MCID: PRC013
MIFTS: 57

Pericarditis malady

Cardiovascular diseases category

Summaries for Pericarditis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Pericarditis is an inflammation of the pericardium (the fibrous sac surrounding the heart). A... more...

MalaCards: Pericarditis is related to constrictive pericarditis and pericardial effusion, and has symptoms including chest pain An important gene associated with Pericarditis is PRG4 (proteoglycan 4), and among its related pathways are Regulation by c-FLIP and NF-kappaB Signaling. The compounds isoproterenol and indomethacin have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and lung, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A heart disease that is characterized by an inflammation of the pericardium and has symptom chest pain.

Aliases & Classifications for Pericarditis

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8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Characteristics (Orphanet epidemiological data):

48
pericarditis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

pericarditis 8 10 44 48 60


External Ids:

Disease Ontology8 DOID:1787
MeSH34 D010493
NCIt39 C34915
SNOMED-CT via Orphanet57 23627006, 3238004
SNOMED-CT56 3238004
UMLS via Orphanet61 C0031046, C0265143
MESH via Orphanet35 D010493
ICD10 via Orphanet26 I30.0, I30.1, I30.8 I30.9, I01.0, more
ICD1025 I32, I32.8

Related Diseases for Pericarditis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pericarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 329)
idRelated DiseaseScoreTop Affiliating Genes
1constrictive pericarditis31.7ADA, NPPB
2pericardial effusion30.8ADA, PSG2
3arthritis30.6TNFRSF1A, TNF, MEFV, VTN, ALB
4myocardial infarction30.5REN, NPPB, TNNI3
5pneumonia30.5VTN, TNF, PSG2
6myocarditis30.5TNNI3, NPPB
7tuberculosis30.4ADA, ALB, TNF, TNFRSF1A
8rheumatoid arthritis30.4ADA, VTN, MEFV, TNF, TNFRSF1A, PRG4
9meningitis30.4IRAK4, ALB, ADA
10arthropathy30.4PRG4, TNF
11protein-losing enteropathy30.3ALB
12acute myocardial infarction30.3MEFV, NPPB, TNNI3
13systemic lupus erythematosus30.3VTN, ADA, TNFRSF1A, TNF
14influenza30.1ADA
15amyloidosis30.1ALB, MEFV, NPPB, TNFRSF1A
16leukemia30.1TNFRSF1A, TNF, PSG2, ADA
17vasculitis30.1TNF, ALB, MEFV
18pancreatitis30.0ALB
19hepatitis c30.0ALB
20sarcoma29.8ADA
21crohn's disease29.8ALB, TNF
22sarcoidosis29.8ADA, TNF, VTN
23familial mediterranean fever29.8MEFV, TNF, TNFRSF1A
24asthma29.8TNF, HRH4, VTN, IGHE
25kawasaki disease29.6NPPB
26leishmaniasis29.6TNFRSF1A
27cystic fibrosis29.6ALB
28brucellosis29.6MEFV
29dermatomyositis29.6VTN
30hypertrophic cardiomyopathy29.6TNNI3
31nephrotic syndrome29.6VTN, ALB
32pancreatic cancer29.6PSG2, VTN
33glomerulonephritis29.6ALB, VTN
34uveitis29.6TNF, TNFRSF1A
35congestive heart failure29.6REN, TNNI3
36dilated cardiomyopathy29.6TNNI3, NPPB
37adenocarcinoma29.6ADA, VTN, PSG2
38psoriasis29.6VTN, TNF, TNFRSF1A
39behcet's disease29.6TNF, ADA, MEFV
40liver cirrhosis29.6ALB, ADA, REN
41peritonitis29.6ADA, ALB, MEFV, TNF
42myeloma29.6ALB, TNFRSF1A, IGHE, PSG2
43blau syndrome29.6TNF, MEFV
44chronic kidney failure29.6REN, TNNI3, ALB, ADA, VTN, NPPB
45diabetes mellitus29.6NPPB, ALB, TNFRSF1A, TNF, REN, VTN
46restrictive cardiomyopathy10.6
47cardiac tamponade10.6
48camptodactyly arthropathy coxa vara pericarditis syndrome10.4
49hemopericardium10.4
50endocarditis10.3

Graphical network of the top 20 diseases related to Pericarditis:



Diseases related to pericarditis

Clinical Features for Pericarditis

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Sources:
8Disease Ontology
See all sources


Symptoms:

8
  • chest pain

Drugs & Therapeutics for Pericarditis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pericarditis

Drug clinical trials:

Search ClinicalTrials for Pericarditis

Search NIH Clinical Center for Pericarditis

Search CenterWatch for Pericarditis

Genetic Tests for Pericarditis

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Anatomical Context for Pericarditis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Pericarditis:

32
Heart, Liver, Lung, Bone, Testes, Bone marrow, Brain, Thyroid, Breast, Kidney, T cells, Myeloid, B cells, Lymph node

Animal Models for Pericarditis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Pericarditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053879.2TNF, IRAK4, MEFV, IGHE, BATF2, REN
2MP:00053979.1TNFRSF1A, TNF, IRAK4, MEFV, IGHE, REN
3MP:00053768.8ADA, SAR1B, TNFRSF1A, TNF, IRAK4, MEFV
4MP:00107688.7SAR1B, TNFRSF1A, TNF, TNNI3, MEFV, PRG4

Publications for Pericarditis

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Sources:
50PubMed
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Articles related to Pericarditis:

(show top 50)    (show all 1007)
idTitleAuthorsYear
1
Mycobacterium avium-complex pericarditis: a case of unmasking immune reconstitution inflammatory syndrome. (23970640)
2013
2
A new case of idiopathic recurrent acute pericarditis due to R104Q mutation in TNFRSF1A successfully treated with anakinra: expanding the questions. (24295430)
2013
3
A rare case of effusive constrictive cholesterol pericarditis: a case report and review. (23606853)
2013
4
All-in-one case: constrictive pericarditis, secundum atrial septal defect, persistent left superior vena cava and anomalous drainage of hemiazygos vein to coronary sinus. (23443869)
2013
5
Acute pericarditis after percutaneous coronary intervention mimicking inferolateral ST-elevation myocardial infarction. (23388234)
2013
6
Images in clinical medicine. An audible case of acute pericarditis. (23050547)
2012
7
Successful application of a PressureWire retrogradely across an ATS prosthetic aortic valve to diagnose constrictive pericarditis. (22634335)
2012
8
Constrictive pericarditis with ringed calcification along the atrioventricular groove. (22211339)
2012
9
Purulent pericarditis and pericardial abscess one year after LAD-stenting. (21591586)
2011
10
Constrictive pericarditis presenting as chylothorax. (21947162)
2011
11
Colchicine in acute pericarditis: a new standard? (21944143)
2011
12
Recurrent pericarditis caused by a rare mutation in the TNFRSF1A gene and with excellent response to anakinra treatment. (21029567)
2010
13
Chronic constrictive pericarditis. (20734441)
2010
14
Constrictive pericarditis in a renal transplant recipient with tuberculosis. (21072157)
2010
15
Definite and probable septic pericarditis in hemodialysis. (20954978)
2010
16
Pericarditis revealing a relapse of sarcoidosis. (20016441)
2009
17
Infected aortic aneurysm, purulent pericarditis, and pulmonary trunk rupture caused by methicillin-resistant Staphylococcus aureus. (19440821)
2009
18
Calcific constrictive pericarditis with refractory hypokalemia in a patient with Gitelman's syndrome. (19263512)
2009
19
Cardiovascular flashlight. Tuberculous pericarditis with constrictive physiology. (19692393)
2009
20
Diffuse ST segment elevation: what's your diagnosis? Acute pericarditis. (19385371)
2009
21
Recurrent cervical cancer presenting as malignant pericarditis: case report and review of the literature. (19480253)
2009
22
Tuberculous effusive-constrictive pericarditis. (18776964)
2008
23
Pericarditis with cardiac tamponade and addisonian crisis as the presenting features of autoimmune polyglandular syndrome type II: a case series. (18558603)
2008
24
Double-layered calcification with interspacial pericardial effusion in a patient with pericarditis constrictiva calcarea detected by multislice computed tomography. (17323005)
2007
25
Successful treatment of a patient with primary SjAPgren's syndrome complicated with pericarditis during pregnancy. (17634717)
2007
26
Constrictive pericarditis: lessons from the past five years' experience in the South West Cardiothoracic Centre. (17228560)
2006
27
The abdominal aorta and constrictive pericarditis: abdominal aortic respiratory variation as an echocardiographic finding in constrictive pericarditis. (15746723)
2005
28
Constrictive pericarditis due to Coxiella burnetii. (15223458)
2004
29
Pericarditis after meningococcal infection: case report of a child with two distinct episodes. (15014314)
2004
30
Effusive-constrictive pericarditis. (15170943)
2004
31
Effusive-constrictive pericarditis. (15170942)
2004
32
Cardiac failure following group A streptococcal infection with echocardiographically proven pericarditis, still insufficient arguments for acute rheumatic fever: a case report and literature update. (12735424)
2003
33
Fatal outcome of constrictive pericarditis in rheumatoid arthritis. (13680151)
2003
34
Diagnostic value of mitral annular velocity for constrictive pericarditis in the absence of respiratory variation in mitral inflow velocity. (12464913)
2002
35
Does rapid volume loading during transesophageal echocardiography differentiate constrictive pericarditis from restrictive cardiomyopathy? (11926974)
2002
36
Diagnosis of constrictive pericarditis by tagged cine magnetic resonance imaging. (10428666)
1999
37
Fungal purulent constrictive pericarditis in a heart transplant patient. (9647112)
1998
38
Constrictive pericarditis caused by an old hematoma. (9402668)
1997
39
A new classification for pericarditis associated with meningococcal infection. (9266185)
1997
40
Constrictive pericarditis and tuberculosis. (9413497)
1997
41
Radionuclide angiography and magnetic resonance imaging: complementary non-invasive methods in the diagnosis of constrictive pericarditis. (8575480)
1995
42
Tuberculous pericarditis: importance of adenosine deaminase activity in pericardial fluid. (8312671)
1993
43
A case of idiopathic retroperitoneal fibrosis with chronic pericarditis. (1611198)
1992
44
Syndrome of inappropriate antidiuretic hormone secretion secondary to pericarditis. (2338933)
1990
45
Myocardial and endocardial involvement in tuberculous constrictive pericarditis: difficulty in biopsy distinction from endomyocardial fibrosis as a cause of restrictive heart disease. (2394527)
1990
46
Meningism, pericarditis/myocarditis--unrecognized manifestations of acute porphyria. (3097350)
1986
47
Generalized pustular psoriasis with arthritis and pericarditis: case report. (475691)
1979
48
Arbovirus (dengue type) as a cause of acute myocarditis and pericarditis. (4266127)
1973
49
Pericarditis complicating congenital dextrocardia with situs inversus. (5494000)
1970
50
A Case of Adhesive Constrictive Pericarditis (Pick's Disease). (20320608)
1937

Genetic Variations for Pericarditis

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Expression for genes affiliated with Pericarditis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pericarditis

Search GEO for disease gene expression data for Pericarditis.

Pathways for genes affiliated with Pericarditis

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53Reactome, 4Cell Signaling Technology, 29KEGG
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Pathways related to Pericarditis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2TNF, TNFRSF1A
210.1IRAK4, TNF, TNFRSF1A
310.1IRAK4, TNF, TNFRSF1A

Compounds for genes affiliated with Pericarditis

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Pericarditis according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1isoproterenol44 1111.7ADA
2indomethacin44 59 28 1113.7REN, NPPB
3ornipressin4410.6REN, ALB
4alacepril4410.6NPPB, REN
5prednisolone44 28 1112.6NPPB, IGHE
6norepinephrine44 11 2412.5TNFRSF1A, IGHE
7fosinopril44 1111.5ALB, REN, NPPB
8lisinopril44 11 2412.5REN, NPPB, ALB
9darusentan44 2811.5NPPB, REN
10ramipril44 1111.5NPPB, ALB, REN
1151-cr-edta4410.5REN, ALB
12valsartan44 59 28 1113.5REN, ALB, NPPB
13hhpa4410.5IGHE, ALB
14telmisartan44 28 1112.5REN, NPPB, ALB
15perindopril44 49 1112.5NPPB, REN, ALB
16candesartan44 28 1112.5REN, NPPB, ALB
17enalapril44 49 1112.5REN, NPPB, ALB
18amlodipine44 49 11 2413.5NPPB, REN, ALB
19spironolactone49 44 59 28 1114.5ALB, REN, NPPB
20furosemide44 49 59 28 11 2415.4NPPB, REN, ALB
21indapamide44 1111.4REN, ALB
22captopril44 28 49 59 1114.4NPPB, REN, ALB
23terlipressin44 1111.4REN, ALB
24polyethylene glycol4410.4ADA, TNFRSF1A, VTN, ALB
25losartan44 49 28 1113.4ALB, REN, SLC22A12, NPPB
26urodilatin4410.3NPPB, REN
27latex4410.3PSG2, IGHE, VTN, PRG4
28ivig4410.3IGHE, TNFRSF1A, TNF, ALB
29infliximab44 49 1112.3TNFRSF1A, TNF, IGHE
30heparin44 28 11 2413.3TNFRSF1A, VTN
31l-nmma4410.3TNF, IGHE, NPPB
32prostacyclin4410.3NPPB, TNFRSF1A, TNF, REN, VTN
33tacrolimus44 49 1112.3ALB, VTN, TNF, REN, NPPB
34thyroxine44 2411.3ALB, REN, IGHE, NPPB
35kininogen4410.3VTN, ALB, REN
36bisoprolol44 49 1112.2REN, NPPB
37epinephrine44 11 2412.2VTN, NPPB, IGHE, REN, ADA
38methotrexate44 49 1112.2TNFRSF1A, ADA, IGHE, TNF, ALB
39calcitriol44 59 11 2413.2TNFRSF1A, TNF, REN, ALB
40trandolapril44 1111.1REN, NPPB
41pge24410.1TNF, VTN, REN, NPPB, TNFRSF1A
42cyclosporin a44 28 5912.1TNF, ADA, IGHE, TNFRSF1A, NPPB
43neopterin4410.1TNF, TNFRSF1A, ADA
44histamine44 28 2412.1HRH4, NPPB, TNF, ADA, ALB, IGHE
45aspartate4410.1VTN, ALB, ADA, IGHE
46dexamethasone44 49 28 1113.0IGHE, NPPB, ADA, VTN, TNFRSF1A, TNF
47hanp449.9NPPB, REN
48vegf449.9NPPB, PSG2, IGHE, ADA, REN, TNFRSF1A
49lactate449.8IGHE, TNNI3, PSG2, VTN, ALB, ADA
50creatinine449.7ALB, PSG2, IGHE, TNNI3, SLC22A12, TNFRSF1A

GO Terms for genes affiliated with Pericarditis

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16Gene Ontology
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Cellular components related to Pericarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.4TNF, NPPB, PSG2, IGHE, REN, VTN
2extracellular spaceGO:0056159.2ADA, TNFRSF1A, TNF, NPPB, PRG4, REN

Biological processes related to Pericarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of inflammatory responseGO:05072810.0ADA, MEFV, TNFRSF1A
2inflammatory responseGO:00695410.0HRH4, MEFV, TNF, TNFRSF1A
3regulation of MAPK cascadeGO:0434089.9HRH4, REN

Molecular functions related to Pericarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1polysaccharide bindingGO:03024710.2VTN, PRG4

Products for genes affiliated with Pericarditis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pericarditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet