MCID: PRP002
MIFTS: 25

Periapical Granuloma malady

Category: Oral diseases

Aliases & Classifications for Periapical Granuloma

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Aliases & Descriptions for Periapical Granuloma:

Name: Periapical Granuloma 10 47 12 36 65
 
Apical Granuloma 10

Classifications:



External Ids:

Disease Ontology10 DOID:4617
SNOMED-CT59 196344002, 81407003
MeSH36 D010484
UMLS65 C0031029

Summaries for Periapical Granuloma

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MalaCards based summary: Periapical Granuloma, also known as apical granuloma, is related to polycystic kidney disease and arthropathy. An important gene associated with Periapical Granuloma is TNFSF11 (Tumor Necrosis Factor Superfamily Member 11), and among its related pathways are Development_Hedgehog and PTH signaling pathways in bone and cartilage development and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. Affiliated tissues include neutrophil, t cells and breast, and related mouse phenotypes are homeostasis/metabolism and immune system.

Related Diseases for Periapical Granuloma

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Graphical network of the top 20 diseases related to Periapical Granuloma:



Diseases related to periapical granuloma

Symptoms for Periapical Granuloma

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Drugs & Therapeutics for Periapical Granuloma

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Interventional clinical trials:

idNameStatusNCT IDPhase
1RCT: Effectiveness of a Microscope During Dental Root Apical SurgeryRecruitingNCT01759069

Search NIH Clinical Center for Periapical Granuloma


Cochrane evidence based reviews: periapical granuloma

Genetic Tests for Periapical Granuloma

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Anatomical Context for Periapical Granuloma

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MalaCards organs/tissues related to Periapical Granuloma:

33
Neutrophil, T cells, Breast

Animal Models for Periapical Granuloma or affiliated genes

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MGI Mouse Phenotypes related to Periapical Granuloma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.9CDH5, IL2, IL4, MMP13, MMP8, TNFSF11
2MP:00053877.3CCL5, CDH5, IL2, IL4, MMP8, TNFSF11

Publications for Periapical Granuloma

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Articles related to Periapical Granuloma:

(show all 35)
idTitleAuthorsYear
1
Pleuropulmonary nocardiosis due to Nocardia otitidiscaviarum in a debilitated host. (27166054)
2016
2
Common Variants in LRP2 and COMT Genes Affect the Susceptibility of Gout in a Chinese Population. (26147675)
2015
3
Successful treatment of facial papules with electrodessication in a patient with Birt-Hogg-DubAc syndrome. (25046466)
2014
4
Effects of ezetimibe on atherogenic lipoproteins and glucose metabolism in patients with diabetes and glucose intolerance. (23369229)
2013
5
BRCA1/2 mutation screening in high-risk breast/ovarian cancer families and sporadic cancer patient surveilling for hidden high-risk families. (23767878)
2013
6
CD47 fusion protein targets CD172a+ cells in Crohn's disease and dampens the production of IL-1I^ and TNF. (23669395)
2013
7
Impact of cadmium exposure during pregnancy on hepatic glucocorticoid receptor methylation and expression in rat fetus. (22957049)
2012
8
Incidence and clinical characteristics of clonal cytogenetic abnormalities of acquired aplastic anemia in adults. (21253425)
2010
9
Incidence of intestinal obstruction following intraperitoneal chemotherapy for ovarian tubal and peritoneal malignancies. (19254808)
2009
10
Dexamethasone suppresses interleukin-22 associated with bacterial infection in vitro and in vivo. (19664145)
2009
11
Obesity and insulin resistance]. (19202894)
2009
12
The potential health and economic benefits of preventing recurrent respiratory papillomatosis through quadrivalent human papillomavirus vaccination. (18598734)
2008
13
Homeostasis and effector function of lymphopenia-induced "memory-like" T cells in constitutively T cell-depleted mice. (18354198)
2008
14
Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation. (17259996)
2007
15
Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes. (17313370)
2007
16
Virchow's node, jaundice, and weight loss--lymphoma mimicking gastrointestinal malignancy. (17068502)
2006
17
Bilateral adrenal cysts and ectopic pancreatic tissue in Beckwith-Wiedemann syndrome: is a conservative approach acceptable? (15270410)
2004
18
Redox ratio of mitochondria as an indicator for the response of photodynamic therapy. (15250765)
2004
19
Phenotypic and molecular analyses of X-linked dystonia-parkinsonism ("lubag") in women. (15596620)
2004
20
The role of hsp90 in heme-dependent activation of apo-neuronal nitric-oxide synthase. (15155759)
2004
21
A mystery of AHNAK/desmoyokin still goes on. (15373799)
2004
22
ApoE genotype, past adult lead exposure, and neurobehavioral function. (12003753)
2002
23
Matrix metalloproteinase-2, membranous type 1 matrix metalloproteinase, and tissue inhibitor of metalloproteinase-2 expression in ectopic and eutopic endometrium. (12372458)
2002
24
Circumcision in a combined factor V and factor VIII deficiency using desmopressin (DDAVP). (12026204)
2002
25
Human immune responses to Schistosoma mansoni vaccine candidate antigens. (10768975)
2000
26
Effects of geldanamycin and other naturally occurring small molecule antagonists of heat shock protein 90 on HER2 protein expression. (15687592)
2000
27
The relationship between the prognosis of retinoblastoma and proliferating cell nuclear antigen and argyrophilic protein at nucleolus organizer regions]. (10451965)
1997
28
Mechanisms of retinoid resistance in leukemic cells: possible role of cytochrome P450 and P-glycoprotein. (8555497)
1996
29
Diagnosis of low level coccidiosis (Eimeria) infection in laboratory rabbits: evaluation of detection methods. (16457504)
1996
30
Isolation and characterization of a cDNA encoding the alpha' subunit of human cone cGMP-phosphodiesterase. (8543163)
1995
31
Localization of transforming growth factor-alpha in human appendageal tumors. (1519669)
1992
32
Chloride-37 nuclear magnetic resonance spectroscopic study of binding of salicylic acid and other hydroxybenzoic acids to the band 3 anion transport protein of human erythrocytes. (1403671)
1992
33
Sequences of complementary DNAs that encode the NA1 and NA2 forms of Fc receptor III on human neutrophils. (2478590)
1989
34
Hypertension and aldosterone overproduction without renin suppression in Cushing's syndrome from an adrenal adenoma. (474601)
1979
35
Essential fructosuria in two siblings. (18903387)
1948

Variations for Periapical Granuloma

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Expression for genes affiliated with Periapical Granuloma

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Search GEO for disease gene expression data for Periapical Granuloma.

Pathways for genes affiliated with Periapical Granuloma

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GO Terms for genes affiliated with Periapical Granuloma

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Biological processes related to Periapical Granuloma according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of T cell differentiationGO:00455829.9IL2, IL4
2extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.9IL2, IL4
3positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.9IL2, IL4
4positive regulation of B cell proliferationGO:00308909.9IL2, IL4
5positive regulation of homotypic cell-cell adhesionGO:00341129.8CCL5, TNFSF11
6positive regulation of isotype switching to IgG isotypesGO:00483049.7IL2, IL4
7positive regulation of phosphorylationGO:00423279.7CCL5, TNFSF11
8positive regulation of osteoclast differentiationGO:00456729.7CCL5, TNFSF11
9positive regulation of protein phosphorylationGO:00019349.5IL2, IL4
10monocyte chemotaxisGO:00025489.5CCL5, TNFSF11
11positive regulation of inflammatory responseGO:00507299.4CCL5, IL2
12positive regulation of T cell proliferationGO:00421029.0CCL5, IL2, IL4
13chemotaxisGO:00069358.7CCL5, IL4
14response to drugGO:00424938.6CCL5, IL4, MMP13
15immune responseGO:00069558.1CCL5, IL2, IL4, TNFSF11

Molecular functions related to Periapical Granuloma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00042229.5MMP13, MMP8

Sources for Periapical Granuloma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet