Periapical Granuloma malady

MalaCards: Periapical Granuloma, also known as apical granuloma (disorder), is related to malignant ovarian cyst and hiv infection, resistance to. An important gene associated with Periapical Granuloma is CXCR3 (chemokine (C-X-C motif) receptor 3), and among its related pathways are OX40 Pathway and Graft-versus-host disease. The compounds ionomycin and ivig have been mentioned in the context of this disorder. Affiliated tissues include monocytes, t cells and b cells, and related mouse phenotypes are craniofacial and hematopoietic system.

Aliases & Descriptions:

periapical granuloma 6 32 43 apical granuloma (disorder) 6

Diseases related to periapical granuloma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 568)

id	Related Disease	Score	Top Affiliating Genes
1	malignant ovarian cyst	13.5	MMP13, MMP8
2	hiv infection, resistance to	13.5	CCR5, CCL3
3	bacterial meningitis	13.4	MMP8, CCL4, CCL3
4	viral meningitis	13.4	CCL5, CXCR3
5	erdheim-chester disease	13.3	CCL4, CCL2, CCR5
6	chromoblastomycosis	13.3	IL4, CCL3, CXCR3
7	intermediate uveitis	13.3	IL2RA, CCR5, CXCR3
8	carotid artery disease	13.3	MMP8, CCL2, CCL5
9	respiratory syncytial virus infectious disease	13.3	CCL3, CCL5
10	dengue disease	13.3	CCL4, CCL3, CCL5
11	chronic apical periodontitis	13.3	TNFRSF11B, TNFSF11
12	mast-cell leukemia	13.3	CCL2, CCL3, CCL5
13	paget disease, juvenile	13.3	TNFRSF11B, TNFSF11
14	polyostotic osteolytic dysplasia, hereditary expansile	13.3	TNFRSF11B, TNFSF11
15	coronary arteriosclerosis	13.3	CCL2, CCR5, CCL5
16	central nervous system disease	13.3	CCL2, CCR5, CXCR3
17	vernal keratoconjunctivitis	13.3	IL4, CCL5, CXCR3
18	osteopenia/osteoporosis	13.2	TNFRSF11B, TNFSF11
19	smallpox	13.2	IL4, CCR5, CXCR3
20	genital herpes	13.2	IL4, CCL3, CCL5
21	peripheral t-cell lymphoma	13.2	IL2RA, NOS2, CXCR3
22	intrinsic asthma	13.2	IL4, CCL5
23	aggressive periodontitis	13.1	MMP8, IL1A
24	icos deficiency	13.1	IFNG, TNFSF11
25	hepatic fibrosis renal cysts mental retardation	13.1	MMP13, MMP8, CCL2, CCR5
26	ulceration of vulva	13.1	MMP13, MMP8, CCR5, CCL5
27	primary systemic mycosis	13.1	IL4, TNF
28	bullous skin disease	13.1	CCL5, TNF
29	stachybotrys chartarum	13.1	IL1A, CCL4, CCL3
30	tuberculoid leprosy	13.1	IL2RA, IFNG
31	contact dermatitis	13.1	IL1A, CXCR3
32	monoclonal gammopathy of undetermined significance	13.0	CCL3, TNFRSF11B, TNFSF11
33	idiopathic myopathy	13.0	IL1A, CCL2, CCL5
34	aneurysm disease	13.0	MMP8, CCL2, TNFRSF11B
35	alexithymia	13.0	IL4, CCL4, CCR5, CCL3
36	whiplash	13.0	CCR5, IFNG
37	mycobacterium tuberculosis	13.0	CCL2, TNF
38	pulmonary alveolar proteinosis	13.0	CCL4, CCL2, TNF
39	radiculopathy	13.0	IL1A, IL2RA, CXCR3
40	localized scleroderma	13.0	MMP13, IL2RA, IL4, CCL5
41	factor v leiden thrombophilia	13.0	MMP13, MMP8, CCL5, TNFSF11
42	nonspecific interstitial pneumonia	13.0	CCL2, IFNG, CXCR3
43	sympathetic ophthalmia	13.0	CCL2, TNF
44	abdominal aortic aneurysm	13.0	MMP13, MMP8, CCL2, TNFRSF11B
45	retinal vasculitis	13.0	CCL4, TNF, NOS2
46	diabetic angiopathy	13.0	CCL2, TNFRSF11B, NOS2
47	relapsing polychondritis	13.0	CCL4, CCL2, IFNG
48	cryptosporidiosis	12.9	IL1A, IL4, CCL5
49	anterior uveitis	12.9	CCL2, CCL5, TNF
50	african tick-bite fever	12.9	CCL3, CCL5, IFNG

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to periapical granuloma:

²²

MGI Mouse Phenotypes related to periapical granuloma:

²⁵ (show all 14)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial phenotype	MP:0005382	10.2	CDH5
2	hematopoietic system phenotype	MP:0005397	9.7	TNFSF11, MDK, CDH5
3	skeleton phenotype	MP:0005390	9.3	TNFSF11, TNFRSF11B, MMP13
4	digestive/alimentary phenotype	MP:0005381	8.8	NOS2, IFNG, CCL3, CCR5, CCL2
5	integument phenotype	MP:0010771	8.5	CDH5, MMP13, IL4, IFNG, TNFSF11
6	liver/biliary system phenotype	MP:0005370	8.5	IFNG, CCR5, MDK, IL2
7	growth/size phenotype	MP:0005378	8.4	TNFSF11, TNFRSF11B, IL2RA, IL2, MMP13, CDH5
8	homeostasis/metabolism phenotype	MP:0005376	8.1	CXCR3, NOS2, TNFSF11, CCL3, CCR5, CCL2
9	reproductive system phenotype	MP:0005389	7.6	NOS2, TNFSF11, TNF, IFNG, CCR5, CCL2
10	immune system phenotype	MP:0005387	7.5	CDH5, TNF, IFNG, CCL3, MDK, IL2
11	tumorigenesis	MP:0002006	7.0	CXCR3, NOS2, TNF, IFNG, CCR5, CCL2
12	cardiovascular system phenotype	MP:0005385	5.8	CXCR3, NOS2, TNFRSF11B, TNF, IFNG, CCR5
13	mortality/aging	MP:0010768	5.5	TNF, TNFRSF11B, TNFSF11, NOS2, CXCR3, IFNG
14	cellular phenotype	MP:0005384	4.9	CCL5, IFNG, TNF, TNFRSF11B, TNFSF11, NOS2

Articles related to periapical granuloma:

(show all 12)

id	Title	Authors	Year	Affiliating Genes
1	Midkine expression in human periapical granulomas. (21787488)	Hatori K.... Komiyama K.	2011	MDK
2	T-helper cell type 17/regulatory T-cell immunoregulat ory balance in human radicular cysts and periapical granulomas. (20478453)	MarAsal J.R.... Rodrigues D.B.	2010	CCL2
3	Distinct Th1, Th2 and Treg cytokines balance in chron ic periapical granulomas and radicular cysts. (20102461)	Teixeira-Salum T.B.... Loyola A.M.	2010	TNF, IL4, IFNG
4	High matrix metalloproteinase activity is a hallmark of periapical granulomas. (19720222)	de Paula-Silva F.W.... Kapila Y.L.	2009	MMP13
5	Differential patterns of receptor activator of nuclear factor kappa B ligand/osteoprotegerin expression in human periapical granulomas: possible association with progressive or stable nature of the lesions. (18634923)	Menezes R.... Garlet G.P.	2008	TNFRSF11B, TNFSF11
6	Involvement of inducible nitric oxide synthase and receptor for advanced glycation end products in periapical granulomas. (17258631)	Hama S.... Ito K.	2007	NOS2
7	RANKL in human periapical granuloma: possible involvement in periapical bone destruction. (16700737)	Vernal R.... Gamonal J.	2006	TNFSF11
8	Co-production of vascular endothelial cadherin and inducible nitric oxide synthase by endothelial cells in periapical granuloma. (16507070)	Hama S.... Ito K.	2006	CDH5, NOS2
9	The presence of chemokine receptor (CCR5, CXCR3, CCR3)-positive cells and chemokine (MCP1, MIP-1alpha, MIP-1beta, IP-10)-positive cells in human periapical granulomas. (11683586)	Kabashima H.... Maeda K.	2001	CCR5, CCL2, CXCR3
10	Differential in situ distribution of interleukin-8, monocyte chemoattractant protein-1 and Rantes in human chronic periapical granuloma. (11155167)	Marton I.J.... Kiss C.	2000	CCL2, CCL5
11	Interferon-gamma-producing cells and inducible nitric oxide synthase-producing cells in periapical granulomas. (9563799)	Kabashima H.... Iijima T.	1998	IL1A
12	Immune cells in periapical granuloma: morphological a nd immunohistochemical characterization. (1895036)	Piattelli A.... Musiani P.	1991	IL2

Genes related to periapical granuloma according to GeneCards:

(show all 19)

id	Symbol	Description	Score	GeneCards Section Context
1	CXCR3	chemokine (C-X-C motif) receptor 3	11.0	Publications
2	MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	11.0
3	MMP13	matrix metallopeptidase 13 (collagenase 3)	11.0	Publications
4	CCL4	chemokine (C-C motif) ligand 4	11.0	Publications
5	TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	11.0	Publications
6	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
7	CCL3	chemokine (C-C motif) ligand 3	11.0	Publications
8	CCL5	chemokine (C-C motif) ligand 5	11.0	Publications
9	CCR5	chemokine (C-C motif) receptor 5 (gene/pseudogene)	11.0	Publications
10	NOS2	nitric oxide synthase 2, inducible	11.0	Publications
11	IL4	interleukin 4	11.0	Publications
12	IL2RA	interleukin 2 receptor, alpha	11.0
13	MDK	midkine (neurite growth-promoting factor 2)	11.0	Publications
14	CDH5	cadherin 5, type 2 (vascular endothelium)	11.0	Publications
15	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	11.0	Publications
16	IL1A	interleukin 1, alpha	11.0	Publications
17	TNF	tumor necrosis factor	11.0	Publications
18	IFNG	interferon, gamma	11.0	Publications
19	IL2	interleukin 2	11.0	Publications

Pathways related to periapical granuloma according to GeneDecks:

(show top 50)    (show all 75)

id	Pathway	Score	Top Affiliating Genes
1	OX40 Pathway36	10.2	IL4
2	Graft-versus-host disease20	9.7	IL1A, IL2
3	RAR-Gamma-RXR-Alpha Degradation36	9.6	CCL5, CCL3, CCL4, IL2
4	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.5	CCL3, CCL4, IL2RA, IL2
5	CCR5 Pathway in Macrophages36	9.5	CCL5, CCL3, CCR5, CCL4
6	Molecular Mechanisms of Cancer36	9.5	TNFSF11, CCL5, MDK, IL2
7	JNK Pathway36	9.4	CCL3, CCL4, IL2RA, IL2
8	IL-6 Pathway36	9.4	TNFSF11, CCL5, CCL3, CCL2, CCL4, IL4
9	Chemokine Signaling36	9.3	CXCR3, CCL5, CCL3, CCR5, CCL2, CCL4
10	Chemokine signaling pathway20	9.3	CXCR3, CCL5, CCL3, CCR5, CCL2, CCL4
11	LDL Oxidation in Atherogenesis36	9.3	TNF, CCL3, CCL2
12	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.0	TNF, IL2RA, IL2
13	NFAT Signaling and Lymphocyte Interactions36	8.8	CCL3, CCL2, CCL4, IL4, IL2, IL1A
14	PGC1Alpha Pathway36	8.8	CCL5, CCL3, CCL4, IL4, IL2, IL1A
15	Endothelin-1 Signaling Pathway36	8.8	TNFSF11, CCL5, CCL3, IL4, IL2, IL1A
16	Transendothelial Migration of Leukocytes36	8.6	CXCR3, CCL5, CCL3, CCR5, CCL2, CCL4
17	SOCS Pathway36	8.5	CCL5, CCL3, CCL2, CCL4, IL4, IL2
18	Immune response_MIF-mediated glucocorticoid regulation41	8.5	NOS2, TNF, IFNG, IL2
19	Regulation of eIF4 and p70S6K36	8.5	CCL5, CCL3, CCL2, CCL4, IL4, IL2
20	Immune response MIF-mediated glucocorticoid regulation10	8.5	NOS2, TNF, IFNG, IL2
21	Allograft rejection20	8.4	TNF, IFNG, IL4, IL2
22	Hematopoietic cell lineage20	8.4	IL1A, IL2RA, IL4, TNF
23	Chagas disease (American trypanosomiasis)20	8.3	NOS2, TNF, IFNG, CCL5, CCL3, CCL2
24	Leishmaniasis20	8.2	NOS2, TNF, IFNG, IL4, IL1A
25	Type I diabetes mellitus20	8.2	TNF, IFNG, IL2, IL1A
26	THC Differentiation Pathway36	8.2	TNF, IFNG, IL4, IL2RA, IL2
27	Glucocorticoid Receptor Signaling36	8.2	CCL5, CCL3, CCL2, CCL4, IL4, IL2RA
28	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	8.2	TNFSF11, TNFRSF11B, TNF, IFNG, IL1A
29	Transcription Role of VDR in regulation of genes involved in osteoporosis10	8.1	IL1A, IFNG, TNF, TNFRSF11B, TNFSF11
30	Influenza A20	8.1	IL1A, CCL2, CCL5, IFNG, TNF
31	Measles20	8.1	IFNG, IL4, IL2RA, IL2, IL1A
32	Cytokine Network36	8.0	TNF, IFNG, IL4, IL2, IL1A
33	Osteoclast differentiation20	8.0	IL1A, IFNG, TNF, TNFRSF11B, TNFSF11
34	Tec Kinases Signaling36	7.9	CXCR3, CCL5, CCL3, CCR5, CCL2, CCL4
35	Rheumatoid arthritis20	7.9	TNFSF11, TNF, IFNG, CCL5, CCL3, CCL2
36	TGF-Beta Pathway36	7.8	CCL5, CCL3, CCL2, CCL4, MDK, IL4
37	MIF Mediated Glucocorticoid Regulation36	7.7	CCL3, CCL5, TNF, TNFSF11, CCL2, CCL4
38	MIF Regulation of Innate Immune Cells36	7.7	IL1A, IL2, IL4, CCL4, CCL2, CCL3
39	PEDF Induced Signaling36	7.7	IL2, IL4, CCL4, CCL2, CCL3, CCL5
40	all-trans-Retinoic Acid Signaling in Brain36	7.7	TNFSF11, IL1A, IL2, IL4, CCL4, CCL2
41	ERK Signaling36	7.3	TNFSF11, TNF, CCL5, CCL3, CCL2, CCL4
42	MAPK Family Pathway36	7.2	CCL2, CCL3, CCL5, TNF, CCL4, MDK
43	Akt Signaling36	7.0	IL4, IL2RA, IL2, MDK, CCL4, CCL2
44	PAK Pathway36	7.0	IL1A, IL2, IL2RA, IL4, MDK, CCL4
45	JAK-STAT Pathway36	7.0	IFNG, CCL5, CCL3, CCL2, CCL4, MDK
46	STAT3 Pathway36	6.9	IL2, IL1A, IL2RA, IL4, CCL4, CXCR3
47	Rho Family GTPases36	6.9	TNFSF11, TNF, CCL5, CCL3, CCL2, CCL4
48	p38 Signaling36	6.5	CXCR3, TNFSF11, TNF, CCL5, CCL3, CCR5
49	Antioxidant Action of Vitamin-C36	6.5	CXCR3, TNFSF11, TNF, CCL5, CCL3, CCR5
50	Cytokine-cytokine receptor interaction20	5.6	IL1A, CXCR3, TNFSF11, TNFRSF11B, TNF, IFNG

Compounds related to periapical granuloma according to GeneDecks:

(show top 50)    (show all 195)

id	Compound	Score	Top Affiliating Genes
1	ionomycin32	10.4	CCL3, CCL4
2	ivig32	10.3	CCR5, CCL4
3	endotoxin32	10.2	CXCR3, CCL3, CCL4
4	mcp 132	9.6	CCL5, CCL4, CCL2, CCL3, CXCR3
5	mdms32	9.4	CCL5, CCL3, CCR5, CCL2, CCL4
6	calcitriol32 42 9 18 9	13.0	TNFSF11, TNFRSF11B, CCL5, IL2RA, IL2
7	ccl432	9.0	CCL3, CXCR3, MMP13, CCL4, CCL2, CCR5
8	larc32	8.9	CCL5, CCL3, CCR5, CCL2, CCL4, IL1A
9	toxin-132	8.9	CCL2, CCL4, IL2, TNF, CCL3
10	heparin32 9 18 9	11.9	CCL5, TNFRSF11B, TNFSF11, MMP13, CXCR3, MDK
11	pge232	8.6	TNFSF11, TNFRSF11B, CCL5, CCL3, CCL4, IL1A
12	mip 1alpha32	8.5	TNFSF11, TNF, CCL5, CCL3, CCR5, CCL2
13	ribavirin32 34 9 9	11.3	IL4, IFNG, CCL3, IL2, CCR5, CXCR3
14	interferon gamma32	8.2	IL2, IL4, IFNG, TNF
15	heparan sulfate32 18	9.2	CXCR3, TNFSF11, TNFRSF11B, CCL5, CCL3, CCL4
16	groalpha32	8.1	CCL2, CCL4, IL1A, MMP13, CCR5, CCL3
17	sb 20358032 42	9.1	TNFSF11, TNFRSF11B, TNF, IFNG, CCL5, CCL4
18	il-1232	8.1	IL2, IFNG, TNF, IL4, CCL2
19	cysteine32	7.9	CCL4, TNFSF11, CCL5, CCL3, IFNG, MMP13
20	gold sodium thiomalate32	7.9	IL2, IL2RA, IFNG, TNF, IL1A
21	ly29400232	7.9	NOS2, TNFRSF11B, TNF, CXCR3, TNFSF11, CCL5
22	vegf32	7.9	CCL4, CCL2, CCL3, CCL5, TNFRSF11B, TNFSF11
23	infliximab32 9 9	9.8	TNFRSF11B, IFNG, IL4, TNF, CXCR3, IL2RA
24	polymyxin b32	7.6	TNFSF11, IFNG, CCL2, IL1A, TNFRSF11B, IL4
25	triptolide32	7.6	NOS2, TNF, IFNG, CCL5, CCL3, CCL2
26	pdtc32	7.5	CCL2, IL4, IL1A, NOS2, CCL3, CCL5
27	ccl332	7.5	CCL2, CCL4, IL1A, CCR5, CCL3, CCL5
28	pentoxifylline32 9 9	9.5	IL2, IL4, IFNG, IL1A, IL2RA, TNF
29	polyinosinic-polycytidylic acid32	7.5	IL1A, IL2, CCL3, IFNG, TNF, NOS2
30	neopterin32	7.4	IFNG, CCL3, IL4, TNF, IL2RA, IL2
31	prednisolone32 9 9	9.3	IFNG, MMP13, IL2, IL2RA, CCL4, CCL3
32	gm-csf32	7.3	TNF, IFNG, CCL5, CCL3, CCL2, IL4
33	simvastatin32 34 42 9 18 9	12.3	CCR5, CCL3, IFNG, IL1A, TNF, CCL5
34	tarc32	7.2	CXCR3, TNF, IFNG, CCL5, CCL3, CCR5
35	tacrolimus32 34 9 9	10.1	CXCR3, TNFSF11, TNF, IFNG, CCL5, CCL3
36	herbimycin a32 42	7.9	IL1A, NOS2, IFNG, MMP13, CCL2, IL2RA
37	actinomycin d32	6.7	IL2, IL1A, IL4, NOS2, TNF, IFNG
38	thymidine32 18	7.7	IL2, CXCR3, TNF, IFNG, CCL3, MMP13
39	hydrocortisone32 9 9	8.5	CCL3, IL4, IL2, IL1A, CDH5, CXCR3
40	serine32	6.4	CXCR3, TNFSF11, CCL5, IL1A, TNFRSF11B, MMP8
41	histamine32 18	7.4	TNF, CCL5, IL2, CDH5, CCL3, CCR5
42	retinoic acid32 42 18	8.3	MMP13, TNFRSF11B, MMP8, IL1A, MDK, CCL4
43	il 1032	6.3	CXCR3, TNF, IFNG, CCL5, CCL3, CCR5
44	nitric oxide32 9 18 9	8.9	CDH5, MMP13, CCL5, IFNG, TNF, TNFRSF11B
45	cycloheximide32	5.9	NOS2, TNFSF11, TNFRSF11B, TNF, IFNG, CCL5
46	indomethacin32 9 9	7.8	MMP13, NOS2, TNFSF11, TNFRSF11B, TNF, IFNG
47	cyclosporin a32 42	6.8	TNFSF11, TNFRSF11B, TNF, IFNG, CCL4, IL4
48	genistein32 9 18 9	8.7	IL2RA, CCL2, CCL5, IFNG, TNF, TNFRSF11B
49	rantes32	5.4	TNFRSF11B, TNF, IFNG, CCL5, CCL3, CCR5
50	dexamethasone32 42 34 9 9	9.1	CCL2, CCL4, IL4, IL2RA, IL2, IL1A

Cellular components related to periapical granuloma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:009897	8.2	IL4, CCR5, IFNG, TNF, CXCR3
2	extracellular region	GO:005576	5.9	CCL3, CCL5, IFNG, TNFRSF11B, TNFSF11, CCL2
3	extracellular space	GO:005615	5.5	MMP13, TNFSF11, TNFRSF11B, TNF, IFNG, CCL5

Biological processes related to periapical granuloma according to GeneDecks:

(show top 50)    (show all 58)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of homotypic cell-cell adhesion	GO:034112	10.4	TNFSF11, CCL5
2	astrocyte cell migration	GO:043615	10.3	CCL3, CCL2
3	signaling	GO:023052	10.3	CCL3, CCR5
4	innate immune response in mucosa	GO:002227	10.2	NOS2, IL4
5	positive regulation of natural killer cell chemotaxis	GO:2000503	10.2	CCL4, CCL3, CCL5
6	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	GO:014808	10.1	CCR5, CCL3
7	lymphocyte chemotaxis	GO:048247	10.1	CCL5, CCL3, CCL2
8	negative regulation by host of viral transcription	GO:043922	10.1	CCL5, CCL3, CCL4
9	cell activation	GO:001775	10.1	CCL3
10	positive regulation of calcium ion transport	GO:051928	10.1	CCL4, CCL3, CCL5
11	macrophage chemotaxis	GO:048246	10.1	CCL2, CCL3, CCL5
12	response to cholesterol	GO:070723	10.1	CCL5, CCL3, CCR5
13	cellular response to interleukin-1	GO:071347	10.1	CCL2, CCL3, CCL5
14	cellular response to tumor necrosis factor	GO:071356	10.0	CCL5, CCL3, CCL2
15	positive regulation of macrophage chemotaxis	GO:010759	10.0	CCL5, CCL2
16	monocyte chemotaxis	GO:002548	9.9	CCL2, CCL3, CCL5, TNFSF11
17	chemokine-mediated signaling pathway	GO:070098	9.9	CXCR3, CCL5, CCR5, CCL2
18	cellular response to interferon-gamma	GO:071346	9.9	CCL2, CCL3, CCL5, NOS2
19	response to toxin	GO:009636	9.7	CCL4, CCL3, CCL5
20	response to activity	GO:014823	9.7	TNF, CCL5, CCL2
21	positive regulation of killing of cells of other organism	GO:051712	9.7	NOS2, IFNG
22	positive regulation of fever generation	GO:031622	9.7	TNF, CCL5
23	calcium-mediated signaling	GO:019722	9.5	CXCR3, TNF, CCL3, CCR5
24	protein kinase B signaling cascade	GO:043491	9.5	TNF, CCL5, CCL3, CCL2
25	lipopolysaccharide-mediated signaling pathway	GO:031663	9.5	TNF, CCL5, CCL3, CCL2
26	positive regulation of protein kinase B signaling cascade	GO:051897	9.5	TNFSF11, TNF, CCL3
27	cellular response to organic cyclic compound	GO:071407	9.5	TNF, CCL5, CCL3, CCL2
28	neutrophil chemotaxis	GO:030593	9.5	IFNG, CCL3, CCL2
29	negative regulation of gene expression	GO:010629	9.4	CCL3, TNF, NOS2
30	positive regulation of vitamin D biosynthetic process	GO:060557	9.4	TNF, IFNG
31	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.4	TNF, IFNG
32	positive regulation of T cell proliferation	GO:042102	9.3	IFNG, CCL5, IL4
33	cell-cell signaling	GO:007267	9.3	CCL5, CCL3, CCR5, CCL4, IL2
34	extracellular matrix organization	GO:030198	9.3	MMP13, MMP8, TNF, TNFRSF11B
35	MAPK cascade	GO:000165	9.2	TNF, CCL5, CCL3, CCR5, CCL2
36	positive regulation of isotype switching to IgG isotypes	GO:048304	9.2	IL2, IL4, IFNG
37	cellular response to lipopolysaccharide	GO:071222	9.2	NOS2, IFNG, CCR5, CCL2
38	chemotaxis	GO:006935	9.1	IL4, CXCR3, CCL5, CCL3, CCR5, CCL2
39	positive regulation of chemokine biosynthetic process	GO:045080	9.1	TNF, IFNG, IL4
40	humoral immune response	GO:006959	9.1	CCL2, IFNG, TNF
41	cell surface receptor signaling pathway	GO:007166	9.0	IL2RA, CCL2, CCR5, IFNG
42	response to hypoxia	GO:001666	9.0	NOS2, TNF, CCL2, IL1A
43	positive regulation of osteoclast differentiation	GO:045672	9.0	TNFSF11, TNF, IFNG, CCL5
44	response to virus	GO:009615	8.8	TNF, IFNG, CCL5, CCL4
45	inflammatory response	GO:006954	8.5	TNF, CCL5, CCL3, CCR5, CCL2, CCL4
46	immune response	GO:006955	8.5	TNFSF11, CCR5, CCL4, IL4, IL2RA, IL2
47	anti-apoptosis	GO:006916	8.3	IL1A, IL2, CCL2, TNF
48	response to drug	GO:042493	8.2	TNFRSF11B, TNF, IFNG, CCL5, CCL2, IL4
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.7	TNFSF11, TNF, IFNG, IL4, IL2, IL1A
50	apoptotic process	GO:006915	7.7	CXCR3, TNFRSF11B, TNF, IFNG, IL2RA, IL1A

Molecular functions related to periapical granuloma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	phospholipase activator activity	GO:016004	10.0	CCL3, CCL5
2	CCR5 chemokine receptor binding	GO:031730	9.7	CCL5, CCL3, CCL4
3	CCR1 chemokine receptor binding	GO:031726	9.6	CCL4, CCL3, CCL5
4	chemokine activity	GO:008009	9.2	CCL5, CCL3, CCL2, CCL4
5	cytokine activity	GO:005125	6.8	IL1A, IL2, IL4, CCL4, IFNG, TNF