MCID: PRC012
MIFTS: 54

Pericardial Effusion malady

Cardiovascular diseases category

Summaries for Pericardial Effusion

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Pericardial effusion (\"fluid around the heart\") is an abnormal accumulation of fluid in the... more...

MalaCards: Pericardial Effusion is related to pericarditis and hypothyroidism. An important gene associated with Pericardial Effusion is ADA (adenosine deaminase), and among its related pathways are Integrins in angiogenesis and Development Ligand-dependent activation of the ESR1/AP-1 pathway. The compounds estrogen and tamoxifen have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and breast, and related mouse phenotypes are tumorigenesis and skeleton.

Disease Ontology:8 A heart disease that is characterized by an abnormal accumulation of fluid in the pericardial cavity.

Aliases & Classifications for Pericardial Effusion

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

pericardial effusion 8 10 44 60


External Ids:

Disease Ontology8 DOID:118
MeSH34 D010490
SNOMED-CT56 70370001, 373945007
NCIt39 C3319
ICD1025 I31.3

Related Diseases for Pericardial Effusion

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17GeneCards, 18GeneDecks
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Diseases related to Pericardial Effusion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 382)
idRelated DiseaseScoreTop Affiliating Genes
1pericarditis31.1ADA, PSG2
2hypothyroidism30.9CHKB, PIK3C2A
3leukemia30.7ADA, FGF2, TOP1, PSG2, TNFSF10
4constrictive pericarditis30.6ADA, NPPB
5arthritis30.6ALB, FGF2, TNFRSF11B
6angiosarcoma30.6MUC1, VIM
7myocardial infarction30.6HIF1A, CHKB, PIK3C2A, NPPB, TNNI3
8adenocarcinoma30.5ADA, CEACAM3, MUC1, MUC16, HIF1A, VEGFA
9down syndrome30.5S100B
10hypertension30.5ALB, NPPB
11rheumatoid arthritis30.5ADA, VEGFA, CHKB, TOP1, TNFRSF11B
12lung cancer30.5MUC16, HIF1A, VEGFA, TOP1, PSG2, TNFSF10
13ventricular septal defect30.5TNNI3
14myocarditis30.5CHKB, NPPB, TNNI3
15acute leukemia30.4TOP1, TNFSF10
16peritonitis30.4ADA, ALB, MUC16
17sarcoma30.4ADA, MUC1, TOP1, S100B, VIM
18thymoma30.2CEACAM3
19acute pancreatitis30.2PSG2
20systemic scleroderma30.2TOP1
21pancreatitis30.2ALB
22connective tissue disease30.2ALB
23meningitis30.2ADA, ALB
24cholestasis30.2ALB, CEACAM3
25acute myocardial infarction30.2CHKB, PIK3C2A, NPPB, TNNI3
26malignant mesothelioma30.2CEACAM3, FGF2, MUC1, MUC16, TNFSF10, VIM
27melanoma30.2ADA, CEACAM3, FGF2, HIF1A, VEGFA, CHKB
28breast cancer30.2ADA, ALB, CEACAM3, FGF2, MUC1, MUC16
29sarcoidosis30.0ADA
30respiratory failure30.0PIK3C2A
31legionnaires' disease30.0PIK3C2A
32anorexia nervosa30.0TNFRSF11B
33polymyositis30.0CHKB, PIK3C2A
34myositis30.0CHKB, PIK3C2A
35nephrotic syndrome30.0ALB
36myeloid leukemia30.0TOP1, TNFSF10
37duchenne muscular dystrophy30.0CHKB, PIK3C2A, TNNI3
38cystic fibrosis30.0ALB, TNFRSF11B
39stroke, ischemic30.0ALB, S100B
40atrioventricular block30.0PIK3C2A, NPPB
41dermatomyositis30.0MUC1, MUC16, CHKB, PIK3C2A
42dilated cardiomyopathy30.0CHKB, PIK3C2A, NPPB, TNNI3
43synovial sarcoma30.0MUC1, S100B, VIM
44cervical cancer30.0MUC16, HIF1A, PSG2, TNFSF10
45leiomyosarcoma30.0MUC1, MUC16, S100B, VIM
46adenoid cystic carcinoma30.0CEACAM3, MUC1, S100B, VIM
47atherosclerosis30.0ALB, FGF2, TNFRSF11B, TNFSF10
48benign mesothelioma30.0ADA, CEACAM3, MUC1, MUC16, PSG2, TNFSF10
49lung adenocarcinoma30.0CEACAM3, MUC1, MUC16, HIF1A, VEGFA, TOP1
50ischemia30.0FGF2, HIF1A, VEGFA, CHKB, PIK3C2A, NPPB

Graphical network of the top 20 diseases related to Pericardial Effusion:



Diseases related to pericardial effusion

Clinical Features for Pericardial Effusion

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Drugs & Therapeutics for Pericardial Effusion

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Pericardial Effusion

Search NIH Clinical Center for Pericardial Effusion

Search CenterWatch for Pericardial Effusion

Genetic Tests for Pericardial Effusion

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Anatomical Context for Pericardial Effusion

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32MalaCards
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MalaCards organs/tissues related to Pericardial Effusion:

32
Heart, Lung, Breast, Endothelial, Kidney, T cells, Myeloid, Salivary gland, Pituitary, Thyroid, Testes, Whole blood, Brain, Spinal cord, Liver, Bone, Prostate

Animal Models for Pericardial Effusion or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pericardial Effusion:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.7TNFSF10, ACADVL, ALB
2MP:00053909.0FGF2, VEGFA, CHKB, TNFRSF11B, TNFSF10
3MP:00053698.8ACADVL, FGF2, HIF1A, CHKB, NPPB, TNNI3
4MP:00053768.8PIK3C2A, CHKB, ACADVL, ALB, ADA
5MP:00053858.6VIM, TNFRSF11B, TNNI3, NPPB, ACADVL
6MP:00053708.3TNFSF10, VEGFA, HIF1A, MUC1, ACADVL, ALB
7MP:00107686.6VIM, TNFSF10, TNFRSF11B, TNNI3, PIK3C2A, TOP1

Publications for Pericardial Effusion

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50PubMed
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Articles related to Pericardial Effusion:

(show top 50)    (show all 570)
idTitleAuthorsYear
1
Myopericarditis in tuberculous pericardial effusion: prevalence, predictors and outcome. (24254192)
2014
2
Detection of EGFR T790M Mutation in Pericardial Effusion from a Non-Small Cell Lung Cancer Patient with Erlotinib Therapy. (23466741)
2013
3
Management of pericardial effusion. (23125278)
2013
4
Incidental detection of pericardial effusion on bone scan. (23242050)
2013
5
Fetal right-ventricular hypertrophy with pericardial effusion and maternal untreated hyperthyroidism. (23179424)
2013
6
Hydralazine-induced lupus syndrome presenting with large pericardial effusion. (24194564)
2013
7
Coronary aneurysm and purulent pericardial effusion: old disease with an unusual cause. (23608264)
2013
8
The potential additional diagnostic value of assessing for pericardial effusion on cardiac magnetic resonance imaging in patients with suspected myocarditis. (24378485)
2013
9
Prognostic relevance of pericardial effusion in patients with malignant diseases. (23071482)
2012
10
Quantification of echodensities in tuberculous pericardial effusion using fractal geometry: a proof of concept study. (22838492)
2012
11
The role of bedside ultrasound in the diagnosis of pericardial effusion and cardiac tamponade. (22416160)
2012
12
Percutaneous drainage of postoperative pericardial effusion in cardiac surgery. (21981588)
2012
13
Real-time tele-echocardiography: diagnosis and management of a pericardial effusion secondary to pericarditis at an Antarctic research station. (22822790)
2012
14
A novel prognostic marker in acute ischemic stroke: small pericardial effusion. (22527238)
2012
15
Scientific letter: Ac-SDKP (N-acetyl-seryl-aspartyl-lysyl-proline) and Galectin-3 levels in tuberculous pericardial effusion: implications for pathogenesis and prevention of pericardial constriction. (22842991)
2012
16
Sudden cardiac arrest caused by tuberculous pericarditis with hemorrhagic pericardial effusion. (23154733)
2012
17
Fever, dyspnea and chest pain with pericardial effusion. Primary cardiac angiosarcoma. (22766238)
2012
18
Symptomatic pericardial effusion in Hodgkin's lymphoma: a rare occurrence. Case report and review of the literature. (22678004)
2012
19
The incidence of pleural and pericardial effusion is not higher in patients receiving dasatinib at low doses. (Reply). (21454871)
2011
20
Late postoperative pericardial effusion. (21843765)
2011
21
Effusive-constrictive pericarditis in the absence of overt pericardial disease on multiple imaging modalities. (22674954)
2011
22
Elderly woman with massive pericardial effusion, cardiac tamponade, and hypothyroidism. (21054308)
2010
23
Medical therapy of pericardial diseases: part II: Noninfectious pericarditis, pericardial effusion and constrictive pericarditis. (20925146)
2010
24
Cytologic aspects of T-cell acute lymphoblastic leukemia presenting as a massive pericardial effusion: a case report. (19534280)
2009
25
Postoperative pericardial effusion and posterior pericardiotomy: related? (19917788)
2009
26
A case of mitochondrial cardiomyopathy with pericardial effusion evaluated by (99m)Tc-MIBI myocardial scintigraphy. (19777318)
2009
27
A randomised trial of intrapericardial bleomycin for malignant pericardial effusion with lung cancer (JCOG9811). (19156149)
2009
28
Pericardial effusion causing echocardiographic mimicking of left intra-atrial thrombus. (18799477)
2009
29
Successful outcome after prenatal treatment of a cardiac diverticulum with massive pericardial effusion. (19287174)
2009
30
Cardiac rupture or pericardial effusion? (17692412)
2008
31
Lymphomatous pericardial effusion positive for Mycobacterium tuberculosis by PCR analysis. (18406651)
2008
32
Risk factors for pericardial effusion in inoperable esophageal cancer patients treated with definitive chemoradiation therapy. (18191334)
2008
33
Asymptomatic pericardial effusion in patients with rheumatoid arthritis. (17975311)
2008
34
Massive intractable pericardial effusion in a patient with systemic lupus erythematosus treated successfully with pericardial fenestration alone. (18852229)
2008
35
Mini-invasive thoracotomic drainage of pericardial effusion with a new device: a ''circular retractor'' (Morpheus). (18670393)
2008
36
Clozapine-induced pericardial effusion. (18626276)
2008
37
Pericardial effusion associated with an appropriately placed umbilical venous catheter. (17453042)
2007
38
Malignant pericardial effusion treated with intrapericardial bleomycin. (17472493)
2007
39
Breast implant mimicking pericardial effusion in a cancer patient undergoing gated heart pool radionuclide study. (17937644)
2007
40
Pericardial fat mimicking pericardial effusion on two-dimensional echocardiography. (16686623)
2006
41
Pneumopericardium followed by pericardial effusion after thoracic trauma and pacemaker implantation. (17036191)
2006
42
Cardiac diverticulum with pericardial effusion: report of two new cases treated by in-utero pericardiocentesis and a review of the literature. (15747327)
2005
43
Abnormal cytology predicts poor prognosis in cancer patients with pericardial effusion. (16051963)
2005
44
Left ventricular cardiac tamponade in the setting of cor pulmonale and circumferential pericardial effusion. Case report and review of the literature. (15949058)
2005
45
Fetal congenital cardiac diverticulum with pericardial effusion: two cases with different presentations in the first trimester of pregnancy. (15747330)
2005
46
Cardiac tamponade due to massive pericardial effusion in mixed connective tissue disease: reversal with steroid therapy. (15470773)
2004
47
Management of tuberculous constrictive pericarditis and tuberculous pericardial effusion in Transkei: results at 10 years follow-up. (15256610)
2004
48
Pericardial effusion due to primary cardiac lymphosarcoma in a dog. (14658732)
2003
49
An outbreak of erythema infectiosum among hospital staff members including a patient with pleural fluid and pericardial effusion. (8335751)
1993
50
CHRONIC PERICARDIAL EFFUSION COMPLICATING ENDOMYOCARDIAL FIBROSIS. (14051542)
1963

Genetic Variations for Pericardial Effusion

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Expression for genes affiliated with Pericardial Effusion

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pericardial Effusion

Search GEO for disease gene expression data for Pericardial Effusion.

Pathways for genes affiliated with Pericardial Effusion

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37NCBI BioSystems Database, 12EMD Millipore, 49PharmGKB, 55SinoBiological
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Pathways related to Pericardial Effusion according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0VEGFA
2
Development Ligand-dependent activation of the ESR1/AP-1 pathway
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9.5VEGFA, HIF1A, ADA
39.4HIF1A, VEGFA, FGF2
4
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9.1FGF2, VEGFA, PIK3C2A

Compounds for genes affiliated with Pericardial Effusion

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Pericardial Effusion according to GeneCards/GeneDecks:

(show top 50)    (show all 178)
idCompoundScoreTop Affiliating Genes
1estrogen4410.2CHKB, NPPB
2tamoxifen44 49 28 1112.9CEACAM3, CHKB, TNFSF10
3mucicarmine449.4VIM, MUC1, CEACAM3, S100B
4glycogen44 2410.1NPPB, PSG2, PIK3C2A, CHKB
5dihydrotestosterone44 28 11 2412.0MUC1, HIF1A, FGF2, TNFRSF11B, VIM, CHKB
6bortezomib44 1110.0HIF1A, TNFSF10, VEGFA, TOP1, TNFRSF11B
7nitroglycerin44 119.9HIF1A, CHKB, PIK3C2A, NPPB, TNFRSF11B
8vincristine44 49 1110.9NPPB, ADA, HIF1A, TNFSF10, VIM, TOP1
9irinotecan44 49 1110.9ALB, VEGFA, CEACAM3, TOP1, TNFSF10
10heparin44 28 11 2411.8CHKB, VEGFA, S100B, TNFRSF11B, PIK3C2A, TOP1
11trastuzumab44 49 1110.8HIF1A, VEGFA, NPPB, TNFSF10, MUC1
12celecoxib44 59 28 49 11 2413.8HIF1A, ALB, TNFSF10, TNFRSF11B, VEGFA, FGF2
13hematoxylin448.7CEACAM3, MUC16, PSG2, S100B, VIM
14gefitinib44 49 1110.7VEGFA, TOP1, FGF2, ALB, TNFSF10, VIM
15aspartate448.6ALB, CEACAM3, CHKB, TOP1, PIK3C2A, ADA
16topotecan44 119.6HIF1A, MUC16, TOP1, TNFSF10, VEGFA
17adriamycin448.6VIM, CEACAM3, TOP1, PSG2, HIF1A, MUC1
18b 723448.5S100B, PSG2, MUC16, MUC1, VIM, CEACAM3
19melphalan44 119.5TNFSF10, TOP1, CHKB, PIK3C2A, MUC16
205fluorouracil448.4CEACAM3, HIF1A, VEGFA, TOP1, TNFSF10, MUC1
21ascorbic acid44 249.4TNFRSF11B, PIK3C2A, CHKB, FGF2, ALB, S100B
22estradiol44 11 2410.3CHKB, MUC16, VIM, NPPB, PIK3C2A
23paclitaxel44 49 1110.3S100B, ADA, VEGFA, HIF1A, TOP1, TNFSF10
24sb 20358044 599.2TNFSF10, TNFRSF11B, FGF2, VEGFA, NPPB, HIF1A
25pyruvate448.2HIF1A, CHKB, PIK3C2A, TNFSF10, S100B, MUC1
26thymidine44 249.2MUC1, PSG2, S100B, HIF1A, FGF2, CEACAM3
27gold448.1PIK3C2A, MUC16, MUC1, CEACAM3, TNFRSF11B, PSG2
28hyaluronic acid44 249.1VIM, MUC16, VEGFA, MUC1, FGF2, ALB
29thyroxine44 249.0TNFRSF11B, NPPB, ALB, PIK3C2A, CHKB, FGF2
30actinomycin d448.0NPPB, TOP1, VEGFA, VIM, HIF1A, MUC1
31bicarbonate448.0MUC16, NPPB, PIK3C2A, ALB, CHKB
32genistein44 28 59 2 11 2412.9FGF2, HIF1A, VIM, NPPB, VEGFA, TNFRSF11B
33cyclosporin a44 28 599.9TNFSF10, FGF2, HIF1A, CHKB, PIK3C2A, NPPB
34nitric oxide44 11 249.9CHKB, CEACAM3, PSG2, HIF1A, MUC1, TNFRSF11B
35h2o2447.8VIM, FGF2, TNFSF10, TOP1, CHKB, HIF1A
36prednisolone44 28 119.7MUC16, PIK3C2A, ALB, NPPB, TNFRSF11B, CHKB
37dexamethasone44 49 28 1110.5MUC16, TNFSF10, S100B, FGF2, TNFRSF11B, NPPB
38methotrexate44 49 119.5VIM, TNFSF10, TNFRSF11B, PIK3C2A, CHKB, HIF1A
39alanine447.5CEACAM3, FGF2, VIM, ADA, CHKB, PIK3C2A
40lipid447.2S100B, PSG2, ACADVL, MUC1, VIM, ALB
41paraffin447.2FGF2, VIM, CEACAM3, HIF1A, CHKB, PSG2
42iron44 248.0MUC16, VIM, S100B, TNFSF10, PIK3C2A, TNFRSF11B
43progesterone44 59 28 11 2411.0TNFSF10, S100B, VIM, MUC16, PIK3C2A, NPPB
44glucose446.9MUC16, CHKB, ACADVL, CEACAM3, PSG2, NPPB
45creatinine446.8ADA, PSG2, NPPB, TNNI3, TNFRSF11B, PIK3C2A
46testosterone44 59 11 249.6CHKB, S100B, HIF1A, MUC16, MUC1, ALB
47lactate446.3ADA, ALB, CEACAM3, MUC16, HIF1A, PIK3C2A
48doxorubicin44 49 118.0PIK3C2A, TOP1, VEGFA, HIF1A, MUC16, CEACAM3
49tyrosine445.7TNFSF10, NPPB, FGF2, MUC1, TNFRSF11B, PIK3C2A
50vegf445.3HIF1A, MUC16, MUC1, FGF2, CEACAM3, ADA

GO Terms for genes affiliated with Pericardial Effusion

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16Gene Ontology
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Cellular components related to Pericardial Effusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.5S100B, TNFSF10, TNFRSF11B, NPPB, PSG2, VEGFA
2extracellular spaceGO:0056156.7S100B, TNFSF10, TNFRSF11B, NPPB, VEGFA, MUC16

Biological processes related to Pericardial Effusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614199.7VEGFA, HIF1A
2positive regulation of angiogenesisGO:0457669.4HIF1A, FGF2, VEGFA
3positive regulation of endothelial cell proliferationGO:0019389.3FGF2, HIF1A, VEGFA
4cellular response to hypoxiaGO:0714569.1VEGFA, HIF1A, S100B

Molecular functions related to Pericardial Effusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.2FGF2, VEGFA, TNFRSF11B, TNFSF10

Products for genes affiliated with Pericardial Effusion

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Sources for Pericardial Effusion

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet