MCID: PPT003
MIFTS: 61

Peptic Ulcer malady

Summaries for Peptic Ulcer

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 A peptic ulcer is a sore in the lining of your stomach or your duodenum, the first part of your small intestine. a burning stomach pain is the most common symptom. the pain starts between meals or during the night briefly stops if you eat or take antacids lasts for minutes to hours comes and goes for several days or weeks peptic ulcers happen when the acids that help you digest food damage the walls of the stomach or duodenum. the most common cause is infection with a bacterium called helicobacter pylori. another cause is the long-term use of nonsteroidal anti-inflammatory medicines (nsaids) such as aspirin and ibuprofen. stress and spicy foods do not cause ulcers, but can make them worse. to see if you have an h. pylori infection, your doctor will test your blood, breath, or stool. your doctor also may look inside your stomach and duodenum by doing an endoscopy or x-ray. peptic ulcers will get worse if not treated. treatment may include medicines to reduce stomach acids or antibiotics to kill h. pylori. antacids and milk can't heal peptic ulcers. not smoking and avoiding alcohol can help. you may need surgery if your ulcers don't heal. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Peptic Ulcer, also known as acute peptic ulcer without hemorrhage and without perforation, is related to peptic ulcer perforation and gastric ulcer. An important gene associated with Peptic Ulcer is HRH2 (histamine receptor H2), and among its related pathways are Arachidonic acid metabolism and NF-kappa B signaling pathway. The drugs propantheline and propantheline bromide and the compounds pge2 and pepsinogen have been mentioned in the context of this disorder. Affiliated tissues include testes, small intestine and kidney, and related mouse phenotypes are immune system and homeostasis/metabolism.

Wikipedia:63 A peptic ulcer, stomach ulcer or gastric ulcer, also known as peptic ulcer disease (PUD), is a distinct... more...

Aliases & Classifications for Peptic Ulcer

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt
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Aliases & Descriptions:

peptic ulcer 8 10 44 33 60
acute peptic ulcer without hemorrhage and without perforation 8
acute peptic ulcer with hemorrhage and perforation 8
acute peptic ulcer with hemorrhage 8


External Ids:

Disease Ontology8 DOID:750
MeSH34 D010437
ICD9CM27 533
NCIt39 C3318

Related Diseases for Peptic Ulcer

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17GeneCards, 18GeneDecks
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Diseases related to Peptic Ulcer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 218)
idRelated DiseaseScoreTop Affiliating Genes
1peptic ulcer perforation31.6POMP
2gastric ulcer31.5PTGS2, S100A8, GAST, MUC5AC, CYP2C19, HRH2
3gastritis31.3S100A8, SCT, GAST, IL8
4duodenal ulcer31.1S100A8, SCT, GAST, HRH2
5duodenitis31.1ATP4A, GAST, S100A8
6dyspepsia30.9GAST, ATP4A, HRH2
7esophagitis30.8HRH2, CYP2C19, ATP4A, GAST, S100A8
8zollinger-ellison syndrome30.8SCT, GAST, HRH2
9gastroduodenitis30.8GAST
10duodenogastric reflux30.7GAST
11liver cirrhosis30.7SCT, CTSD, AKR1A1, MUC5AC, CD14, ALB
12hepatitis30.6HRH2, AKR1A1
13adenocarcinoma30.5S100A8, SCT, CTSD, GAST, MUC5AC, PTGS1
14pancreatitis30.5ALB, SCT
15peritonitis30.5ALB, CD14
16atrophic gastritis30.5S100A8, SCT, GAST, AKR1A1
17myocardial infarction30.5PTGS2, PTGS1, CD14, AKR1A1
18gastroesophageal reflux disease30.4S100A8, SCT, GAST, ATP4A, CYP2C19, HRH2
19barrett's esophagus30.4S100A8, GAST, MUC5AC, PTGS1, PTGS2
20gastric adenocarcinoma30.4S100A8, CTSD, GAST, HRH2, PTGS2
21stomach disease30.2HRH2, PTGS1, PTGS2
22hypertension30.2ALB
23acute myocardial infarction30.2CD14
24gastrinoma30.2SCT, GAST, ATP4A
25atherosclerosis30.2CDKN3, CD14, CXCL1, IL8, PTGS1, PTGS2
26inflammatory bowel disease30.0IL8
27periodontitis30.0IL8
28cholangiocarcinoma30.0PTGS2, MUC5AC, SCT
29encephalomyelitis30.0CXCL1
30acute pancreatitis30.0SCT, CD14, IL8, HRH2
31stomach cancer30.0S100A8, CTSD, GAST, HDC, MUC5AC, HRH2
32periodontal disease30.0PTGS1, IL8, CD14, S100A8
33adenoma30.0S100A8, SCT, CTSD, GAST, MUC5AC, CXCL1
34gastric outlet obstruction30.0GAST, ATP4A
35colon cancer30.0CTSD, GAST, CXCL1, PTGS1, PTGS2
36bile reflux30.0ATP4A
37ulcerative colitis30.0DEFA5, CD14, CXCL1, IL8
38pancreatic cancer30.0MUC5AC, GAST, SCT
39peptic esophagitis10.6
40active peptic ulcer disease10.6
41duodenal disease10.5
42liver disease10.4
43gastric lymphoma10.4
44esophageal disease10.3
45gallbladder disease10.3
46hiatus hernia10.3
47meckel's diverticulum10.3
48dumping syndrome10.3
49hepatitis a10.3
50islet cell tumor10.3

Graphical network of the top 20 diseases related to Peptic Ulcer:



Diseases related to peptic ulcer

Clinical Features for Peptic Ulcer

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Drugs & Therapeutics for Peptic Ulcer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Peptic Ulcer

Search NIH Clinical Center for Peptic Ulcer

Search CenterWatch for Peptic Ulcer

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Peptic Ulcer

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Anatomical Context for Peptic Ulcer

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32MalaCards
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MalaCards organs/tissues related to Peptic Ulcer:

32
Testes, Small intestine, Kidney, Liver, Heart, Pancreas, T cells, Colon, Endothelial, Myeloid, Ovary, Tongue

Animal Models for Peptic Ulcer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Peptic Ulcer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.3GAST, AKR1A1, ATP4A, HDC, MUC5AC, CD14
2MP:000537610.2ALB, SCT, CTSD, GAST, AKR1A1, ATP4A
3MP:000538110.0CTSD, GAST, ATP4A, MUC5AC, HRH2, PTGS1

Publications for Peptic Ulcer

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50PubMed
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Articles related to Peptic Ulcer:

(show top 50)    (show all 807)
idTitleAuthorsYear
1
Peptic ulcer disease: one in five is related to neither Helicobacter pylori nor aspirin/NSAID intake. (23981105)
2013
2
Effect of the Oral Intake of Probiotic Pediococcus acidilactici BA28 on Helicobacter pylori Causing Peptic Ulcer in C57BL/6 Mice Models. (24122711)
2013
3
Use of clopidogrel and proton pump inhibitors after a serious acute coronary event: risk of coronary events and peptic ulcer bleeding. (23884111)
2013
4
Effect of comorbidity on mortality in patients with peptic ulcer bleeding: systematic review and meta-analysis. (23381016)
2013
5
Duodenoportal fistula resulting from peptic ulcer after extended right hepatectomy for cholangiocarcinoma. (22524745)
2012
6
Is routine second-look endoscopy effective after endoscopic hemostasis in acute peptic ulcer bleeding? A meta-analysis. (22695209)
2012
7
Effects of Ramadan fasting on peptic ulcer disease as diagnosed by upper gastrointestinal endoscopy. (23432987)
2012
8
Risk factors influencing the outcome of peptic ulcer bleeding in end stage renal diseases after initial endoscopic haemostasis. (22650364)
2012
9
Clinical outcomes of the marginal ulcer bleeding after gastrectomy: as compared to the peptic ulcer bleeding with nonoperated stomach. (23304127)
2012
10
Time trends in epidemiology of peptic ulcer disease in India over two decades. (22766645)
2012
11
Should prophylactic low-dose aspirin therapy be continued in peptic ulcer bleeding? (21175237)
2011
12
Fermented soybean liquid alleviated peptic ulcer through the destruction of acidic proton pump rather than suppression of urease of Helicobacter pylori: a kinetic analysis. (21591741)
2011
13
Laparoscopic simple closure alone is adequate for low risk patients with perforated peptic ulcer. (21533964)
2011
14
Helicobacter pylori infection in bleeding peptic ulcer patients after non-steroidal antiinflammatory drug consumption. (22110282)
2011
15
Second-line levofloxacin-based triple therapy's efficiency for Helicobacter pylori eradication in patients with peptic ulcer. (21886067)
2011
16
Long-term peptic ulcer rebleeding risk estimation in patients undergoing haemodialysis: a 10-year nationwide cohort study. (21266725)
2011
17
Low prevalence of idiopathic peptic ulcer disease: an Italian endoscopic survey. (20444661)
2010
18
Laparoscopic repair of perforated peptic duodenal ulcer. (20402333)
2010
19
Aspirin withdrawal in acute peptic ulcer bleeding: are we harming patients? (19949134)
2010
20
Correlation of CYP2C19 genetic polymorphisms with helicobacter pylori eradication in patients with cirrhosis and peptic ulcer. (20457439)
2010
21
Second-look endoscopy with thermal coagulation or injections for peptic ulcer bleeding: a meta-analysis. (20136971)
2010
22
Interval hypoxic training in complex treatment of Helicobacter pylori-associated peptic ulcer disease. (20532252)
2010
23
Association between clinical manifestations of complicated and uncomplicated peptic ulcer and visceral sensory dysfunction. (20594234)
2010
24
Upper gastrointestinal bleeding in a patient with a history of peptic ulcer disease: don't presume the diagnosis. (20065905)
2010
25
Effect of yiqi huoxue formula on healing quality and recurrence rate of peptic ulcer]. (20214327)
2009
26
Risk factors in patients surgically treated for peptic ulcer perforation. (18785067)
2009
27
Perforated peptic ulcer: "developing" world versus "developed" world. (18979130)
2009
28
The preventive factors for aspirin-induced peptic ulcer: aspirin ulcer and corpus atrophy. (19448967)
2009
29
What is the best strategy for diagnosis and treatment of Helicobacter pylori in the prevention of recurrent peptic ulcer bleeding? A cost-effectiveness analysis. (19490560)
2009
30
Uncomplicated peptic ulcer in the UK: trends from 1997 to 2005. (19709097)
2009
31
Gastrointestinal bleeding: adjuvant pharmacotherapy for peptic ulcer bleeding. (19654601)
2009
32
H. pylori should be eradicated in chronic liver disease patients with peptic ulcer. (19112053)
2009
33
Birth-cohort patterns of mortality from ulcerative colitis and peptic ulcer. (18922397)
2008
34
Hospital case volume and clinical outcomes for peptic ulcer treatment. (18648892)
2008
35
Analysis of Pro12Ala PPAR gamma polymorphism and Helicobacter pylori infection in gastric adenocarcinoma and peptic ulcer disease. (18372284)
2008
36
Proton pump inhibitors and recurrent bleeding in peptic ulcer disease. (19120905)
2008
37
Prognostic factors in gastrointestinal bleeding due to peptic ulcer: construction of a predictive model. (18580501)
2008
38
Eradication of Helicobacter pylori for the prevention of peptic ulcer rebleeding. (18715399)
2008
39
Gastritis, dyspepsia and peptic ulcer disease. (18497728)
2008
40
Consensus and variable region PCR analysis of Helicobacter pylori 3' region of cagA gene in isolates from individuals with or without peptic ulcer. (11158115)
2001
41
One Hundred Years of Discovery and Rediscovery of Helicobacter pylori and Its Association with Peptic Ulcer Disease (21290733)
2001
42
The CLO test is unreliable in diagnosing H. pylori infection in post-surgical stomach; is there any role of H. pylori in peptic ulcer recurrence? (10656217)
2000
43
Association of peptic ulcer with increased expression of Lewis antigens but not cagA, iceA, and vacA in Helicobacter pylori isolates in an Asian population. (10861258)
2000
44
Helicobacter pylori cytotoxic genotype is associated with peptic ulcer and influences serology. (9468248)
1998
45
The characteristics of duodenogastric reflux in peptic ulcer and chronic gastritis]. (8160143)
1994
46
Short-term results of gastrectomy with Roux-en-Y or Billroth II anastomosis for peptic ulcer. A prospective comparative study. (1568701)
1992
47
Peptic ulcer perforation: a complication of double contrast barium meal examination. (2799373)
1989
48
Famotidine. Pharmacodynamic and pharmacokinetic properties and a preliminary review of its therapeutic use in peptic ulcer disease and Zollinger-Ellison syndrome. (2875864)
1986
49
Non-steroidal anti-inflammatory drugs and peptic ulcer perforation. (3949230)
1986
50
Peptic esophagitis and peptic ulcer of the esophagus. (13213337)
1954

Genetic Variations for Peptic Ulcer

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Expression for genes affiliated with Peptic Ulcer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Peptic Ulcer

Search GEO for disease gene expression data for Peptic Ulcer.

Pathways for genes affiliated with Peptic Ulcer

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53Reactome, 12EMD Millipore, 29KEGG, 37NCBI BioSystems Database
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Pathways related to Peptic Ulcer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4CYP2C19, PTGS1, PTGS2
210.4PTGS2, IL8, CD14
310.4PTGS1, PTGS2, ALB
410.4IL8, CXCL1, CD14
510.4IL8, CXCL1, CD14
6
Cytokine production by Th17 cells in CF (Mouse model)
10.4CD14, CXCL1, IL8
7
Hide members
10.4PTGS2, PTGS1, AKR1A1

Compounds for genes affiliated with Peptic Ulcer

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Peptic Ulcer according to GeneCards/GeneDecks:

(show top 50)    (show all 206)
idCompoundScoreTop Affiliating Genes
1pge24410.9PTGS2
2pepsinogen4410.9GAST, HRH2, SCT, CTSD
3Acetylsalicylic acid1110.8ALB, PTGS2, PTGS1, CYP2C19
4clarithromycin44 1111.8CYP2C19, HRH2, IL8, GAST, S100A8
5ranitidine44 28 11 2413.8GAST, HRH2, CYP2C19, AKR1A1, SCT
6amoxicillin44 49 1112.8CYP2C19, S100A8, GAST, HRH2
7pantoprazole44 49 11 2413.8GAST, ATP4A, CYP2C19, HRH2
8acetaminophen44 2 49 11 2414.8CYP2C19, HRH2
9omeprazole44 28 49 11 2414.8SCT, GAST, ATP4A, HDC, HRH2, CYP2C19
10diclofenac44 28 49 1113.8ALB, PTGS2, PTGS1, HRH2, CYP2C19
11Magnesium salicylate1110.8PTGS2, ALB, PTGS1
12cimetidine44 28 1112.8SCT, GAST, AKR1A1, CYP2C19, HRH2
13lansoprazole49 44 11 2413.8GAST, ATP4A, CYP2C19, HRH2
14antipyrine44 1111.8PTGS2, ALB, PTGS1, CYP2C19
15dexamethasone44 49 28 1113.8S100A8, MUC5AC, CD14, CYP2C19, CXCL1, PTGS2
16fenoprofen28 44 1112.8PTGS2, PTGS1, ALB
17celecoxib44 59 28 49 11 2415.8GAST, HRH2, PTGS1, PTGS2, ALB
18indomethacin44 59 28 1113.8SCT, AKR1A1, ALB, CDKN3, CYP2C19, PTGS1
19ethanol44 49 11 2413.8CTSD, SCT, AKR1A1, MUC5AC, CYP2C19, HRH2
20lactate4410.8IL8, PTGS1, ALB, CTSD, AKR1A1, HRH2
21bicarbonate4410.8SCT, ALB, GAST, HRH2, AKR1A1
22esomeprazole44 49 1112.7ATP4A, GAST, CYP2C19
23lumiracoxib44 28 1112.7PTGS2, PTGS1, CYP2C19
24aspartate4410.7AKR1A1, HDC, CTSD, SCT, CD14, ALB
25lafutidine4410.7GAST, SCT, HRH2
26serine4410.7AKR1A1, MUC5AC, PTGS1, SCT, S100A8, CDKN3
27rantes4410.7CD14, CXCL1, HDC, SCT, S100A8
28triptolide4410.7IL8, PTGS1, PTGS2, CD14
29oxygen44 2411.7HRH2, IL8, S100A8, CTSD, CYP2C19, PTGS1
30histamine44 28 2412.7SCT, GAST, AKR1A1, HDC, MUC5AC, CD14
31retinoic acid44 2411.7CXCL1, CTSD, S100A8, MUC5AC, HDC, CD14
32nitric oxide44 11 2412.7MUC5AC, IL8, PTGS2, CXCL1, S100A8, CTSD
33cyclosporin a44 28 5912.7CTSD, SCT, CDKN3, IL8, CXCL1, CYP2C19
34tolmetin44 1111.7ALB, PTGS1, PTGS2
35cysteine4410.7IL8, CXCL1, CD14, MUC5AC, AKR1A1, ALB
36sulfasalazine44 28 49 1113.7PTGS2, PTGS1, IL8, CXCL1
37alanine4410.7CTSD, GAST, AKR1A1, S100A8, PTGS1, HDC
38bismuth44 2411.7GAST, HRH2, ALB
39glutamate4410.6SCT, GAST, HDC, AKR1A1
40vegf4410.6PTGS2, PTGS1, IL8, CTSD, CXCL1, CD14
41creatinine4410.6ALB, HRH2, CD14, S100A8, CTSD, GAST
42fosphenytoin44 1111.6CYP2C19, CDKN3, ALB
43valdecoxib44 28 11 2413.6PTGS2, PTGS1, CYP2C19
44etoricoxib44 28 1112.5CYP2C19, PTGS1, PTGS2
45adenylate4410.5CDKN3, SCT, HRH2, CXCL1, CTSD, GAST
46diflunisal44 1111.5PTGS1, PTGS2, ALB
47suprofen44 1111.4ALB, PTGS1, PTGS2
48herbimycin a44 5911.4CDKN3, CD14, IL8, PTGS2, PTGS1
49calcium44 49 11 2413.2CTSD, SCT, S100A8, ALB, MUC5AC, CDKN3
50pd 98,0594410.1CXCL1, CD14, IL8, MUC5AC, PTGS2, SCT

GO Terms for genes affiliated with Peptic Ulcer

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16Gene Ontology
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Cellular components related to Peptic Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.3CTSD, DEFA5, CD14, CXCL1, IL8, ALB
2extracellular regionGO:00557610.0ALB, S100A8, SCT, CTSD, GAST, DEFA5

Biological processes related to Peptic Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclooxygenase pathwayGO:01937110.4PTGS2, PTGS1
2inflammatory responseGO:00695410.3PTGS2, IL8, CXCL1, CD14, S100A8
3arachidonic acid metabolic processGO:01936910.1CYP2C19, PTGS1, PTGS2

Molecular functions related to Peptic Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prostaglandin-endoperoxide synthase activityGO:00466610.4PTGS2, PTGS1

Products for genes affiliated with Peptic Ulcer

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  • Antibodies
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  • Antibodies

Sources for Peptic Ulcer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet