MCID: PRM014
MIFTS: 37

Periampullary Adenocarcinoma malady

Summaries for Periampullary Adenocarcinoma

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32MalaCards
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MalaCards: Periampullary Adenocarcinoma is related to adenocarcinoma and duodenum adenocarcinoma. An important gene associated with Periampullary Adenocarcinoma is CDKN1B (cyclin-dependent kinase inhibitor 1B (p27, Kip1)), and among its related pathways are Integrins in angiogenesis and Celecoxib Pathway, Pharmacodynamics. The compounds 5fluorouracil and 3,3-diindolylmethane have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and endothelial, and related mouse phenotypes are nervous system and tumorigenesis.

Aliases & Classifications for Periampullary Adenocarcinoma

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8Disease Ontology, 60UMLS, 39NCIt
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Aliases & Descriptions:

periampullary adenocarcinoma 8 60


External Ids:

Disease Ontology8 DOID:8110
NCIt39 C27322

Related Diseases for Periampullary Adenocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Periampullary Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.3CDKN1B, BAX, VEGFA, CCND1
2duodenum adenocarcinoma10.3
3pancreatitis10.3
4gastric adenocarcinoma10.1
5pancreas adenocarcinoma10.1
6papilloma10.0CDKN1B
7hyperparathyroidism10.0CDKN1B
8pituitary adenoma10.0CDKN1B
9endometriosis10.0VEGFA
10cholangiocarcinoma10.0CDKN1B
11tuberous sclerosis10.0CDKN1B
12pituitary tumors10.0CDKN1B
13retinal ischemia10.0VEGFA
14hemangioblastoma10.0VEGFA
15osteosarcoma10.0BAX
16von hippel-lindau disease10.0VEGFA
17myeloid leukemia10.0BAX
18cervical adenocarcinoma10.0CDKN1B
19brain cancer10.0BAX
20anaplastic astrocytoma10.0VEGFA
21ductal carcinoma in situ10.0CCND1
22laryngeal benign neoplasm10.0CCND1
23renal clear cell carcinoma10.0VEGFA
24macroglobulinemia, waldenstrom, somatic10.0CCND1
25multiple myeloma10.0CCND1
26gastrointestinal system disease10.0BAX
27cervical squamous cell carcinoma10.0CDKN1B
28malt lymphoma10.0CCND1
29astrocytoma10.0VEGFA, CDKN1B
30bladder carcinoma10.0BAX, CDKN1B
31colon adenocarcinoma10.0CDKN1B, BAX
32cervical cancer10.0CDKN1B, BAX
33ischemia10.0BAX, VEGFA
34gallbladder cancer10.0BAX, CDKN1B
35acute lymphoblastic leukemia, childhood10.0CDKN1B, BAX
36thyroid cancer10.0CDKN1B, CCND1
37acute promyelocytic leukemia10.0BAX, CDKN1B
38parathyroid adenoma10.0CDKN1B, CCND1
39esophageal squamous cell carcinoma10.0BAX, CCND1
40esophageal cancer10.0CDKN1B, CCND1
41hematologic cancer10.0CDKN1B, VEGFA
42glioblastoma multiforme10.0BAX, VEGFA
43lung cancer10.0VEGFA, CCND1
44papillary thyroid carcinoma10.0CCND1, BAX
45pancreatic cancer10.0VEGFA, CCND1
46precursor t-cell acute lymphoblastic leukemia10.0BAX, CDKN1B
47kidney cancer10.0VEGFA, BAX, CDKN1B
48malignant glioma10.0CDKN1B, BAX, VEGFA
49congenital heart defect10.0VEGFA, BAX
50laryngeal squamous cell carcinoma10.0CCND1, VEGFA, BAX

Graphical network of the top 20 diseases related to Periampullary Adenocarcinoma:



Diseases related to periampullary adenocarcinoma

Clinical Features for Periampullary Adenocarcinoma

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Drugs & Therapeutics for Periampullary Adenocarcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Periampullary Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Periampullary Adenocarcinoma

Search NIH Clinical Center for Periampullary Adenocarcinoma

Search CenterWatch for Periampullary Adenocarcinoma

Genetic Tests for Periampullary Adenocarcinoma

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Anatomical Context for Periampullary Adenocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Periampullary Adenocarcinoma:

32
Pancreas, Liver, Endothelial

Animal Models for Periampullary Adenocarcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Periampullary Adenocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036319.6BAX
2MP:00020068.6CDKN1B, VEGFA, CCND1
3MP:00053888.2CDKN1B, BAX, VEGFA, CCND1
4MP:00053798.1CCND1, VEGFA, BAX, CDKN1B
5MP:00053898.1CDKN1B, BAX, VEGFA, CCND1
6MP:00053978.1CCND1, VEGFA, BAX, CDKN1B
7MP:00053868.0CDKN1B, BAX, VEGFA, CCND1
8MP:00053877.9CCND1, VEGFA, BAX, CDKN1B

Publications for Periampullary Adenocarcinoma

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50PubMed
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Articles related to Periampullary Adenocarcinoma:

(show all 39)
idTitleAuthorsYear
1
Periampullary lymphoma masquerading as adenocarcinoma. (24426719)
2013
2
FAP related periampullary adenocarcinoma. (23792481)
2013
3
Ampullary and periampullary adenocarcinoma: new challenges in management of recurrence. (23474562)
2013
4
Resection of isolated local and metastatic recurrence in periampullary adenocarcinoma. (23601033)
2013
5
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial. (22782416)
2012
6
Prognostic significance of tumour location after adjuvant chemoradiotherapy for periampullary adenocarcinoma. (22551547)
2012
7
Adjuvant chemotherapy for resected periampullary adenocarcinoma. (23149995)
2012
8
Pancreatobiliary versus intestinal histologic type of differentiation is an independent prognostic factor in resected periampullary adenocarcinoma. (18547417)
2008
9
Results of pancreaticoduodenectomy in patients with periampullary adenocarcinoma: perineural growth more important prognostic factor than tumor localization. (18580212)
2008
10
Pancreaticoduodenectomy with extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma. (17336242)
2007
11
Resected periampullary adenocarcinoma: 5-year survivors and their 6- to 10-year follow-up. (17084719)
2006
12
Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma--part 3: update on 5-year survival. (16332474)
2005
13
Homozygous deletion of the MTAP gene in invasive adenocarcinoma of the pancreas and in periampullary cancer: a potential new target for therapy. (15662124)
2005
14
Survival after attempted surgical resection and intraoperative radiation therapy for pancreatic and periampullary adenocarcinoma. (15978737)
2005
15
Neoadjuvant therapy and biliary decompression lower biliary and pancreatic juice vascular endothelial growth factor levels in patients with periampullary adenocarcinoma. (15011922)
2004
16
Recurrent disease after microscopically radical (R0) resection of periampullary adenocarcinoma in patients without adjuvant therapy. (15531230)
2004
17
Cyclin D1 and bax influence the prognosis after pancreatoduodenectomy for periampullary adenocarcinoma. (15532837)
2004
18
Standard vs. radical pancreaticoduodenectomy for periampullary adenocarcinoma: a prospective, randomized trial evaluating quality of life in pancreaticoduodenectomy survivors. (12559179)
2003
19
Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma, part 2: randomized controlled trial evaluating survival, morbidity, and mortality. (12192322)
2002
20
Periampullary adenomas and adenocarcinomas in familial adenomatous polyposis: cumulative risks and APC gene mutations. (11677205)
2001
21
Survival after pancreaticoduodenectomy for periampullary adenocarcinoma: an update. (11520088)
2001
22
Preoperative platelet count predicts survival after resection of periampullary adenocarcinoma. (11677994)
2001
23
The Johns Hopkins experience with pancreaticoduodenectomy with or without extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma. (10939866)
2000
24
Intensified adjuvant combined modality therapy for resected periampullary adenocarcinoma: acceptable toxicity and suggestion of improved 1-year disease-free survival. (11072167)
2000
25
Prospective study of gastric outlet obstruction in unresectable periampullary adenocarcinoma. (10594205)
2000
26
Intensified adjuvant therapy for pancreatic and periampullary adenocarcinoma: survival results and observations regarding patterns of failure, radiotherapy dose and CA19-9 levels. (10421536)
1999
27
Implications of histological grade of tumour for the prognosis of radically resected periampullary adenocarcinoma. (10533763)
1999
28
Surgical palliation of unresectable periampullary adenocarcinoma in the 1990s. (10359359)
1999
29
Periampullary adenocarcinoma: analysis of 5-year survivors. (10561100)
1999
30
Primary nonampullary/periampullary adenocarcinoma of the duodenum. (9843337)
1998
31
Periampullary adenocarcinoma: analysis of 5-year survivors. (9637545)
1998
32
A study of forty-nine consecutive Whipple resections for periampullary adenocarcinoma. (9240943)
1997
33
Improved results for resection of periampullary adenocarcinoma. (9184871)
1996
34
Clinical behavior and prognostic factors of periampullary adenocarcinoma. (7487210)
1995
35
Pancreaticoduodenectomy for periampullary adenocarcinoma. (7952456)
1994
36
Cytogenetic characterization of a periampullary adenocarcinoma of the pancreas, its liver metastasis, and a cell line established from the metastasis and a cell line established from the metastasis in a patient with Gardner's syndrome. (8076346)
1994
37
Mixed cellular population in primary and metastatic periampullary adenocarcinoma of the duodenum: report of a case. (7633200)
1994
38
Reoperative surgery for periampullary adenocarcinoma. (1681794)
1991
39
Periampullary adenocarcinoma of the duodenum. (13253908)
1955

