MCID: PPT003
MIFTS: 61

Peptic Ulcer malady

Summaries for Peptic Ulcer

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 A peptic ulcer is a sore in the lining of your stomach or your duodenum, the first part of your small intestine. a burning stomach pain is the most common symptom. the pain starts between meals or during the night briefly stops if you eat or take antacids lasts for minutes to hours comes and goes for several days or weeks peptic ulcers happen when the acids that help you digest food damage the walls of the stomach or duodenum. the most common cause is infection with a bacterium called helicobacter pylori. another cause is the long-term use of nonsteroidal anti-inflammatory medicines (nsaids) such as aspirin and ibuprofen. stress and spicy foods do not cause ulcers, but can make them worse. to see if you have an h. pylori infection, your doctor will test your blood, breath, or stool. your doctor also may look inside your stomach and duodenum by doing an endoscopy or x-ray. peptic ulcers will get worse if not treated. treatment may include medicines to reduce stomach acids or antibiotics to kill h. pylori. antacids and milk can't heal peptic ulcers. not smoking and avoiding alcohol can help. you may need surgery if your ulcers don't heal. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Peptic Ulcer, also known as acute peptic ulcer without hemorrhage and without perforation, is related to peptic ulcer perforation and gastric ulcer. An important gene associated with Peptic Ulcer is HRH2 (histamine receptor H2), and among its related pathways are Arachidonic acid metabolism and NF-kappa B signaling pathway. The drugs propantheline and propantheline bromide and the compounds pge2 and pepsinogen have been mentioned in the context of this disorder. Affiliated tissues include testes, small intestine and kidney, and related mouse phenotypes are immune system and homeostasis/metabolism.

Wikipedia:63 A peptic ulcer, stomach ulcer or gastric ulcer, also known as peptic ulcer disease (PUD), is a distinct... more...

Aliases & Classifications for Peptic Ulcer

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt
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Aliases & Descriptions:

peptic ulcer 8 10 44 33 60
acute peptic ulcer without hemorrhage and without perforation 8
acute peptic ulcer with hemorrhage and perforation 8
acute peptic ulcer with hemorrhage 8


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Disease Ontology8 DOID:750
MeSH34 D010437
ICD9CM27 533
NCIt39 C3318

Related Diseases for Peptic Ulcer

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17GeneCards, 18GeneDecks
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Diseases related to Peptic Ulcer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 218)
idRelated DiseaseScoreTop Affiliating Genes
1peptic ulcer perforation31.6POMP
2gastric ulcer31.5PTGS2, S100A8, GAST, MUC5AC, CYP2C19, HRH2
3gastritis31.3S100A8, SCT, GAST, IL8
4duodenal ulcer31.1S100A8, SCT, GAST, HRH2
5duodenitis31.1ATP4A, GAST, S100A8
6dyspepsia30.9GAST, ATP4A, HRH2
7esophagitis30.8HRH2, CYP2C19, ATP4A, GAST, S100A8
8zollinger-ellison syndrome30.8SCT, GAST, HRH2
9gastroduodenitis30.8GAST
10duodenogastric reflux30.7GAST
11liver cirrhosis30.7SCT, CTSD, AKR1A1, MUC5AC, CD14, ALB
12hepatitis30.6HRH2, AKR1A1
13adenocarcinoma30.5S100A8, SCT, CTSD, GAST, MUC5AC, PTGS1
14pancreatitis30.5ALB, SCT
15peritonitis30.5ALB, CD14
16atrophic gastritis30.5S100A8, SCT, GAST, AKR1A1
17myocardial infarction30.5PTGS2, PTGS1, CD14, AKR1A1
18gastroesophageal reflux disease30.4S100A8, SCT, GAST, ATP4A, CYP2C19, HRH2
19barrett's esophagus30.4S100A8, GAST, MUC5AC, PTGS1, PTGS2
20gastric adenocarcinoma30.4S100A8, CTSD, GAST, HRH2, PTGS2
21stomach disease30.2HRH2, PTGS1, PTGS2
22hypertension30.2ALB
23acute myocardial infarction30.2CD14
24gastrinoma30.2SCT, GAST, ATP4A
25atherosclerosis30.2CDKN3, CD14, CXCL1, IL8, PTGS1, PTGS2
26inflammatory bowel disease30.0IL8
27periodontitis30.0IL8
28cholangiocarcinoma30.0PTGS2, MUC5AC, SCT
29encephalomyelitis30.0CXCL1
30acute pancreatitis30.0SCT, CD14, IL8, HRH2
31stomach cancer30.0S100A8, CTSD, GAST, HDC, MUC5AC, HRH2
32periodontal disease30.0PTGS1, IL8, CD14, S100A8
33adenoma30.0S100A8, SCT, CTSD, GAST, MUC5AC, CXCL1
34gastric outlet obstruction30.0GAST, ATP4A
35colon cancer30.0CTSD, GAST, CXCL1, PTGS1, PTGS2
36bile reflux30.0ATP4A
37ulcerative colitis30.0DEFA5, CD14, CXCL1, IL8
38pancreatic cancer30.0MUC5AC, GAST, SCT
39peptic esophagitis10.6
40active peptic ulcer disease10.6
41duodenal disease10.5
42liver disease10.4
43gastric lymphoma10.4
44esophageal disease10.3
45gallbladder disease10.3
46hiatus hernia10.3
47meckel's diverticulum10.3
48dumping syndrome10.3
49hepatitis a10.3
50islet cell tumor10.3

Graphical network of the top 20 diseases related to Peptic Ulcer:



Diseases related to peptic ulcer

Clinical Features for Peptic Ulcer

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Drugs & Therapeutics for Peptic Ulcer

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Peptic Ulcer

Search NIH Clinical Center for Peptic Ulcer

Search CenterWatch for Peptic Ulcer

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Peptic Ulcer

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Anatomical Context for Peptic Ulcer

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32MalaCards
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MalaCards organs/tissues related to Peptic Ulcer:

32
Testes, Small intestine, Kidney, Liver, Heart, Pancreas, T cells, Colon, Endothelial, Myeloid, Ovary, Tongue

Animal Models for Peptic Ulcer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Peptic Ulcer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.3GAST, AKR1A1, ATP4A, HDC, MUC5AC, CD14
2MP:000537610.2ALB, SCT, CTSD, GAST, AKR1A1, ATP4A
3MP:000538110.0CTSD, GAST, ATP4A, MUC5AC, HRH2, PTGS1

Publications for Peptic Ulcer

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50PubMed
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Articles related to Peptic Ulcer:

(show top 50)    (show all 807)
idTitleAuthorsYear
1
Comparison of intravenous pantoprazole with intravenous ranitidine in peptic ulcer bleeding. (24214585)
2013
2
Quality-of-care initiative in patients treated surgically for perforated peptic ulcer. (23288621)
2013
3
End-stage renal disease is associated with worse outcomes in hospitalized patients with peptic ulcer bleeding. (23357495)
2013
4
Long-term risk of recurrent peptic ulcer bleeding in patients with liver cirrhosis: a 10-year nationwide cohort study. (22378148)
2012
5
Investigation of ABCB1 1236 and 2677 SNPs in patients with peptic ulcer. (22087845)
2012
6
Secreted and membrane-bound mucins and idiopathic peptic ulcer disease. (23075498)
2012
7
Increased numbers of Foxp3-positive regulatory T cells in gastritis, peptic ulcer and gastric adenocarcinoma. (22228968)
2012
8
Serum sTREM-1 as a surrogate marker of treatment outcome in patients with peptic ulcer disease. (21633832)
2011
9
Efficacy of Helicobacter pylori eradication therapy in cirrhotic patients with peptic ulcer disease. (21870725)
2011
10
Has H. pylori prevalence in bleeding peptic ulcer been underestimated? A meta-regression. (21304499)
2011
11
Perforated peptic ulcer (PPU) in pregnancy during Ramadan fasting. (21970248)
2011
12
Multicentre trial of a perioperative protocol to reduce mortality in patients with peptic ulcer perforation. (21442610)
2011
13
Preadmission use of systemic glucocorticoids and 30-day mortality following bleeding peptic ulcer: a population-based cohort study. (19531935)
2010
14
Comparison of peptic ulcer disease risk between peritoneal and hemodialysis patients. (20639629)
2010
15
Helicobacter pylori reinfection in Brazilian patients with peptic ulcer disease: a 5-year follow-up. (20302589)
2010
16
Endoscopic therapy for peptic ulcer hemorrhage: practice variations in a multi-center U.S. consortium. (20585979)
2010
17
Formation of gastrocolic fistula during treatment for peptic ulcer. (19691773)
2009
18
Serum levels of high-sensitivity C-reactive protein (hs-CRP)in Helicobacter pylori-infected peptic ulcer patients and its association with bacterial CagA virulence factor. (19160050)
2009
19
Myocardial infarction, peptic ulcer and acetylsalicylic acid: of good and evil. (19816625)
2009
20
Weekend versus weekday admission and mortality from gastrointestinal hemorrhage caused by peptic ulcer disease. (18849015)
2009
21
Diverse characteristics of the CagA gene of Helicobacter pylori strains collected from patients from southern vietnam with gastric cancer and peptic ulcer. (19846630)
2009
22
Early history of dyspepsia and peptic ulcer in the United States. (19956114)
2009
23
Management of perforated peptic ulcer in patients at a teaching hospital. (18246235)
2008
24
Evaluation of the clinical significance of homB, a novel candidate marker of Helicobacter pylori strains associated with peptic ulcer disease. (18811585)
2008
25
Duration of survival after peptic ulcer perforation. (18172710)
2008
26
Evidence for the role of gastric mucosa at the secretion of soluble triggering receptor expressed on myeloid cells (strem-1) in peptic ulcer disease. (17729416)
2007
27
A comparative study on Helicobacter pylori infection in peptic ulcer disease patients with or without previous eradication therapy. (18265634)
2007
28
Peptic ulcer of the gastric tube after esophagectomy for cancer: clinical implications. (17958733)
2007
29
Effects of interleukin-10 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese subjects. (17716348)
2007
30
Distinct diversity of vacA, cagA, and cagE genes of Helicobacter pylori associated with peptic ulcer in Japan. (16081930)
2005
31
A case of post-partum borderline tuberculoid leprosy complicated by a median nerve abscess, peptic ulceration and rifampicin-induced haemolytic renal failure. (15282971)
2004
32
A simplified prognostic scoring system for peptic ulcer perforation in developing countries. (12696822)
2003
33
Factor V inhibitor after injection of human thrombin (tissucol) into a bleeding peptic ulcer. (12783357)
2003
34
Experience of peptic ulcer perforation over a decade in a teaching hospital of southern Bangladesh. (12971209)
2003
35
CagA status in dyspeptic patients with and without peptic ulcer disease in Turkey: association with histopathologic findings. (11422473)
2001
36
The effect of histamine H2 receptor blockers on reparative processes in the gastric mucosa of patients with gastric peptic ulcer]. (10222548)
1999
37
Infection with Helicobacter pylori expressing the cagA gene is not associated with an increased risk of developing peptic ulcer diseases in Korean patients. (9759946)
1998
38
How to achieve a near 100% cure rate for H. pylori infection in peptic ulcer patients. A personal viewpoint. (8771431)
1996
39
Risk of postoperative upper gastrointestinal tract hemorrhage in patients with active peptic ulcer disease undergoing nonulcer surgery. (8379806)
1993
40
Acanthamoeba infection of peptic ulcer. (8250632)
1993
41
Activity of glutathione-dependent enzymes and superoxide dismutase in peptic ulcer]. (1440967)
1992
42
Endoscopic stage classification of peptic ulcer and characterization of the healing process by proton pump inhibitors]. (1347333)
1992
43
Effect of continuous intravenous infusion of secretin preparation (secrepan) in patients with hemorrhage from chronic peptic ulcer and acute gastric mucosal lesion (AGML). (1884969)
1991
44
Somatostatin release by human gastric mucosa. Studies in peptic ulcer disease and pernicious anemia. (2902682)
1988
45
Relevance of duodenitis to non-ulcer dyspepsia and peptic ulceration. (6962536)
1982
46
Gastritis, duodenitis, and peptic ulcer disease: Fourth International Symposium. (6119338)
1981
47
Unusual comparative frequency of gastric carcinoma, pernicious anemia, and peptic ulcer in southwestern American Indians. (4753346)
1973
48
Esophageal stenosis caused by peptic esophagitis or ulceration. (13154601)
1954
49
Neurilemmoma of stomach wall with peptic ulcer. (14870091)
1951
50
Evaluation of clinical methods in gastro-intestinal disease. IV. Autopsy findings of liver disease (fatty infiltration, hepatic cirrhosis) observed in peptic ulcer cases. (14885142)
1951

Genetic Variations for Peptic Ulcer

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Expression for genes affiliated with Peptic Ulcer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Peptic Ulcer

Search GEO for disease gene expression data for Peptic Ulcer.

Pathways for genes affiliated with Peptic Ulcer

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53Reactome, 12EMD Millipore, 29KEGG, 37NCBI BioSystems Database
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Pathways related to Peptic Ulcer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4CYP2C19, PTGS1, PTGS2
210.4PTGS2, IL8, CD14
310.4PTGS1, PTGS2, ALB
410.4IL8, CXCL1, CD14
510.4IL8, CXCL1, CD14
6
Cytokine production by Th17 cells in CF (Mouse model)
10.4CD14, CXCL1, IL8
7
Hide members
10.4PTGS2, PTGS1, AKR1A1

Compounds for genes affiliated with Peptic Ulcer

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44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Peptic Ulcer according to GeneCards/GeneDecks:

(show top 50)    (show all 206)
idCompoundScoreTop Affiliating Genes
1pge24410.9PTGS2
2pepsinogen4410.9HRH2, CTSD, GAST, SCT
3Acetylsalicylic acid1110.8CYP2C19, ALB, PTGS2, PTGS1
4clarithromycin44 1111.8HRH2, S100A8, GAST, CYP2C19, IL8
5ranitidine44 28 11 2413.8GAST, HRH2, CYP2C19, AKR1A1, SCT
6amoxicillin44 49 1112.8CYP2C19, S100A8, GAST, HRH2
7pantoprazole44 49 11 2413.8GAST, ATP4A, CYP2C19, HRH2
8acetaminophen44 2 49 11 2414.8CYP2C19, HRH2
9omeprazole44 28 49 11 2414.8SCT, GAST, ATP4A, HDC, HRH2, CYP2C19
10diclofenac44 28 49 1113.8ALB, PTGS2, PTGS1, HRH2, CYP2C19
11Magnesium salicylate1110.8PTGS2, PTGS1, ALB
12cimetidine44 28 1112.8SCT, GAST, AKR1A1, CYP2C19, HRH2
13lansoprazole49 44 11 2413.8HRH2, CYP2C19, GAST, ATP4A
14antipyrine44 1111.8ALB, PTGS2, PTGS1, CYP2C19
15dexamethasone44 49 28 1113.8S100A8, MUC5AC, CD14, CYP2C19, CXCL1, PTGS2
16fenoprofen28 44 1112.8ALB, PTGS1, PTGS2
17celecoxib44 59 28 49 11 2415.8ALB, PTGS2, PTGS1, GAST, HRH2
18indomethacin44 59 28 1113.8SCT, AKR1A1, ALB, CDKN3, CYP2C19, PTGS1
19ethanol44 49 11 2413.8CTSD, SCT, AKR1A1, MUC5AC, CYP2C19, HRH2
20lactate4410.8IL8, PTGS1, ALB, CTSD, AKR1A1, HRH2
21bicarbonate4410.8HRH2, AKR1A1, SCT, ALB, GAST
22esomeprazole44 49 1112.7GAST, ATP4A, CYP2C19
23lumiracoxib44 28 1112.7CYP2C19, PTGS1, PTGS2
24aspartate4410.7AKR1A1, HDC, CTSD, SCT, CD14, ALB
25lafutidine4410.7HRH2, GAST, SCT
26serine4410.7AKR1A1, MUC5AC, PTGS1, SCT, S100A8, CDKN3
27rantes4410.7CXCL1, CD14, HDC, SCT, S100A8
28triptolide4410.7PTGS2, CD14, IL8, PTGS1
29oxygen44 2411.7CTSD, IL8, CYP2C19, AKR1A1, S100A8, PTGS1
30histamine44 28 2412.7GAST, AKR1A1, HDC, MUC5AC, CD14, CXCL1
31retinoic acid44 2411.7CTSD, CXCL1, S100A8, HRH2, CYP2C19, CD14
32nitric oxide44 11 2412.7MUC5AC, HRH2, PTGS1, IL8, CXCL1, CYP2C19
33cyclosporin a44 28 5912.7CD14, CYP2C19, CXCL1, IL8, CTSD, CDKN3
34tolmetin44 1111.7PTGS1, PTGS2, ALB
35cysteine4410.7IL8, CXCL1, CD14, MUC5AC, AKR1A1, ALB
36sulfasalazine44 28 49 1113.7PTGS1, IL8, CXCL1, PTGS2
37alanine4410.7CDKN3, CD14, HDC, ALB, AKR1A1, GAST
38bismuth44 2411.7GAST, ALB, HRH2
39glutamate4410.6HDC, SCT, AKR1A1, GAST
40etoricoxib44 28 1112.6CYP2C19, PTGS2, PTGS1
41vegf4410.6IL8, PTGS1, PTGS2, CD14, CTSD, GAST
42creatinine4410.6S100A8, CTSD, HRH2, GAST, CD14, ALB
43fosphenytoin44 1111.6ALB, CYP2C19, CDKN3
44valdecoxib44 28 11 2413.5PTGS2, PTGS1, CYP2C19
45adenylate4410.5CTSD, HRH2, CXCL1, CDKN3, AKR1A1, SCT
46diflunisal44 1111.5PTGS2, PTGS1, ALB
47rabeprazole44 49 11 2413.4CYP2C19, ATP4A, GAST
48herbimycin a44 5911.4PTGS1, PTGS2, CD14, CDKN3, IL8
49calcium44 49 11 2413.2ALB, SCT, S100A8, HRH2, CTSD, CXCL1
50pd 98,0594410.1SCT, MUC5AC, CD14, CXCL1, IL8, PTGS2

GO Terms for genes affiliated with Peptic Ulcer

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16Gene Ontology
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Cellular components related to Peptic Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.3CTSD, DEFA5, CD14, CXCL1, IL8, ALB
2extracellular regionGO:00557610.0ALB, S100A8, SCT, CTSD, GAST, DEFA5

Biological processes related to Peptic Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclooxygenase pathwayGO:01937110.4PTGS2, PTGS1
2inflammatory responseGO:00695410.3PTGS2, IL8, CXCL1, CD14, S100A8
3arachidonic acid metabolic processGO:01936910.1CYP2C19, PTGS1, PTGS2

Molecular functions related to Peptic Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prostaglandin-endoperoxide synthase activityGO:00466610.4PTGS2, PTGS1

Products for genes affiliated with Peptic Ulcer

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Sources for Peptic Ulcer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet