MCID: PRP002
MIFTS: 31

Periapical Granuloma malady

Category: Oral diseases

Aliases & Classifications for Periapical Granuloma

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Aliases & Descriptions for Periapical Granuloma:

Name: Periapical Granuloma 11 50 39 13 68
 
Apical Granuloma 11

Classifications:



External Ids:

Disease Ontology11 DOID:4617
SNOMED-CT62 196344002, 81407003
MeSH39 D010484

Summaries for Periapical Granuloma

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MalaCards based summary: Periapical Granuloma, also known as apical granuloma, is related to breast intracanalicular fibroadenoma and hidradenitis suppurativa. An important gene associated with Periapical Granuloma is TNFSF11 (TNF Superfamily Member 11), and among its related pathways are Interleukin-10 signaling and Lung fibrosis. Affiliated tissues include endothelial, neutrophil and t cells, and related mouse phenotype Decreased shRNA abundance (Z-score < -2).

Related Diseases for Periapical Granuloma

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Diseases related to Periapical Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
idRelated DiseaseScoreTop Affiliating Genes
1breast intracanalicular fibroadenoma10.1CXCL8, TNFSF11
2hidradenitis suppurativa10.1CCL5, CXCL8
3infectious anterior uveitis10.1CCL5, CXCL8
4erb-duchenne and dejerine-klumpke palsies10.1CCL5, CXCL8
5mixed mineral dust pneumoconiosis10.1CCL5, CXCL8
6patellar tendinitis10.1CCL5, CXCL8
7hyperimmunoglobulin syndrome10.1CCL5, CXCL8
8breast apocrine carcinoma in situ10.1CCL5, CXCL8
9vitreoretinopathy, neovascular inflammatory10.0CXCL8, MMP8
10choroiditis10.0CP, CXCL8
11classic type lipoma10.0CXCL8, TNFSF11
12vascular dementia10.0MMP8, TNFSF11
13burns10.0CXCL8, MMP8
14infancy electroclinical syndrome10.0CXCL8, MMP8
15stenosis of lacrimal sac10.0CXCL8, MMP8
16baritosis10.0CP, CXCL8
17unilateral hypoactive labyrinth10.0CXCL8, MMP8
18mast-cell leukemia10.0CCL5, CXCL8
19pityriasis rosea10.0MMP13, MMP8
20fasciitis9.9CXCL8, MMP8
21autosomal recessive type iv ehlers-danlos syndrome9.9CXCL8, MMP8, TNFSF11
22pulmonary tuberculosis9.9CCL5, CXCL8
23fungal gastritis9.9CXCL8, MMP8, TNFSF11
24histiocytosis9.9CXCL8, MMP8, TNFSF11
25paragonimiasis9.9CCL5, CP, CXCL8
26spontaneous ocular nystagmus9.8CCL5, CXCL8
27synovium cancer9.8CXCL8, MMP13, TNFSF11
28bone angioendothelial sarcoma9.8CXCL8, MMP13, TNFSF11
29osteonecrosis9.8CXCL8, MMP13, TNFSF11
30autistic disorder9.8CXCL8, MMP13, TNFSF11
31leprosy9.7
32lepromatous leprosy9.7
33endotheliitis9.7
34rheumatoid arthritis9.6CCL5, CXCL8, MMP13, TNFSF11
35intratubular embryonal carcinoma9.6CXCL8, MMP13, MMP8, TNFSF11
36nasal cavity inverting papilloma9.1CCL5, CDH5, CP, CXCL8, MMP13, MMP8

Graphical network of the top 20 diseases related to Periapical Granuloma:



Diseases related to periapical granuloma

Symptoms & Phenotypes for Periapical Granuloma

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GenomeRNAi Phenotypes related to Periapical Granuloma according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-846.7CDH5, MMP8, TNFSF11, CCL5, MMP13, TNFSF11

Drugs & Therapeutics for Periapical Granuloma

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Drugs for Periapical Granuloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Mepivacaineapproved, vet_approved6596-88-84062
Synonyms:
(+-)-1-Methyl-2',6'-pipecoloxylidide
1-METHYL-2',6'-PIPECOLOXYLIDIDE
1-methyl-2',6'-pipecoloxylidide
1722-62-9 (mono-hydrochloride)
22801-44-1
34811-66-0
5-22-01-00223 (Beilstein Handbook Reference)
96-88-8
AC-15503
AC1L1HBV
Arestocaine HCL
BRD-A03216249-003-02-9
BRN 0211230
BSPBio_003297
C07528
CHEBI:6759
CHEMBL1087
CID4062
Carbocaine
Carboplyin Dental
Carboplyin Dental (TN)
D(-)-Mepivacaine
D-mepivacaine
D08181
DB00961
DL-Mepivacaine
DivK1c_006970
EINECS 202-543-0
I01-1864
Isocaine HCL
KBio1_001914
KBio2_001960
KBio2_004528
KBio2_007096
 
KBio3_002517
KBioGR_001092
KBioSS_001960
LS-109848
LS-109849
Mepivacaina
Mepivacaina [INN-Spanish]
Mepivacaine (INN)
Mepivacaine HCL
Mepivacaine [INN:BAN]
Mepivacaine hydrochloride
Mepivacainum
Mepivacainum [INN-Latin]
Mepivicaine
MolPort-005-935-383
N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide
N-(2,6-Dimethylphenyl)-1-methylpiperidine-2-carboxamide
N-Methyl-2-pipecolic acid, 2,6-dimethylanilide
N-Methyl-2-pipecolic acid, 2,6-xylidide
N-Methylhexahydro-2-picolinic acid, 2,6-dimethylanilide
NCGC00089774-02
Polocaine-Mpf
S-Ropivacaine Mesylate
SPBio_001811
Scandicain
Scandicaine
Scandicane
SpecPlus_000874
Spectrum2_001656
Spectrum3_001629
Spectrum4_000596
Spectrum5_001354
Spectrum_001480
UNII-B6E06QE59J
mepivacaine
2Central Nervous System Depressants13403
3Anesthetics, Local3492
4Anesthetics9596

Interventional clinical trials:

idNameStatusNCT IDPhase
1RCT: Effectiveness of a Microscope During Dental Root Apical SurgeryUnknown statusNCT01759069
2Evaluation of Anesthetic Efficacy in Extraction on Mandibular MolarsNot yet recruitingNCT03106168

Search NIH Clinical Center for Periapical Granuloma


Cochrane evidence based reviews: periapical granuloma

Genetic Tests for Periapical Granuloma

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Anatomical Context for Periapical Granuloma

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MalaCards organs/tissues related to Periapical Granuloma:

36
Endothelial, Neutrophil, T cells, Monocytes, Colon, Bone

Publications for Periapical Granuloma

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Articles related to Periapical Granuloma:

(show all 36)
idTitleAuthorsYear
1
Expression of interleukin-33 and its receptor ST2 in periapical granulomas and radicular cysts. (25677987)
2016
2
Bioinformatics, Interaction Network Analysis, and Neural Networks to Characterize Gene Expression of Radicular Cyst and Periapical Granuloma. (25873079)
2015
3
Expression and immunohistochemical localization of leptin receptor in human periapical granuloma. (25081278)
2014
4
Heparanase expression in periapical granulomas and radicular cysts. (22020734)
2013
5
Oral pathology quiz #81. Case number 4. Dental (periapical) granuloma. (24597181)
2013
6
Periapical granuloma associated with extracted teeth. (22037071)
2011
7
Midkine expression in human periapical granulomas. (21787488)
2011
8
T-helper cell type 17/regulatory T-cell immunoregulatory balance in human radicular cysts and periapical granulomas. (20478453)
2010
9
Distinct Th1, Th2 and Treg cytokines balance in chronic periapical granulomas and radicular cysts. (20102461)
2010
10
High matrix metalloproteinase activity is a hallmark of periapical granulomas. (19720222)
2009
11
Differential patterns of receptor activator of nuclear factor kappa B ligand/osteoprotegerin expression in human periapical granulomas: possible association with progressive or stable nature of the lesions. (18634923)
2008
12
Antrochoanal polyp derived from periapical granuloma. (18701055)
2008
13
Involvement of inducible nitric oxide synthase and receptor for advanced glycation end products in periapical granulomas. (17258631)
2007
14
RANKL in human periapical granuloma: possible involvement in periapical bone destruction. (16700737)
2006
15
Co-production of vascular endothelial cadherin and inducible nitric oxide synthase by endothelial cells in periapical granuloma. (16507070)
2006
16
Oral diagnosis. Interradicular radiolucency of maxilla. Periapical granuloma. (16161239)
2005
17
Intraneural epithelial islands associated with a periapical granuloma: a cause for concern? (12796887)
2003
18
Evaluation of immunoglobulin G synthesizing plasma cells in periapical granuloma and cyst. (11441800)
2001
19
The presence of chemokine receptor (CCR5, CXCR3, CCR3)-positive cells and chemokine (MCP1, MIP-1alpha, MIP-1beta, IP-10)-positive cells in human periapical granulomas. (11683586)
2001
20
Hydrogen peroxide and superoxide anion production by polymorphonuclear neutrophils in patients with chronic periapical granuloma, before and after surgical treatment. (11355101)
2001
21
Differential in situ distribution of interleukin-8, monocyte chemoattractant protein-1 and Rantes in human chronic periapical granuloma. (11155167)
2000
22
Cytotoxic T lymphocytes versus streptococcal colonization in periapical granulomas. (10425947)
1999
23
Focal cemento-osseous dysplasia in the maxilla mimicking periapical granuloma. (10442950)
1999
24
Interferon-gamma-producing cells and inducible nitric oxide synthase-producing cells in periapical granulomas. (9563799)
1998
25
Immune cells in periapical granuloma: morphological and immunohistochemical characterization. (1895036)
1991
26
Quantitative analysis of the immunocompetent cells in periapical granuloma: correlation with the histological characteristics of the lesions. (1974913)
1990
27
The role of acute phase proteins in the pathogenesis of chronic periapical granuloma]. (1698164)
1990
28
Acute phase proteins in patients with chronic periapical granuloma before and after surgical treatment. (3268759)
1988
29
Endodontic treatment and immunopathology of periapical granuloma in an AIDS patient. (2977755)
1988
30
In situ characterization of cells in periapical granuloma by monoclonal antibodies. (3477750)
1987
31
Bacteriological status of periapical granuloma. (6597195)
1984
32
Macrophages isolated from periapical granuloma: a scanning electron microscopic study. (6592531)
1984
33
Isolation and characterization of inflammatory cells from the human periapical granuloma. (6983538)
1982
34
Quantitative analysis of cellular composition of human periapical granuloma. (6938631)
1981
35
Reddening of the upper central incisors associated with periapical granuloma in lepromatous leprosy. (1063039)
1976
36
A colony of actinomyces-like organisms in a periapical granuloma. (4161341)
1966

Variations for Periapical Granuloma

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Expression for genes affiliated with Periapical Granuloma

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Search GEO for disease gene expression data for Periapical Granuloma.

Pathways for genes affiliated with Periapical Granuloma

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GO Terms for genes affiliated with Periapical Granuloma

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Cellular components related to Periapical Granuloma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.9CCL5, CP, CXCL8, MMP13, MMP8, TNFSF11
2extracellular spaceGO:00056157.2CCL5, CP, CXCL8, MMP13, MMP8, TNFSF11

Biological processes related to Periapical Granuloma according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1monocyte chemotaxisGO:000254810.2CCL5, TNFSF11
2calcium-mediated signalingGO:001972210.2CXCL8, TNFSF11
3cellular response to fibroblast growth factor stimulusGO:004434410.1CCL5, CXCL8
4cellular response to interleukin-1GO:007134710.1CCL5, CXCL8
5chemokine-mediated signaling pathwayGO:007009810.1CCL5, CXCL8
6positive regulation of homotypic cell-cell adhesionGO:003411210.1CCL5, TNFSF11
7negative regulation of G-protein coupled receptor protein signaling pathwayGO:004574410.0CCL5, CXCL8
8neutrophil activationGO:004211910.0CCL5, CXCL8
9neutrophil chemotaxisGO:00305939.8CCL5, CXCL8
10collagen catabolic processGO:00305749.8MMP13, MMP8
11extracellular matrix disassemblyGO:00226179.8MMP13, MMP8
12positive regulation of phosphorylationGO:00423279.7CCL5, TNFSF11
13immune responseGO:00069559.6CCL5, CXCL8, TNFSF11

Molecular functions related to Periapical Granuloma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:000800910.0CCL5, CXCL8
2cytokine activityGO:00051259.1CCL5, CXCL8, TNFSF11

Sources for Periapical Granuloma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet