MCID: PRC012
MIFTS: 58

Pericardial Effusion malady

Cardiovascular diseases category
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Summaries for Pericardial Effusion

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Disease Ontology:8 A pericardium disease that is characterized by an abnormal accumulation of fluid in the pericardial cavity.

MalaCards based summary: Pericardial Effusion is related to pericarditis and constrictive pericarditis. An important gene associated with Pericardial Effusion is ADA (adenosine deaminase), and among its related pathways are Transcription Ligand dependent activation of the ESR1 SP pathway and Angiogenesis. The compounds nitroglycerin and mucicarmine have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and breast, and related mouse phenotypes are skeleton and cardiovascular system.

Wikipedia:65 Pericardial effusion (\"fluid around the heart\") is an abnormal accumulation of fluid in the... more...

Aliases & Classifications for Pericardial Effusion

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
See all sources

Pericardial Effusion, Aliases & Descriptions:

Name: Pericardial Effusion 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology8 DOID:118
MeSH34 D010490
SNOMED-CT57 70370001, 373945007
NCIt39 C3319
ICD1025 I31.3

Related Diseases for Pericardial Effusion

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Diseases related to Pericardial Effusion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 349)
idRelated DiseaseScoreTop Affiliating Genes
1pericarditis32.0PSG2, ADA
2constrictive pericarditis31.5ADA, NPPB
3dysphagia31.2PIK3C2A
4legionnaires' disease31.0PIK3C2A
5bronchogenic cyst31.0MUC16
6cardiac rupture31.0CHKB
7myocardial infarction30.9PIK3C2A, HIF1A, CHKB, NPPB
8peritonitis30.9MUC16, ADA, ALB
9atrioventricular block30.7NPPB, PIK3C2A
10dilated cardiomyopathy30.6NPPB, CHKB, PIK3C2A
11acute myocardial infarction30.6PIK3C2A, CHKB, NPPB
12dermatomyositis30.5PIK3C2A, MUC16, MUC1, CHKB
13rheumatoid arthritis30.4VEGFA, TNFRSF11B, ADA, TOP1, CHKB
14fibroma30.4VIM, MUC16
15synovial sarcoma30.3VIM, MUC1, S100B
16sarcoma30.2S100B, TOP1, ADA, MUC1, VIM
17cervical cancer30.2TNFSF10, HIF1A, MUC16, PSG2
18leiomyosarcoma30.2VIM, MUC16, MUC1, S100B
19pulmonary embolism30.1ALB, NPPB
20lung cancer30.0VEGFA, TNFSF10, HIF1A, MUC16, TOP1, PSG2
21malignant mesothelioma29.6TNFSF10, VIM, MUC16, MUC1, CEACAM3, FGF2
22lung adenocarcinoma29.5VEGFA, TNFSF10, HIF1A, MUC16, MUC1, TOP1
23ischemia29.4PIK3C2A, VEGFA, TNFRSF11B, HIF1A, CHKB, NPPB
24adenocarcinoma29.2VEGFA, TNFSF10, HIF1A, VIM, MUC16, MUC1
25melanoma28.3S100B, PSG2, CEACAM3, CHKB, TOP1, ADA
26breast cancer28.1MUC16, HIF1A, TNFRSF11B, TNFSF10, VEGFA, MUC1
27cardiac tamponade10.9
28hypothyroidism10.7
29mediastinitis10.6
30gas gangrene10.5PIK3C2A
31leukemia10.5
32transitional meningioma10.5MUC1
33hidradenoma10.5MUC1
34arthritis10.5
35neuroleptic malignant syndrome10.5PIK3C2A, CHKB
36status asthmaticus10.5PIK3C2A
37tuberculous peritonitis10.5MUC16, ADA
38ovarian serous cystadenocarcinoma10.5MUC16
39aseptic meningitis10.5ADA, CHKB
40pleural tuberculosis10.5ADA, PSG2
41creatine phosphokinase, elevated serum10.5PIK3C2A, CHKB
42hypertension10.5
43systemic lupus erythematosus10.5
44endomyocardial fibrosis10.5
45erdheim-chester disease10.5
46angiosarcoma10.5
47lupus erythematosus10.5
48cardiogenic shock10.5PIK3C2A, NPPB
49protein-losing enteropathy10.4ALB
50adenomatoid tumor10.4VIM

Graphical network of the top 20 diseases related to Pericardial Effusion:



Diseases related to pericardial effusion

Symptoms for Pericardial Effusion

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Drugs & Therapeutics for Pericardial Effusion

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Drug clinical trials:

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Search NIH Clinical Center for Pericardial Effusion

Genetic Tests for Pericardial Effusion

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Anatomical Context for Pericardial Effusion

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MalaCards organs/tissues related to Pericardial Effusion:

32
Heart, Lung, Breast, Kidney, Endothelial, Myeloid, T cells, Bone, Whole blood, Brain, Spinal cord, Liver, Thyroid, Salivary gland, Prostate, Testes, B cells, Pituitary

Animal Models for Pericardial Effusion or affiliated genes

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MGI Mouse Phenotypes related to Pericardial Effusion:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.3VEGFA, TNFSF10, TNFRSF11B, HIF1A, ADA, CHKB
2MP:00053858.2TNFRSF11B, HIF1A, VIM, ACADVL, NPPB, FGF2
3MP:00053708.1VEGFA, TNFSF10, HIF1A, MUC1, ADA, ACADVL
4MP:00020068.1VEGFA, TNFSF10, HIF1A, MUC1, ACADVL, ALB
5MP:00053698.0FGF2, VEGFA, HIF1A, VIM, CHKB, ACADVL
6MP:00053847.4VEGFA, TNFRSF11B, HIF1A, VIM, ADA, ACADVL
7MP:00053977.3PIK3C2A, VEGFA, TNFSF10, TNFRSF11B, HIF1A, VIM
8MP:00053766.7PIK3C2A, VEGFA, TNFSF10, HIF1A, VIM, MUC1
9MP:00107686.6PIK3C2A, VEGFA, TNFSF10, TNFRSF11B, HIF1A, VIM

Publications for Pericardial Effusion

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Articles related to Pericardial Effusion:

(show top 50)    (show all 577)
idTitleAuthorsYear
1
A new strategy for pericardiocentesis with a visual puncture system: the feasibility and efficiency study in a pericardial effusion model. (25300658)
2014
2
Electrical alternans due to large bilateral pleural effusion without pericardial effusion. (25129296)
2014
3
Idiopathic pericarditis and pericardial effusion in children: contemporary epidemiology and management. (25380671)
2014
4
Central venous catheter-induced pericardial effusion in a neonate: a case study and recommendations for practice. (25391594)
2014
5
Malignant pericardial effusion: still a long way to Ithaca? (23615155)
2013
6
Pulmonary hypertension complicated by pericardial effusion: a single center experience. (23258502)
2013
7
Thoracoscopic pericardial window fora88management of pericardial effusion in 15 dogs. (24106985)
2013
8
Erdheim-Chester Disease With Prominent Pericardial Effusion: Cytologic Findings and Review of the Literature. (23447119)
2013
9
Coexistence of cardiomyopathy and pericardial effusion : A challenging diagnosis. (24154881)
2013
10
Incidence and predictors of pericardial effusion after permanent heart rhythm device implantation: prospective evaluation of 968 consecutive patients. (23269085)
2013
11
A massive occult pericardial effusion in an athletic young male. (23720597)
2013
12
Long-term course of stemi complicated by a moderate to severe pericardial effusion. Frequency of left ventricular pseudoaneurysm. (22078975)
2012
13
Recurrent pericardial effusion caused by pacemaker lead perforation and warfarin therapy at seven years after implantation. (22266846)
2012
14
Prognostic relevance of pericardial effusion in patients with malignant diseases. (23071482)
2012
15
Cytokines in pericardial effusion of patients with inflammatory pericardial disease. (22577248)
2012
16
Pericardial effusion and the unsuspected culprit. (23174740)
2012
17
Letter by Kern regarding article, "High-pressure loculated pericardial effusion in postpericardiotomy syndrome". (23213000)
2012
18
Infantile cardiac haemangioma with large pericardial effusion diagnosed during acute bronchiolitis episode. (22250834)
2012
19
Massive pericardial effusion and multiple pericardial masses due to an anterior mediastinal teratoma rupturing in pericardial sac. (23087278)
2012
20
Quantification of echodensities in tuberculous pericardial effusion using fractal geometry: a proof of concept study. (22838492)
2012
21
The N-terminal pro-B-type natriuretic peptide as a predictor of disease progression in patients with pericardial effusion. (21194766)
2012
22
Pericardial effusion as a crucial presentation of Erdheim-Chester disease in a hemodialysis patient: an overlooked diagnosis. (22732342)
2012
23
Anuric acute renal failure associated with pericardial effusion without signs of cardiac tamponade. (22880811)
2012
24
Morgagni hernia with massive pericardial effusion diagnosed in the second trimester: prenatal diagnosis and perinatal management. (20714116)
2011
25
Percutaneous balloon pericardiotomy for recurrent malignant pericardial effusion. (22088990)
2011
26
False-positive pericardial effusion due to breast attenuation on equilibrium radionuclide angiocardiography. (21565955)
2011
27
A rare case of situs inversus with dextrocardia, lutembacher syndrome, and pericardial effusion. (22567197)
2011
28
Case report: Percutaneous balloon pericardiotomy using Inoue balloon for patients with massive pericardial effusion. (18778860)
2010
29
Echocardiography of isolated subacute left heart tamponade in a patient with cor pulmonale and circumferential pericardial effusion. (20630052)
2010
30
Hashitoxicosis with pericardial effusion. (19403186)
2010
31
Cytologic aspects of T-cell acute lymphoblastic leukemia presenting as a massive pericardial effusion: a case report. (19534280)
2009
32
Re: Pericardial effusion impending tamponade: a look beyond Beck's triad. (19497471)
2009
33
Pericardial effusion and developing tamponade in a 30-year-old man. (18717255)
2008
34
Cardiac rupture or pericardial effusion? (17692412)
2008
35
Pericardial effusion as the only manifestation of infection with Francisella tularensis: a case report. (18554395)
2008
36
Prognosis of large, symptomatic pericardial effusion treated by echo-guided percutaneous pericardiocentesis. (19006110)
2008
37
Emergency department echocardiography demonstrates large pericardial effusion and pendulous cardiac motion in patient with shortness of breath and electrical alternans. (19086327)
2008
38
Large pericardial effusion requiring pericardiocentesis as cardinal sign of macrophage activation syndrome in systemic onset-juvenile idiopathic arthritis. (17160383)
2007
39
Pericardial effusion associated with an appropriately placed umbilical venous catheter. (17453042)
2007
40
Pericardial effusion due to hypothyroidism in Down syndrome: report of four cases. (17435671)
2007
41
Correct diagnosis and successful treatment for pericardial effusion due to toothpick injury: a case report and literature review. (17696263)
2007
42
Pleural and pericardial effusion: a potential ultrasonographic marker for the prenatal differential diagnosis between congenital diaphragmatic eventration and congenital diaphragmatic hernia. (17366518)
2007
43
Etiological diagnosis of pericardial effusion. (17661668)
2006
44
Characterization of IL-2-activated TILs and their use in intrapericardial immunotherapy in malignant pericardial effusion. (16362409)
2006
45
Cardiac diverticulum with pericardial effusion: report of two new cases treated by in-utero pericardiocentesis and a review of the literature. (15747327)
2005
46
Solitary fibrous tumor of the pericardium presenting itself as a pericardial effusion and right ventricular obstruction. (15365524)
2004
47
Methysergide-induced retroperitoneal fibrosis and pericardial effusion. (15151680)
2004
48
Pericardial effusion and cardiomyopathy following arthritis with parvovirus B19 infection: response to intravenous immunoglobulin. (17039168)
2001
49
An adult case of mixed connective tissue disease associated with perimyocarditis and massive pericardial effusion. (3723788)
1986
50
Endomyocardial fibrosis presenting as chronic pericardial effusion. (5678613)
1968

Variations for Pericardial Effusion

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Expression for genes affiliated with Pericardial Effusion

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Expression patterns in normal tissues for genes affiliated with Pericardial Effusion

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Pathways for genes affiliated with Pericardial Effusion

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Pathways related to Pericardial Effusion according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
9.5VEGFA, HIF1A, ADA
2
Show member pathways
Angiogenesis37
9.4FGF2, HIF1A, VEGFA
3
Show member pathways
9.1FGF2, VEGFA, PIK3C2A
49.1FGF2, VEGFA, PIK3C2A

Compounds for genes affiliated with Pericardial Effusion

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Compounds related to Pericardial Effusion according to GeneCards/GeneDecks:

(show top 50)    (show all 226)
idCompoundScoreTop Affiliating Genes
1nitroglycerin44 1110.1NPPB, CHKB, HIF1A, TNFRSF11B, PIK3C2A
2mucicarmine448.9VIM, S100B, CEACAM3, MUC1
3trastuzumab44 50 1110.9VEGFA, TNFSF10, MUC1, NPPB, HIF1A
4dihydrotestosterone44 28 24 1111.8FGF2, HIF1A, TNFRSF11B, VIM, MUC1, CHKB
5vincristine44 50 1110.7ADA, TNFSF10, HIF1A, VIM, TOP1, NPPB
6celecoxib44 61 28 50 24 1113.5HIF1A, VEGFA, FGF2, ALB, TNFSF10, TNFRSF11B
7topotecan44 119.5HIF1A, TNFSF10, VEGFA, TOP1, MUC16
8gefitinib44 50 1110.5FGF2, TOP1, VIM, TNFSF10, VEGFA, ALB
9adriamycin448.5VIM, HIF1A, CEACAM3, TOP1, MUC1, TNFSF10
10thymidine44 249.4PSG2, CEACAM3, MUC1, CHKB, HIF1A, NPPB
11glycogen44 249.4VIM, CHKB, PSG2, S100B, PIK3C2A, MUC1
12b 723448.4S100B, CEACAM3, PSG2, MUC1, MUC16, VIM
135fluorouracil448.4VEGFA, TOP1, TNFSF10, CEACAM3, MUC1, HIF1A
14irinotecan44 50 1110.4TNFSF10, ALB, VEGFA, HIF1A, TOP1, CEACAM3
15sb 20358044 619.3FGF2, NPPB, VEGFA, TNFSF10, TNFRSF11B, HIF1A
16hematoxylin448.3S100B, VIM, MUC16, MUC1, CEACAM3, PSG2
17ascorbic acid44 249.2ALB, CHKB, HIF1A, TNFRSF11B, PIK3C2A, FGF2
18melphalan44 50 1110.2PIK3C2A, TNFSF10, MUC16, CHKB, TOP1
19actinomycin d448.2VIM, MUC1, TNFSF10, TOP1, VEGFA, HIF1A
20thyroxine44 249.1PIK3C2A, NPPB, FGF2, ALB, CEACAM3, CHKB
21genistein44 28 61 2 24 1113.0VEGFA, TNFRSF11B, HIF1A, VIM, NPPB, FGF2
22nitric oxide44 24 1110.0TNFSF10, CEACAM3, CHKB, MUC1, HIF1A, TNFRSF11B
23cyclosporin a44 28 6110.0PIK3C2A, CHKB, NPPB, HIF1A, TNFRSF11B, FGF2
24gold448.0TNFRSF11B, MUC16, PIK3C2A, CEACAM3, PSG2, MUC1
25tamoxifen44 50 28 1111.0CHKB, CEACAM3, MUC1, HIF1A, TNFRSF11B, TNFSF10
26hyaluronic acid44 248.9MUC16, FGF2, ALB, MUC1, VEGFA, VIM
27prednisolone44 28 119.8TNFRSF11B, MUC16, CHKB, ALB, NPPB, FGF2
28cysteine447.7NPPB, ALB, S100B, VIM, TNFRSF11B, HIF1A
29h2o2447.7ADA, FGF2, CHKB, HIF1A, TNFSF10, VIM
30atp44 288.6CHKB, VIM, ADA, S100B, TNFSF10, PIK3C2A
31aspartate447.6PIK3C2A, VIM, TNFRSF11B, CHKB, CEACAM3, S100B
32paclitaxel44 50 119.4VEGFA, TNFSF10, VIM, MUC16, ADA, TOP1
33estradiol44 24 119.4NPPB, VIM, MUC16, MUC1, CHKB, ALB
34alanine447.3CEACAM3, ADA, HIF1A, VIM, CHKB, ALB
35heparin44 28 24 1110.3NPPB, VEGFA, TNFRSF11B, VIM, TOP1, CHKB
36lipid447.3TNFRSF11B, PSG2, NPPB, S100B, ALB, ACADVL
37methotrexate50 44 119.1MUC1, PIK3C2A, TNFSF10, TNFRSF11B, HIF1A, VIM
38paraffin447.0VEGFA, HIF1A, FGF2, VIM, MUC16, MUC1
39progesterone44 28 61 24 1111.0CEACAM3, PIK3C2A, NPPB, S100B, TNFSF10, MUC1
40iron44 248.0VIM, TNFSF10, TNFRSF11B, ALB, PIK3C2A, NPPB
41steroid446.8CHKB, NPPB, S100B, CEACAM3, MUC16, TNFRSF11B
42dexamethasone44 50 28 119.7TNFRSF11B, HIF1A, VIM, MUC16, MUC1, ADA
43lactate446.5NPPB, S100B, PIK3C2A, HIF1A, VIM, MUC16
44testosterone44 61 24 119.5ALB, TNFSF10, TNFRSF11B, HIF1A, VIM, MUC16
45tyrosine446.2MUC16, HIF1A, MUC1, CEACAM3, S100B, NPPB
46estrogen446.1S100B, CEACAM3, CHKB, ADA, MUC1, MUC16
47doxorubicin44 50 118.1VEGFA, PIK3C2A, TNFSF10, TNFRSF11B, NPPB, PSG2
48creatinine446.1NPPB, S100B, PIK3C2A, TNFRSF11B, VIM, MUC16
49glucose446.0PIK3C2A, TNFSF10, TNFRSF11B, HIF1A, MUC16, MUC1
50vegf445.3CEACAM3, CHKB, ADA, MUC1, MUC16, VIM

GO Terms for genes affiliated with Pericardial Effusion

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Cellular components related to Pericardial Effusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.5VEGFA, TNFSF10, TNFRSF11B, PSG2, ALB, S100B
2extracellular vesicular exosomeGO:0700627.4TNFSF10, VIM, MUC16, MUC1, ALB, PIK3C2A
3extracellular spaceGO:0056156.9FGF2, VEGFA, TNFSF10, TNFRSF11B, MUC16, ADA

Biological processes related to Pericardial Effusion according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of thymocyte apoptotic processGO:07024410.1ADA, HIF1A
2positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614199.9HIF1A, VEGFA
3dopaminergic neuron differentiationGO:0715429.8VEGFA, HIF1A
4cell migration involved in sprouting angiogenesisGO:0020429.8FGF2, VEGFA
5positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:0309499.7HIF1A, VEGFA
6positive regulation of blood vessel endothelial cell migrationGO:0435369.6VEGFA, FGF2
7cellular response to hypoxiaGO:0714569.6VEGFA, HIF1A, S100B
8positive regulation of endothelial cell proliferationGO:0019389.6FGF2, HIF1A, VEGFA
9positive regulation of angiogenesisGO:0457669.5FGF2, HIF1A, VEGFA
10response to hypoxiaGO:0016669.5ADA, HIF1A, VEGFA
11positive regulation of neuroblast proliferationGO:0020529.4HIF1A, VEGFA

Molecular functions related to Pericardial Effusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:0420569.7FGF2, VEGFA
2cytokine activityGO:0051258.9FGF2, TNFRSF11B, TNFSF10, VEGFA
3protein bindingGO:0055155.9VEGFA, TNFSF10, HIF1A, VIM, MUC16, MUC1

Products for genes affiliated with Pericardial Effusion

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Sources for Pericardial Effusion

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet