MCID: PRM014
MIFTS: 34

Periampullary Adenocarcinoma malady

Aliases & Classifications for Periampullary Adenocarcinoma

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Aliases & Descriptions for Periampullary Adenocarcinoma:

Name: Periampullary Adenocarcinoma 8 61


External Ids:

Disease Ontology8 DOID:8110
NCIt39 C27322

Summaries for Periampullary Adenocarcinoma

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MalaCards based summary: Periampullary Adenocarcinoma is related to adenocarcinoma and pancreatitis. An important gene associated with Periampullary Adenocarcinoma is CDKN1B (cyclin-dependent kinase inhibitor 1B (p27, Kip1)), and among its related pathways are Celecoxib Pathway, Pharmacodynamics and Integrins in angiogenesis. The compounds 3,3-diindolylmethane and azoxymethane have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and endothelial, and related mouse phenotypes are renal/urinary system and muscle.

Related Diseases for Periampullary Adenocarcinoma

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Diseases related to Periampullary Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.8VEGFA, CCND1, BAX, CDKN1B
2pancreatitis10.6
3neurofibromatosis, type 110.3
4neurofibromatosis10.3
5somatostatinoma10.2
6paraganglioma10.2
7blindness10.2
8gastric outlet obstruction10.2
9endotheliitis10.2
10gallbladder cancer10.1CDKN1B, BAX
11acute lymphoblastic leukemia, childhood10.1CDKN1B, BAX
12leukemia, acute promyelocytic10.1BAX, CDKN1B
13hematologic cancer10.1CDKN1B, VEGFA
14bladder cancer, somatic10.1BAX, CDKN1B
15colon adenocarcinoma10.1CDKN1B, BAX
16precursor t-cell acute lymphoblastic leukemia10.1BAX, CDKN1B
17congenital heart disease10.0VEGFA, BAX
18lung cancer10.0CCND1, VEGFA
19parathyroid adenoma10.0CDKN1B, CCND1
20glioblastoma multiforme10.0VEGFA, BAX
21esophageal cancer10.0CDKN1B, CCND1
22pancreatic cancer10.0CCND1, VEGFA
23thyroid cancer10.0CDKN1B, CCND1
24thyroid carcinoma, papillary10.0BAX, CCND1
25vascular disease10.0BAX, VEGFA
26cervical cancer, somatic9.9CDKN1B, BAX
27breast cancer9.9CDKN1B, CCND1
28kidney cancer9.9VEGFA, BAX, CDKN1B
29malignant glioma9.9VEGFA, BAX, CDKN1B
30chronic lymphocytic leukemia9.8BAX, CCND1
31laryngeal squamous cell carcinoma9.8VEGFA, CCND1, BAX
32follicular lymphoma9.8CDKN1B, BAX, CCND1
33oral cancer9.8CCND1, BAX, CDKN1B
34b-cell lymphomas9.8CDKN1B, BAX, CCND1
35myeloma9.8BAX, CCND1, VEGFA
36retinoblastoma9.8CCND1, BAX, CDKN1B
37adenoma9.8CCND1, BAX, CDKN1B
38squamous cell carcinoma, head and neck9.7CCND1, VEGFA
39burkitt lymphoma9.7CCND1, BAX, CDKN1B
40leukemia9.7CCND1, BAX, CDKN1B
41lung cancer susceptibility 39.6CDKN1B, BAX, CCND1, VEGFA
42endometrial cancer9.6VEGFA, CCND1, BAX, CDKN1B
43stomach cancer9.6VEGFA, CCND1, BAX, CDKN1B
44glioblastoma9.6CDKN1B, BAX, CCND1, VEGFA
45gastric cancer, somatic9.6CDKN1B, BAX, CCND1, VEGFA
46ovarian cancer, somatic9.6VEGFA, CCND1, BAX, CDKN1B
47hepatocellular carcinoma9.6CDKN1B, BAX, CCND1, VEGFA
48colorectal cancer9.6VEGFA, CCND1, BAX, CDKN1B
49tongue squamous cell carcinoma9.6VEGFA, CCND1, BAX, CDKN1B
50melanoma9.5VEGFA, CCND1, BAX, CDKN1B

Graphical network of the top 20 diseases related to Periampullary Adenocarcinoma:



Diseases related to periampullary adenocarcinoma

Symptoms for Periampullary Adenocarcinoma

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Drugs & Therapeutics for Periampullary Adenocarcinoma

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Drug clinical trials:

Search ClinicalTrials for Periampullary Adenocarcinoma

Search NIH Clinical Center for Periampullary Adenocarcinoma

Genetic Tests for Periampullary Adenocarcinoma

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Anatomical Context for Periampullary Adenocarcinoma

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MalaCards organs/tissues related to Periampullary Adenocarcinoma:

31
Liver, Pancreas, Endothelial

Animal Models for Periampullary Adenocarcinoma or affiliated genes

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Publications for Periampullary Adenocarcinoma

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Articles related to Periampullary Adenocarcinoma:

(show all 43)
idTitleAuthorsYear
1
A prospective, randomized, double-blind, placebo controlled trial on the efficacy of ethanol celiac plexus neurolysis in patients with operable pancreatic and periampullary adenocarcinoma. (25667135)
2015
2
Mixed periampullary adenocarcinoma and somatostatinoma with small bowel gastrointestinal stromal tumour in neurofibromatosis type 1. (25435578)
2014
3
Reduced expression of the polymeric immunoglobulin receptor in pancreatic and periampullary adenocarcinoma signifies tumour progression and poor prognosis. (25397670)
2014
4
Prognostic and treatment predictive significance of SATB1 and SATB2 expression in pancreatic and periampullary adenocarcinoma. (25323550)
2014
5
Use of a standardized diagnostic approach improves the prognostic information of histopathologic factors in pancreatic and periampullary adenocarcinoma. (24731283)
2014
6
A case of periampullary adenocarcinoma in neurofibromatosis type 1. (25436139)
2014
7
FAP related periampullary adenocarcinoma. (23792481)
2013
8
Large retroperitoneal paraganglioma concurrent with periampullary adenocarcinoma. (24523807)
2013
9
Ampullary and periampullary adenocarcinoma: new challenges in management of recurrence. (23474562)
2013
10
Resection of isolated local and metastatic recurrence in periampullary adenocarcinoma. (23601033)
2013
11
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial. (22782416)
2012
12
Prognostic significance of tumour location after adjuvant chemoradiotherapy for periampullary adenocarcinoma. (22551547)
2012
13
Adjuvant chemotherapy for resected periampullary adenocarcinoma. (23149995)
2012
14
Pancreatobiliary versus intestinal histologic type of differentiation is an independent prognostic factor in resected periampullary adenocarcinoma. (18547417)
2008
15
Results of pancreaticoduodenectomy in patients with periampullary adenocarcinoma: perineural growth more important prognostic factor than tumor localization. (18580212)
2008
16
Pancreaticoduodenectomy with extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma. (17336242)
2007
17
Resected periampullary adenocarcinoma: 5-year survivors and their 6- to 10-year follow-up. (17084719)
2006
18
Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma--part 3: update on 5-year survival. (16332474)
2005
19
Survival after attempted surgical resection and intraoperative radiation therapy for pancreatic and periampullary adenocarcinoma. (15978737)
2005
20
Neoadjuvant therapy and biliary decompression lower biliary and pancreatic juice vascular endothelial growth factor levels in patients with periampullary adenocarcinoma. (15011922)
2004
21
Recurrent disease after microscopically radical (R0) resection of periampullary adenocarcinoma in patients without adjuvant therapy. (15531230)
2004
22
Cyclin D1 and bax influence the prognosis after pancreatoduodenectomy for periampullary adenocarcinoma. (15532837)
2004
23
Standard vs. radical pancreaticoduodenectomy for periampullary adenocarcinoma: a prospective, randomized trial evaluating quality of life in pancreaticoduodenectomy survivors. (12559179)
2003
24
Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma, part 2: randomized controlled trial evaluating survival, morbidity, and mortality. (12192322)
2002
25
Survival after pancreaticoduodenectomy for periampullary adenocarcinoma: an update. (11520088)
2001
26
Preoperative platelet count predicts survival after resection of periampullary adenocarcinoma. (11677994)
2001
27
The Johns Hopkins experience with pancreaticoduodenectomy with or without extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma. (10939866)
2000
28
Intensified adjuvant combined modality therapy for resected periampullary adenocarcinoma: acceptable toxicity and suggestion of improved 1-year disease-free survival. (11072167)
2000
29
Prospective study of gastric outlet obstruction in unresectable periampullary adenocarcinoma. (10594205)
2000
30
Intensified adjuvant therapy for pancreatic and periampullary adenocarcinoma: survival results and observations regarding patterns of failure, radiotherapy dose and CA19-9 levels. (10421536)
1999
31
Implications of histological grade of tumour for the prognosis of radically resected periampullary adenocarcinoma. (10533763)
1999
32
Surgical palliation of unresectable periampullary adenocarcinoma in the 1990s. (10359359)
1999
33
Periampullary adenocarcinoma: analysis of 5-year survivors. (10561100)
1999
34
Primary nonampullary/periampullary adenocarcinoma of the duodenum. (9843337)
1998
35
Periampullary adenocarcinoma: analysis of 5-year survivors. (9637545)
1998
36
A study of forty-nine consecutive Whipple resections for periampullary adenocarcinoma. (9240943)
1997
37
Improved results for resection of periampullary adenocarcinoma. (9184871)
1996
38
Clinical behavior and prognostic factors of periampullary adenocarcinoma. (7487210)
1995
39
Pancreaticoduodenectomy for periampullary adenocarcinoma. (7952456)
1994
40
Cytogenetic characterization of a periampullary adenocarcinoma of the pancreas, its liver metastasis, and a cell line established from the metastasis and a cell line established from the metastasis in a patient with Gardner's syndrome. (8076346)
1994
41
Mixed cellular population in primary and metastatic periampullary adenocarcinoma of the duodenum: report of a case. (7633200)
1994
42
Reoperative surgery for periampullary adenocarcinoma. (1681794)
1991
43
Periampullary adenocarcinoma of the duodenum. (13253908)
1955

Variations for Periampullary Adenocarcinoma

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Expression for genes affiliated with Periampullary Adenocarcinoma

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Search GEO for disease gene expression data for Periampullary Adenocarcinoma.

Pathways for genes affiliated with Periampullary Adenocarcinoma

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Pathways related to Periampullary Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 48)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4VEGFA, CDKN1B
29.4CDKN1B, VEGFA
39.4CDKN1B, VEGFA
4
Show member pathways
AhR pathway36
9.3BAX, CDKN1B
59.3BAX, CDKN1B
69.1CCND1, CDKN1B
79.1CDKN1B, CCND1
89.1CCND1, CDKN1B
9
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
9.1CCND1, CDKN1B
109.1CDKN1B, CCND1
119.1CDKN1B, CCND1
129.1CDKN1B, CCND1
139.1CDKN1B, CCND1
14
Show member pathways
9.1CDKN1B, CCND1
159.1CDKN1B, CCND1
16
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway59
9.1CDKN1B, CCND1
17
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation59
9.1CCND1, CDKN1B
18
Show member pathways
Cell cycle ESR1 regulation of G1 S transition59
Immune response MIF JAB1 signaling59
Cell cycle Cell cycle generic schema 59
9.1CDKN1B, CCND1
19
Show member pathways
9.1CDKN1B, CCND1
20
Show member pathways
9.1CDKN1B, CCND1
21
Show member pathways
9.1CCND1, CDKN1B
22
Show member pathways
Cell cycle36
9.1CDKN1B, CCND1
23
Show member pathways
PLK2 and PLK4 events36
Polo-like kinase signaling events in the cell cycle36
9.1CDKN1B, CCND1
249.1CCND1, VEGFA
25
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway59
9.1VEGFA, CCND1
26
Show member pathways
9.0BAX, CCND1
279.0BAX, CCND1
28
Show member pathways
Signal transduction PTEN pathway59
9.0CCND1, BAX
29
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling59
Leptin signaling pathway36
9.0CCND1, BAX
30
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
9.0CCND1, BAX
31
Show member pathways
8.6CDKN1B, VEGFA, CCND1
32
Show member pathways
Signaling Pathways in Glioblastoma36
8.6CDKN1B, CCND1, VEGFA
33
Show member pathways
Integrin-mediated cell adhesion36
Focal Adhesion36
8.6CDKN1B, VEGFA, CCND1
348.6CDKN1B, CCND1, VEGFA
358.6CCND1, VEGFA, CDKN1B
36
Show member pathways
8.5CDKN1B, CCND1, BAX
37
Show member pathways
8.5CCND1, BAX, CDKN1B
38
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
8.5CDKN1B, CCND1, BAX
39
Show member pathways
Development IGF RI signaling
Immune response IL 4 signaling pathway59
Signal transduction AKT signaling59
8.5CDKN1B, BAX, CCND1
40
Show member pathways
DNA damage response36
8.5CDKN1B, CCND1, BAX
418.5CCND1, CDKN1B, BAX
42
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes59
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway59
8.5CCND1, CDKN1B, BAX
43
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I59
8.5CCND1, BAX, CDKN1B
44
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.5BAX, CDKN1B, CCND1
45
Show member pathways
8.5BAX, CDKN1B, CCND1
468.5CCND1, BAX, VEGFA
478.0VEGFA, CDKN1B, CCND1, BAX
488.0CCND1, CDKN1B, VEGFA, BAX

Compounds for genes affiliated with Periampullary Adenocarcinoma

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Compounds related to Periampullary Adenocarcinoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
13,3-diindolylmethane449.5BAX, VEGFA
2azoxymethane449.4CCND1, CDKN1B
3inostamycin449.4BAX, CCND1
4mimosine44 1110.3CCND1, CDKN1B
5ursolic acid449.3CCND1, BAX
6norcantharidin449.3CCND1, BAX
7ginsenoside449.3BAX, CCND1
8exisulind449.3CCND1, BAX
9everolimus44 50 1111.2CCND1, VEGFA
10gossypol449.2CCND1, BAX
115fluorouracil449.1VEGFA, BAX, CDKN1B
12apigenin44 2810.0CCND1, BAX
13phenethyl isothiocyanate1 4410.0CCND1, BAX
14cetuximab44 50 1111.0VEGFA, CCND1, CDKN1B
15ns 39844 6010.0VEGFA, CCND1, CDKN1B
16erlotinib44 50 1111.0VEGFA, CCND1, CDKN1B
17trastuzumab44 50 1111.0VEGFA, CCND1, CDKN1B
18gefitinib44 50 1111.0VEGFA, CCND1, CDKN1B
19imatinib44 50 1110.9VEGFA, CCND1, CDKN1B
20pd 169316448.9VEGFA, CCND1, BAX
21eb 108944 609.9CCND1, BAX, CDKN1B
22ciglitazone44 289.9BAX, CCND1, CDKN1B
23indole-3-carbinol448.9CCND1, BAX, CDKN1B
24thymidylate448.9VEGFA, CCND1, BAX
25troglitazone44 28 60 1111.9CCND1, BAX, CDKN1B
26curcumin448.8VEGFA, BAX, CCND1
27arsenite44 249.8BAX, VEGFA, CCND1
28olomoucine44 119.7CCND1, BAX
29butyrate448.7BAX, CCND1, CDKN1B
30rapamycin448.7CDKN1B, VEGFA, CCND1
31flavopiridol44 119.4CCND1, BAX, CDKN1B, VEGFA
32celecoxib44 60 28 50 24 1113.4VEGFA, CCND1, BAX, CDKN1B
33bortezomib44 50 1110.4VEGFA, CCND1, BAX, CDKN1B
34gemcitabine44 50 1110.4BAX, CCND1, VEGFA, CDKN1B
35resveratrol44 60 24 1111.4VEGFA, CCND1, CDKN1B, BAX
36egcg448.4CDKN1B, CCND1, VEGFA, BAX
37mg 13244 609.4BAX, CDKN1B, VEGFA, CCND1
38n acetylcysteine448.4CDKN1B, BAX, CCND1, VEGFA
39sb 20358044 609.4VEGFA, CCND1, BAX, CDKN1B
40tamoxifen44 50 28 1111.4VEGFA, CCND1, BAX, CDKN1B
41pd 98,059448.4BAX, CCND1, CDKN1B
42paclitaxel44 50 1110.4CCND1, VEGFA, BAX, CDKN1B
43ly294002448.4CCND1, BAX, CDKN1B, VEGFA
44doxorubicin44 50 1110.4CDKN1B, CCND1, BAX, VEGFA
45paraffin448.4CDKN1B, VEGFA, CCND1, BAX
46genistein44 28 60 1 24 1113.4CCND1, BAX, CDKN1B, VEGFA
47cisplatin44 50 60 1111.4VEGFA, CDKN1B, CCND1, BAX
48cycloheximide448.4CDKN1B, VEGFA, CCND1, BAX
49vegf448.3VEGFA, CCND1, CDKN1B, BAX
50estrogen448.3BAX, CCND1, VEGFA, CDKN1B

GO Terms for genes affiliated with Periampullary Adenocarcinoma

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Biological processes related to Periampullary Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1ovarian follicle developmentGO:00015419.5BAX, VEGFA
2response to hypoxiaGO:00016669.4CDKN1B, VEGFA
3activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.4CDKN1B, BAX
4kidney developmentGO:00018229.3VEGFA, BAX
5mammary gland alveolus developmentGO:00607499.3CCND1, VEGFA
6lactationGO:00075959.2CCND1, VEGFA
7positive regulation of protein phosphorylationGO:00019349.0CCND1, VEGFA
8G1/S transition of mitotic cell cycleGO:00000828.8CDKN1B, CCND1

Molecular functions related to Periampullary Adenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein complex bindingGO:00324039.1CDKN1B, CCND1

Sources for Periampullary Adenocarcinoma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet