MCID: PRC010
MIFTS: 36

Pericardial Mesothelioma

Categories: Cancer diseases, Cardiovascular diseases

Aliases & Classifications for Pericardial Mesothelioma

MalaCards integrated aliases for Pericardial Mesothelioma:

Name: Pericardial Mesothelioma 12 14 69
Malignant Mesothelioma of Pericardium 12
Malignant Pericardial Mesothelioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6201
ICD10 33 C45.2
SNOMED-CT 64 109383000 187885008

Summaries for Pericardial Mesothelioma

MalaCards based summary : Pericardial Mesothelioma, also known as malignant mesothelioma of pericardium, is related to senior-boichis syndrome and myeloid/lymphoid neoplasm associated with pdgfra rearrangement. An important gene associated with Pericardial Mesothelioma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. The drugs Cisplatin and Pemetrexed have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and brain, and related phenotypes are Negative genetic interaction between PTEN-/- and PTEN+/+ and cellular

Related Diseases for Pericardial Mesothelioma

Diseases related to Pericardial Mesothelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
id Related Disease Score Top Affiliating Genes
1 senior-boichis syndrome 10.9 KRT19 VIM
2 myeloid/lymphoid neoplasm associated with pdgfra rearrangement 10.9 MUC1 VIM
3 spleen angiosarcoma 10.9 MUC1 VIM
4 laryngeal neuroendocrine tumor 10.9 MUC1 VIM
5 mannose-binding lectin protein deficiency 10.8 MUC1 VIM
6 exotropia 10.8 MUC1 PTGER4
7 monieziasis 10.8 KRT19 SMUG1
8 short-rib thoracic dysplasia 12 10.8 MUC1 S100A1 VIM
9 uremic neuropathy 10.8 KRT10 MUC1 MUC16
10 noninvasive malignant thymoma 10.8 MUC1 VIM
11 pigmented basal cell carcinoma 10.8 KRT10 PTGER4
12 reticular pattern testicular yolk sac tumor 10.8 MUC1 VIM
13 inner ear cancer 10.8 SMUG1 VIM
14 polyosteolysis/hyperostosis syndrome 10.8 MUC1 S100A1 VIM
15 pyoderma 10.8 MUC1 VIM
16 mucinous ovarian cystadenoma 10.8 MB MUC1
17 dementia 10.7 MUC16 SMUG1
18 pancreatic intraductal papillary-colloid carcinoma 10.7 MUC1 VIM
19 meningitis and encephalitis 10.7 ENO2 MUC1
20 situs inversus totalis with cystic dysplasia of kidneys and pancreas 10.7 ENO2 MUC1
21 pseudomyxoma peritonei 10.7 MPO VIM
22 persian gulf syndrome 10.7 MUC1 THBD VIM
23 benallegue lacete syndrome 10.7 ENO2 VIM
24 intellectual disability-polydactyly-uncombable hair syndrome 10.7 ENO2 VIM
25 bladder colloid adenocarcinoma 10.7 MUC1 VIM
26 bronchus adenoma 10.7 ENO2 MUC1
27 7p22.1 microduplication syndrome 10.7 CALB2 MUC16
28 malignant hyperthermia susceptibility type 3 10.7 ENO2 S100A1
29 bladder urachal squamous cell carcinoma 10.7 MUC1 S100A1 VIM
30 conventional malignant hemangiopericytoma 10.7 MB MUC1 VIM
31 cellular ependymoma 10.7 MUC1 VIM
32 pleomorphic adenoma 10.6 FOXK1 HBA1
33 hairy palms and soles 10.6 CALB2 VIM
34 iris spindle cell melanoma 10.6 CALB2 MUC1
35 pineal region yolk sac tumor 10.6 ENO2 VIM
36 enteric pattern testicular yolk sac tumor 10.6 ENO2 MUC1
37 eccrine acrospiroma 10.6 KRT19 KRT7
38 breast cystic hypersecretory carcinoma 10.6 KRT19 KRT7
39 lice infestation 10.6 MUC1 VIM
40 dense deposit disease 10.6 MPO MUC1 VIM
41 prostaglandin-endoperoxide synthase deficiency 10.6 KRT19 KRT7
42 myoma 10.6 ENO2 MUC1 VIM
43 morbid obesity 10.6 ENO2 MUC1
44 cervix erosion 10.6 KRT19 KRT7
45 skin papilloma 10.6 ENO2 VIM
46 cervical endometrial stromal sarcoma 10.6 FOXK1 HBA1
47 vulvar keratoacanthoma-like carcinoma 10.6 ENO2 MUC1 VIM
48 trachea adenoid cystic carcinoma 10.6 KRT19 KRT7
49 ampulla of vater squamous cell carcinoma 10.6 HBA1 VIM
50 myxoid leiomyosarcoma 10.6 ENO2 VIM

Graphical network of the top 20 diseases related to Pericardial Mesothelioma:



Diseases related to Pericardial Mesothelioma

Symptoms & Phenotypes for Pericardial Mesothelioma

GenomeRNAi Phenotypes related to Pericardial Mesothelioma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between PTEN-/- and PTEN+/+ GR00255-A-3 9.1 CD99 ENO2 KRT10 MPO SMUG1 THBD

MGI Mouse Phenotypes related to Pericardial Mesothelioma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.36 FOXK1 KRT19 KRT7 MB PTGER4 S100A1

Drugs & Therapeutics for Pericardial Mesothelioma

Drugs for Pericardial Mesothelioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
2
Pemetrexed Approved, Investigational Phase 2 150399-23-8, 137281-23-3 446556 60843
3
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
4
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
5 Folic Acid Antagonists Phase 2
6 Nucleic Acid Synthesis Inhibitors Phase 2
7 Vitamin B Complex Phase 2
8 Folate Nutraceutical Phase 2
9 Vitamin B9 Nutraceutical Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Triplet Combination First Line Treatment in Non Small Cell Lung Cancer (NSCLC) Completed NCT00942825 Phase 2 CBP501 + Cisplatin + Pemetrexed;Cisplatin + Pemetrexed

Search NIH Clinical Center for Pericardial Mesothelioma

Genetic Tests for Pericardial Mesothelioma

Anatomical Context for Pericardial Mesothelioma

MalaCards organs/tissues related to Pericardial Mesothelioma:

39
Lung, Heart, Brain, Liver

Publications for Pericardial Mesothelioma

Articles related to Pericardial Mesothelioma:

(show top 50) (show all 112)
id Title Authors Year
1
Pericardial mesothelioma presenting as a suspected ST-elevation myocardial infarction. ( 28343785 )
2017
2
Primary pericardial mesothelioma and asbestos exposure: a rare fatal disease. ( 28500034 )
2017
3
Malignant pericardial mesothelioma : AA systematic review of current practice. ( 28130567 )
2017
4
A second case of pericardial mesothelioma mimicking systemic lupus erythematosus in the literature in over 30 years: a case report. ( 28351431 )
2017
5
Pericardial mesothelioma. ( 27318362 )
2016
6
F-18 FDG PET/CT images of a rare primer cardiac tumour: Primary Pericardial Mesothelioma. ( 27515105 )
2016
7
Primary malignant pericardial mesothelioma with increased serum mesothelin diagnosed by surgical pericardial resection: A case report. ( 27900083 )
2016
8
Positive response of a primary malignant pericardial mesothelioma to pemetrexed plus cisplatin followed by pemetrexed maintenance chemotherapy: A case report. ( 27347127 )
2016
9
Sarcomatoid Type Primary Pericardial Mesothelioma with a Long-term Survival after the Onset of Cardiac Tamponade. ( 27803412 )
2016
10
Pericardial Effusion due to Primary Malignant Pericardial Mesothelioma: A Common Finding but an Uncommon Cause. ( 28003826 )
2016
11
Pericardial Mesothelioma in a Yellow-naped Amazon Parrot ( Amazona auropalliata ). ( 25867668 )
2015
12
Successful palliation for an aged patient with primary pericardial mesothelioma. ( 26376726 )
2015
13
Endobronchial ultrasound-guided transbronchial needle aspiration in a patient with pericardial mesothelioma. ( 25742892 )
2015
14
Primary malignant pericardial mesothelioma-a rare cause of superior vena cava thrombosis and constrictive pericarditis. ( 25590007 )
2014
15
A rare cause of heart failure with preserved ejection fraction: primary pericardial mesothelioma masquerading as pericardial constriction. ( 24654246 )
2014
16
A rare case of primary malignant pericardial mesothelioma. ( 25250196 )
2014
17
Primary pericardial mesothelioma: A rare cause of constrictive pericarditis. ( 24887935 )
2013
18
Primary sarcomatoid malignant pericardial mesothelioma. ( 23291695 )
2013
19
Primary pericardial mesothelioma: a rare entity. ( 23840993 )
2013
20
Primary pericardial mesothelioma in a 19-year-old presenting as pericarditis. ( 23353042 )
2013
21
Cardiac MRI findings in a dog with a diffuse pericardial mesothelioma and pericardial effusion. ( 24051256 )
2013
22
Three-year survival after surgery for primary malignant pericardial mesothelioma: report of a case. ( 23408086 )
2013
23
Mixed form of pericardial mesothelioma with osseous differentiation in a dog. ( 23578582 )
2013
24
A case of primary pericardial mesothelioma detected by 18F-FDG PET/CT. ( 22475912 )
2012
25
Primary pericardial mesothelioma unique case and literature review. ( 22740748 )
2012
26
A case report of an extremely rare and aggressive tumor: primary malignant pericardial mesothelioma. ( 22826778 )
2012
27
Fluorine-18 fluoro-2-deoxyglucose positron emission tomography/computed tomography in a case of suspected primary pericardial mesothelioma. ( 23919083 )
2012
28
False aneurysm of ascending aorta due to pericardial mesothelioma. ( 22593561 )
2012
29
Primary malignant pericardial mesothelioma presenting as acute pericarditis. ( 22509441 )
2012
30
Unexpected malignant pericardial mesothelioma presenting as pericardial constriction. ( 23094904 )
2012
31
Pericardial mesothelioma and asbestos exposure. ( 21156353 )
2011
32
A case of malignant pericardial mesothelioma with constrictive pericarditis physiology misdiagnosed as pericardial metastatic cancer. ( 21779289 )
2011
33
Malignant pericardial mesothelioma. ( 20643560 )
2011
34
Primary malignant pericardial mesothelioma presenting as effusive-constrictive pericarditis. ( 21828406 )
2011
35
Malignant pericardial mesothelioma following thoracal radiotherapy; dissemination from pericardium to pleura. ( 21038142 )
2010
36
Primary malignant pericardial mesothelioma mimicking pericardial metastasis from adenocarcinoma. ( 21102264 )
2010
37
Surprising finding of a primary pericardial mesothelioma. ( 20339921 )
2010
38
Primary pericardial mesothelioma in an asbestos-exposed patient with previous heart surgery. ( 20530447 )
2010
39
Fatal hemopericardial tamponade due to primary pericardial mesothelioma: a case report. ( 20003222 )
2009
40
Primary Pericardial Mesothelioma: Report of a Patient and Literature Review. ( 20740175 )
2009
41
Malignant pericardial mesothelioma with response to chemotherapy. ( 19861909 )
2009
42
Primary malignant pericardial mesothelioma - a rare cause of pericardial effusion and consecutive constrictive pericarditis: a case report. ( 19918293 )
2009
43
Primary malignant pericardial mesothelioma presenting as pericardial constriction. ( 19131929 )
2008
44
Pericardial mesothelioma in a Bengal tiger (Panthera tigris). ( 18432108 )
2008
45
Primary pericardial mesothelioma. ( 17936406 )
2008
46
F-18 fluorodeoxyglucose PET/CT scanning in the diagnostic work-up of a primary pericardial mesothelioma: a case report. ( 18347518 )
2008
47
Intracavitary mass as the initial manifestation of primary pericardial mesothelioma: a case report. ( 17495278 )
2007
48
Primary pericardial mesothelioma: a rare cardiac malignancy. ( 17640193 )
2007
49
Report of a case of pericardial mesothelioma with liver metastases responding well to pemetrexed and platinum-based chemotherapy. ( 17762349 )
2007
50
Triplet chemotherapy for malignant pericardial mesothelioma: a case report. ( 16533802 )
2006

Variations for Pericardial Mesothelioma

Expression for Pericardial Mesothelioma

Search GEO for disease gene expression data for Pericardial Mesothelioma.

Pathways for Pericardial Mesothelioma

Pathways related to Pericardial Mesothelioma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.5 KRT10 KRT19 KRT7 MUC1 VIM
2
Show member pathways
11.37 KRT19 KRT7 VIM
3 9.86 HBA1 MB

GO Terms for Pericardial Mesothelioma

Cellular components related to Pericardial Mesothelioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 ENO2 HBA1 KRT10 MPO MSLN MUC1
2 extracellular exosome GO:0070062 9.36 ENO2 GFPT1 HBA1 KRT10 KRT19 KRT7
3 intermediate filament GO:0005882 9.26 KRT10 KRT19 KRT7 VIM

Biological processes related to Pericardial Mesothelioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxygen transport GO:0015671 8.62 HBA1 MB

Molecular functions related to Pericardial Mesothelioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxygen transporter activity GO:0005344 8.62 HBA1 MB

Sources for Pericardial Mesothelioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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