6	ranitidine32 9 18 9	12.5	GAST, ABCB1, CYP2C19, AKR1A1, HRH2, CCK
7	octreotide32 42 9 9	12.4	MLN, SCT, GCG, GRP, CCKBR, CCK
8	acetaminophen32 34 9 18 9	13.3	GAST, ABCB1, PTGS1, GHRL, HRH2, F2
9	omeprazole32 42 34 9 18 9	14.2	CCK, CCKBR, MLN, ATP4A, S100A8, SCT
10	corticosterone32 18	10.0	IL1RN, IL1B, GRP, FGF2, MIF, GCG
11	dtpa32	8.9	CAT, ALB, CCK, CCKBR, GRP, XDH
12	calcitriol32 42 9 18 9	12.9	CD14, S100A8, FGF2, GRP, IL2, GAST
13	heparin32 9 18 9	11.8	GAST, GCG, CD79A, POMC, CXCL1, DEFB4A
14	5-hydroxytryptamine32	8.7	GHRL, AKR1A1, HRH2, CALB2, F2, CCK
15	sulfasalazine32 9 9	10.6	CXCL1, CRP, PPARG, PTGS1, TNF, IL1RN
16	calcium32 9 18 9	11.4	GAST, HDC, CPOX, OCM2, CXCL1, DEFB4A
17	cysteine32	8.4	CD14, CD79A, FUT3, XDH, S100A8, MUC5AC
18	bucillamine32	8.2	CRP, CAT, IFNG, IL6, IL2, IL1B
19	glutamate32	8.2	HDC, CPOX, OCM2, TGFA, NFE2L2, NTS
20	paraffin32	8.0	CTSD, PTGS1, HLA-DQA1, GHRL, CALB2, IL4
21	15-deoxy-delta-12,14-prostaglandin j232	7.7	TNF, TXN, IFNG, IL8, IL6, IL4
22	adenylate32	7.6	TGFA, EGF, NTS, CTSD, SST, TXN
23	histamine32 18	8.6	MUC5AC, SCT, GCG, ALB, IGHE, CCK
24	pentoxifylline32 9 9	9.5	IL1B, IL18, IL12B, IL10, ITGA4, CD14
25	norepinephrine32 9 18 9	10.5	IL18, GRP, MIF, CD14, CD79A, SCT
26	ly29400232	7.4	IL4, IL1B, IL18, IL10, FGF2, GZMB
27	nitric oxide32 9 18 9	10.2	IFNG, NAT1, MUC5AC, S100A8, CCKBR, IL8
28	methotrexate32 34 42 9 9	11.1	GSR, CD79A, S100A8, MUC5AC, TGFA, ABCB1
29	pdtc32	7.1	XDH, IL18, SOD1, NFE2L2, PPARG, PTGS2
30	cyclosporin a32 42	8.0	CXCL1, DNAH8, TGFA, ABCB1, CTSD, CYP2C19
31	arginine32	6.5	POMC, SOD1, DNAH8, TFF1, ABO, NTS
32	thymidine32 18	7.5	CALB2, IFNG, CCKBR, IL6, IL4, IL2
33	prednisolone32 9 9	8.0	POMC, DNAH8, ABCB1, CRP, TNF, ALB
34	cycloheximide32	4.2	HDC, CPOX, POMC, CXCL1, TFF1, TGFA
35	estrogen32	INF	DEFB4A, GRP, MEN1, GSR, MIF, GZMB
36	dexamethasone32 42 34 9 9	INF	CPOX, POMC, CXCL1, DEFB4A, DEFB1, TFF1
37	genistein32 9 18 9	INF	PTGS1, PTGS2, TNF, IFNG, , IL8
38	creatinine32	INF	GHRL, AKR1A1, HRH2, F5, IGHE,
39	acetylcholine32 9 18 9	INF	GAST, POMC, DNAH8, TGFA, CRP, NTS
40	alanine32	INF	TGFA, GRP, FGF2, MIF, GZMB, MLN
41	testosterone32 9 18 9	INF	ABCB1, EGF, NTS, CTSD, SST, CYP2C19
42	aspartate32	INF	HDC, POMC, SCT, CD14, OCM2, DNAH8
43	thyroxine32 18	INF	IL10, FGF2, GSR, MLN, CD79A, SCT
44	pge232	INF	GAST, HDC, CPOX, CXCL1, TGFA, EGF
45	indomethacin32 9 9	INF	CPOX, POMC, SOD1, DNAH8, TFF1, TGFA
46	vegf32	INF	GAST, POMC, CXCL1, TFF1, , CRP
47	infliximab32 9 9	INF	, IL6, IL4, IL1RN, IL1B, IL18
48	tacrolimus32 34 9 9	INF	TNF, F5, IFNG, , IL4, IL2
49	h2o232	INF	NAT1, XDH, CD79A, HDC, CPOX, POMC
50	aspirin32 34 18	INF	, IL1RN, IL18, GRP, CD79A, UGT1A6

Cellular components related to peptic ulcer according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	Golgi lumen	GO:005796	10.2	MUC5AC, MUC5B, F2, DEFB1, DEFB4A, DEFA5
2	extracellular space	GO:005615	INF	PGC, IL8, IL6, IL4, IL2, IL1RN
3	secretory granule	GO:030141	INF	POMC, DEFA5, GHRL, , IL1B, GCG
4	extracellular region	GO:005576	INF	GAST, PGA4, POMC, REG4, CCK,

Biological processes related to peptic ulcer according to GeneDecks:

(show all 49)

id	Name	GO ID	Score	Top Affiliating Genes
1	digestion	GO:007586	10.5	PGC, PGA4, TFF1, SST, CCKBR, MUC5AC
2	chronic inflammatory response to antigenic stimulus	GO:002439	10.5	IL1RN, IL1B
3	positive regulation of granulocyte macrophage colony-stimulating factor production	GO:032725	10.3	IL1B, IL18, IL12B
4	response to organic nitrogen	GO:010243	10.2	PTGS1, PTGS2, IL1RN, IL1B
5	type 2 immune response	GO:042092	10.2	IL4, IL18, IL10
6	chemotaxis	GO:006935	10.2	CXCL1, DEFB4A, DEFB1, IL4, FGF2, S100A8
7	positive regulation of tissue remodeling	GO:034105	10.1	IL2, IL18, IL12B
8	positive regulation of tumor necrosis factor production	GO:032760	9.9	IFNG, IL18, IL12B, CD14
9	positive regulation of cell division	GO:051781	9.9	TGFA, CAT, IL1B, MEN1, FGF2
10	positive regulation of activated T cell proliferation	GO:042104	9.9	IL4, IL2, IL18, IL12B
11	cellular response to lipopolysaccharide	GO:071222	9.9	IFNG, IL8, IL12B, IL10, CD14
12	positive regulation of fever generation	GO:031622	9.9	PTGS2, TNF, IL1B
13	positive regulation of interleukin-17 production	GO:032740	9.8	IL2, IL18, IL12B
14	positive regulation of cytokine secretion	GO:050715	9.8	TNF, IL10, MIF, CD14
15	positive regulation of MHC class II biosynthetic process	GO:045348	9.7	IFNG, IL4, IL10
16	B cell differentiation	GO:030183	9.6	CD79A, ITGA4, IL10, IL4
17	positive regulation of isotype switching to IgG isotypes	GO:048304	9.6	IFNG, IL4, IL2
18	acute-phase response	GO:006953	9.6	CRP, F2, IL6, IL1RN
19	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.5	TNF, IFNG, IL1B
20	positive regulation of mitosis	GO:045840	9.5	TGFA, EGF, TNF, IL1B
21	MAPK cascade	GO:000165	9.4	TGFA, TNF, IL1B, IL18, MEN1
22	positive regulation of T cell proliferation	GO:042102	9.4	IL12B, IL1B, IL4, IL6, IFNG
23	negative regulation of growth of symbiont in host	GO:044130	9.4	TNF, IFNG, IL12B, IL10
24	cellular response to organic cyclic compound	GO:071407	9.4	PPARG, TNF, IL1B, IL18
25	negative regulation of lipid storage	GO:010888	9.3	CRP, TNF, IL6
26	positive regulation of nitric oxide biosynthetic process	GO:045429	9.3	PTGS2, TNF, IFNG, IL1B
27	positive regulation of interferon-gamma production	GO:032729	9.3	TNF, IL2, IL1B, IL18, IL12B
28	positive regulation of chemokine biosynthetic process	GO:045080	9.2	TNF, IFNG, IL4, IL1B
29	immune response	GO:006955	9.2	HLA-DQA1, DEFB1, DEFB4A, CXCL1, HRH2, IGHE
30	response to glucocorticoid stimulus	GO:051384	9.2	IL10, IL1B, IL1RN, IL6, TNF, PTGS2
31	cell-cell signaling	GO:007267	9.1	POMC, SST, TXN, IL2, IL1B, IL18
32	regulation of insulin secretion	GO:050796	9.0	TNF, CACNA1E, IFNG, IL1B, GCG
33	humoral immune response	GO:006959	8.9	IL6, IFNG, TREM1, TNF
34	positive regulation of ERK1 and ERK2 cascade	GO:070374	8.9	TNF, IL1B, FGF2, MIF, GCG
35	negative regulation of apoptotic process	GO:043066	8.8	TNF, GHRL, CAT, ALB, IL6, IL4
36	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	8.7	PPARG, TNF, IL6, IL4, IL1B, IL10
37	activation of MAPK activity	GO:000187	8.6	SOD1, TGFA, TNF, GHRL, IL1B, FGF2
38	inflammatory response	GO:006954	8.5	S100A8, CXCL1, CD14, MIF, IL10, IL18
39	anti-apoptosis	GO:006916	7.9	SOD1, TGFA, TNF, GHRL, IL2, IL1B
40	response to drug	GO:042493	7.1	IL1RN, IL4, IFNG, TNF, PTGS2, SST
41	platelet activation	GO:030168	INF	SOD1, EGF, ALB, F2, F5,
42	negative regulation of cytokine secretion involved in immune response	GO:002740	INF	IL10, , TNF
43	small molecule metabolic process	GO:044281	INF	CAT, TXN, PTGS2, PTGS1, CYP2C19, ABCB1
44	negative regulation of cell proliferation	GO:008285	INF	CXCL1, , SST, PTGS2, TNF, IL8
45	G-protein coupled receptor signaling pathway	GO:007186	INF	GAST, CXCL1, DEFB4A, DEFB1, SST, GHRL
46	signal transduction	GO:007165	INF	PPARG, EGF, , CXCL1, POMC, GAST
47	platelet degranulation	GO:002576	INF	SOD1, EGF, ALB, F5,
48	regulation of blood pressure	GO:008217	INF	POMC, SOD1, , PPARG, PTGS1, PTGS2
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	TNF, PPARG, NFE2L2, , POMC, IFNG

Molecular functions related to peptic ulcer according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:005179	9.6	GAST, POMC, SST, CCK, MLN, SCT
2	receptor binding	GO:005102	9.2	POMC, CXCL1, CAT, F2, GRP, MIF
3	protein homodimerization activity	GO:042803	8.1	CPOX, SOD1, CRP, PTGS2, CAT, CBS
4	growth factor activity	GO:008083	8.1	FGF2, CXCL1, TFF1, TGFA, EGF, F2
5	cytokine activity	GO:005125	7.3	IL4, IL6, IFNG, TNF, IL2, IL1B
6	enzyme binding	GO:019899	INF	CYP2C19, PTGS2, CAT, CBS, , UGT1A6