MCID: PRM190
MIFTS: 25

Periampullary Adenoma

Categories: Cancer diseases

Aliases & Classifications for Periampullary Adenoma

MalaCards integrated aliases for Periampullary Adenoma:

Name: Periampullary Adenoma 12 28 14

Classifications:



External Ids:

Disease Ontology 12 DOID:0050849

Summaries for Periampullary Adenoma

MalaCards based summary : Periampullary Adenoma is related to adenoma and hyperplastic polyposis syndrome. An important gene associated with Periampullary Adenoma is APC (APC, WNT Signaling Pathway Regulator), and among its related pathways/superpathways are Regulation of actin cytoskeleton and MicroRNAs in cancer. Related phenotypes are behavior/neurological and neoplasm

Related Diseases for Periampullary Adenoma

Diseases related to Periampullary Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 adenoma 30.1 APC KRAS SST
2 hyperplastic polyposis syndrome 10.2 APC KRAS
3 mutyh-associated polyposis 10.2 APC KRAS
4 villous adenoma 10.2 KRAS SST
5 colon adenoma 10.1 APC KRAS
6 small intestine cancer 10.1 KRAS SST
7 sigmoid neoplasm 10.1 HRAS KRAS
8 apocrine adenoma 10.1 HRAS KRAS
9 schimmelpenning-feuerstein-mims syndrome 10.1 HRAS KRAS
10 paronychia 10.1 HRAS KRAS
11 bile duct cysts 10.1 HRAS KRAS
12 aggressive digital papillary adenocarcinoma 10.1 HRAS KRAS
13 secondary hypertrophic osteoarthropathy 10.0 HRAS KRAS
14 nasal cavity adenocarcinoma 10.0 HRAS KRAS
15 nevus, epidermal 10.0 HRAS KRAS
16 lung adenoid cystic carcinoma 10.0 HRAS KRAS
17 ovary serous adenocarcinoma 10.0 HRAS KRAS
18 ovarian cystadenocarcinoma 10.0 HRAS KRAS
19 biliary papillomatosis 10.0 HRAS KRAS
20 pulmonic stenosis 10.0 HRAS KRAS
21 acneiform dermatitis 10.0 HRAS KRAS
22 ovary adenocarcinoma 10.0 HRAS KRAS
23 mccune-albright syndrome 10.0 APC SST
24 mixed cell type cancer 10.0 HRAS KRAS
25 adenosquamous cell lung carcinoma 10.0 HRAS KRAS
26 adenosquamous pancreas carcinoma 10.0 HRAS KRAS
27 cecum adenocarcinoma 10.0 HRAS KRAS
28 familial adenomatous polyposis 10.0
29 core binding factor acute myeloid leukemia 10.0 HRAS KRAS
30 biliary tract neoplasm 10.0 HRAS KRAS
31 liver angiosarcoma 10.0 HRAS KRAS
32 lacrimal gland adenocarcinoma 10.0 HRAS KRAS
33 fibrous dysplasia 10.0 APC SST
34 costello syndrome 10.0 HRAS KRAS
35 bile duct adenocarcinoma 9.9 HRAS KRAS
36 gastrointestinal system benign neoplasm 9.9 HRAS KRAS
37 cyclosporiasis 9.9 GGT1 GGT2
38 exanthem 9.9 HRAS KRAS
39 algoneurodystrophy 9.9 GGT1 GGT2
40 hepatic tuberculosis 9.9 GGT1 GGT2
41 cardiofaciocutaneous syndrome 1 9.9 HRAS KRAS
42 malignant ovarian surface epithelial-stromal neoplasm 9.9 HRAS KRAS
43 ovary epithelial cancer 9.9 HRAS KRAS
44 adenocarcinoma 9.8
45 pancreatitis 9.8
46 lung benign neoplasm 9.8 HRAS KRAS
47 granulomatous hepatitis 9.8 GGT1 GGT2
48 intestinal benign neoplasm 9.8 APC HRAS KRAS
49 colonic benign neoplasm 9.8 APC HRAS KRAS
50 bile duct disease 9.8 GGT1 GGT2

Graphical network of the top 20 diseases related to Periampullary Adenoma:



Diseases related to Periampullary Adenoma

Symptoms & Phenotypes for Periampullary Adenoma

MGI Mouse Phenotypes related to Periampullary Adenoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.63 APC GGT1 HRAS KRAS NTHL1 SST
2 neoplasm MP:0002006 9.26 APC HRAS KRAS NTHL1
3 skeleton MP:0005390 9.02 SST APC GGT1 HRAS KRAS

Drugs & Therapeutics for Periampullary Adenoma

Search Clinical Trials , NIH Clinical Center for Periampullary Adenoma

Genetic Tests for Periampullary Adenoma

Genetic tests related to Periampullary Adenoma:

# Genetic test Affiliating Genes
1 Periampullary Adenoma 28

Anatomical Context for Periampullary Adenoma

Publications for Periampullary Adenoma

Articles related to Periampullary Adenoma:

# Title Authors Year
1
Magnified endoscopic observation using narrow-band imaging of periampullary adenoma in a patient with familial adenomatous polyposis. ( 19946237 )
2009
2
Periampullary adenomas and adenocarcinomas in familial adenomatous polyposis: cumulative risks and APC gene mutations. ( 11677205 )
2001
3
Management of periampullary adenoma. ( 9892786 )
1998
4
Endoscopic evaluation and therapy of periampullary adenoma. ( 6837547 )
1983
5
Periampullary adenoma causing pancreatitis. ( 6790055 )
1981

Variations for Periampullary Adenoma

ClinVar genetic disease variations for Periampullary Adenoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 APC NM_000038.5(APC): c.4393_4394delAG (p.Ser1465Trpfs) deletion Pathogenic rs387906234 GRCh37 Chromosome 5, 112175684: 112175685
2 APC NM_000038.5(APC): c.4391_4394delAGAG (p.Glu1464Valfs) deletion Pathogenic rs387906235 GRCh37 Chromosome 5, 112175682: 112175685

Expression for Periampullary Adenoma

Search GEO for disease gene expression data for Periampullary Adenoma.

Pathways for Periampullary Adenoma

Pathways related to Periampullary Adenoma according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1 12.35 APC HRAS KRAS
2 12.24 APC HRAS KRAS
3
Show member pathways
12.21 APC HRAS KRAS
4 12.14 APC HRAS KRAS
5
Show member pathways
12.06 APC HRAS KRAS
6 11.69 APC HRAS KRAS
7 11.52 APC HRAS KRAS
8 11.4 HRAS KRAS
9 11.39 APC HRAS KRAS
10 11.36 HRAS KRAS
11 11.29 HRAS KRAS
12
Show member pathways
11.24 GGT1 GGT2
13 11.21 HRAS KRAS
14 11.18 APC HRAS KRAS
15 11.1 HRAS KRAS
16 11.02 HRAS KRAS
17
Show member pathways
11 HRAS KRAS
18
Show member pathways
10.93 HRAS KRAS
19 10.87 GGT1 GGT2
20 10.84 GGT1 GGT2
21 10.82 HRAS KRAS
22 10.78 HRAS KRAS
23 10.71 HRAS KRAS
24 10.44 HRAS KRAS
25 10.28 APC HRAS KRAS

GO Terms for Periampullary Adenoma

Biological processes related to Periampullary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epidermal growth factor receptor signaling pathway GO:0007173 9.4 HRAS KRAS
2 ERBB2 signaling pathway GO:0038128 9.37 HRAS KRAS
3 regulation of long-term neuronal synaptic plasticity GO:0048169 9.32 HRAS KRAS
4 glutathione catabolic process GO:0006751 9.26 GGT1 GGT2
5 zymogen activation GO:0031638 9.16 GGT1 GGT2
6 leukotriene D4 biosynthetic process GO:1901750 8.96 GGT1 GGT2
7 response to isolation stress GO:0035900 8.62 HRAS KRAS

Molecular functions related to Periampullary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GDP binding GO:0019003 8.96 HRAS KRAS
2 glutathione hydrolase activity GO:0036374 8.62 GGT1 GGT2

Sources for Periampullary Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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