MCID: PRC010
MIFTS: 37

Pericardial Mesothelioma malady

Categories: Cancer diseases, Cardiovascular diseases

Aliases & Classifications for Pericardial Mesothelioma

Aliases & Descriptions for Pericardial Mesothelioma:

Name: Pericardial Mesothelioma 12 14 69
Malignant Mesothelioma of Pericardium 12
Malignant Pericardial Mesothelioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6201
ICD10 33 C45.2
SNOMED-CT 64 109383000 187885008

Summaries for Pericardial Mesothelioma

MalaCards based summary : Pericardial Mesothelioma, also known as malignant mesothelioma of pericardium, is related to unknown leukodystrophy and subglottis verrucous carcinoma. An important gene associated with Pericardial Mesothelioma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. The drugs Cisplatin and Pemetrexed have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and brain, and related phenotypes are Negative genetic interaction between PTEN-/- and PTEN+/+ and cellular

Related Diseases for Pericardial Mesothelioma

Diseases related to Pericardial Mesothelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
id Related Disease Score Top Affiliating Genes
1 unknown leukodystrophy 10.4 KRT19 VIM
2 subglottis verrucous carcinoma 10.3 KRT10 MUC1 VIM
3 thymus mucoepidermoid carcinoma 10.3 KRT10 MUC1 MUC16
4 omodysplasia 2 10.3 MUC1 S100A1 VIM
5 popliteal pterygium syndrome, bartsocas-papas type 10.3 MUC1 S100A1 VIM
6 avian influenza 10.3 MUC1 THBD VIM
7 myelinoclastic diffuse sclerosis 10.3 ENO2 MUC1
8 viral infectious disease 10.3 KRT19 SMUG1
9 occlusion precerebral artery 10.3 MUC1 S100A1 VIM
10 desmoid tumor 10.2 MPO MUC1 VIM
11 skeletal-extraskeletal angiomatosis 10.2 ENO2 MUC1
12 cyanide-induced parkinsonism 10.2 CALB2 MUC16
13 eccrine papillary adenoma 10.2 KRT19 KRT7
14 cervix endometrial stromal tumor 10.2 FOXK1 HBA1
15 dementia 10.2 MUC16 SMUG1
16 proteus-like syndrome 10.2 KRT19 KRT7
17 childhood brain germinoma 10.2 ENO2 MUC1 VIM
18 handigodu disease 10.2 CALB2 VIM
19 laryngeal small cell carcinoma 10.2 ENO2 SMUG1
20 benign schwannoma 10.2 ENO2 VIM
21 malignant mixed mullerian tumor 10.2 ENO2 S100A1
22 thymic dysplasia 10.2 CALB2 MUC1
23 osteosarcoma arising in bone paget's disease 10.2 KRT19 KRT7
24 breast squamous cell carcinoma 10.2 ENO2 MUC1 VIM
25 central nervous system hemangioma 10.2 ENO2 MUC1 VIM
26 epimetaphyseal dysplasia cataract 10.2 ENO2 MUC1 VIM
27 intracranial sinus thrombosis 10.2 MPO VIM
28 diarrhea, chronic, with villous atrophy 10.2 HBA1 MUC1 VIM
29 myoma 10.2 MUC1 VIM
30 breast medullary carcinoma 10.2 CALB2 PTGER4
31 hereditary conventional renal cell carcinoma 10.2 KRT7 PTGER4
32 lymphangiosarcoma 10.2 CALB2 MUC1 VIM
33 gestational trophoblastic neoplasm 10.2 CALB2 MUC1 VIM
34 appendix mucinous cystadenocarcinoma 10.2 KRT7 MUC1 VIM
35 prolactin producing pituitary tumor 10.2 ENO2 MUC1
36 nutritional deficiency disease 10.2 SMUG1 VIM
37 papillary adenofibroma 10.2 KRT19 KRT7 MUC1
38 lung combined type small cell carcinoma 10.2 KRT19 KRT7 MUC1
39 alcohol-induced mental disorder 10.2 HBA1 THBD VIM
40 distal arthrogryposis 10.2 KRT10 KRT19 KRT7
41 anthrax disease 10.2 HBA1 SMUG1
42 intestinal benign neoplasm 10.2 KRT7 MUC1 VIM
43 kidney benign neoplasm 10.2 KRT7 MUC1 VIM
44 ebola hemorrhagic fever 10.2 KRT10 KRT7 PTGER4
45 autosomal recessive stickler syndrome 10.2 ENO2 MUC1 S100A1 VIM
46 epidermolysis bullosa simplex-mp 10.2 KRT10 KRT19 KRT7
47 pericarditis 10.2
48 differentiating neuroblastoma 10.2 ENO2 MUC1 S100A1 VIM
49 breast adenocarcinoma 10.2 KRT19 KRT7
50 impaired renal function disease 10.2 ERF HBA1 SMUG1

Graphical network of the top 20 diseases related to Pericardial Mesothelioma:



Diseases related to Pericardial Mesothelioma

Symptoms & Phenotypes for Pericardial Mesothelioma

GenomeRNAi Phenotypes related to Pericardial Mesothelioma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between PTEN-/- and PTEN+/+ GR00255-A-3 9.1 CD99 ENO2 KRT10 MPO SMUG1 THBD

MGI Mouse Phenotypes related to Pericardial Mesothelioma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.36 PTGER4 S100A1 SMUG1 THBD VIM ENO2

Drugs & Therapeutics for Pericardial Mesothelioma

Drugs for Pericardial Mesothelioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
2
Pemetrexed Approved, Investigational Phase 2 150399-23-8, 137281-23-3 446556 60843
3
leucovorin Approved, Nutraceutical Phase 2 58-05-9 54575, 6560146 143
4
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
5 Folic Acid Antagonists Phase 2
6 Nucleic Acid Synthesis Inhibitors Phase 2
7 Vitamin B Complex Phase 2
8 Folate Nutraceutical Phase 2
9 Vitamin B9 Nutraceutical Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Triplet Combination First Line Treatment in Non Small Cell Lung Cancer (NSCLC) Completed NCT00942825 Phase 2

Search NIH Clinical Center for Pericardial Mesothelioma

Genetic Tests for Pericardial Mesothelioma

Anatomical Context for Pericardial Mesothelioma

MalaCards organs/tissues related to Pericardial Mesothelioma:

39
Heart, Liver, Brain

Publications for Pericardial Mesothelioma

Articles related to Pericardial Mesothelioma:

(show top 50) (show all 108)
id Title Authors Year
1
F-18 FDG PET/CT images of a rare primer cardiac tumour: Primary Pericardial Mesothelioma. ( 27515105 )
2016
2
Pericardial mesothelioma. ( 27318362 )
2016
3
Pericardial Effusion due to Primary Malignant Pericardial Mesothelioma: A Common Finding but an Uncommon Cause. ( 28003826 )
2016
4
Sarcomatoid Type Primary Pericardial Mesothelioma with a Long-term Survival after the Onset of Cardiac Tamponade. ( 27803412 )
2016
5
Positive response of a primary malignant pericardial mesothelioma to pemetrexed plus cisplatin followed by pemetrexed maintenance chemotherapy: A case report. ( 27347127 )
2016
6
Primary malignant pericardial mesothelioma with increased serum mesothelin diagnosed by surgical pericardial resection: A case report. ( 27900083 )
2016
7
Pericardial Mesothelioma in a Yellow-naped Amazon Parrot ( Amazona auropalliata ). ( 25867668 )
2015
8
Endobronchial ultrasound-guided transbronchial needle aspiration in a patient with pericardial mesothelioma. ( 25742892 )
2015
9
Successful palliation for an aged patient with primary pericardial mesothelioma. ( 26376726 )
2015
10
A rare case of primary malignant pericardial mesothelioma. ( 25250196 )
2014
11
Primary malignant pericardial mesothelioma-a rare cause of superior vena cava thrombosis and constrictive pericarditis. ( 25590007 )
2014
12
A rare cause of heart failure with preserved ejection fraction: primary pericardial mesothelioma masquerading as pericardial constriction. ( 24654246 )
2014
13
Cardiac MRI findings in a dog with a diffuse pericardial mesothelioma and pericardial effusion. ( 24051256 )
2013
14
Primary pericardial mesothelioma: a rare entity. ( 23840993 )
2013
15
Three-year survival after surgery for primary malignant pericardial mesothelioma: report of a case. ( 23408086 )
2013
16
Primary pericardial mesothelioma in a 19-year-old presenting as pericarditis. ( 23353042 )
2013
17
Mixed form of pericardial mesothelioma with osseous differentiation in a dog. ( 23578582 )
2013
18
Primary pericardial mesothelioma: A rare cause of constrictive pericarditis. ( 24887935 )
2013
19
Primary sarcomatoid malignant pericardial mesothelioma. ( 23291695 )
2013
20
Unexpected malignant pericardial mesothelioma presenting as pericardial constriction. ( 23094904 )
2012
21
Fluorine-18 fluoro-2-deoxyglucose positron emission tomography/computed tomography in a case of suspected primary pericardial mesothelioma. ( 23919083 )
2012
22
False aneurysm of ascending aorta due to pericardial mesothelioma. ( 22593561 )
2012
23
Primary malignant pericardial mesothelioma presenting as acute pericarditis. ( 22509441 )
2012
24
Primary pericardial mesothelioma unique case and literature review. ( 22740748 )
2012
25
A case of primary pericardial mesothelioma detected by 18F-FDG PET/CT. ( 22475912 )
2012
26
A case report of an extremely rare and aggressive tumor: primary malignant pericardial mesothelioma. ( 22826778 )
2012
27
A case of malignant pericardial mesothelioma with constrictive pericarditis physiology misdiagnosed as pericardial metastatic cancer. ( 21779289 )
2011
28
Pericardial mesothelioma and asbestos exposure. ( 21156353 )
2011
29
Primary malignant pericardial mesothelioma presenting as effusive-constrictive pericarditis. ( 21828406 )
2011
30
Malignant pericardial mesothelioma. ( 20643560 )
2011
31
Primary malignant pericardial mesothelioma mimicking pericardial metastasis from adenocarcinoma. ( 21102264 )
2010
32
Primary pericardial mesothelioma in an asbestos-exposed patient with previous heart surgery. ( 20530447 )
2010
33
Surprising finding of a primary pericardial mesothelioma. ( 20339921 )
2010
34
Malignant pericardial mesothelioma following thoracal radiotherapy; dissemination from pericardium to pleura. ( 21038142 )
2010
35
Primary Pericardial Mesothelioma: Report of a Patient and Literature Review. ( 20740175 )
2009
36
Malignant pericardial mesothelioma with response to chemotherapy. ( 19861909 )
2009
37
Fatal hemopericardial tamponade due to primary pericardial mesothelioma: a case report. ( 20003222 )
2009
38
Primary malignant pericardial mesothelioma - a rare cause of pericardial effusion and consecutive constrictive pericarditis: a case report. ( 19918293 )
2009
39
Primary pericardial mesothelioma. ( 17936406 )
2008
40
Pericardial mesothelioma in a Bengal tiger (Panthera tigris). ( 18432108 )
2008
41
F-18 fluorodeoxyglucose PET/CT scanning in the diagnostic work-up of a primary pericardial mesothelioma: a case report. ( 18347518 )
2008
42
Primary malignant pericardial mesothelioma presenting as pericardial constriction. ( 19131929 )
2008
43
Primary pericardial mesothelioma: a rare cardiac malignancy. ( 17640193 )
2007
44
Report of a case of pericardial mesothelioma with liver metastases responding well to pemetrexed and platinum-based chemotherapy. ( 17762349 )
2007
45
Intracavitary mass as the initial manifestation of primary pericardial mesothelioma: a case report. ( 17495278 )
2007
46
Triplet chemotherapy for malignant pericardial mesothelioma: a case report. ( 16533802 )
2006
47
Pericardial mesothelioma in a neonatal calf. ( 16757900 )
2006
48
A case of primary malignant pericardial mesothelioma. ( 15729420 )
2005
49
An autopsy case of primary pericardial mesothelioma in arc cutter exposed to asbestos through talc pencils. ( 15895852 )
2005
50
Malignant pericardial mesothelioma. Report of two cases, review of the literature and differential diagnosis. ( 16206657 )
2005

Variations for Pericardial Mesothelioma

Expression for Pericardial Mesothelioma

Search GEO for disease gene expression data for Pericardial Mesothelioma.

Pathways for Pericardial Mesothelioma

Pathways related to Pericardial Mesothelioma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.5 KRT10 KRT19 KRT7 MUC1 VIM
2
Show member pathways
11.37 KRT19 KRT7 VIM
3 9.86 HBA1 MB

GO Terms for Pericardial Mesothelioma

Cellular components related to Pericardial Mesothelioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 ENO2 HBA1 KRT10 MPO MSLN MUC1
2 intermediate filament GO:0005882 9.46 KRT10 KRT19 KRT7 VIM
3 extracellular exosome GO:0070062 9.36 ENO2 GFPT1 HBA1 KRT10 KRT19 KRT7

Biological processes related to Pericardial Mesothelioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.13 KRT10 KRT19 KRT7
2 oxygen transport GO:0015671 8.62 HBA1 MB

Molecular functions related to Pericardial Mesothelioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxygen transporter activity GO:0005344 8.62 HBA1 MB

Sources for Pericardial Mesothelioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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