MCID: PRM014
MIFTS: 41

Periampullary Adenocarcinoma malady

Cancer diseases category
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Summaries for Periampullary Adenocarcinoma

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MalaCards based summary: Periampullary Adenocarcinoma is related to adenocarcinoma and pancreatitis. An important gene associated with Periampullary Adenocarcinoma is CDKN1B (cyclin-dependent kinase inhibitor 1B (p27, Kip1)), and among its related pathways are Celecoxib Pathway, Pharmacodynamics and Integrins in angiogenesis. The compounds 3,3-diindolylmethane and azoxymethane have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and endothelial, and related mouse phenotypes are renal/urinary system and muscle.

Aliases & Classifications for Periampullary Adenocarcinoma

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Periampullary Adenocarcinoma, Aliases & Descriptions:

Name: Periampullary Adenocarcinoma 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:8110
NCIt39 C27322

Related Diseases for Periampullary Adenocarcinoma

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Diseases related to Periampullary Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.8VEGFA, CCND1, BAX, CDKN1B
2pancreatitis10.5
3paraganglioma10.2
4gastric outlet obstruction10.2
5endotheliitis10.2
6gallbladder cancer10.1CDKN1B, BAX
7acute lymphoblastic leukemia, childhood10.1BAX, CDKN1B
8acute promyelocytic leukemia10.1BAX, CDKN1B
9hematologic cancer10.1VEGFA, CDKN1B
10bladder carcinoma10.1BAX, CDKN1B
11colon adenocarcinoma10.1BAX, CDKN1B
12precursor t-cell acute lymphoblastic leukemia10.1BAX, CDKN1B
13congenital heart disease10.1BAX, VEGFA
14lung cancer10.0CCND1, VEGFA
15parathyroid adenoma10.0CCND1, CDKN1B
16glioblastoma multiforme10.0VEGFA, BAX
17esophageal cancer10.0CDKN1B, CCND1
18esophageal squamous cell carcinoma10.0BAX, CCND1
19pancreatic cancer10.0VEGFA, CCND1
20thyroid hurthle cell carcinoma10.0CDKN1B, CCND1
21papillary thyroid carcinoma10.0BAX, CCND1
22vascular disease10.0VEGFA, BAX
23cervical cancer9.9BAX, CDKN1B
24breast cancer9.9CCND1, CDKN1B
25kidney cancer9.9CDKN1B, VEGFA, BAX
26malignant glioma9.9CDKN1B, VEGFA, BAX
27chronic lymphocytic leukemia9.8CCND1, BAX
28laryngeal squamous cell carcinoma9.8BAX, VEGFA, CCND1
29follicular lymphoma9.8CCND1, BAX, CDKN1B
30oral cancer9.8CCND1, BAX, CDKN1B
31non-small cell lung carcinoma9.8CCND1, VEGFA, BAX
32b-cell lymphomas9.8CCND1, CDKN1B, BAX
33myeloma9.8BAX, CCND1, VEGFA
34retinoblastoma9.8CDKN1B, CCND1, BAX
35adenoma9.8CCND1, BAX, CDKN1B
36squamous cell carcinoma of the head and neck9.8VEGFA, CCND1
37burkitt's lymphoma9.8CCND1, CDKN1B, BAX
38leukemia9.7BAX, CCND1, CDKN1B
39lung adenocarcinoma9.6CCND1, BAX, CDKN1B, VEGFA
40endometrial carcinoma9.6VEGFA, CCND1, BAX, CDKN1B
41glioblastoma9.6VEGFA, CDKN1B, CCND1, BAX
42stomach cancer9.6CCND1, VEGFA, CDKN1B, BAX
43ovarian cancer9.6BAX, CCND1, VEGFA, CDKN1B
44colonic benign neoplasm9.6BAX, VEGFA, CCND1, CDKN1B
45liver cancer9.6BAX, CCND1, VEGFA, CDKN1B
46colorectal cancer9.6CCND1, CDKN1B, BAX, VEGFA
47tongue squamous cell carcinoma9.6VEGFA, CCND1, BAX, CDKN1B
48melanoma9.6BAX, CCND1, VEGFA, CDKN1B
49prostate cancer9.6CDKN1B, BAX, VEGFA, CCND1

Graphical network of the top 20 diseases related to Periampullary Adenocarcinoma:



Diseases related to periampullary adenocarcinoma

Symptoms for Periampullary Adenocarcinoma

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Drugs & Therapeutics for Periampullary Adenocarcinoma

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Drug clinical trials:

Search ClinicalTrials for Periampullary Adenocarcinoma

Search NIH Clinical Center for Periampullary Adenocarcinoma

Genetic Tests for Periampullary Adenocarcinoma

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Anatomical Context for Periampullary Adenocarcinoma

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MalaCards organs/tissues related to Periampullary Adenocarcinoma:

32
Liver, Pancreas, Endothelial

Animal Models for Periampullary Adenocarcinoma or affiliated genes

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Publications for Periampullary Adenocarcinoma

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Articles related to Periampullary Adenocarcinoma:

(show all 39)
idTitleAuthorsYear
1
Reduced expression of the polymeric immunoglobulin receptor in pancreatic and periampullary adenocarcinoma signifies tumour progression and poor prognosis. (25397670)
2014
2
Prognostic and treatment predictive significance of SATB1 and SATB2 expression in pancreatic and periampullary adenocarcinoma. (25323550)
2014
3
Use of a standardized diagnostic approach improves the prognostic information of histopathologic factors in pancreatic and periampullary adenocarcinoma. (24731283)
2014
4
FAP related periampullary adenocarcinoma. (23792481)
2013
5
Large retroperitoneal paraganglioma concurrent with periampullary adenocarcinoma. (24523807)
2013
6
Ampullary and periampullary adenocarcinoma: new challenges in management of recurrence. (23474562)
2013
7
Resection of isolated local and metastatic recurrence in periampullary adenocarcinoma. (23601033)
2013
8
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial. (22782416)
2012
9
Prognostic significance of tumour location after adjuvant chemoradiotherapy for periampullary adenocarcinoma. (22551547)
2012
10
Adjuvant chemotherapy for resected periampullary adenocarcinoma. (23149995)
2012
11
Pancreatobiliary versus intestinal histologic type of differentiation is an independent prognostic factor in resected periampullary adenocarcinoma. (18547417)
2008
12
Results of pancreaticoduodenectomy in patients with periampullary adenocarcinoma: perineural growth more important prognostic factor than tumor localization. (18580212)
2008
13
Pancreaticoduodenectomy with extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma. (17336242)
2007
14
Resected periampullary adenocarcinoma: 5-year survivors and their 6- to 10-year follow-up. (17084719)
2006
15
Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma--part 3: update on 5-year survival. (16332474)
2005
16
Survival after attempted surgical resection and intraoperative radiation therapy for pancreatic and periampullary adenocarcinoma. (15978737)
2005
17
Neoadjuvant therapy and biliary decompression lower biliary and pancreatic juice vascular endothelial growth factor levels in patients with periampullary adenocarcinoma. (15011922)
2004
18
Recurrent disease after microscopically radical (R0) resection of periampullary adenocarcinoma in patients without adjuvant therapy. (15531230)
2004
19
Cyclin D1 and bax influence the prognosis after pancreatoduodenectomy for periampullary adenocarcinoma. (15532837)
2004
20
Standard vs. radical pancreaticoduodenectomy for periampullary adenocarcinoma: a prospective, randomized trial evaluating quality of life in pancreaticoduodenectomy survivors. (12559179)
2003
21
Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma, part 2: randomized controlled trial evaluating survival, morbidity, and mortality. (12192322)
2002
22
Survival after pancreaticoduodenectomy for periampullary adenocarcinoma: an update. (11520088)
2001
23
The Johns Hopkins experience with pancreaticoduodenectomy with or without extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma. (10939866)
2000
24
Intensified adjuvant combined modality therapy for resected periampullary adenocarcinoma: acceptable toxicity and suggestion of improved 1-year disease-free survival. (11072167)
2000
25
Prospective study of gastric outlet obstruction in unresectable periampullary adenocarcinoma. (10594205)
2000
26
Intensified adjuvant therapy for pancreatic and periampullary adenocarcinoma: survival results and observations regarding patterns of failure, radiotherapy dose and CA19-9 levels. (10421536)
1999
27
Implications of histological grade of tumour for the prognosis of radically resected periampullary adenocarcinoma. (10533763)
1999
28
Surgical palliation of unresectable periampullary adenocarcinoma in the 1990s. (10359359)
1999
29
Periampullary adenocarcinoma: analysis of 5-year survivors. (10561100)
1999
30
Primary nonampullary/periampullary adenocarcinoma of the duodenum. (9843337)
1998
31
Periampullary adenocarcinoma: analysis of 5-year survivors. (9637545)
1998
32
A study of forty-nine consecutive Whipple resections for periampullary adenocarcinoma. (9240943)
1997
33
Improved results for resection of periampullary adenocarcinoma. (9184871)
1996
34
Clinical behavior and prognostic factors of periampullary adenocarcinoma. (7487210)
1995
35
Pancreaticoduodenectomy for periampullary adenocarcinoma. (7952456)
1994
36
Cytogenetic characterization of a periampullary adenocarcinoma of the pancreas, its liver metastasis, and a cell line established from the metastasis and a cell line established from the metastasis in a patient with Gardner's syndrome. (8076346)
1994
37
Mixed cellular population in primary and metastatic periampullary adenocarcinoma of the duodenum: report of a case. (7633200)
1994
38
Reoperative surgery for periampullary adenocarcinoma. (1681794)
1991
39
Periampullary adenocarcinoma of the duodenum. (13253908)
1955

Variations for Periampullary Adenocarcinoma

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Expression for genes affiliated with Periampullary Adenocarcinoma

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Expression patterns in normal tissues for genes affiliated with Periampullary Adenocarcinoma

Search GEO for disease gene expression data for Periampullary Adenocarcinoma.

Pathways for genes affiliated with Periampullary Adenocarcinoma

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Pathways related to Periampullary Adenocarcinoma according to GeneCards/GeneDecks:

(show all 48)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CDKN1B, VEGFA
29.4VEGFA, CDKN1B
39.4CDKN1B, VEGFA
4
Show member pathways
AhR pathway37
9.3CDKN1B, BAX
59.3CDKN1B, BAX
69.1CDKN1B, CCND1
79.1CDKN1B, CCND1
89.1CCND1, CDKN1B
9
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.1CDKN1B, CCND1
109.1CDKN1B, CCND1
119.1CDKN1B, CCND1
129.1CDKN1B, CCND1
139.1CCND1, CDKN1B
14
Show member pathways
9.1CCND1, CDKN1B
159.1CDKN1B, CCND1
16
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.1CDKN1B, CCND1
17
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.1CDKN1B, CCND1
18
Show member pathways
Cell cycle ESR1 regulation of G1 S transition60
Immune response MIF JAB1 signaling60
Cell cycle Cell cycle generic schema 60
9.1CCND1, CDKN1B
19
Show member pathways
9.1CCND1, CDKN1B
20
Show member pathways
9.1CDKN1B, CCND1
21
Show member pathways
9.1CDKN1B, CCND1
22
Show member pathways
Cell cycle37
9.1CDKN1B, CCND1
23
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
9.1CCND1, CDKN1B
249.1CCND1, VEGFA
25
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
9.1CCND1, VEGFA
26
Show member pathways
9.0BAX, CCND1
279.0BAX, CCND1
28
Show member pathways
Signal transduction PTEN pathway60
9.0BAX, CCND1
29
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
9.0CCND1, BAX
30
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
9.0BAX, CCND1
31
Show member pathways
8.6CDKN1B, CCND1, VEGFA
32
Show member pathways
Signaling Pathways in Glioblastoma37
8.6CDKN1B, CCND1, VEGFA
33
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
8.6VEGFA, CCND1, CDKN1B
348.6CDKN1B, CCND1, VEGFA
358.6CDKN1B, CCND1, VEGFA
36
Show member pathways
8.5CDKN1B, BAX, CCND1
37
Show member pathways
8.5CCND1, BAX, CDKN1B
38
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
8.5CDKN1B, BAX, CCND1
39
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
8.5CCND1, BAX, CDKN1B
40
Show member pathways
DNA damage response37
8.5CDKN1B, BAX, CCND1
418.5CCND1, BAX, CDKN1B
42
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
8.5CCND1, BAX, CDKN1B
43
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I60
8.5CDKN1B, BAX, CCND1
44
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.5CDKN1B, BAX, CCND1
45
Show member pathways
8.5CCND1, BAX, CDKN1B
468.5BAX, CCND1, VEGFA
478.0VEGFA, CCND1, BAX, CDKN1B
488.0CDKN1B, BAX, CCND1, VEGFA

Compounds for genes affiliated with Periampullary Adenocarcinoma

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Compounds related to Periampullary Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
13,3-diindolylmethane449.5BAX, VEGFA
2azoxymethane449.4CDKN1B, CCND1
3inostamycin449.4BAX, CCND1
4mimosine44 1110.3CCND1, CDKN1B
5ursolic acid449.3BAX, CCND1
6norcantharidin449.3CCND1, BAX
7ginsenoside449.3BAX, CCND1
8exisulind449.3BAX, CCND1
9everolimus44 50 1111.2VEGFA, CCND1
10gossypol449.2CCND1, BAX
115fluorouracil449.1CDKN1B, BAX, VEGFA
12apigenin44 2810.0CCND1, BAX
13phenethyl isothiocyanate2 4410.0BAX, CCND1
14cetuximab44 50 1111.0VEGFA, CCND1, CDKN1B
15ns 39844 6110.0VEGFA, CCND1, CDKN1B
16erlotinib44 50 1111.0VEGFA, CCND1, CDKN1B
17trastuzumab44 50 1111.0VEGFA, CCND1, CDKN1B
18gefitinib44 50 1111.0CDKN1B, CCND1, VEGFA
19imatinib44 50 1110.9VEGFA, CCND1, CDKN1B
20pd 169316448.9BAX, CCND1, VEGFA
21eb 108944 619.9CCND1, BAX, CDKN1B
22ciglitazone44 289.9CDKN1B, BAX, CCND1
23indole-3-carbinol448.9CDKN1B, BAX, CCND1
24thymidylate448.9VEGFA, CCND1, BAX
25troglitazone44 28 61 1111.9CDKN1B, BAX, CCND1
26curcumin448.8BAX, CCND1, VEGFA
27arsenite44 249.8VEGFA, CCND1, BAX
28olomoucine44 119.7BAX, CCND1
29butyrate448.7CCND1, BAX, CDKN1B
30rapamycin448.7CDKN1B, CCND1, VEGFA
31flavopiridol44 119.4CDKN1B, BAX, CCND1, VEGFA
32celecoxib44 61 28 50 24 1113.4VEGFA, CCND1, BAX, CDKN1B
33bortezomib44 50 1110.4VEGFA, CCND1, BAX, CDKN1B
34gemcitabine44 50 1110.4CDKN1B, BAX, CCND1, VEGFA
35resveratrol44 61 24 1111.4VEGFA, CCND1, BAX, CDKN1B
36egcg448.4VEGFA, CCND1, BAX, CDKN1B
37mg 13244 619.4VEGFA, CCND1, BAX, CDKN1B
38n acetylcysteine448.4VEGFA, CCND1, BAX, CDKN1B
39sb 20358044 619.4CDKN1B, BAX, CCND1, VEGFA
40tamoxifen44 50 28 1111.4CDKN1B, BAX, CCND1, VEGFA
41pd 98,059448.4CDKN1B, BAX, CCND1
42paclitaxel44 50 1110.4VEGFA, CCND1, BAX, CDKN1B
43ly294002448.4CDKN1B, BAX, CCND1, VEGFA
44doxorubicin44 50 1110.4CDKN1B, BAX, CCND1, VEGFA
45paraffin448.4CDKN1B, BAX, CCND1, VEGFA
46genistein44 28 61 2 24 1113.4VEGFA, CCND1, BAX, CDKN1B
47cisplatin44 50 61 1111.4CDKN1B, BAX, CCND1, VEGFA
48cycloheximide448.4CDKN1B, BAX, CCND1, VEGFA
49vegf448.3CDKN1B, BAX, CCND1, VEGFA
50estrogen448.3CDKN1B, BAX, CCND1, VEGFA

GO Terms for genes affiliated with Periampullary Adenocarcinoma

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Biological processes related to Periampullary Adenocarcinoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1ovarian follicle developmentGO:0015419.5BAX, VEGFA
2response to hypoxiaGO:0016669.4CDKN1B, VEGFA
3activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.4CDKN1B, BAX
4kidney developmentGO:0018229.3VEGFA, BAX
5mammary gland alveolus developmentGO:0607499.3CCND1, VEGFA
6lactationGO:0075959.2CCND1, VEGFA
7positive regulation of protein phosphorylationGO:0019349.0CCND1, VEGFA
8G1/S transition of mitotic cell cycleGO:0000828.8CDKN1B, CCND1

Molecular functions related to Periampullary Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complex bindingGO:0324039.1CDKN1B, CCND1

Products for genes affiliated with Periampullary Adenocarcinoma

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Sources for Periampullary Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet