MCID: PRP002
MIFTS: 51

Periapical Granuloma malady

Oral diseases category
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Summaries for Periapical Granuloma

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33MalaCards
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MalaCards: Periapical Granuloma, also known as apical granuloma, is related to leprosy and lepromatous leprosy. An important gene associated with Periapical Granuloma is MMP8 (matrix metallopeptidase 8 (neutrophil collagenase)), and among its related pathways are Matrix Metalloproteinases and IL2 signaling events mediated by PI3K. The compounds mcp 1 and gold sodium thiomalate have been mentioned in the context of this disorder. Affiliated tissues include endothelial, bone and colon, and related mouse phenotypes are no phenotypic analysis and vision/eye.

Aliases & Classifications for Periapical Granuloma

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8Disease Ontology, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Oral diseases


Aliases & Descriptions:

periapical granuloma 8 45 62
apical granuloma 8


External Ids:

Disease Ontology8 DOID:4617
SNOMED-CT58 196344002, 81407003
MeSH35 D010484

Related Diseases for Periapical Granuloma

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17GeneCards, 18GeneDecks
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Diseases related to Periapical Granuloma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1leprosy30.4IL2
2lepromatous leprosy30.2IL2, IL4, IFNG
3endotheliitis10.2
4farmer's lung10.1IL2RA
5bronchiolitis10.1CCL5, CCL3
6meningococcemia10.1CCL5
7proliferative glomerulonephritis10.1CCL2, CXCR3
8bacterial meningitis10.1CCL4, CCL3, MMP8
9intermediate uveitis10.1IL2RA, CCR5, CXCR3
10dengue disease10.1CCL4, CCL5, CCL3
11bronchiolitis obliterans10.1CXCR3, MMP8
12periodontal disease10.1TNFSF11, TNF
13pulpitis10.1IL1A
14mast-cell leukemia10.1CCL2, CCL5, CCL3
15vernal keratoconjunctivitis10.1IL4, CCL5, CXCR3
16polyostotic osteolytic dysplasia, hereditary expansile10.1TNFRSF11B, TNFSF11
17paget disease, juvenile10.1TNFRSF11B, TNFSF11
18central nervous system disease10.1CCR5, CCL2, CXCR3
19peripheral t-cell lymphoma10.1NOS2, IL2RA, CXCR3
20sjogren's syndrome10.1IL2RA, CCL3, CXCR3
21aggressive periodontitis10.1IL1A, MMP8
22pulmonary eosinophilia10.1IL4, CCL3
23contact dermatitis10.1IL1A, CXCR3
24pleurisy10.1IL2RA
25gastritis10.1NOS2, CCL5, CCL3
26osteosclerosis10.1TNFRSF11B, TNFSF11
27factor v leiden thrombophilia10.1CCL5, MMP8, MMP13, TNFSF11
28bone carcinoma10.1MMP13, TNFRSF11B, TNFSF11
29aortic valve stenosis10.1CCR5, TNFRSF11B, TNFSF11
30extrinsic allergic alveolitis10.1IL1A, CCL3
31cerebrovascular disease10.1CCL4, CCL3, MMP8, MMP13
32acute myocardial infarction10.1CDH5, CCL5, MMP8, TNFSF11
33idiopathic myopathy10.1IL1A, CCL2, CCL5
34peritonitis10.0CCL2, MMP8, TNF
35middle ear cholesteatoma10.0IL1A, TNFSF11
36glomerulonephritis10.0NOS2, CCL4, CCR5, CCL2
37aspergillosis10.0IFNG, CCL3
38aids dementia complex10.0NOS2, CCR5, TNF
39multiple myeloma10.0CCL3, TNFRSF11B, TNFSF11
40pulmonary fibrosis10.0CCL4, CCL2, CCL3, CXCR3, MMP13
41polymyositis10.0IL1A, CCR5, CCL3
42agammaglobulinemia10.0IL2, IL4
43osteoporosis10.0MMP8, MMP13, TNFRSF11B, TNFSF11
44periodontitis10.0IL1A, MMP8, TNFRSF11B
45secondary syphilis10.0CCL4, CCL3, TNFRSF11B, TNFSF11
46burkitt's lymphoma10.0IL4, CCL3, CXCR3
47oral lichen planus10.0IL1A, CCR5, CCL5, CXCR3
48mycosis fungoides10.0IL2RA, IL2, CXCR3
49tuberculoid leprosy10.0IL2RA, IFNG
50lupus nephritis10.0IL2RA, CCR5, CCL2, CCL5, CXCR3

Graphical network of the top 20 diseases related to Periapical Granuloma:



Diseases related to periapical granuloma

Symptoms for Periapical Granuloma

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Drugs & Therapeutics for Periapical Granuloma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Periapical Granuloma

Search NIH Clinical Center for Periapical Granuloma

Genetic Tests for Periapical Granuloma

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Anatomical Context for Periapical Granuloma

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33MalaCards
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MalaCards organs/tissues related to Periapical Granuloma:

33
Endothelial, Bone, Colon, T cells

Animal Models for Periapical Granuloma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Periapical Granuloma:

37 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.4TNF, TNFSF11, CCR5, IFNG, IL4, IL2
2MP:00053918.3TNF, CCL2, CCR5, IFNG, IL4, NOS2
3MP:00053908.1TNF, TNFSF11, TNFRSF11B, MMP13, CCL2, IFNG
4MP:00053828.1TNF, TNFSF11, TNFRSF11B, CCL2, IFNG, IL4
5MP:00053798.1TNF, TNFSF11, IFNG, IL4, IL2, HPSE
6MP:00053888.0TNF, CXCR3, IFNG, IL4, IL2, NOS2
7MP:00020067.9TNF, MMP8, CXCR3, CCL2, CCR5, IFNG
8MP:00107717.9TNF, TNFSF11, MMP13, CCL2, IFNG, IL4
9MP:00053707.8TNF, CCL2, CCR5, IFNG, IL4, IL2
10MP:00053897.5TNF, TNFSF11, CCL2, CCR5, IFNG, IL4
11MP:00053817.3TNF, CCL3, CCL2, CCR5, IFNG, IL4
12MP:00036317.1CCL3, CCL2, CCR5, IFNG, IL4, NOS2
13MP:00053866.9TNF, CCL3, CCL2, CCR5, IFNG, IL2
14MP:00053786.4CCL3, MMP13, TNFRSF11B, TNFSF11, TNF, CCL2
15MP:00053856.4TNF, TNFRSF11B, MMP13, CXCR3, CCL2, CCR5
16MP:00107686.2CCL3, CXCR3, TNFRSF11B, TNFSF11, TNF, CCL2
17MP:00053766.0CCL3, CXCR3, MMP13, TNFSF11, TNF, CCL2
18MP:00053846.0CCL3, CXCR3, MMP13, TNFRSF11B, TNF, CCL2
19MP:00053875.0TNF, CDH5, MDK, NOS2, IL1A, IL2RA
20MP:00053974.8TNF, MDK, NOS2, HPSE, IL1A, IL2RA

Publications for Periapical Granuloma

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52PubMed
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Articles related to Periapical Granuloma:

(show all 31)
idTitleAuthorsYear
1
Heparanase expression in periapical granulomas and radicular cysts. (22020734)
2013
2
Periapical granuloma associated with extracted teeth. (22037071)
2011
3
Midkine expression in human periapical granulomas. (21787488)
2011
4
Distinct Th1, Th2 and Treg cytokines balance in chronic periapical granulomas and radicular cysts. (20102461)
2010
5
T-helper cell type 17/regulatory T-cell immunoregulatory balance in human radicular cysts and periapical granulomas. (20478453)
2010
6
High matrix metalloproteinase activity is a hallmark of periapical granulomas. (19720222)
2009
7
Antrochoanal polyp derived from periapical granuloma. (18701055)
2008
8
Differential patterns of receptor activator of nuclear factor kappa B ligand/osteoprotegerin expression in human periapical granulomas: possible association with progressive or stable nature of the lesions. (18634923)
2008
9
Involvement of inducible nitric oxide synthase and receptor for advanced glycation end products in periapical granulomas. (17258631)
2007
10
RANKL in human periapical granuloma: possible involvement in periapical bone destruction. (16700737)
2006
11
Co-production of vascular endothelial cadherin and inducible nitric oxide synthase by endothelial cells in periapical granuloma. (16507070)
2006
12
Oral diagnosis. Interradicular radiolucency of maxilla. Periapical granuloma. (16161239)
2005
13
Intraneural epithelial islands associated with a periapical granuloma: a cause for concern? (12796887)
2003
14
Hydrogen peroxide and superoxide anion production by polymorphonuclear neutrophils in patients with chronic periapical granuloma, before and after surgical treatment. (11355101)
2001
15
Evaluation of immunoglobulin G synthesizing plasma cells in periapical granuloma and cyst. (11441800)
2001
16
The presence of chemokine receptor (CCR5, CXCR3, CCR3)-positive cells and chemokine (MCP1, MIP-1alpha, MIP-1beta, IP-10)-positive cells in human periapical granulomas. (11683586)
2001
17
Cytotoxic T lymphocytes versus streptococcal colonization in periapical granulomas. (10425947)
1999
18
Focal cemento-osseous dysplasia in the maxilla mimicking periapical granuloma. (10442950)
1999
19
Interferon-gamma-producing cells and inducible nitric oxide synthase-producing cells in periapical granulomas. (9563799)
1998
20
Immune cells in periapical granuloma: morphological and immunohistochemical characterization. (1895036)
1991
21
Quantitative analysis of the immunocompetent cells in periapical granuloma: correlation with the histological characteristics of the lesions. (1974913)
1990
22
The role of acute phase proteins in the pathogenesis of chronic periapical granuloma]. (1698164)
1990
23
Acute phase proteins in patients with chronic periapical granuloma before and after surgical treatment. (3268759)
1988
24
Endodontic treatment and immunopathology of periapical granuloma in an AIDS patient. (2977755)
1988
25
In situ characterization of cells in periapical granuloma by monoclonal antibodies. (3477750)
1987
26
Bacteriological status of periapical granuloma. (6597195)
1984
27
Macrophages isolated from periapical granuloma: a scanning electron microscopic study. (6592531)
1984
28
Isolation and characterization of inflammatory cells from the human periapical granuloma. (6983538)
1982
29
Quantitative analysis of cellular composition of human periapical granuloma. (6938631)
1981
30
Reddening of the upper central incisors associated with periapical granuloma in lepromatous leprosy. (1063039)
1976
31
A colony of actinomyces-like organisms in a periapical granuloma. (4161341)
1966

Variations for Periapical Granuloma

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Expression for genes affiliated with Periapical Granuloma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Periapical Granuloma

Search GEO for disease gene expression data for Periapical Granuloma.

Pathways for genes affiliated with Periapical Granuloma

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50PathCards, 38NCBI BioSystems Database, 53QIAGEN, 55Reactome, 30KEGG, 5Cell Signaling Technology, 54R&D Systems, 60Thomson Reuters
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Pathways related to Periapical Granuloma according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6MMP8, MMP13, TNF
2
Show member pathways
IL2 signaling events mediated by STAT538
9.5IL2RA, IL2, IL4
3
Show member pathways
9.4TNFRSF11B, TNFSF11, TNF
49.4IL2RA, IL2, IFNG
59.3IFNG, IL4, IL2
69.2IFNG, CCL2, TNF
79.2TNF, CCL2, IFNG
89.1TNFSF11, CCL5, IL4, IL2, IL2RA
9
Show member pathways
IL27-mediated signaling events38
9.1IL2, IFNG, TNF
109.1IFNG, IL4, IL2, IL2RA
11
Show member pathways
Type III interferon signaling38
9.1IFNG, IL4, IL2, IL2RA
129.1TNF, IL4, IL2RA, IL1A
13
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.0TNF, IL4, IL2, IL2RA
14
Show member pathways
8.9IL1A, IFNG, CCR5, TNF
158.9CCL2, CCL3, TNF
168.9NOS2, IL1A, IFNG, TNF
17
Show member pathways
Immune response MIF in innate immunity response60
8.9TNF, IFNG, IL1A, NOS2
18
Show member pathways
Ras signaling in the CD4+ TCR pathway38
8.8IL2RA, IL2, IFNG, TNF
198.8NOS2, IL2, IFNG, TNF
20
Show member pathways
Immune response CD16 signaling in NK cells60
8.8TNF, IFNG, IL4, IL2
21
Show member pathways
8.8CCL2, IL4, IL2, IL2RA, MDK
22
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
8.7TNF, TNFSF11, TNFRSF11B, CCL5, CCL2, CCR5
23
Show member pathways
8.6CCL4, CCR5, CCL5, CCL3
24
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.6TNF, IFNG, IL4, IL1A, NOS2
25
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.6TNF, CCL2, IFNG, IL2, NOS2
26
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
8.6TNF, IFNG, IL4, IL2, IL2RA
278.6TNF, TNFSF11, TNFRSF11B, IFNG, IL1A
288.6TNF, TNFSF11, TNFRSF11B, IFNG, IL1A
298.4TNF, IFNG, IL4, IL2, IL1A
308.4TNF, IFNG, IL4, IL2, IL1A
31
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
8.2TNF, CCR5, IFNG, IL4, IL2, IL1A
32
Show member pathways
8.2TNF, IFNG, IL4, IL2, IL2RA, IL1A
33
Show member pathways
8.2TNF, IFNG, IL4, IL2, IL2RA, IL1A
34
Show member pathways
8.1CXCR3, CCL3, CCL5, CCL2, CCR5, CCL4
35
Show member pathways
8.1CXCR3, CCL3, CCL5, CCL2, CCR5, CCL4
36
Show member pathways
8.1CXCR3, CCL3, CCL5, CCL2, CCR5, CCL4
37
Show member pathways
7.9CCL3, CCL4, IFNG, IL1A, NOS2
38
Show member pathways
7.9TNF, CCR5, IFNG, IL4, IL2, IL1A
397.9TNF, CCL2, IFNG, IL4, IL2, IL1A
40
Show member pathways
7.7TNF, CCL5, CCL2, IFNG, IL4, IL2
417.6TNF, TNFSF11, CCL3, CCL5, CCL2, IFNG
42
Show member pathways
7.5MMP13, MMP8, CXCR3, CCL3, CCL5, CCL2
43
Show member pathways
7.4TNF, CCL3, CCL4, IFNG, IL2, IL2RA
44
Show member pathways
Immune response IL 12 induced IFN gamma production60
7.1CCL3, CCR5, CCL4, IFNG, IL4, IL2
45
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
6.9TNF, CCL3, CCL5, CCL2, CCL4, IFNG
46
Show member pathways
5.8TNF, CCL3, CCL5, CCL2, CCL4, IFNG
47
Show member pathways
5.6IL2, IL2RA, IL1A, MDK, IL4, CCL4
48
Show member pathways
5.6TNF, TNFSF11, CXCR3, CCL3, CCL5, CCL2
49
Show member pathways
5.3IL1A, IL2RA, TNF, TNFSF11, TNFRSF11B, CXCR3
50
Show member pathways
5.3TNF, TNFSF11, CXCR3, CCL3, CCL5, CCL2

Compounds for genes affiliated with Periapical Granuloma

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 24HMDB, 3BitterDB
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Compounds related to Periapical Granuloma according to GeneCards/GeneDecks:

(show top 50)    (show all 246)
idCompoundScoreTop Affiliating Genes
1mcp 1458.6CCL3, CCL5, CCL2, CCL4, CXCR3
2gold sodium thiomalate458.5IFNG, IL1A, IL2RA, IL2, TNF
3infliximab45 51 1110.5TNFRSF11B, TNFSF11, CXCR3, TNF, IFNG, IL4
4polymyxin b458.4IL1A, IL4, IFNG, CCL2, TNFRSF11B, TNFSF11
5mdms458.2CCL3, CCL4, CCL2, CCL5, CCR5
6pentoxifylline45 119.2IL2, IL1A, IL4, IFNG, TNF, IL2RA
7larc458.2IL1A, CCL4, CCR5, CCL2, CCL5, CCL3
8thalidomide45 51 61 1111.2IL1A, IL2RA, IL2, IFNG, CCL5, TNFRSF11B
9ccl445 299.1CCL4, CCR5, CCL2, CCL5, CCL3, CXCR3
10ivig458.0TNF, CCR5, CCL4, IFNG, IL4, IL2RA
11toxin-1458.0IL2, CCL3, CCL4, TNF, CCL2
12ribavirin45 51 119.8IL4, IL2, IFNG, CCR5, CCL3, CXCR3
13calcitriol45 61 24 1110.7TNF, IL2RA, IL1A, IFNG, IL4, TNFSF11
14mip 1alpha457.7IL4, CCL4, CCR5, CCL2, CCL5, CCL3
15polyinosinic-polycytidylic acid457.7IL4, IL1A, IL2, IFNG, CCL3, NOS2
16pdtc457.7IL4, IFNG, CCL2, CCL5, CCL3, TNF
17neopterin457.6IL1A, IL2RA, IL2, IL4, CCL3, TNF
18ly294002457.6CCL5, TNF, TNFSF11, NOS2, IL4, CCL2
19herbimycin a45 618.6MMP13, TNF, CCL2, IFNG, NOS2, HPSE
20gm-csf45 298.6IL1A, IL2, IL4, IFNG, CCL2, CCL5
21heparan sulfate45 248.5CCL5, CCL4, MDK, CCL3, TNFRSF11B, TNFSF11
22groalpha457.5CCL5, CCL3, CXCR3, MMP13, TNF, CCL2
23triptolide457.3NOS2, IL2, IFNG, CCL4, CCL5, CCL3
24ccl345 298.2CCL3, CXCR3, TNF, IL1A, IFNG, CCL4
25endotoxin457.2NOS2, IL1A, IFNG, CCL4, CCL2, CCL5
26prednisolone45 29 119.2TNF, TNFRSF11B, CCL3, CCL4, IFNG, IL2
27simvastatin45 51 61 29 24 1112.1IL1A, IL4, IFNG, CCL4, CCR5, CCL2
28hydrocortisone45 3 61 1110.0CDH5, IL1A, IL2, IL4, IFNG, CCL5
29actinomycin d457.0CCL2, TNF, NOS2, MMP13, CCL3, CCR5
30ionomycin457.0IL1A, IL2RA, IL2, IL4, IFNG, CCL4
31thymidine45 248.0CXCR3, TNF, MMP13, CCL3, IFNG, IL2RA
32tacrolimus45 51 118.9IL2RA, IL2, IL4, IFNG, CCL4, CCL5
33tarc456.9CCR5, CCL2, CCL5, CCL3, CXCR3, TNF
34genistein45 29 61 3 24 1111.9MMP8, CCL5, CCL2, IFNG, IL2, IL2RA
35oxygen45 247.8CXCR3, CCL3, CCL4, HPSE, NOS2, CDH5
36cysteine456.8TNFSF11, CCL3, CCL5, TNFRSF11B, MMP13, CCL4
37heparin45 29 24 119.5TNFSF11, TNFRSF11B, MMP13, CXCR3, CCL3, CCL5
38histamine45 29 248.4IL4, IFNG, CCL4, CCR5, CCL2, CCL5
39sb 20358045 617.3CCL5, CCL3, MMP13, TNFRSF11B, TNFSF11, TNF
40il 10456.3CCL4, CCR5, CCL2, CCL5, CCL3, CXCR3
41retinoic acid45 247.1CCR5, CCL3, MMP8, MMP13, TNF, CCL5
42cyclosporin a45 29 618.0IL1A, TNF, IL2RA, IL2, IL4, IFNG
43indomethacin45 29 61 118.9CCL5, CCL3, MMP13, TNFRSF11B, TNFSF11, TNF
44serine455.9CCL3, IL2, CCL4, MMP8, HPSE, TNFSF11
45cycloheximide455.8TNFRSF11B, CCL4, IFNG, IL4, IL1A, IL2
46nitric oxide45 24 117.6TNF, TNFSF11, TNFRSF11B, MMP13, MMP8, CXCR3
47rantes455.5TNFSF11, TNF, IL2RA, IL2, IL4, IFNG
48dexamethasone45 51 29 118.2TNF, TNFSF11, TNFRSF11B, MMP13, CXCR3, CCL3
49pge2455.0NOS2, CCR5, CCL2, CCL5, CCL4, IFNG
50vegf454.6IL2RA, IL1A, HPSE, NOS2, CDH5, IL2

GO Terms for genes affiliated with Periapical Granuloma

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16Gene Ontology
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Cellular components related to Periapical Granuloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.5CXCR3, CCR5, IFNG, IL4, IL2RA, TNF
2extracellular spaceGO:0056155.3IL2, IL4, IFNG, CCL4, CCL2, CCL5
3extracellular regionGO:0055764.9MDK, TNF, HPSE, IL1A, IL2, IFNG

Biological processes related to Periapical Granuloma according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of homotypic cell-cell adhesionGO:03411210.3TNFSF11, CCL5
2regulation of T cell homeostatic proliferationGO:04601310.2IL2, IL2RA
3chemokine-mediated signaling pathwayGO:07009810.1CCL5, CCL2, CCR5
4positive regulation of killing of cells of other organismGO:05171210.1IFNG, NOS2
5innate immune response in mucosaGO:00222710.0IL4, NOS2
6positive regulation of activated T cell proliferationGO:0421049.9IL4, IL2, IL2RA
7positive regulation of hair follicle developmentGO:0517989.9TNF, HPSE
8positive regulation of vitamin D biosynthetic processGO:0605579.9TNF, IFNG
9positive regulation of calcidiol 1-monooxygenase activityGO:0605599.8TNF, IFNG
10positive regulation of T cell proliferationGO:0421029.8CCL5, IFNG, IL4
11signalingGO:0230529.8CCL3, CCR5
12positive regulation of isotype switching to IgG isotypesGO:0483049.8IFNG, IL4, IL2
13extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.7IL4, IL2, IL1A
14cellular response to lipopolysaccharideGO:0712229.7CCL2, CCR5, IFNG, NOS2
15positive regulation of osteoclast differentiationGO:0456729.7IFNG, TNFSF11, TNF
16positive regulation of MHC class II biosynthetic processGO:0453489.6IL4, IFNG
17positive regulation of chemokine biosynthetic processGO:0450809.6TNF, IFNG, IL4
18T cell chemotaxisGO:0108189.6CXCR3, CCL3
19astrocyte cell migrationGO:0436159.6CCL3, CCL2
20release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:0148089.6CCL3, CCR5
21macrophage chemotaxisGO:0482469.6CCL2, CCL5, CCL3
22cellular response to interleukin-1GO:0713479.5CCL2, CCL5, CCL3
23humoral immune responseGO:0069599.5IFNG, CCL2, TNF
24cell surface receptor signaling pathwayGO:0071669.5IL2RA, IFNG, CCR5, CCL2, CXCR3
25cellular response to tumor necrosis factorGO:0713569.4CCL2, CCL5, CCL3
26response to cholesterolGO:0707239.4CCR5, CCL3
27monocyte chemotaxisGO:0025489.4CCL2, CCL5, CCL3, TNFSF11
28cytokine-mediated signaling pathwayGO:0192219.4TNFSF11, CCL2, IFNG, IL1A
29cellular response to interferon-gammaGO:0713469.4NOS2, CCL2, CCL5, CCL3
30neutrophil chemotaxisGO:0305939.3IFNG, CCL2, CCL3
31positive regulation of natural killer cell chemotaxisGO:20005039.3CCL4, CCL5, CCL3
32negative regulation by host of viral transcriptionGO:0439229.2CCL3, CCL5, CCL4
33positive regulation of calcium ion transportGO:0519289.2CCL4, CCL5, CCL3
34cell activationGO:0017759.1CCL3, TNF
35calcium-mediated signalingGO:0197229.1CCR5, CCL3, CXCR3, TNF
36lipopolysaccharide-mediated signaling pathwayGO:0316639.1TNF, CCL3, CCL5, CCL2
37protein kinase B signalingGO:0434919.1TNF, CCL3, CCL5, CCL2
38lymphocyte chemotaxisGO:0482479.1CCL2, CCL3
39cellular response to organic cyclic compoundGO:0714079.1TNF, CCL3, CCL5, CCL2
40response to virusGO:0096159.0TNF, CCL5, CCL4, IFNG
41positive regulation of protein kinase B signalingGO:0518979.0TNF, TNFSF11, CCL3, HPSE
42chemotaxisGO:0069358.9CXCR3, CCL3, CCL5, CCL2, CCR5, IL4
43response to toxic substanceGO:0096368.9CCL3, CCL5, CCL4
44MAPK cascadeGO:0001658.9TNF, CCL3, CCL5, CCL2, CCR5
45apoptotic processGO:0069158.7TNF, TNFRSF11B, CXCR3, IFNG, IL2RA, IL1A
46cell-cell signalingGO:0072678.6CCL3, CCL5, CCR5, CCL4, IL2
47immune responseGO:0069558.5TNFSF11, CCR5, CCL4, IL4, IL2, IL2RA
48response to drugGO:0424938.5TNF, TNFRSF11B, CCL2, IFNG, IL4, MDK
49positive regulation of transcription from RNA polymerase II promoterGO:0459448.4TNF, TNFSF11, CXCR3, IFNG, IL4, IL2
50inflammatory responseGO:0069547.4NOS2, TNF, CXCR3, CCL3, CCL5, CCL2

Molecular functions related to Periapical Granuloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00495010.1CCR5, CXCR3
2phospholipase activator activityGO:0160049.1CCL5, CCL3
3CCR5 chemokine receptor bindingGO:0317308.9CCL3, CCL5, CCL4
4CCR1 chemokine receptor bindingGO:0317268.8CCL3, CCL5, CCL4
5chemokine activityGO:0080098.5CCL3, CCL5, CCL2, CCL4
6cytokine activityGO:0051257.4IL1A, TNF, TNFSF11, TNFRSF11B, CCL4, IFNG

Products for genes affiliated with Periapical Granuloma

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Sources for Periapical Granuloma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet