MCID: PRP002
MIFTS: 29

Periapical Granuloma malady

Oral diseases category

Aliases & Classifications for Periapical Granuloma

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Sources:
10Disease Ontology, 47Novoseek, 65UMLS, 36MeSH, 59SNOMED-CT
See all sources

Aliases & Descriptions for Periapical Granuloma:

Name: Periapical Granuloma 10 47 65 36
 
Apical Granuloma 10


Classifications:



External Ids:

Disease Ontology10 DOID:4617
SNOMED-CT59 81407003, 196344002
MeSH36 D010484

Summaries for Periapical Granuloma

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MalaCards based summary: Periapical Granuloma, also known as apical granuloma, is related to endotheliitis and pericardial effusion. An important gene associated with Periapical Granuloma is TNFSF11 (Tumor Necrosis Factor (Ligand) Superfamily, Member 11), and among its related pathways are Development_Hedgehog and PTH signaling pathways in bone and cartilage development and NF-kappa B signaling pathway. Affiliated tissues include endothelial, neutrophil and t cells, and related mouse phenotypes are hematopoietic system and immune system.

Related Diseases for Periapical Granuloma

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Diseases related to Periapical Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
idRelated DiseaseScoreTop Affiliating Genes
1endotheliitis10.2
2pericardial effusion10.1MMP8, TNFSF11
3sebaceous adenoma10.1CXCL8, TNFSF11
4pharyngitis10.1CCL5, CXCL8
5scotoma10.1CCL5, CXCL8
6mycobacterium abscessus10.1CCL5, CXCL8
7dawson disease10.0CCL5, CXCL8
8visceral heterotaxy10.0CCL5, CXCL8
9microphthalmia10.0CCL5, CXCL8
10chronic congestive splenomegaly10.0CCL5, CXCL8
11preterm premature rupture of the membranes10.0CXCL8, MMP8
12benign eccrine breast spiradenoma10.0CCL5, CXCL8
13otitis externa10.0CXCL8, TNFSF11
14pyloric stenosis10.0CP, CXCL8
15glioblastoma multiforme10.0CXCL8, MMP8
16pneumonia10.0CP, CXCL8
17bronchopulmonary dysplasia10.0CXCL8, MMP8
18balanitis10.0CXCL8, MMP8
19keratosis10.0CCL5, CXCL8
20mixed cerebral palsy10.0CXCL8, MMP8
21hypoglycemic coma9.9CCL5, CXCL8
22tooth disease9.9MMP13, MMP8
23plummer's disease9.9CCL5, CXCL8, TNFSF11
24tuberculosis9.9CCL5, CXCL8
25interstitial nephritis9.9CCL5, CXCL8
26periodontitis9.9CXCL8, MMP8, TNFSF11
27bronchial neoplasm9.9CCL5, CXCL8
28mature b-cell neoplasm9.9CCL5, CP, CXCL8
29synovium cancer9.8CXCL8, MMP13, TNFSF11
30osteochondritis dissecans9.8CXCL8, MMP13, TNFSF11
31asphyxia neonatorum9.7CXCL8, MMP13, TNFSF11
32syndromic x-linked intellectual disability9.7MMP13, MMP8
33rheumatoid arthritis9.6CCL5, CXCL8, MMP13, TNFSF11
34periostitis9.6CXCL8, MMP13, MMP8, TNFSF11
35angiokeratoma circumscriptum9.0CCL5, CDH5, CP, CXCL8, MMP13, MMP8

Graphical network of the top 20 diseases related to Periapical Granuloma:



Diseases related to periapical granuloma

Symptoms for Periapical Granuloma

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Drugs & Therapeutics for Periapical Granuloma

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Interventional clinical trials:

idNameStatusNCT IDPhase
1RCT: Effectiveness of a Microscope During Dental Root Apical SurgeryRecruitingNCT01759069

Search NIH Clinical Center for Periapical Granuloma


Cochrane evidence based reviews: Periapical Granuloma

Genetic Tests for Periapical Granuloma

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Anatomical Context for Periapical Granuloma

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MalaCards organs/tissues related to Periapical Granuloma:

33
Endothelial, Neutrophil, T cells, Monocytes, Colon, Bone

Animal Models for Periapical Granuloma or affiliated genes

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MGI Mouse Phenotypes related to Periapical Granuloma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.9CCL5, CDH5, CP, CXCL8, TNFSF11
2MP:00053877.0CCL5, CDH5, CP, CXCL8, MMP8, TNFSF11

Publications for Periapical Granuloma

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Articles related to Periapical Granuloma:

(show all 34)
idTitleAuthorsYear
1
Bioinformatics, Interaction Network Analysis, and Neural Networks to Characterize Gene Expression of Radicular Cyst and Periapical Granuloma. (25873079)
2015
2
Expression and immunohistochemical localization of leptin receptor in human periapical granuloma. (25081278)
2014
3
Heparanase expression in periapical granulomas and radicular cysts. (22020734)
2013
4
Oral pathology quiz #81. Case number 4. Dental (periapical) granuloma. (24597181)
2013
5
Periapical granuloma associated with extracted teeth. (22037071)
2011
6
Midkine expression in human periapical granulomas. (21787488)
2011
7
Distinct Th1, Th2 and Treg cytokines balance in chronic periapical granulomas and radicular cysts. (20102461)
2010
8
T-helper cell type 17/regulatory T-cell immunoregulatory balance in human radicular cysts and periapical granulomas. (20478453)
2010
9
High matrix metalloproteinase activity is a hallmark of periapical granulomas. (19720222)
2009
10
Antrochoanal polyp derived from periapical granuloma. (18701055)
2008
11
Differential patterns of receptor activator of nuclear factor kappa B ligand/osteoprotegerin expression in human periapical granulomas: possible association with progressive or stable nature of the lesions. (18634923)
2008
12
Involvement of inducible nitric oxide synthase and receptor for advanced glycation end products in periapical granulomas. (17258631)
2007
13
RANKL in human periapical granuloma: possible involvement in periapical bone destruction. (16700737)
2006
14
Co-production of vascular endothelial cadherin and inducible nitric oxide synthase by endothelial cells in periapical granuloma. (16507070)
2006
15
Oral diagnosis. Interradicular radiolucency of maxilla. Periapical granuloma. (16161239)
2005
16
Intraneural epithelial islands associated with a periapical granuloma: a cause for concern? (12796887)
2003
17
Hydrogen peroxide and superoxide anion production by polymorphonuclear neutrophils in patients with chronic periapical granuloma, before and after surgical treatment. (11355101)
2001
18
Evaluation of immunoglobulin G synthesizing plasma cells in periapical granuloma and cyst. (11441800)
2001
19
The presence of chemokine receptor (CCR5, CXCR3, CCR3)-positive cells and chemokine (MCP1, MIP-1alpha, MIP-1beta, IP-10)-positive cells in human periapical granulomas. (11683586)
2001
20
Differential in situ distribution of interleukin-8, monocyte chemoattractant protein-1 and Rantes in human chronic periapical granuloma. (11155167)
2000
21
Cytotoxic T lymphocytes versus streptococcal colonization in periapical granulomas. (10425947)
1999
22
Focal cemento-osseous dysplasia in the maxilla mimicking periapical granuloma. (10442950)
1999
23
Interferon-gamma-producing cells and inducible nitric oxide synthase-producing cells in periapical granulomas. (9563799)
1998
24
Immune cells in periapical granuloma: morphological and immunohistochemical characterization. (1895036)
1991
25
Quantitative analysis of the immunocompetent cells in periapical granuloma: correlation with the histological characteristics of the lesions. (1974913)
1990
26
The role of acute phase proteins in the pathogenesis of chronic periapical granuloma]. (1698164)
1990
27
Acute phase proteins in patients with chronic periapical granuloma before and after surgical treatment. (3268759)
1988
28
Endodontic treatment and immunopathology of periapical granuloma in an AIDS patient. (2977755)
1988
29
In situ characterization of cells in periapical granuloma by monoclonal antibodies. (3477750)
1987
30
Bacteriological status of periapical granuloma. (6597195)
1984
31
Macrophages isolated from periapical granuloma: a scanning electron microscopic study. (6592531)
1984
32
Isolation and characterization of inflammatory cells from the human periapical granuloma. (6983538)
1982
33
Quantitative analysis of cellular composition of human periapical granuloma. (6938631)
1981
34
A colony of actinomyces-like organisms in a periapical granuloma. (4161341)
1966

Variations for Periapical Granuloma

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Expression for genes affiliated with Periapical Granuloma

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Search GEO for disease gene expression data for Periapical Granuloma.

Pathways for genes affiliated with Periapical Granuloma

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GO Terms for genes affiliated with Periapical Granuloma

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Cellular components related to Periapical Granuloma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.2CCL5, CP, CXCL8, MMP13, MMP8, TNFSF11
2extracellular regionGO:00055766.9CCL5, CP, CXCL8, MMP13, MMP8, TNFSF11

Biological processes related to Periapical Granuloma according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of homotypic cell-cell adhesionGO:003411210.3CCL5, TNFSF11
2monocyte chemotaxisGO:000254810.2CCL5, TNFSF11
3positive regulation of osteoclast differentiationGO:004567210.1CCL5, TNFSF11
4negative regulation of G-protein coupled receptor protein signaling pathwayGO:00457449.9CCL5, CXCL8
5cellular response to interleukin-1GO:00713479.9CCL5, CXCL8
6positive regulation of phosphorylationGO:00423279.8CCL5, TNFSF11
7cellular response to tumor necrosis factorGO:00713569.8CCL5, CXCL8
8neutrophil chemotaxisGO:00305939.8CCL5, CXCL8
9neutrophil activationGO:00421199.8CCL5, CXCL8
10chemokine-mediated signaling pathwayGO:00700989.8CCL5, CXCL8
11receptor internalizationGO:00316239.7CXCL8, MMP13
12response to estrogenGO:00436279.7CCL5, MMP13
13cellular response to fibroblast growth factor stimulusGO:00443449.6CCL5, CXCL8
14ossificationGO:00015039.6MMP13, TNFSF11
15immune responseGO:00069559.4CCL5, CXCL8, TNFSF11
16collagen catabolic processGO:00305749.3MMP13, MMP8

Molecular functions related to Periapical Granuloma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00080099.5CCL5, CXCL8

Sources for Periapical Granuloma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet