MCID: PRC012
MIFTS: 47

Pericardial Effusion malady

Cardiovascular category

Summaries for Pericardial Effusion

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Pericardial effusion (\"fluid around the heart\") is an abnormal accumulation of fluid in the... more...

MalaCards: Pericardial Effusion is related to constrictive pericarditis and arthritis. An important gene associated with Pericardial Effusion is ADA (adenosine deaminase), and among its related pathways are Integrins in angiogenesis and Development Ligand-dependent activation of the ESR1/AP-1 pathway. The compounds estrogen and tamoxifen have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and skeleton.

Disease Ontology:8 A heart disease that is characterized by an abnormal accumulation of fluid in the pericardial cavity.

Aliases & Classifications for Pericardial Effusion

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

pericardial effusion 8 10 45 61


External Ids:

Disease Ontology8 DOID:118
MeSH35 D010490
SNOMED-CT57 70370001, 373945007
NCIt40 C3319
ICD1025 I31.3

Related Diseases for Pericardial Effusion

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pericardial Effusion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 382)
idRelated DiseaseScoreTop Affiliating Genes
1constrictive pericarditis30.7ADA, NPPB
2arthritis30.7ALB, FGF2, TNFRSF11B
3angiosarcoma30.6MUC1, VIM
4adenocarcinoma30.6ADA, CEACAM3, MUC1, MUC16, HIF1A, VEGFA
5ventricular septal defect30.5TNNI3
6acute leukemia30.4TOP1, TNFSF10
7thymoma30.3CEACAM3
8acute pancreatitis30.3PSG2
9systemic scleroderma30.3TOP1
10cardiac rupture30.3CHKB
11acute myocardial infarction30.3CHKB, PIK3C2A, NPPB, TNNI3
12meigs syndrome30.1MUC16
13legionnaires' disease30.1PIK3C2A
14bronchogenic cyst30.1MUC16
15anorexia nervosa30.1TNFRSF11B
16polymyositis30.1CHKB, PIK3C2A
17duchenne muscular dystrophy30.0CHKB, PIK3C2A, TNNI3
18cystic fibrosis30.0ALB, TNFRSF11B
19stroke, ischemic30.0ALB, S100B
20atrioventricular block30.0PIK3C2A, NPPB
21synovial sarcoma30.0MUC1, S100B, VIM
22adenoid cystic carcinoma30.0CEACAM3, MUC1, S100B, VIM
23atherosclerosis30.0ALB, FGF2, TNFRSF11B, TNFSF10
24benign mesothelioma30.0ADA, CEACAM3, MUC1, MUC16, PSG2, TNFSF10
25cardiac tamponade10.9
26erdheim-chester disease10.4
27systemic lupus erythematosus10.4
28endomyocardial fibrosis10.4
29pericardial mesothelioma10.4
30pericardial tuberculosis10.4
31n syndrome10.4
32primary effusion lymphoma10.4
33cardiac diverticulum10.4
34mixed connective tissue disease10.3
35myxedema10.3
36hemopericardium10.3
37tuberculosis10.3
38hemangioendothelioma10.3
39mass syndrome10.3
40dysphagia10.3
41bronchiolitis10.2
42lymphangioleiomyomatosis10.2
43coronary aneurysm10.2
44hypoparathyroidism10.2
45yellow nail syndrome10.2
46diabetes insipidus10.2
47melioidosis10.2
48polymyalgia rheumatica10.2
49lymphosarcoma10.2
50churg-strauss syndrome10.2

Graphical network of the top 20 diseases related to Pericardial Effusion:



Diseases related to pericardial effusion

Clinical Features for Pericardial Effusion

Drugs & Therapeutics for Pericardial Effusion

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pericardial Effusion

Drug clinical trials:

Search ClinicalTrials for Pericardial Effusion

Search NIH Clinical Center for Pericardial Effusion

Search CenterWatch for Pericardial Effusion

Genetic Tests for Pericardial Effusion

Anatomical Context for Pericardial Effusion

Animal Models for Pericardial Effusion or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Pericardial Effusion

Sources:
51PubMed
See all sources

Articles related to Pericardial Effusion:

(show top 50)    (show all 567)
idTitleAuthorsYear
1
Etiology and characteristics of large symptomatic pericardial effusion in a community hospital in the contemporary era. (24368855)
2014
2
Malignant pericardial effusion: still a long way to Ithaca? (23615155)
2013
3
Chronic pericardial effusion secondary to a influenza virus A (H1N1)/2009 infection. (23666306)
2013
4
The efficiency of surgical subxiphoid pericardial drainage and percutaneous pericardial drainage in pericardial effusions associated with cardiac tamponade. (23618573)
2013
5
Thoracic radiographic findings for dogs with cardiac tamponade attributable to pericardial effusion. (23822080)
2013
6
Percutaneous balloon pericardiotomy as the initial and definitive treatment for malignant pericardial effusion. (23266066)
2013
7
Cardiac juvenile xanthogranuloma in an infant presenting with pericardial effusion. (22691125)
2013
8
The potential additional diagnostic value of assessing for pericardial effusion on cardiac magnetic resonance imaging in patients with suspected myocarditis. (24378485)
2013
9
Infantile cardiac haemangioma with large pericardial effusion diagnosed during acute bronchiolitis episode. (22250834)
2012
10
Comparison of surgical pericardial drainage with percutaneous catheter drainage for pericardial effusion. (23117314)
2012
11
CT based volume measurement and estimation in cases of pericardial effusion. (22390997)
2012
12
Unusual cause of pericardial effusion. (22949120)
2012
13
Anesthesia for children with pericardial effusion: a case series. (22672437)
2012
14
Sudden cardiac arrest caused by tuberculous pericarditis with hemorrhagic pericardial effusion. (23154733)
2012
15
Fever, dyspnea and chest pain with pericardial effusion. Primary cardiac angiosarcoma. (22766238)
2012
16
Symptomatic pericardial effusion in Hodgkin's lymphoma: a rare occurrence. Case report and review of the literature. (22678004)
2012
17
Percutaneous balloon pericardiotomy for recurrent malignant pericardial effusion. (22088990)
2011
18
A rare case of situs inversus with dextrocardia, lutembacher syndrome, and pericardial effusion. (22567197)
2011
19
Pericardial effusion and pneumothorax after breast augmentation. (19217239)
2011
20
Pleural and pericardial effusions: rare presentations of brucellosis, Iran. (21713754)
2011
21
Is pericardiocentesis needed for preventing hypoplastic lung in case with massive pericardial effusion? (23737150)
2011
22
The importance of echocardiographic evaluation of pericardial effusion associated with mitral valve pseudoprolapse in patients with chronic renal failure. (21912031)
2011
23
Case report: Percutaneous balloon pericardiotomy using Inoue balloon for patients with massive pericardial effusion. (18778860)
2010
24
Percutaneous balloon pericardiotomy in a patient with end stage renal disease with recurrent pericardial effusion & pericardial tamponade. (21180046)
2010
25
CT findings in patients with pericardial effusion: differentiation of malignant and benign disease. (20489067)
2010
26
Effectiveness and prognosis of initial pericardiocentesis in the primary management of malignant pericardial effusion. (20504889)
2010
27
Computed tomography-guided pericardiocentesis: utility in the management of malignant pericardial effusion. (20223409)
2010
28
Transthoracic echocardiographic view of aortic dissection, massive pericardial effusion and severe left ventricular hypertrophy in a young patient with uncontrolled hypertension. (20380667)
2010
29
Diagnosis of Coxiella burnetii pericarditis by using a systematic prescription kit in cases of pericardial effusion: an 8-year experience. (19548995)
2009
30
Pericardial effusion presenting with anuric acute renal failure and hepatocellular damage. (19140198)
2009
31
Clinical and cytological correlations in pericardial effusions with cardiac tamponade. (19434319)
2009
32
Purulent pericardial effusion in a 14-year-old girl. (19953691)
2009
33
Primary mediastinal synovial sarcoma with transdiaphragmatic extension presenting as a pericardial effusion. (19224065)
2009
34
Echocardiographic and clinicopathologic characterization of pericardial effusion in dogs: 107 cases (1985-2006). (20001781)
2009
35
Pericardial effusion on Tc-99m SPECT perfusion study. (18984444)
2008
36
Large pericardial effusion due to peritoneopericardial fistula. (17716757)
2008
37
Clozapine-induced pericardial effusion. (18626276)
2008
38
Epicardial lipoma mimicking pericardial effusion. (17435071)
2007
39
Isolated pleural and pericardial effusion in a patient with ankylosing spondylitis. (16781130)
2007
40
Canine pericardial effusion: pathophysiology and cause. (17727046)
2007
41
Does this patient with a pericardial effusion have cardiac tamponade? (17456823)
2007
42
Breast implant mimicking pericardial effusion in a cancer patient undergoing gated heart pool radionuclide study. (17937644)
2007
43
Mediastinal pseudocyst with pericardial effusion and dysphagia treated by endoscopic drainage. (16832138)
2006
44
Pericardial effusion with vesiculobullous lesions in a young female. Bullous systemic lupus erythematosus (bullous SLE). (16707837)
2006
45
Images in cardiology: Transient pericardial effusion after cardiac surgery: often unrecognised. (16103562)
2005
46
The anteroposterior pericardial sac diameter measured by echocardiography correlates with the volume of pericardial effusion and with effort dyspnea. (16153556)
2005
47
Video-assisted thoracoscopic pericardial fenestration for tuberculous pericardial effusion. (14997974)
2004
48
Endomyocardial fibrosis presenting as chronic pericardial effusion. (5678613)
1968
49
Streptobacillary rat-bite fever with massive pericardial effusion. (5340333)
1967
50
Addendum to "Hodgkin's granuloma with pericardial effusion". (14877759)
1951

Genetic Variations for Pericardial Effusion

Expression for genes affiliated with Pericardial Effusion

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pericardial Effusion

Search GEO for disease gene expression data for Pericardial Effusion.

Pathways for genes affiliated with Pericardial Effusion

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 50PharmGKB, 56SinoBiological
See all sources

Pathways related to Pericardial Effusion according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0VEGFA
2
Development Ligand-dependent activation of the ESR1/AP-1 pathway
Hide members
9.5VEGFA, HIF1A, ADA
39.4FGF2, HIF1A, VEGFA
4
Hide members
9.1FGF2, VEGFA, PIK3C2A

Compounds for genes affiliated with Pericardial Effusion

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Pericardial Effusion according to GeneCards/GeneDecks:

(show top 50)    (show all 178)
idCompoundScoreTop Affiliating Genes
1estrogen4510.2CHKB, NPPB
2tamoxifen45 50 29 1112.9CEACAM3, CHKB, TNFSF10
3mucicarmine459.4VIM, MUC1, CEACAM3, S100B
4glycogen45 2410.1NPPB, PSG2, PIK3C2A, CHKB
5dihydrotestosterone45 29 11 2412.0MUC1, HIF1A, FGF2, TNFRSF11B, VIM, CHKB
6bortezomib45 1110.0HIF1A, TNFSF10, VEGFA, TOP1, TNFRSF11B
7nitroglycerin45 119.9HIF1A, CHKB, PIK3C2A, NPPB, TNFRSF11B
8vincristine45 50 1110.9NPPB, ADA, HIF1A, TNFSF10, VIM, TOP1
9irinotecan45 50 1110.9ALB, VEGFA, CEACAM3, TOP1, TNFSF10
10heparin45 29 11 2411.8CHKB, VEGFA, S100B, TNFRSF11B, PIK3C2A, TOP1
11trastuzumab45 50 1110.8HIF1A, VEGFA, NPPB, TNFSF10, MUC1
12celecoxib45 60 29 50 11 2413.8HIF1A, ALB, TNFSF10, TNFRSF11B, VEGFA, FGF2
13hematoxylin458.7CEACAM3, MUC16, PSG2, S100B, VIM
14gefitinib45 50 1110.7VEGFA, TOP1, FGF2, ALB, TNFSF10, VIM
15aspartate458.6ALB, CEACAM3, CHKB, TOP1, PIK3C2A, ADA
16topotecan45 119.6HIF1A, MUC16, TOP1, TNFSF10, VEGFA
17adriamycin458.6VIM, CEACAM3, TOP1, PSG2, HIF1A, MUC1
18b 723458.5S100B, PSG2, MUC16, MUC1, VIM, CEACAM3
19melphalan45 119.5TNFSF10, TOP1, CHKB, PIK3C2A, MUC16
205fluorouracil458.4CEACAM3, HIF1A, VEGFA, TOP1, TNFSF10, MUC1
21ascorbic acid45 249.4TNFRSF11B, PIK3C2A, CHKB, FGF2, ALB, S100B
22estradiol45 11 2410.3CHKB, MUC16, VIM, NPPB, PIK3C2A
23paclitaxel45 50 1110.3S100B, ADA, VEGFA, HIF1A, TOP1, TNFSF10
24sb 20358045 609.2TNFSF10, TNFRSF11B, FGF2, VEGFA, NPPB, HIF1A
25pyruvate458.2HIF1A, CHKB, PIK3C2A, TNFSF10, S100B, MUC1
26thymidine45 249.2MUC1, PSG2, S100B, HIF1A, FGF2, CEACAM3
27gold458.1PIK3C2A, MUC16, MUC1, CEACAM3, TNFRSF11B, PSG2
28hyaluronic acid45 249.1VIM, MUC16, VEGFA, MUC1, FGF2, ALB
29thyroxine45 249.0TNFRSF11B, NPPB, ALB, PIK3C2A, CHKB, FGF2
30actinomycin d458.0NPPB, TOP1, VEGFA, VIM, HIF1A, MUC1
31bicarbonate458.0MUC16, NPPB, PIK3C2A, ALB, CHKB
32genistein45 29 60 2 11 2412.9FGF2, HIF1A, VIM, NPPB, VEGFA, TNFRSF11B
33cyclosporin a45 29 609.9TNFSF10, FGF2, HIF1A, CHKB, PIK3C2A, NPPB
34nitric oxide45 11 249.9CHKB, CEACAM3, PSG2, HIF1A, MUC1, TNFRSF11B
35h2o2457.8VIM, FGF2, TNFSF10, TOP1, CHKB, HIF1A
36prednisolone45 29 119.7MUC16, PIK3C2A, ALB, NPPB, TNFRSF11B, CHKB
37dexamethasone45 50 29 1110.5MUC16, TNFSF10, S100B, FGF2, TNFRSF11B, NPPB
38methotrexate45 50 119.5VIM, TNFSF10, TNFRSF11B, PIK3C2A, CHKB, HIF1A
39alanine457.5CEACAM3, FGF2, VIM, ADA, CHKB, PIK3C2A
40lipid457.2S100B, PSG2, ACADVL, MUC1, VIM, ALB
41paraffin457.2FGF2, VIM, CEACAM3, HIF1A, CHKB, PSG2
42iron45 248.0MUC16, VIM, S100B, TNFSF10, PIK3C2A, TNFRSF11B
43progesterone45 60 29 11 2411.0TNFSF10, S100B, VIM, MUC16, PIK3C2A, NPPB
44glucose456.9MUC16, CHKB, ACADVL, CEACAM3, PSG2, NPPB
45creatinine456.8ADA, PSG2, NPPB, TNNI3, TNFRSF11B, PIK3C2A
46testosterone45 60 11 249.6CHKB, S100B, HIF1A, MUC16, MUC1, ALB
47lactate456.3ADA, ALB, CEACAM3, MUC16, HIF1A, PIK3C2A
48doxorubicin45 50 118.0PIK3C2A, TOP1, VEGFA, HIF1A, MUC16, CEACAM3
49tyrosine455.7TNFSF10, NPPB, FGF2, MUC1, TNFRSF11B, PIK3C2A
50vegf455.3HIF1A, MUC16, MUC1, FGF2, CEACAM3, ADA

GO Terms for genes affiliated with Pericardial Effusion

Sources:
16Gene Ontology
See all sources

Cellular components related to Pericardial Effusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.5S100B, TNFSF10, TNFRSF11B, NPPB, PSG2, VEGFA
2extracellular spaceGO:0056156.7S100B, TNFSF10, TNFRSF11B, NPPB, VEGFA, MUC16

Biological processes related to Pericardial Effusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614199.7VEGFA, HIF1A
2positive regulation of angiogenesisGO:0457669.4HIF1A, FGF2, VEGFA
3positive regulation of endothelial cell proliferationGO:0019389.3FGF2, HIF1A, VEGFA
4cellular response to hypoxiaGO:0714569.1VEGFA, HIF1A, S100B

Molecular functions related to Pericardial Effusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.2FGF2, VEGFA, TNFRSF11B, TNFSF10

Products for genes affiliated with Pericardial Effusion

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  • Proteins
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Sources for Pericardial Effusion

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet