MCID: PRP002
MIFTS: 50

Periapical Granuloma malady

Summaries for Periapical Granuloma

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MalaCards: Periapical Granuloma, also known as apical granuloma, is related to leprosy and lepromatous leprosy. An important gene associated with Periapical Granuloma is MMP13 (matrix metallopeptidase 13 (collagenase 3)), and among its related pathways are Rheumatoid arthritis and Leishmaniasis. The compounds endotoxin and pge2 have been mentioned in the context of this disorder. Affiliated tissues include endothelial, bone and colon, and related mouse phenotypes are reproductive system and integument.

Aliases & Classifications for Periapical Granuloma

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8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

periapical granuloma 8 44 60
apical granuloma 8


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Disease Ontology8 DOID:4617
SNOMED-CT56 81407003, 196344002
MeSH34 D010484

Related Diseases for Periapical Granuloma

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17GeneCards, 18GeneDecks
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Diseases related to Periapical Granuloma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 232)
idRelated DiseaseScoreTop Affiliating Genes
1leprosy30.1IL2
2lepromatous leprosy30.1IL2, IL4, IFNG
3lichen planus10.0CXCR3
4meningitis10.0CCL4
5osteomyelitis10.0TNFSF11
6polymyalgia rheumatica10.0CCL5
7measles10.0CCL4
8down syndrome10.0CCL4
9kawasaki disease10.0CCL2
10chagas disease10.0CCR5
11chondrosarcoma10.0MMP13
12wegener's granulomatosis10.0CCR5
13giant cell tumor10.0TNFSF11
14eye disease10.0CCL2
15gastrointestinal system disease10.0NOS2
16cerebral palsy10.0MMP8
17hypertension10.0CCL2
18hyperglycemia10.0NOS2
19bronchopulmonary dysplasia10.0CCL3
20hemophagocytic lymphohistiocytosis10.0IL2RA
21pleurisy10.0IL2RA
22arteriosclerosis10.0CCL2
23bronchiectasis10.0MMP8
24myocarditis10.0NOS2
25hypercholesterolemia10.0NOS2
26guillain-barre syndrome10.0CCR5
27farmer's lung10.0IL2RA
28cystic fibrosis10.0TNFRSF11B
29proliferative diabetic retinopathy10.0CCL2
30nephritis10.0CXCR3, CCL2
31human immunodeficiency virus infectious disease10.0CCL3, CCL4
32pulmonary alveolar proteinosis10.0CCL2
33omenn syndrome10.0IL4
34neuritis10.0CCL4, CCL5
35bronchiolitis10.0CCL3, CCL5
36tonsillitis10.0IL1A
37laryngeal squamous cell carcinoma10.0MMP13
38cervical cancer10.0IL1A
39sarcoma10.0IL2
40coronary heart disease10.0MMP8, CCR5
41pemphigus vulgaris10.0IL1A
42proliferative glomerulonephritis10.0CXCR3, CCL2
43bronchiolitis obliterans10.0MMP8, CXCR3
44malignant glioma10.0IL2
45bacterial vaginosis10.0IL1A
46vaccinia10.0IL2
47essential hypertension10.0CCR5
48lyme disease10.0CCL3, CCL4
49rhinitis10.0IL4, CCL5
50anaplastic large cell lymphoma10.0IL2RA, CXCR3

Graphical network of the top 20 diseases related to Periapical Granuloma:



Diseases related to periapical granuloma

Clinical Features for Periapical Granuloma

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Drugs & Therapeutics for Periapical Granuloma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Genetic Tests for Periapical Granuloma

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Anatomical Context for Periapical Granuloma

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MalaCards organs/tissues related to Periapical Granuloma:

32
Endothelial, Bone, Colon, Monocytes, T cells

Animal Models for Periapical Granuloma or affiliated genes

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36MGI
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Publications for Periapical Granuloma

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50PubMed
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Articles related to Periapical Granuloma:

(show all 33)
idTitleAuthorsYear
1
Heparanase expression in periapical granulomas and radicular cysts. (22020734)
2013
2
Periapical granuloma associated with extracted teeth. (22037071)
2011
3
Midkine expression in human periapical granulomas. (21787488)
2011
4
Distinct Th1, Th2 and Treg cytokines balance in chronic periapical granulomas and radicular cysts. (20102461)
2010
5
T-helper cell type 17/regulatory T-cell immunoregulatory balance in human radicular cysts and periapical granulomas. (20478453)
2010
6
High matrix metalloproteinase activity is a hallmark of periapical granulomas. (19720222)
2009
7
Antrochoanal polyp derived from periapical granuloma. (18701055)
2008
8
Differential patterns of receptor activator of nuclear factor kappa B ligand/osteoprotegerin expression in human periapical granulomas: possible association with progressive or stable nature of the lesions. (18634923)
2008
9
Involvement of inducible nitric oxide synthase and receptor for advanced glycation end products in periapical granulomas. (17258631)
2007
10
RANKL in human periapical granuloma: possible involvement in periapical bone destruction. (16700737)
2006
11
Receptor activator NFkappaB-ligand and osteoprotegerin protein expression in human periapical cysts and granulomas. (16920551)
2006
12
Co-production of vascular endothelial cadherin and inducible nitric oxide synthase by endothelial cells in periapical granuloma. (16507070)
2006
13
Oral diagnosis. Interradicular radiolucency of maxilla. Periapical granuloma. (16161239)
2005
14
Intraneural epithelial islands associated with a periapical granuloma: a cause for concern? (12796887)
2003
15
Hydrogen peroxide and superoxide anion production by polymorphonuclear neutrophils in patients with chronic periapical granuloma, before and after surgical treatment. (11355101)
2001
16
Evaluation of immunoglobulin G synthesizing plasma cells in periapical granuloma and cyst. (11441800)
2001
17
The presence of chemokine receptor (CCR5, CXCR3, CCR3)-positive cells and chemokine (MCP1, MIP-1alpha, MIP-1beta, IP-10)-positive cells in human periapical granulomas. (11683586)
2001
18
Differential in situ distribution of interleukin-8, monocyte chemoattractant protein-1 and Rantes in human chronic periapical granuloma. (11155167)
2000
19
Cytotoxic T lymphocytes versus streptococcal colonization in periapical granulomas. (10425947)
1999
20
Focal cemento-osseous dysplasia in the maxilla mimicking periapical granuloma. (10442950)
1999
21
Interferon-gamma-producing cells and inducible nitric oxide synthase-producing cells in periapical granulomas. (9563799)
1998
22
Immune cells in periapical granuloma: morphological and immunohistochemical characterization. (1895036)
1991
23
Quantitative analysis of the immunocompetent cells in periapical granuloma: correlation with the histological characteristics of the lesions. (1974913)
1990
24
The role of acute phase proteins in the pathogenesis of chronic periapical granuloma]. (1698164)
1990
25
Acute phase proteins in patients with chronic periapical granuloma before and after surgical treatment. (3268759)
1988
26
Endodontic treatment and immunopathology of periapical granuloma in an AIDS patient. (2977755)
1988
27
In situ characterization of cells in periapical granuloma by monoclonal antibodies. (3477750)
1987
28
Bacteriological status of periapical granuloma. (6597195)
1984
29
Macrophages isolated from periapical granuloma: a scanning electron microscopic study. (6592531)
1984
30
Isolation and characterization of inflammatory cells from the human periapical granuloma. (6983538)
1982
31
Quantitative analysis of cellular composition of human periapical granuloma. (6938631)
1981
32
Reddening of the upper central incisors associated with periapical granuloma in lepromatous leprosy. (1063039)
1976
33
A colony of actinomyces-like organisms in a periapical granuloma. (4161341)
1966

Genetic Variations for Periapical Granuloma

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Expression for genes affiliated with Periapical Granuloma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Periapical Granuloma

Search GEO for disease gene expression data for Periapical Granuloma.

Pathways for genes affiliated with Periapical Granuloma

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29KEGG, 51QIAGEN, 37NCBI BioSystems Database, 59Tocris Bioscience, 52R&D Systems, 12EMD Millipore, 4Cell Signaling Technology, 53Reactome
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Pathways related to Periapical Granuloma according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3TNFSF11
2
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9.9CCR5, IL1A
3
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9.8IL2, IL2RA
4
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9.6TNF, MMP13, MMP8
5
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9.6IL2, IL4, IL2RA
6
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9.5IL2, IL1A, IL2RA
7
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9.4IL2, IL2RA, IFNG
89.4IL2, IL2RA, IFNG
99.4NOS2, IL1A, TNF
109.4NOS2, IL1A, TNF
119.4IFNG, IL4, IL2
129.4CCL2, IFNG, TNF
13
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9.2IFNG, TNF, IL2
14
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.2IL1A, TNFRSF11B, TNFSF11, IFNG
15
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9.2TNF, MDK, IL1A
16
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9.2IL1A, TNF, TNFRSF11B, TNFSF11
179.1IFNG, IL2RA, IL4, IL2
189.1IFNG, IL2RA, IL4, IL2
199.1CCL5, TNFSF11, IL2RA, IL4, IL2
209.1IL1A, IL4, IL2RA, TNF
21
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9.1IL2, IL4, IL2RA, TNF
22
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9.0NOS2, IL1A, TNF, IFNG
23
Immune response Bacterial infections in normal airways
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9.0IFNG, TNF, IL1A, NOS2
249.0NOS2, IL2, TNF, IFNG
259.0IL2, IL2RA, TNF, IFNG
269.0CCL2, CCL3, TNF
27
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8.8CCL5, CCR5, CCL2, TNFSF11, TNFRSF11B, TNF
28
Development PDGF signaling via STATs and NF-kB
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8.8CCL2, IFNG, TNF, IL2, NOS2
298.7IFNG, TNFSF11, TNFRSF11B, TNF, IL1A
30
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8.7IL1A, IL4, IL2RA, TNF, IFNG
31
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8.7IFNG, TNF, IL2RA, IL4, IL2
328.6IFNG, TNF, IL4, IL1A, IL2
33
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8.6CCL5, CCL4, CCR5, CCL3
348.5CCL2, TNF, IL4, IL1A, IL2, NOS2
35
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8.4CCR5, IFNG, TNF, IL4, IL1A, IL2
36
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8.3IFNG, TNF, IL2RA, IL4, IL1A, IL2
37
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8.2CCL5, CCL4, CCL2, MDK, IL2RA, IL2
38
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8.2CCR5, CCL3, TNFSF11, MDK, CDH5, CXCR3
398.1CCL5, CCL4, CCR5, CCL2, CCL3, CXCR3
40
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8.1CCL5, CCL4, CCR5, CCL2, CCL3, CXCR3
41
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8.1CCL5, CCL4, CCR5, CCL2, CCL3, CXCR3
42
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8.1IL1A, IL2RA, CXCR3, TNFRSF11B, TNFSF11, CCL3
438.0CCL4, CCL3, IFNG, IL1A, NOS2
44
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7.9CCL5, CCL2, IFNG, TNF, IL2RA, IL4
45
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7.5CCL4, CCL3, IFNG, TNF, IL2RA, IL2
46
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7.5CCL4, CCR5, CCL3, IFNG, IL2RA, IL4
47
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7.4CCL5, CCL4, CCR5, CCL2, CCL3, CDH5
48
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7.4CCL5, CCL4, IL2RA, CXCR3, MDK, TNFSF11
49
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7.1CCL5, CCL4, CCL2, CCL3, IFNG, TNF
50
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5.7IL1A, IL4, IL2RA, CXCR3, MDK, TNF

Compounds for genes affiliated with Periapical Granuloma

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44Novoseek, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR, 24HMDB
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Compounds related to Periapical Granuloma according to GeneCards/GeneDecks:

(show top 50)    (show all 205)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.7CXCR3
2pge24410.5IL2
3pentoxifylline44 1111.3IL4
4hydrocortisone44 2 59 1113.3TNFRSF11B, CDH5
5dexamethasone44 49 28 1112.9CCL5, TNFSF11, TNFRSF11B, MMP13
6gm-csf44 2810.8CCL5, IFNG, TNF
7pdtc449.8CCL5, CCL2, IL1A, NOS2
8prednisolone44 28 1111.4CCL4, TNFRSF11B, IL2RA, MMP13
9ivig449.2CCL4, CCR5, IFNG, IL1A
10gold sodium thiomalate448.8IFNG, TNF, IL2RA, IL1A, IL2
11creatinine448.8TNFSF11, TNFRSF11B, CXCR3, IL1A, CCL4
12il-12448.7CCL2, IFNG, TNF, IL4, IL2
13infliximab44 49 1110.7IFNG, TNFSF11, TNFRSF11B, TNF, CXCR3, IL2RA
14mcp 1448.6CCL5, CCL4, CCL2, CCL3, CXCR3
15polymyxin b448.6CCL2, IFNG, TNFSF11, TNFRSF11B, TNF, IL4
16mdms448.5CCL5, CCL4, CCR5, CCL2, CCL3
17cyclosporin a44 28 5910.4MMP8, IL2RA, CCL5, CCL3, IFNG, TNFSF11
18thalidomide44 49 59 1111.4CCL5, IFNG, TNFRSF11B, TNF, IL2RA, IL1A
19ribavirin44 49 1110.3CCR5, CCL3, IFNG, CXCR3, IL4, IL2
20larc448.2CCL5, CCL4, CCR5, CCL2, CCL3, CXCR3
21toxin-1448.2CCL4, CCL2, CCL3, TNF, IL2
22ccl444 289.2CCL5, CCL4, CCR5, CCL2, CCL3, TNFSF11
23calcitriol44 59 11 2410.9CCL5, IFNG, TNFSF11, TNFRSF11B, TNF, IL2RA
24polyinosinic-polycytidylic acid447.9CCL3, IFNG, TNF, IL4, IL1A, IL2
25mip 1alpha447.8TNF, IL4, TNFSF11, CCL3, CCL5, CCL4
26neopterin447.8CCL3, IFNG, TNF, IL2RA, IL4, IL1A
27ly294002447.8CCL5, CCL2, CCL3, TNFSF11, TNFRSF11B, TNF
28herbimycin a44 598.6CCL2, IFNG, TNF, HPSE, IL2RA, IL4
29groalpha447.6CCL3, TNF, CXCR3, IL1A, MMP13, CCL2
30triptolide447.5CCL5, CCL4, CCL2, CCL3, IFNG, TNF
31heparin44 28 11 2410.4CCL5, CCL4, CCR5, CCL3, TNFSF11, TNFRSF11B
32oxygen44 248.4CCL2, CCL3, TNFSF11, TNF, CDH5, HPSE
33ccl344 288.4TNF, CXCR3, IL1A, CCL5, CCL4, CCR5
34heparan sulfate44 248.3CCL5, CCL4, CCL3, TNFSF11, TNFRSF11B, MDK
35simvastatin44 49 59 28 11 2412.2CCL5, CCL4, CCR5, CCL2, CCL3, IFNG
36actinomycin d447.2CCR5, CCL2, CCL3, IFNG, TNF, IL4
37genistein44 28 59 2 11 2412.1MMP8, NOS2, CCL2, IFNG, TNFSF11, TNFRSF11B
38rantes447.1CCL4, CCL3, IFNG, TNF, CXCR3, IL2RA
39tarc447.1IL1A, IL4, CCL5, CCL4, CCR5, CCL2
40tacrolimus44 49 119.1CCL5, CCL4, CCL3, IFNG, TNFSF11, TNF
41thymidine44 248.0CCL3, IFNG, TNF, CXCR3, IL2RA, IL4
42ionomycin447.0CCL5, CCL4, CCL3, IFNG, TNF, IL2RA
43serine446.7CCL5, CCL4, CCR5, CCL2, CCL3, TNFSF11
44sb 20358044 597.6CCL5, CCL4, CCL2, CCL3, IFNG, TNFSF11
45histamine44 28 248.5CCL2, CCL3, IFNG, TNF, CDH5, CXCR3
46il 10446.4CCL3, IFNG, TNF, CXCR3, IL2RA, IL4
47cysteine446.4CCL5, CCL4, CCR5, CCL3, IFNG, TNFSF11
48retinoic acid44 247.2CCL5, CCL4, CCR5, CCL3, IFNG, TNFRSF11B
49nitric oxide44 11 247.6IL1A, MMP13, MMP8, NOS2, CXCR3, HPSE
50vegf444.7TNF, CDH5, HPSE, CXCR3, IL2RA, IL4

GO Terms for genes affiliated with Periapical Granuloma

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16Gene Ontology
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Cellular components related to Periapical Granuloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.6IL4, IL2RA, CXCR3, TNF, IFNG, CCR5
2extracellular spaceGO:0056155.7MMP8, CCL5, CCL4, CCL2, CCL3, IFNG
3extracellular regionGO:0055764.7TNFSF11, IFNG, CCL3, CCL2, CCL4, CCL5

Biological processes related to Periapical Granuloma according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of homotypic cell-cell adhesionGO:03411210.4CCL5, TNFSF11
2innate immune response in mucosaGO:00222710.2NOS2, IL4
3regulation of T cell homeostatic proliferationGO:04601310.2IL2RA, IL2
4chemokine-mediated signaling pathwayGO:07009810.2CCL2, CCR5, CCL5
5positive regulation of killing of cells of other organismGO:05171210.1NOS2, IFNG
6positive regulation of macrophage chemotaxisGO:01075910.0CCL5, CCL2
7positive regulation of vitamin D biosynthetic processGO:06055710.0IFNG, TNF
8positive regulation of activated T cell proliferationGO:0421049.9IL2, IL4, IL2RA
9positive regulation of calcidiol 1-monooxygenase activityGO:0605599.9TNF, IFNG
10positive regulation of MHC class II biosynthetic processGO:0453489.9IFNG, IL4
11positive regulation of isotype switching to IgG isotypesGO:0483049.8IFNG, IL4, IL2
12positive regulation of T cell proliferationGO:0421029.8CCL5, IFNG, IL4
13positive regulation of osteoclast differentiationGO:0456729.8IFNG, TNFSF11, TNF
14signalingGO:0230529.8CCR5, CCL3
15positive regulation of chemokine biosynthetic processGO:0450809.7IFNG, TNF, IL4
16T cell chemotaxisGO:0108189.7CXCR3, CCL3
17cellular response to lipopolysaccharideGO:0712229.7CCR5, CCL2, IFNG, NOS2
18positive regulation of hair follicle developmentGO:0517989.7TNF, HPSE
19humoral immune responseGO:0069599.7CCL2, IFNG, TNF
20astrocyte cell migrationGO:0436159.6CCL2, CCL3
21macrophage chemotaxisGO:0482469.6CCL5, CCL2, CCL3
22release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:0148089.6CCL3, CCR5
23response to cholesterolGO:0707239.6CCR5, CCL3
24cellular response to interleukin-1GO:0713479.5CCL5, CCL2, CCL3
25cell surface receptor signaling pathwayGO:0071669.5CCR5, CCL2, IFNG, CXCR3, IL2RA
26lymphocyte chemotaxisGO:0482479.5CCL2, CCL3
27monocyte chemotaxisGO:0025489.4TNFSF11, CCL3, CCL2, CCL5
28cellular response to tumor necrosis factorGO:0713569.4CCL3, CCL2, CCL5
29cellular response to interferon-gammaGO:0713469.4NOS2, CCL3, CCL2, CCL5
30neutrophil chemotaxisGO:0305939.3CCL2, CCL3, IFNG
31response to glucocorticoid stimulusGO:0513849.3MDK, TNF, CCL2
32positive regulation of natural killer cell chemotaxisGO:20005039.2CCL3, CCL4, CCL5
33negative regulation by host of viral transcriptionGO:0439229.2CCL3, CCL4, CCL5
34positive regulation of calcium ion transportGO:0519289.2CCL3, CCL4, CCL5
35calcium-mediated signalingGO:0197229.2CXCR3, TNF, CCL3, CCR5
36lipopolysaccharide-mediated signaling pathwayGO:0316639.2TNF, CCL3, CCL2, CCL5
37cellular response to organic cyclic compoundGO:0714079.2CCL5, CCL2, CCL3, TNF
38protein kinase B signaling cascadeGO:0434919.2CCL5, CCL2, CCL3, TNF
39response to virusGO:0096159.1TNF, IFNG, CCL4, CCL5
40cell activationGO:0017759.1CCL3, TNF
41cytokine-mediated signaling pathwayGO:0192219.0CCL2, IFNG, TNFSF11, IL1A
42MAPK cascadeGO:0001659.0CCL5, CCR5, CCL2, CCL3, TNF
43positive regulation of protein kinase B signaling cascadeGO:0518978.9HPSE, TNF, TNFSF11, CCL3
44apoptotic processGO:0069158.8IFNG, TNFRSF11B, TNF, CXCR3, IL2RA, IL1A
45response to drugGO:0424938.7CCL2, IFNG, TNFRSF11B, TNF, MDK, IL4
46positive regulation of transcription from RNA polymerase II promoterGO:0459448.7IFNG, TNFSF11, TNF, IL4, IL1A, IL2
47immune responseGO:0069558.6CCL4, CCR5, TNFSF11, IL2RA, IL4, IL1A
48cell-cell signalingGO:0072678.6CCL5, CCL4, CCR5, CCL3, IL2
49chemotaxisGO:0069358.3CCL5, CCL4, CCR5, CCL2, CCL3, CXCR3
50inflammatory responseGO:0069547.5NOS2, CCL5, CCL4, CCR5, CCL2, CCL3

Molecular functions related to Periapical Granuloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipase activator activityGO:0160049.4CCL3, CCL5
2CCR5 chemokine receptor bindingGO:0317308.8CCL5, CCL4, CCL3
3CCR1 chemokine receptor bindingGO:0317268.7CCL3, CCL4, CCL5
4chemokine activityGO:0080098.3CCL5, CCL4, CCL2, CCL3
5cytokine activityGO:0051257.5IL2, IL1A, IL4, TNF, TNFRSF11B, TNFSF11

Products for genes affiliated with Periapical Granuloma

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3CDC
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25ICD10
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27ICD9CM
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