Pericardial Effusion malady

Wikipedia: Pericardial effusion (\"fluid around the heart\") is an abnormal accumulation of fluid in the...⁴⁴ more...

MalaCards: Pericardial Effusion is related to cardiac tamponade and pericarditis. An important gene associated with Pericardial Effusion is ACADVL (acyl-CoA dehydrogenase, very long chain). The compounds vincristine and sialic acid have been mentioned in the context of this disorder. Affiliated tissues include heart and endothelial.

Disease Ontology: A heart disease that is characterized by an abnormal accumulation of fluid in the pericardial cavity.⁶

Aliases & Descriptions:

pericardial effusion 6 8 32 43

Diseases related to pericardial effusion by text searches and GeneDecks gene sharing:

(show top 50)    (show all 356)

id	Related Disease	Score	Top Affiliating Genes
1	cardiac tamponade	31.5	PSG2, ADA
2	pericarditis	29.6	PIK3C2A, CEACAM3, ALB, TNNI3, PSG2, ADA
3	hypothyroidism	28.3	PIK3C2A, CHKB, CEACAM3, ALB, PSG2, ADA
4	hypoxia	26.2	PIK3C2A, CHKB, MUC1, S100B, ALB, HIF1A
5	tuberculous peritonitis	13.5	MUC16, ADA
6	aseptic meningitis	13.5	CHKB, ADA
7	pleural tuberculosis	13.5	PSG2, ADA
8	creatine phosphokinase, elevated serum	13.5	PIK3C2A, CHKB
9	gas gangrene	13.4	PIK3C2A, CHKB
10	adult dermatomyositis	13.4	PIK3C2A, CHKB
11	mucinous ovarian cystadenoma	13.4	MUC16, PSG2
12	bronchogenic cyst	13.4	MUC16, CEACAM3
13	myxedema	13.3	CHKB, MUC16
14	rhabdomyolysis, cerivastatin-induced	13.3	PIK3C2A, CHKB, ACADVL
15	abdominal tuberculosis	13.3	ALB, ADA
16	ectopic pregnancy	13.3	PIK3C2A, CHKB
17	intermediate coronary syndrome	13.3	PIK3C2A, TNNI3
18	ovarian cyst	13.2	MUC16, CEACAM3
19	status asthmaticus	13.2	PIK3C2A, CHKB
20	constrictive pericarditis	13.2	ALB, ADA
21	acute kidney tubular necrosis	13.2	PIK3C2A, ALB
22	bronchiolitis obliterans organizing pneumonia	13.2	PIK3C2A, ALB
23	viral pneumonia	13.2	CHKB, ALB
24	papillary adenocarcinoma	13.2	MUC1, MUC16
25	protein-losing enteropathy	13.1	MUC16, ALB
26	congestive heart failure	13.1	PIK3C2A, CHKB, MUC16
27	duchenne muscular dystrophy	13.1	PIK3C2A, CHKB, TNNI3
28	idiopathic myopathy	13.1	PIK3C2A, CHKB, TNNI3
29	calciphylaxis	13.1	PIK3C2A, ALB
30	fibrous meningioma	13.1	MUC1, S100B
31	intraneural perineurioma	13.1	MUC1, S100B
32	cutaneous paget's disease	13.1	MUC1, CEACAM3
33	syncope	13.1	PIK3C2A, CHKB, TNNI3
34	anaplastic ependymoma	13.1	MUC1, S100B
35	choroid plexus papilloma	13.1	MUC1, S100B
36	pulmonary arteriovenous malformation	13.1	ALB, HIF1A
37	osseous dysplasia	13.1	ALB, ADA
38	transitional meningioma	13.1	MUC1, HIF1A
39	miliary tuberculosis	13.0	MUC16, ALB, ADA
40	middle ear cholesteatoma	13.0	CHKB, HIF1A
41	legionnaires' disease	13.0	PIK3C2A, ALB, ADA
42	pancreatic diseases	13.0	MUC1, PSG2, ADA
43	compartment syndrome	13.0	PIK3C2A, CHKB, ALB
44	dermatofibrosarcoma protuberans	13.0	VIM, ADA
45	hypocalcemia	13.0	PIK3C2A, CHKB, ALB
46	fibromyalgia	13.0	CHKB, ALB, ADA
47	obstructive jaundice	13.0	MUC16, ALB, PSG2
48	pulmonary edema	13.0	PIK3C2A, ALB, ADA
49	cramps	12.9	PIK3C2A, ALB, ADA
50	hyperuricemia	12.9	PIK3C2A, ALB, ADA

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to pericardial effusion:

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Articles related to pericardial effusion:

(show all 17)

id	Title	Authors	Year	Affiliating Genes
1	Preliminary investigation of the clinical value of va scular endothelial growth factor and hypoxia-inducible factor-1alpha in pericar dial fluid in diagnosing malignant and tuberculous pericardial effusion. (20424452)	Liu J.... Liu Q.	2010	ADA, HIF1A
2	Differentiation of malignant from nonmalignant, infl ammatory pericardial effusions with biomarkers (20024642)	Karatolios K.... Maisch B.	2009	PSG2
3	Adenosine deaminase in the diagnosis of tuberculous pericardial effusion. (18344697)	Arroyo M.... Soberman J.E.	2008	ADA
4	Rhabdomyolysis, renal failure, pericardial effusion, and acquired von Willebrand disease resulting from hypothyroidism in a 10-year-old girl. (18341381)	Galli-Tsinopoulou A.... Nousia-Arvanitakis S.	2008	PIK3C2A
5	The role of histopathology in establishing the diagnosis of tuberculous pericardial effusions in the presence of HIV. (16430476)	Reuter H.... Doubell A.F.	2006	ADA
6	Clinical factors associated with persistent pericardial effusion after successful primary coronary angioplasty. (16100170)	Sugiura T.... Iwasaka T.	2005	CHKB
7	Video-assisted thoracoscopic pericardial fenestration for tuberculous pericardial effusion. (14997974)	Kameyama K.... Yokomise H.	2004	ADA
8	Cardiomyopathy and pericardial effusion in infancy point to a fatty acid b-oxidation defect after exclusion of an underlying infection. (12457256)	Spiekerkoetter U.... Wendel U.	2003	ACADVL
9	A case of tuberculous pericarditis, the diagnosis of which was complicated by the delay in the rise of adenosine deaminase in the pericardial effusion (12806984)	Yano S.... Saito S.	2003	ADA
10	The usefulness of a panel of immunostains in the diagnosis and differentiation of metastatic malignancies in pericardial effusions. (11014658)	Gupta R.K.... Naran S.	2000	S100B, VIM, MUC1
11	New scoring system using tumor markers in diagnosing patients with moderate pericardial effusions. (9292326)	Koh K.K.... Lee Y.H.	1997	ADA
12	The value of measuring adenosine deaminase activity in pericardial effusion fluid for diagnosing the etiology of pericardial effusion (9181887)	FijaA8kowska A.... Kwiek S.	1996	ADA
13	A case of the yellow nail syndrome associated with massive chylous ascites, pleural and pericardial effusions. (8956479)	Malek N.P.... Manns M.P.	1996	ALB
14	Massive pericardial effusion in scleroderma: a review of five cases. (7633799)	Satoh M.... Homma M.	1995	TOP1
15	Adenosine deaminase and carcinoembryonic antigen in pericardial effusion diagnosis, especially in suspected tuberculous pericarditis. (8205688)	Koh K.K.... Kim J.M.	1994	ADA, CEACAM3
16	Usefulness of serum CA125 measurement for monitoring pericardial effusion. (8340995)	Seo T.... Kobayashi K.	1993	MUC16
17	Serum CA125 measurement is useful in 3 cases with pericardial effusion (8516579)	Toshihiko S.... Mitsuko H.	1993	MUC16

Genes related to pericardial effusion according to GeneCards:

(show all 15)

id	Symbol	Description	Score	GeneCards Section Context
1	ACADVL	acyl-CoA dehydrogenase, very long chain	11.0	Publications
2	ADA	adenosine deaminase	11.0	Publications
3	PSG2	pregnancy specific beta-1-glycoprotein 2	11.0	Publications
4	CHKB	choline kinase beta	11.0	Publications
5	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.0	Publications
6	MUC16	mucin 16, cell surface associated	11.0	Publications
7	ALG9	asparagine-linked glycosylation 9, alpha-1,2-mannosyltransferase homolog (S. cerevisiae)	11.0
8	TNNI3	troponin I type 3 (cardiac)	11.0
9	CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	11.0	Publications
10	S100B	S100 calcium binding protein B	11.0	Publications
11	TOP1	topoisomerase (DNA) I	11.0	Publications
12	VIM	vimentin	11.0	Publications
13	MUC1	mucin 1, cell surface associated	11.0	Publications
14	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11.0	Publications
15	ALB	albumin	11.0	Publications

Compounds related to pericardial effusion according to GeneDecks:

(show top 50)    (show all 105)

id	Compound	Score	Top Affiliating Genes
1	vincristine32 34 9 9	13.4	ADA
2	sialic acid32	10.2	PSG2, S100B
3	halothane32 9 9	12.1	PIK3C2A, ALB
4	ascorbic acid32 18	11.1	S100B, CHKB
5	glucose32	9.9	MUC16, S100B, PSG2
6	h2o232	9.9	MUC16, ADA
7	polyethylene glycol32	9.9	MUC1, CHKB
8	indium32	9.6	PSG2, MUC1, CEACAM3
9	melphalan32 9 9	11.5	MUC16, TOP1, PIK3C2A, CHKB
10	metronidazole32 9 9	11.5	CEACAM3, MUC1, PSG2
11	progesterone32 42 9 18 9	13.5	MUC16, CEACAM3, S100B
12	pyruvate32	9.5	PIK3C2A, CHKB, HIF1A
13	estradiol32 9 18 9	12.4	VIM, CHKB, MUC1
14	bicarbonate32	9.4	CHKB, PIK3C2A, ALB, MUC16
15	colchicine32 9 9	11.4	PIK3C2A, S100B, CHKB, VIM
16	eosin32	9.3	MUC1, VIM, S100B
17	s 10032	9.3	S100B, VIM, MUC1
18	reticulin32	9.3	MUC1, VIM, S100B
19	dtpa32	9.2	ALB, CEACAM3, MUC1
20	catecholamine32	9.2	CHKB, VIM, PIK3C2A, S100B
21	heparin32 9 18 9	12.2	ALB, CHKB, VIM, PIK3C2A
22	fibrinogen32	9.1	CHKB, PIK3C2A, CEACAM3, ALB
23	gold32	9.0	MUC16, PSG2, MUC1, PIK3C2A, CEACAM3
24	estrogen32	9.0	HIF1A, CHKB, CEACAM3, S100B
25	mucicarmine32	9.0	MUC1, VIM, S100B, CEACAM3
26	agar32	8.8	HIF1A, MUC1, VIM
27	cytarabine32 34 9 9	11.8	VIM, MUC1, ADA, TOP1
28	prednisolone32 9 9	10.8	CHKB, ALB, PIK3C2A, MUC16
29	formaldehyde32 18	9.6	VIM, MUC1, S100B, TOP1, PSG2
30	aspartate32	8.6	S100B, VIM, PIK3C2A, CHKB, TOP1, CEACAM3
31	glycogen32 18	9.5	PSG2, VIM, PIK3C2A, S100B, CHKB, MUC1
32	b 72332	8.4	VIM, MUC1, MUC16, S100B, CEACAM3, PSG2
33	hematoxylin32	8.4	PSG2, CEACAM3, MUC1, MUC16, S100B, VIM
34	mannitol32 9 9	10.4	ALB, CHKB, S100B, HIF1A
35	5fluorouracil32	8.3	HIF1A, TOP1, PSG2, CEACAM3, MUC1
36	creatinine32	8.1	MUC16, ADA, PSG2, ACADVL, TNNI3, CEACAM3
37	paclitaxel32 34 9 9	11.1	S100B, HIF1A, TOP1, ADA, VIM, MUC16
38	tamoxifen32 34 9 9	11.1	CHKB, CEACAM3, HIF1A, MUC1, VIM
39	thymidine32 18	9.0	MUC1, S100B, CEACAM3, HIF1A, PSG2, CHKB
40	iron32 18	9.0	ALB, HIF1A, PIK3C2A, VIM, MUC16, S100B
41	adriamycin32	7.9	CEACAM3, HIF1A, MUC1, VIM, TOP1, PSG2
42	cysteine32	7.8	HIF1A, CHKB, MUC1, ALB, S100B
43	doxorubicin32 34 9 9	10.7	ADA, PSG2, MUC16, VIM, HIF1A, CEACAM3
44	dexamethasone32 42 34 9 9	11.6	HIF1A, VIM, MUC16, ADA, MUC1, CHKB
45	alanine32	7.4	CEACAM3, ALB, PIK3C2A, CHKB, VIM, S100B
46	paraffin32	7.3	PSG2, VIM, HIF1A, MUC1, MUC16, S100B
47	methotrexate32 34 42 9 9	11.3	VIM, PIK3C2A, MUC1, CEACAM3, HIF1A, ALB
48	testosterone32 9 18 9	10.1	CHKB, PIK3C2A, HIF1A, ALB, VIM, MUC1
49	vegf32	6.8	ADA, MUC1, PSG2, HIF1A, CEACAM3, S100B
50	lactate32	6.6	ADA, PSG2, TNNI3, ALB, CEACAM3, S100B