Genetic Variations for Periampullary Adenocarcinoma

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Expression for genes affiliated with Periampullary Adenocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Periampullary Adenocarcinoma

Search GEO for disease gene expression data for Periampullary Adenocarcinoma.

Pathways for genes affiliated with Periampullary Adenocarcinoma

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Sources:
37NCBI BioSystems Database, 49PharmGKB, 29KEGG, 51QIAGEN, 53Reactome, 12EMD Millipore, 55SinoBiological, 52R&D Systems
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Pathways related to Periampullary Adenocarcinoma according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CDKN1B, VEGFA
29.4CDKN1B, VEGFA
39.4VEGFA, CDKN1B
49.3BAX, CDKN1B
59.1CCND1, CDKN1B
69.1CCND1, CDKN1B
79.1CDKN1B, CCND1
89.1CCND1, CDKN1B
9
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9.1CDKN1B, CCND1
109.1CDKN1B, CCND1
11
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9.1CDKN1B, CCND1
129.1CDKN1B, CCND1
13
Development Thrombopoetin signaling via JAK-STAT pathway
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9.1CDKN1B, CCND1
149.1CDKN1B, CCND1
15
Development Ligand-dependent activation of the ESR1/AP-1 pathway
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9.1CCND1, VEGFA
16
Immune response Oncostatin M signaling via JAK-Stat in human cells
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9.1VEGFA, CCND1
17
Hide members
9.0BAX, CCND1
18
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9.0CCND1, BAX
19
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9.0BAX, CCND1
208.6CCND1, VEGFA, CDKN1B
21
Hide members
8.6CCND1, VEGFA, CDKN1B
22
Hide members
8.6CCND1, VEGFA, CDKN1B
238.6CDKN1B, VEGFA, CCND1
24
Hide members
8.5CCND1, BAX, CDKN1B
25
Hide members
8.5CCND1, BAX, CDKN1B
26
Hide members
8.5CDKN1B, BAX, CCND1
27
Hide members
8.5CCND1, BAX, CDKN1B
28
Hide members
8.5CDKN1B, BAX, CCND1
29
Hide members
8.5CDKN1B, BAX, CCND1
30
Hide members
8.5CCND1, BAX, CDKN1B
318.5CCND1, BAX, CDKN1B
32
Hide members
8.5CDKN1B, BAX, CCND1
338.5CCND1, VEGFA, BAX
348.0CDKN1B, BAX, VEGFA, CCND1
358.0CDKN1B, BAX, VEGFA, CCND1

