MCID: PPT005
MIFTS: 58

Peptic Ulcer Disease malady

Categories: Gastrointestinal diseases

Aliases & Classifications for Peptic Ulcer Disease

Aliases & Descriptions for Peptic Ulcer Disease:

Name: Peptic Ulcer Disease 12 29 14
Peptic Ulcer 52 41 42 69
Acute Peptic Ulcer Without Hemorrhage and Without Perforation 12
Acute Peptic Ulcer with Hemorrhage and Perforation 12
Acute Peptic Ulcer with Hemorrhage 12

Classifications:



External Ids:

Disease Ontology 12 DOID:750
ICD10 33 K27
ICD9CM 35 533
MeSH 42 D010437
NCIt 47 C3318
UMLS 69 C0030920

Summaries for Peptic Ulcer Disease

MedlinePlus : 41 a peptic ulcer is a sore in the lining of your stomach or your duodenum, the first part of your small intestine. a burning stomach pain is the most common symptom. the pain starts between meals or during the night briefly stops if you eat or take antacids lasts for minutes to hours comes and goes for several days or weeks peptic ulcers happen when the acids that help you digest food damage the walls of the stomach or duodenum. the most common cause is infection with a bacterium called helicobacter pylori. another cause is the long-term use of nonsteroidal anti-inflammatory medicines (nsaids) such as aspirin and ibuprofen. stress and spicy foods do not cause ulcers, but can make them worse. to see if you have an h. pylori infection, your doctor will test your blood, breath, or stool. your doctor also may look inside your stomach and duodenum by doing an endoscopy or x-ray. peptic ulcers will get worse if not treated. treatment may include medicines to reduce stomach acids or antibiotics to kill h. pylori. antacids and milk can't heal peptic ulcers. not smoking and avoiding alcohol can help. you may need surgery if your ulcers don't heal. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Peptic Ulcer Disease, also known as peptic ulcer, is related to intussusception and myocardial infarction, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Peptic Ulcer Disease is HRH2 (Histamine Receptor H2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-Like receptor Signaling Pathways. The drugs Aspirin and Pantoprazole have been mentioned in the context of this disorder. Affiliated tissues include small intestine, kidney and testes, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Wikipedia : 71 Peptic ulcer disease (PUD), is a break in the lining of the stomach, first part of the small intestine,... more...

Related Diseases for Peptic Ulcer Disease

Diseases related to Peptic Ulcer Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 227)
id Related Disease Score Top Affiliating Genes
1 intussusception 29.8 IL1B TNF
2 myocardial infarction 28.9 CYP2C19 IL10 IL1B PTGS1 PTGS2 TNF
3 peptic ulcer perforation 12.4
4 active peptic ulcer disease 12.2
5 dyspepsia 11.3
6 multiple endocrine neoplasia 1 10.9
7 chronic erosive gastritis 10.9
8 gastritis 10.4
9 congenital diaphragmatic hernia 10.3 ATP4A PTGS2
10 secondary syphilis 10.3 ATP4A GAST
11 brain edema 10.3 ATP4A GAST
12 primary non-gestational choriocarcinoma of ovary 10.2 CXCL8 PTGS2
13 vein disease 10.2 ATP4A GAST S100A8
14 oculomotor nerve paralysis 10.2 CXCL8 IL1B
15 common peroneal nerve lesion 10.2 CXCL8 IL1B
16 gastric cancer 10.2
17 bladder neck cancer 10.2 ATP4A CYP2C19 HRH2
18 scrotum squamous cell carcinoma 10.2 ATP4A CYP2C19
19 hidradenitis 10.2 CXCL8 IL1B PTGS2
20 tau syndrome 10.2 IL1B TNF
21 pleomorphic rhabdomyosarcoma 10.2 ATP4A HRH2
22 chondrodysplasia punctata, rhizomelic, type 1 10.2 CYP2C19 IL1B PTGS2
23 pyridoxal 5'-phosphate-dependent epilepsy 10.2 IL10 TNF
24 stocco dos santos syndrome 10.2 IL1B TNF
25 solitary plasmacytoma of chest wall 10.2 GAST PTGS2 S100A8
26 tubular renal disease-cardiomyopathy syndrome 10.2 IL10 TNF
27 spinal muscular atrophy with progressive myoclonic epilepsy 10.1 ATP4A GAST PTGS2 S100A8
28 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 10.1 IL1B TNF
29 gastroduodenal crohn's disease 10.1 ATP4A IL1B TNF
30 angioedema 10.1 HRH2 PTGS1 PTGS2
31 post-vaccinal encephalitis 10.1 GAST SCT
32 neovascular glaucoma 10.1 CXCL8 PTGS2 TNF
33 duodenitis 10.1
34 lagophthalmos 10.1 IL10 TNF
35 amyotrophic lateral sclerosis type 14 10.1 CXCL8 IL1B TNF
36 acquired thrombocytopenia 10.1 CXCL8 IL1B TNF
37 neuropathy 10.1 CXCL8 IL1B TNF
38 ovarian cystic teratoma 10.1 CXCL8 IL1B TNF
39 blepharochalasis 10.1 CXCL8 IL1B TNF
40 multiple vertebral anomalies unusual facies 10.1 IL10 TNF
41 nasopharyngitis 10.1 CXCL8 IL1B TNF
42 nutritional optic neuropathy 10.1 GAST GHRL
43 stenosis of lacrimal sac 10.1 CXCL8 IL1B TNF
44 childhood electroclinical syndrome 10.1 CXCL8 IL10 IL1B
45 baritosis 10.1 CXCL8 IL1B TNF
46 orthostatic proteinuria 10.1 CXCL8 IL1RN TNF
47 inflammatory bowel disease 20 10.1 CXCL8 IL10
48 spondylolysis 10.1 CXCL8 IL1B TNF
49 warthin tumor 10.1 IL1B IL1RN TNF
50 twin-to-twin transfusion syndrome 10.1 IL1B TNF

Comorbidity relations with Peptic Ulcer Disease via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Peptic Ulcer Disease:



Diseases related to Peptic Ulcer Disease

Symptoms & Phenotypes for Peptic Ulcer Disease

UMLS symptoms related to Peptic Ulcer Disease:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, signs and symptoms, digestive, gastrointestinal gas

MGI Mouse Phenotypes related to Peptic Ulcer Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.86 GAST GHRL HRH2 IL10 PTGS1 PTGS2
2 endocrine/exocrine gland MP:0005379 9.76 ATP4A GAST GHRL HRH2 IL10 PTGS1
3 homeostasis/metabolism MP:0005376 9.65 PTGS2 TNF ATP4A GAST GHRL HRH2
4 neoplasm MP:0002006 9.1 GAST IL10 IL1B PTGS1 PTGS2 TNF

Drugs & Therapeutics for Peptic Ulcer Disease

Drugs for Peptic Ulcer Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 297)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
2
Pantoprazole Approved Phase 4,Phase 3,Phase 2,Phase 1 102625-70-7 4679
3
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 73590-58-6 4594
4
Histamine Approved, Investigational Phase 4,Phase 3,Phase 1 75614-87-8, 51-45-6 774
5
Ticlopidine Approved Phase 4,Phase 3,Phase 2,Phase 1 55142-85-3 5472
6
Famotidine Approved Phase 4,Phase 3 76824-35-6 3325
7
Clarithromycin Approved Phase 4,Phase 3,Phase 2 81103-11-9 84029
8
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3 26787-78-0 33613 2171
9
Metronidazole Approved Phase 4,Phase 2,Phase 3 443-48-1 4173
10
Ecabet Approved, Investigational Phase 4 33159-27-2, 86408-72-2 65781
11
Lansoprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 103577-45-3 3883
12
Rabeprazole Approved, Investigational Phase 4,Phase 2,Phase 3 117976-89-3 5029
13
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 161796-78-7, 119141-88-7 4594 9579578
14
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Phase 3 616-91-1 12035
15
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
16
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
17
Erythromycin Approved, Vet_approved Phase 4 114-07-8 12560
18
Celecoxib Approved, Investigational Phase 4,Phase 3 169590-42-5 2662
19
Tetracycline Approved, Vet_approved Phase 4,Phase 3 60-54-8 5353990
20
Ranitidine Approved Phase 4,Phase 3,Phase 1 66357-59-3, 66357-35-5 3001055
21
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22204-53-1 1302 156391
22
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
23
Ofloxacin Approved Phase 4,Phase 3 82419-36-1 4583
24
Sulpiride Approved Phase 4 15676-16-1 5355
25
Menthol Approved Phase 4,Phase 3 2216-51-5 16666
26
Loxoprofen Approved Phase 4 68767-14-6, 80382-23-6 3965
27
Levofloxacin Approved, Investigational Phase 4,Phase 3 100986-85-4 149096
28
Furazolidone Approved, Vet_approved Phase 4 67-45-8 3435 5323714
29
Guaifenesin Approved, Vet_approved Phase 4,Phase 3 93-14-1 3516
30
Potassium Citrate Approved, Vet_approved Phase 4,Phase 3
31
Coal tar Approved Phase 4 8007-45-2
32 Trimebutine Approved Phase 4 39133-31-8
33
Clopidogrel Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 120202-66-6, 113665-84-2 60606
34
Ginseng Approved, Nutraceutical Phase 4 50647-08-0
35 Benzimidazole Experimental Phase 4 51-17-2
36
Maleic acid Experimental Phase 4,Phase 1 110-16-7 444266
37 Geranylgeranylacetone Phase 4,Phase 2,Phase 3
38
Dexlansoprazole Phase 4,Phase 3,Phase 2,Phase 1 138530-94-6, 103577-45-3 9578005
39
Histamine Phosphate Phase 4,Phase 3,Phase 1 51-74-1 65513
40
Proton pump inhibitors Phase 4,Phase 3,Phase 2,Phase 1
41 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
42
protease inhibitors Phase 4,Phase 3,Phase 2
43 N-monoacetylcystine Phase 4,Phase 2,Phase 3
44 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
45 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
46 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
47 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2
48 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2
49 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
50 Hemostatics Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 359)
id Name Status NCT ID Phase
1 Long-term Oral Esomeprazole for Prevention of Peptic Ulcer Rebleeding in High-risk Patients Unknown status NCT02456012 Phase 4
2 Oral vs Intravenous and Proton Pump Inhibitor (PPI)for Peptic Ulcer Bleeding (PUB) Unknown status NCT01123031 Phase 4
3 Compare Efficacy of Gastric Acid Suppression by Oral and Intravenous Administration of Esomeprazole in Patients With Peptic Ulcer Unknown status NCT00471029 Phase 4
4 Helicobacter Pylori Empiric Treatment in Ulcer Bleeding Unknown status NCT00687336 Phase 4
5 A Double Blind Study Comparing Two Doses of IV Esomeprazole After Successful Endoscopic Therapy Unknown status NCT01275937 Phase 4
6 Study Comparing Sequential and Concomitant Therapy for Helicobacter Pylori Eradication in Routine Clinical Practice Unknown status NCT01273441 Phase 4
7 Efficacy of Ecabet Sodium and Proton Pump Inhibitor Combination Therapy in the Treatment of Iatrogenic Ulcer After Endoscopic Submucosal Dissection Unknown status NCT01308177 Phase 4
8 Esomeprazole or Famotidine in the Management of Aspirin Related Non-Ulcer Dyspepsia Unknown status NCT00978159 Phase 4
9 14-day Quadruple Hybrid vs. Concomitant Therapies for Helicobacter Pylori Eradication Unknown status NCT01464060 Phase 4
10 Efficacy of Acetylcysteine-containing Triple Therapy in the First Line of Helicobacter Pylori Infection Unknown status NCT02249546 Phase 4
11 H. Pylori Eradication on Healing of Iatrogenic Gastric Ulcer by Endoscopic Mucosal Resection Unknown status NCT00926809 Phase 4
12 Concomitant Therapy of H. Pylori Unknown status NCT01922765 Phase 4
13 A Comparison of Two Therapeutic Strategies for the Treatment of Aspirin-associated Peptic Ulcers Completed NCT01353144 Phase 4
14 Fast-track Surgery for Perforated Peptic Ulcers Completed NCT01620671 Phase 4
15 The Therapeutic Role of Intravenous Albumin Administration for Peptic Ulcer Bleeding Patients With Hypoalbuminemia Completed NCT01822600 Phase 4
16 Importance of Cytokines in Peptic Ulcer Disease: Implications for Treatment Completed NCT00534443 Phase 4
17 Intravenous Proton Pump Inhibitor for Peptic Ulcer Bleeding Completed NCT00731601 Phase 4
18 Famotidine Compared With Pantoprazole to Prevent Recurrent Aspirin-Induced Peptic Ulcer/Erosion Completed NCT00843063 Phase 4
19 The Efficacy of Double Doses of Oral Esomeprazole in Preventing Rebleeding for Patients With Bleeding Peptic Ulcers Completed NCT01591083 Phase 4
20 Celebrex Low Dose ASA Study Examining the Incidence of Gastroduodenal Ulcers in a Healthy Population Completed NCT00137033 Phase 4
21 Effects of 2 Different Doses of Pantoprazole on Gastric pH and Recurrent Bleeding in Patients Who Bled From Peptic Ulcers Completed NCT00279123 Phase 4
22 Administration of High-Dose Intravenous Proton Pump Inhibitor for Upper Gastrointestinal Bleeding Prior to Endoscopy Completed NCT00164866 Phase 4
23 Argon Plasma Coagulation for Bleeding Peptic Ulcers Completed NCT02241044 Phase 4
24 Different Dose of Intravenous Omeprazole to Treat Bleeding Ulcer With Adherent Clot Completed NCT02536989 Phase 4
25 Clarithromycin Resistant Tailored Therapy Completed NCT01453036 Phase 4
26 The Dissemination of Consensus Recommendations on Upper Gastrointestinal Bleeding Completed NCT00840008 Phase 4
27 The Pilot Study on Tailored Eradication Therapy According to Clarithromycin Resistance in H.Pylori Patients Completed NCT02648659 Phase 4
28 Effect of Naproxen, Aspirin, Celecoxib, or Clopidogrel on the Healing of Stomach and Intestinal Ulcers Completed NCT00778193 Phase 4
29 Amoxicillin/Metronidazole Based Quadruple Therapy for Helicobacter Pylori Eradication Completed NCT02175901 Phase 4
30 Bismuth Improves the Efficacy of Levofloxacin-containing Triple Therapy for Helicobacter Pylori Treatment Completed NCT01667718 Phase 4
31 Empirical Rescue Therapies of Helicobacter Pylori Infection Completed NCT01668927 Phase 4
32 Comparison of Conventional Triple Therapy Versus Sequential Therapy for H. Pylori in Peptic Ulcer Disease: Prospective Randomized Trial Completed NCT01418300 Phase 4
33 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4
34 Efficiency Study of Clarithromycin and Bismuth-containing Quadruple Therapy to Treat H.Pylori Completed NCT01667575 Phase 4
35 Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Clarithromycin Quadruple Therapy Completed NCT02633930 Phase 4
36 Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Bismuth-containing Quadruple Therapy Completed NCT02296021 Phase 4
37 Relation of Metabolic Rate of Omeprazole and Eradication of Helicobacter Pylori Infection Completed NCT00854451 Phase 4
38 Study Of Celecoxib In Healthy Subjects Completed NCT00994461 Phase 4
39 Proton Pump Inhibitor Treatment Stop Completed NCT00120315 Phase 4
40 Prevention of Gastrointestinal Bleeding in Patients With Severe Ischemic Heart Disease Completed NCT00683111 Phase 4
41 A Trial of Standard vs Half Dose Rabeprazole, Clarithromycin, Metronidazole and Amoxicillin in the Treatment of Helicobacter Pylori Infection Completed NCT01219764 Phase 4
42 The Efficacy of Sequential Therapy as Second Line Therapy for Refractory Helicobacter Pylori Infection - A Pilot Study Completed NCT00885417 Phase 4
43 Treatment of Zollinger-Ellison Syndrome With Prevacid Completed NCT00204373 Phase 4
44 Efficacy of 10-day and 14-day Sequential Therapy Versus Triple Therapy on the Eradication of Helicobacter Pylori Completed NCT01042184 Phase 4
45 The Efficacy of Susceptibility Test -Driven Sequential Therapy as the Third Line Therapy for Refractory Helicobacter Pylori Infection Completed NCT01032655 Phase 4
46 Comparison of Sequential or Concomitant Therapy for Helicobacter Pylori Infection Completed NCT00656968 Phase 4
47 Comparison of the Efficacy for Stress Ulcer Prophylaxis Between the Patients Received Lansoprazole OD and Control Group Weaning From Mechanical Ventilator in Respiratory Care Center: a Randomized Control Trial Completed NCT00708149 Phase 4
48 Clinical Study on the Treatment of Hypertensive Intracerebral Hemorrhage With Panax Notoginseng Saponin Completed NCT02999048 Phase 4
49 Ulcer Prevention Study in Post Gastric Bypass Patients Completed NCT00557349 Phase 4
50 Evaluation of the Influence of Statins and Proton Pump Inhibitors on Clopidogrel Antiplatelet Effects Completed NCT00930670 Phase 4

Search NIH Clinical Center for Peptic Ulcer Disease

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: peptic ulcer

Genetic Tests for Peptic Ulcer Disease

Genetic tests related to Peptic Ulcer Disease:

id Genetic test Affiliating Genes
1 Peptic Ulcer 29

Anatomical Context for Peptic Ulcer Disease

MalaCards organs/tissues related to Peptic Ulcer Disease:

39
Small Intestine, Kidney, Testes, Liver, Neutrophil, Endothelial, Tongue

Publications for Peptic Ulcer Disease

Articles related to Peptic Ulcer Disease:

(show top 50) (show all 307)
id Title Authors Year
1
Identification of Helicobacter pylori and the evolution of an efficacious childhood vaccine to protect against gastritis and peptic ulcer disease. ( 27701380 )
2017
2
Efficacy of Zinc Sulfate in Peptic Ulcer Disease: A Randomized Double-Blind Clinical Trial Study. ( 27656478 )
2016
3
Association between ulcer site and outcome in complicated peptic ulcer disease: a Danish nationwide cohort study. ( 27248208 )
2016
4
Seasonal Variations and Trends in Hospitalization for Peptic Ulcer Disease in the United States: A 12-Year Analysis of the Nationwide Inpatient Sample. ( 27909642 )
2016
5
Increased Risk of Osteoporosis in Patients With Peptic Ulcer Disease: A Nationwide Population-Based Study. ( 27100415 )
2016
6
Proton pump inhibitors, purple gastric juice and peptic ulcer disease. ( 27795292 )
2016
7
Eradication therapy for peptic ulcer disease in Helicobacter pylori-positive people. ( 27092708 )
2016
8
Peptic ulcer disease in living liver donors: A longitudinal population-based study. ( 27063452 )
2016
9
Evidence-based clinical practice guidelines for peptic ulcer disease 2015. ( 26879862 )
2016
10
The Association Between Peptic Ulcer Disease and Ischemic Stroke: A Population-Based Longitudinal Study. ( 27258514 )
2016
11
Association of Dementia and Peptic Ulcer Disease: A Nationwide Population-Based Study. ( 26802077 )
2016
12
Management of NSAID-associated peptic ulcer disease. ( 26775657 )
2016
13
Risk Factors for the Presence of Symptoms in Peptic Ulcer Disease. ( 28008163 )
2016
14
Molecular hydrogen in human breath: a new strategy for selectively diagnosing peptic ulcer disease, non-ulcerous dyspepsia and Helicobacter pylori infection. ( 27448107 )
2016
15
Efficacy of Levofloxacin-Based Third-Line Therapy for the Eradication of Helicobacter pylori in Peptic Ulcer Disease. ( 27609487 )
2016
16
Distinctive aspects of peptic ulcer disease, Dieulafoy's lesion, and Mallory-Weiss syndrome in patients with advanced alcoholic liver disease or cirrhosis. ( 26755890 )
2016
17
Probiotics in Helicobacter pylori-induced peptic ulcer disease. ( 27048901 )
2016
18
Peptic Ulcer Disease and Helicobacter pylori Infection in Different Siberian Ethnicities. ( 27265879 )
2016
19
The Development of Diabetes after Subtotal Gastrectomy with Billroth II Anastomosis for Peptic Ulcer Disease. ( 27893867 )
2016
20
Validity of peptic ulcer disease and upper gastrointestinal bleeding diagnoses in administrative databases: a systematic review protocol. ( 27633635 )
2016
21
Antroduodenectomy with Gastroduodenal Anastomosis: Salvage Emergency Surgery for Complicated Peptic Ulcer Disease-Results of a Double Institution Study of 35 Patients. ( 26643299 )
2016
22
Letter: risk factor and mortality of peptic ulcer disease. ( 27412998 )
2016
23
How host regulation of Helicobacter pylori-induced gastritis protects against peptic ulcer disease and gastric cancer. ( 27469367 )
2016
24
Subtotal Gastrectomy With Billroth II Anastomosis Is Associated With a Low Risk of Ischemic Stroke in Peptic Ulcer Disease Patients: A Nationwide Population-Based Study. ( 27100454 )
2016
25
A 10-Year Review of Surgical Management of Complicated Peptic Ulcer Disease From a Single Center: Is Laparoscopic Approach the Future? ( 27661205 )
2016
26
Women Who Sleep More Have Reduced Risk of Peptic Ulcer Disease; Korean National Health and Nutrition Examination Survey (2008-2009). ( 27830741 )
2016
27
Letter: risk factor and mortality of peptic ulcer disease - authors' reply. ( 27413000 )
2016
28
Prevalence of Helicobacter Pylori-Negative, Non-Steroidal Anti-Inflammatory Drug Related Peptic Ulcer Disease in Patients Referred to Afzalipour Hospital. ( 26609353 )
2015
29
Diagnosis and Treatment of Peptic Ulcer Disease and H. pylori Infection. ( 25955624 )
2015
30
Genome Sequencing of 10 Helicobacter pylori Pediatric Strains from Patients with Nonulcer Dyspepsia and Peptic Ulcer Disease. ( 25657274 )
2015
31
Effect of dementia on outcomes of elderly patients with hemorrhagic peptic ulcer disease based on a national administrative database. ( 25708828 )
2015
32
Impact of Creatinine Clearance on Helicobacter Pylori Eradication Rate in Patients With Peptic Ulcer Disease. ( 26552348 )
2015
33
Upper gastrointestinal bleeding due to peptic ulcer disease is not associated with air pollution: a case-crossover study. ( 26467538 )
2015
34
Treating Gastritis, Peptic Ulcer Disease, and Dyspepsia in the Emergency Department: The Feasibility and Patient-Reported Outcomes of Testing and Treating for Helicobacter pylori Infection. ( 25805114 )
2015
35
Decreased stress resilience in young men significantly increases the risk of subsequent peptic ulcer disease - a prospective study of 233A 093 men in Sweden. ( 25809417 )
2015
36
Prescription Patterns of Traditional Chinese Medicine for Peptic Ulcer Disease in Taiwan: A Nationwide Population-based Study. ( 26549268 )
2015
37
Depression and the Risk of Peptic Ulcer Disease: A Nationwide Population-Based Study. ( 26705225 )
2015
38
Comparison of 10-day sequential therapy with 7-day standard triple therapy for Helicobacter pylori eradication in inactive peptic ulcer disease and the efficiency of sequential therapy in inactive peptic ulcer disease and non-ulcer dyspepsia. ( 26635102 )
2015
39
Risk factors influencing morbidity and mortality in perforated peptic ulcer disease. ( 25931940 )
2015
40
The relationship between the Five-Factor Model personality traits and peptic ulcer disease in a large population-based adult sample. ( 26437682 )
2015
41
Balloon dilatation in patients with gastric outlet obstruction related to peptic ulcer disease. ( 26440958 )
2015
42
Helicobacter pylori virulence genes and host genetic polymorphisms as risk factors for peptic ulcer disease. ( 26470920 )
2015
43
Surgery for Peptic Ulcer Disease in sub-Saharan Africa: Systematic Review of Published Data. ( 26573850 )
2015
44
Does Helicobacter pylori Eradication Reduce the Risk of Open Angle Glaucoma in Patients With Peptic Ulcer Disease? ( 26426633 )
2015
45
Epstein-Barr virus association with peptic ulcer disease. ( 26199856 )
2015
46
Is There Any Difference in the Eradication Rate of Helicobacter pylori Infection According to the Endoscopic Stage of Peptic Ulcer Disease? ( 25752487 )
2015
47
60-year-old man with chronic diarrhea and peptic ulcer disease. ( 25572206 )
2015
48
Duodenal perforation following esophagogastroduodenoscopy (EGD) with cautery and epinephrine injection for peptic ulcer disease: An interesting case of nonoperative management in the medical intensive care unit (MICU). ( 25837967 )
2015
49
Peptic ulcer disease in endogenous hypercortisolism: myth or reality? ( 25896553 )
2015
50
Peptic Ulcer Disease in Healthcare Workers: A Nationwide Population-Based Cohort Study. ( 26301861 )
2015

Variations for Peptic Ulcer Disease

Expression for Peptic Ulcer Disease

Search GEO for disease gene expression data for Peptic Ulcer Disease.

Pathways for Peptic Ulcer Disease

Pathways related to Peptic Ulcer Disease according to GeneCards Suite gene sharing:

(show all 37)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.26 CXCL8 IL10 IL1B IL1RN PTGS2 TNF
2
Show member pathways
12.89 CXCL8 IL1B IL1RN PTGS2 TNF
3 12.29 IL10 IL1B IL1RN PTGS1 PTGS2 TNF
4
Show member pathways
12.24 IL1B PTGS1 PTGS2 TNF
5
Show member pathways
12.21 CXCL8 IL1B PTGS2 S100A8 TNF
6
Show member pathways
12.17 CXCL8 IL1B PTGS2 TNF
7
Show member pathways
12.16 IL10 IL1B PTGS2 TNF
8
Show member pathways
12.06 CXCL8 IL10 IL1B TNF
9 12.01 CXCL8 IL10 IL1B IL1RN TNF
10
Show member pathways
11.91 CYP2C19 PTGS1 PTGS2
11 11.9 CXCL8 IL1B PTGS2 TNF
12 11.89 CYP2C19 PTGS1 PTGS2
13 11.86 IL1B PTGS2 TNF
14
Show member pathways
11.85 IL10 IL1B TNF
15 11.81 CXCL8 IL1B TNF
16 11.79 CXCL8 IL10 IL1B TNF
17 11.77 CXCL8 IL1B TNF
18 11.77 CXCL8 IL1B PTGS2 TNF
19 11.71 IL10 IL1B TNF
20 11.71 CXCL8 IL10 IL1B PTGS2 TNF
21
Show member pathways
11.68 CXCL8 PTGS2 TNF
22 11.68 IL10 IL1B TNF
23 11.64 CXCL8 IL10 IL1B TNF
24 11.59 CXCL8 IL1B TNF
25
Show member pathways
11.53 CXCL8 IL1B PTGS2 TNF
26 11.51 CXCL8 IL1B TNF
27 11.36 CXCL8 IL10 IL1B TNF
28 11.29 IL10 IL1B TNF
29 11.28 IL10 IL1B TNF
30 11.19 IL10 IL1B TNF
31 11.12 CXCL8 IL10 IL1B TNF
32 10.87 IL1B TNF
33 10.83 PTGS1 PTGS2
34 10.79 CXCL8 IL10 IL1B IL1RN PTGS2 TNF
35 10.54 CXCL8 PTGS1 PTGS2 TNF
36 10.46 GAST SCT
37 10.03 ATP4A GAST HRH2

GO Terms for Peptic Ulcer Disease

Cellular components related to Peptic Ulcer Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CXCL8 GAST GHRL IL10 IL1B IL1RN
2 organelle membrane GO:0031090 9.33 CYP2C19 PTGS1 PTGS2
3 extracellular space GO:0005615 9.32 ATP4A CXCL8 GAST GHRL IL10 IL1B

Biological processes related to Peptic Ulcer Disease according to GeneCards Suite gene sharing:

(show all 34)
id Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.87 GHRL PTGS1 PTGS2 TNF
2 immune response GO:0006955 9.85 CXCL8 HRH2 IL10 IL1B IL1RN TNF
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.83 IL1B S100A8 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.83 CXCL8 IL10 TNF
5 response to lipopolysaccharide GO:0032496 9.81 IL10 IL1B PTGS2 S100A8
6 activation of MAPK activity GO:0000187 9.8 GHRL IL1B TNF
7 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.79 IL10 IL1B TNF
8 response to organic substance GO:0010033 9.78 IL10 PTGS2 TNF
9 neutrophil chemotaxis GO:0030593 9.72 CXCL8 IL1B S100A8
10 prostaglandin metabolic process GO:0006693 9.66 PTGS1 PTGS2
11 negative regulation of lipid catabolic process GO:0050995 9.65 IL1B TNF
12 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.65 IL10 TNF
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.65 IL1B PTGS2 TNF
14 negative regulation of growth of symbiont in host GO:0044130 9.64 IL10 TNF
15 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.64 IL1B TNF
16 prostaglandin biosynthetic process GO:0001516 9.63 PTGS1 PTGS2
17 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.62 IL1B TNF
18 response to molecule of bacterial origin GO:0002237 9.61 CXCL8 IL10
19 cyclooxygenase pathway GO:0019371 9.6 PTGS1 PTGS2
20 positive regulation of chemokine biosynthetic process GO:0045080 9.59 IL1B TNF
21 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.58 IL10 IL1RN
22 endothelial cell apoptotic process GO:0072577 9.58 IL10 TNF
23 positive regulation of NF-kappaB import into nucleus GO:0042346 9.58 IL1B PTGS2 TNF
24 regulation of establishment of endothelial barrier GO:1903140 9.56 IL1B TNF
25 response to glucocorticoid GO:0051384 9.56 IL10 IL1RN PTGS2 TNF
26 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.54 GHRL IL10
27 negative regulation of cytokine secretion involved in immune response GO:0002740 9.52 IL10 TNF
28 embryonic digestive tract development GO:0048566 9.5 CXCL8 SCT TNF
29 sequestering of triglyceride GO:0030730 9.49 IL1B TNF
30 receptor biosynthetic process GO:0032800 9.46 IL10 TNF
31 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 IL1B TNF
32 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.33 IL10 IL1B TNF
33 inflammatory response GO:0006954 9.23 CXCL8 IL10 IL1B IL1RN PTGS1 PTGS2
34 positive regulation of fever generation GO:0031622 9.13 IL1B PTGS2 TNF

Molecular functions related to Peptic Ulcer Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.5 CYP2C19 PTGS1 PTGS2
2 hormone activity GO:0005179 9.33 GAST GHRL SCT
3 interleukin-1 receptor binding GO:0005149 9.26 IL1B IL1RN
4 cytokine activity GO:0005125 9.02 CXCL8 IL10 IL1B IL1RN TNF
5 prostaglandin-endoperoxide synthase activity GO:0004666 8.96 PTGS1 PTGS2

Sources for Peptic Ulcer Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
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36 IUPHAR
37 KEGG
38 LifeMap
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44 MGI
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48 NDF-RT
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54 OMIM
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59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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