MCID: PRC012
MIFTS: 54

Pericardial Effusion malady

Cardiovascular diseases category

Summaries for Pericardial Effusion

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Pericardial effusion (\"fluid around the heart\") is an abnormal accumulation of fluid in the... more...

MalaCards: Pericardial Effusion is related to pericarditis and hypothyroidism. An important gene associated with Pericardial Effusion is ADA (adenosine deaminase), and among its related pathways are Integrins in angiogenesis and Development Ligand-dependent activation of the ESR1/AP-1 pathway. The compounds estrogen and tamoxifen have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and breast, and related mouse phenotypes are tumorigenesis and skeleton.

Disease Ontology:8 A heart disease that is characterized by an abnormal accumulation of fluid in the pericardial cavity.

Aliases & Classifications for Pericardial Effusion

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

pericardial effusion 8 10 44 60


External Ids:

Disease Ontology8 DOID:118
MeSH34 D010490
SNOMED-CT56 70370001, 373945007
NCIt39 C3319
ICD1025 I31.3

Related Diseases for Pericardial Effusion

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17GeneCards, 18GeneDecks
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Diseases related to Pericardial Effusion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 382)
idRelated DiseaseScoreTop Affiliating Genes
1pericarditis31.1ADA, PSG2
2hypothyroidism30.9CHKB, PIK3C2A
3leukemia30.7ADA, FGF2, TOP1, PSG2, TNFSF10
4constrictive pericarditis30.6ADA, NPPB
5arthritis30.6ALB, FGF2, TNFRSF11B
6angiosarcoma30.6MUC1, VIM
7myocardial infarction30.6HIF1A, CHKB, PIK3C2A, NPPB, TNNI3
8adenocarcinoma30.5ADA, CEACAM3, MUC1, MUC16, HIF1A, VEGFA
9down syndrome30.5S100B
10hypertension30.5ALB, NPPB
11rheumatoid arthritis30.5ADA, VEGFA, CHKB, TOP1, TNFRSF11B
12lung cancer30.5MUC16, HIF1A, VEGFA, TOP1, PSG2, TNFSF10
13ventricular septal defect30.5TNNI3
14myocarditis30.5CHKB, NPPB, TNNI3
15acute leukemia30.4TOP1, TNFSF10
16peritonitis30.4ADA, ALB, MUC16
17sarcoma30.4ADA, MUC1, TOP1, S100B, VIM
18thymoma30.2CEACAM3
19acute pancreatitis30.2PSG2
20systemic scleroderma30.2TOP1
21pancreatitis30.2ALB
22connective tissue disease30.2ALB
23meningitis30.2ADA, ALB
24cholestasis30.2ALB, CEACAM3
25acute myocardial infarction30.2CHKB, PIK3C2A, NPPB, TNNI3
26malignant mesothelioma30.2CEACAM3, FGF2, MUC1, MUC16, TNFSF10, VIM
27melanoma30.2ADA, CEACAM3, FGF2, HIF1A, VEGFA, CHKB
28breast cancer30.2ADA, ALB, CEACAM3, FGF2, MUC1, MUC16
29sarcoidosis30.0ADA
30respiratory failure30.0PIK3C2A
31legionnaires' disease30.0PIK3C2A
32anorexia nervosa30.0TNFRSF11B
33polymyositis30.0CHKB, PIK3C2A
34myositis30.0CHKB, PIK3C2A
35nephrotic syndrome30.0ALB
36myeloid leukemia30.0TOP1, TNFSF10
37duchenne muscular dystrophy30.0CHKB, PIK3C2A, TNNI3
38cystic fibrosis30.0ALB, TNFRSF11B
39stroke, ischemic30.0ALB, S100B
40atrioventricular block30.0PIK3C2A, NPPB
41dermatomyositis30.0MUC1, MUC16, CHKB, PIK3C2A
42dilated cardiomyopathy30.0CHKB, PIK3C2A, NPPB, TNNI3
43synovial sarcoma30.0MUC1, S100B, VIM
44cervical cancer30.0MUC16, HIF1A, PSG2, TNFSF10
45leiomyosarcoma30.0MUC1, MUC16, S100B, VIM
46adenoid cystic carcinoma30.0CEACAM3, MUC1, S100B, VIM
47atherosclerosis30.0ALB, FGF2, TNFRSF11B, TNFSF10
48benign mesothelioma30.0ADA, CEACAM3, MUC1, MUC16, PSG2, TNFSF10
49lung adenocarcinoma30.0CEACAM3, MUC1, MUC16, HIF1A, VEGFA, TOP1
50ischemia30.0FGF2, HIF1A, VEGFA, CHKB, PIK3C2A, NPPB

Graphical network of the top 20 diseases related to Pericardial Effusion:



Diseases related to pericardial effusion

Clinical Features for Pericardial Effusion

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Drugs & Therapeutics for Pericardial Effusion

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Pericardial Effusion

Search NIH Clinical Center for Pericardial Effusion

Search CenterWatch for Pericardial Effusion

Genetic Tests for Pericardial Effusion

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Anatomical Context for Pericardial Effusion

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32MalaCards
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MalaCards organs/tissues related to Pericardial Effusion:

32
Heart, Lung, Breast, Kidney, Endothelial, Myeloid, T cells, Testes, Prostate, Bone, Salivary gland, Thyroid, Liver, Spinal cord, Brain, Whole blood, Pituitary

Animal Models for Pericardial Effusion or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pericardial Effusion:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.7TNFSF10, ACADVL, ALB
2MP:00053909.0FGF2, VEGFA, CHKB, TNFRSF11B, TNFSF10
3MP:00053698.8ACADVL, FGF2, HIF1A, CHKB, NPPB, TNNI3
4MP:00053768.8PIK3C2A, CHKB, ACADVL, ALB, ADA
5MP:00053858.6VIM, TNFRSF11B, TNNI3, NPPB, ACADVL
6MP:00053708.3TNFSF10, VEGFA, HIF1A, MUC1, ACADVL, ALB
7MP:00107686.6VIM, TNFSF10, TNFRSF11B, TNNI3, PIK3C2A, TOP1

Publications for Pericardial Effusion

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50PubMed
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Articles related to Pericardial Effusion:

(show top 50)    (show all 570)
idTitleAuthorsYear
1
Incidence and predictors of pericardial effusion after permanent heart rhythm device implantation: prospective evaluation of 968 consecutive patients. (23269085)
2013
2
Motion artifacts on coronary CT angiography images in patients with a pericardial effusion. (24238642)
2013
3
Lymphangiopathy in neurofibromatosis 1 manifesting with chylothorax, pericardial effusion, and leg edema. (24043952)
2013
4
Massive pericardial effusion caused by "inflammatory myofibroblastic tumour" in a 3-month-old child. (23176899)
2013
5
Transabdominal ligation of the thoracic duct with pericardial-peritoneal shunting in a case of primary idiopathic chylous pericardial effusion. (23845644)
2013
6
Risk factors affecting the survival rate in patients with symptomatic pericardial effusion undergoing surgical intervention. (23250960)
2013
7
First steps in the management of pericardial effusion: who was first to relieve the pericardial sac--Larrey or Romero? (23722467)
2013
8
Pericardial effusion and cardiac tamponade in neonates: sudden unexpected death associated with total parenteral nutrition via central venous catheterization. (23694791)
2013
9
Recurrent pericardial effusion caused by pacemaker lead perforation and warfarin therapy at seven years after implantation. (22266846)
2012
10
Idiopathic hemorrhagic pericardial effusion as a precursor to epicardial lymphosarcoma in three cows. (22676351)
2012
11
Sarcoidosis in a 65-year-old woman presenting with a lung mass and pericardial effusion: a case report. (22937889)
2012
12
Mycotic pseudoaneurysm of the aortic arch with purulent pericardial effusion. (22450083)
2012
13
Diastolic dysfunction, prolonged QTc interval and pericardial effusion as predictors of mortality in acute pancreatitis. (22849657)
2012
14
Large pericardial effusion induced by minoxidil. (22864322)
2012
15
Schwannoma in anterior mediastinum with massive pericardial effusion. (23239781)
2012
16
Large hemorrhagic pericardial effusion. (22891398)
2012
17
Short-term minoxidil use associated with pericardial effusion and cardiac tamponade: an uncommon presentation. (21519225)
2012
18
Ask the doctor. My doctor told me I have pericardial effusion. I know it has something to do with fluid in the heart. Can you tell me more? (21695862)
2011
19
A recurrent cerebrospinal fluid pericardial effusion. (22117915)
2011
20
Cardiac lymphoma causing coronary compression, pericardial effusion, and atrioventricular block. (20926364)
2011
21
Large pericardial effusion as a complication in adults undergoing SCT. (21113188)
2011
22
Epicardial lipomatous hypertrophy mimicking pericardial effusion: characterization with cardiovascular magnetic resonance. (21245365)
2011
23
Pericardial effusion in renal disease: to tap or not to tap. (22286154)
2011
24
Pericardial effusion post-SCT in pediatric recipients with signs and/or symptoms of cardiac disease. (20581882)
2011
25
Coumatetralyl rodenticide induced pericardial effusion - a comment. (22131571)
2011
26
Low-voltage electrocardiogram in patients with hypothyroidism and pericardial effusion: can serial comparative quantitative electrocardiography offer more? (20424450)
2010
27
Preliminary investigation of the clinical value of vascular endothelial growth factor and hypoxia-inducible factor-1alpha in pericardial fluid in diagnosing malignant and tuberculous pericardial effusion. (20424452)
2010
28
Fetal diagnosis of a cardiac diverticulum and pericardial effusion. (20484879)
2010
29
Usefulness of pericardioscopy in the diagnosis of pericardial effusion. (20549029)
2010
30
Link between pericardial effusion and attenuation of QRS voltage in patients with hypothyroidism. (20424451)
2010
31
Re: Pericardial effusion impending tamponade: a look beyond Beck's triad. (19497471)
2009
32
Asymptomatic pericardial effusion in patients with systemic lupus erythematosus. (19151113)
2009
33
Massive pericardial effusion treated with in utero pericardioamniotic shunt in a fetus with intrapericardial teratoma. (19842876)
2009
34
Microcavitation contrast method for the drainage of bloody pericardial effusion. (19933946)
2009
35
A case of tuberculous pericardial effusion. (19172070)
2009
36
Amplitudes of P waves and QRS complexes in patients with a pericardial effusion: a differentiation with a diagnostic content. (18571511)
2008
37
Association between parapneumonic effusion and pericardial effusion in a pediatric cohort. (18984649)
2008
38
Transient myeloproliferative disorder and eosinophilic pericardial effusion in a down syndrome neonate. (18363179)
2008
39
Adult onset Still's disease flared with pericardial effusion. (17668215)
2008
40
A 15-year-old girl with a large pericardial effusion. (17704946)
2008
41
Pericardial effusion due to Cryptococcus neoformans in a patient with cystic fibrosis following lung transplantation. (18207443)
2008
42
Large pericardial effusion requiring pericardiocentesis as cardinal sign of macrophage activation syndrome in systemic onset-juvenile idiopathic arthritis. (17160383)
2007
43
Incidence of pericardial effusion in females stimulated in "in vitro fertilization" program. (16999690)
2006
44
Resolution of large post-pericardiotomy pericardial effusion with colchicine. (16684071)
2006
45
Clinical factors associated with persistent pericardial effusion after successful primary coronary angioplasty. (16100170)
2005
46
Adenosine deaminase and carcinoembryonic antigen in pericardial effusion diagnosis, especially in suspected tuberculous pericarditis. (8205688)
1994
47
Pericardial effusion as a clinical sign of Legionnaires' disease. (2737786)
1989
48
Yellow nail syndrome associated with chronic pericardial effusion. (3608607)
1987
49
An adult case of mixed connective tissue disease associated with perimyocarditis and massive pericardial effusion. (3723788)
1986
50
A case of diffuse endomyocardial fibrosis of the right ventricle with persistent pericardial effusion. (1011370)
1976

Genetic Variations for Pericardial Effusion

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Expression for genes affiliated with Pericardial Effusion

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pericardial Effusion

Search GEO for disease gene expression data for Pericardial Effusion.

Pathways for genes affiliated with Pericardial Effusion

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37NCBI BioSystems Database, 12EMD Millipore, 49PharmGKB, 55SinoBiological
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Pathways related to Pericardial Effusion according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0VEGFA
2
Development Ligand-dependent activation of the ESR1/AP-1 pathway
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9.5VEGFA, HIF1A, ADA
39.4FGF2, HIF1A, VEGFA
4
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9.1FGF2, VEGFA, PIK3C2A

Compounds for genes affiliated with Pericardial Effusion

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Pericardial Effusion according to GeneCards/GeneDecks:

(show top 50)    (show all 178)
idCompoundScoreTop Affiliating Genes
1estrogen4410.2CHKB, NPPB
2tamoxifen44 49 28 1112.9CEACAM3, CHKB, TNFSF10
3mucicarmine449.4VIM, MUC1, CEACAM3, S100B
4glycogen44 2410.1NPPB, PSG2, PIK3C2A, CHKB
5dihydrotestosterone44 28 11 2412.0MUC1, HIF1A, FGF2, TNFRSF11B, VIM, CHKB
6bortezomib44 1110.0HIF1A, TNFSF10, VEGFA, TOP1, TNFRSF11B
7nitroglycerin44 119.9HIF1A, CHKB, PIK3C2A, NPPB, TNFRSF11B
8vincristine44 49 1110.9NPPB, ADA, HIF1A, TNFSF10, VIM, TOP1
9irinotecan44 49 1110.9ALB, VEGFA, CEACAM3, TOP1, TNFSF10
10heparin44 28 11 2411.8CHKB, VEGFA, S100B, TNFRSF11B, PIK3C2A, TOP1
11trastuzumab44 49 1110.8HIF1A, VEGFA, NPPB, TNFSF10, MUC1
12celecoxib44 59 28 49 11 2413.8HIF1A, ALB, TNFSF10, TNFRSF11B, VEGFA, FGF2
13hematoxylin448.7CEACAM3, MUC16, PSG2, S100B, VIM
14gefitinib44 49 1110.7VEGFA, TOP1, FGF2, ALB, TNFSF10, VIM
15aspartate448.6ALB, CEACAM3, CHKB, TOP1, PIK3C2A, ADA
16topotecan44 119.6HIF1A, MUC16, TOP1, TNFSF10, VEGFA
17adriamycin448.6VIM, CEACAM3, TOP1, PSG2, HIF1A, MUC1
18b 723448.5S100B, PSG2, MUC16, MUC1, VIM, CEACAM3
19melphalan44 119.5TNFSF10, TOP1, CHKB, PIK3C2A, MUC16
205fluorouracil448.4CEACAM3, HIF1A, VEGFA, TOP1, TNFSF10, MUC1
21ascorbic acid44 249.4TNFRSF11B, PIK3C2A, CHKB, FGF2, ALB, S100B
22estradiol44 11 2410.3CHKB, MUC16, VIM, NPPB, PIK3C2A
23paclitaxel44 49 1110.3S100B, ADA, VEGFA, HIF1A, TOP1, TNFSF10
24sb 20358044 599.2TNFSF10, TNFRSF11B, FGF2, VEGFA, NPPB, HIF1A
25pyruvate448.2HIF1A, CHKB, PIK3C2A, TNFSF10, S100B, MUC1
26thymidine44 249.2MUC1, PSG2, S100B, HIF1A, FGF2, CEACAM3
27gold448.1PIK3C2A, MUC16, MUC1, CEACAM3, TNFRSF11B, PSG2
28hyaluronic acid44 249.1VIM, MUC16, VEGFA, MUC1, FGF2, ALB
29thyroxine44 249.0TNFRSF11B, NPPB, ALB, PIK3C2A, CHKB, FGF2
30actinomycin d448.0NPPB, TOP1, VEGFA, VIM, HIF1A, MUC1
31bicarbonate448.0MUC16, NPPB, PIK3C2A, ALB, CHKB
32genistein44 28 59 2 11 2412.9FGF2, HIF1A, VIM, NPPB, VEGFA, TNFRSF11B
33cyclosporin a44 28 599.9TNFSF10, FGF2, HIF1A, CHKB, PIK3C2A, NPPB
34nitric oxide44 11 249.9CHKB, CEACAM3, PSG2, HIF1A, MUC1, TNFRSF11B
35h2o2447.8VIM, FGF2, TNFSF10, TOP1, CHKB, HIF1A
36prednisolone44 28 119.7MUC16, PIK3C2A, ALB, NPPB, TNFRSF11B, CHKB
37dexamethasone44 49 28 1110.5MUC16, TNFSF10, S100B, FGF2, TNFRSF11B, NPPB
38methotrexate44 49 119.5VIM, TNFSF10, TNFRSF11B, PIK3C2A, CHKB, HIF1A
39alanine447.5CEACAM3, FGF2, VIM, ADA, CHKB, PIK3C2A
40lipid447.2S100B, PSG2, ACADVL, MUC1, VIM, ALB
41paraffin447.2FGF2, VIM, CEACAM3, HIF1A, CHKB, PSG2
42iron44 248.0MUC16, VIM, S100B, TNFSF10, PIK3C2A, TNFRSF11B
43progesterone44 59 28 11 2411.0TNFSF10, S100B, VIM, MUC16, PIK3C2A, NPPB
44glucose446.9MUC16, CHKB, ACADVL, CEACAM3, PSG2, NPPB
45creatinine446.8ADA, PSG2, NPPB, TNNI3, TNFRSF11B, PIK3C2A
46testosterone44 59 11 249.6CHKB, S100B, HIF1A, MUC16, MUC1, ALB
47lactate446.3ADA, ALB, CEACAM3, MUC16, HIF1A, PIK3C2A
48doxorubicin44 49 118.0PIK3C2A, TOP1, VEGFA, HIF1A, MUC16, CEACAM3
49tyrosine445.7TNFSF10, NPPB, FGF2, MUC1, TNFRSF11B, PIK3C2A
50vegf445.3HIF1A, MUC16, MUC1, FGF2, CEACAM3, ADA

GO Terms for genes affiliated with Pericardial Effusion

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16Gene Ontology
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Cellular components related to Pericardial Effusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.5TNFSF10, TNFRSF11B, NPPB, PSG2, VEGFA, MUC1
2extracellular spaceGO:0056156.7ADA, S100B, TNFSF10, TNFRSF11B, NPPB, VEGFA

Biological processes related to Pericardial Effusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614199.7HIF1A, VEGFA
2positive regulation of angiogenesisGO:0457669.4FGF2, HIF1A, VEGFA
3positive regulation of endothelial cell proliferationGO:0019389.3FGF2, HIF1A, VEGFA
4cellular response to hypoxiaGO:0714569.1S100B, VEGFA, HIF1A

Molecular functions related to Pericardial Effusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.2FGF2, VEGFA, TNFRSF11B, TNFSF10

Products for genes affiliated with Pericardial Effusion

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Sources for Pericardial Effusion

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet