MCID: PRC013
MIFTS: 48

Pericarditis malady

Cardiovascular category

Summaries for Pericarditis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Pericarditis is an inflammation of the pericardium (the fibrous sac surrounding the heart). A... more...

MalaCards: Pericarditis is related to constrictive pericarditis and arthritis, and has symptoms including chest pain An important gene associated with Pericarditis is PRG4 (proteoglycan 4), and among its related pathways are Regulation by c-FLIP and NF-kappaB Signaling. The compounds isoproterenol and indomethacin have been mentioned in the context of this disorder. Related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A heart disease that is characterized by an inflammation of the pericardium and has symptom chest pain.

Aliases & Classifications for Pericarditis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 36MESH via Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Characteristics (Orphanet epidemiological data):

49
pericarditis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

pericarditis 8 10 45 49 61


External Ids:

Disease Ontology8 DOID:1787
MeSH35 D010493
NCIt40 C34915
SNOMED-CT via Orphanet58 23627006, 3238004
SNOMED-CT57 3238004
UMLS via Orphanet62 C0031046, C0265143
MESH via Orphanet36 D010493
ICD10 via Orphanet26 I30
ICD1025 I32, I32.8

Related Diseases for Pericarditis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pericarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 330)
idRelated DiseaseScoreTop Affiliating Genes
1constrictive pericarditis31.7ADA, NPPB
2arthritis30.6TNFRSF1A, TNF, MEFV, VTN, ALB
3tuberculosis30.5TNFRSF1A, TNF, ALB, ADA
4arthropathy30.4PRG4, TNF
5protein-losing enteropathy30.4ALB
6acute myocardial infarction30.3TNNI3, NPPB, MEFV
7systemic lupus erythematosus30.3TNFRSF1A, TNF, VTN, ADA
8amyloidosis30.2TNFRSF1A, NPPB, MEFV, ALB
9vasculitis30.1TNF, MEFV, ALB
10hepatitis c30.0ALB
11familial mediterranean fever29.9MEFV, TNF, TNFRSF1A
12asthma29.9TNF, IGHE, HRH4, VTN
13kawasaki disease29.7NPPB
14cystic fibrosis29.7ALB
15hypertrophic cardiomyopathy29.7TNNI3
16uveitis29.7TNF, TNFRSF1A
17crohn's disease29.7ALB, TNF
18adenocarcinoma29.7PSG2, VTN, ADA
19behcet's disease29.7TNF, MEFV, ADA
20blau syndrome29.6TNF, MEFV
21sepsis29.6TNFRSF1A, TNF, NPPB, VTN, ALB
22cardiac tamponade10.6
23camptodactyly arthropathy coxa vara pericarditis syndrome10.5
24idiopathic recurrent pericarditis10.5
25hemopericardium10.4
26chylous ascites10.3
27pericardial mesothelioma10.2
28pericardial tuberculosis10.2
29n syndrome10.2
30acute myocarditis10.2
31aortic aneurysm10.2
32histoplasmosis pericarditis10.2
33mycobacterium kansasii10.1
34meningococcal meningitis10.1
35chronic rheumatic pericarditis10.1
36mulibrey nanism10.1
37inferior myocardial infarction10.1
38hepatitis a10.1
39mixed connective tissue disease10.0
40aseptic meningitis10.0
41dressler's syndrome10.0
42melioidosis10.0
43septic arthritis10.0
44acute leukemia10.0
45ventricular septal defect10.0
46degos disease10.0
47meningococcal infection10.0
48syncope10.0
49intestinal lymphangiectasia10.0
50sarcoma10.0ADA

Graphical network of the top 20 diseases related to Pericarditis:



Diseases related to pericarditis

Clinical Features for Pericarditis

Sources:
8Disease Ontology
See all sources


Symptoms:

8
  • chest pain

Drugs & Therapeutics for Pericarditis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pericarditis

Drug clinical trials:

Search ClinicalTrials for Pericarditis

Search NIH Clinical Center for Pericarditis

Search CenterWatch for Pericarditis

Genetic Tests for Pericarditis

Anatomical Context for Pericarditis

Animal Models for Pericarditis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Pericarditis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053879.2TNF, IRAK4, MEFV, IGHE, BATF2, REN
2MP:00053979.1VTN, SLC22A12, REN, IGHE, IRAK4, TNF
3MP:00053768.8SAR1B, ADA, ALB, VTN, SLC22A12, HRH4
4MP:00107688.7ADA, TNF, TNNI3, MEFV, PRG4, BATF2

Publications for Pericarditis

Sources:
51PubMed
See all sources

Articles related to Pericarditis:

(show top 50)    (show all 1008)
idTitleAuthorsYear
1
Cardiac tamponade with community-acquired methicillin-resistant Staphylococcus aureus pericarditis. (23903515)
2013
2
Pericarditis, myocarditis, and other cardiomyopathies. (23402470)
2013
3
Idiopathic recurrent pericarditis treated successfully with tumour necrosis factor alpha blocking agents (anti-TNF-I+). (23711245)
2013
4
Prevention of recurrent pericarditis with colchicine in 2012. (23404655)
2013
5
Severe constrictive pericarditis after parvovirus B19 and human herpes virus 6 infection in a 9-year-old girl. (23864223)
2013
6
Pyopericardium followed by constrictive pericarditis due to Corynebacterium diphtheriae. (22402499)
2012
7
The prevalence and outcome of effusive constrictive pericarditis: a systematic review of the literature. (22240903)
2012
8
Infected esophageal duplication cyst masquerading as pericarditis. (22449694)
2012
9
Pericarditis as an initial symptom in Takayasu arteritis. (21592931)
2011
10
Towards evidence-based emergency medicine: best BETs from the Manchester Royal Infirmary. BET 3: colchicine as an adjunct to nonsteroidal anti-inflammatory drugs for the treatment of acute pericarditis. (21367801)
2011
11
Tuberculous pericarditis associated with hoarseness of voice due to left recurrent laryngeal nerve paralysis. (22675007)
2011
12
Pericarditis constrictiva in a 10-year-old boy after influenza A virus infection. (21267717)
2011
13
Chronic constrictive pericarditis in association with end-stage renal disease. (21603101)
2011
14
Influenza virus B-associated hemophagocytic syndrome and recurrent pericarditis in a patient with systemic lupus erythematosus. (19898920)
2010
15
Clozapine rechallenge following clozapine-induced pericarditis. (20667298)
2010
16
Severe bivalvular pneumococcal endocarditis and suppurative pericarditis in an immunocompetent patient. (20154438)
2010
17
Medical therapy of pericardial diseases: part I: idiopathic and infectious pericarditis. (20736783)
2010
18
Pericarditis. (20124280)
2010
19
Unresolving pericarditis: suspect filariasis in the tropics. (20061773)
2010
20
Bronchogenic cyst masquerading as pericarditis. (20713905)
2010
21
Idiopathic recurrent pericarditis: searching for Ariadne's thread. (19767277)
2009
22
Calcified constrictive pericarditis, aortic stenosis, and coronary artery disease: diagnosis and treatment solutions for a 78-year-old patient. (18828461)
2008
23
Severely calcified constrictive pericarditis simulating a mediastinal tumor and obstructing the right ventricular inflow tract. (18292726)
2007
24
Comorbidity of constrictive pericarditis and hemophilia A. (16651841)
2006
25
Purulent pericarditis and pleural empyema due to Staphylococcus aureus septicemia. (16337509)
2006
26
Metal fume fever presenting as aseptic meningitis with pericarditis, pleuritis and pneumonitis. (16314334)
2005
27
Left ventricular dysfunction after pericardiectomy for constrictive pericarditis. (15063292)
2004
28
Eosinophilic pericarditis: a rare complication of idiopathic hypereosinophilic syndrome in a child. (14743307)
2004
29
Chylous ascites and pleural effusion secondary to constrictive pericarditis presenting with signs of lymphatic obstruction. (15240974)
2004
30
Constrictive pericarditis caused by infiltration of non-Hodgkin's lymphoma. (12117839)
2002
31
Perioperative myocardial infarction in a patient with tuberculous constrictive pericarditis in the absence of coronary artery disease. (11292907)
2001
32
Annulus paradoxus: transmitral flow velocity to mitral annular velocity ratio is inversely proportional to pulmonary capillary wedge pressure in patients with constrictive pericarditis. (11524387)
2001
33
Clinical variability and genetic homogeneity of the camptodactyly-arthropathy-coxa vara-pericarditis syndrome. (11102929)
2000
34
Mitral regurgitation after pericardiectomy for constrictive pericarditis. (10077890)
1999
35
Constrictive pericarditis in the modern era: evolving clinical spectrum and impact on outcome after pericardiectomy. (10500037)
1999
36
Geriatrics photo quiz. Chronic constrictive pericarditis. (10086023)
1999
37
Other diseases with diastolic dysfunction: how to deal with? Constrictive pericarditis. (10582464)
1999
38
Constrictive pericarditis. (10475796)
1999
39
Constrictive pericarditis and tuberculosis. (9413496)
1997
40
Transient tuberculous constrictive pericarditis. (8631575)
1996
41
Clinical relevance of Doppler pulmonary venous flow characteristics in constrictive pericarditis. (7671896)
1995
42
Hepatic coma as a presenting feature of constrictive pericarditis. (8438853)
1993
43
Transesophageal Doppler echocardiographic demonstration of pulmonary venous flow velocity in restrictive cardiomyopathy and constrictive pericarditis. (2712000)
1989
44
Pericarditis with pericardial effusion complicating chickenpox. (3658852)
1986
45
Septic rheumatoid pericarditis complicating Felty's syndrome. (7317124)
1981
46
Fungal endocarditis complicated by mycotic aneurysm of sinus of Valsalva, interventricular septal abscess, and infectious pericarditis: unique M-mode and two-dimensional echocardiographic findings. (6894413)
1981
47
Cardiac amyloidosis, contrictive pericarditis and restrictive cardiomyopathy. (983951)
1976
48
Cardiac complications of chronic, severe, refractory anemia with hemochromatosis. I. Acute pericarditis of unkown etiology. (13767975)
1961
49
Primary systemic amyloidosis simulating constrictive pericarditis; with steatorrhea and hyperesthesia. (18879125)
1948
50
Septicemia with Acute Fibrino-Purulent Pericarditis and Hypopyon Iritis caused by the Meningococcus. (19971859)
1908

Genetic Variations for Pericarditis

Expression for genes affiliated with Pericarditis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pericarditis

Search GEO for disease gene expression data for Pericarditis.

Pathways for genes affiliated with Pericarditis

Sources:
54Reactome, 4Cell Signaling Technology, 30KEGG
See all sources

Pathways related to Pericarditis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2TNF, TNFRSF1A
210.1IRAK4, TNF, TNFRSF1A
310.1IRAK4, TNF, TNFRSF1A

Compounds for genes affiliated with Pericarditis

Sources:
45Novoseek, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 24HMDB, 50PharmGKB
See all sources

Compounds related to Pericarditis according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1isoproterenol45 1111.7ADA
2indomethacin45 60 29 1113.7NPPB, REN
3ornipressin4510.6ALB, REN
4alacepril4510.6NPPB, REN
5prednisolone45 29 1112.6IGHE, NPPB
6norepinephrine45 11 2412.5IGHE, TNFRSF1A
7fosinopril45 1111.5ALB, REN, NPPB
8lisinopril45 11 2412.5ALB, REN, NPPB
9darusentan45 2911.5REN, NPPB
10ramipril45 1111.5ALB, REN, NPPB
1151-cr-edta4510.5ALB, REN
12valsartan45 60 29 1113.5NPPB, REN, ALB
13hhpa4510.5ALB, IGHE
14telmisartan45 29 1112.5NPPB, REN, ALB
15perindopril45 50 1112.5NPPB, REN, ALB
16candesartan45 29 1112.5NPPB, REN, ALB
17enalapril45 50 1112.5NPPB, REN, ALB
18amlodipine45 50 11 2413.5NPPB, REN, ALB
19spironolactone50 45 60 29 1114.5NPPB, REN, ALB
20furosemide45 50 60 29 11 2415.4ALB, REN, NPPB
21indapamide45 1111.4REN, ALB
22captopril45 29 50 60 1114.4NPPB, REN, ALB
23terlipressin45 1111.4ALB, REN
24polyethylene glycol4510.4TNFRSF1A, VTN, ALB, ADA
25losartan45 50 29 1113.4NPPB, REN, SLC22A12, ALB
26urodilatin4510.3NPPB, REN
27latex4510.3PSG2, PRG4, IGHE, VTN
28ivig4510.3TNFRSF1A, TNF, IGHE, ALB
29l-nmma4510.3TNF, NPPB, IGHE
30heparin45 29 11 2413.3VTN, TNFRSF1A
31infliximab45 50 1112.3TNFRSF1A, TNF, IGHE
32prostacyclin4510.3TNFRSF1A, TNF, NPPB, REN, VTN
33tacrolimus45 50 1112.3TNF, NPPB, REN, VTN, ALB
34thyroxine45 2411.3NPPB, IGHE, REN, ALB
35kininogen4510.3REN, VTN, ALB
36hanp4510.2NPPB, REN
37epinephrine45 11 2412.2NPPB, IGHE, REN, VTN, ADA
38methotrexate45 50 1112.2TNFRSF1A, TNF, IGHE, ALB, ADA
39calcitriol45 60 11 2413.2ALB, REN, TNF, TNFRSF1A
40trandolapril45 1111.1REN, NPPB
41pge24510.1TNFRSF1A, TNF, NPPB, REN, VTN
42cyclosporin a45 29 6012.1TNFRSF1A, TNF, NPPB, IGHE, ADA
43neopterin4510.1ADA, TNF, TNFRSF1A
44histamine45 29 2412.1TNF, NPPB, IGHE, HRH4, ALB, ADA
45aspartate4510.1ADA, ALB, VTN, IGHE
46dexamethasone45 50 29 1113.0TNFRSF1A, TNF, NPPB, IGHE, REN, VTN
47bisoprolol45 50 1111.9NPPB, REN
48vegf459.9TNFRSF1A, TNF, NPPB, PSG2, IGHE, REN
49lactate459.8TNF, TNNI3, NPPB, PSG2, IGHE, VTN
50creatinine459.7ADA, TNFRSF1A, TNNI3, NPPB, PSG2, IGHE

GO Terms for genes affiliated with Pericarditis

Sources:
16Gene Ontology
See all sources

Cellular components related to Pericarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.4TNFRSF1A, TNF, NPPB, PSG2, IGHE, REN
2extracellular spaceGO:0056159.2TNFRSF1A, TNF, NPPB, PRG4, REN, VTN

Biological processes related to Pericarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of inflammatory responseGO:05072810.0ADA, MEFV, TNFRSF1A
2inflammatory responseGO:00695410.0HRH4, MEFV, TNF, TNFRSF1A
3regulation of MAPK cascadeGO:0434089.9HRH4, REN

Molecular functions related to Pericarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1polysaccharide bindingGO:03024710.2VTN, PRG4

Products for genes affiliated with Pericarditis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pericarditis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet