Aliases & Classifications for Periapical Granuloma

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 33MeSH, 55SNOMED-CT
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Periapical Granuloma, Aliases & Descriptions:

Name: Periapical Granuloma 9 43 60
 
Apical Granuloma 9


External Ids:

Disease Ontology9 DOID:4617
SNOMED-CT55 81407003, 196344002
MeSH33 D010484

Summaries for Periapical Granuloma

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MalaCards based summary: Periapical Granuloma, also known as apical granuloma, is related to leprosy and lepromatous leprosy. An important gene associated with Periapical Granuloma is MMP8 (matrix metallopeptidase 8 (neutrophil collagenase)), and among its related pathways are Matrix Metalloproteinases and IL2 signaling events mediated by PI3K. The compounds mcp 1 and gold sodium thiomalate have been mentioned in the context of this disorder. Affiliated tissues include endothelial, bone and colon, and related mouse phenotypes are no phenotypic analysis and vision/eye.

Related Diseases for Periapical Granuloma

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Diseases related to Periapical Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1leprosy30.9IL2
2lepromatous leprosy30.1IL2, IL4, IFNG
3farmer's lung10.6IL2RA
4bronchiolitis10.5CCL5, CCL3
5meningococcemia10.5CCL5
6chronic ulcer of skin10.4MMP8, MMP13
7proliferative glomerulonephritis10.4CCL2, CXCR3
8bacterial meningitis10.4CCL4, CCL3, MMP8
9intermediate uveitis10.4IL2RA, CCR5, CXCR3
10dengue disease10.4CCL4, CCL5, CCL3
11bronchiolitis obliterans10.4CXCR3, MMP8
12pulpitis10.4IL1A
13periodontal disease10.4TNFSF11, TNF
14systemic mastocytosis10.4CCL2, CCL5, CCL3
15vernal keratoconjunctivitis10.3IL4, CCL5, CXCR3
16osteolysis, familial expansile10.3TNFRSF11B, TNFSF11
17paget disease, juvenile10.3TNFRSF11B, TNFSF11
18central nervous system disease10.3CCR5, CCL2, CXCR3
19peripheral t-cell lymphoma10.3NOS2, IL2RA, CXCR3
20sjogren's syndrome10.3IL2RA, CCL3, CXCR3
21aggressive periodontitis10.3IL1A, MMP8
22pulmonary eosinophilia10.3IL4, CCL3
23contact dermatitis10.3IL1A, CXCR3
24pleurisy10.3IL2RA
25gastritis10.3NOS2, CCL5, CCL3
26hyperostosis, endosteal10.3TNFRSF11B, TNFSF11
27factor v leiden thrombophilia10.3CCL5, MMP8, MMP13, TNFSF11
28bone cancer10.3MMP13, TNFRSF11B, TNFSF11
29aortic valve disease 210.3CCR5, TNFRSF11B, TNFSF11
30extrinsic allergic alveolitis10.3IL1A, CCL3
31stroke, ischemic10.3CCL4, CCL3, MMP8, MMP13
32acute myocardial infarction10.2CDH5, CCL5, MMP8, TNFSF11
33idiopathic myopathy10.2IL1A, CCL2, CCL5
34middle ear cholesteatoma10.2IL1A, TNFSF11
35peritonitis10.2CCL2, MMP8, TNF
36marchiafava bignami disease10.2TNFRSF11B, TNFSF11
37glomerulonephritis10.2NOS2, CCL4, CCR5, CCL2
38aspergillosis10.2IFNG, CCL3
39aids dementia complex10.2NOS2, CCR5, TNF
40multiple myeloma10.2CCL3, TNFRSF11B, TNFSF11
41pulmonary fibrosis10.2CCL4, CCL2, CCL3, CXCR3, MMP13
42burkitt lymphoma10.2IL4, CCL3, CXCR3
43polymyositis10.2IL1A, CCR5, CCL3
44agammaglobulinemia10.2IL2, IL4
45osteoporosis10.2MMP8, MMP13, TNFRSF11B, TNFSF11
46periodontitis10.2IL1A, MMP8, TNFRSF11B
47secondary syphilis10.2CCL4, CCL3, TNFRSF11B, TNFSF11
48oral lichen planus10.2IL1A, CCR5, CCL5, CXCR3
49mycosis fungoides10.2IL2RA, IL2, CXCR3
50tuberculoid leprosy10.2IL2RA, IFNG

Graphical network of the top 20 diseases related to Periapical Granuloma:



Diseases related to periapical granuloma

Symptoms for Periapical Granuloma

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Drugs & Therapeutics for Periapical Granuloma

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Drug clinical trials:

Search ClinicalTrials for Periapical Granuloma

Search NIH Clinical Center for Periapical Granuloma

Genetic Tests for Periapical Granuloma

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Anatomical Context for Periapical Granuloma

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MalaCards organs/tissues related to Periapical Granuloma:

31
Endothelial, Bone, Colon, Monocytes, T cells, Neutrophil

Animal Models for Periapical Granuloma or affiliated genes

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MGI Mouse Phenotypes related to Periapical Granuloma:

35 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.4TNF, TNFSF11, CCR5, IFNG, IL4, IL2
2MP:00053918.3TNF, CCL2, CCR5, IFNG, IL4, NOS2
3MP:00053908.1TNF, TNFSF11, TNFRSF11B, MMP13, CCL2, IFNG
4MP:00053828.1TNF, TNFSF11, TNFRSF11B, CCL2, IFNG, IL4
5MP:00053798.1TNF, TNFSF11, IFNG, IL4, IL2, HPSE
6MP:00053888.0TNF, CXCR3, IFNG, IL4, IL2, NOS2
7MP:00020067.9TNF, MMP8, CXCR3, CCL2, CCR5, IFNG
8MP:00107717.9TNF, TNFSF11, MMP13, CCL2, IFNG, IL4
9MP:00053707.8TNF, CCL2, CCR5, IFNG, IL4, IL2
10MP:00053897.5TNF, TNFSF11, CCL2, CCR5, IFNG, IL4
11MP:00053817.3TNF, CCL3, CCL2, CCR5, IFNG, IL4
12MP:00036317.1CCL3, CCL2, CCR5, IFNG, IL4, NOS2
13MP:00053866.9TNF, CCL3, CCL2, CCR5, IFNG, IL2
14MP:00053786.4CCL3, MMP13, TNFRSF11B, TNFSF11, TNF, CCL2
15MP:00053856.4TNF, TNFRSF11B, MMP13, CXCR3, CCL2, CCR5
16MP:00107686.2CCL3, CXCR3, TNFRSF11B, TNFSF11, TNF, CCL2
17MP:00053766.0CCL3, CXCR3, MMP13, TNFSF11, TNF, CCL2
18MP:00053846.0CCL3, CXCR3, MMP13, TNFRSF11B, TNF, CCL2
19MP:00053875.0TNF, CDH5, MDK, NOS2, IL1A, IL2RA
20MP:00053974.8TNF, MDK, NOS2, HPSE, IL1A, IL2RA

Publications for Periapical Granuloma

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Articles related to Periapical Granuloma:

(show all 35)
idTitleAuthorsYear
1
Bioinformatics, Interaction Network Analysis, and Neural Networks to Characterize Gene Expression of Radicular Cyst and Periapical Granuloma. (25873079)
2015
2
Expression and immunohistochemical localization of leptin receptor in human periapical granuloma. (25081278)
2014
3
Heparanase expression in periapical granulomas and radicular cysts. (22020734)
2013
4
Oral pathology quiz #81. Case number 4. Dental (periapical) granuloma. (24597181)
2013
5
Periapical granuloma associated with extracted teeth. (22037071)
2011
6
Midkine expression in human periapical granulomas. (21787488)
2011
7
Distinct Th1, Th2 and Treg cytokines balance in chronic periapical granulomas and radicular cysts. (20102461)
2010
8
T-helper cell type 17/regulatory T-cell immunoregulatory balance in human radicular cysts and periapical granulomas. (20478453)
2010
9
High matrix metalloproteinase activity is a hallmark of periapical granulomas. (19720222)
2009
10
Antrochoanal polyp derived from periapical granuloma. (18701055)
2008
11
Differential patterns of receptor activator of nuclear factor kappa B ligand/osteoprotegerin expression in human periapical granulomas: possible association with progressive or stable nature of the lesions. (18634923)
2008
12
Involvement of inducible nitric oxide synthase and receptor for advanced glycation end products in periapical granulomas. (17258631)
2007
13
RANKL in human periapical granuloma: possible involvement in periapical bone destruction. (16700737)
2006
14
Co-production of vascular endothelial cadherin and inducible nitric oxide synthase by endothelial cells in periapical granuloma. (16507070)
2006
15
Oral diagnosis. Interradicular radiolucency of maxilla. Periapical granuloma. (16161239)
2005
16
Intraneural epithelial islands associated with a periapical granuloma: a cause for concern? (12796887)
2003
17
Hydrogen peroxide and superoxide anion production by polymorphonuclear neutrophils in patients with chronic periapical granuloma, before and after surgical treatment. (11355101)
2001
18
Evaluation of immunoglobulin G synthesizing plasma cells in periapical granuloma and cyst. (11441800)
2001
19
The presence of chemokine receptor (CCR5, CXCR3, CCR3)-positive cells and chemokine (MCP1, MIP-1alpha, MIP-1beta, IP-10)-positive cells in human periapical granulomas. (11683586)
2001
20
Differential in situ distribution of interleukin-8, monocyte chemoattractant protein-1 and Rantes in human chronic periapical granuloma. (11155167)
2000
21
Cytotoxic T lymphocytes versus streptococcal colonization in periapical granulomas. (10425947)
1999
22
Focal cemento-osseous dysplasia in the maxilla mimicking periapical granuloma. (10442950)
1999
23
Interferon-gamma-producing cells and inducible nitric oxide synthase-producing cells in periapical granulomas. (9563799)
1998
24
Immune cells in periapical granuloma: morphological and immunohistochemical characterization. (1895036)
1991
25
Quantitative analysis of the immunocompetent cells in periapical granuloma: correlation with the histological characteristics of the lesions. (1974913)
1990
26
The role of acute phase proteins in the pathogenesis of chronic periapical granuloma]. (1698164)
1990
27
Acute phase proteins in patients with chronic periapical granuloma before and after surgical treatment. (3268759)
1988
28
Endodontic treatment and immunopathology of periapical granuloma in an AIDS patient. (2977755)
1988
29
In situ characterization of cells in periapical granuloma by monoclonal antibodies. (3477750)
1987
30
Bacteriological status of periapical granuloma. (6597195)
1984
31
Macrophages isolated from periapical granuloma: a scanning electron microscopic study. (6592531)
1984
32
Isolation and characterization of inflammatory cells from the human periapical granuloma. (6983538)
1982
33
Quantitative analysis of cellular composition of human periapical granuloma. (6938631)
1981
34
Reddening of the upper central incisors associated with periapical granuloma in lepromatous leprosy. (1063039)
1976
35
A colony of actinomyces-like organisms in a periapical granuloma. (4161341)
1966

Variations for Periapical Granuloma

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Expression for genes affiliated with Periapical Granuloma

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Search GEO for disease gene expression data for Periapical Granuloma.