Compounds for genes affiliated with Periampullary Adenocarcinoma

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 24HMDB
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Compounds related to Periampullary Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
15fluorouracil4410.1BAX
23,3-diindolylmethane449.5BAX, VEGFA
3azoxymethane449.5CDKN1B, CCND1
4inostamycin449.4CCND1, BAX
5everolimus49 44 1111.4CCND1, VEGFA
6mimosine44 1110.4CDKN1B, CCND1
7ursolic acid449.4BAX, CCND1
8norcantharidin449.3CCND1, BAX
9ginsenoside449.3CCND1, BAX
10exisulind449.3CCND1, BAX
11gossypol449.3CCND1, BAX
12apigenin44 2810.2BAX, CCND1
13olomoucine44 1110.2BAX, CCND1
14phenethyl isothiocyanate44 210.1CCND1, BAX
15cetuximab44 49 1111.0VEGFA, CCND1, CDKN1B
16sulindac sulfide449.0BAX, CCND1
17ns 39844 5910.0CCND1, VEGFA, CDKN1B
18erlotinib44 49 1111.0CCND1, VEGFA, CDKN1B
19trastuzumab44 49 1111.0CCND1, VEGFA, CDKN1B
20gefitinib44 49 1111.0VEGFA, CCND1, CDKN1B
21imatinib44 49 1111.0CDKN1B, VEGFA, CCND1
22pd 169316448.9CCND1, VEGFA, BAX
23eb 108944 599.9BAX, CDKN1B, CCND1
24ciglitazone44 289.9CCND1, CDKN1B, BAX
25indole-3-carbinol448.9CDKN1B, BAX, CCND1
26thymidylate448.9VEGFA, CCND1, BAX
27troglitazone44 28 59 1111.9CCND1, BAX, CDKN1B
28curcumin448.8BAX, CCND1, VEGFA
29arsenite44 249.8CCND1, VEGFA, BAX
30actinomycin d448.8CDKN1B, BAX, VEGFA
31rapamycin448.7VEGFA, CDKN1B, CCND1
32flavopiridol44 119.4VEGFA, BAX, CCND1, CDKN1B
33celecoxib44 59 28 49 11 2413.4VEGFA, BAX, CDKN1B, CCND1
34bortezomib44 119.4BAX, VEGFA, CCND1, CDKN1B
35gemcitabine44 49 1110.4CDKN1B, BAX, VEGFA, CCND1
36mg 13244 599.4VEGFA, CCND1, BAX, CDKN1B
37n acetylcysteine448.4CCND1, VEGFA, BAX, CDKN1B
38sb 20358044 599.4CCND1, VEGFA, CDKN1B, BAX
39tamoxifen44 49 28 1111.4CCND1, BAX, CDKN1B, VEGFA
40pd 98,059448.4CDKN1B, BAX, CCND1
41paclitaxel44 49 1110.4BAX, VEGFA, CCND1, CDKN1B
42ly294002448.4CDKN1B, BAX, VEGFA, CCND1
43doxorubicin44 49 1110.4CCND1, VEGFA, BAX, CDKN1B
44paraffin448.4CCND1, VEGFA, CDKN1B, BAX
45genistein44 28 59 2 11 2413.4CCND1, VEGFA, CDKN1B, BAX
46cisplatin44 49 59 1111.4VEGFA, CDKN1B, CCND1, BAX
47cycloheximide448.4VEGFA, CCND1, BAX, CDKN1B
48vegf448.3BAX, CCND1, VEGFA, CDKN1B
49estrogen448.3BAX, VEGFA, CCND1, CDKN1B
50wortmannin448.2CDKN1B, CCND1, BAX

GO Terms for genes affiliated with Periampullary Adenocarcinoma

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16Gene Ontology
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Biological processes related to Periampullary Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ovarian follicle developmentGO:0015419.3BAX, VEGFA
2mammary gland alveolus developmentGO:0607499.2VEGFA, CCND1
3activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.2BAX, CDKN1B
4lactationGO:0075959.2VEGFA, CCND1
5positive regulation of protein phosphorylationGO:0019349.1VEGFA, CCND1
6kidney developmentGO:0018229.0BAX, VEGFA

Products for genes affiliated with Periampullary Adenocarcinoma

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Sources for Periampullary Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet