MCID: PRP002
MIFTS: 31

Periapical Granuloma malady

Categories: Oral diseases

Aliases & Classifications for Periapical Granuloma

Aliases & Descriptions for Periapical Granuloma:

Name: Periapical Granuloma 12 52 42 14 69
Apical Granuloma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4617
MeSH 42 D010484
SNOMED-CT 64 196344002 81407003
UMLS 69 C0031029

Summaries for Periapical Granuloma

MalaCards based summary : Periapical Granuloma, also known as apical granuloma, is related to breast intracanalicular fibroadenoma and hidradenitis suppurativa. An important gene associated with Periapical Granuloma is TNFSF11 (TNF Superfamily Member 11), and among its related pathways/superpathways are Integrin Pathway and Insulin receptor recycling. The drugs Mepivacaine and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include endothelial, t cells and neutrophil, and related phenotype is Decreased shRNA abundance (Z-score < -2).

Related Diseases for Periapical Granuloma

Diseases related to Periapical Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
id Related Disease Score Top Affiliating Genes
1 breast intracanalicular fibroadenoma 10.1 CXCL8 TNFSF11
2 hidradenitis suppurativa 10.1 CCL5 CXCL8
3 infectious anterior uveitis 10.1 CCL5 CXCL8
4 erb-duchenne and dejerine-klumpke palsies 10.1 CCL5 CXCL8
5 mixed mineral dust pneumoconiosis 10.1 CCL5 CXCL8
6 patellar tendinitis 10.1 CCL5 CXCL8
7 hyperimmunoglobulin syndrome 10.1 CCL5 CXCL8
8 breast apocrine carcinoma in situ 10.1 CCL5 CXCL8
9 vitreoretinopathy, neovascular inflammatory 10.0 CXCL8 MMP8
10 choroiditis 10.0 CP CXCL8
11 classic type lipoma 10.0 CXCL8 TNFSF11
12 vascular dementia 10.0 MMP8 TNFSF11
13 burns 10.0 CXCL8 MMP8
14 infancy electroclinical syndrome 10.0 CXCL8 MMP8
15 stenosis of lacrimal sac 10.0 CXCL8 MMP8
16 baritosis 10.0 CP CXCL8
17 unilateral hypoactive labyrinth 10.0 CXCL8 MMP8
18 mast-cell leukemia 10.0 CCL5 CXCL8
19 pityriasis rosea 10.0 MMP13 MMP8
20 fasciitis 9.9 CXCL8 MMP8
21 autosomal recessive type iv ehlers-danlos syndrome 9.9 CXCL8 MMP8 TNFSF11
22 pulmonary tuberculosis 9.9 CCL5 CXCL8
23 fungal gastritis 9.9 CXCL8 MMP8 TNFSF11
24 histiocytosis 9.9 CXCL8 MMP8 TNFSF11
25 paragonimiasis 9.9 CCL5 CP CXCL8
26 spontaneous ocular nystagmus 9.8 CCL5 CXCL8
27 synovium cancer 9.8 CXCL8 MMP13 TNFSF11
28 bone angioendothelial sarcoma 9.8 CXCL8 MMP13 TNFSF11
29 osteonecrosis 9.8 CXCL8 MMP13 TNFSF11
30 autistic disorder 9.8 CXCL8 MMP13 TNFSF11
31 leprosy 9.7
32 lepromatous leprosy 9.7
33 endotheliitis 9.7
34 rheumatoid arthritis 9.6 CCL5 CXCL8 MMP13 TNFSF11
35 intratubular embryonal carcinoma 9.6 CXCL8 MMP13 MMP8 TNFSF11
36 nasal cavity inverting papilloma 9.1 CCL5 CDH5 CP CXCL8 MMP13 MMP8

Graphical network of the top 20 diseases related to Periapical Granuloma:



Diseases related to Periapical Granuloma

Symptoms & Phenotypes for Periapical Granuloma

GenomeRNAi Phenotypes related to Periapical Granuloma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.92 CCL5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.92 MMP13
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.92 MMP8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.92 TNFSF11
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.92 TNFSF11 CDH5 MMP8
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.92 CCL5
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-175 9.92 TNFSF11 CDH5
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.92 TNFSF11 CDH5
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.92 MMP8
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.92 MMP8
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.92 CCL5
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.92 MMP8
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.92 CDH5
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.92 CDH5
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.92 CCL5
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.92 MMP13
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.92 CDH5
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.92 TNFSF11 CCL5 MMP13

Drugs & Therapeutics for Periapical Granuloma

Drugs for Periapical Granuloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mepivacaine Approved, Vet_approved 96-88-8 4062
2 Anesthetics
3 Anesthetics, Local
4 Central Nervous System Depressants

Interventional clinical trials:


id Name Status NCT ID Phase
1 RCT: Effectiveness of a Microscope During Dental Root Apical Surgery Unknown status NCT01759069
2 Evaluation of Anesthetic Efficacy in Extraction on Mandibular Molars Not yet recruiting NCT03106168

Search NIH Clinical Center for Periapical Granuloma

Cochrane evidence based reviews: periapical granuloma

Genetic Tests for Periapical Granuloma

Anatomical Context for Periapical Granuloma

MalaCards organs/tissues related to Periapical Granuloma:

39
Endothelial, T Cells, Neutrophil, Monocytes, Bone, Colon

Publications for Periapical Granuloma

Articles related to Periapical Granuloma:

(show all 36)
id Title Authors Year
1
Expression of interleukin-33 and its receptor ST2 in periapical granulomas and radicular cysts. ( 25677987 )
2016
2
Bioinformatics, Interaction Network Analysis, and Neural Networks to Characterize Gene Expression of Radicular Cyst and Periapical Granuloma. ( 25873079 )
2015
3
Expression and immunohistochemical localization of leptin receptor in human periapical granuloma. ( 25081278 )
2014
4
Heparanase expression in periapical granulomas and radicular cysts. ( 22020734 )
2013
5
Oral pathology quiz #81. Case number 4. Dental (periapical) granuloma. ( 24597181 )
2013
6
Periapical granuloma associated with extracted teeth. ( 22037071 )
2011
7
Midkine expression in human periapical granulomas. ( 21787488 )
2011
8
T-helper cell type 17/regulatory T-cell immunoregulatory balance in human radicular cysts and periapical granulomas. ( 20478453 )
2010
9
Distinct Th1, Th2 and Treg cytokines balance in chronic periapical granulomas and radicular cysts. ( 20102461 )
2010
10
High matrix metalloproteinase activity is a hallmark of periapical granulomas. ( 19720222 )
2009
11
Differential patterns of receptor activator of nuclear factor kappa B ligand/osteoprotegerin expression in human periapical granulomas: possible association with progressive or stable nature of the lesions. ( 18634923 )
2008
12
Antrochoanal polyp derived from periapical granuloma. ( 18701055 )
2008
13
Involvement of inducible nitric oxide synthase and receptor for advanced glycation end products in periapical granulomas. ( 17258631 )
2007
14
RANKL in human periapical granuloma: possible involvement in periapical bone destruction. ( 16700737 )
2006
15
Co-production of vascular endothelial cadherin and inducible nitric oxide synthase by endothelial cells in periapical granuloma. ( 16507070 )
2006
16
Oral diagnosis. Interradicular radiolucency of maxilla. Periapical granuloma. ( 16161239 )
2005
17
Intraneural epithelial islands associated with a periapical granuloma: a cause for concern? ( 12796887 )
2003
18
Evaluation of immunoglobulin G synthesizing plasma cells in periapical granuloma and cyst. ( 11441800 )
2001
19
The presence of chemokine receptor (CCR5, CXCR3, CCR3)-positive cells and chemokine (MCP1, MIP-1alpha, MIP-1beta, IP-10)-positive cells in human periapical granulomas. ( 11683586 )
2001
20
Hydrogen peroxide and superoxide anion production by polymorphonuclear neutrophils in patients with chronic periapical granuloma, before and after surgical treatment. ( 11355101 )
2001
21
Differential in situ distribution of interleukin-8, monocyte chemoattractant protein-1 and Rantes in human chronic periapical granuloma. ( 11155167 )
2000
22
Cytotoxic T lymphocytes versus streptococcal colonization in periapical granulomas. ( 10425947 )
1999
23
Focal cemento-osseous dysplasia in the maxilla mimicking periapical granuloma. ( 10442950 )
1999
24
Interferon-gamma-producing cells and inducible nitric oxide synthase-producing cells in periapical granulomas. ( 9563799 )
1998
25
Immune cells in periapical granuloma: morphological and immunohistochemical characterization. ( 1895036 )
1991
26
Quantitative analysis of the immunocompetent cells in periapical granuloma: correlation with the histological characteristics of the lesions. ( 1974913 )
1990
27
[The role of acute phase proteins in the pathogenesis of chronic periapical granuloma]. ( 1698164 )
1990
28
Acute phase proteins in patients with chronic periapical granuloma before and after surgical treatment. ( 3268759 )
1988
29
Endodontic treatment and immunopathology of periapical granuloma in an AIDS patient. ( 2977755 )
1988
30
In situ characterization of cells in periapical granuloma by monoclonal antibodies. ( 3477750 )
1987
31
Bacteriological status of periapical granuloma. ( 6597195 )
1984
32
Macrophages isolated from periapical granuloma: a scanning electron microscopic study. ( 6592531 )
1984
33
Isolation and characterization of inflammatory cells from the human periapical granuloma. ( 6983538 )
1982
34
Quantitative analysis of cellular composition of human periapical granuloma. ( 6938631 )
1981
35
Reddening of the upper central incisors associated with periapical granuloma in lepromatous leprosy. ( 1063039 )
1976
36
A colony of actinomyces-like organisms in a periapical granuloma. ( 4161341 )
1966

Variations for Periapical Granuloma

Expression for Periapical Granuloma

Search GEO for disease gene expression data for Periapical Granuloma.

Pathways for Periapical Granuloma

GO Terms for Periapical Granuloma

Cellular components related to Periapical Granuloma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CCL5 CP CXCL8 MMP13 MMP8 TNFSF11
2 extracellular space GO:0005615 9.1 CCL5 CP CXCL8 MMP13 MMP8 TNFSF11

Biological processes related to Periapical Granuloma according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.7 CCL5 CXCL8 TNFSF11
2 extracellular matrix disassembly GO:0022617 9.51 MMP13 MMP8
3 cellular response to interleukin-1 GO:0071347 9.49 CCL5 CXCL8
4 chemokine-mediated signaling pathway GO:0070098 9.48 CCL5 CXCL8
5 neutrophil chemotaxis GO:0030593 9.46 CCL5 CXCL8
6 collagen catabolic process GO:0030574 9.43 MMP13 MMP8
7 calcium-mediated signaling GO:0019722 9.4 CXCL8 TNFSF11
8 monocyte chemotaxis GO:0002548 9.37 CCL5 TNFSF11
9 cellular response to fibroblast growth factor stimulus GO:0044344 9.32 CCL5 CXCL8
10 positive regulation of phosphorylation GO:0042327 9.26 CCL5 TNFSF11
11 negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 9.16 CCL5 CXCL8
12 neutrophil activation GO:0042119 8.96 CCL5 CXCL8
13 positive regulation of homotypic cell-cell adhesion GO:0034112 8.62 CCL5 TNFSF11

Molecular functions related to Periapical Granuloma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 8.96 CCL5 CXCL8
2 cytokine activity GO:0005125 8.8 CCL5 CXCL8 TNFSF11

Sources for Periapical Granuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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