Pathways for genes affiliated with Periapical Granuloma

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Pathways related to Periapical Granuloma according to GeneCards Suite gene sharing:

(show top 50)    (show all 70)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6MMP8, MMP13, TNF
2
Show member pathways
IL2 signaling events mediated by STAT536
9.5IL2RA, IL2, IL4
3
Show member pathways
9.4TNFRSF11B, TNFSF11, TNF
49.4IL2RA, IL2, IFNG
59.3IFNG, IL4, IL2
69.2IFNG, CCL2, TNF
79.2TNF, CCL2, IFNG
89.1TNFSF11, CCL5, IL4, IL2, IL2RA
9
Show member pathways
IL27-mediated signaling events36
9.1IL2, IFNG, TNF
109.1IFNG, IL4, IL2, IL2RA
11
Show member pathways
Type III interferon signaling36
9.1IFNG, IL4, IL2, IL2RA
129.1TNF, IL4, IL2RA, IL1A
13
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
9.0TNF, IL4, IL2, IL2RA
14
Show member pathways
8.9IL1A, IFNG, CCR5, TNF
158.9CCL2, CCL3, TNF
168.9NOS2, IL1A, IFNG, TNF
17
Show member pathways
Immune response MIF in innate immunity response58
8.9TNF, IFNG, IL1A, NOS2
18
Show member pathways
Ras signaling in the CD4+ TCR pathway36
8.8IL2RA, IL2, IFNG, TNF
198.8NOS2, IL2, IFNG, TNF
20
Show member pathways
Immune response CD16 signaling in NK cells58
8.8TNF, IFNG, IL4, IL2
21
Show member pathways
8.8CCL2, IL4, IL2, IL2RA, MDK
22
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
8.7TNF, TNFSF11, TNFRSF11B, CCL5, CCL2, CCR5
23
Show member pathways
8.6CCL4, CCR5, CCL5, CCL3
24
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
8.6TNF, IFNG, IL4, IL1A, NOS2
25
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
8.6TNF, CCL2, IFNG, IL2, NOS2
26
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
8.6TNF, IFNG, IL4, IL2, IL2RA
278.6TNF, TNFSF11, TNFRSF11B, IFNG, IL1A
288.6TNF, TNFSF11, TNFRSF11B, IFNG, IL1A
298.4TNF, IFNG, IL4, IL2, IL1A
308.4TNF, IFNG, IL4, IL2, IL1A
31
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
8.2TNF, CCR5, IFNG, IL4, IL2, IL1A
32
Show member pathways
8.2TNF, IFNG, IL4, IL2, IL2RA, IL1A
33
Show member pathways
8.2TNF, IFNG, IL4, IL2, IL2RA, IL1A
34
Show member pathways
8.1CXCR3, CCL3, CCL5, CCL2, CCR5, CCL4
35
Show member pathways
8.1CXCR3, CCL3, CCL5, CCL2, CCR5, CCL4
36
Show member pathways
8.1CXCR3, CCL3, CCL5, CCL2, CCR5, CCL4
37
Show member pathways
7.9CCL3, CCL4, IFNG, IL1A, NOS2
38
Show member pathways
7.9TNF, CCR5, IFNG, IL4, IL2, IL1A
397.9TNF, CCL2, IFNG, IL4, IL2, IL1A
40
Show member pathways
7.7TNF, CCL5, CCL2, IFNG, IL4, IL2
417.6TNF, TNFSF11, CCL3, CCL5, CCL2, IFNG
42
Show member pathways
7.5MMP13, MMP8, CXCR3, CCL3, CCL5, CCL2
43
Show member pathways
7.4TNF, CCL3, CCL4, IFNG, IL2, IL2RA
44
Show member pathways
Immune response IL 12 induced IFN gamma production58
7.1CCL3, CCR5, CCL4, IFNG, IL4, IL2
45
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
6.9TNF, CCL3, CCL5, CCL2, CCL4, IFNG
46
Show member pathways
5.8TNF, CCL3, CCL5, CCL2, CCL4, IFNG
47
Show member pathways
5.6IL2, IL2RA, IL1A, MDK, IL4, CCL4
48
Show member pathways
5.6TNF, TNFSF11, CXCR3, CCL3, CCL5, CCL2
49
Show member pathways
5.3IL1A, IL2RA, TNF, TNFSF11, TNFRSF11B, CXCR3
50
Show member pathways
5.3TNF, TNFSF11, CXCR3, CCL3, CCL5, CCL2

Compounds for genes affiliated with Periapical Granuloma

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Compounds related to Periapical Granuloma according to GeneCards Suite gene sharing:

(show top 50)    (show all 246)
idCompoundScoreTop Affiliating Genes
1mcp 1438.6CCL3, CCL5, CCL2, CCL4, CXCR3
2gold sodium thiomalate438.5IFNG, IL1A, IL2RA, IL2, TNF
3infliximab43 49 1210.5TNFRSF11B, TNFSF11, CXCR3, TNF, IFNG, IL4
4polymyxin b438.4IL1A, IL4, IFNG, CCL2, TNFRSF11B, TNFSF11
5mdms438.2CCL3, CCL4, CCL2, CCL5, CCR5
6pentoxifylline43 129.2IL2, IL1A, IL4, IFNG, TNF, IL2RA
7larc438.2IL1A, CCL4, CCR5, CCL2, CCL5, CCL3
8thalidomide43 49 59 1211.2IL1A, IL2RA, IL2, IFNG, CCL5, TNFRSF11B
9ccl443 289.1CCL4, CCR5, CCL2, CCL5, CCL3, CXCR3
10ivig438.0TNF, CCR5, CCL4, IFNG, IL4, IL2RA
11toxin-1438.0IL2, CCL3, CCL4, TNF, CCL2
12ribavirin43 49 129.8IL4, IL2, IFNG, CCR5, CCL3, CXCR3
13calcitriol43 59 24 1210.7TNF, IL2RA, IL1A, IFNG, IL4, TNFSF11
14mip 1alpha437.7IL4, CCL4, CCR5, CCL2, CCL5, CCL3
15polyinosinic-polycytidylic acid437.7IL4, IL1A, IL2, IFNG, CCL3, NOS2
16pdtc437.7IL4, IFNG, CCL2, CCL5, CCL3, TNF
17neopterin437.6IL1A, IL2RA, IL2, IL4, CCL3, TNF
18ly294002437.6CCL5, TNF, TNFSF11, NOS2, IL4, CCL2
19herbimycin a43 598.6MMP13, TNF, CCL2, IFNG, NOS2, HPSE
20gm-csf43 288.6IL1A, IL2, IL4, IFNG, CCL2, CCL5
21heparan sulfate43 248.5CCL5, CCL4, MDK, CCL3, TNFRSF11B, TNFSF11
22groalpha437.5CCL5, CCL3, CXCR3, MMP13, TNF, CCL2
23triptolide437.3NOS2, IL2, IFNG, CCL4, CCL5, CCL3
24ccl343 288.2CCL3, CXCR3, TNF, IL1A, IFNG, CCL4
25endotoxin437.2NOS2, IL1A, IFNG, CCL4, CCL2, CCL5
26prednisolone43 28 129.2TNF, TNFRSF11B, CCL3, CCL4, IFNG, IL2
27simvastatin43 49 59 28 24 1212.1IL1A, IL4, IFNG, CCL4, CCR5, CCL2
28hydrocortisone43 2 59 1210.0CDH5, IL1A, IL2, IL4, IFNG, CCL5
29actinomycin d437.0CCL2, TNF, NOS2, MMP13, CCL3, CCR5
30ionomycin437.0IL1A, IL2RA, IL2, IL4, IFNG, CCL4
31thymidine43 248.0CXCR3, TNF, MMP13, CCL3, IFNG, IL2RA
32tacrolimus43 49 128.9IL2RA, IL2, IL4, IFNG, CCL4, CCL5
33tarc436.9CCR5, CCL2, CCL5, CCL3, CXCR3, TNF
34genistein43 28 59 2 24 1211.9MMP8, CCL5, CCL2, IFNG, IL2, IL2RA
35oxygen43 247.8CXCR3, CCL3, CCL4, HPSE, NOS2, CDH5
36cysteine436.8TNFSF11, CCL3, CCL5, TNFRSF11B, MMP13, CCL4
37heparin43 28 24 129.5TNFSF11, TNFRSF11B, MMP13, CXCR3, CCL3, CCL5
38histamine43 28 248.4IL4, IFNG, CCL4, CCR5, CCL2, CCL5
39sb 20358043 597.3CCL5, CCL3, MMP13, TNFRSF11B, TNFSF11, TNF
40il 10436.3CCL4, CCR5, CCL2, CCL5, CCL3, CXCR3
41retinoic acid43 247.1CCR5, CCL3, MMP8, MMP13, TNF, CCL5
42cyclosporin a43 28 598.0IL1A, TNF, IL2RA, IL2, IL4, IFNG
43indomethacin43 28 59 128.9CCL5, CCL3, MMP13, TNFRSF11B, TNFSF11, TNF
44serine435.9CCL3, IL2, CCL4, MMP8, HPSE, TNFSF11
45cycloheximide435.8TNFRSF11B, CCL4, IFNG, IL4, IL1A, IL2
46nitric oxide43 24 127.6TNF, TNFSF11, TNFRSF11B, MMP13, MMP8, CXCR3
47rantes435.5TNFSF11, TNF, IL2RA, IL2, IL4, IFNG
48dexamethasone43 49 28 128.2TNF, TNFSF11, TNFRSF11B, MMP13, CXCR3, CCL3
49pge2435.0NOS2, CCR5, CCL2, CCL5, CCL4, IFNG
50vegf434.6IL2RA, IL1A, HPSE, NOS2, CDH5, IL2

GO Terms for genes affiliated with Periapical Granuloma

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Cellular components related to Periapical Granuloma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.5CXCR3, CCR5, IFNG, IL4, IL2RA, TNF
2extracellular spaceGO:00056155.3IL2, IL4, IFNG, CCL4, CCL2, CCL5
3extracellular regionGO:00055764.9MDK, TNF, HPSE, IL1A, IL2, IFNG

Biological processes related to Periapical Granuloma according to GeneCards Suite gene sharing:

(show top 50)    (show all 78)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of homotypic cell-cell adhesionGO:003411210.3TNFSF11, CCL5
2regulation of T cell homeostatic proliferationGO:004601310.2IL2, IL2RA
3chemokine-mediated signaling pathwayGO:007009810.1CCL5, CCL2, CCR5
4positive regulation of killing of cells of other organismGO:005171210.1IFNG, NOS2
5innate immune response in mucosaGO:000222710.0IL4, NOS2
6positive regulation of activated T cell proliferationGO:00421049.9IL4, IL2, IL2RA
7positive regulation of macrophage chemotaxisGO:00107599.9CCL2, CCL5
8positive regulation of hair follicle developmentGO:00517989.9TNF, HPSE
9positive regulation of vitamin D biosynthetic processGO:00605579.9TNF, IFNG
10positive regulation of calcidiol 1-monooxygenase activityGO:00605599.8TNF, IFNG
11positive regulation of T cell proliferationGO:00421029.8CCL5, IFNG, IL4
12signalingGO:00230529.8CCL3, CCR5
13positive regulation of isotype switching to IgG isotypesGO:00483049.8IFNG, IL4, IL2
14extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.7IL4, IL2, IL1A
15cellular response to lipopolysaccharideGO:00712229.7CCL2, CCR5, IFNG, NOS2
16positive regulation of osteoclast differentiationGO:00456729.7IFNG, TNFSF11, TNF
17positive regulation of chemokine biosynthetic processGO:00450809.6TNF, IFNG, IL4
18T cell chemotaxisGO:00108189.6CXCR3, CCL3
19astrocyte cell migrationGO:00436159.6CCL3, CCL2
20release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:00148089.6CCL3, CCR5
21macrophage chemotaxisGO:00482469.6CCL2, CCL5, CCL3
22cellular response to interleukin-1GO:00713479.5CCL2, CCL5, CCL3
23humoral immune responseGO:00069599.5IFNG, CCL2, TNF
24cell surface receptor signaling pathwayGO:00071669.5IL2RA, IFNG, CCR5, CCL2, CXCR3
25cellular response to tumor necrosis factorGO:00713569.4CCL2, CCL5, CCL3
26response to cholesterolGO:00707239.4CCR5, CCL3
27monocyte chemotaxisGO:00025489.4CCL2, CCL5, CCL3, TNFSF11
28cytokine-mediated signaling pathwayGO:00192219.4TNFSF11, CCL2, IFNG, IL1A
29cellular response to interferon-gammaGO:00713469.4NOS2, CCL2, CCL5, CCL3
30neutrophil chemotaxisGO:00305939.3IFNG, CCL2, CCL3
31positive regulation of natural killer cell chemotaxisGO:020005039.3CCL4, CCL5, CCL3
32negative regulation by host of viral transcriptionGO:00439229.2CCL3, CCL5, CCL4
33positive regulation of calcium ion transportGO:00519289.2CCL4, CCL5, CCL3
34cell activationGO:00017759.1CCL3, TNF
35calcium-mediated signalingGO:00197229.1CCR5, CCL3, CXCR3, TNF
36lipopolysaccharide-mediated signaling pathwayGO:00316639.1TNF, CCL3, CCL5, CCL2
37protein kinase B signalingGO:00434919.1TNF, CCL3, CCL5, CCL2
38lymphocyte chemotaxisGO:00482479.1CCL2, CCL3
39cellular response to organic cyclic compoundGO:00714079.1TNF, CCL3, CCL5, CCL2
40response to virusGO:00096159.0TNF, CCL5, CCL4, IFNG
41positive regulation of protein kinase B signalingGO:00518979.0TNF, TNFSF11, CCL3, HPSE
42chemotaxisGO:00069358.9CXCR3, CCL3, CCL5, CCL2, CCR5, IL4
43response to toxic substanceGO:00096368.9CCL3, CCL5, CCL4
44MAPK cascadeGO:00001658.9TNF, CCL3, CCL5, CCL2, CCR5
45apoptotic processGO:00069158.7TNF, TNFRSF11B, CXCR3, IFNG, IL2RA, IL1A
46cell-cell signalingGO:00072678.6CCL3, CCL5, CCR5, CCL4, IL2
47immune responseGO:00069558.5TNFSF11, CCR5, CCL4, IL4, IL2, IL2RA
48response to drugGO:00424938.5TNF, TNFRSF11B, CCL2, IFNG, IL4, MDK
49positive regulation of transcription from RNA polymerase II promoterGO:00459448.4TNF, TNFSF11, CXCR3, IFNG, IL4, IL2
50inflammatory responseGO:00069547.4NOS2, TNF, CXCR3, CCL3, CCL5, CCL2

Molecular functions related to Periapical Granuloma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:000495010.1CCR5, CXCR3
2phospholipase activator activityGO:00160049.1CCL5, CCL3
3CCR5 chemokine receptor bindingGO:00317308.9CCL3, CCL5, CCL4
4CCR1 chemokine receptor bindingGO:00317268.8CCL3, CCL5, CCL4
5chemokine activityGO:00080098.5CCL3, CCL5, CCL2, CCL4
6cytokine activityGO:00051257.4IL1A, TNF, TNFSF11, TNFRSF11B, CCL4, IFNG

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3CDC
13ExPASy
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22GTR
23HGMD
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