MCID: PRP002
MIFTS: 51

Periapical Granuloma malady

Oral diseases category

Summaries for Periapical Granuloma

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34MalaCards
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MalaCards: Periapical Granuloma, also known as apical granuloma, is related to leprosy and lepromatous leprosy. An important gene associated with Periapical Granuloma is MMP8 (matrix metallopeptidase 8 (neutrophil collagenase)), and among its related pathways are Matrix Metalloproteinases and IL2 signaling events mediated by PI3K. The compounds mcp 1 and gold sodium thiomalate have been mentioned in the context of this disorder. Affiliated tissues include endothelial, bone and colon, and related mouse phenotypes are no phenotypic analysis and vision/eye.

Aliases & Classifications for Periapical Granuloma

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9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Oral diseases


Aliases & Descriptions:

periapical granuloma 9 46 63
apical granuloma 9


External Ids:

Disease Ontology9 DOID:4617
SNOMED-CT59 196344002, 81407003
MeSH36 D010484

Related Diseases for Periapical Granuloma

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18GeneCards, 19GeneDecks
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Diseases related to Periapical Granuloma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1leprosy30.4IL2
2lepromatous leprosy30.2IL2, IL4, IFNG
3endotheliitis10.2
4farmer's lung10.1IL2RA
5bronchiolitis10.1CCL5, CCL3
6meningococcemia10.1CCL5
7proliferative glomerulonephritis10.1CCL2, CXCR3
8bacterial meningitis10.1CCL4, CCL3, MMP8
9intermediate uveitis10.1IL2RA, CCR5, CXCR3
10dengue disease10.1CCL4, CCL5, CCL3
11bronchiolitis obliterans10.1CXCR3, MMP8
12periodontal disease10.1TNFSF11, TNF
13pulpitis10.1IL1A
14mast-cell leukemia10.1CCL2, CCL5, CCL3
15vernal keratoconjunctivitis10.1IL4, CCL5, CXCR3
16polyostotic osteolytic dysplasia, hereditary expansile10.1TNFRSF11B, TNFSF11
17paget disease, juvenile10.1TNFRSF11B, TNFSF11
18central nervous system disease10.1CCR5, CCL2, CXCR3
19peripheral t-cell lymphoma10.1NOS2, IL2RA, CXCR3
20sjogren's syndrome10.1IL2RA, CCL3, CXCR3
21aggressive periodontitis10.1IL1A, MMP8
22pulmonary eosinophilia10.1IL4, CCL3
23contact dermatitis10.1IL1A, CXCR3
24pleurisy10.1IL2RA
25gastritis10.1NOS2, CCL5, CCL3
26osteosclerosis10.1TNFRSF11B, TNFSF11
27factor v leiden thrombophilia10.1CCL5, MMP8, MMP13, TNFSF11
28bone carcinoma10.1MMP13, TNFRSF11B, TNFSF11
29aortic valve stenosis10.1CCR5, TNFRSF11B, TNFSF11
30extrinsic allergic alveolitis10.1IL1A, CCL3
31cerebrovascular disease10.1CCL4, CCL3, MMP8, MMP13
32acute myocardial infarction10.1CDH5, CCL5, MMP8, TNFSF11
33idiopathic myopathy10.1IL1A, CCL2, CCL5
34peritonitis10.0CCL2, MMP8, TNF
35middle ear cholesteatoma10.0IL1A, TNFSF11
36glomerulonephritis10.0NOS2, CCL4, CCR5, CCL2
37aspergillosis10.0IFNG, CCL3
38aids dementia complex10.0NOS2, CCR5, TNF
39multiple myeloma10.0CCL3, TNFRSF11B, TNFSF11
40pulmonary fibrosis10.0CCL4, CCL2, CCL3, CXCR3, MMP13
41polymyositis10.0IL1A, CCR5, CCL3
42agammaglobulinemia10.0IL2, IL4
43osteoporosis10.0MMP8, MMP13, TNFRSF11B, TNFSF11
44periodontitis10.0IL1A, MMP8, TNFRSF11B
45secondary syphilis10.0CCL4, CCL3, TNFRSF11B, TNFSF11
46burkitt's lymphoma10.0IL4, CCL3, CXCR3
47oral lichen planus10.0IL1A, CCR5, CCL5, CXCR3
48mycosis fungoides10.0IL2RA, IL2, CXCR3
49tuberculoid leprosy10.0IL2RA, IFNG
50lupus nephritis10.0IL2RA, CCR5, CCL2, CCL5, CXCR3

Graphical network of the top 20 diseases related to Periapical Granuloma:



Diseases related to periapical granuloma

Symptoms for Periapical Granuloma

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Drugs & Therapeutics for Periapical Granuloma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Periapical Granuloma

Drug clinical trials:

Search ClinicalTrials for Periapical Granuloma

Search NIH Clinical Center for Periapical Granuloma

Search CenterWatch for Periapical Granuloma

Genetic Tests for Periapical Granuloma

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Anatomical Context for Periapical Granuloma

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34MalaCards
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MalaCards organs/tissues related to Periapical Granuloma:

34
Endothelial, Bone, Colon, T cells

Animal Models for Periapical Granuloma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Periapical Granuloma:

38 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.4TNF, TNFSF11, CCR5, IFNG, IL4, IL2
2MP:00053918.3TNF, CCL2, CCR5, IFNG, IL4, NOS2
3MP:00053908.1TNF, TNFSF11, TNFRSF11B, MMP13, CCL2, IFNG
4MP:00053828.1TNF, TNFSF11, TNFRSF11B, CCL2, IFNG, IL4
5MP:00053798.1TNF, TNFSF11, IFNG, IL4, IL2, HPSE
6MP:00053888.0TNF, CXCR3, IFNG, IL4, IL2, NOS2
7MP:00020067.9TNF, MMP8, CXCR3, CCL2, CCR5, IFNG
8MP:00107717.9TNF, TNFSF11, MMP13, CCL2, IFNG, IL4
9MP:00053707.8TNF, CCL2, CCR5, IFNG, IL4, IL2
10MP:00053897.5TNF, TNFSF11, CCL2, CCR5, IFNG, IL4
11MP:00053817.3TNF, CCL3, CCL2, CCR5, IFNG, IL4
12MP:00036317.1CCL3, CCL2, CCR5, IFNG, IL4, NOS2
13MP:00053866.9TNF, CCL3, CCL2, CCR5, IFNG, IL2
14MP:00053786.4CCL3, MMP13, TNFRSF11B, TNFSF11, TNF, CCL2
15MP:00053856.4TNF, TNFRSF11B, MMP13, CXCR3, CCL2, CCR5
16MP:00107686.2CCL3, CXCR3, TNFRSF11B, TNFSF11, TNF, CCL2
17MP:00053766.0CCL3, CXCR3, MMP13, TNFSF11, TNF, CCL2
18MP:00053846.0CCL3, CXCR3, MMP13, TNFRSF11B, TNF, CCL2
19MP:00053875.0TNF, CDH5, MDK, NOS2, IL1A, IL2RA
20MP:00053974.8TNF, MDK, NOS2, HPSE, IL1A, IL2RA

Publications for Periapical Granuloma

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53PubMed
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Articles related to Periapical Granuloma:

(show all 31)
idTitleAuthorsYear
1
Heparanase expression in periapical granulomas and radicular cysts. (22020734)
2013
2
Periapical granuloma associated with extracted teeth. (22037071)
2011
3
Midkine expression in human periapical granulomas. (21787488)
2011
4
Distinct Th1, Th2 and Treg cytokines balance in chronic periapical granulomas and radicular cysts. (20102461)
2010
5
T-helper cell type 17/regulatory T-cell immunoregulatory balance in human radicular cysts and periapical granulomas. (20478453)
2010
6
High matrix metalloproteinase activity is a hallmark of periapical granulomas. (19720222)
2009
7
Antrochoanal polyp derived from periapical granuloma. (18701055)
2008
8
Differential patterns of receptor activator of nuclear factor kappa B ligand/osteoprotegerin expression in human periapical granulomas: possible association with progressive or stable nature of the lesions. (18634923)
2008
9
Involvement of inducible nitric oxide synthase and receptor for advanced glycation end products in periapical granulomas. (17258631)
2007
10
RANKL in human periapical granuloma: possible involvement in periapical bone destruction. (16700737)
2006
11
Co-production of vascular endothelial cadherin and inducible nitric oxide synthase by endothelial cells in periapical granuloma. (16507070)
2006
12
Oral diagnosis. Interradicular radiolucency of maxilla. Periapical granuloma. (16161239)
2005
13
Intraneural epithelial islands associated with a periapical granuloma: a cause for concern? (12796887)
2003
14
Hydrogen peroxide and superoxide anion production by polymorphonuclear neutrophils in patients with chronic periapical granuloma, before and after surgical treatment. (11355101)
2001
15
Evaluation of immunoglobulin G synthesizing plasma cells in periapical granuloma and cyst. (11441800)
2001
16
The presence of chemokine receptor (CCR5, CXCR3, CCR3)-positive cells and chemokine (MCP1, MIP-1alpha, MIP-1beta, IP-10)-positive cells in human periapical granulomas. (11683586)
2001
17
Cytotoxic T lymphocytes versus streptococcal colonization in periapical granulomas. (10425947)
1999
18
Focal cemento-osseous dysplasia in the maxilla mimicking periapical granuloma. (10442950)
1999
19
Interferon-gamma-producing cells and inducible nitric oxide synthase-producing cells in periapical granulomas. (9563799)
1998
20
Immune cells in periapical granuloma: morphological and immunohistochemical characterization. (1895036)
1991
21
Quantitative analysis of the immunocompetent cells in periapical granuloma: correlation with the histological characteristics of the lesions. (1974913)
1990
22
The role of acute phase proteins in the pathogenesis of chronic periapical granuloma]. (1698164)
1990
23
Acute phase proteins in patients with chronic periapical granuloma before and after surgical treatment. (3268759)
1988
24
Endodontic treatment and immunopathology of periapical granuloma in an AIDS patient. (2977755)
1988
25
In situ characterization of cells in periapical granuloma by monoclonal antibodies. (3477750)
1987
26
Bacteriological status of periapical granuloma. (6597195)
1984
27
Macrophages isolated from periapical granuloma: a scanning electron microscopic study. (6592531)
1984
28
Isolation and characterization of inflammatory cells from the human periapical granuloma. (6983538)
1982
29
Quantitative analysis of cellular composition of human periapical granuloma. (6938631)
1981
30
Reddening of the upper central incisors associated with periapical granuloma in lepromatous leprosy. (1063039)
1976
31
A colony of actinomyces-like organisms in a periapical granuloma. (4161341)
1966

Variations for Periapical Granuloma

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Expression for genes affiliated with Periapical Granuloma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Periapical Granuloma

Search GEO for disease gene expression data for Periapical Granuloma.

Pathways for genes affiliated with Periapical Granuloma

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51PathCards, 39NCBI BioSystems Database, 54QIAGEN, 56Reactome, 31KEGG, 5Cell Signaling Technology, 55R&D Systems, 61Thomson Reuters
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Pathways related to Periapical Granuloma according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6MMP8, MMP13, TNF
2
Show member pathways
IL2 signaling events mediated by STAT539
9.5IL2RA, IL2, IL4
3
Show member pathways
9.4TNFRSF11B, TNFSF11, TNF
49.4IL2RA, IL2, IFNG
59.3IFNG, IL4, IL2
69.2IFNG, CCL2, TNF
79.2TNF, CCL2, IFNG
89.1TNFSF11, CCL5, IL4, IL2, IL2RA
9
Show member pathways
IL27-mediated signaling events39
9.1IL2, IFNG, TNF
109.1IFNG, IL4, IL2, IL2RA
11
Show member pathways
Type III interferon signaling39
9.1IFNG, IL4, IL2, IL2RA
129.1TNF, IL4, IL2RA, IL1A
13
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
9.0TNF, IL4, IL2, IL2RA
14
Show member pathways
8.9IL1A, IFNG, CCR5, TNF
158.9CCL2, CCL3, TNF
168.9NOS2, IL1A, IFNG, TNF
17
Show member pathways
Immune response MIF in innate immunity response61
8.9TNF, IFNG, IL1A, NOS2
18
Show member pathways
Ras signaling in the CD4+ TCR pathway39
8.8IL2RA, IL2, IFNG, TNF
198.8NOS2, IL2, IFNG, TNF
20
Show member pathways
Immune response CD16 signaling in NK cells61
8.8TNF, IFNG, IL4, IL2
21
Show member pathways
8.8CCL2, IL4, IL2, IL2RA, MDK
22
Show member pathways
Apoptosis and survival TNFR1 signaling pathway61
TWEAK Signaling Pathway39
Apoptosis Modulation by HSP7039
HIV-1 Nef- Negative effector of Fas and TNF-alpha39
8.7TNF, TNFSF11, TNFRSF11B, CCL5, CCL2, CCR5
23
Show member pathways
8.6CCL4, CCR5, CCL5, CCL3
24
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
8.6TNF, IFNG, IL4, IL1A, NOS2
25
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
8.6TNF, CCL2, IFNG, IL2, NOS2
26
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
8.6TNF, IFNG, IL4, IL2, IL2RA
278.6TNF, TNFSF11, TNFRSF11B, IFNG, IL1A
288.6TNF, TNFSF11, TNFRSF11B, IFNG, IL1A
298.4TNF, IFNG, IL4, IL2, IL1A
308.4TNF, IFNG, IL4, IL2, IL1A
31
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
8.2TNF, CCR5, IFNG, IL4, IL2, IL1A
32
Show member pathways
8.2TNF, IFNG, IL4, IL2, IL2RA, IL1A
33
Show member pathways
8.2TNF, IFNG, IL4, IL2, IL2RA, IL1A
34
Show member pathways
8.1CXCR3, CCL3, CCL5, CCL2, CCR5, CCL4
35
Show member pathways
8.1CXCR3, CCL3, CCL5, CCL2, CCR5, CCL4
36
Show member pathways
8.1CXCR3, CCL3, CCL5, CCL2, CCR5, CCL4
37
Show member pathways
7.9CCL3, CCL4, IFNG, IL1A, NOS2
38
Show member pathways
7.9TNF, CCR5, IFNG, IL4, IL2, IL1A
397.9TNF, CCL2, IFNG, IL4, IL2, IL1A
40
Show member pathways
7.7TNF, CCL5, CCL2, IFNG, IL4, IL2
417.6TNF, TNFSF11, CCL3, CCL5, CCL2, IFNG
42
Show member pathways
7.5MMP13, MMP8, CXCR3, CCL3, CCL5, CCL2
43
Show member pathways
7.4TNF, CCL3, CCL4, IFNG, IL2, IL2RA
44
Show member pathways
Immune response IL 12 induced IFN gamma production61
7.1CCL3, CCR5, CCL4, IFNG, IL4, IL2
45
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
6.9TNF, CCL3, CCL5, CCL2, CCL4, IFNG
46
Show member pathways
5.8TNF, CCL3, CCL5, CCL2, CCL4, IFNG
47
Show member pathways
5.6IL2, IL2RA, IL1A, MDK, IL4, CCL4
48
Show member pathways
5.6TNF, TNFSF11, CXCR3, CCL3, CCL5, CCL2
49
Show member pathways
5.3IL1A, IL2RA, TNF, TNFSF11, TNFRSF11B, CXCR3
50
Show member pathways
5.3TNF, TNFSF11, CXCR3, CCL3, CCL5, CCL2

Compounds for genes affiliated with Periapical Granuloma

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46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB, 3BitterDB
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Compounds related to Periapical Granuloma according to GeneCards/GeneDecks:

(show top 50)    (show all 246)
idCompoundScoreTop Affiliating Genes
1mcp 1468.6CCL3, CCL5, CCL2, CCL4, CXCR3
2gold sodium thiomalate468.5IFNG, IL1A, IL2RA, IL2, TNF
3infliximab46 52 1210.5TNFRSF11B, TNFSF11, CXCR3, TNF, IFNG, IL4
4polymyxin b468.4IL1A, IL4, IFNG, CCL2, TNFRSF11B, TNFSF11
5mdms468.2CCL3, CCL4, CCL2, CCL5, CCR5
6pentoxifylline46 129.2IL2, IL1A, IL4, IFNG, TNF, IL2RA
7larc468.2IL1A, CCL4, CCR5, CCL2, CCL5, CCL3
8thalidomide46 52 62 1211.2IL1A, IL2RA, IL2, IFNG, CCL5, TNFRSF11B
9ccl446 309.1CCL4, CCR5, CCL2, CCL5, CCL3, CXCR3
10ivig468.0TNF, CCR5, CCL4, IFNG, IL4, IL2RA
11toxin-1468.0IL2, CCL3, CCL4, TNF, CCL2
12ribavirin46 52 129.8IL4, IL2, IFNG, CCR5, CCL3, CXCR3
13calcitriol46 62 25 1210.7TNF, IL2RA, IL1A, IFNG, IL4, TNFSF11
14mip 1alpha467.7IL4, CCL4, CCR5, CCL2, CCL5, CCL3
15polyinosinic-polycytidylic acid467.7IL4, IL1A, IL2, IFNG, CCL3, NOS2
16pdtc467.7IL4, IFNG, CCL2, CCL5, CCL3, TNF
17neopterin467.6IL1A, IL2RA, IL2, IL4, CCL3, TNF
18ly294002467.6CCL5, TNF, TNFSF11, NOS2, IL4, CCL2
19herbimycin a46 628.6MMP13, TNF, CCL2, IFNG, NOS2, HPSE
20gm-csf46 308.6IL1A, IL2, IL4, IFNG, CCL2, CCL5
21heparan sulfate46 258.5CCL5, CCL4, MDK, CCL3, TNFRSF11B, TNFSF11
22groalpha467.5CCL5, CCL3, CXCR3, MMP13, TNF, CCL2
23triptolide467.3NOS2, IL2, IFNG, CCL4, CCL5, CCL3
24ccl346 308.2CCL3, CXCR3, TNF, IL1A, IFNG, CCL4
25endotoxin467.2NOS2, IL1A, IFNG, CCL4, CCL2, CCL5
26prednisolone46 30 129.2TNF, TNFRSF11B, CCL3, CCL4, IFNG, IL2
27simvastatin46 52 62 30 25 1212.1IL1A, IL4, IFNG, CCL4, CCR5, CCL2
28hydrocortisone46 3 62 1210.0CDH5, IL1A, IL2, IL4, IFNG, CCL5
29actinomycin d467.0CCL2, TNF, NOS2, MMP13, CCL3, CCR5
30ionomycin467.0IL1A, IL2RA, IL2, IL4, IFNG, CCL4
31thymidine46 258.0CXCR3, TNF, MMP13, CCL3, IFNG, IL2RA
32tacrolimus46 52 128.9IL2RA, IL2, IL4, IFNG, CCL4, CCL5
33tarc466.9CCR5, CCL2, CCL5, CCL3, CXCR3, TNF
34genistein46 30 62 3 25 1211.9MMP8, CCL5, CCL2, IFNG, IL2, IL2RA
35oxygen46 257.8CXCR3, CCL3, CCL4, HPSE, NOS2, CDH5
36cysteine466.8TNFSF11, CCL3, CCL5, TNFRSF11B, MMP13, CCL4
37heparin46 30 25 129.5TNFSF11, TNFRSF11B, MMP13, CXCR3, CCL3, CCL5
38histamine46 30 258.4IL4, IFNG, CCL4, CCR5, CCL2, CCL5
39sb 20358046 627.3CCL5, CCL3, MMP13, TNFRSF11B, TNFSF11, TNF
40il 10466.3CCL4, CCR5, CCL2, CCL5, CCL3, CXCR3
41retinoic acid46 257.1CCR5, CCL3, MMP8, MMP13, TNF, CCL5
42cyclosporin a46 30 628.0IL1A, TNF, IL2RA, IL2, IL4, IFNG
43indomethacin46 30 62 128.9CCL5, CCL3, MMP13, TNFRSF11B, TNFSF11, TNF
44serine465.9CCL3, IL2, CCL4, MMP8, HPSE, TNFSF11
45cycloheximide465.8TNFRSF11B, CCL4, IFNG, IL4, IL1A, IL2
46nitric oxide46 25 127.6TNF, TNFSF11, TNFRSF11B, MMP13, MMP8, CXCR3
47rantes465.5TNFSF11, TNF, IL2RA, IL2, IL4, IFNG
48dexamethasone46 52 30 128.2TNF, TNFSF11, TNFRSF11B, MMP13, CXCR3, CCL3
49pge2465.0NOS2, CCR5, CCL2, CCL5, CCL4, IFNG
50vegf464.6IL2RA, IL1A, HPSE, NOS2, CDH5, IL2

GO Terms for genes affiliated with Periapical Granuloma

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17Gene Ontology
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Cellular components related to Periapical Granuloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.5CXCR3, CCR5, IFNG, IL4, IL2RA, TNF
2extracellular spaceGO:0056155.3IL2, IL4, IFNG, CCL4, CCL2, CCL5
3extracellular regionGO:0055764.9MDK, TNF, HPSE, IL1A, IL2, IFNG

Biological processes related to Periapical Granuloma according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of homotypic cell-cell adhesionGO:03411210.3TNFSF11, CCL5
2regulation of T cell homeostatic proliferationGO:04601310.2IL2, IL2RA
3chemokine-mediated signaling pathwayGO:07009810.1CCL5, CCL2, CCR5
4positive regulation of killing of cells of other organismGO:05171210.1IFNG, NOS2
5innate immune response in mucosaGO:00222710.0IL4, NOS2
6positive regulation of activated T cell proliferationGO:0421049.9IL4, IL2, IL2RA
7positive regulation of hair follicle developmentGO:0517989.9TNF, HPSE
8positive regulation of vitamin D biosynthetic processGO:0605579.9TNF, IFNG
9positive regulation of calcidiol 1-monooxygenase activityGO:0605599.8TNF, IFNG
10positive regulation of T cell proliferationGO:0421029.8CCL5, IFNG, IL4
11signalingGO:0230529.8CCL3, CCR5
12positive regulation of isotype switching to IgG isotypesGO:0483049.8IFNG, IL4, IL2
13extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.7IL4, IL2, IL1A
14cellular response to lipopolysaccharideGO:0712229.7CCL2, CCR5, IFNG, NOS2
15positive regulation of osteoclast differentiationGO:0456729.7IFNG, TNFSF11, TNF
16positive regulation of MHC class II biosynthetic processGO:0453489.6IL4, IFNG
17positive regulation of chemokine biosynthetic processGO:0450809.6TNF, IFNG, IL4
18T cell chemotaxisGO:0108189.6CXCR3, CCL3
19astrocyte cell migrationGO:0436159.6CCL3, CCL2
20release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:0148089.6CCL3, CCR5
21macrophage chemotaxisGO:0482469.6CCL2, CCL5, CCL3
22cellular response to interleukin-1GO:0713479.5CCL2, CCL5, CCL3
23humoral immune responseGO:0069599.5IFNG, CCL2, TNF
24cell surface receptor signaling pathwayGO:0071669.5IL2RA, IFNG, CCR5, CCL2, CXCR3
25cellular response to tumor necrosis factorGO:0713569.4CCL2, CCL5, CCL3
26response to cholesterolGO:0707239.4CCR5, CCL3
27monocyte chemotaxisGO:0025489.4CCL2, CCL5, CCL3, TNFSF11
28cytokine-mediated signaling pathwayGO:0192219.4TNFSF11, CCL2, IFNG, IL1A
29cellular response to interferon-gammaGO:0713469.4NOS2, CCL2, CCL5, CCL3
30neutrophil chemotaxisGO:0305939.3IFNG, CCL2, CCL3
31positive regulation of natural killer cell chemotaxisGO:20005039.3CCL4, CCL5, CCL3
32negative regulation by host of viral transcriptionGO:0439229.2CCL3, CCL5, CCL4
33positive regulation of calcium ion transportGO:0519289.2CCL4, CCL5, CCL3
34cell activationGO:0017759.1CCL3, TNF
35calcium-mediated signalingGO:0197229.1CCR5, CCL3, CXCR3, TNF
36lipopolysaccharide-mediated signaling pathwayGO:0316639.1TNF, CCL3, CCL5, CCL2
37protein kinase B signalingGO:0434919.1TNF, CCL3, CCL5, CCL2
38lymphocyte chemotaxisGO:0482479.1CCL2, CCL3
39cellular response to organic cyclic compoundGO:0714079.1TNF, CCL3, CCL5, CCL2
40response to virusGO:0096159.0TNF, CCL5, CCL4, IFNG
41positive regulation of protein kinase B signalingGO:0518979.0TNF, TNFSF11, CCL3, HPSE
42chemotaxisGO:0069358.9CXCR3, CCL3, CCL5, CCL2, CCR5, IL4
43response to toxic substanceGO:0096368.9CCL3, CCL5, CCL4
44MAPK cascadeGO:0001658.9TNF, CCL3, CCL5, CCL2, CCR5
45apoptotic processGO:0069158.7TNF, TNFRSF11B, CXCR3, IFNG, IL2RA, IL1A
46cell-cell signalingGO:0072678.6CCL3, CCL5, CCR5, CCL4, IL2
47immune responseGO:0069558.5TNFSF11, CCR5, CCL4, IL4, IL2, IL2RA
48response to drugGO:0424938.5TNF, TNFRSF11B, CCL2, IFNG, IL4, MDK
49positive regulation of transcription from RNA polymerase II promoterGO:0459448.4TNF, TNFSF11, CXCR3, IFNG, IL4, IL2
50inflammatory responseGO:0069547.4NOS2, TNF, CXCR3, CCL3, CCL5, CCL2

Molecular functions related to Periapical Granuloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00495010.1CCR5, CXCR3
2phospholipase activator activityGO:0160049.1CCL5, CCL3
3CCR5 chemokine receptor bindingGO:0317308.9CCL3, CCL5, CCL4
4CCR1 chemokine receptor bindingGO:0317268.8CCL3, CCL5, CCL4
5chemokine activityGO:0080098.5CCL3, CCL5, CCL2, CCL4
6cytokine activityGO:0051257.4IL1A, TNF, TNFSF11, TNFRSF11B, CCL4, IFNG

Products for genes affiliated with Periapical Granuloma

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  • Antibodies
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Sources for Periapical Granuloma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet