MCID: PRC013
MIFTS: 53

Pericarditis malady

Cardiovascular diseases, Rare diseases categories
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Summaries for Pericarditis

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A pericardium disease that is characterized by an inflammation of the pericardium and has symptom chest pain.

MalaCards: Pericarditis is related to constrictive pericarditis and pericardial effusion, and has symptoms including chest pain An important gene associated with Pericarditis is PRG4 (proteoglycan 4), and among its related pathways is IL-9 Signaling Pathways. The compounds niacin and nicotinamide have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and lung, and related mouse phenotypes are skeleton and hematopoietic system.

Wikipedia:65 Pericarditis is an inflammation of the pericardium (the fibrous sac surrounding the heart). A... more...

Aliases & Classifications for Pericarditis

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8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 36MESH via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases


Characteristics (Orphanet epidemiological data):

49
pericarditis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

pericarditis 8 10 45 49 62


External Ids:

Disease Ontology8 DOID:1787
MeSH35 D010493
NCIt40 C34915
SNOMED-CT via Orphanet59 23627006, 3238004
SNOMED-CT58 3238004
UMLS via Orphanet63 C0031046, C0265143
MESH via Orphanet36 D010493
ICD10 via Orphanet26 I30.0, I30.1, I30.8 I30.9, I01.0, more
ICD1025 I32, I32.8

Related Diseases for Pericarditis

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17GeneCards, 18GeneDecks
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Diseases related to Pericarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 303)
idRelated DiseaseScoreTop Affiliating Genes
1constrictive pericarditis31.8NPPB, ADA
2pericardial effusion31.0ADA
3rheumatoid arthritis30.3TNFRSF1A, NAMPT, ADA, PRG4, MEFV
4amyloidosis30.1TNFRSF1A, MEFV, NPPB
5familial mediterranean fever29.9MEFV, TNFRSF1A
6coronary artery disease29.9TNFRSF1A, NPPB
7acute myocardial infarction29.9NPPB, MEFV
8brucellosis29.8MEFV
9behcet's disease29.7MEFV, ADA
10peritonitis29.7MEFV, ADA
11noonan syndrome29.6NPPB, TNFRSF1A
12sepsis29.6TNFRSF1A, NAMPT, NPPB
13diabetes mellitus29.6TNFRSF1A, NAMPT, NPPB
14restrictive cardiomyopathy10.7
15cardiac tamponade10.6
16camptodactyly arthropathy coxa vara pericarditis syndrome10.5
17arthritis10.4
18idiopathic recurrent pericarditis10.4
19myocardial infarction10.4
20pneumonia10.4
21hemopericardium10.4
22myocarditis10.4
23aneurysm10.4
24arthropathy10.3
25endocarditis10.3
26meningitis10.3
27tuberculosis10.3
28protein-losing enteropathy10.3
29chylous ascites10.3
30pericardial mesothelioma10.3
31systemic lupus erythematosus10.3
32hepatitis10.3
33lupus erythematosus10.3
34mediastinitis10.2
35pericardial tuberculosis10.2
36chronic rheumatic pericarditis10.1
37histoplasmosis pericarditis10.1
38aortic aneurysm10.1
39leukemia10.1
40mycobacterium kansasii10.1
41meningococcal meningitis10.1
42dressler's syndrome10.1
43mulibrey nanism10.1
44acute myocarditis10.1
45esophagitis10.1
46influenza10.1
47vasculitis10.1
48gestational diabetes10.1PRG4
49palindromic rheumatism10.1MEFV
50hepatitis c10.0

Graphical network of the top 20 diseases related to Pericarditis:



Diseases related to pericarditis

Symptoms for Pericarditis

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8Disease Ontology
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Symptoms:

8
  • chest pain

Drugs & Therapeutics for Pericarditis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Pericarditis

Search NIH Clinical Center for Pericarditis

Genetic Tests for Pericarditis

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Anatomical Context for Pericarditis

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33MalaCards
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MalaCards organs/tissues related to Pericarditis:

33
Heart, Liver, Lung, Bone, Testes, Bone marrow, Brain, Thyroid, Breast, Kidney, T cells, Myeloid, B cells, Lymph node

Animal Models for Pericarditis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Pericarditis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.2MEFV, PRG4, ADA, TNFRSF1A
2MP:00053978.2MEFV, ADA, NAMPT, TNFRSF1A
3MP:00107687.4TNFRSF1A, NAMPT, ADA, PRG4, MEFV

Publications for Pericarditis

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Sources:
52PubMed
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Articles related to Pericarditis:

(show top 50)    (show all 1000)
idTitleAuthorsYear
1
Cardiac tamponade with community-acquired methicillin-resistant Staphylococcus aureus pericarditis. (23903515)
2013
2
Constrictive pericarditis with a calcific mass invading into the right ventricular myocardium. (23190384)
2013
3
Constrictive pericarditis with intrapericardial abscess. (23207988)
2013
4
Pericarditis, myocarditis, and other cardiomyopathies. (23402470)
2013
5
Percutaneous intrapericardial injection of triamcinolone in a patient with incessant pericarditis: a novel technique. (23148999)
2013
6
Purulent pericarditis caused by a bad tooth. (23344978)
2013
7
Cholesterol pericarditis without active inflammatory change: Evaluation by positron emission tomography and computed tomography. (24155084)
2013
8
Constrictive pericarditis developed after childhood repair of ventricular septal defect. (23910801)
2013
9
Outcome of pericardiectomy for constrictive pericarditis in Japan: a nationwide outcome study. (23791164)
2013
10
Pericardial synovial sarcoma in a dyspnoeic female with tuberculous pericarditis: A case report. (23833678)
2013
11
Mycobacterium kansasii pericarditis in a kidney transplant recipient: a case report and comprehensive review of the literature. (22823928)
2012
12
Clues to detect tumor necrosis factor receptor-associated periodic syndrome (TRAPS) among patients with idiopathic recurrent acute pericarditis: results of a multicentre study. (22311714)
2012
13
IL-33 independently induces eosinophilic pericarditis and cardiac dilation: ST2 improves cardiac function. (22454393)
2012
14
Annular velocities in constrictive pericarditis: annulus and beyond. (21679890)
2011
15
Pneumococcal pneumonia complicating purulent pericarditis in a previously healthy girl: a rare yet possible fatal complication in the antibiotic era. (21822088)
2011
16
Azathioprine in isolated recurrent pericarditis: a single centre experience. (21296434)
2011
17
Constrictive pericarditis with extensive calcification. (21308337)
2011
18
Purulent pericarditis and pericardial abscess one year after LAD-stenting. (21591586)
2011
19
Noninvasive imaging techniques of constrictive pericarditis. (20828356)
2010
20
Recurrent pericarditis caused by a rare mutation in the TNFRSF1A gene and with excellent response to anakinra treatment. (21029567)
2010
21
Pericarditis as a rare complication of pneumococcal pneumonia in a young infant. (20666278)
2010
22
Purulent pericarditis due to Streptococcus pneumoniae diagnosed by pneumococcal urinary antigen assay and 16S rDNA sequence of the pericardial fluid. (20686309)
2010
23
Acute pericarditis and transient erythroblastopenia associated with human parvovirus B19 infection. (21200105)
2010
24
Transient constrictive pericarditis: an elusive diagnosis. (21142635)
2010
25
Hemorrhagic Pericarditis in a child with primary varicella infection (chickenpox). (19332925)
2009
26
Transient constrictive pericarditis diagnosed by cardiac magnetic resonance, 67Ga scintigraphy, and positron emission tomography. (19467563)
2009
27
Purulent pericarditis complicated by cardiac tamponade secondary to a hydatid cyst-associated hepatic abscess. (19706257)
2009
28
Fatal chylous ascites, pericarditis and extensive venous thrombosis, due to an aggressive T cell non-Hodgkin lymphoma. (18679682)
2009
29
Role of echocardiography in the diagnosis of constrictive pericarditis. (19130999)
2009
30
Infective mycotic aneurysm presenting as transient acute coronary occlusion and infectious pericarditis. (19434042)
2009
31
A rare cause of constrictive pericarditis: primary cardiac lymphoma. (17363082)
2008
32
Constrictive pericarditis at abdominal CT: a commonly overlooked diagnosis. (17510764)
2008
33
Tuberculous effusive-constrictive pericarditis. (18776964)
2008
34
Impact of left ventricular function on immediate and long-term outcomes after pericardiectomy in constrictive pericarditis. (19026793)
2008
35
Delayed three-stage closure of giant omphalocele using pericard patch. (17628735)
2008
36
Cystic tuberculous constrictive pericarditis. (17638949)
2007
37
Acute suppurative thyroiditis extending to descending necrotizing mediastinitis and pericarditis. (17381365)
2007
38
Longitudinal mitral annular early diastolic velocities in differentiating effusive constrictive pericarditis from restrictive cardiomyopathy: a case with extreme and straddling variations in regional velocities. (19122257)
2007
39
Adenosine deaminase and tuberculous pericarditis--a systematic review with meta-analysis. (16950165)
2006
40
Magnetic resonance imaging of effusive constrictive pericarditis. (16521660)
2005
41
Constrictive pericarditis following cat-scratch disease in a 12-year-old female: a rare association. (14635359)
2003
42
Constrictive pericarditis caused by calcification and organized hematoma 30 years after cardiac surgery. (12074283)
2002
43
Constrictive pericarditis in the modern era: a diagnostic dilemma. (11711451)
2001
44
Autonomic functions in restrictive cardiomyopathy and constrictive pericarditis: a comparison. (9736135)
1998
45
Images in cardiovascular medicine. Constrictive pericarditis. (9264516)
1997
46
Pericardiectomy after two decades of constrictive pericarditis in a patient with chronic renal failure. (8592610)
1995
47
Hepatic coma as a presenting feature of constrictive pericarditis. (8438853)
1993
48
Clotted hemopericardium with the hemodynamic characteristics of constrictive pericarditis. (7355745)
1980
49
Recognition and treatment of hemopericardium and hemorrhagic pericarditis by pericardiotomy. (13636482)
1959
50
Pericarditis due to a mycotic aneurysm in subacute bacterial endocarditis; report of a case affecting congenitally stenosed quadricuspid aortic valve. (13524719)
1958

Variations for Pericarditis

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Expression for genes affiliated with Pericarditis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pericarditis

Search GEO for disease gene expression data for Pericarditis.

Pathways for genes affiliated with Pericarditis

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50PathCards, 54R&D Systems, 38NCBI BioSystems Database, 60Thomson Reuters, 53QIAGEN
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Pathways related to Pericarditis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.1NAMPT, TNFRSF1A

Compounds for genes affiliated with Pericarditis

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Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 51PharmGKB, 61Tocris Bioscience, 24HMDB, 3BitterDB
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Compounds related to Pericarditis according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1niacin45 1110.8ADA, NAMPT
2nicotinamide45 1110.8ADA, NAMPT
3milrinone45 29 1111.8ADA, NPPB
4cilostazol45 1110.8NPPB, ADA
5allopurinol45 51 1111.8ADA, NPPB
6dipyridamole45 61 29 1112.7ADA, NPPB
7pioglitazone29 45 51 1112.6NPPB, NAMPT
8deoxyguanosine45 2410.6ADA, TNFRSF1A
9vincristine45 51 1111.5NPPB, ADA
10neopterin459.5TNFRSF1A, ADA
11mevalonate459.4MEFV, TNFRSF1A
12polyethylene glycol459.4ADA, TNFRSF1A
13colchicine45 61 3 29 1113.4MEFV, TNFRSF1A
14p005459.3NPPB, TNFRSF1A
15rosiglitazone29 45 51 24 1113.2NPPB, NAMPT
16p003459.2TNFRSF1A, NPPB
17carbachol45 29 1111.1NPPB, ADA
18p002459.0TNFRSF1A, NPPB
19indomethacin45 29 61 1111.9NPPB, ADA, TNFRSF1A
20norepinephrine45 24 1110.9NPPB, ADA, TNFRSF1A
21doxorubicin45 51 1110.9NPPB, ADA, TNFRSF1A
22forskolin45 51 1110.9TNFRSF1A, ADA, NPPB
23cyclosporin a45 29 6110.9NPPB, ADA, TNFRSF1A
24dopamine45 29 24 1111.9NPPB, ADA, TNFRSF1A
25vegf458.7NPPB, ADA, TNFRSF1A
26phosphatidylinositol458.6TNFRSF1A, NAMPT, NPPB
27estrogen458.6NPPB, ADA, TNFRSF1A
28creatinine458.4NPPB, ADA, NAMPT, TNFRSF1A
29dexamethasone45 51 29 1111.4NPPB, ADA, NAMPT, TNFRSF1A

GO Terms for genes affiliated with Pericarditis

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16Gene Ontology
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Cellular components related to Pericarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.6NPPB, PRG4, ADA, NAMPT, TNFRSF1A

Biological processes related to Pericarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to hypoxiaGO:0016669.2ADA, TNFRSF1A
2negative regulation of inflammatory responseGO:0507288.4MEFV, ADA, TNFRSF1A

Products for genes affiliated with Pericarditis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pericarditis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet