MCID: PPT002
MIFTS: 37

Peptic Ulcer Perforation

Categories: Gastrointestinal diseases

Aliases & Classifications for Peptic Ulcer Perforation

MalaCards integrated aliases for Peptic Ulcer Perforation:

Name: Peptic Ulcer Perforation 12 42 14 69
Perforated Peptic Ulcer 12 52
Unspecified Peptic Ulcer with Perforation 12
Acute Peptic Ulcer with Perforation 12
Peptic Ulcer with Perforation 12

Classifications:



External Ids:

Disease Ontology 12 DOID:752
MeSH 42 D010439
UMLS 69 C0030925

Summaries for Peptic Ulcer Perforation

MalaCards based summary : Peptic Ulcer Perforation, also known as perforated peptic ulcer, is related to peptic ulcer disease and rhabdomyosarcoma. An important gene associated with Peptic Ulcer Perforation is ATP4A (ATPase H+/K+ Transporting Alpha Subunit), and among its related pathways/superpathways are Salivary secretion and Overview of nanoparticle effects. The drugs Aspirin and Esomeprazole have been mentioned in the context of this disorder. Affiliated tissues include heart, spleen and testes, and related phenotypes are Decreased caspase 3/7 activity and digestive/alimentary

Related Diseases for Peptic Ulcer Perforation

Diseases related to Peptic Ulcer Perforation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
id Related Disease Score Top Affiliating Genes
1 peptic ulcer disease 11.6
2 rhabdomyosarcoma 10.8 ATP4A HRH2
3 vascular disease 10.8 ALB ATP4A
4 lacrimal apparatus disease 10.8 ATP4A HRH2
5 scrotal carcinoma 10.8 ATP4A HRH2
6 arrhythmogenic right ventricular dysplasia 3 10.8 AMELX AMELY
7 chronic gonococcal salpingitis 10.8 ALB ATP4A
8 ocular cancer 10.7 AMELX AMELY
9 pineal region yolk sac tumor 10.7 AMELX AMELY
10 thymus mucoepidermoid carcinoma 10.7 AMELX AMELY
11 retinitis pigmentosa 59 10.7 AMELX AMELY
12 cushing's syndrome 10.7 ATP4A PTGS2
13 mental retardation, x-linked 104 10.7 AMELX AMELY
14 capillary leak syndrome 10.7 ALB CRP
15 accommodative spasm 10.7 AMELX AMELY
16 myelomeningocele 10.7 AMELX CRP
17 angelucci's syndrome 10.6 ALB ATP4A
18 speech and communication disorders 10.6 ALB CRP
19 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids 10.6 ALB CD4
20 milker's nodule 10.6 ALB CRP
21 neuroschistosomiasis 10.6 AMELX AMELY
22 brain ependymoma 10.5 ATP4A HRH2 PTGS2
23 ovary transitional cell carcinoma 10.5 ALB GAST
24 cryptogenic organizing pneumonia 10.5 ALB ATP4A CRP
25 substance-induced psychosis 10.5 ATP4A GAST
26 cystinosis 10.5 ALB CRP HRH2
27 small intestinal vasoactive intestinal peptide producing tumor 10.5 CRP PTGS2
28 congenital aphakia 10.5 ATP12A ATP4A
29 urethral calculus 10.5 ATP12A ATP4A
30 breast ductal adenoma 10.5 ATP12A ATP4A
31 hypopituitarism 10.5 ATP12A ATP4A
32 amyotrophic lateral sclerosis type 5 10.5 ATP12A ATP4A
33 abnormal pupillary function 10.5 ATP12A ATP4A
34 female breast upper-inner quadrant cancer 10.5 AMELX AMELY CRP
35 atheroembolism of kidney 10.4 ATP12A ATP4A
36 bacterial gastritis 10.4 AMELX AMELY CRP
37 microphthalmia, syndromic 12 10.4 ATP12A ATP4A
38 focal hand dystonia 10.4 ATP12A ATP4A
39 cloacal exstrophy 10.4 ATP12A ATP4A
40 bronchus cancer 10.4 AMELX AMELY
41 thrombocytopenia due to platelet alloimmunization 10.4 ATP12A ATP4A
42 proliferative fasciitis 10.4 ATP12A ATP4A
43 hodgkin's paragranuloma 10.3 ATP12A ATP4A
44 spinocerebellar ataxia 18 10.3 ATP12A ATP4A
45 dermatomycosis 10.3 ALB CRP
46 iris mixed cell melanoma 10.3 GAST HRH2
47 adult xanthogranuloma 10.3 ATP12A ATP4A HRH2
48 bladder neck cancer 10.3 ATP12A ATP4A HRH2
49 heart disease 10.2 CRP EZR
50 polysyndactyly with cardiac malformation 10.2 ALB ATP12A ATP4A

Graphical network of the top 20 diseases related to Peptic Ulcer Perforation:



Diseases related to Peptic Ulcer Perforation

Symptoms & Phenotypes for Peptic Ulcer Perforation

GenomeRNAi Phenotypes related to Peptic Ulcer Perforation according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased caspase 3/7 activity GR00318-A 8.8 CD4 GAST HRH2

MGI Mouse Phenotypes related to Peptic Ulcer Perforation:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.23 GAST HRH2 PTGS2 ALB ATP12A ATP4A

Drugs & Therapeutics for Peptic Ulcer Perforation

Drugs for Peptic Ulcer Perforation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 70)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 3 50-78-2 2244
2
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 4594 9579578
3
Famotidine Approved Phase 4 76824-35-6 3325
4
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
5
Histamine Approved, Investigational Phase 4 75614-87-8, 51-45-6 774
6
Clopidogrel Approved, Nutraceutical Phase 4,Phase 3 120202-66-6, 113665-84-2 60606
7 Antacids Phase 4,Phase 3
8 Anti-Ulcer Agents Phase 4,Phase 3
9 Fibrinolytic Agents Phase 4,Phase 3
10 Gastrointestinal Agents Phase 4,Phase 3
11 Neurotransmitter Agents Phase 4,Phase 3
12
Proton pump inhibitors Phase 4,Phase 3
13 calcium heparin Phase 4
14 Histamine Antagonists Phase 4
15 Histamine H2 Antagonists Phase 4
16
Histamine Phosphate Phase 4 51-74-1 65513
17
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613 2171
18
Cefuroxime Approved Phase 3 55268-75-2 5361202 5479529
19
Fluconazole Approved Phase 3 86386-73-4 3365
20
Metronidazole Approved Phase 3 443-48-1 4173
21
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
22
Epinephrine Approved, Vet_approved Phase 3 51-43-4 5816
23 Racepinephrine Approved Phase 3
24
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
25
Ticlopidine Approved Phase 3 55142-85-3 5472
26 Analgesics Phase 3
27 Analgesics, Non-Narcotic Phase 3
28 Anti-Inflammatory Agents Phase 3
29 Anti-Inflammatory Agents, Non-Steroidal Phase 3
30 Antipyretics Phase 3
31 Antirheumatic Agents Phase 3
32 Cyclooxygenase Inhibitors Phase 3
33 Peripheral Nervous System Agents Phase 3
34 Platelet Aggregation Inhibitors Phase 3
35 Purinergic P2 Receptor Antagonists Phase 3
36 Purinergic P2Y Receptor Antagonists Phase 3
37 Anti-Bacterial Agents Phase 3
38 Antibiotics, Antitubercular Phase 3
39 Antifungal Agents Phase 3
40 Anti-Infective Agents Phase 3
41 Antiparasitic Agents Phase 3
42 Antiprotozoal Agents Phase 3
43 Antitubercular Agents Phase 3
44 beta-Lactamase Inhibitors Phase 3
45 cefuroxime axetil Phase 3
46 Clavulanic Acid Phase 3
47 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
48 Cytochrome P-450 Enzyme Inhibitors Phase 3
49 Hormone Antagonists Phase 3
50 Hormones Phase 3

Interventional clinical trials:

(show all 14)

id Name Status NCT ID Phase Drugs
1 Fast-track Surgery for Perforated Peptic Ulcers Completed NCT01620671 Phase 4
2 Prevention of Gastrointestinal Bleeding in Patients With Severe Ischemic Heart Disease Completed NCT00683111 Phase 4 esomeprazole 20 mg daily;famotidine 40 mg daily
3 Antibiotic Prophylaxis in the Prevention of Surgical Site Infections After Selected Urgent Abdominal Surgical Procedures Completed NCT01524081 Phase 3 Metronidazole, Cefuroxime;Amoxicillin (+ clavulanic acid) and Fluconazole;Placebo;Placebo
4 Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1) Terminated NCT00557921 Phase 3 CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin;Plavix (clopidogrel 75 mg) and aspirin
5 Resolution Endoclips Vs Epinephrine Injection and Heater Probe Terminated NCT00165009 Phase 3
6 Peptic Ulcer Disease in Ischemic Heart Patients Taking Aspirin and Clopidogrel With or Without Proton Pump Inhibitor Unknown status NCT00854776 lansoprazole;aluminum hydroxide 334 mg and Mg hydroxide 166 mg
7 The Revolutions of Helicobacter Pylori Infection, Bacterial Density, and Histological Features After Antrectomy Unknown status NCT00441831
8 Peptic Ulcer Perforation Study Completed NCT00624169
9 The LAMA Trial: Laparoscopic Correction of Perforated Peptic Ulcer Versus Open Correction Completed NCT00745667
10 H. Pylori Testing for Patients With Non-specific Upper Abdominal Pain in the Emergency Department Completed NCT01376414
11 Feasibility of Translumenal Endoscopic Omental Patch Closure of Perforated Viscus Completed NCT01080326
12 Perforated Marginal Ulcer After Gastric Bypass Completed NCT01041196
13 Function of Jiangzhong Hou Gu® Mi Xi™ in Patients With Spleen Qi Deficiency and Peptic Ulcer Diseases Recruiting NCT03320538 Rabeprazole
14 The Use of Over-the-scope-clip for Prevention of Rebleeding in High Risk Peptic Ulcers Not yet recruiting NCT03160911

Search NIH Clinical Center for Peptic Ulcer Perforation

Cochrane evidence based reviews: peptic ulcer perforation

Genetic Tests for Peptic Ulcer Perforation

Anatomical Context for Peptic Ulcer Perforation

MalaCards organs/tissues related to Peptic Ulcer Perforation:

39
Heart, Spleen, Testes, Neutrophil

Publications for Peptic Ulcer Perforation

Articles related to Peptic Ulcer Perforation:

(show top 50) (show all 64)
id Title Authors Year
1
Clinical characteristics of peptic ulcer perforation in Korea. ( 28465641 )
2017
2
Preoperative factors influencing mortality and morbidity in peptic ulcer perforation. ( 28258286 )
2017
3
Is the neutrophil-to-lymphocyte ratio a potential diagnostic marker for peptic ulcer perforation? A retrospective cohort study. ( 26643159 )
2016
4
Laparoscopic treatment experience of severe acute pancreatitis complicated by peptic ulcer perforation. ( 26875897 )
2016
5
Triple gastric peptic ulcer perforation. ( 27193988 )
2016
6
Is history of ulcer an adverse factor for laparoscopic repair of peptic ulcer perforation? ( 25642867 )
2015
7
Laparoscopic Peptic Ulcer Perforation Closure: the Preferred Choice. ( 26730034 )
2015
8
The growing role of laparoscopic repair in patients with early diagnosed peptic ulcer perforation. ( 25931911 )
2014
9
Management of recurrent peptic ulcer perforation: problem-focused or definitive surgery? ( 24998336 )
2014
10
Prognostic Factors and Complications in Patients With Operational Peptic Ulcer Perforation in Northern Thailand. ( 27785262 )
2014
11
Long-term mortality following peptic ulcer perforation in the PULP trial. A nationwide follow-up study. ( 23215900 )
2013
12
The Perforation-Operation time Interval; An Important Mortality Indicator in Peptic Ulcer Perforation. ( 23814733 )
2013
13
The Peptic Ulcer Perforation (PULP) score: a predictor of mortality following peptic ulcer perforation. A cohort study. ( 22191386 )
2012
14
The impact of Ramadan on peptic ulcer perforation. ( 23139002 )
2012
15
Accuracy of clinical prediction rules in peptic ulcer perforation: an observational study. ( 22126610 )
2012
16
The simple suture laparoscopic repair of peptic ulcer perforation without an omental patch. ( 21898018 )
2012
17
Development of a simplified diagnostic indicators scoring system and validation for peptic ulcer perforation in a developing country. ( 23055764 )
2012
18
Sonographic diagnosis of peptic ulcer perforation. ( 22006560 )
2012
19
A safer technique of closure of peptic ulcer perforation. ( 23024542 )
2011
20
Multicentre trial of a perioperative protocol to reduce mortality in patients with peptic ulcer perforation. ( 21442610 )
2011
21
Diagnostic indicators for peptic ulcer perforation at a tertiary care hospital in Thailand. ( 22235172 )
2011
22
Preoperative prognostic factors for mortality in peptic ulcer perforation: a systematic review. ( 20384526 )
2010
23
Use of a fibrinogen- and thrombin-coated patch for peptic ulcer perforation repair. ( 19621657 )
2009
24
Risk factors in patients surgically treated for peptic ulcer perforation. ( 18785067 )
2009
25
Gastro-duodenal peptic ulcer perforation. ( 19702096 )
2009
26
Antipsychotic drugs and short-term mortality after peptic ulcer perforation: a population-based cohort study. ( 18637098 )
2008
27
Clinical trial: the incidence and early mortality after peptic ulcer perforation, and the use of low-dose aspirin and nonsteroidal anti-inflammatory drugs. ( 18644010 )
2008
28
Duration of survival after peptic ulcer perforation. ( 18172710 )
2008
29
Analysis of risk factors predicting (affecting) mortality and morbidity of peptic ulcer perforations. ( 17972470 )
2007
30
Persistence of Helicobacter pylori infection in patients with peptic ulcer perforation. ( 17354111 )
2007
31
Peptic ulcer perforation as the first manifestation of previously unknown primary hyperparathyroidism. ( 21487467 )
2007
32
Laparoscopic repair of peptic ulcer perforation without omental patch versus conventional open repair. ( 17907974 )
2007
33
Factors affecting mortality and morbidity in patients with peptic ulcer perforation. ( 17376052 )
2007
34
Duodeno-pleural fistula: a rare complication of peptic ulcer perforation. ( 16986297 )
2006
35
30-day mortality after peptic ulcer perforation among users of newer selective COX-2 inhibitors and traditional NSAIDs: a population-based study. ( 17026569 )
2006
36
Peptic ulcer perforation: sonographic imaging of active fluid leakage. ( 16353234 )
2006
37
Is there any role of acid reducing gastric surgery in peptic ulcer perforation? ( 16623058 )
2005
38
Peptic ulcer perforation: management of high-risk cases by percutaneous abdominal drainage. ( 15712542 )
2005
39
Prognostic factors of peptic ulcer perforation. ( 16127525 )
2005
40
A simplified prognostic scoring system for peptic ulcer perforation in developing countries. ( 12696822 )
2003
41
Experience of peptic ulcer perforation over a decade in a teaching hospital of southern Bangladesh. ( 12971209 )
2003
42
Surgical approach and prognostic factors after peptic ulcer perforation. ( 10433141 )
1999
43
Causes of death in patients with peptic ulcer perforation: a long-term follow-up study. ( 10048727 )
1999
44
Acute gastroduodenal peptic ulcer perforation: contrast-enhanced and thin-section spiral CT findings in 10 patients. ( 10390552 )
1999
45
Rhythmic patterns in incidence of peptic ulcer perforation over 5.5 decades in Norway. ( 9653578 )
1998
46
Density of Helicobacter pylori infection in patients with peptic ulcer perforation. ( 9632154 )
1998
47
Peptic ulcer perforation before and after the introduction of H2-receptor blockers and proton pump inhibitors. ( 9200281 )
1997
48
Survival after peptic ulcer perforation: a time trend analysis. ( 8970486 )
1996
49
Intramuscular Toradol, gastrointestinal bleeding, and peptic ulcer perforation: a case report. ( 7731074 )
1995
50
Society stress and peptic ulcer perforation. ( 8963033 )
1995

Variations for Peptic Ulcer Perforation

Expression for Peptic Ulcer Perforation

Search GEO for disease gene expression data for Peptic Ulcer Perforation.

Pathways for Peptic Ulcer Perforation

Pathways related to Peptic Ulcer Perforation according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.47 ATP4A EZR GAST HRH2
2 10.43 CRP PTGS2
3 9.5 ATP4A GAST HRH2

GO Terms for Peptic Ulcer Perforation

Cellular components related to Peptic Ulcer Perforation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 8.92 ALB AMELX CD4 PTGS2

Biological processes related to Peptic Ulcer Perforation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine production GO:0001816 9.26 CD4 S100A8
2 response to vitamin D GO:0033280 9.16 CD4 PTGS2
3 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.96 ATP12A ATP4A
4 tooth mineralization GO:0034505 8.62 AMELX AMELY

Molecular functions related to Peptic Ulcer Perforation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP12A ATP4A
2 structural constituent of tooth enamel GO:0030345 8.96 AMELX AMELY
3 hydrogen:potassium-exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Peptic Ulcer Perforation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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