MCID: PPT002
MIFTS: 36

Peptic Ulcer Perforation malady

Categories: Gastrointestinal diseases

Aliases & Classifications for Peptic Ulcer Perforation

Aliases & Descriptions for Peptic Ulcer Perforation:

Name: Peptic Ulcer Perforation 12 42 14 69
Perforated Peptic Ulcer 12 52
Unspecified Peptic Ulcer with Perforation 12
Acute Peptic Ulcer with Perforation 12
Peptic Ulcer with Perforation 12

Classifications:



External Ids:

Disease Ontology 12 DOID:752
MeSH 42 D010439
UMLS 69 C0030925

Summaries for Peptic Ulcer Perforation

MalaCards based summary : Peptic Ulcer Perforation, also known as perforated peptic ulcer, is related to peptic ulcer disease and vascular disease. An important gene associated with Peptic Ulcer Perforation is ATP4A (ATPase H+/K+ Transporting Alpha Subunit), and among its related pathways/superpathways are L1CAM interactions and Salivary secretion. The drugs Aspirin and Heparin have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, and related phenotypes are Decreased caspase 3/7 activity and digestive/alimentary

Related Diseases for Peptic Ulcer Perforation

Diseases related to Peptic Ulcer Perforation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
id Related Disease Score Top Affiliating Genes
1 peptic ulcer disease 11.5
2 vascular disease 10.3 ALB ATP4A
3 arrhythmogenic right ventricular dysplasia 4 10.3 AMELX AMELY
4 pleomorphic rhabdomyosarcoma 10.3 ALB ATP4A HRH2
5 retinitis pigmentosa 59 10.3 AMELX AMELY
6 ocular cancer 10.2 AMELX AMELY
7 small intestinal l-cell glucagon-like peptide producing tumor 10.2 ATP4A HRH2 PTGS2
8 fetal hemoglobin quantitative trait locus 3 10.2 AMELX AMELY
9 inhalation anthrax 10.2 ALB ATP4A CRP
10 shoulder impingement syndrome 10.2 ALB CRP
11 functional diarrhea 10.2 ATP12A ATP4A
12 schizotypal personality disorder 10.2 ALB CRP HRH2
13 intracranial hypertension 10.2 ATP12A ATP4A
14 staphyloenterotoxemia 10.2 ATP12A ATP4A
15 colloid adenoma 10.2 ALB CD4
16 microphthalmia, syndromic 12 10.2 ATP12A ATP4A
17 ceruminoma 10.2 ATP12A ATP4A
18 amyotrophic lateral sclerosis type 10 10.2 ATP12A ATP4A
19 female breast upper-inner quadrant cancer 10.2 AMELX AMELY CRP
20 nephrocalcinosis 10.2 ALB CD4
21 adult extraosseous chondrosarcoma 10.2 ATP12A ATP4A HRH2
22 abnormal pupillary function 10.2 ATP12A ATP4A
23 bladder neck cancer 10.2 ATP12A ATP4A HRH2
24 cushing's syndrome 10.2 ATP4A PTGS2
25 heterophyiasis 10.2 CD4 CRP
26 porencephaly, cerebellar hypoplasia, and internal malformations 10.2 ALB ATP12A ATP4A
27 intravascular fasciitis 10.1 ATP12A ATP4A ITGA2
28 synostosis 10.1 ATP12A ATP4A CRP
29 congenital diaphragmatic hernia 10.1 ATP12A ATP4A PTGS2
30 mesenteric vascular occlusion 10.1 ATP12A ATP4A CRP
31 autonomic peripheral neuropathy 10.1 ALB AMELX CD4
32 scrotum squamous cell carcinoma 10.1 ATP4A CD4
33 acquired hemangioma 10.1 ATP12A ATP4A PTGS2
34 inguinal hernia 10.1 CD4 ITGA2
35 generalized dystonia 10.1 ALB CD4 CRP
36 basal cell carcinoma 10.1 AMELX AMELY
37 schneiderian carcinoma 10.1 ALB GAST
38 foodborne botulism 10.1 ALB CD4 CRP
39 acute chest syndrome 10.1 ALB CD4 CRP
40 hypertrophic elongation of cervix 10.1 CD4 CRP EZR
41 bone angioendothelial sarcoma 10.0 CD4 CRP PTGS2
42 scleral staphyloma 10.0 ATP12A ATP4A HRH2 PTGS2
43 mesothelioma, somatic 10.0 ATP12A ATP4A S100A8
44 villonodular synovitis 10.0 CD4 CRP
45 lymphocytic gastritis 10.0 ATP12A ATP4A CD4
46 intramuscular hemangioma 10.0 AMELX AMELY
47 membranoproliferative glomerulonephritis 10.0 ALB CD4 CRP
48 nasal cavity cancer 10.0 GAST HRH2 PTGS2
49 hyperornithinemia-hyperammonemia-homocitrullinemia syndrome 10.0 GAST HRH2 PTGS2
50 vein disease 10.0 ATP4A GAST S100A8

Graphical network of the top 20 diseases related to Peptic Ulcer Perforation:



Diseases related to Peptic Ulcer Perforation

Symptoms & Phenotypes for Peptic Ulcer Perforation

GenomeRNAi Phenotypes related to Peptic Ulcer Perforation according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased caspase 3/7 activity GR00318-A 8.8 CD4 GAST HRH2

MGI Mouse Phenotypes related to Peptic Ulcer Perforation:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.23 ALB ATP12A ATP4A CD4 EZR GAST

Drugs & Therapeutics for Peptic Ulcer Perforation

Drugs for Peptic Ulcer Perforation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 3 50-78-2 2244
2
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
3
Histamine Approved, Investigational Phase 4 75614-87-8, 51-45-6 774
4
Famotidine Approved Phase 4 76824-35-6 3325
5
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 4594 9579578
6
Clopidogrel Approved, Nutraceutical Phase 4,Phase 3 120202-66-6, 113665-84-2 60606
7
Proton pump inhibitors Phase 4,Phase 3
8 Gastrointestinal Agents Phase 4,Phase 3
9 Neurotransmitter Agents Phase 4,Phase 3
10 Antacids Phase 4,Phase 3
11 Fibrinolytic Agents Phase 4,Phase 3
12 Anti-Ulcer Agents Phase 4,Phase 3
13 calcium heparin Phase 4
14
Histamine Phosphate Phase 4 51-74-1 65513
15 Histamine Antagonists Phase 4
16 Histamine H2 Antagonists Phase 4
17
Lansoprazole Approved, Investigational Phase 3 103577-45-3 3883
18
Celecoxib Approved, Investigational Phase 3 169590-42-5 2662
19
Fluconazole Approved Phase 3 86386-73-4 3365
20
Naproxen Approved, Vet_approved Phase 3 22204-53-1 1302 156391
21
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
22
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613 2171
23
Metronidazole Approved Phase 3 443-48-1 4173
24
Cefuroxime Approved Phase 3 55268-75-2 5361202 5479529
25
Epinephrine Approved, Vet_approved Phase 3 51-43-4 5816
26
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
27
Ticlopidine Approved Phase 3 55142-85-3 5472
28
Dexlansoprazole Phase 3 138530-94-6, 103577-45-3 9578005
29 Analgesics Phase 3
30 Cyclooxygenase Inhibitors Phase 3
31 Analgesics, Non-Narcotic Phase 3
32 Peripheral Nervous System Agents Phase 3
33 Platelet Aggregation Inhibitors Phase 3
34 Anti-Inflammatory Agents Phase 3
35 Purinergic P2 Receptor Antagonists Phase 3
36 Purinergic P2Y Receptor Antagonists Phase 3
37 Anti-Inflammatory Agents, Non-Steroidal Phase 3
38 Antipyretics Phase 3
39 Antirheumatic Agents Phase 3
40 Clavulanic Acid Phase 3
41 cefuroxime axetil Phase 3
42 Steroid Synthesis Inhibitors Phase 3
43 Cyclooxygenase 2 Inhibitors Phase 3
44 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
45 Cytochrome P-450 Enzyme Inhibitors Phase 3
46 Hormone Antagonists Phase 3
47 Hormones Phase 3
48 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
49 Pharmaceutical Solutions Phase 3
50 Anti-Bacterial Agents Phase 3

Interventional clinical trials:

(show all 16)
id Name Status NCT ID Phase
1 Fast-track Surgery for Perforated Peptic Ulcers Completed NCT01620671 Phase 4
2 Prevention of Gastrointestinal Bleeding in Patients With Severe Ischemic Heart Disease Completed NCT00683111 Phase 4
3 Antibiotic Prophylaxis in the Prevention of Surgical Site Infections After Selected Urgent Abdominal Surgical Procedures Completed NCT01524081 Phase 3
4 A Comparison of Safety and Treatment in Subjects With Osteoarthritis Taking Low Dose Aspirin Completed NCT00175032 Phase 3
5 Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1) Terminated NCT00557921 Phase 3
6 Resolution Endoclips Vs Epinephrine Injection and Heater Probe Terminated NCT00165009 Phase 3
7 Peptic Ulcer Disease in Ischemic Heart Patients Taking Aspirin and Clopidogrel With or Without Proton Pump Inhibitor Unknown status NCT00854776
8 The Revolutions of Helicobacter Pylori Infection, Bacterial Density, and Histological Features After Antrectomy Unknown status NCT00441831
9 Peptic Ulcer Perforation Study Completed NCT00624169
10 The LAMA Trial: Laparoscopic Correction of Perforated Peptic Ulcer Versus Open Correction Completed NCT00745667
11 H. Pylori Testing for Patients With Non-specific Upper Abdominal Pain in the Emergency Department Completed NCT01376414
12 Feasibility of Translumenal Endoscopic Omental Patch Closure of Perforated Viscus Completed NCT01080326
13 Perforated Marginal Ulcer After Gastric Bypass Completed NCT01041196
14 Chronic Marginal Ulcers After Gastric Bypass Completed NCT01041079
15 Domestic Surgical Robot Clinical Study Recruiting NCT02752698
16 The Use of Over-the-scope-clip for Prevention of Rebleeding in High Risk Peptic Ulcers Not yet recruiting NCT03160911

Search NIH Clinical Center for Peptic Ulcer Perforation

Cochrane evidence based reviews: peptic ulcer perforation

Genetic Tests for Peptic Ulcer Perforation

Anatomical Context for Peptic Ulcer Perforation

MalaCards organs/tissues related to Peptic Ulcer Perforation:

39
Neutrophil

Publications for Peptic Ulcer Perforation

Articles related to Peptic Ulcer Perforation:

(show top 50) (show all 62)
id Title Authors Year
1
Triple gastric peptic ulcer perforation. ( 27193988 )
2016
2
Laparoscopic treatment experience of severe acute pancreatitis complicated by peptic ulcer perforation. ( 26875897 )
2016
3
Is the neutrophil-to-lymphocyte ratio a potential diagnostic marker for peptic ulcer perforation? A retrospective cohort study. ( 26643159 )
2016
4
Is history of ulcer an adverse factor for laparoscopic repair of peptic ulcer perforation? ( 25642867 )
2015
5
Laparoscopic Peptic Ulcer Perforation Closure: the Preferred Choice. ( 26730034 )
2015
6
Management of recurrent peptic ulcer perforation: problem-focused or definitive surgery? ( 24998336 )
2014
7
The growing role of laparoscopic repair in patients with early diagnosed peptic ulcer perforation. ( 25931911 )
2014
8
Prognostic Factors and Complications in Patients With Operational Peptic Ulcer Perforation in Northern Thailand. ( 27785262 )
2014
9
Long-term mortality following peptic ulcer perforation in the PULP trial. A nationwide follow-up study. ( 23215900 )
2013
10
The Perforation-Operation time Interval; An Important Mortality Indicator in Peptic Ulcer Perforation. ( 23814733 )
2013
11
Development of a simplified diagnostic indicators scoring system and validation for peptic ulcer perforation in a developing country. ( 23055764 )
2012
12
Sonographic diagnosis of peptic ulcer perforation. ( 22006560 )
2012
13
Accuracy of clinical prediction rules in peptic ulcer perforation: an observational study. ( 22126610 )
2012
14
The impact of Ramadan on peptic ulcer perforation. ( 23139002 )
2012
15
The Peptic Ulcer Perforation (PULP) score: a predictor of mortality following peptic ulcer perforation. A cohort study. ( 22191386 )
2012
16
The simple suture laparoscopic repair of peptic ulcer perforation without an omental patch. ( 21898018 )
2012
17
Diagnostic indicators for peptic ulcer perforation at a tertiary care hospital in Thailand. ( 22235172 )
2011
18
A safer technique of closure of peptic ulcer perforation. ( 23024542 )
2011
19
Multicentre trial of a perioperative protocol to reduce mortality in patients with peptic ulcer perforation. ( 21442610 )
2011
20
Preoperative prognostic factors for mortality in peptic ulcer perforation: a systematic review. ( 20384526 )
2010
21
Use of a fibrinogen- and thrombin-coated patch for peptic ulcer perforation repair. ( 19621657 )
2009
22
Gastro-duodenal peptic ulcer perforation. ( 19702096 )
2009
23
Risk factors in patients surgically treated for peptic ulcer perforation. ( 18785067 )
2009
24
Duration of survival after peptic ulcer perforation. ( 18172710 )
2008
25
Antipsychotic drugs and short-term mortality after peptic ulcer perforation: a population-based cohort study. ( 18637098 )
2008
26
Clinical trial: the incidence and early mortality after peptic ulcer perforation, and the use of low-dose aspirin and nonsteroidal anti-inflammatory drugs. ( 18644010 )
2008
27
Laparoscopic repair of peptic ulcer perforation without omental patch versus conventional open repair. ( 17907974 )
2007
28
Analysis of risk factors predicting (affecting) mortality and morbidity of peptic ulcer perforations. ( 17972470 )
2007
29
Peptic ulcer perforation as the first manifestation of previously unknown primary hyperparathyroidism. ( 21487467 )
2007
30
Persistence of Helicobacter pylori infection in patients with peptic ulcer perforation. ( 17354111 )
2007
31
Factors affecting mortality and morbidity in patients with peptic ulcer perforation. ( 17376052 )
2007
32
Duodeno-pleural fistula: a rare complication of peptic ulcer perforation. ( 16986297 )
2006
33
Peptic ulcer perforation: sonographic imaging of active fluid leakage. ( 16353234 )
2006
34
30-day mortality after peptic ulcer perforation among users of newer selective COX-2 inhibitors and traditional NSAIDs: a population-based study. ( 17026569 )
2006
35
Peptic ulcer perforation: management of high-risk cases by percutaneous abdominal drainage. ( 15712542 )
2005
36
Is there any role of acid reducing gastric surgery in peptic ulcer perforation? ( 16623058 )
2005
37
Prognostic factors of peptic ulcer perforation. ( 16127525 )
2005
38
A simplified prognostic scoring system for peptic ulcer perforation in developing countries. ( 12696822 )
2003
39
Experience of peptic ulcer perforation over a decade in a teaching hospital of southern Bangladesh. ( 12971209 )
2003
40
Causes of death in patients with peptic ulcer perforation: a long-term follow-up study. ( 10048727 )
1999
41
Surgical approach and prognostic factors after peptic ulcer perforation. ( 10433141 )
1999
42
Acute gastroduodenal peptic ulcer perforation: contrast-enhanced and thin-section spiral CT findings in 10 patients. ( 10390552 )
1999
43
Rhythmic patterns in incidence of peptic ulcer perforation over 5.5 decades in Norway. ( 9653578 )
1998
44
Density of Helicobacter pylori infection in patients with peptic ulcer perforation. ( 9632154 )
1998
45
Peptic ulcer perforation before and after the introduction of H2-receptor blockers and proton pump inhibitors. ( 9200281 )
1997
46
Survival after peptic ulcer perforation: a time trend analysis. ( 8970486 )
1996
47
Society stress and peptic ulcer perforation. ( 8963033 )
1995
48
Intramuscular Toradol, gastrointestinal bleeding, and peptic ulcer perforation: a case report. ( 7731074 )
1995
49
Peptic ulcer perforation as the presentation of Zollinger-Ellison syndrome. ( 1984999 )
1991
50
Peptic ulcer perforation: a complication of double contrast barium meal examination. ( 2799373 )
1989

Variations for Peptic Ulcer Perforation

Expression for Peptic Ulcer Perforation

Search GEO for disease gene expression data for Peptic Ulcer Perforation.

Pathways for Peptic Ulcer Perforation

Pathways related to Peptic Ulcer Perforation according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.53 CHL1 EZR ITGA2
2
Show member pathways
11.47 ATP4A EZR GAST HRH2
3 10.43 CRP PTGS2
4 9.5 ATP4A GAST HRH2

GO Terms for Peptic Ulcer Perforation

Cellular components related to Peptic Ulcer Perforation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 8.92 ALB AMELX CD4 PTGS2

Biological processes related to Peptic Ulcer Perforation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine production GO:0001816 9.37 CD4 S100A8
2 positive regulation of smooth muscle contraction GO:0045987 9.32 ITGA2 PTGS2
3 response to vitamin D GO:0033280 9.26 CD4 PTGS2
4 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.16 ATP12A ATP4A
5 positive regulation of phagocytosis, engulfment GO:0060100 8.96 ANO6 ITGA2
6 tooth mineralization GO:0034505 8.62 AMELX AMELY

Molecular functions related to Peptic Ulcer Perforation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP12A ATP4A
2 structural constituent of tooth enamel GO:0030345 8.96 AMELX AMELY
3 hydrogen:potassium-exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Peptic Ulcer Perforation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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