MCID: PRC012
MIFTS: 58

Pericardial Effusion malady

Cardiovascular diseases category
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Summaries for Pericardial Effusion

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A pericardium disease that is characterized by an abnormal accumulation of fluid in the pericardial cavity.

MalaCards: Pericardial Effusion is related to pericarditis and constrictive pericarditis. An important gene associated with Pericardial Effusion is ADA (adenosine deaminase), and among its related pathways are Transcription Ligand dependent activation of the ESR1 SP pathway and Angiogenesis. The compounds nitroglycerin and mucicarmine have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and breast, and related mouse phenotypes are skeleton and cardiovascular system.

Wikipedia:65 Pericardial effusion (\"fluid around the heart\") is an abnormal accumulation of fluid in the... more...

Aliases & Classifications for Pericardial Effusion

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 35MeSH, 58SNOMED-CT, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

pericardial effusion 8 10 45 62


External Ids:

Disease Ontology8 DOID:118
MeSH35 D010490
SNOMED-CT58 373945007, 70370001
NCIt40 C3319
ICD1025 I31.3

Related Diseases for Pericardial Effusion

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17GeneCards, 18GeneDecks
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Diseases related to Pericardial Effusion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 345)
idRelated DiseaseScoreTop Affiliating Genes
1pericarditis31.4PSG2, ADA
2constrictive pericarditis30.9ADA, NPPB
3myocardial infarction30.7PIK3C2A, HIF1A, CHKB, NPPB
4dysphagia30.6PIK3C2A
5rheumatoid arthritis30.6VEGFA, TNFRSF11B, ADA, TOP1, CHKB
6peritonitis30.5MUC16, ADA, ALB
7lung cancer30.5VEGFA, TNFSF10, HIF1A, MUC16, TOP1, PSG2
8sarcoma30.4S100B, TOP1, ADA, MUC1, VIM
9adenocarcinoma30.3VEGFA, TNFSF10, HIF1A, VIM, MUC16, MUC1
10legionnaires' disease30.3PIK3C2A
11bronchogenic cyst30.3MUC16
12cardiac rupture30.3CHKB
13atrioventricular block30.2NPPB, PIK3C2A
14dilated cardiomyopathy30.2NPPB, CHKB, PIK3C2A
15acute myocardial infarction30.2PIK3C2A, CHKB, NPPB
16dermatomyositis30.2PIK3C2A, MUC16, MUC1, CHKB
17fibroma30.2VIM, MUC16
18synovial sarcoma30.1VIM, MUC1, S100B
19cervical cancer30.1TNFSF10, HIF1A, MUC16, PSG2
20leiomyosarcoma30.1VIM, MUC16, MUC1, S100B
21adenoid cystic carcinoma30.1VIM, MUC1, CEACAM3, S100B
22malignant mesothelioma30.0TNFSF10, VIM, MUC16, MUC1, CEACAM3, FGF2
23ischemia29.9PIK3C2A, VEGFA, TNFRSF11B, HIF1A, CHKB, NPPB
24lung adenocarcinoma29.9VEGFA, TNFSF10, HIF1A, MUC16, MUC1, TOP1
25hepatocellular carcinoma29.8VEGFA, TNFSF10, HIF1A, CEACAM3, PSG2, ALB
26melanoma29.8S100B, PSG2, CEACAM3, CHKB, TOP1, ADA
27breast cancer29.6MUC16, HIF1A, TNFRSF11B, TNFSF10, VEGFA, MUC1
28cardiac tamponade10.9
29hypothyroidism10.7
30mediastinitis10.5
31arthritis10.5
32leukemia10.5
33endomyocardial fibrosis10.5
34erdheim-chester disease10.5
35systemic lupus erythematosus10.5
36angiosarcoma10.5
37lupus erythematosus10.5
38down syndrome10.4
39hypertension10.4
40pericardial mesothelioma10.4
41esophagitis10.4
42myocarditis10.4
43cardiac diverticulum10.4
44aneurysm10.4
45myxedema10.3
46hemopericardium10.3
47mixed connective tissue disease10.3
48influenza10.3
49tuberculosis10.3
50ventricular septal defect10.3

Graphical network of the top 20 diseases related to Pericardial Effusion:



Diseases related to pericardial effusion

Symptoms for Pericardial Effusion

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Drugs & Therapeutics for Pericardial Effusion

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Pericardial Effusion

Search NIH Clinical Center for Pericardial Effusion

Genetic Tests for Pericardial Effusion

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Anatomical Context for Pericardial Effusion

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33MalaCards
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MalaCards organs/tissues related to Pericardial Effusion:

33
Heart, Lung, Breast, Endothelial, Kidney, Myeloid, T cells, Testes, Prostate, Bone, Salivary gland, Thyroid, Liver, Spinal cord, Brain, Whole blood, Pituitary

Animal Models for Pericardial Effusion or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Pericardial Effusion:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.3VEGFA, TNFSF10, TNFRSF11B, HIF1A, ADA, CHKB
2MP:00053858.2TNFRSF11B, HIF1A, VIM, ACADVL, NPPB, FGF2
3MP:00053708.1VEGFA, TNFSF10, HIF1A, MUC1, ADA, ACADVL
4MP:00020068.1VEGFA, TNFSF10, HIF1A, MUC1, ACADVL, ALB
5MP:00053698.0FGF2, VEGFA, HIF1A, VIM, CHKB, ACADVL
6MP:00053847.4VEGFA, TNFRSF11B, HIF1A, VIM, ADA, ACADVL
7MP:00053977.3PIK3C2A, VEGFA, TNFSF10, TNFRSF11B, HIF1A, VIM
8MP:00053766.7PIK3C2A, VEGFA, TNFSF10, HIF1A, VIM, MUC1
9MP:00107686.6PIK3C2A, VEGFA, TNFSF10, TNFRSF11B, HIF1A, VIM

Publications for Pericardial Effusion

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52PubMed
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Articles related to Pericardial Effusion:

(show top 50)    (show all 554)
idTitleAuthorsYear
1
Malignant pericardial effusion: still a long way to Ithaca? (23615155)
2013
2
Pulmonary hypertension complicated by pericardial effusion: a single center experience. (23258502)
2013
3
Thoracoscopic pericardial window fora88management of pericardial effusion in 15 dogs. (24106985)
2013
4
Erdheim-Chester Disease With Prominent Pericardial Effusion: Cytologic Findings and Review of the Literature. (23447119)
2013
5
Coexistence of cardiomyopathy and pericardial effusion : A challenging diagnosis. (24154881)
2013
6
Incidence and predictors of pericardial effusion after permanent heart rhythm device implantation: prospective evaluation of 968 consecutive patients. (23269085)
2013
7
A massive occult pericardial effusion in an athletic young male. (23720597)
2013
8
Motion artifacts on coronary CT angiography images in patients with a pericardial effusion. (24238642)
2013
9
Long-term course of stemi complicated by a moderate to severe pericardial effusion. Frequency of left ventricular pseudoaneurysm. (22078975)
2012
10
Recurrent pericardial effusion caused by pacemaker lead perforation and warfarin therapy at seven years after implantation. (22266846)
2012
11
Prognostic relevance of pericardial effusion in patients with malignant diseases. (23071482)
2012
12
The use of posterior pericardiotomy technique to prevent postoperative pericardial effusion in cardiac surgery. (22543342)
2012
13
Cytokines in pericardial effusion of patients with inflammatory pericardial disease. (22577248)
2012
14
Pericardial effusion and the unsuspected culprit. (23174740)
2012
15
Letter by Kern regarding article, "High-pressure loculated pericardial effusion in postpericardiotomy syndrome". (23213000)
2012
16
Infantile cardiac haemangioma with large pericardial effusion diagnosed during acute bronchiolitis episode. (22250834)
2012
17
Massive pericardial effusion and multiple pericardial masses due to an anterior mediastinal teratoma rupturing in pericardial sac. (23087278)
2012
18
Quantification of echodensities in tuberculous pericardial effusion using fractal geometry: a proof of concept study. (22838492)
2012
19
The N-terminal pro-B-type natriuretic peptide as a predictor of disease progression in patients with pericardial effusion. (21194766)
2012
20
Pericardial effusion as a crucial presentation of Erdheim-Chester disease in a hemodialysis patient: an overlooked diagnosis. (22732342)
2012
21
Anuric acute renal failure associated with pericardial effusion without signs of cardiac tamponade. (22880811)
2012
22
Morgagni hernia with massive pericardial effusion diagnosed in the second trimester: prenatal diagnosis and perinatal management. (20714116)
2011
23
Percutaneous balloon pericardiotomy for recurrent malignant pericardial effusion. (22088990)
2011
24
False-positive pericardial effusion due to breast attenuation on equilibrium radionuclide angiocardiography. (21565955)
2011
25
A rare case of situs inversus with dextrocardia, lutembacher syndrome, and pericardial effusion. (22567197)
2011
26
Ask the doctor. My doctor told me I have pericardial effusion. I know it has something to do with fluid in the heart. Can you tell me more? (21695862)
2011
27
Emergency ultrasound identification of loculated pericardial effusion: the importance of multiple cardiac views. (20148767)
2011
28
Case report: Percutaneous balloon pericardiotomy using Inoue balloon for patients with massive pericardial effusion. (18778860)
2010
29
Echocardiography of isolated subacute left heart tamponade in a patient with cor pulmonale and circumferential pericardial effusion. (20630052)
2010
30
Hashitoxicosis with pericardial effusion. (19403186)
2010
31
Cytologic aspects of T-cell acute lymphoblastic leukemia presenting as a massive pericardial effusion: a case report. (19534280)
2009
32
Re: Pericardial effusion impending tamponade: a look beyond Beck's triad. (19497471)
2009
33
Pericardial effusion and developing tamponade in a 30-year-old man. (18717255)
2008
34
Cardiac rupture or pericardial effusion? (17692412)
2008
35
Pericardial effusion as the only manifestation of infection with Francisella tularensis: a case report. (18554395)
2008
36
Prognosis of large, symptomatic pericardial effusion treated by echo-guided percutaneous pericardiocentesis. (19006110)
2008
37
Emergency department echocardiography demonstrates large pericardial effusion and pendulous cardiac motion in patient with shortness of breath and electrical alternans. (19086327)
2008
38
Large pericardial effusion requiring pericardiocentesis as cardinal sign of macrophage activation syndrome in systemic onset-juvenile idiopathic arthritis. (17160383)
2007
39
Pericardial effusion associated with an appropriately placed umbilical venous catheter. (17453042)
2007
40
Pericardial effusion due to hypothyroidism in Down syndrome: report of four cases. (17435671)
2007
41
Correct diagnosis and successful treatment for pericardial effusion due to toothpick injury: a case report and literature review. (17696263)
2007
42
Pleural and pericardial effusion: a potential ultrasonographic marker for the prenatal differential diagnosis between congenital diaphragmatic eventration and congenital diaphragmatic hernia. (17366518)
2007
43
Etiological diagnosis of pericardial effusion. (17661668)
2006
44
Characterization of IL-2-activated TILs and their use in intrapericardial immunotherapy in malignant pericardial effusion. (16362409)
2006
45
Cardiac diverticulum with pericardial effusion: report of two new cases treated by in-utero pericardiocentesis and a review of the literature. (15747327)
2005
46
Solitary fibrous tumor of the pericardium presenting itself as a pericardial effusion and right ventricular obstruction. (15365524)
2004
47
Methysergide-induced retroperitoneal fibrosis and pericardial effusion. (15151680)
2004
48
Pericardial effusion and cardiomyopathy following arthritis with parvovirus B19 infection: response to intravenous immunoglobulin. (17039168)
2001
49
An adult case of mixed connective tissue disease associated with perimyocarditis and massive pericardial effusion. (3723788)
1986
50
Endomyocardial fibrosis presenting as chronic pericardial effusion. (5678613)
1968

Variations for Pericardial Effusion

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Expression for genes affiliated with Pericardial Effusion

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pericardial Effusion

Search GEO for disease gene expression data for Pericardial Effusion.

Pathways for genes affiliated with Pericardial Effusion

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50PathCards, 60Thomson Reuters, 5Cell Signaling Technology, 38NCBI BioSystems Database, 51PharmGKB, 57SinoBiological
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Pathways related to Pericardial Effusion according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
9.5VEGFA, HIF1A, ADA
2
Show member pathways
Angiogenesis38
9.4FGF2, HIF1A, VEGFA
3
Show member pathways
9.1FGF2, VEGFA, PIK3C2A
49.1FGF2, VEGFA, PIK3C2A

Compounds for genes affiliated with Pericardial Effusion

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45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 24HMDB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Pericardial Effusion according to GeneCards/GeneDecks:

(show top 50)    (show all 226)
idCompoundScoreTop Affiliating Genes
1nitroglycerin45 1110.1NPPB, CHKB, HIF1A, TNFRSF11B, PIK3C2A
2mucicarmine458.9VIM, S100B, CEACAM3, MUC1
3trastuzumab45 51 1110.9VEGFA, TNFSF10, MUC1, NPPB, HIF1A
4dihydrotestosterone45 29 24 1111.8FGF2, HIF1A, TNFRSF11B, VIM, MUC1, CHKB
5vincristine45 51 1110.7ADA, TNFSF10, HIF1A, VIM, TOP1, NPPB
6celecoxib45 61 29 51 24 1113.5HIF1A, VEGFA, FGF2, ALB, TNFSF10, TNFRSF11B
7topotecan45 119.5HIF1A, TNFSF10, VEGFA, TOP1, MUC16
8gefitinib45 51 1110.5FGF2, TOP1, VIM, TNFSF10, VEGFA, ALB
9adriamycin458.5VIM, HIF1A, CEACAM3, TOP1, MUC1, TNFSF10
10thymidine45 249.4PSG2, CEACAM3, MUC1, CHKB, HIF1A, NPPB
11glycogen45 249.4VIM, CHKB, PSG2, S100B, PIK3C2A, MUC1
12b 723458.4S100B, CEACAM3, PSG2, MUC1, MUC16, VIM
135fluorouracil458.4VEGFA, TOP1, TNFSF10, CEACAM3, MUC1, HIF1A
14irinotecan45 51 1110.4TNFSF10, ALB, VEGFA, HIF1A, TOP1, CEACAM3
15sb 20358045 619.3FGF2, NPPB, VEGFA, TNFSF10, TNFRSF11B, HIF1A
16hematoxylin458.3S100B, VIM, MUC16, MUC1, CEACAM3, PSG2
17ascorbic acid45 249.2ALB, CHKB, HIF1A, TNFRSF11B, PIK3C2A, FGF2
18melphalan45 51 1110.2PIK3C2A, TNFSF10, MUC16, CHKB, TOP1
19actinomycin d458.2VIM, MUC1, TNFSF10, TOP1, VEGFA, HIF1A
20thyroxine45 249.1PIK3C2A, NPPB, FGF2, ALB, CEACAM3, CHKB
21genistein45 29 61 3 24 1113.0VEGFA, TNFRSF11B, HIF1A, VIM, NPPB, FGF2
22nitric oxide45 24 1110.0TNFSF10, CEACAM3, CHKB, MUC1, HIF1A, TNFRSF11B
23cyclosporin a45 29 6110.0PIK3C2A, CHKB, NPPB, HIF1A, TNFRSF11B, FGF2
24gold458.0TNFRSF11B, MUC16, PIK3C2A, CEACAM3, PSG2, MUC1
25tamoxifen45 51 29 1111.0CHKB, CEACAM3, MUC1, HIF1A, TNFRSF11B, TNFSF10
26hyaluronic acid45 248.9MUC16, FGF2, ALB, MUC1, VEGFA, VIM
27prednisolone45 29 119.8TNFRSF11B, MUC16, CHKB, ALB, NPPB, FGF2
28cysteine457.7NPPB, ALB, S100B, VIM, TNFRSF11B, HIF1A
29h2o2457.7ADA, FGF2, CHKB, HIF1A, TNFSF10, VIM
30atp45 298.6CHKB, VIM, ADA, S100B, TNFSF10, PIK3C2A
31aspartate457.6PIK3C2A, VIM, TNFRSF11B, CHKB, CEACAM3, S100B
32paclitaxel45 51 119.4VEGFA, TNFSF10, VIM, MUC16, ADA, TOP1
33estradiol45 24 119.4NPPB, VIM, MUC16, MUC1, CHKB, ALB
34alanine457.3CEACAM3, ADA, HIF1A, VIM, CHKB, ALB
35heparin45 29 24 1110.3NPPB, VEGFA, TNFRSF11B, VIM, TOP1, CHKB
36lipid457.3TNFRSF11B, PSG2, NPPB, S100B, ALB, ACADVL
37methotrexate51 45 119.1MUC1, PIK3C2A, TNFSF10, TNFRSF11B, HIF1A, VIM
38paraffin457.0VEGFA, HIF1A, FGF2, VIM, MUC16, MUC1
39progesterone45 29 61 24 1111.0CEACAM3, PIK3C2A, NPPB, S100B, TNFSF10, MUC1
40iron45 248.0VIM, TNFSF10, TNFRSF11B, ALB, PIK3C2A, NPPB
41steroid456.8CHKB, NPPB, S100B, CEACAM3, MUC16, TNFRSF11B
42dexamethasone45 51 29 119.7TNFRSF11B, HIF1A, VIM, MUC16, MUC1, ADA
43lactate456.5NPPB, S100B, PIK3C2A, HIF1A, VIM, MUC16
44testosterone45 61 24 119.5ALB, TNFSF10, TNFRSF11B, HIF1A, VIM, MUC16
45tyrosine456.2MUC16, HIF1A, MUC1, CEACAM3, S100B, NPPB
46estrogen456.1S100B, CEACAM3, CHKB, ADA, MUC1, MUC16
47doxorubicin45 51 118.1VEGFA, PIK3C2A, TNFSF10, TNFRSF11B, NPPB, PSG2
48creatinine456.1NPPB, S100B, PIK3C2A, TNFRSF11B, VIM, MUC16
49glucose456.0PIK3C2A, TNFSF10, TNFRSF11B, HIF1A, MUC16, MUC1
50vegf455.3CEACAM3, CHKB, ADA, MUC1, MUC16, VIM

GO Terms for genes affiliated with Pericardial Effusion

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16Gene Ontology
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Cellular components related to Pericardial Effusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.5VEGFA, TNFSF10, TNFRSF11B, PSG2, ALB, S100B
2extracellular vesicular exosomeGO:0700627.4TNFSF10, VIM, MUC16, MUC1, ALB, PIK3C2A
3extracellular spaceGO:0056156.9FGF2, VEGFA, TNFSF10, TNFRSF11B, MUC16, ADA

Biological processes related to Pericardial Effusion according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of thymocyte apoptotic processGO:07024410.1ADA, HIF1A
2positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614199.9HIF1A, VEGFA
3dopaminergic neuron differentiationGO:0715429.8VEGFA, HIF1A
4cell migration involved in sprouting angiogenesisGO:0020429.8FGF2, VEGFA
5positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:0309499.7HIF1A, VEGFA
6positive regulation of blood vessel endothelial cell migrationGO:0435369.6VEGFA, FGF2
7cellular response to hypoxiaGO:0714569.6VEGFA, HIF1A, S100B
8positive regulation of endothelial cell proliferationGO:0019389.6FGF2, HIF1A, VEGFA
9positive regulation of angiogenesisGO:0457669.5FGF2, HIF1A, VEGFA
10response to hypoxiaGO:0016669.5ADA, HIF1A, VEGFA
11positive regulation of neuroblast proliferationGO:0020529.4HIF1A, VEGFA

Molecular functions related to Pericardial Effusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:0420569.7FGF2, VEGFA
2cytokine activityGO:0051258.9FGF2, TNFRSF11B, TNFSF10, VEGFA
3protein bindingGO:0055155.9VEGFA, TNFSF10, HIF1A, VIM, MUC16, MUC1

Products for genes affiliated with Pericardial Effusion

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Sources for Pericardial Effusion

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet