MCID: PRP002
MIFTS: 30

Periapical Granuloma malady

Category: Oral diseases

Aliases & Classifications for Periapical Granuloma

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Aliases & Descriptions for Periapical Granuloma:

Name: Periapical Granuloma 11 50 39 13 68
 
Apical Granuloma 11

Classifications:



External Ids:

Disease Ontology11 DOID:4617
SNOMED-CT62 196344002, 81407003
MeSH39 D010484

Summaries for Periapical Granuloma

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MalaCards based summary: Periapical Granuloma, also known as apical granuloma, is related to inflammatory liposarcoma and benign fibrous mesothelioma, and has symptoms including mass of digestive structure An important gene associated with Periapical Granuloma is TNFSF11 (Tumor Necrosis Factor Superfamily Member 11), and among its related pathways are NF-kappa B signaling pathway and EBV LMP1 signaling. Affiliated tissues include endothelial, neutrophil and t cells, and related mouse phenotype Decreased shRNA abundance (Z-score < -2).

Related Diseases for Periapical Granuloma

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Diseases related to Periapical Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
idRelated DiseaseScoreTop Affiliating Genes
1inflammatory liposarcoma10.2MMP8, TNFSF11
2benign fibrous mesothelioma10.2CXCL8, TNFSF11
3gonadal disease10.1CCL5, CXCL8
4orbital plasma cell granuloma10.1CCL5, CXCL8
5orbital lymphangioma10.1CCL5, CXCL8
6malakoplakia10.1CCL5, CXCL8
7dentin caries10.1CCL5, CXCL8
8iridocyclitis10.1CCL5, CXCL8
9pleomorphic lipoma10.1CXCL8, TNFSF11
10inner ear disease10.0CCL5, CXCL8
11osteogenesis imperfecta, type x10.0CXCL8, MMP8
12blind hypotensive eye10.0CCL5, CXCL8
13neonatal period electroclinical syndrome10.0CXCL8, MMP8
14diphtheria10.0CP, CXCL8
15geniculate herpes zoster10.0CCL5, CXCL8
16nervous system cancer10.0CXCL8, MMP8
17motion sickness9.9CCL5, CXCL8
18benign renovascular hypertension9.9CCL5, CXCL8
19asbestosis9.9CP, CXCL8
20neuroma9.9MMP13, TNFSF11
21laryngeal tuberculosis9.9CCL5, CXCL8
22actinic keratosis9.8MMP13, MMP8
23gemistocytic astrocytoma9.8CCL5, CXCL8, TNFSF11
24hyperpigmentation of eyelid9.8CCL5, CXCL8
25cervix carcinoma9.8CCL5, CXCL8
26lymphangioma9.8CXCL8, MMP8, TNFSF11
27eosinophilic gastroenteritis9.8CXCL8, MMP8, TNFSF11
28palmoplantar keratosis9.7CXCL8, MMP8, TNFSF11
29leprosy9.7
30lepromatous leprosy9.7
31endotheliitis9.7
32chronic rhinitis9.7CXCL8, MMP8, TNFSF11
33gingivitis9.7CCL5, CXCL8
34chronic endophthalmitis9.7CCL5, CP, CXCL8
35basaloid squamous cell carcinoma9.6CCL5, CXCL8
36malignant giant cell tumor9.5CXCL8, MMP13, TNFSF11
37xanthomatosis9.5CXCL8, MMP13, TNFSF11
38atherosclerosis9.5CXCL8, MMP13, TNFSF11
39rheumatoid arthritis9.1CCL5, CXCL8, MMP13, TNFSF11
40hydranencephaly9.0CCL5, CDH5, CP, CXCL8, TNFSF11

Graphical network of the top 20 diseases related to Periapical Granuloma:



Diseases related to periapical granuloma

Symptoms & Phenotypes for Periapical Granuloma

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UMLS symptoms related to Periapical Granuloma:


mass of digestive structure

GenomeRNAi Phenotypes related to Periapical Granuloma according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-586.6CDH5, MMP8, TNFSF11, CCL5, MMP13, TNFSF11

Drugs & Therapeutics for Periapical Granuloma

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Interventional clinical trials:

idNameStatusNCT IDPhase
1RCT: Effectiveness of a Microscope During Dental Root Apical SurgeryUnknown statusNCT01759069

Search NIH Clinical Center for Periapical Granuloma


Cochrane evidence based reviews: periapical granuloma

Genetic Tests for Periapical Granuloma

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Anatomical Context for Periapical Granuloma

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MalaCards organs/tissues related to Periapical Granuloma:

36
Endothelial, Neutrophil, T cells, Monocytes, Colon, Bone

Publications for Periapical Granuloma

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Articles related to Periapical Granuloma:

(show all 35)
idTitleAuthorsYear
1
Bioinformatics, Interaction Network Analysis, and Neural Networks to Characterize Gene Expression of Radicular Cyst and Periapical Granuloma. (25873079)
2015
2
Expression and immunohistochemical localization of leptin receptor in human periapical granuloma. (25081278)
2014
3
Heparanase expression in periapical granulomas and radicular cysts. (22020734)
2013
4
Oral pathology quiz #81. Case number 4. Dental (periapical) granuloma. (24597181)
2013
5
Periapical granuloma associated with extracted teeth. (22037071)
2011
6
Midkine expression in human periapical granulomas. (21787488)
2011
7
T-helper cell type 17/regulatory T-cell immunoregulatory balance in human radicular cysts and periapical granulomas. (20478453)
2010
8
Distinct Th1, Th2 and Treg cytokines balance in chronic periapical granulomas and radicular cysts. (20102461)
2010
9
High matrix metalloproteinase activity is a hallmark of periapical granulomas. (19720222)
2009
10
Antrochoanal polyp derived from periapical granuloma. (18701055)
2008
11
Differential patterns of receptor activator of nuclear factor kappa B ligand/osteoprotegerin expression in human periapical granulomas: possible association with progressive or stable nature of the lesions. (18634923)
2008
12
Involvement of inducible nitric oxide synthase and receptor for advanced glycation end products in periapical granulomas. (17258631)
2007
13
RANKL in human periapical granuloma: possible involvement in periapical bone destruction. (16700737)
2006
14
Co-production of vascular endothelial cadherin and inducible nitric oxide synthase by endothelial cells in periapical granuloma. (16507070)
2006
15
Oral diagnosis. Interradicular radiolucency of maxilla. Periapical granuloma. (16161239)
2005
16
Intraneural epithelial islands associated with a periapical granuloma: a cause for concern? (12796887)
2003
17
Hydrogen peroxide and superoxide anion production by polymorphonuclear neutrophils in patients with chronic periapical granuloma, before and after surgical treatment. (11355101)
2001
18
Evaluation of immunoglobulin G synthesizing plasma cells in periapical granuloma and cyst. (11441800)
2001
19
The presence of chemokine receptor (CCR5, CXCR3, CCR3)-positive cells and chemokine (MCP1, MIP-1alpha, MIP-1beta, IP-10)-positive cells in human periapical granulomas. (11683586)
2001
20
Differential in situ distribution of interleukin-8, monocyte chemoattractant protein-1 and Rantes in human chronic periapical granuloma. (11155167)
2000
21
Cytotoxic T lymphocytes versus streptococcal colonization in periapical granulomas. (10425947)
1999
22
Focal cemento-osseous dysplasia in the maxilla mimicking periapical granuloma. (10442950)
1999
23
Interferon-gamma-producing cells and inducible nitric oxide synthase-producing cells in periapical granulomas. (9563799)
1998
24
Immune cells in periapical granuloma: morphological and immunohistochemical characterization. (1895036)
1991
25
Quantitative analysis of the immunocompetent cells in periapical granuloma: correlation with the histological characteristics of the lesions. (1974913)
1990
26
The role of acute phase proteins in the pathogenesis of chronic periapical granuloma]. (1698164)
1990
27
Acute phase proteins in patients with chronic periapical granuloma before and after surgical treatment. (3268759)
1988
28
Endodontic treatment and immunopathology of periapical granuloma in an AIDS patient. (2977755)
1988
29
In situ characterization of cells in periapical granuloma by monoclonal antibodies. (3477750)
1987
30
Bacteriological status of periapical granuloma. (6597195)
1984
31
Macrophages isolated from periapical granuloma: a scanning electron microscopic study. (6592531)
1984
32
Isolation and characterization of inflammatory cells from the human periapical granuloma. (6983538)
1982
33
Quantitative analysis of cellular composition of human periapical granuloma. (6938631)
1981
34
Reddening of the upper central incisors associated with periapical granuloma in lepromatous leprosy. (1063039)
1976
35
A colony of actinomyces-like organisms in a periapical granuloma. (4161341)
1966

Variations for Periapical Granuloma

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Expression for genes affiliated with Periapical Granuloma

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Search GEO for disease gene expression data for Periapical Granuloma.

Pathways for genes affiliated with Periapical Granuloma

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GO Terms for genes affiliated with Periapical Granuloma

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Cellular components related to Periapical Granuloma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.9CCL5, CP, CXCL8, MMP13, MMP8, TNFSF11
2extracellular spaceGO:00056157.2CCL5, CP, CXCL8, MMP13, MMP8, TNFSF11

Biological processes related to Periapical Granuloma according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1monocyte chemotaxisGO:000254810.3CCL5, TNFSF11
2positive regulation of homotypic cell-cell adhesionGO:003411210.2CCL5, TNFSF11
3positive regulation of osteoclast differentiationGO:004567210.2CCL5, TNFSF11
4cellular response to fibroblast growth factor stimulusGO:004434410.2CCL5, CXCL8
5cellular response to interleukin-1GO:007134710.2CCL5, CXCL8
6positive regulation of phosphorylationGO:004232710.2CCL5, TNFSF11
7chemokine-mediated signaling pathwayGO:007009810.2CCL5, CXCL8
8negative regulation of G-protein coupled receptor protein signaling pathwayGO:004574410.1CCL5, CXCL8
9neutrophil activationGO:004211910.1CCL5, CXCL8
10neutrophil chemotaxisGO:003059310.1CCL5, CXCL8
11collagen catabolic processGO:00305749.7MMP13, MMP8
12extracellular matrix disassemblyGO:00226179.6MMP13, MMP8
13response to estrogenGO:00436279.4CCL5, MMP13

Molecular functions related to Periapical Granuloma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00080099.5CCL5, CXCL8

Sources for Periapical Granuloma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet