MCID: PRP002
MIFTS: 53

Periapical Granuloma malady

Oral diseases category
Download this MalaCard

Summaries for Periapical Granuloma

About this section


Fully expand this MalaCard
MalaCards based summary: Periapical Granuloma, also known as apical granuloma, is related to leprosy and lepromatous leprosy. An important gene associated with Periapical Granuloma is MMP8 (matrix metallopeptidase 8 (neutrophil collagenase)), and among its related pathways are Matrix Metalloproteinases and IL2 signaling events mediated by PI3K. The compounds mcp 1 and gold sodium thiomalate have been mentioned in the context of this disorder. Affiliated tissues include endothelial, bone and colon, and related mouse phenotypes are no phenotypic analysis and vision/eye.

Aliases & Classifications for Periapical Granuloma

About this section
Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH
See all sources

Periapical Granuloma, Aliases & Descriptions:

Name: Periapical Granuloma 8 44 62
 
Apical Granuloma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Oral diseases


External Ids:

Disease Ontology8 DOID:4617
SNOMED-CT57 196344002, 81407003
MeSH34 D010484

Related Diseases for Periapical Granuloma

About this section

Diseases related to Periapical Granuloma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1leprosy30.9IL2
2lepromatous leprosy30.1IL2, IL4, IFNG
3farmer's lung10.6IL2RA
4bronchiolitis10.5CCL5, CCL3
5meningococcemia10.5CCL5
6proliferative glomerulonephritis10.4CCL2, CXCR3
7bacterial meningitis10.4CCL4, CCL3, MMP8
8pars planitis10.4IL2RA, CCR5, CXCR3
9dengue disease10.4CCL4, CCL5, CCL3
10bronchiolitis obliterans10.4CXCR3, MMP8
11periodontal disease10.4TNFSF11, TNF
12pulpitis10.4IL1A
13systemic mastocytosis10.4CCL2, CCL5, CCL3
14vernal keratoconjunctivitis10.4IL4, CCL5, CXCR3
15polyostotic osteolytic dysplasia, hereditary expansile10.3TNFRSF11B, TNFSF11
16paget disease, juvenile10.3TNFRSF11B, TNFSF11
17central nervous system disease10.3CCR5, CCL2, CXCR3
18peripheral t-cell lymphoma10.3NOS2, IL2RA, CXCR3
19sjogren's syndrome10.3IL2RA, CCL3, CXCR3
20aggressive periodontitis10.3IL1A, MMP8
21pulmonary eosinophilia10.3IL4, CCL3
22contact dermatitis10.3IL1A, CXCR3
23pleurisy10.3IL2RA
24gastritis10.3NOS2, CCL5, CCL3
25osteosclerosis10.3TNFRSF11B, TNFSF11
26factor v leiden thrombophilia10.3CCL5, MMP8, MMP13, TNFSF11
27bone cancer10.3MMP13, TNFRSF11B, TNFSF11
28aortic valve stenosis10.3CCR5, TNFRSF11B, TNFSF11
29extrinsic allergic alveolitis10.3IL1A, CCL3
30cerebrovascular disease10.3CCL4, CCL3, MMP8, MMP13
31acute myocardial infarction10.2CDH5, CCL5, MMP8, TNFSF11
32idiopathic myopathy10.2IL1A, CCL2, CCL5
33peritonitis10.2CCL2, MMP8, TNF
34middle ear cholesteatoma10.2IL1A, TNFSF11
35aspergillosis10.2IFNG, CCL3
36glomerulonephritis10.2NOS2, CCL4, CCR5, CCL2
37aids dementia complex10.2NOS2, CCR5, TNF
38multiple myeloma10.2CCL3, TNFRSF11B, TNFSF11
39pulmonary fibrosis10.2CCL4, CCL2, CCL3, CXCR3, MMP13
40polymyositis10.2IL1A, CCR5, CCL3
41bruton-type agammaglobulinemia10.2IL2, IL4
42osteoporosis10.2MMP8, MMP13, TNFRSF11B, TNFSF11
43periodontitis10.2IL1A, MMP8, TNFRSF11B
44secondary syphilis10.2CCL4, CCL3, TNFRSF11B, TNFSF11
45burkitt's lymphoma10.2IL4, CCL3, CXCR3
46oral lichen planus10.2IL1A, CCR5, CCL5, CXCR3
47mycosis fungoides10.2IL2RA, IL2, CXCR3
48tuberculoid leprosy10.2IL2RA, IFNG
49lupus nephritis10.2IL2RA, CCR5, CCL2, CCL5, CXCR3
50leishmaniasis10.2IL4, IFNG

Graphical network of the top 20 diseases related to Periapical Granuloma:



Diseases related to periapical granuloma

Symptoms for Periapical Granuloma

About this section

Drugs & Therapeutics for Periapical Granuloma

About this section

Drug clinical trials:

Search ClinicalTrials for Periapical Granuloma

Search NIH Clinical Center for Periapical Granuloma

Genetic Tests for Periapical Granuloma

About this section

Anatomical Context for Periapical Granuloma

About this section

MalaCards organs/tissues related to Periapical Granuloma:

32
Endothelial, Bone, Colon, Monocytes, T cells, Neutrophil

Animal Models for Periapical Granuloma or affiliated genes

About this section

MGI Mouse Phenotypes related to Periapical Granuloma:

36 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.4TNF, TNFSF11, CCR5, IFNG, IL4, IL2
2MP:00053918.3TNF, CCL2, CCR5, IFNG, IL4, NOS2
3MP:00053908.1TNF, TNFSF11, TNFRSF11B, MMP13, CCL2, IFNG
4MP:00053828.1TNF, TNFSF11, TNFRSF11B, CCL2, IFNG, IL4
5MP:00053798.1TNF, TNFSF11, IFNG, IL4, IL2, HPSE
6MP:00053888.0TNF, CXCR3, IFNG, IL4, IL2, NOS2
7MP:00020067.9TNF, MMP8, CXCR3, CCL2, CCR5, IFNG
8MP:00107717.9TNF, TNFSF11, MMP13, CCL2, IFNG, IL4
9MP:00053707.8TNF, CCL2, CCR5, IFNG, IL4, IL2
10MP:00053897.5TNF, TNFSF11, CCL2, CCR5, IFNG, IL4
11MP:00053817.3TNF, CCL3, CCL2, CCR5, IFNG, IL4
12MP:00036317.1CCL3, CCL2, CCR5, IFNG, IL4, NOS2
13MP:00053866.9TNF, CCL3, CCL2, CCR5, IFNG, IL2
14MP:00053786.4CCL3, MMP13, TNFRSF11B, TNFSF11, TNF, CCL2
15MP:00053856.4TNF, TNFRSF11B, MMP13, CXCR3, CCL2, CCR5
16MP:00107686.2CCL3, CXCR3, TNFRSF11B, TNFSF11, TNF, CCL2
17MP:00053766.0CCL3, CXCR3, MMP13, TNFSF11, TNF, CCL2
18MP:00053846.0CCL3, CXCR3, MMP13, TNFRSF11B, TNF, CCL2
19MP:00053875.0TNF, CDH5, MDK, NOS2, IL1A, IL2RA
20MP:00053974.8TNF, MDK, NOS2, HPSE, IL1A, IL2RA

Publications for Periapical Granuloma

About this section

Articles related to Periapical Granuloma:

(show all 34)
idTitleAuthorsYear
1
Expression and immunohistochemical localization of leptin receptor in human periapical granuloma. (25081278)
2014
2
Heparanase expression in periapical granulomas and radicular cysts. (22020734)
2013
3
Oral pathology quiz #81. Case number 4. Dental (periapical) granuloma. (24597181)
2013
4
Periapical granuloma associated with extracted teeth. (22037071)
2011
5
Midkine expression in human periapical granulomas. (21787488)
2011
6
Distinct Th1, Th2 and Treg cytokines balance in chronic periapical granulomas and radicular cysts. (20102461)
2010
7
T-helper cell type 17/regulatory T-cell immunoregulatory balance in human radicular cysts and periapical granulomas. (20478453)
2010
8
High matrix metalloproteinase activity is a hallmark of periapical granulomas. (19720222)
2009
9
Antrochoanal polyp derived from periapical granuloma. (18701055)
2008
10
Differential patterns of receptor activator of nuclear factor kappa B ligand/osteoprotegerin expression in human periapical granulomas: possible association with progressive or stable nature of the lesions. (18634923)
2008
11
Involvement of inducible nitric oxide synthase and receptor for advanced glycation end products in periapical granulomas. (17258631)
2007
12
RANKL in human periapical granuloma: possible involvement in periapical bone destruction. (16700737)
2006
13
Co-production of vascular endothelial cadherin and inducible nitric oxide synthase by endothelial cells in periapical granuloma. (16507070)
2006
14
Oral diagnosis. Interradicular radiolucency of maxilla. Periapical granuloma. (16161239)
2005
15
Intraneural epithelial islands associated with a periapical granuloma: a cause for concern? (12796887)
2003
16
Hydrogen peroxide and superoxide anion production by polymorphonuclear neutrophils in patients with chronic periapical granuloma, before and after surgical treatment. (11355101)
2001
17
Evaluation of immunoglobulin G synthesizing plasma cells in periapical granuloma and cyst. (11441800)
2001
18
The presence of chemokine receptor (CCR5, CXCR3, CCR3)-positive cells and chemokine (MCP1, MIP-1alpha, MIP-1beta, IP-10)-positive cells in human periapical granulomas. (11683586)
2001
19
Differential in situ distribution of interleukin-8, monocyte chemoattractant protein-1 and Rantes in human chronic periapical granuloma. (11155167)
2000
20
Cytotoxic T lymphocytes versus streptococcal colonization in periapical granulomas. (10425947)
1999
21
Focal cemento-osseous dysplasia in the maxilla mimicking periapical granuloma. (10442950)
1999
22
Interferon-gamma-producing cells and inducible nitric oxide synthase-producing cells in periapical granulomas. (9563799)
1998
23
Immune cells in periapical granuloma: morphological and immunohistochemical characterization. (1895036)
1991
24
Quantitative analysis of the immunocompetent cells in periapical granuloma: correlation with the histological characteristics of the lesions. (1974913)
1990
25
The role of acute phase proteins in the pathogenesis of chronic periapical granuloma]. (1698164)
1990
26
Acute phase proteins in patients with chronic periapical granuloma before and after surgical treatment. (3268759)
1988
27
Endodontic treatment and immunopathology of periapical granuloma in an AIDS patient. (2977755)
1988
28
In situ characterization of cells in periapical granuloma by monoclonal antibodies. (3477750)
1987
29
Bacteriological status of periapical granuloma. (6597195)
1984
30
Macrophages isolated from periapical granuloma: a scanning electron microscopic study. (6592531)
1984
31
Isolation and characterization of inflammatory cells from the human periapical granuloma. (6983538)
1982
32
Quantitative analysis of cellular composition of human periapical granuloma. (6938631)
1981
33
Reddening of the upper central incisors associated with periapical granuloma in lepromatous leprosy. (1063039)
1976
34
A colony of actinomyces-like organisms in a periapical granuloma. (4161341)
1966

Variations for Periapical Granuloma

About this section

Expression for genes affiliated with Periapical Granuloma

About this section
Expression patterns in normal tissues for genes affiliated with Periapical Granuloma

Search GEO for disease gene expression data for Periapical Granuloma.

Pathways for genes affiliated with Periapical Granuloma

About this section

Pathways related to Periapical Granuloma according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6TNF, MMP8, MMP13
2
Show member pathways
IL2 signaling events mediated by STAT537
9.5IL2RA, IL4, IL2
3
Show member pathways
9.4TNF, TNFRSF11B, TNFSF11
49.4IFNG, IL2RA, IL2
59.3IL4, IFNG, IL2
69.2TNF, IFNG, CCL2
79.2CCL2, IFNG, TNF
89.1IL2RA, IL2, CCL5, IL4, TNFSF11
9
Show member pathways
IL27-mediated signaling events37
9.1IFNG, TNF, IL2
109.1IFNG, IL4, IL2, IL2RA
11
Show member pathways
Type III interferon signaling37
9.1IL4, IFNG, IL2, IL2RA
129.1IL1A, TNF, IL4, IL2RA
13
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.0TNF, IL2RA, IL4, IL2
14
Show member pathways
8.9TNF, IFNG, IL1A, CCR5
158.9CCL2, TNF, CCL3
168.9NOS2, IFNG, TNF, IL1A
17
Show member pathways
Immune response MIF in innate immunity response60
8.9TNF, NOS2, IL1A, IFNG
18
Show member pathways
Ras signaling in the CD4+ TCR pathway37
8.8IL2, TNF, IFNG, IL2RA
198.8IFNG, IL2, TNF, NOS2
20
Show member pathways
Immune response CD16 signaling in NK cells60
8.8IFNG, IL4, IL2, TNF
21
Show member pathways
8.8IL4, IL2, CCL2, IL2RA, MDK
22
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
8.7TNF, TNFSF11, TNFRSF11B, CCL5, CCR5, CCL2
23
Show member pathways
8.6CCL3, CCL4, CCR5, CCL5
24
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.6TNF, IL4, IL1A, NOS2, IFNG
25
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.6NOS2, IL2, IFNG, CCL2, TNF
26
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
8.6IL2RA, IL2, IL4, IFNG, TNF
278.6TNFRSF11B, TNFSF11, IFNG, IL1A, TNF
288.6IL1A, TNFRSF11B, TNFSF11, TNF, IFNG
298.4IL2, TNF, IL4, IFNG, IL1A
308.4IFNG, IL1A, IL4, TNF, IL2
31
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.2IL2, IL1A, CCR5, IL4, IFNG, TNF
32
Show member pathways
8.2IL2RA, IL1A, IL2, IL4, IFNG, TNF
33
Show member pathways
8.2IL2RA, TNF, IFNG, IL4, IL2, IL1A
34
Show member pathways
8.1CXCR3, CCL2, CCR5, CCL4, CCL5, CCL3
35
Show member pathways
8.1CCL2, CCR5, CCL5, CCL4, CCL3, CXCR3
36
Show member pathways
8.1CCL3, CCL5, CCR5, CCL4, CCL2, CXCR3
37
Show member pathways
7.9IFNG, CCL3, CCL4, NOS2, IL1A
38
Show member pathways
7.9IL1A, IL4, CCR5, IFNG, IL2, TNF
397.9TNF, IL4, NOS2, IL1A, IL2, IFNG
40
Show member pathways
7.7TNF, CCL2, IL2RA, IL1A, CCL5, IFNG
417.6TNF, TNFSF11, CCL3, CCL2, IFNG, IL1A
42
Show member pathways
7.5CXCR3, CDH5, CCL5, MMP8, MMP13, CCR5
43
Show member pathways
7.4IL2, IFNG, IL2RA, CCL3, CCL4, TNF
44
Show member pathways
Immune response IL 12 induced IFN gamma production60
7.1CCL4, CCL3, CCR5, IFNG, IL4, IL2
45
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
6.9NOS2, IL2, IFNG, CCL4, CCL2, CCL5
46
Show member pathways
5.8MDK, TNF, CCL4, IL4, IL2, IL2RA
47
Show member pathways
5.6MDK, CXCR3, TNFSF11, TNF, IL1A, IL2RA
48
Show member pathways
5.6IL1A, TNF, TNFSF11, CXCR3, CCL3, CCL5
49
Show member pathways
5.3IL1A, IL2RA, IL2, IL4, TNF, TNFSF11
50
Show member pathways
5.3TNF, TNFSF11, CXCR3, CCL3, CCL5, CCL2

Compounds for genes affiliated with Periapical Granuloma

About this section

Compounds related to Periapical Granuloma according to GeneCards/GeneDecks:

(show top 50)    (show all 246)
idCompoundScoreTop Affiliating Genes
1mcp 1448.6CCL3, CCL5, CCL2, CCL4, CXCR3
2gold sodium thiomalate448.5IFNG, IL1A, IL2RA, IL2, TNF
3infliximab44 50 1110.5TNFRSF11B, TNFSF11, CXCR3, TNF, IFNG, IL4
4polymyxin b448.4IL1A, IL4, IFNG, CCL2, TNFRSF11B, TNFSF11
5mdms448.2CCL3, CCL4, CCL2, CCL5, CCR5
6pentoxifylline44 119.2IL2, IL1A, IL4, IFNG, TNF, IL2RA
7larc448.2IL1A, CCL4, CCR5, CCL2, CCL5, CCL3
8thalidomide44 50 61 1111.2IL1A, IL2RA, IL2, IFNG, CCL5, TNFRSF11B
9ccl444 289.1CCL4, CCR5, CCL2, CCL5, CCL3, CXCR3
10ivig448.0TNF, CCR5, CCL4, IFNG, IL4, IL2RA
11toxin-1448.0IL2, CCL3, CCL4, TNF, CCL2
12ribavirin44 50 119.8IL4, IL2, IFNG, CCR5, CCL3, CXCR3
13calcitriol44 61 24 1110.7TNF, IL2RA, IL1A, IFNG, IL4, TNFSF11
14mip 1alpha447.7IL4, CCL4, CCR5, CCL2, CCL5, CCL3
15polyinosinic-polycytidylic acid447.7IL4, IL1A, IL2, IFNG, CCL3, NOS2
16pdtc447.7IL4, IFNG, CCL2, CCL5, CCL3, TNF
17neopterin447.6IL1A, IL2RA, IL2, IL4, CCL3, TNF
18ly294002447.6CCL5, TNF, TNFSF11, NOS2, IL4, CCL2
19herbimycin a44 618.6MMP13, TNF, CCL2, IFNG, NOS2, HPSE
20gm-csf44 288.6IL1A, IL2, IL4, IFNG, CCL2, CCL5
21heparan sulfate44 248.5CCL5, CCL4, MDK, CCL3, TNFRSF11B, TNFSF11
22groalpha447.5CCL5, CCL3, CXCR3, MMP13, TNF, CCL2
23triptolide447.3NOS2, IL2, IFNG, CCL4, CCL5, CCL3
24ccl344 288.2CCL3, CXCR3, TNF, IL1A, IFNG, CCL4
25endotoxin447.2NOS2, IL1A, IFNG, CCL4, CCL2, CCL5
26prednisolone44 28 119.2TNF, TNFRSF11B, CCL3, CCL4, IFNG, IL2
27simvastatin44 50 61 28 24 1112.1IL1A, IL4, IFNG, CCL4, CCR5, CCL2
28hydrocortisone44 2 61 1110.0CDH5, IL1A, IL2, IL4, IFNG, CCL5
29actinomycin d447.0CCL2, TNF, NOS2, MMP13, CCL3, CCR5
30ionomycin447.0IL1A, IL2RA, IL2, IL4, IFNG, CCL4
31thymidine44 248.0CXCR3, TNF, MMP13, CCL3, IFNG, IL2RA
32tacrolimus44 50 118.9IL2RA, IL2, IL4, IFNG, CCL4, CCL5
33tarc446.9CCR5, CCL2, CCL5, CCL3, CXCR3, TNF
34genistein44 28 61 2 24 1111.9MMP8, CCL5, CCL2, IFNG, IL2, IL2RA
35oxygen44 247.8CXCR3, CCL3, CCL4, HPSE, NOS2, CDH5
36cysteine446.8TNFSF11, CCL3, CCL5, TNFRSF11B, MMP13, CCL4
37heparin44 28 24 119.5TNFSF11, TNFRSF11B, MMP13, CXCR3, CCL3, CCL5
38histamine44 28 248.4IL4, IFNG, CCL4, CCR5, CCL2, CCL5
39sb 20358044 617.3CCL5, CCL3, MMP13, TNFRSF11B, TNFSF11, TNF
40il 10446.3CCL4, CCR5, CCL2, CCL5, CCL3, CXCR3
41retinoic acid44 247.1CCR5, CCL3, MMP8, MMP13, TNF, CCL5
42cyclosporin a44 28 618.0IL1A, TNF, IL2RA, IL2, IL4, IFNG
43indomethacin44 28 61 118.9CCL5, CCL3, MMP13, TNFRSF11B, TNFSF11, TNF
44serine445.9CCL3, IL2, CCL4, MMP8, HPSE, TNFSF11
45cycloheximide445.8TNFRSF11B, CCL4, IFNG, IL4, IL1A, IL2
46nitric oxide44 24 117.6TNF, TNFSF11, TNFRSF11B, MMP13, MMP8, CXCR3
47rantes445.5TNFSF11, TNF, IL2RA, IL2, IL4, IFNG
48dexamethasone44 50 28 118.2TNF, TNFSF11, TNFRSF11B, MMP13, CXCR3, CCL3
49pge2445.0NOS2, CCR5, CCL2, CCL5, CCL4, IFNG
50vegf444.6IL2RA, IL1A, HPSE, NOS2, CDH5, IL2

GO Terms for genes affiliated with Periapical Granuloma

About this section

Cellular components related to Periapical Granuloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.5CXCR3, CCR5, IFNG, IL4, IL2RA, TNF
2extracellular spaceGO:0056155.3IL2, IL4, IFNG, CCL4, CCL2, CCL5
3extracellular regionGO:0055764.9MDK, TNF, HPSE, IL1A, IL2, IFNG

Biological processes related to Periapical Granuloma according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of homotypic cell-cell adhesionGO:03411210.3CCL5, TNFSF11
2regulation of T cell homeostatic proliferationGO:04601310.2IL2, IL2RA
3chemokine-mediated signaling pathwayGO:07009810.1CCR5, CCL2, CCL5
4innate immune response in mucosaGO:00222710.1NOS2, IL4
5positive regulation of killing of cells of other organismGO:05171210.1IFNG, NOS2
6positive regulation of activated T cell proliferationGO:0421049.9IL2RA, IL2, IL4
7positive regulation of hair follicle developmentGO:0517989.9TNF, HPSE
8positive regulation of vitamin D biosynthetic processGO:0605579.9IFNG, TNF
9positive regulation of T cell proliferationGO:0421029.8IFNG, CCL5, IL4
10positive regulation of calcidiol 1-monooxygenase activityGO:0605599.8TNF, IFNG
11signalingGO:0230529.8CCL3, CCR5
12positive regulation of isotype switching to IgG isotypesGO:0483049.8IL2, IFNG, IL4
13extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.7IL1A, IL2, IL4
14positive regulation of MHC class II biosynthetic processGO:0453489.7IFNG, IL4
15cellular response to lipopolysaccharideGO:0712229.7CCL2, IFNG, NOS2, CCR5
16positive regulation of osteoclast differentiationGO:0456729.7IFNG, TNFSF11, TNF
17positive regulation of chemokine biosynthetic processGO:0450809.6IFNG, IL4, TNF
18T cell chemotaxisGO:0108189.6CXCR3, CCL3
19release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:0148089.6CCR5, CCL3
20macrophage chemotaxisGO:0482469.6CCL2, CCL5, CCL3
21cellular response to interleukin-1GO:0713479.5CCL2, CCL5, CCL3
22humoral immune responseGO:0069599.5CCL2, IFNG, TNF
23cell surface receptor signaling pathwayGO:0071669.5CXCR3, IL2RA, IFNG, CCR5, CCL2
24astrocyte cell migrationGO:0436159.5CCL3, CCL2
25cellular response to tumor necrosis factorGO:0713569.4CCL5, CCL2, CCL3
26monocyte chemotaxisGO:0025489.4TNFSF11, CCL3, CCL2, CCL5
27lymphocyte chemotaxisGO:0482479.4CCL2, CCL3
28cytokine-mediated signaling pathwayGO:0192219.4TNFSF11, IFNG, CCL2, IL1A
29cellular response to interferon-gammaGO:0713469.4CCL3, NOS2, CCL2, CCL5
30neutrophil chemotaxisGO:0305939.3IFNG, CCL2, CCL3
31positive regulation of natural killer cell chemotaxisGO:20005039.3CCL3, CCL5, CCL4
32negative regulation by host of viral transcriptionGO:0439229.2CCL4, CCL3, CCL5
33positive regulation of calcium ion transportGO:0519289.2CCL4, CCL5, CCL3
34calcium-mediated signalingGO:0197229.1CCR5, CXCR3, TNF, CCL3
35response to cholesterolGO:0707239.1CCR5, CCL3
36lipopolysaccharide-mediated signaling pathwayGO:0316639.1TNF, CCL5, CCL2, CCL3
37protein kinase B signalingGO:0434919.1CCL2, CCL3, TNF, CCL5
38cellular response to organic cyclic compoundGO:0714079.1TNF, CCL3, CCL2, CCL5
39response to virusGO:0096159.0CCL5, TNF, CCL4, IFNG
40cell activationGO:0017759.0CCL3, TNF
41positive regulation of protein kinase B signalingGO:0518979.0CCL3, TNFSF11, TNF, HPSE
42chemotaxisGO:0069358.9IL4, CXCR3, CCL2, CCL5, CCL3, CCR5
43response to toxic substanceGO:0096368.9CCL5, CCL4, CCL3
44MAPK cascadeGO:0001658.9CCL2, CCL5, CCL3, TNF, CCR5
45apoptotic processGO:0069158.7IFNG, IL1A, IL2RA, TNF, TNFRSF11B, CXCR3
46cell-cell signalingGO:0072678.6CCL3, CCR5, CCL5, IL2, CCL4
47immune responseGO:0069558.5IL1A, IL2RA, IL2, IL4, CCL4, CCR5
48response to drugGO:0424938.5IL4, IFNG, CCL2, TNFRSF11B, TNF, MDK
49positive regulation of transcription from RNA polymerase II promoterGO:0459448.4TNF, TNFSF11, CXCR3, IFNG, IL4, IL2
50inflammatory responseGO:0069547.4CCL3, CCL5, TNF, CCL2, CCR5, IL1A

Molecular functions related to Periapical Granuloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00495010.1CCR5, CXCR3
2phospholipase activator activityGO:0160049.1CCL5, CCL3
3CCR5 chemokine receptor bindingGO:0317308.9CCL3, CCL5, CCL4
4CCR1 chemokine receptor bindingGO:0317268.8CCL3, CCL5, CCL4
5chemokine activityGO:0080098.5CCL3, CCL5, CCL2, CCL4
6cytokine activityGO:0051257.4IL1A, TNF, TNFSF11, TNFRSF11B, CCL4, IFNG

Products for genes affiliated with Periapical Granuloma

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Periapical Granuloma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet