MCID: PRC012
MIFTS: 49

Pericardial Effusion malady

Cardiovascular diseases category

Aliases & Classifications for Pericardial Effusion

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 38NCIt, 33MeSH, 25ICD10
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Pericardial Effusion, Aliases & Descriptions:

Name: Pericardial Effusion 9 11 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology9 DOID:118
NCIt38 C3319
SNOMED-CT55 373945007, 70370001
MeSH33 D010490
ICD1025 I31.3

Summaries for Pericardial Effusion

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Disease Ontology:9 A pericardium disease that is characterized by an abnormal accumulation of fluid in the pericardial cavity.

MalaCards based summary: Pericardial Effusion is related to pericarditis and constrictive pericarditis. An important gene associated with Pericardial Effusion is ADA (adenosine deaminase), and among its related pathways are Transcription Ligand dependent activation of the ESR1 SP pathway and Angiogenesis. The compounds nitroglycerin and mucicarmine have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and breast, and related mouse phenotypes are skeleton and cardiovascular system.

Wikipedia:63 Pericardial effusion (\"fluid around the heart\") is an abnormal accumulation of fluid in the... more...

Related Diseases for Pericardial Effusion

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Diseases related to Pericardial Effusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 344)
idRelated DiseaseScoreTop Affiliating Genes
1pericarditis32.0ADA, PSG2
2constrictive pericarditis31.5NPPB, ADA
3dysphagia31.2PIK3C2A
4bronchogenic cyst31.0MUC16
5cardiac rupture31.0CHKB
6myocardial infarction30.9CHKB, HIF1A, PIK3C2A, NPPB
7peritonitis30.9ADA, MUC16, ALB
8atrioventricular block30.7NPPB, PIK3C2A
9dilated cardiomyopathy30.6NPPB, PIK3C2A, CHKB
10acute myocardial infarction30.6CHKB, NPPB, PIK3C2A
11kidney disease30.5TNFRSF11B, VEGFA
12dermatomyositis30.5PIK3C2A, MUC1, MUC16, CHKB
13rheumatoid arthritis30.4ADA, TOP1, VEGFA, TNFRSF11B, CHKB
14fibroma30.4MUC16, VIM
15sarcoma30.3S100B, MUC1, VIM, ADA, TOP1
16hemangioma30.3VEGFA, FGF2
17leiomyosarcoma30.2S100B, MUC1, VIM, MUC16
18mesothelioma30.1PSG2, CEACAM3, ADA, MUC16, TNFSF10, VIM
19pulmonary embolism30.1NPPB, ALB
20lung cancer30.0HIF1A, TNFSF10, MUC16, TOP1, PSG2, VEGFA
21ischemia29.3CHKB, PIK3C2A, VEGFA, TNFRSF11B, HIF1A, NPPB
22adenocarcinoma29.2TNFSF10, PSG2, CEACAM3, TOP1, ADA, MUC1
23hepatocellular carcinoma29.1HIF1A, FGF2, ALB, PSG2, CEACAM3, TNFSF10
24melanoma28.3ADA, TOP1, CHKB, PSG2, S100B, FGF2
25breast cancer28.1HIF1A, TNFRSF11B, TOP1, ADA, MUC1, MUC16
26cardiac tamponade10.9
27hypothyroidism10.7
28legionaire disease10.6PIK3C2A
29mediastinitis10.6
30gas gangrene10.5PIK3C2A
31leukemia10.5
32atrial fibrillation10.5
33transitional meningioma10.5MUC1
34hidradenoma10.5MUC1
35arthritis10.5
36neuroleptic malignant syndrome10.5CHKB, PIK3C2A
37status asthmaticus10.5PIK3C2A
38tuberculous peritonitis10.5MUC16, ADA
39ovarian serous cystadenocarcinoma10.5MUC16
40aseptic meningitis10.5CHKB, ADA
41pleural tuberculosis10.5ADA, PSG2
42creatine phosphokinase, elevated serum10.5PIK3C2A, CHKB
43systemic lupus erythematosus10.5
44endomyocardial fibrosis10.5
45erdheim-chester disease10.5
46down syndrome10.5
47angiosarcoma10.5
48lupus erythematosus10.5
49cardiogenic shock10.4NPPB, PIK3C2A
50aneurysm10.4

Graphical network of the top 20 diseases related to Pericardial Effusion:



Diseases related to pericardial effusion

Symptoms for Pericardial Effusion

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Drugs & Therapeutics for Pericardial Effusion

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Drug clinical trials:

Search ClinicalTrials for Pericardial Effusion

Search NIH Clinical Center for Pericardial Effusion

Genetic Tests for Pericardial Effusion

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Anatomical Context for Pericardial Effusion

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MalaCards organs/tissues related to Pericardial Effusion:

31
Heart, Lung, Breast, Kidney, Endothelial, Myeloid, T cells, B cells, Bone, Whole blood, Spinal cord, Liver, Thyroid, Salivary gland, Prostate, Testes, Pituitary

Animal Models for Pericardial Effusion or affiliated genes

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MGI Mouse Phenotypes related to Pericardial Effusion:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.3VEGFA, TNFSF10, TNFRSF11B, HIF1A, ADA, CHKB
2MP:00053858.2TNFRSF11B, HIF1A, VIM, ACADVL, NPPB, FGF2
3MP:00053708.1VEGFA, TNFSF10, HIF1A, MUC1, ADA, ACADVL
4MP:00020068.1VEGFA, TNFSF10, HIF1A, MUC1, ACADVL, ALB
5MP:00053698.0FGF2, VEGFA, HIF1A, VIM, CHKB, ACADVL
6MP:00053847.4VEGFA, TNFRSF11B, HIF1A, VIM, ADA, ACADVL
7MP:00053977.3PIK3C2A, VEGFA, TNFSF10, TNFRSF11B, HIF1A, VIM
8MP:00053766.7PIK3C2A, VEGFA, TNFSF10, HIF1A, VIM, MUC1
9MP:00107686.6PIK3C2A, VEGFA, TNFSF10, TNFRSF11B, HIF1A, VIM

Publications for Pericardial Effusion

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Articles related to Pericardial Effusion:

(show top 50)    (show all 599)
idTitleAuthorsYear
1
Pericardial effusion associated with hypothyroidism in an adult female with Down syndrome. (25851508)
2015
2
Compressive Mediastinal Mass and Large Pericardial Effusion in a Child. (25799035)
2015
3
Delayed recurrent pericarditis complicated by pericardial effusion and cardiac tamponade in a blunt trauma patient. (25709254)
2015
4
Pericardial effusion as the first manifestation of occupational tuberculosis in a health care worker. (25720029)
2014
5
A new strategy for pericardiocentesis with a visual puncture system: the feasibility and efficiency study in a pericardial effusion model. (25300658)
2014
6
Electrical alternans due to large bilateral pleural effusion without pericardial effusion. (25129296)
2014
7
Idiopathic pericarditis and pericardial effusion in children: contemporary epidemiology and management. (25380671)
2014
8
Central venous catheter-induced pericardial effusion in a neonate: a case study and recommendations for practice. (25391594)
2014
9
Malignant pericardial effusion: still a long way to Ithaca? (23615155)
2013
10
Pulmonary hypertension complicated by pericardial effusion: a single center experience. (23258502)
2013
11
Thoracoscopic pericardial window fora88management of pericardial effusion in 15 dogs. (24106985)
2013
12
Erdheim-Chester Disease With Prominent Pericardial Effusion: Cytologic Findings and Review of the Literature. (23447119)
2013
13
Coexistence of cardiomyopathy and pericardial effusion : A challenging diagnosis. (24154881)
2013
14
Incidence and predictors of pericardial effusion after permanent heart rhythm device implantation: prospective evaluation of 968 consecutive patients. (23269085)
2013
15
Long-term course of stemi complicated by a moderate to severe pericardial effusion. Frequency of left ventricular pseudoaneurysm. (22078975)
2012
16
Recurrent pericardial effusion caused by pacemaker lead perforation and warfarin therapy at seven years after implantation. (22266846)
2012
17
Prognostic relevance of pericardial effusion in patients with malignant diseases. (23071482)
2012
18
The use of posterior pericardiotomy technique to prevent postoperative pericardial effusion in cardiac surgery. (22543342)
2012
19
Cytokines in pericardial effusion of patients with inflammatory pericardial disease. (22577248)
2012
20
Pericardial effusion and the unsuspected culprit. (23174740)
2012
21
Letter by Kern regarding article, "High-pressure loculated pericardial effusion in postpericardiotomy syndrome". (23213000)
2012
22
Infantile cardiac haemangioma with large pericardial effusion diagnosed during acute bronchiolitis episode. (22250834)
2012
23
Massive pericardial effusion and multiple pericardial masses due to an anterior mediastinal teratoma rupturing in pericardial sac. (23087278)
2012
24
Quantification of echodensities in tuberculous pericardial effusion using fractal geometry: a proof of concept study. (22838492)
2012
25
The N-terminal pro-B-type natriuretic peptide as a predictor of disease progression in patients with pericardial effusion. (21194766)
2012
26
Morgagni hernia with massive pericardial effusion diagnosed in the second trimester: prenatal diagnosis and perinatal management. (20714116)
2011
27
Percutaneous balloon pericardiotomy for recurrent malignant pericardial effusion. (22088990)
2011
28
False-positive pericardial effusion due to breast attenuation on equilibrium radionuclide angiocardiography. (21565955)
2011
29
A rare case of situs inversus with dextrocardia, lutembacher syndrome, and pericardial effusion. (22567197)
2011
30
Case report: Percutaneous balloon pericardiotomy using Inoue balloon for patients with massive pericardial effusion. (18778860)
2010
31
Echocardiography of isolated subacute left heart tamponade in a patient with cor pulmonale and circumferential pericardial effusion. (20630052)
2010
32
Hashitoxicosis with pericardial effusion. (19403186)
2010
33
Cytologic aspects of T-cell acute lymphoblastic leukemia presenting as a massive pericardial effusion: a case report. (19534280)
2009
34
Re: Pericardial effusion impending tamponade: a look beyond Beck's triad. (19497471)
2009
35
Pericardial effusion and developing tamponade in a 30-year-old man. (18717255)
2008
36
Cardiac rupture or pericardial effusion? (17692412)
2008
37
Pericardial effusion as the only manifestation of infection with Francisella tularensis: a case report. (18554395)
2008
38
Prognosis of large, symptomatic pericardial effusion treated by echo-guided percutaneous pericardiocentesis. (19006110)
2008
39
Large pericardial effusion requiring pericardiocentesis as cardinal sign of macrophage activation syndrome in systemic onset-juvenile idiopathic arthritis. (17160383)
2007
40
Pericardial effusion associated with an appropriately placed umbilical venous catheter. (17453042)
2007
41
Pericardial effusion due to hypothyroidism in Down syndrome: report of four cases. (17435671)
2007
42
Correct diagnosis and successful treatment for pericardial effusion due to toothpick injury: a case report and literature review. (17696263)
2007
43
Pleural and pericardial effusion: a potential ultrasonographic marker for the prenatal differential diagnosis between congenital diaphragmatic eventration and congenital diaphragmatic hernia. (17366518)
2007
44
Etiological diagnosis of pericardial effusion. (17661668)
2006
45
Cardiac diverticulum with pericardial effusion: report of two new cases treated by in-utero pericardiocentesis and a review of the literature. (15747327)
2005
46
Solitary fibrous tumor of the pericardium presenting itself as a pericardial effusion and right ventricular obstruction. (15365524)
2004
47
Methysergide-induced retroperitoneal fibrosis and pericardial effusion. (15151680)
2004
48
Pericardial effusion and cardiomyopathy following arthritis with parvovirus B19 infection: response to intravenous immunoglobulin. (17039168)
2001
49
An adult case of mixed connective tissue disease associated with perimyocarditis and massive pericardial effusion. (3723788)
1986
50
Endomyocardial fibrosis presenting as chronic pericardial effusion. (5678613)
1968

Variations for Pericardial Effusion

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Expression for genes affiliated with Pericardial Effusion

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Search GEO for disease gene expression data for Pericardial Effusion.

Pathways for genes affiliated with Pericardial Effusion

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Pathways related to Pericardial Effusion according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway58
9.5VEGFA, HIF1A, ADA
2
Show member pathways
Angiogenesis36
9.4FGF2, HIF1A, VEGFA
3
Show member pathways
9.1FGF2, VEGFA, PIK3C2A
49.1FGF2, VEGFA, PIK3C2A

Compounds for genes affiliated with Pericardial Effusion

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Compounds related to Pericardial Effusion according to GeneCards Suite gene sharing:

(show top 50)    (show all 226)
idCompoundScoreTop Affiliating Genes
1nitroglycerin43 1210.1NPPB, CHKB, HIF1A, TNFRSF11B, PIK3C2A
2mucicarmine438.9VIM, S100B, CEACAM3, MUC1
3trastuzumab43 49 1210.9VEGFA, TNFSF10, MUC1, NPPB, HIF1A
4dihydrotestosterone43 28 24 1211.8FGF2, HIF1A, TNFRSF11B, VIM, MUC1, CHKB
5vincristine43 49 1210.7ADA, TNFSF10, HIF1A, VIM, TOP1, NPPB
6celecoxib43 59 28 49 24 1213.5HIF1A, VEGFA, FGF2, ALB, TNFSF10, TNFRSF11B
7topotecan43 129.5HIF1A, TNFSF10, VEGFA, TOP1, MUC16
8gefitinib43 49 1210.5FGF2, TOP1, VIM, TNFSF10, VEGFA, ALB
9adriamycin438.5VIM, HIF1A, CEACAM3, TOP1, MUC1, TNFSF10
10thymidine43 249.4PSG2, CEACAM3, MUC1, CHKB, HIF1A, NPPB
11glycogen43 249.4VIM, CHKB, PSG2, S100B, PIK3C2A, MUC1
12b 723438.4S100B, CEACAM3, PSG2, MUC1, MUC16, VIM
135fluorouracil438.4VEGFA, TOP1, TNFSF10, CEACAM3, MUC1, HIF1A
14irinotecan43 49 1210.4TNFSF10, ALB, VEGFA, HIF1A, TOP1, CEACAM3
15sb 20358043 599.3FGF2, NPPB, VEGFA, TNFSF10, TNFRSF11B, HIF1A
16hematoxylin438.3S100B, VIM, MUC16, MUC1, CEACAM3, PSG2
17ascorbic acid43 249.2ALB, CHKB, HIF1A, TNFRSF11B, PIK3C2A, FGF2
18melphalan43 49 1210.2PIK3C2A, TNFSF10, MUC16, CHKB, TOP1
19actinomycin d438.2VIM, MUC1, TNFSF10, TOP1, VEGFA, HIF1A
20thyroxine43 249.1PIK3C2A, NPPB, FGF2, ALB, CEACAM3, CHKB
21genistein43 28 59 2 24 1213.0VEGFA, TNFRSF11B, HIF1A, VIM, NPPB, FGF2
22nitric oxide43 24 1210.0TNFSF10, CEACAM3, CHKB, MUC1, HIF1A, TNFRSF11B
23cyclosporin a43 28 5910.0PIK3C2A, CHKB, NPPB, HIF1A, TNFRSF11B, FGF2
24gold438.0TNFRSF11B, MUC16, PIK3C2A, CEACAM3, PSG2, MUC1
25tamoxifen43 49 28 1211.0CHKB, CEACAM3, MUC1, HIF1A, TNFRSF11B, TNFSF10
26hyaluronic acid43 248.9MUC16, FGF2, ALB, MUC1, VEGFA, VIM
27prednisolone43 28 129.8TNFRSF11B, MUC16, CHKB, ALB, NPPB, FGF2
28cysteine437.7NPPB, ALB, S100B, VIM, TNFRSF11B, HIF1A
29h2o2437.7ADA, FGF2, CHKB, HIF1A, TNFSF10, VIM
30atp43 288.6CHKB, VIM, ADA, S100B, TNFSF10, PIK3C2A
31aspartate437.6PIK3C2A, VIM, TNFRSF11B, CHKB, CEACAM3, S100B
32paclitaxel43 49 129.4VEGFA, TNFSF10, VIM, MUC16, ADA, TOP1
33estradiol43 24 129.4NPPB, VIM, MUC16, MUC1, CHKB, ALB
34alanine437.3CEACAM3, ADA, HIF1A, VIM, CHKB, ALB
35heparin43 28 24 1210.3NPPB, VEGFA, TNFRSF11B, VIM, TOP1, CHKB
36lipid437.3TNFRSF11B, PSG2, NPPB, S100B, ALB, ACADVL
37methotrexate49 43 129.1MUC1, PIK3C2A, TNFSF10, TNFRSF11B, HIF1A, VIM
38paraffin437.0VEGFA, HIF1A, FGF2, VIM, MUC16, MUC1
39progesterone43 28 59 24 1211.0CEACAM3, PIK3C2A, NPPB, S100B, TNFSF10, MUC1
40iron43 248.0VIM, TNFSF10, TNFRSF11B, ALB, PIK3C2A, NPPB
41steroid436.8CHKB, NPPB, S100B, CEACAM3, MUC16, TNFRSF11B
42dexamethasone43 49 28 129.7TNFRSF11B, HIF1A, VIM, MUC16, MUC1, ADA
43lactate436.5NPPB, S100B, PIK3C2A, HIF1A, VIM, MUC16
44testosterone43 59 24 129.5ALB, TNFSF10, TNFRSF11B, HIF1A, VIM, MUC16
45tyrosine436.2MUC16, HIF1A, MUC1, CEACAM3, S100B, NPPB
46estrogen436.1S100B, CEACAM3, CHKB, ADA, MUC1, MUC16
47doxorubicin43 49 128.1VEGFA, PIK3C2A, TNFSF10, TNFRSF11B, NPPB, PSG2
48creatinine436.1NPPB, S100B, PIK3C2A, TNFRSF11B, VIM, MUC16
49glucose436.0PIK3C2A, TNFSF10, TNFRSF11B, HIF1A, MUC16, MUC1
50vegf435.3CEACAM3, CHKB, ADA, MUC1, MUC16, VIM

GO Terms for genes affiliated with Pericardial Effusion

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Cellular components related to Pericardial Effusion according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.5FGF2, VEGFA, NPPB, S100B, ALB, PSG2
2extracellular vesicular exosomeGO:00700627.4ALB, MUC1, MUC16, VIM, TNFSF10, PIK3C2A
3extracellular spaceGO:00056156.9ALB, FGF2, S100B, ADA, MUC16, TNFRSF11B

Biological processes related to Pericardial Effusion according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of thymocyte apoptotic processGO:007024410.1ADA, HIF1A
2positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:00614199.9VEGFA, HIF1A
3dopaminergic neuron differentiationGO:00715429.8HIF1A, VEGFA
4cell migration involved in sprouting angiogenesisGO:00020429.8FGF2, VEGFA
5positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:00309499.7VEGFA, HIF1A
6positive regulation of blood vessel endothelial cell migrationGO:00435369.6VEGFA, FGF2
7cellular response to hypoxiaGO:00714569.6S100B, HIF1A, VEGFA
8positive regulation of endothelial cell proliferationGO:00019389.6FGF2, HIF1A, VEGFA
9positive regulation of angiogenesisGO:00457669.5FGF2, VEGFA, HIF1A
10response to hypoxiaGO:00016669.5VEGFA, HIF1A, ADA
11positive regulation of neuroblast proliferationGO:00020529.4VEGFA, HIF1A

Molecular functions related to Pericardial Effusion according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:00420569.7FGF2, VEGFA
2cytokine activityGO:00051258.9FGF2, TNFRSF11B, TNFSF10, VEGFA
3protein bindingGO:00055155.9VEGFA, TNFSF10, HIF1A, VIM, MUC16, MUC1

Products for genes affiliated with Pericardial Effusion

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Sources for Pericardial Effusion

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet