MCID: PPT005
MIFTS: 45

Peptic Ulcer Disease malady

Summaries for Peptic Ulcer Disease

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MedlinePlus:32 A peptic ulcer is a sore in the lining of your stomach or your duodenum, the first part of your small intestine. a burning stomach pain is the most common symptom. the pain starts between meals or during the night briefly stops if you eat or take antacids lasts for minutes to hours comes and goes for several days or weeks peptic ulcers happen when the acids that help you digest food damage the walls of the stomach or duodenum. the most common cause is infection with a bacterium called helicobacter pylori. another cause is the long-term use of nonsteroidal anti-inflammatory medicines (nsaids) such as aspirin and ibuprofen. stress and spicy foods do not cause ulcers, but can make them worse. to see if you have an h. pylori infection, your doctor will test your blood, breath, or stool. your doctor also may look inside your stomach and duodenum by doing an endoscopy or x-ray. peptic ulcers will get worse if not treated. treatment may include medicines to reduce stomach acids or antibiotics to kill h. pylori. antacids and milk can't heal peptic ulcers. not smoking and avoiding alcohol can help. you may need surgery if your ulcers don't heal. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Peptic Ulcer Disease, also known as peptic ulcer, is related to gastritis and dyspepsia. An important gene associated with Peptic Ulcer Disease is HRH2 (histamine receptor H2), and among its related pathways is Defensins. The drugs propantheline and propantheline bromide and the compounds pirenzepine and famotidine have been mentioned in the context of this disorder. Affiliated tissues include small intestine, kidney and testes, and related mouse phenotype digestive/alimentary.

Wikipedia:63 Peptic ulcer disease (PUD), also known as a peptic ulcer or stomach ulcer, is a break in the lining of... more...

Aliases & Classifications for Peptic Ulcer Disease

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Peptic Ulcer Disease, Aliases & Descriptions:

Name: Peptic Ulcer Disease 9
Peptic Ulcer 11 43 32 60
Acute Peptic Ulcer with Hemorrhage 9 60
 
Acute Peptic Ulcer Without Hemorrhage and Without Perforation 9
Acute Peptic Ulcer with Hemorrhage and Perforation 9


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Disease Ontology9 DOID:750
ICD9CM27 533
NCIt38 C3318
MeSH33 D010437

Related Diseases for Peptic Ulcer Disease

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Diseases related to Peptic Ulcer Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 143)
idRelated DiseaseScoreTop Affiliating Genes
1gastritis31.3GHRL, DEFB4A
2dyspepsia31.2GHRL, HRH2
3gastric adenocarcinoma30.5DEFB4A, HRH2
4gastric ulcer30.4HRH2, GHRL
5periodontitis30.2DEFB1, DEFB4A
6periodontal disease30.2DEFB1, DEFB4A
7duodenal ulcer30.0DEFB1, HRH2, DEFB4A
8colitis29.8DEFB4A, IL12B, DEFB1
9ulcerative colitis29.7DEFB1, IL12B, DEFB4A
10inflammatory bowel disease29.7DEFB1, IL12B, DEFB4A
11asthma29.2DEFB1, HRH2, IL12B, DEFB4A, GHRL
12peptic ulcer perforation11.0
13active peptic ulcer disease10.6
14duodenitis10.6
15gastric outlet obstruction10.5
16peptic esophagitis10.5
17gastroduodenitis10.4
18adenocarcinoma10.4
19atrophic gastritis10.4
20hiatus hernia10.4
21liver cirrhosis10.4
22duodenogastric reflux10.4
23zollinger-ellison syndrome10.4
24pancreatitis10.4
25oral candidiasis10.3DEFB4A
26barrett esophagus/esophageal adenocarcinoma10.3
27islet cell tumor10.3
28meckel's diverticulum10.3
29dumping syndrome10.3
30neurilemmoma10.3
31candidiasis10.3DEFB4A
32gastroesophageal reflux10.3
33hepatitis10.3
34portal hypertension10.3
35herpes zoster10.3
36kidney disease10.3
37atherosclerosis10.2
38liver disease10.2
39gastrinoma10.2
40superior mesenteric artery syndrome10.2
41cystic teratoma10.2
42hyperparathyroidism10.2
43gastrocutaneous syndrome10.2
44teratoma10.2
45glucose intolerance10.1HRH2, GHRL
46hepatitis c virus10.1
47pancreatic cancer10.1
48myocardial infarction10.1
49h. pylori infection10.1
50acute myocardial infarction10.1

Graphical network of the top 20 diseases related to Peptic Ulcer Disease:



Diseases related to peptic ulcer disease

Symptoms for Peptic Ulcer Disease

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Drugs & Therapeutics for Peptic Ulcer Disease

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Drug clinical trials:

Search ClinicalTrials for Peptic Ulcer Disease

Search NIH Clinical Center for Peptic Ulcer Disease

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Peptic Ulcer Disease

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Anatomical Context for Peptic Ulcer Disease

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MalaCards organs/tissues related to Peptic Ulcer Disease:

31
Small intestine, Kidney, Testes, Liver, Heart, Colon, Myeloid, T cells, Endothelial, Tongue, Neutrophil

Animal Models for Peptic Ulcer Disease or affiliated genes

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MGI Mouse Phenotypes related to Peptic Ulcer Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.7HRH2, GHRL, IL12B

Publications for Peptic Ulcer Disease

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Articles related to Peptic Ulcer Disease:

(show top 50)    (show all 262)
idTitleAuthorsYear
1
Decreased stress resilience in young men significantly increases the risk of subsequent peptic ulcer disease - a prospective study of 233A 093 men in Sweden. (25809417)
2015
2
Genome Sequencing of 10 Helicobacter pylori Pediatric Strains from Patients with Nonulcer Dyspepsia and Peptic Ulcer Disease. (25657274)
2015
3
Effect of dementia on outcomes of elderly patients with hemorrhagic peptic ulcer disease based on a national administrative database. (25708828)
2015
4
Is There Any Difference in the Eradication Rate of Helicobacter pylori Infection According to the Endoscopic Stage of Peptic Ulcer Disease? (25752487)
2015
5
Effect of licorice versus bismuth on eradication of Helicobacter pylori in patients with peptic ulcer disease. (25276073)
2014
6
CagA and VacA genotypes in peptic ulcer disease and non-ulcer dyspepsia: a case-control study. (25664305)
2014
7
Peptic ulcer disease in liver cirrhosis and chronic hepatitis: impact of portal hypertension. (24902119)
2014
8
Association between Helicobacter pylori genotypes and severity of chronic gastritis, peptic ulcer disease and gastric mucosal interleukin-8 levels: Evidence from a study in the Middle East. (25279005)
2014
9
Fluoxetine inhibition of CYP3A4 potentiating adrenal suppression and peptic ulcer disease from intra-articular triamcinolone injections. (23565802)
2013
10
CYP2C19*17 gain-of-function polymorphism is associated with peptic ulcer disease. (23267857)
2013
11
Helicobacter pylori heterogeneity in patients with gastritis and peptic ulcer disease. (23523597)
2013
12
Alteration of the tongue manifestation reflects clinical outcomes of peptic ulcer disease. (23153037)
2012
13
Eradication of Helicobacter pylori infection reduces the incidence of peptic ulcer disease in patients using nonsteroidal anti-inflammatory drugs: a meta-analysis. (22759329)
2012
14
Gastrojejunal fistula caused by peptic ulcer disease. (22925294)
2012
15
Proinflammatory cytokines and thrombomodulin in patients with peptic ulcer disease and gastric cancer, infected with Helicobacter pylori. (21393888)
2011
16
Serum sTREM-1 as a surrogate marker of treatment outcome in patients with peptic ulcer disease. (21633832)
2011
17
Comparison between laparoscopic and open repair of perforated peptic ulcer disease in the elderly. (21679660)
2011
18
Efficacy of Helicobacter pylori eradication therapy in cirrhotic patients with peptic ulcer disease. (21870725)
2011
19
Systematic review of peptic ulcer disease incidence rates: do studies without validation provide reliable estimates? (21626606)
2011
20
An unusual complication of peptic ulcer disease: double pylorus. (21979403)
2011
21
Historical impact to drive research in peptic ulcer disease. (22095008)
2011
22
Complicated peptic ulcer disease in three patients with familial dysautonomia. (20930641)
2011
23
Association between acute pancreatitis and peptic ulcer disease. (21448359)
2011
24
Acute upper bleeding due to an unusual complication of peptic ulcer disease--double pylorus. (20617870)
2010
25
Peptic ulcer disease in India--a 16 year trend analysis. (21568140)
2010
26
Optimal management of peptic ulcer disease in the elderly. (20583849)
2010
27
Preface: peptic ulcer disease. (19446253)
2009
28
Early Helicobacter pylori eradication decreases risk of gastric cancer in patients with peptic ulcer disease. (19664631)
2009
29
Systematic review: the global incidence and prevalence of peptic ulcer disease. (19220208)
2009
30
A nationwide population-based cohort study shows reduced hospitalization for peptic ulcer disease associated with H pylori eradication and proton pump inhibitor use. (19264578)
2009
31
Antiplatelet therapy, Helicobacter pylori infection and complicated peptic ulcer disease in diabetes: the Fremantle Diabetes Study. (19125763)
2009
32
Time, change and peptic ulcer disease in Rotherham, UK. (18407812)
2008
33
Helicobacter pylori infection and peptic ulcer disease in Uzbekistan. (18665941)
2008
34
Has peptic ulcer disease changed during the past ten years in Korea? A prospective multi-center study. (17932759)
2008
35
Double pylorus: an unusual complication of peptic ulcer disease (with video). (18928930)
2008
36
Association between promoter polymorphisms of nuclear factor-erythroid 2-related factor 2 gene and peptic ulcer diseases. (17982693)
2007
37
Gastric epithelial anti-microbial peptides--histological correlation and influence of anatomical site and peptic ulcer disease. (15702860)
2005
38
Risk of stomach cancer in patients with peptic ulcer disease. (10658066)
2000
39
Infection with Helicobacter pylori expressing the cagA gene is not associated with an increased risk of developing peptic ulcer diseases in Korean patients. (9759946)
1998
40
Severe, recurrent peptic ulcer disease: a case of the Zollinger-Ellison syndrome. (7674667)
1995
41
The therapeutic strategy for peptic ulcer disease. (7881012)
1994
42
Benefits from elimination of Helicobacter pylori infection include major reduction in the incidence of peptic ulcer disease, gastric cancer, and primary gastric lymphoma. (7845945)
1994
43
Active chronic peptic ulcer disease complicated by gastric outlet obstruction in pregnancy. (8498952)
1993
44
Long-term omeprazole therapy in peptic ulcer disease: gastrin, endocrine cell growth, and gastritis. (8482449)
1993
45
Roxatidine acetate. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic potential in peptic ulcer disease and related disorders. (1717223)
1991
46
Pathogenesis and therapy of peptic ulcer disease. (1978840)
1990
47
Campylobacter pylori and duodenogastric reflux in peptic ulcer disease and gastritis. (2891956)
1988
48
Gastroduodenitis. A broader concept of peptic ulcer disease. (7418590)
1980
49
Case conference from Cornell. Case 6: depression and hypochondriasis in a patient with peptic ulcer disease. (523576)
1979
50
Comparison of basal gastric acid and pepsin output in controls vs. active peptic ulcer disease (PUD). (358827)
1978

Variations for Peptic Ulcer Disease

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Expression for genes affiliated with Peptic Ulcer Disease

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Search GEO for disease gene expression data for Peptic Ulcer Disease.

Pathways for genes affiliated with Peptic Ulcer Disease

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Pathways related to Peptic Ulcer Disease according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3DEFB1, DEFB4A

Compounds for genes affiliated with Peptic Ulcer Disease

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Compounds related to Peptic Ulcer Disease according to GeneCards Suite gene sharing:

(show all 22)
idCompoundScoreTop Affiliating Genes
1pirenzepine43 28 1211.8HRH2, GHRL
2famotidine43 2 24 1212.8HRH2, GHRL
3atropine43 28 1211.8GHRL, HRH2
4opiate439.7HRH2, GHRL
5acetaminophen43 2 49 24 1213.7HRH2, GHRL
6hbd2439.7DEFB4A, DEFB1
7urea43 24 1211.6HRH2, GHRL
85-hydroxytryptamine439.6GHRL, HRH2
9prostaglandin439.5HRH2, GHRL
10epinephrine43 24 1211.4GHRL, HRH2
11lipoteichoic acid439.3DEFB4A, IL12B
12peptidoglycan43 2810.3IL12B, DEFB4A
13histidine439.2HRH2, GHRL
14histamine43 28 2411.2HRH2, GHRL, DEFB4A
15nacl439.2GHRL, DEFB1, DEFB4A
16sb 20358043 5910.0IL12B, DEFB4A
17dexamethasone43 49 28 1212.0DEFB4A, DEFB1, GHRL
18retinoic acid43 249.9DEFB4A, DEFB1, HRH2
19nitric oxide43 24 1210.9HRH2, GHRL, IL12B
20rantes438.8IL12B, DEFB1, DEFB4A
21endotoxin438.4HRH2, GHRL, IL12B, DEFB4A
22lipid438.4DEFB4A, IL12B, GHRL, HRH2

GO Terms for genes affiliated with Peptic Ulcer Disease

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Cellular components related to Peptic Ulcer Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00057969.0DEFB1, DEFB4A
2extracellular regionGO:00055768.8GHRL, DEFB1, DEFB4A

Biological processes related to Peptic Ulcer Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00069359.3DEFB4A, DEFB1
2defense response to bacteriumGO:00427429.0DEFB1, DEFB4A
3G-protein coupled receptor signaling pathwayGO:00071868.8GHRL, DEFB4A, DEFB1
4immune responseGO:00069558.8HRH2, DEFB1, DEFB4A

Products for genes affiliated with Peptic Ulcer Disease

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Sources for Peptic Ulcer Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet