MCID: PRM014
MIFTS: 40

Periampullary Adenocarcinoma malady

Cancer diseases category
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Summaries for Periampullary Adenocarcinoma

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33MalaCards
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MalaCards: Periampullary Adenocarcinoma is related to adenocarcinoma and pancreatitis. An important gene associated with Periampullary Adenocarcinoma is CDKN1B (cyclin-dependent kinase inhibitor 1B (p27, Kip1)), and among its related pathways are Celecoxib Pathway, Pharmacodynamics and Integrins in angiogenesis. The compounds 3,3-diindolylmethane and azoxymethane have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and endothelial, and related mouse phenotypes are renal/urinary system and muscle.

Aliases & Classifications for Periampullary Adenocarcinoma

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8Disease Ontology, 62UMLS, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

periampullary adenocarcinoma 8 62


External Ids:

Disease Ontology8 DOID:8110
NCIt40 C27322

Related Diseases for Periampullary Adenocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Periampullary Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.2VEGFA, CCND1, BAX, CDKN1B
2pancreatitis10.4
3gastric outlet obstruction10.1
4endotheliitis10.1
5gallbladder cancer10.0CDKN1B, BAX
6acute lymphoblastic leukemia, childhood10.0BAX, CDKN1B
7acute promyelocytic leukemia10.0BAX, CDKN1B
8hematologic cancer10.0VEGFA, CDKN1B
9bladder carcinoma10.0BAX, CDKN1B
10colon adenocarcinoma10.0BAX, CDKN1B
11precursor t-cell acute lymphoblastic leukemia10.0BAX, CDKN1B
12congenital heart disease10.0BAX, VEGFA
13lung cancer10.0CCND1, VEGFA
14parathyroid adenoma10.0CCND1, CDKN1B
15glioblastoma multiforme10.0VEGFA, BAX
16esophageal cancer10.0CDKN1B, CCND1
17esophageal squamous cell carcinoma10.0BAX, CCND1
18pancreatic cancer10.0VEGFA, CCND1
19thyroid cancer10.0CDKN1B, CCND1
20papillary thyroid carcinoma10.0BAX, CCND1
21vascular disease10.0VEGFA, BAX
22cervical cancer10.0BAX, CDKN1B
23breast cancer10.0CCND1, CDKN1B
24kidney cancer10.0CDKN1B, VEGFA, BAX
25malignant glioma10.0CDKN1B, VEGFA, BAX
26chronic lymphocytic leukemia10.0CCND1, BAX
27laryngeal squamous cell carcinoma10.0BAX, VEGFA, CCND1
28follicular lymphoma10.0CCND1, BAX, CDKN1B
29oral cancer10.0CCND1, BAX, CDKN1B
30b-cell chronic lymphocytic leukemia9.9CDKN1B, CCND1, BAX
31non-small cell lung carcinoma9.9CCND1, VEGFA, BAX
32b-cell lymphomas9.9CCND1, CDKN1B, BAX
33myeloma9.9BAX, CCND1, VEGFA
34retinoblastoma9.9CDKN1B, CCND1, BAX
35adenoma9.9CCND1, BAX, CDKN1B
36squamous cell carcinoma of the head and neck9.9VEGFA, CCND1
37burkitt's lymphoma9.9CCND1, CDKN1B, BAX
38leukemia9.9BAX, CCND1, CDKN1B
39lung adenocarcinoma9.9CCND1, BAX, CDKN1B, VEGFA
40endometrial carcinoma9.9VEGFA, CCND1, BAX, CDKN1B
41stomach cancer9.9CCND1, VEGFA, CDKN1B, BAX
42ovarian cancer9.9BAX, CCND1, VEGFA, CDKN1B
43colon cancer9.9BAX, VEGFA, CCND1, CDKN1B
44hepatocellular carcinoma9.9BAX, CCND1, VEGFA, CDKN1B
45colorectal cancer9.9CCND1, CDKN1B, BAX, VEGFA
46tongue squamous cell carcinoma9.9VEGFA, CCND1, BAX, CDKN1B
47melanoma9.9BAX, CCND1, VEGFA, CDKN1B
48prostate cancer9.9CDKN1B, BAX, VEGFA, CCND1

Graphical network of the top 20 diseases related to Periampullary Adenocarcinoma:



Diseases related to periampullary adenocarcinoma

Symptoms for Periampullary Adenocarcinoma

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Drugs & Therapeutics for Periampullary Adenocarcinoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Periampullary Adenocarcinoma

Search NIH Clinical Center for Periampullary Adenocarcinoma

Genetic Tests for Periampullary Adenocarcinoma

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Anatomical Context for Periampullary Adenocarcinoma

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33MalaCards
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MalaCards organs/tissues related to Periampullary Adenocarcinoma:

33
Liver, Pancreas, Endothelial

Animal Models for Periampullary Adenocarcinoma or affiliated genes

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Sources:
37MGI
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Publications for Periampullary Adenocarcinoma

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52PubMed
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Articles related to Periampullary Adenocarcinoma:

(show all 36)
idTitleAuthorsYear
1
FAP related periampullary adenocarcinoma. (23792481)
2013
2
Ampullary and periampullary adenocarcinoma: new challenges in management of recurrence. (23474562)
2013
3
Resection of isolated local and metastatic recurrence in periampullary adenocarcinoma. (23601033)
2013
4
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial. (22782416)
2012
5
Prognostic significance of tumour location after adjuvant chemoradiotherapy for periampullary adenocarcinoma. (22551547)
2012
6
Adjuvant chemotherapy for resected periampullary adenocarcinoma. (23149995)
2012
7
Pancreatobiliary versus intestinal histologic type of differentiation is an independent prognostic factor in resected periampullary adenocarcinoma. (18547417)
2008
8
Results of pancreaticoduodenectomy in patients with periampullary adenocarcinoma: perineural growth more important prognostic factor than tumor localization. (18580212)
2008
9
Pancreaticoduodenectomy with extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma. (17336242)
2007
10
Resected periampullary adenocarcinoma: 5-year survivors and their 6- to 10-year follow-up. (17084719)
2006
11
Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma--part 3: update on 5-year survival. (16332474)
2005
12
Survival after attempted surgical resection and intraoperative radiation therapy for pancreatic and periampullary adenocarcinoma. (15978737)
2005
13
Neoadjuvant therapy and biliary decompression lower biliary and pancreatic juice vascular endothelial growth factor levels in patients with periampullary adenocarcinoma. (15011922)
2004
14
Recurrent disease after microscopically radical (R0) resection of periampullary adenocarcinoma in patients without adjuvant therapy. (15531230)
2004
15
Cyclin D1 and bax influence the prognosis after pancreatoduodenectomy for periampullary adenocarcinoma. (15532837)
2004
16
Standard vs. radical pancreaticoduodenectomy for periampullary adenocarcinoma: a prospective, randomized trial evaluating quality of life in pancreaticoduodenectomy survivors. (12559179)
2003
17
Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma, part 2: randomized controlled trial evaluating survival, morbidity, and mortality. (12192322)
2002
18
Survival after pancreaticoduodenectomy for periampullary adenocarcinoma: an update. (11520088)
2001
19
Preoperative platelet count predicts survival after resection of periampullary adenocarcinoma. (11677994)
2001
20
The Johns Hopkins experience with pancreaticoduodenectomy with or without extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma. (10939866)
2000
21
Intensified adjuvant combined modality therapy for resected periampullary adenocarcinoma: acceptable toxicity and suggestion of improved 1-year disease-free survival. (11072167)
2000
22
Prospective study of gastric outlet obstruction in unresectable periampullary adenocarcinoma. (10594205)
2000
23
Intensified adjuvant therapy for pancreatic and periampullary adenocarcinoma: survival results and observations regarding patterns of failure, radiotherapy dose and CA19-9 levels. (10421536)
1999
24
Implications of histological grade of tumour for the prognosis of radically resected periampullary adenocarcinoma. (10533763)
1999
25
Surgical palliation of unresectable periampullary adenocarcinoma in the 1990s. (10359359)
1999
26
Periampullary adenocarcinoma: analysis of 5-year survivors. (10561100)
1999
27
Primary nonampullary/periampullary adenocarcinoma of the duodenum. (9843337)
1998
28
Periampullary adenocarcinoma: analysis of 5-year survivors. (9637545)
1998
29
A study of forty-nine consecutive Whipple resections for periampullary adenocarcinoma. (9240943)
1997
30
Improved results for resection of periampullary adenocarcinoma. (9184871)
1996
31
Clinical behavior and prognostic factors of periampullary adenocarcinoma. (7487210)
1995
32
Pancreaticoduodenectomy for periampullary adenocarcinoma. (7952456)
1994
33
Cytogenetic characterization of a periampullary adenocarcinoma of the pancreas, its liver metastasis, and a cell line established from the metastasis and a cell line established from the metastasis in a patient with Gardner's syndrome. (8076346)
1994
34
Mixed cellular population in primary and metastatic periampullary adenocarcinoma of the duodenum: report of a case. (7633200)
1994
35
Reoperative surgery for periampullary adenocarcinoma. (1681794)
1991
36
Periampullary adenocarcinoma of the duodenum. (13253908)
1955

Variations for Periampullary Adenocarcinoma

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Expression for genes affiliated with Periampullary Adenocarcinoma

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Periampullary Adenocarcinoma

Search GEO for disease gene expression data for Periampullary Adenocarcinoma.

Pathways for genes affiliated with Periampullary Adenocarcinoma

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Sources:
50PathCards, 51PharmGKB, 38NCBI BioSystems Database, 30KEGG, 53QIAGEN, 55Reactome, 5Cell Signaling Technology, 60Thomson Reuters, 57SinoBiological, 12EMD Millipore, 54R&D Systems
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Pathways related to Periampullary Adenocarcinoma according to GeneCards/GeneDecks:

(show all 48)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CDKN1B, VEGFA
29.4VEGFA, CDKN1B
39.4CDKN1B, VEGFA
4
Show member pathways
AhR pathway38
9.3CDKN1B, BAX
59.3CDKN1B, BAX
69.1CDKN1B, CCND1
79.1CDKN1B, CCND1
89.1CCND1, CDKN1B
9
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
9.1CDKN1B, CCND1
109.1CDKN1B, CCND1
119.1CDKN1B, CCND1
129.1CDKN1B, CCND1
139.1CCND1, CDKN1B
14
Show member pathways
9.1CCND1, CDKN1B
159.1CDKN1B, CCND1
16
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.1CDKN1B, CCND1
17
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.1CDKN1B, CCND1
18
Show member pathways
Cell cycle ESR1 regulation of G1 S transition60
Immune response MIF JAB1 signaling60
Cell cycle Cell cycle generic schema 60
9.1CCND1, CDKN1B
19
Show member pathways
9.1CCND1, CDKN1B
20
Show member pathways
9.1CDKN1B, CCND1
21
Show member pathways
9.1CDKN1B, CCND1
22
Show member pathways
Cell cycle38
9.1CDKN1B, CCND1
23
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
9.1CCND1, CDKN1B
249.1CCND1, VEGFA
25
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
9.1CCND1, VEGFA
26
Show member pathways
9.0BAX, CCND1
279.0BAX, CCND1
28
Show member pathways
Signal transduction PTEN pathway60
9.0BAX, CCND1
29
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
9.0CCND1, BAX
30
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
9.0BAX, CCND1
31
Show member pathways
8.6CDKN1B, CCND1, VEGFA
32
Show member pathways
Signaling Pathways in Glioblastoma38
8.6CDKN1B, CCND1, VEGFA
33
Show member pathways
Integrin-mediated cell adhesion38
Focal Adhesion38
8.6VEGFA, CCND1, CDKN1B
348.6CDKN1B, CCND1, VEGFA
358.6CDKN1B, CCND1, VEGFA
36
Show member pathways
8.5CDKN1B, BAX, CCND1
37
Show member pathways
8.5CCND1, BAX, CDKN1B
38
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
8.5CDKN1B, BAX, CCND1
39
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
8.5CCND1, BAX, CDKN1B
40
Show member pathways
DNA damage response38
8.5CDKN1B, BAX, CCND1
418.5CCND1, BAX, CDKN1B
42
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
8.5CCND1, BAX, CDKN1B
43
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
8.5CDKN1B, BAX, CCND1
44
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.5CDKN1B, BAX, CCND1
45
Show member pathways
8.5CCND1, BAX, CDKN1B
468.5BAX, CCND1, VEGFA
478.0VEGFA, CCND1, BAX, CDKN1B
488.0CDKN1B, BAX, CCND1, VEGFA

Compounds for genes affiliated with Periampullary Adenocarcinoma

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 3BitterDB, 61Tocris Bioscience, 24HMDB
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Compounds related to Periampullary Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
13,3-diindolylmethane459.5BAX, VEGFA
2azoxymethane459.4CCND1, CDKN1B
3inostamycin459.4BAX, CCND1
4mimosine45 1110.3CCND1, CDKN1B
5ursolic acid459.3CCND1, BAX
6norcantharidin459.3CCND1, BAX
7ginsenoside459.3BAX, CCND1
8exisulind459.3CCND1, BAX
9everolimus45 51 1111.2CCND1, VEGFA
10gossypol459.2CCND1, BAX
115fluorouracil459.1VEGFA, BAX, CDKN1B
12apigenin45 2910.0CCND1, BAX
13phenethyl isothiocyanate3 4510.0CCND1, BAX
14cetuximab45 51 1111.0VEGFA, CCND1, CDKN1B
15ns 39845 6110.0VEGFA, CCND1, CDKN1B
16erlotinib45 51 1111.0VEGFA, CCND1, CDKN1B
17trastuzumab45 51 1111.0VEGFA, CCND1, CDKN1B
18gefitinib45 51 1111.0VEGFA, CCND1, CDKN1B
19imatinib45 51 1110.9VEGFA, CCND1, CDKN1B
20pd 169316458.9VEGFA, CCND1, BAX
21eb 108945 619.9CCND1, BAX, CDKN1B
22ciglitazone45 299.9BAX, CCND1, CDKN1B
23indole-3-carbinol458.9CCND1, BAX, CDKN1B
24thymidylate458.9VEGFA, CCND1, BAX
25troglitazone45 29 61 1111.9CCND1, BAX, CDKN1B
26curcumin458.8VEGFA, BAX, CCND1
27arsenite45 249.8BAX, VEGFA, CCND1
28olomoucine45 119.7CCND1, BAX
29butyrate458.7BAX, CCND1, CDKN1B
30rapamycin458.7CDKN1B, VEGFA, CCND1
31flavopiridol45 119.4CCND1, BAX, CDKN1B, VEGFA
32celecoxib45 61 29 51 24 1113.4VEGFA, CCND1, BAX, CDKN1B
33bortezomib45 51 1110.4VEGFA, CCND1, BAX, CDKN1B
34gemcitabine45 51 1110.4BAX, CCND1, VEGFA, CDKN1B
35resveratrol45 61 24 1111.4VEGFA, CCND1, CDKN1B, BAX
36egcg458.4CDKN1B, CCND1, VEGFA, BAX
37mg 13245 619.4BAX, CDKN1B, VEGFA, CCND1
38n acetylcysteine458.4CDKN1B, BAX, CCND1, VEGFA
39sb 20358045 619.4VEGFA, CCND1, BAX, CDKN1B
40tamoxifen45 51 29 1111.4VEGFA, CCND1, BAX, CDKN1B
41pd 98,059458.4BAX, CCND1, CDKN1B
42paclitaxel45 51 1110.4CCND1, VEGFA, BAX, CDKN1B
43ly294002458.4CCND1, BAX, CDKN1B, VEGFA
44doxorubicin45 51 1110.4CDKN1B, CCND1, BAX, VEGFA
45paraffin458.4CDKN1B, VEGFA, CCND1, BAX
46genistein45 29 61 3 24 1113.4CCND1, BAX, CDKN1B, VEGFA
47cisplatin45 51 61 1111.4VEGFA, CDKN1B, CCND1, BAX
48cycloheximide458.4CDKN1B, VEGFA, CCND1, BAX
49vegf458.3VEGFA, CCND1, CDKN1B, BAX
50estrogen458.3BAX, CCND1, VEGFA, CDKN1B

GO Terms for genes affiliated with Periampullary Adenocarcinoma

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Sources:
16Gene Ontology
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Biological processes related to Periampullary Adenocarcinoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1ovarian follicle developmentGO:0015419.5BAX, VEGFA
2response to hypoxiaGO:0016669.4CDKN1B, VEGFA
3activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.4CDKN1B, BAX
4kidney developmentGO:0018229.3VEGFA, BAX
5mammary gland alveolus developmentGO:0607499.3CCND1, VEGFA
6lactationGO:0075959.2CCND1, VEGFA
7positive regulation of protein phosphorylationGO:0019349.0CCND1, VEGFA
8G1/S transition of mitotic cell cycleGO:0000828.8CDKN1B, CCND1

Molecular functions related to Periampullary Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complex bindingGO:0324039.1CDKN1B, CCND1

Products for genes affiliated with Periampullary Adenocarcinoma

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Sources for Periampullary Adenocarcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet