Aliases & Classifications for Periapical Granuloma

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Aliases & Descriptions for Periapical Granuloma:

Name: Periapical Granuloma 10 47 12 36 65
 
Apical Granuloma 10

Classifications:



External Ids:

Disease Ontology10 DOID:4617
SNOMED-CT59 196344002, 81407003
MeSH36 D010484
UMLS65 C0031029

Summaries for Periapical Granuloma

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MalaCards based summary: Periapical Granuloma, also known as apical granuloma, is related to intrahepatic biliary papillomatosis and basilar artery occlusion, and has symptoms including mass of digestive structure An important gene associated with Periapical Granuloma is TNFSF11 (Tumor Necrosis Factor Superfamily Member 11), and among its related pathways are Development_Hedgehog and PTH signaling pathways in bone and cartilage development and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. Affiliated tissues include kidney, t cells and neutrophil, and related mouse phenotypes are homeostasis/metabolism and immune system.

Related Diseases for Periapical Granuloma

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Diseases related to Periapical Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1intrahepatic biliary papillomatosis10.3MMP8, TNFSF11
2basilar artery occlusion10.3CCL5, IL2
3otosalpingitis10.3MMP13, TNFSF11
4colon sarcoma10.2CCL5, IL2
5eosinophilic gastritis10.2MMP8, TNFSF11
6pulmonary subvalvular stenosis10.1MMP13, MMP8
7goat milk allergy10.1IL4, TNFSF11
8acute orbital inflammation10.0IL4, TNFSF11
9limbic encephalitis with ncmags antibodies10.0IL2, IL4
10baylisascariasis10.0IL2, IL4
11epididymis cancer10.0IL2, IL4
12cd45 deficiency10.0IL2, IL4
13collagenous colitis10.0IL2, IL4
14b cell deficiency10.0IL2, IL4
15vulvovaginitis10.0IL2, IL4
16chronic conjunctivitis10.0IL2, IL4
17acute leukemia of ambiguous lineage10.0IL2, IL4
18polycystic kidney disease10.0IL2, IL4
19tethered spinal cord syndrome10.0IL2, IL4
20leech infestation10.0IL2, IL4
21chronic eosinophilic pneumonia9.9IL2, IL4
22motor peripheral neuropathy9.9CCL5, IL4
23leukoplakia of penis9.9IL2, IL4
24familial hyperlipidemia9.9CCL5, IL4
25necatoriasis9.9IL2, IL4
26degenerative disc disease9.9IL2, IL4
27commensal bacterial infectious disease9.9IL2, IL4
28ovarian endometrioid cystadenoma9.9IL2, IL4
29giant papillary conjunctivitis9.9IL4, MMP8
30leprosy9.9
31lepromatous leprosy9.9
32endotheliitis9.9
33hodgkin's lymphoma, lymphocytic-histiocytic predominance9.9IL2, IL4
34hard palate cancer9.8IL2, IL4
35multiple symmetric lipomatosis9.8IL2, IL4
36meningeal melanomatosis9.8MMP13, MMP8, TNFSF11
37bladder urachal adenocarcinoma9.8MMP13, MMP8
38periodic limb movement disorder9.8IL2, IL4
39kohler's disease9.8CCL5, IL4
40methylmalonic acidemia9.8IL4, MMP8
41uterine corpus epithelioid leiomyoma9.7IL2, IL4
42diffuse scleroderma9.7CCL5, IL4
43spleen angiosarcoma9.7IL2, IL4, TNFSF11
44severe acute respiratory syndrome9.6CCL5, IL4
45pneumocystosis9.6IL2, IL4
46blepharitis9.5CCL5, IL4
47orbital plasma cell granuloma9.5CCL5, IL2, IL4
48eyelid degenerative disease9.5CCL5, IL2, IL4
49hypoglycemia9.5CCL5, IL2, IL4
50urethral diverticulum9.5CCL5, IL2, IL4

Graphical network of the top 20 diseases related to Periapical Granuloma:



Diseases related to periapical granuloma

Symptoms for Periapical Granuloma

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UMLS symptoms related to Periapical Granuloma:


mass of digestive structure

Drugs & Therapeutics for Periapical Granuloma

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Interventional clinical trials:

idNameStatusNCT IDPhase
1RCT: Effectiveness of a Microscope During Dental Root Apical SurgeryRecruitingNCT01759069

Search NIH Clinical Center for Periapical Granuloma


Cochrane evidence based reviews: periapical granuloma

Genetic Tests for Periapical Granuloma

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Anatomical Context for Periapical Granuloma

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MalaCards organs/tissues related to Periapical Granuloma:

33
Kidney, T cells, Neutrophil, Colon, Breast, Myeloid, B cells

Animal Models for Periapical Granuloma or affiliated genes

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MGI Mouse Phenotypes related to Periapical Granuloma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.9CDH5, IL2, IL4, MMP13, MMP8, TNFSF11
2MP:00053877.3CCL5, CDH5, IL2, IL4, MMP8, TNFSF11

Publications for Periapical Granuloma

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Articles related to Periapical Granuloma:

(show all 35)
idTitleAuthorsYear
1
Bioinformatics, Interaction Network Analysis, and Neural Networks to Characterize Gene Expression of Radicular Cyst and Periapical Granuloma. (25873079)
2015
2
Expression and immunohistochemical localization of leptin receptor in human periapical granuloma. (25081278)
2014
3
Heparanase expression in periapical granulomas and radicular cysts. (22020734)
2013
4
Oral pathology quiz #81. Case number 4. Dental (periapical) granuloma. (24597181)
2013
5
Periapical granuloma associated with extracted teeth. (22037071)
2011
6
Midkine expression in human periapical granulomas. (21787488)
2011
7
Distinct Th1, Th2 and Treg cytokines balance in chronic periapical granulomas and radicular cysts. (20102461)
2010
8
T-helper cell type 17/regulatory T-cell immunoregulatory balance in human radicular cysts and periapical granulomas. (20478453)
2010
9
High matrix metalloproteinase activity is a hallmark of periapical granulomas. (19720222)
2009
10
Antrochoanal polyp derived from periapical granuloma. (18701055)
2008
11
Differential patterns of receptor activator of nuclear factor kappa B ligand/osteoprotegerin expression in human periapical granulomas: possible association with progressive or stable nature of the lesions. (18634923)
2008
12
Involvement of inducible nitric oxide synthase and receptor for advanced glycation end products in periapical granulomas. (17258631)
2007
13
RANKL in human periapical granuloma: possible involvement in periapical bone destruction. (16700737)
2006
14
Co-production of vascular endothelial cadherin and inducible nitric oxide synthase by endothelial cells in periapical granuloma. (16507070)
2006
15
Oral diagnosis. Interradicular radiolucency of maxilla. Periapical granuloma. (16161239)
2005
16
Intraneural epithelial islands associated with a periapical granuloma: a cause for concern? (12796887)
2003
17
Hydrogen peroxide and superoxide anion production by polymorphonuclear neutrophils in patients with chronic periapical granuloma, before and after surgical treatment. (11355101)
2001
18
Evaluation of immunoglobulin G synthesizing plasma cells in periapical granuloma and cyst. (11441800)
2001
19
The presence of chemokine receptor (CCR5, CXCR3, CCR3)-positive cells and chemokine (MCP1, MIP-1alpha, MIP-1beta, IP-10)-positive cells in human periapical granulomas. (11683586)
2001
20
Differential in situ distribution of interleukin-8, monocyte chemoattractant protein-1 and Rantes in human chronic periapical granuloma. (11155167)
2000
21
Cytotoxic T lymphocytes versus streptococcal colonization in periapical granulomas. (10425947)
1999
22
Focal cemento-osseous dysplasia in the maxilla mimicking periapical granuloma. (10442950)
1999
23
Interferon-gamma-producing cells and inducible nitric oxide synthase-producing cells in periapical granulomas. (9563799)
1998
24
Immune cells in periapical granuloma: morphological and immunohistochemical characterization. (1895036)
1991
25
Quantitative analysis of the immunocompetent cells in periapical granuloma: correlation with the histological characteristics of the lesions. (1974913)
1990
26
The role of acute phase proteins in the pathogenesis of chronic periapical granuloma]. (1698164)
1990
27
Acute phase proteins in patients with chronic periapical granuloma before and after surgical treatment. (3268759)
1988
28
Endodontic treatment and immunopathology of periapical granuloma in an AIDS patient. (2977755)
1988
29
In situ characterization of cells in periapical granuloma by monoclonal antibodies. (3477750)
1987
30
Bacteriological status of periapical granuloma. (6597195)
1984
31
Macrophages isolated from periapical granuloma: a scanning electron microscopic study. (6592531)
1984
32
Isolation and characterization of inflammatory cells from the human periapical granuloma. (6983538)
1982
33
Quantitative analysis of cellular composition of human periapical granuloma. (6938631)
1981
34
Reddening of the upper central incisors associated with periapical granuloma in lepromatous leprosy. (1063039)
1976
35
A colony of actinomyces-like organisms in a periapical granuloma. (4161341)
1966

Variations for Periapical Granuloma

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Expression for genes affiliated with Periapical Granuloma

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Search GEO for disease gene expression data for Periapical Granuloma.

Pathways for genes affiliated with Periapical Granuloma

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GO Terms for genes affiliated with Periapical Granuloma

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Biological processes related to Periapical Granuloma according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of T cell differentiationGO:00455829.9IL2, IL4
2extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.9IL2, IL4
3positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.9IL2, IL4
4positive regulation of B cell proliferationGO:00308909.9IL2, IL4
5positive regulation of homotypic cell-cell adhesionGO:00341129.8CCL5, TNFSF11
6positive regulation of isotype switching to IgG isotypesGO:00483049.7IL2, IL4
7positive regulation of phosphorylationGO:00423279.7CCL5, TNFSF11
8positive regulation of osteoclast differentiationGO:00456729.7CCL5, TNFSF11
9positive regulation of protein phosphorylationGO:00019349.5IL2, IL4
10monocyte chemotaxisGO:00025489.5CCL5, TNFSF11
11positive regulation of inflammatory responseGO:00507299.4CCL5, IL2
12positive regulation of T cell proliferationGO:00421029.0CCL5, IL2, IL4
13chemotaxisGO:00069358.7CCL5, IL4
14response to drugGO:00424938.6CCL5, IL4, MMP13
15immune responseGO:00069558.1CCL5, IL2, IL4, TNFSF11

Molecular functions related to Periapical Granuloma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00042229.5MMP13, MMP8

Sources for Periapical Granuloma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet