MCID: PRC013
MIFTS: 53

Pericarditis malady

Cardiovascular diseases, Rare diseases categories

Summaries for Pericarditis

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A pericardium disease that is characterized by an inflammation of the pericardium and has symptom chest pain.

MalaCards: Pericarditis is related to constrictive pericarditis and pericardial effusion, and has symptoms including chest pain An important gene associated with Pericarditis is PRG4 (proteoglycan 4), and among its related pathways is IL-9 Signaling Pathways. The compounds niacin and nicotinamide have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and lung, and related mouse phenotypes are skeleton and hematopoietic system.

Wikipedia:66 Pericarditis is an inflammation of the pericardium (the fibrous sac surrounding the heart). A... more...

Aliases & Classifications for Pericarditis

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9Disease Ontology, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 37MESH via Orphanet, 27ICD10 via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases


Characteristics (Orphanet epidemiological data):

50
pericarditis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

pericarditis 9 11 46 50 63


External Ids:

Disease Ontology9 DOID:1787
MeSH36 D010493
NCIt41 C34915
SNOMED-CT via Orphanet60 23627006, 3238004
SNOMED-CT59 3238004
UMLS via Orphanet64 C0031046, C0265143
MESH via Orphanet37 D010493
ICD10 via Orphanet27 I30.0, I30.1, I30.8 I30.9, I01.0, more
ICD1026 I32, I32.8

Related Diseases for Pericarditis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Pericarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 303)
idRelated DiseaseScoreTop Affiliating Genes
1constrictive pericarditis31.8NPPB, ADA
2pericardial effusion31.0ADA
3rheumatoid arthritis30.3TNFRSF1A, NAMPT, ADA, PRG4, MEFV
4amyloidosis30.1TNFRSF1A, MEFV, NPPB
5familial mediterranean fever29.9MEFV, TNFRSF1A
6coronary artery disease29.9TNFRSF1A, NPPB
7acute myocardial infarction29.9NPPB, MEFV
8brucellosis29.8MEFV
9behcet's disease29.7MEFV, ADA
10peritonitis29.7MEFV, ADA
11noonan syndrome29.6NPPB, TNFRSF1A
12sepsis29.6TNFRSF1A, NAMPT, NPPB
13diabetes mellitus29.6TNFRSF1A, NAMPT, NPPB
14restrictive cardiomyopathy10.7
15cardiac tamponade10.6
16camptodactyly arthropathy coxa vara pericarditis syndrome10.5
17arthritis10.4
18idiopathic recurrent pericarditis10.4
19myocardial infarction10.4
20pneumonia10.4
21hemopericardium10.4
22myocarditis10.4
23aneurysm10.4
24arthropathy10.3
25endocarditis10.3
26meningitis10.3
27tuberculosis10.3
28protein-losing enteropathy10.3
29chylous ascites10.3
30pericardial mesothelioma10.3
31systemic lupus erythematosus10.3
32hepatitis10.3
33lupus erythematosus10.3
34mediastinitis10.2
35pericardial tuberculosis10.2
36chronic rheumatic pericarditis10.1
37histoplasmosis pericarditis10.1
38aortic aneurysm10.1
39leukemia10.1
40mycobacterium kansasii10.1
41meningococcal meningitis10.1
42dressler's syndrome10.1
43mulibrey nanism10.1
44acute myocarditis10.1
45esophagitis10.1
46influenza10.1
47vasculitis10.1
48gestational diabetes10.1PRG4
49palindromic rheumatism10.1MEFV
50hepatitis c10.0

Graphical network of the top 20 diseases related to Pericarditis:



Diseases related to pericarditis

Symptoms for Pericarditis

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Sources:
9Disease Ontology
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Symptoms:

9
  • chest pain

Drugs & Therapeutics for Pericarditis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Pericarditis

Drug clinical trials:

Search ClinicalTrials for Pericarditis

Search NIH Clinical Center for Pericarditis

Search CenterWatch for Pericarditis

Genetic Tests for Pericarditis

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Anatomical Context for Pericarditis

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Sources:
34MalaCards
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MalaCards organs/tissues related to Pericarditis:

34
Heart, Liver, Lung, Bone, Testes, Bone marrow, Brain, Thyroid, Breast, Kidney, T cells, Myeloid, B cells, Lymph node

Animal Models for Pericarditis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Pericarditis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.2MEFV, PRG4, ADA, TNFRSF1A
2MP:00053978.2MEFV, ADA, NAMPT, TNFRSF1A
3MP:00107687.4TNFRSF1A, NAMPT, ADA, PRG4, MEFV

Publications for Pericarditis

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Sources:
53PubMed
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Articles related to Pericarditis:

(show top 50)    (show all 1000)
idTitleAuthorsYear
1
Cardiac tamponade with community-acquired methicillin-resistant Staphylococcus aureus pericarditis. (23903515)
2013
2
Constrictive pericarditis with a calcific mass invading into the right ventricular myocardium. (23190384)
2013
3
Constrictive pericarditis with intrapericardial abscess. (23207988)
2013
4
Pericarditis, myocarditis, and other cardiomyopathies. (23402470)
2013
5
Percutaneous intrapericardial injection of triamcinolone in a patient with incessant pericarditis: a novel technique. (23148999)
2013
6
Purulent pericarditis caused by a bad tooth. (23344978)
2013
7
Cholesterol pericarditis without active inflammatory change: Evaluation by positron emission tomography and computed tomography. (24155084)
2013
8
Constrictive pericarditis developed after childhood repair of ventricular septal defect. (23910801)
2013
9
Outcome of pericardiectomy for constrictive pericarditis in Japan: a nationwide outcome study. (23791164)
2013
10
Pericardial synovial sarcoma in a dyspnoeic female with tuberculous pericarditis: A case report. (23833678)
2013
11
Mycobacterium kansasii pericarditis in a kidney transplant recipient: a case report and comprehensive review of the literature. (22823928)
2012
12
Clues to detect tumor necrosis factor receptor-associated periodic syndrome (TRAPS) among patients with idiopathic recurrent acute pericarditis: results of a multicentre study. (22311714)
2012
13
IL-33 independently induces eosinophilic pericarditis and cardiac dilation: ST2 improves cardiac function. (22454393)
2012
14
Annular velocities in constrictive pericarditis: annulus and beyond. (21679890)
2011
15
Pneumococcal pneumonia complicating purulent pericarditis in a previously healthy girl: a rare yet possible fatal complication in the antibiotic era. (21822088)
2011
16
Azathioprine in isolated recurrent pericarditis: a single centre experience. (21296434)
2011
17
Constrictive pericarditis with extensive calcification. (21308337)
2011
18
Purulent pericarditis and pericardial abscess one year after LAD-stenting. (21591586)
2011
19
Noninvasive imaging techniques of constrictive pericarditis. (20828356)
2010
20
Recurrent pericarditis caused by a rare mutation in the TNFRSF1A gene and with excellent response to anakinra treatment. (21029567)
2010
21
Pericarditis as a rare complication of pneumococcal pneumonia in a young infant. (20666278)
2010
22
Purulent pericarditis due to Streptococcus pneumoniae diagnosed by pneumococcal urinary antigen assay and 16S rDNA sequence of the pericardial fluid. (20686309)
2010
23
Acute pericarditis and transient erythroblastopenia associated with human parvovirus B19 infection. (21200105)
2010
24
Transient constrictive pericarditis: an elusive diagnosis. (21142635)
2010
25
Hemorrhagic Pericarditis in a child with primary varicella infection (chickenpox). (19332925)
2009
26
Transient constrictive pericarditis diagnosed by cardiac magnetic resonance, 67Ga scintigraphy, and positron emission tomography. (19467563)
2009
27
Purulent pericarditis complicated by cardiac tamponade secondary to a hydatid cyst-associated hepatic abscess. (19706257)
2009
28
Fatal chylous ascites, pericarditis and extensive venous thrombosis, due to an aggressive T cell non-Hodgkin lymphoma. (18679682)
2009
29
Role of echocardiography in the diagnosis of constrictive pericarditis. (19130999)
2009
30
Infective mycotic aneurysm presenting as transient acute coronary occlusion and infectious pericarditis. (19434042)
2009
31
A rare cause of constrictive pericarditis: primary cardiac lymphoma. (17363082)
2008
32
Constrictive pericarditis at abdominal CT: a commonly overlooked diagnosis. (17510764)
2008
33
Tuberculous effusive-constrictive pericarditis. (18776964)
2008
34
Impact of left ventricular function on immediate and long-term outcomes after pericardiectomy in constrictive pericarditis. (19026793)
2008
35
Delayed three-stage closure of giant omphalocele using pericard patch. (17628735)
2008
36
Cystic tuberculous constrictive pericarditis. (17638949)
2007
37
Acute suppurative thyroiditis extending to descending necrotizing mediastinitis and pericarditis. (17381365)
2007
38
Longitudinal mitral annular early diastolic velocities in differentiating effusive constrictive pericarditis from restrictive cardiomyopathy: a case with extreme and straddling variations in regional velocities. (19122257)
2007
39
Adenosine deaminase and tuberculous pericarditis--a systematic review with meta-analysis. (16950165)
2006
40
Magnetic resonance imaging of effusive constrictive pericarditis. (16521660)
2005
41
Constrictive pericarditis following cat-scratch disease in a 12-year-old female: a rare association. (14635359)
2003
42
Constrictive pericarditis caused by calcification and organized hematoma 30 years after cardiac surgery. (12074283)
2002
43
Constrictive pericarditis in the modern era: a diagnostic dilemma. (11711451)
2001
44
Autonomic functions in restrictive cardiomyopathy and constrictive pericarditis: a comparison. (9736135)
1998
45
Images in cardiovascular medicine. Constrictive pericarditis. (9264516)
1997
46
Pericardiectomy after two decades of constrictive pericarditis in a patient with chronic renal failure. (8592610)
1995
47
Hepatic coma as a presenting feature of constrictive pericarditis. (8438853)
1993
48
Clotted hemopericardium with the hemodynamic characteristics of constrictive pericarditis. (7355745)
1980
49
Recognition and treatment of hemopericardium and hemorrhagic pericarditis by pericardiotomy. (13636482)
1959
50
Pericarditis due to a mycotic aneurysm in subacute bacterial endocarditis; report of a case affecting congenitally stenosed quadricuspid aortic valve. (13524719)
1958

Variations for Pericarditis

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Expression for genes affiliated with Pericarditis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pericarditis

Search GEO for disease gene expression data for Pericarditis.

Pathways for genes affiliated with Pericarditis

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Sources:
51PathCards, 55R&D Systems, 39NCBI BioSystems Database, 61Thomson Reuters, 54QIAGEN
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Pathways related to Pericarditis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
9.1NAMPT, TNFRSF1A

Compounds for genes affiliated with Pericarditis

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience, 25HMDB, 3BitterDB
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Compounds related to Pericarditis according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1niacin46 1210.8ADA, NAMPT
2nicotinamide46 1210.8ADA, NAMPT
3milrinone46 30 1211.8ADA, NPPB
4cilostazol46 1210.8NPPB, ADA
5allopurinol46 52 1211.8ADA, NPPB
6dipyridamole46 62 30 1212.7ADA, NPPB
7pioglitazone30 46 52 1212.6NPPB, NAMPT
8deoxyguanosine46 2510.6ADA, TNFRSF1A
9vincristine46 52 1211.5NPPB, ADA
10neopterin469.5TNFRSF1A, ADA
11mevalonate469.4MEFV, TNFRSF1A
12polyethylene glycol469.4ADA, TNFRSF1A
13colchicine46 62 3 30 1213.4MEFV, TNFRSF1A
14p005469.3NPPB, TNFRSF1A
15rosiglitazone30 46 52 25 1213.2NPPB, NAMPT
16p003469.2TNFRSF1A, NPPB
17carbachol46 30 1211.1NPPB, ADA
18p002469.0TNFRSF1A, NPPB
19indomethacin46 30 62 1211.9NPPB, ADA, TNFRSF1A
20norepinephrine46 25 1210.9NPPB, ADA, TNFRSF1A
21doxorubicin46 52 1210.9NPPB, ADA, TNFRSF1A
22forskolin46 52 1210.9TNFRSF1A, ADA, NPPB
23cyclosporin a46 30 6210.9NPPB, ADA, TNFRSF1A
24dopamine46 30 25 1211.9NPPB, ADA, TNFRSF1A
25vegf468.7NPPB, ADA, TNFRSF1A
26phosphatidylinositol468.6TNFRSF1A, NAMPT, NPPB
27estrogen468.6NPPB, ADA, TNFRSF1A
28creatinine468.4NPPB, ADA, NAMPT, TNFRSF1A
29dexamethasone46 52 30 1211.4NPPB, ADA, NAMPT, TNFRSF1A

GO Terms for genes affiliated with Pericarditis

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17Gene Ontology
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Cellular components related to Pericarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.6NPPB, PRG4, ADA, NAMPT, TNFRSF1A

Biological processes related to Pericarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to hypoxiaGO:0016669.2ADA, TNFRSF1A
2negative regulation of inflammatory responseGO:0507288.4MEFV, ADA, TNFRSF1A

Products for genes affiliated with Pericarditis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pericarditis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet