Aliases & Classifications for Periapical Granuloma

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Sources:
8Disease Ontology, 44Novoseek, 61UMLS, 33MeSH, 56SNOMED-CT
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Aliases & Descriptions for Periapical Granuloma:

Name: Periapical Granuloma 8 44 61
 
Apical Granuloma 8


External Ids:

Disease Ontology8 DOID:4617
SNOMED-CT56 81407003, 196344002
MeSH33 D010484

Summaries for Periapical Granuloma

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MalaCards based summary: Periapical Granuloma, also known as apical granuloma, is related to leprosy and lepromatous leprosy. An important gene associated with Periapical Granuloma is MMP8 (matrix metallopeptidase 8 (neutrophil collagenase)), and among its related pathways are Matrix Metalloproteinases and IL2 signaling events mediated by PI3K. The compounds mcp 1 and gold sodium thiomalate have been mentioned in the context of this disorder. Affiliated tissues include endothelial, bone and colon, and related mouse phenotypes are no phenotypic analysis and vision/eye.

Related Diseases for Periapical Granuloma

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Diseases related to Periapical Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1leprosy30.9IL2
2lepromatous leprosy30.1IL2, IL4, IFNG
3farmer's lung10.6IL2RA
4bronchiolitis10.5CCL5, CCL3
5meningococcemia10.5CCL5
6chronic ulcer of skin10.4MMP8, MMP13
7proliferative glomerulonephritis10.4CCL2, CXCR3
8bacterial meningitis10.4CCL4, CCL3, MMP8
9intermediate uveitis10.4IL2RA, CCR5, CXCR3
10dengue disease10.4CCL4, CCL5, CCL3
11bronchiolitis obliterans10.4CXCR3, MMP8
12pulpitis10.4IL1A
13periodontal disease10.4TNFSF11, TNF
14systemic mastocytosis10.4CCL2, CCL5, CCL3
15vernal keratoconjunctivitis10.3IL4, CCL5, CXCR3
16osteolysis, familial expansile10.3TNFRSF11B, TNFSF11
17paget disease, juvenile10.3TNFRSF11B, TNFSF11
18central nervous system disease10.3CCR5, CCL2, CXCR3
19peripheral t-cell lymphoma10.3NOS2, IL2RA, CXCR3
20sjogren's syndrome10.3IL2RA, CCL3, CXCR3
21aggressive periodontitis10.3IL1A, MMP8
22pulmonary eosinophilia10.3IL4, CCL3
23contact dermatitis10.3IL1A, CXCR3
24pleurisy10.3IL2RA
25gastritis10.3NOS2, CCL5, CCL3
26hyperostosis, endosteal10.3TNFRSF11B, TNFSF11
27factor v leiden thrombophilia10.3CCL5, MMP8, MMP13, TNFSF11
28bone cancer10.3MMP13, TNFRSF11B, TNFSF11
29aortic valve disease 210.3CCR5, TNFRSF11B, TNFSF11
30extrinsic allergic alveolitis10.3IL1A, CCL3
31stroke, ischemic10.3CCL4, CCL3, MMP8, MMP13
32acute myocardial infarction10.2CDH5, CCL5, MMP8, TNFSF11
33idiopathic myopathy10.2IL1A, CCL2, CCL5
34middle ear cholesteatoma10.2IL1A, TNFSF11
35peritonitis10.2CCL2, MMP8, TNF
36marchiafava bignami disease10.2TNFRSF11B, TNFSF11
37glomerulonephritis10.2NOS2, CCL4, CCR5, CCL2
38aspergillosis10.2IFNG, CCL3
39aids dementia complex10.2NOS2, CCR5, TNF
40multiple myeloma10.2CCL3, TNFRSF11B, TNFSF11
41pulmonary fibrosis10.2CCL4, CCL2, CCL3, CXCR3, MMP13
42burkitt lymphoma10.2IL4, CCL3, CXCR3
43polymyositis10.2IL1A, CCR5, CCL3
44agammaglobulinemia10.2IL2, IL4
45osteoporosis10.2MMP8, MMP13, TNFRSF11B, TNFSF11
46periodontitis10.2IL1A, MMP8, TNFRSF11B
47secondary syphilis10.2CCL4, CCL3, TNFRSF11B, TNFSF11
48oral lichen planus10.2IL1A, CCR5, CCL5, CXCR3
49mycosis fungoides10.2IL2RA, IL2, CXCR3
50tuberculoid leprosy10.2IL2RA, IFNG

Graphical network of the top 20 diseases related to Periapical Granuloma:



Diseases related to periapical granuloma

Symptoms for Periapical Granuloma

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Drugs & Therapeutics for Periapical Granuloma

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Drug clinical trials:

Search ClinicalTrials for Periapical Granuloma

Search NIH Clinical Center for Periapical Granuloma

Genetic Tests for Periapical Granuloma

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Anatomical Context for Periapical Granuloma

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MalaCards organs/tissues related to Periapical Granuloma:

31
Endothelial, Bone, Colon, Monocytes, T cells, Neutrophil

Animal Models for Periapical Granuloma or affiliated genes

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MGI Mouse Phenotypes related to Periapical Granuloma:

35 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.4IL4, IFNG, CCR5, TNFSF11, TNF, IL2
2MP:00053918.3CDH5, TNF, CCL2, CCR5, IFNG, IL4
3MP:00053908.1TNFRSF11B, NOS2, IFNG, CCL2, MMP13, TNF
4MP:00053828.1IL4, NOS2, TNF, TNFSF11, TNFRSF11B, CCL2
5MP:00053798.1TNF, TNFSF11, IL2, IFNG, HPSE, IL4
6MP:00053888.0TNF, CXCR3, IFNG, IL4, IL2, NOS2
7MP:00020067.9TNF, MMP8, CXCR3, CCL2, CCR5, IFNG
8MP:00107717.9NOS2, TNFSF11, MMP13, CCL2, IFNG, TNF
9MP:00053707.8IFNG, CCR5, CCL2, IL2, TNF, IL4
10MP:00053897.5TNF, NOS2, IL2, MDK, IL4, IFNG
11MP:00053817.3IL2, IL2RA, NOS2, IL4, IFNG, CCR5
12MP:00036317.1TNF, CCL3, MDK, NOS2, IL4, IFNG
13MP:00053866.9CCR5, IFNG, NOS2, CCL2, CCL3, TNF
14MP:00053786.4CDH5, NOS2, IFNG, IL2RA, TNFSF11, IL2
15MP:00053856.4IFNG, CDH5, TNFRSF11B, MMP13, CXCR3, TNF
16MP:00107686.2CCL3, TNFSF11, CCR5, CDH5, NOS2, IL2RA
17MP:00053766.0MDK, NOS2, IL1A, IL2, IL4, CCR5
18MP:00053846.0IL2, CCL2, CCR5, CDH5, TNF, TNFRSF11B
19MP:00053875.0CDH5, CXCR3, MMP8, TNFRSF11B, TNFSF11, TNF
20MP:00053974.8CDH5, MDK, HPSE, IL1A, IL2RA, IL2

Publications for Periapical Granuloma

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Articles related to Periapical Granuloma:

(show all 35)
idTitleAuthorsYear
1
Bioinformatics, Interaction Network Analysis, and Neural Networks to Characterize Gene Expression of Radicular Cyst and Periapical Granuloma. (25873079)
2015
2
Expression and immunohistochemical localization of leptin receptor in human periapical granuloma. (25081278)
2014
3
Heparanase expression in periapical granulomas and radicular cysts. (22020734)
2013
4
Oral pathology quiz #81. Case number 4. Dental (periapical) granuloma. (24597181)
2013
5
Periapical granuloma associated with extracted teeth. (22037071)
2011
6
Midkine expression in human periapical granulomas. (21787488)
2011
7
Distinct Th1, Th2 and Treg cytokines balance in chronic periapical granulomas and radicular cysts. (20102461)
2010
8
T-helper cell type 17/regulatory T-cell immunoregulatory balance in human radicular cysts and periapical granulomas. (20478453)
2010
9
High matrix metalloproteinase activity is a hallmark of periapical granulomas. (19720222)
2009
10
Antrochoanal polyp derived from periapical granuloma. (18701055)
2008
11
Differential patterns of receptor activator of nuclear factor kappa B ligand/osteoprotegerin expression in human periapical granulomas: possible association with progressive or stable nature of the lesions. (18634923)
2008
12
Involvement of inducible nitric oxide synthase and receptor for advanced glycation end products in periapical granulomas. (17258631)
2007
13
RANKL in human periapical granuloma: possible involvement in periapical bone destruction. (16700737)
2006
14
Co-production of vascular endothelial cadherin and inducible nitric oxide synthase by endothelial cells in periapical granuloma. (16507070)
2006
15
Oral diagnosis. Interradicular radiolucency of maxilla. Periapical granuloma. (16161239)
2005
16
Intraneural epithelial islands associated with a periapical granuloma: a cause for concern? (12796887)
2003
17
Hydrogen peroxide and superoxide anion production by polymorphonuclear neutrophils in patients with chronic periapical granuloma, before and after surgical treatment. (11355101)
2001
18
Evaluation of immunoglobulin G synthesizing plasma cells in periapical granuloma and cyst. (11441800)
2001
19
The presence of chemokine receptor (CCR5, CXCR3, CCR3)-positive cells and chemokine (MCP1, MIP-1alpha, MIP-1beta, IP-10)-positive cells in human periapical granulomas. (11683586)
2001
20
Differential in situ distribution of interleukin-8, monocyte chemoattractant protein-1 and Rantes in human chronic periapical granuloma. (11155167)
2000
21
Cytotoxic T lymphocytes versus streptococcal colonization in periapical granulomas. (10425947)
1999
22
Focal cemento-osseous dysplasia in the maxilla mimicking periapical granuloma. (10442950)
1999
23
Interferon-gamma-producing cells and inducible nitric oxide synthase-producing cells in periapical granulomas. (9563799)
1998
24
Immune cells in periapical granuloma: morphological and immunohistochemical characterization. (1895036)
1991
25
Quantitative analysis of the immunocompetent cells in periapical granuloma: correlation with the histological characteristics of the lesions. (1974913)
1990
26
The role of acute phase proteins in the pathogenesis of chronic periapical granuloma]. (1698164)
1990
27
Acute phase proteins in patients with chronic periapical granuloma before and after surgical treatment. (3268759)
1988
28
Endodontic treatment and immunopathology of periapical granuloma in an AIDS patient. (2977755)
1988
29
In situ characterization of cells in periapical granuloma by monoclonal antibodies. (3477750)
1987
30
Bacteriological status of periapical granuloma. (6597195)
1984
31
Macrophages isolated from periapical granuloma: a scanning electron microscopic study. (6592531)
1984
32
Isolation and characterization of inflammatory cells from the human periapical granuloma. (6983538)
1982
33
Quantitative analysis of cellular composition of human periapical granuloma. (6938631)
1981
34
Reddening of the upper central incisors associated with periapical granuloma in lepromatous leprosy. (1063039)
1976
35
A colony of actinomyces-like organisms in a periapical granuloma. (4161341)
1966

Variations for Periapical Granuloma

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Expression for genes affiliated with Periapical Granuloma

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Search GEO for disease gene expression data for Periapical Granuloma.

Pathways for genes affiliated with Periapical Granuloma

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Pathways related to Periapical Granuloma according to GeneCards Suite gene sharing:

(show top 50)    (show all 70)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6TNF, MMP8, MMP13
2
Show member pathways
IL2 signaling events mediated by STAT536
9.5IL2RA, IL4, IL2
3
Show member pathways
9.4TNF, TNFRSF11B, TNFSF11
49.4IFNG, IL2RA, IL2
59.3IL4, IFNG, IL2
69.2TNF, IFNG, CCL2
79.2CCL2, IFNG, TNF
89.1IL2RA, IL2, CCL5, IL4, TNFSF11
9
Show member pathways
IL27-mediated signaling events36
9.1IFNG, TNF, IL2
109.1IFNG, IL4, IL2, IL2RA
11
Show member pathways
Type III interferon signaling36
9.1IL4, IFNG, IL2, IL2RA
129.1IL1A, TNF, IL4, IL2RA
13
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes59
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway59
9.0TNF, IL2RA, IL4, IL2
14
Show member pathways
8.9TNF, IFNG, IL1A, CCR5
158.9CCL2, TNF, CCL3
168.9NOS2, IFNG, TNF, IL1A
17
Show member pathways
Immune response MIF in innate immunity response59
8.9TNF, NOS2, IL1A, IFNG
18
Show member pathways
Ras signaling in the CD4+ TCR pathway36
8.8IL2, TNF, IFNG, IL2RA
198.8IFNG, IL2, TNF, NOS2
20
Show member pathways
Immune response CD16 signaling in NK cells59
8.8IFNG, IL4, IL2, TNF
21
Show member pathways
8.8IL4, IL2, CCL2, IL2RA, MDK
22
Show member pathways
Apoptosis and survival TNFR1 signaling pathway59
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
8.7TNF, TNFSF11, TNFRSF11B, CCL5, CCR5, CCL2
23
Show member pathways
8.6CCL3, CCL4, CCR5, CCL5
24
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
8.6TNF, IL4, IL1A, NOS2, IFNG
25
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
8.6NOS2, IL2, IFNG, CCL2, TNF
26
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
8.6IL2RA, IL2, IL4, IFNG, TNF
278.6TNFRSF11B, TNFSF11, IFNG, IL1A, TNF
288.6IL1A, TNFRSF11B, TNFSF11, TNF, IFNG
298.4IL2, TNF, IL4, IFNG, IL1A
308.4IFNG, IL1A, IL4, TNF, IL2
31
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
8.2IL2, IL1A, CCR5, IL4, IFNG, TNF
32
Show member pathways
8.2IL2RA, IL1A, IL2, IL4, IFNG, TNF
33
Show member pathways
8.2IL2RA, TNF, IFNG, IL4, IL2, IL1A
34
Show member pathways
8.1CXCR3, CCL2, CCR5, CCL4, CCL5, CCL3
35
Show member pathways
8.1CCL2, CCR5, CCL5, CCL4, CCL3, CXCR3
36
Show member pathways
8.1CCL3, CCL5, CCR5, CCL4, CCL2, CXCR3
37
Show member pathways
7.9IFNG, CCL3, CCL4, NOS2, IL1A
38
Show member pathways
7.9IL1A, IL4, CCR5, IFNG, IL2, TNF
397.9TNF, IL4, NOS2, IL1A, IL2, IFNG
40
Show member pathways
7.7TNF, CCL2, IL2RA, IL1A, CCL5, IFNG
417.6TNF, TNFSF11, CCL3, CCL2, IFNG, IL1A
42
Show member pathways
7.5CXCR3, CDH5, CCL5, MMP8, MMP13, CCR5
43
Show member pathways
7.4IL2, IFNG, IL2RA, CCL3, CCL4, TNF
44
Show member pathways
Immune response IL 12 induced IFN gamma production59
7.1CCL4, CCL3, CCR5, IFNG, IL4, IL2
45
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
6.9NOS2, IL2, IFNG, CCL4, CCL2, CCL5
46
Show member pathways
5.8MDK, TNF, CCL4, IL4, IL2, IL2RA
47
Show member pathways
5.6MDK, CXCR3, TNFSF11, TNF, IL1A, IL2RA
48
Show member pathways
5.6IL1A, TNF, TNFSF11, CXCR3, CCL3, CCL5
49
Show member pathways
5.3IL1A, IL2RA, IL2, IL4, TNF, TNFSF11
50
Show member pathways
5.3TNF, TNFSF11, CXCR3, CCL3, CCL5, CCL2

Compounds for genes affiliated with Periapical Granuloma

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Compounds related to Periapical Granuloma according to GeneCards Suite gene sharing:

(show top 50)    (show all 246)
idCompoundScoreTop Affiliating Genes
1mcp 1448.6CCL3, CCL5, CCL2, CCL4, CXCR3
2gold sodium thiomalate448.5IFNG, IL1A, IL2RA, IL2, TNF
3infliximab44 50 1110.5TNFRSF11B, TNFSF11, CXCR3, TNF, IFNG, IL4
4polymyxin b448.4IL1A, IL4, IFNG, CCL2, TNFRSF11B, TNFSF11
5mdms448.2CCL3, CCL4, CCL2, CCL5, CCR5
6pentoxifylline44 119.2IL2, IL1A, IL4, IFNG, TNF, IL2RA
7larc448.2IL1A, CCL4, CCR5, CCL2, CCL5, CCL3
8thalidomide44 50 60 1111.2IL1A, IL2RA, IL2, IFNG, CCL5, TNFRSF11B
9ccl444 289.1CCL4, CCR5, CCL2, CCL5, CCL3, CXCR3
10ivig448.0TNF, CCR5, CCL4, IFNG, IL4, IL2RA
11toxin-1448.0IL2, CCL3, CCL4, TNF, CCL2
12ribavirin44 50 119.8IL4, IL2, IFNG, CCR5, CCL3, CXCR3
13calcitriol44 60 24 1110.7TNF, IL2RA, IL1A, IFNG, IL4, TNFSF11
14mip 1alpha447.7IL4, CCL4, CCR5, CCL2, CCL5, CCL3
15polyinosinic-polycytidylic acid447.7IL4, IL1A, IL2, IFNG, CCL3, NOS2
16pdtc447.7IL4, IFNG, CCL2, CCL5, CCL3, TNF
17neopterin447.6IL1A, IL2RA, IL2, IL4, CCL3, TNF
18ly294002447.6CCL5, TNF, TNFSF11, NOS2, IL4, CCL2
19herbimycin a44 608.6MMP13, TNF, CCL2, IFNG, NOS2, HPSE
20gm-csf44 288.6IL1A, IL2, IL4, IFNG, CCL2, CCL5
21heparan sulfate44 248.5CCL5, CCL4, MDK, CCL3, TNFRSF11B, TNFSF11
22groalpha447.5CCL5, CCL3, CXCR3, MMP13, TNF, CCL2
23triptolide447.3NOS2, IL2, IFNG, CCL4, CCL5, CCL3
24ccl344 288.2CCL3, CXCR3, TNF, IL1A, IFNG, CCL4
25endotoxin447.2NOS2, IL1A, IFNG, CCL4, CCL2, CCL5
26prednisolone44 28 119.2TNF, TNFRSF11B, CCL3, CCL4, IFNG, IL2
27simvastatin44 50 60 28 24 1112.1IL1A, IL4, IFNG, CCL4, CCR5, CCL2
28hydrocortisone44 1 60 1110.0CDH5, IL1A, IL2, IL4, IFNG, CCL5
29actinomycin d447.0CCL2, TNF, NOS2, MMP13, CCL3, CCR5
30ionomycin447.0IL1A, IL2RA, IL2, IL4, IFNG, CCL4
31thymidine44 248.0CXCR3, TNF, MMP13, CCL3, IFNG, IL2RA
32tacrolimus44 50 118.9IL2RA, IL2, IL4, IFNG, CCL4, CCL5
33tarc446.9CCR5, CCL2, CCL5, CCL3, CXCR3, TNF
34genistein44 28 60 1 24 1111.9MMP8, CCL5, CCL2, IFNG, IL2, IL2RA
35oxygen44 247.8CXCR3, CCL3, CCL4, HPSE, NOS2, CDH5
36cysteine446.8TNFSF11, CCL3, CCL5, TNFRSF11B, MMP13, CCL4
37heparin44 28 24 119.5TNFSF11, TNFRSF11B, MMP13, CXCR3, CCL3, CCL5
38histamine44 28 248.4IL4, IFNG, CCL4, CCR5, CCL2, CCL5
39sb 20358044 607.3CCL5, CCL3, MMP13, TNFRSF11B, TNFSF11, TNF
40il 10446.3CCL4, CCR5, CCL2, CCL5, CCL3, CXCR3
41retinoic acid44 247.1CCR5, CCL3, MMP8, MMP13, TNF, CCL5
42cyclosporin a44 28 608.0IL1A, TNF, IL2RA, IL2, IL4, IFNG
43indomethacin44 28 60 118.9CCL5, CCL3, MMP13, TNFRSF11B, TNFSF11, TNF
44serine445.9CCL3, IL2, CCL4, MMP8, HPSE, TNFSF11
45cycloheximide445.8TNFRSF11B, CCL4, IFNG, IL4, IL1A, IL2
46nitric oxide44 24 117.6TNF, TNFSF11, TNFRSF11B, MMP13, MMP8, CXCR3
47rantes445.5TNFSF11, TNF, IL2RA, IL2, IL4, IFNG
48dexamethasone44 50 28 118.2TNF, TNFSF11, TNFRSF11B, MMP13, CXCR3, CCL3
49pge2445.0NOS2, CCR5, CCL2, CCL5, CCL4, IFNG
50vegf444.6IL2RA, IL1A, HPSE, NOS2, CDH5, IL2

GO Terms for genes affiliated with Periapical Granuloma

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Cellular components related to Periapical Granuloma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.5CXCR3, CCR5, IFNG, IL4, IL2RA, TNF
2extracellular spaceGO:00056155.3IL2, IL4, IFNG, CCL4, CCL2, CCL5
3extracellular regionGO:00055764.9MDK, TNF, HPSE, IL1A, IL2, IFNG

Biological processes related to Periapical Granuloma according to GeneCards Suite gene sharing:

(show top 50)    (show all 78)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of homotypic cell-cell adhesionGO:003411210.3CCL5, TNFSF11
2regulation of T cell homeostatic proliferationGO:004601310.2IL2, IL2RA
3chemokine-mediated signaling pathwayGO:007009810.1CCR5, CCL2, CCL5
4innate immune response in mucosaGO:000222710.1NOS2, IL4
5positive regulation of killing of cells of other organismGO:005171210.1IFNG, NOS2
6positive regulation of activated T cell proliferationGO:00421049.9IL2RA, IL2, IL4
7positive regulation of hair follicle developmentGO:00517989.9TNF, HPSE
8positive regulation of vitamin D biosynthetic processGO:00605579.9IFNG, TNF
9positive regulation of T cell proliferationGO:00421029.8IFNG, CCL5, IL4
10positive regulation of calcidiol 1-monooxygenase activityGO:00605599.8TNF, IFNG
11signalingGO:00230529.8CCL3, CCR5
12positive regulation of isotype switching to IgG isotypesGO:00483049.8IL2, IFNG, IL4
13extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.7IL1A, IL2, IL4
14positive regulation of MHC class II biosynthetic processGO:00453489.7IFNG, IL4
15cellular response to lipopolysaccharideGO:00712229.7CCL2, IFNG, NOS2, CCR5
16positive regulation of osteoclast differentiationGO:00456729.7IFNG, TNFSF11, TNF
17positive regulation of chemokine biosynthetic processGO:00450809.6IFNG, IL4, TNF
18T cell chemotaxisGO:00108189.6CXCR3, CCL3
19release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:00148089.6CCR5, CCL3
20macrophage chemotaxisGO:00482469.6CCL2, CCL5, CCL3
21cellular response to interleukin-1GO:00713479.5CCL2, CCL5, CCL3
22humoral immune responseGO:00069599.5CCL2, IFNG, TNF
23cell surface receptor signaling pathwayGO:00071669.5CXCR3, IL2RA, IFNG, CCR5, CCL2
24astrocyte cell migrationGO:00436159.5CCL3, CCL2
25cellular response to tumor necrosis factorGO:00713569.4CCL5, CCL2, CCL3
26monocyte chemotaxisGO:00025489.4TNFSF11, CCL3, CCL2, CCL5
27lymphocyte chemotaxisGO:00482479.4CCL2, CCL3
28cytokine-mediated signaling pathwayGO:00192219.4TNFSF11, IFNG, CCL2, IL1A
29cellular response to interferon-gammaGO:00713469.4CCL3, NOS2, CCL2, CCL5
30neutrophil chemotaxisGO:00305939.3IFNG, CCL2, CCL3
31positive regulation of natural killer cell chemotaxisGO:020005039.3CCL3, CCL5, CCL4
32negative regulation by host of viral transcriptionGO:00439229.2CCL4, CCL3, CCL5
33positive regulation of calcium ion transportGO:00519289.2CCL4, CCL5, CCL3
34calcium-mediated signalingGO:00197229.1CCR5, CXCR3, TNF, CCL3
35response to cholesterolGO:00707239.1CCR5, CCL3
36lipopolysaccharide-mediated signaling pathwayGO:00316639.1TNF, CCL5, CCL2, CCL3
37protein kinase B signalingGO:00434919.1CCL2, CCL3, TNF, CCL5
38cellular response to organic cyclic compoundGO:00714079.1TNF, CCL3, CCL2, CCL5
39response to virusGO:00096159.0CCL5, TNF, CCL4, IFNG
40cell activationGO:00017759.0CCL3, TNF
41positive regulation of protein kinase B signalingGO:00518979.0CCL3, TNFSF11, TNF, HPSE
42chemotaxisGO:00069358.9IL4, CXCR3, CCL2, CCL5, CCL3, CCR5
43response to toxic substanceGO:00096368.9CCL5, CCL4, CCL3
44MAPK cascadeGO:00001658.9CCL2, CCL5, CCL3, TNF, CCR5
45apoptotic processGO:00069158.7IFNG, IL1A, IL2RA, TNF, TNFRSF11B, CXCR3
46cell-cell signalingGO:00072678.6CCL3, CCR5, CCL5, IL2, CCL4
47immune responseGO:00069558.5IL1A, IL2RA, IL2, IL4, CCL4, CCR5
48response to drugGO:00424938.5IL4, IFNG, CCL2, TNFRSF11B, TNF, MDK
49positive regulation of transcription from RNA polymerase II promoterGO:00459448.4TNF, TNFSF11, CXCR3, IFNG, IL4, IL2
50inflammatory responseGO:00069547.4CCL3, CCL5, TNF, CCL2, CCR5, IL1A

Molecular functions related to Periapical Granuloma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:000495010.1CCR5, CXCR3
2phospholipase activator activityGO:00160049.1CCL5, CCL3
3CCR5 chemokine receptor bindingGO:00317308.9CCL3, CCL5, CCL4
4CCR1 chemokine receptor bindingGO:00317268.8CCL3, CCL5, CCL4
5chemokine activityGO:00080098.5CCL3, CCL5, CCL2, CCL4
6cytokine activityGO:00051257.4IL1A, TNF, TNFSF11, TNFRSF11B, CCL4, IFNG

Sources for Periapical Granuloma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet