MCID: PPT003
MIFTS: 55

Peptic Ulcer malady

Summaries for Peptic Ulcer

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 A peptic ulcer is a sore in the lining of your stomach or your duodenum, the first part of your small intestine. a burning stomach pain is the most common symptom. the pain starts between meals or during the night briefly stops if you eat or take antacids lasts for minutes to hours comes and goes for several days or weeks peptic ulcers happen when the acids that help you digest food damage the walls of the stomach or duodenum. the most common cause is infection with a bacterium called helicobacter pylori. another cause is the long-term use of nonsteroidal anti-inflammatory medicines (nsaids) such as aspirin and ibuprofen. stress and spicy foods do not cause ulcers, but can make them worse. to see if you have an h. pylori infection, your doctor will test your blood, breath, or stool. your doctor also may look inside your stomach and duodenum by doing an endoscopy or x-ray. peptic ulcers will get worse if not treated. treatment may include medicines to reduce stomach acids or antibiotics to kill h. pylori. antacids and milk can't heal peptic ulcers. not smoking and avoiding alcohol can help. you may need surgery if your ulcers don't heal. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Peptic Ulcer, also known as acute peptic ulcer without hemorrhage and without perforation, is related to gastric ulcer and peptic ulcer perforation. An important gene associated with Peptic Ulcer is HRH2 (histamine receptor H2), and among its related pathways are Arachidonic acid metabolism and NF-kappa B signaling pathway. The drugs propantheline and propantheline bromide and the compounds pge2 and pepsinogen have been mentioned in the context of this disorder. Related mouse phenotypes are immune system and homeostasis/metabolism.

Wikipedia:64 A peptic ulcer, stomach ulcer or gastric ulcer, also known as peptic ulcer disease (PUD), is a distinct... more...

Aliases & Classifications for Peptic Ulcer

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt
See all sources

Aliases & Descriptions:

peptic ulcer 8 10 45 34 61
acute peptic ulcer without hemorrhage and without perforation 8
acute peptic ulcer with hemorrhage and perforation 8
acute peptic ulcer with hemorrhage 8


External Ids:

Disease Ontology8 DOID:750
MeSH35 D010437
ICD9CM27 533
NCIt40 C3318

Related Diseases for Peptic Ulcer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Peptic Ulcer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 205)
idRelated DiseaseScoreTop Affiliating Genes
1gastric ulcer31.6PTGS2, S100A8, GAST, MUC5AC, CYP2C19, HRH2
2peptic ulcer perforation31.4POMP
3duodenal ulcer31.1S100A8, SCT, GAST, HRH2
4dyspepsia30.9GAST, ATP4A, HRH2
5zollinger-ellison syndrome30.9SCT, GAST, HRH2
6duodenogastric reflux30.8GAST
7duodenitis30.7ATP4A, GAST, S100A8
8gastric outlet obstruction30.7GAST, ATP4A
9gastroduodenitis30.6GAST
10adenocarcinoma30.6S100A8, SCT, CTSD, GAST, MUC5AC, PTGS1
11atrophic gastritis30.5S100A8, SCT, GAST, AKR1A1
12gastroesophageal reflux disease30.4S100A8, SCT, GAST, ATP4A, CYP2C19, HRH2
13barrett's esophagus30.4S100A8, GAST, MUC5AC, PTGS1, PTGS2
14stomach disease30.3HRH2, PTGS1, PTGS2
15acute myocardial infarction30.3CD14
16gastrinoma30.3SCT, GAST, ATP4A
17atherosclerosis30.3CDKN3, CD14, CXCL1, IL8, PTGS1, PTGS2
18coronary heart disease30.1AKR1A1
19acute pancreatitis30.1SCT, CD14, IL8, HRH2
20stomach cancer30.1S100A8, CTSD, GAST, HDC, MUC5AC, HRH2
21adenoma30.1S100A8, SCT, CTSD, GAST, MUC5AC, CXCL1
22bile reflux30.1ATP4A
23ulcerative colitis30.1DEFA5, CD14, CXCL1, IL8
24h. pylori infection10.9
25peptic esophagitis10.6
26active peptic ulcer disease10.5
27gastric lymphoma10.4
28dumping syndrome10.3
29chronic erosive gastritis10.3
30pernicious anemia10.2
31aortic disease10.2
32pulmonary disease, chronic obstructive10.2
33somatostatin analog10.2
34teratoma10.2
35neurofibromatosis10.1
36ascariasis10.1
37hepatitis c10.1
38radiation cystitis10.1
39porphyria cutanea tarda10.1
40gastric dilatation10.1
41hypochondriasis10.1
42neurodermatitis10.1
43primary hyperparathyroidism10.1
44superior mesenteric artery syndrome10.1
45fatty liver disease10.1
46meckel's diverticulum10.1
47wernicke encephalopathy10.1
48primary ciliary dyskinesia10.1
49tuberculoid leprosy10.1
50borderline leprosy10.1

Graphical network of the top 20 diseases related to Peptic Ulcer:



Diseases related to peptic ulcer

Clinical Features for Peptic Ulcer

Drugs & Therapeutics for Peptic Ulcer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Peptic Ulcer

Drug clinical trials:

Search ClinicalTrials for Peptic Ulcer

Search NIH Clinical Center for Peptic Ulcer

Search CenterWatch for Peptic Ulcer

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Peptic Ulcer

Anatomical Context for Peptic Ulcer

Animal Models for Peptic Ulcer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Peptic Ulcer:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.3HDC, PTGS2, PTGS1, IL8, CD14, CTSD
2MP:000537610.2SCT, ALB, PTGS2, PTGS1, HRH2, CD14
3MP:000538110.0ALB, PTGS2, PTGS1, HRH2, MUC5AC, ATP4A

Publications for Peptic Ulcer

Sources:
51PubMed
See all sources

Articles related to Peptic Ulcer:

(show top 50)    (show all 811)
idTitleAuthorsYear
1
Fluoxetine inhibition of CYP3A4 potentiating adrenal suppression and peptic ulcer disease from intra-articular triamcinolone injections. (23565802)
2013
2
15-PGDH inhibitors: the antiulcer effects of carbenoxolone, pioglitazone and verapamil in indomethacin induced peptic ulcer rats. (23884819)
2013
3
Restoring psychology's role in peptic ulcer. (23457084)
2013
4
Spontaneous pneumobilia revealing choledocho-duodenal fistula: A rare complication of peptic ulcer disease. (23723630)
2013
5
Association of SLCO1B1 1b with peptic ulcer amongst Japanese patients taking low-dose aspirin. (22088425)
2012
6
Different risk factors influence peptic ulcer disease development in a Brazilian population. (23082057)
2012
7
Increased numbers of Foxp3-positive regulatory T cells in gastritis, peptic ulcer and gastric adenocarcinoma. (22228968)
2012
8
Systematic review of peptic ulcer disease incidence rates: do studies without validation provide reliable estimates? (21626606)
2011
9
Endovascular management of peptic ulcer bleeding: maximizing results and minimizing recurrent bleeding. (21802594)
2011
10
Systematic review of the epidemiology of complicated peptic ulcer disease: incidence, recurrence, risk factors and mortality. (21494041)
2011
11
Bleeding peptic ulcer: characteristics and outcomes in Newcastle, NSW. (21040320)
2011
12
Antiplatelet and anticoagulant therapy in patients with gastrointestinal bleeding: an 86-year-old woman with peptic ulcer disease. (22045703)
2011
13
Birth cohort patterns of gastric cancer and peptic ulcer among non-whites in the USA. (21597103)
2011
14
Multicentre trial of a perioperative protocol to reduce mortality in patients with peptic ulcer perforation. (21442610)
2011
15
Perforated peptic ulcer disease: mid-term outcome among Iranian population. (20872324)
2010
16
Gedunin and photogedunin of Xylocarpus granatum show significant anti-secretory effects and protect the gastric mucosa of peptic ulcer in rats. (19962286)
2010
17
Perforated peptic ulcer: how to improve outcome? (18752147)
2009
18
Predictive model for length of hospital stay of patients surviving surgery for perforated peptic ulcer. (19666352)
2009
19
Peptic ulcer disease and its complications. (19702095)
2009
20
Oral or intravenous proton pump inhibitor in patients with peptic ulcer bleeding after successful endoscopic epinephrine injection. (19523014)
2009
21
Peptic ulcer and childhood adversities experienced by working-aged people. (19610142)
2009
22
Perforated peptic ulcer: clinical presentation, surgical outcomes, and the accuracy of the Boey scoring system in predicting postoperative morbidity and mortality. (18958520)
2009
23
Diverse characteristics of the CagA gene of Helicobacter pylori strains collected from patients from southern vietnam with gastric cancer and peptic ulcer. (19846630)
2009
24
Intermittent versus continuous pantoprazole infusion in peptic ulcer bleeding: a prospective randomized study. (18824852)
2008
25
Quadruple therapy with furazolidone for retreatment in patients with peptic ulcer disease. (18985815)
2008
26
Perforated peptic ulcer associated with abdominal compartment syndrome. (19091294)
2008
27
Endoscopic hemostasis by using the TriClip for peptic ulcer hemorrhage: a pilot study. (17945225)
2008
28
Clinical trial: the incidence and early mortality after peptic ulcer perforation, and the use of low-dose aspirin and nonsteroidal anti-inflammatory drugs. (18644010)
2008
29
Laparoscopic repair of peptic ulcer perforation without omental patch versus conventional open repair. (17907974)
2007
30
Difference analysis on proteome of Helicobacter pylori in patients with peptic ulcer, gastritis, and gastric cancer]. (17199978)
2006
31
Perforated peptic duodenal ulcer in a paraesophageal hernia--a case report of a rare surgical emergency. (16438731)
2006
32
Helicobacter pylori cagA, iceA and vacA status in Taiwanese patients with peptic ulcer and gastritis. (14535980)
2003
33
The evolving management of gastric outlet obstruction from peptic ulcer disease. (16093176)
2002
34
Co-expression in Helicobacter pylori of cagA and non-opsonic neutrophil activation enhances the association with peptic ulcer disease. (10823130)
2000
35
How to achieve a near 100% cure rate for H. pylori infection in peptic ulcer patients. A personal viewpoint. (8771431)
1996
36
Influence of Helicobacter pylori on tryptase and cathepsin D in peptic ulcer. (7587835)
1995
37
Are tryptase and cathepsin D related to Helicobacter pylori infection and mucosal gastrin in peptic ulcer? (8202635)
1994
38
Acanthamoeba infection of peptic ulcer. (8250632)
1993
39
Current management of bleeding peptic ulcer. A review. (7691516)
1993
40
Endoscopic stage classification of peptic ulcer and characterization of the healing process by proton pump inhibitors]. (1347333)
1992
41
Intestinal ascariasis in the differential diagnosis of peptic ulcer disease. (2260195)
1990
42
Somatostatin release by human gastric mucosa. Studies in peptic ulcer disease and pernicious anemia. (2902682)
1988
43
Immunopathology of peptic ulcer disease and duodenitis (bulbitis). (3481875)
1987
44
The nature of gastric secretions in a patient with Zollinger-Ellison syndrome without peptic ulceration. (3757267)
1986
45
Proximal gastric vagotomy in emergency peptic ulcer perforation. (3787427)
1986
46
Omeprazole. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in peptic ulcer disease and Zollinger-Ellison syndrome. (3527658)
1986
47
Relevance of duodenitis to non-ulcer dyspepsia and peptic ulceration. (6962536)
1982
48
The relationship between active peptic ulcer, endoscopic duodenitis and symptomatic state after treatment with cimetidine. (6990861)
1980
49
Hiatal hernia complex; hiatal hernia, peptic esophagitis, Mallory-Weiss syndrome, hemorrhage and anemia, and marginal esophagogastric ulcer. (13357312)
1956
50
Evaluation of clinical methods in gastro-intestinal disease. IV. Autopsy findings of liver disease (fatty infiltration, hepatic cirrhosis) observed in peptic ulcer cases. (14885142)
1951

Genetic Variations for Peptic Ulcer

Expression for genes affiliated with Peptic Ulcer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Peptic Ulcer

Search GEO for disease gene expression data for Peptic Ulcer.

Pathways for genes affiliated with Peptic Ulcer

Sources:
54Reactome, 12EMD Millipore, 30KEGG, 38NCBI BioSystems Database
See all sources

Pathways related to Peptic Ulcer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4CYP2C19, PTGS1, PTGS2
210.4PTGS2, IL8, CD14
310.4PTGS1, PTGS2, ALB
410.4IL8, CXCL1, CD14
510.4IL8, CXCL1, CD14
6
Cytokine production by Th17 cells in CF (Mouse model)
10.4CD14, CXCL1, IL8
7
Hide members
10.4PTGS2, PTGS1, AKR1A1

Compounds for genes affiliated with Peptic Ulcer

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 50PharmGKB, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Peptic Ulcer according to GeneCards/GeneDecks:

(show top 50)    (show all 206)
idCompoundScoreTop Affiliating Genes
1pge24510.9PTGS2
2pepsinogen4510.9GAST, HRH2, SCT, CTSD
3Acetylsalicylic acid1110.8ALB, PTGS2, PTGS1, CYP2C19
4clarithromycin45 1111.8CYP2C19, HRH2, IL8, GAST, S100A8
5ranitidine45 29 11 2413.8GAST, HRH2, CYP2C19, AKR1A1, SCT
6amoxicillin45 50 1112.8CYP2C19, S100A8, GAST, HRH2
7pantoprazole45 50 11 2413.8GAST, ATP4A, CYP2C19, HRH2
8acetaminophen45 2 50 11 2414.8CYP2C19, HRH2
9omeprazole45 29 50 11 2414.8SCT, GAST, ATP4A, HDC, HRH2, CYP2C19
10diclofenac45 29 50 1113.8ALB, PTGS2, PTGS1, HRH2, CYP2C19
11Magnesium salicylate1110.8PTGS2, ALB, PTGS1
12cimetidine45 29 1112.8SCT, GAST, AKR1A1, CYP2C19, HRH2
13lansoprazole50 45 11 2413.8GAST, ATP4A, CYP2C19, HRH2
14antipyrine45 1111.8PTGS2, ALB, PTGS1, CYP2C19
15dexamethasone45 50 29 1113.8S100A8, MUC5AC, CD14, CYP2C19, CXCL1, PTGS2
16fenoprofen29 45 1112.8PTGS2, PTGS1, ALB
17celecoxib45 60 29 50 11 2415.8GAST, HRH2, PTGS1, PTGS2, ALB
18indomethacin45 60 29 1113.8SCT, AKR1A1, ALB, CDKN3, CYP2C19, PTGS1
19ethanol45 50 11 2413.8CTSD, SCT, AKR1A1, MUC5AC, CYP2C19, HRH2
20lactate4510.8IL8, PTGS1, ALB, CTSD, AKR1A1, HRH2
21bicarbonate4510.8SCT, ALB, GAST, HRH2, AKR1A1
22esomeprazole45 50 1112.7ATP4A, GAST, CYP2C19
23lumiracoxib45 29 1112.7PTGS2, PTGS1, CYP2C19
24aspartate4510.7AKR1A1, HDC, CTSD, SCT, CD14, ALB
25lafutidine4510.7GAST, SCT, HRH2
26serine4510.7AKR1A1, MUC5AC, PTGS1, SCT, S100A8, CDKN3
27rantes4510.7CD14, CXCL1, HDC, SCT, S100A8
28triptolide4510.7IL8, PTGS1, PTGS2, CD14
29oxygen45 2411.7HRH2, IL8, S100A8, CTSD, CYP2C19, PTGS1
30histamine45 29 2412.7SCT, GAST, AKR1A1, HDC, MUC5AC, CD14
31retinoic acid45 2411.7CXCL1, CTSD, S100A8, MUC5AC, HDC, CD14
32nitric oxide45 11 2412.7MUC5AC, IL8, PTGS2, CXCL1, S100A8, CTSD
33cyclosporin a45 29 6012.7CTSD, SCT, CDKN3, IL8, CXCL1, CYP2C19
34tolmetin45 1111.7ALB, PTGS1, PTGS2
35cysteine4510.7IL8, CXCL1, CD14, MUC5AC, AKR1A1, ALB
36sulfasalazine45 29 50 1113.7PTGS2, PTGS1, IL8, CXCL1
37alanine4510.7CTSD, GAST, AKR1A1, S100A8, PTGS1, HDC
38bismuth45 2411.7GAST, HRH2, ALB
39glutamate4510.6SCT, GAST, HDC, AKR1A1
40vegf4510.6PTGS2, PTGS1, IL8, CTSD, CXCL1, CD14
41creatinine4510.6ALB, HRH2, CD14, S100A8, CTSD, GAST
42fosphenytoin45 1111.6CYP2C19, CDKN3, ALB
43valdecoxib45 29 11 2413.6PTGS2, PTGS1, CYP2C19
44etoricoxib45 29 1112.5CYP2C19, PTGS1, PTGS2
45adenylate4510.5CDKN3, SCT, HRH2, CXCL1, CTSD, GAST
46diflunisal45 1111.5PTGS1, PTGS2, ALB
47suprofen45 1111.4ALB, PTGS1, PTGS2
48herbimycin a45 6011.4CDKN3, CD14, IL8, PTGS2, PTGS1
49calcium45 50 11 2413.2CTSD, SCT, S100A8, ALB, MUC5AC, CDKN3
50pd 98,0594510.1CXCL1, CD14, IL8, MUC5AC, PTGS2, SCT

GO Terms for genes affiliated with Peptic Ulcer

Sources:
16Gene Ontology
See all sources

Cellular components related to Peptic Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.3CTSD, DEFA5, CD14, CXCL1, IL8, ALB
2extracellular regionGO:00557610.0ALB, S100A8, SCT, CTSD, GAST, DEFA5

Biological processes related to Peptic Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclooxygenase pathwayGO:01937110.4PTGS2, PTGS1
2inflammatory responseGO:00695410.3PTGS2, IL8, CXCL1, CD14, S100A8
3arachidonic acid metabolic processGO:01936910.1CYP2C19, PTGS1, PTGS2

Molecular functions related to Peptic Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prostaglandin-endoperoxide synthase activityGO:00466610.4PTGS2, PTGS1

Products for genes affiliated with Peptic Ulcer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Peptic Ulcer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet