MCID: PRC013
MIFTS: 57

Pericarditis malady

Cardiovascular diseases category

Summaries for Pericarditis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Pericarditis is an inflammation of the pericardium (the fibrous sac surrounding the heart). A... more...

MalaCards: Pericarditis is related to constrictive pericarditis and pericardial effusion, and has symptoms including chest pain An important gene associated with Pericarditis is PRG4 (proteoglycan 4), and among its related pathways are Regulation by c-FLIP and NF-kappaB Signaling. The compounds isoproterenol and indomethacin have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and lung, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A heart disease that is characterized by an inflammation of the pericardium and has symptom chest pain.

Aliases & Classifications for Pericarditis

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8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Characteristics (Orphanet epidemiological data):

48
pericarditis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

pericarditis 8 10 44 48 60


External Ids:

Disease Ontology8 DOID:1787
MeSH34 D010493
NCIt39 C34915
SNOMED-CT via Orphanet57 23627006, 3238004
SNOMED-CT56 3238004
UMLS via Orphanet61 C0031046, C0265143
MESH via Orphanet35 D010493
ICD10 via Orphanet26 I30.0, I30.1, I30.8 I30.9, I01.0, more
ICD1025 I32, I32.8

Related Diseases for Pericarditis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pericarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 329)
idRelated DiseaseScoreTop Affiliating Genes
1constrictive pericarditis31.7ADA, NPPB
2pericardial effusion30.8ADA, PSG2
3arthritis30.6TNFRSF1A, TNF, MEFV, VTN, ALB
4myocardial infarction30.5REN, NPPB, TNNI3
5pneumonia30.5VTN, TNF, PSG2
6myocarditis30.5TNNI3, NPPB
7tuberculosis30.4ADA, ALB, TNF, TNFRSF1A
8rheumatoid arthritis30.4ADA, VTN, MEFV, TNF, TNFRSF1A, PRG4
9meningitis30.4IRAK4, ALB, ADA
10arthropathy30.4PRG4, TNF
11protein-losing enteropathy30.3ALB
12acute myocardial infarction30.3MEFV, NPPB, TNNI3
13systemic lupus erythematosus30.3VTN, ADA, TNFRSF1A, TNF
14influenza30.1ADA
15amyloidosis30.1ALB, MEFV, NPPB, TNFRSF1A
16leukemia30.1TNFRSF1A, TNF, PSG2, ADA
17vasculitis30.1TNF, ALB, MEFV
18pancreatitis30.0ALB
19hepatitis c30.0ALB
20sarcoma29.8ADA
21crohn's disease29.8ALB, TNF
22sarcoidosis29.8ADA, TNF, VTN
23familial mediterranean fever29.8MEFV, TNF, TNFRSF1A
24asthma29.8TNF, HRH4, VTN, IGHE
25kawasaki disease29.6NPPB
26leishmaniasis29.6TNFRSF1A
27cystic fibrosis29.6ALB
28brucellosis29.6MEFV
29dermatomyositis29.6VTN
30hypertrophic cardiomyopathy29.6TNNI3
31nephrotic syndrome29.6VTN, ALB
32pancreatic cancer29.6PSG2, VTN
33glomerulonephritis29.6ALB, VTN
34uveitis29.6TNF, TNFRSF1A
35congestive heart failure29.6REN, TNNI3
36dilated cardiomyopathy29.6TNNI3, NPPB
37adenocarcinoma29.6ADA, VTN, PSG2
38psoriasis29.6VTN, TNF, TNFRSF1A
39behcet's disease29.6TNF, ADA, MEFV
40liver cirrhosis29.6ALB, ADA, REN
41peritonitis29.6ADA, ALB, MEFV, TNF
42myeloma29.6ALB, TNFRSF1A, IGHE, PSG2
43blau syndrome29.6TNF, MEFV
44chronic kidney failure29.6REN, TNNI3, ALB, ADA, VTN, NPPB
45diabetes mellitus29.6NPPB, ALB, TNFRSF1A, TNF, REN, VTN
46restrictive cardiomyopathy10.6
47cardiac tamponade10.6
48camptodactyly arthropathy coxa vara pericarditis syndrome10.4
49hemopericardium10.4
50endocarditis10.3

Graphical network of the top 20 diseases related to Pericarditis:



Diseases related to pericarditis

Clinical Features for Pericarditis

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Sources:
8Disease Ontology
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Symptoms:

8
  • chest pain

Drugs & Therapeutics for Pericarditis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pericarditis

Drug clinical trials:

Search ClinicalTrials for Pericarditis

Search NIH Clinical Center for Pericarditis

Search CenterWatch for Pericarditis

Genetic Tests for Pericarditis

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Anatomical Context for Pericarditis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Pericarditis:

32
Heart, Liver, Lung, Bone, Testes, Bone marrow, Thyroid, Breast, Kidney, Brain, Myeloid, T cells, B cells, Lymph node

Animal Models for Pericarditis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Pericarditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053879.2TNF, IRAK4, MEFV, IGHE, BATF2, REN
2MP:00053979.1TNFRSF1A, TNF, IRAK4, MEFV, IGHE, REN
3MP:00053768.8ADA, SAR1B, TNFRSF1A, TNF, IRAK4, MEFV
4MP:00107688.7SAR1B, TNFRSF1A, TNF, TNNI3, MEFV, PRG4

Publications for Pericarditis

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Sources:
50PubMed
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Articles related to Pericarditis:

(show top 50)    (show all 1007)
idTitleAuthorsYear
1
Comment on: Idiopathic pericarditis presenting large hemorrhagic pericardial effusion. (24342413)
2014
2
New Electrocardiographic Criteria to Differentiate Acute Pericarditis and Myocardial Infarction. (24287008)
2013
3
Axial involvement with facet joint arthropathy and bony ankylosis in a case of camptodactyly, arthropathy, coxa vara, pericarditis (CACP) syndrome. (23931850)
2013
4
Recurrent pericarditis in Myhre syndrome. (23610053)
2013
5
A 10-month-old with Lemierre syndrome complicated by purulent pericarditis. (22809766)
2013
6
A stone miner with both silicosis and constrictive pericarditis: case report and review of the literature. (24314106)
2013
7
Mechanism of septal bounce in constrictive pericarditis: a simultaneous cardiac catheterisation and echocardiographic study. (23740298)
2013
8
Treatment with aspirin, NSAID, corticosteroids, and colchicine in acute and recurrent pericarditis. (22661042)
2013
9
Brucellosis presenting with pericarditis: case report and literature review. (23401813)
2013
10
Purulent pericarditis and cardiac tamponade caused by Nocardia farcinica in a nephrotic syndrome patient. (24088757)
2013
11
Intravenous immunoglobulin therapy leading to dramatic improvement in a patient with systemic juvenile idiopathic arthritis and severe pericarditis resistant to steroid pulse therapy. (20237928)
2012
12
Bacterial pericarditis caused by Lactobacillus iners in an infant. (22818098)
2012
13
Pneumococcal pneumonia complicating purulent pericarditis in a previously healthy girl: a rare yet possible fatal complication in the antibiotic era. (21822088)
2011
14
The case a8L Multiple-organ failure in a dialysis patient with pericarditis. (21918564)
2011
15
Risk of constrictive pericarditis after acute pericarditis. (21844077)
2011
16
Blunt trauma as a suspected cause of delayed constrictive pericarditis: a case report. (21345214)
2011
17
Pleiotropic effects of transforming growth factor-I^1 on pericardial interstitial cells. Implications for fibrosis and calcification in idiopathic constrictive pericarditis. (21474044)
2011
18
Successful management of Listeria monocytogenes pericarditis: case report and review of the literature. (21894816)
2011
19
Recurrent pericarditis in a patient with ulcerative proctitis due to mesalazine suppositories. (20237787)
2010
20
Acute pericarditis induced stress cardiomyopathy. (20666280)
2010
21
Infective mycotic aneurysm presenting as transient acute coronary occlusion and infectious pericarditis. (19434042)
2009
22
Effusive constrictive pericarditis: functional and anatomical magnetic resonance findings. (19224933)
2009
23
Spontaneous bacterial pericarditis with tamponade due to Ureaplasma spp. (19386833)
2009
24
Constrictive pericarditis, still a diagnostic challenge: comprehensive review of clinical management. (19394850)
2009
25
Commentary on "A case of acute cardiomyopathy and pericarditis associated with methylphenidate"; Cardiovasc Toxicol, DOI 10.1007/s12012-009-9033-7. (19415530)
2009
26
Post-operative mediastinitis, pleuritis and pericarditis due to Mycoplasma hominis and Ureaplasma urealyticum with a fatal outcome. (18436601)
2008
27
Cardiac tamponade secondary to methicillin-resistant Staphylococcus aureus pericarditis. (18959091)
2008
28
Constrictive pericarditis as an emerging manifestation of hyper-IgG4 disease. (17727980)
2008
29
Bacterial pericarditis presenting as hemorrhagic pericardial effusion in a 6-year-old girl. (20300244)
2008
30
Pericarditis heralding Erdheim-Chester disease. (18824648)
2008
31
Pericardial synovial sarcoma mimicking pericarditis in findings of cardiac magnetic resonance imaging. (17399807)
2007
32
Chest pain resulting from histoplasmosis pericarditis: a brief report and review of the literature. (16924162)
2006
33
Constrictive pericarditis versus restrictive cardiomyopathy: challenges in diagnosis and management. (15476569)
2004
34
Constrictive pericarditis and pleuropulmonary fibrosis secondary to cabergoline treatment for Parkinson's disease. (15253989)
2004
35
Cardiac tamponade rapidly evolving toward constrictive pericarditis and shock as a first manifestation of noncardiac cancer. (15016049)
2004
36
Constrictive pericarditis following a pyopericardium due to Staphylococcus aureus. (17670141)
2003
37
Chronic eosinophilic pneumonia presenting with pericarditis and ventricular wall hypertrophy. (12559551)
2003
38
The use of adenosine deaminase and interferon-gamma as diagnostic tools for tuberculous pericarditis. (12226030)
2002
39
Constrictive pericarditis associated with Marlex mesh. Two case reports. (11330746)
2001
40
Calcific constrictive pericarditis. (11074918)
2000
41
A 43-year-old man with a large recurrent right-sided pleural effusion. Diagnosis: Constrictive pericarditis. (10767259)
2000
42
Relevance of adenosine deaminase and lysozyme measurements in the diagnosis of tuberculous pericarditis. (11173777)
2000
43
Chronic constrictive pericarditis induced by long-term bromocriptine therapy: report of two cases. (10534217)
1999
44
Autonomic functions in restrictive cardiomyopathy and constrictive pericarditis: a comparison. (9736135)
1998
45
Massive pericardial hematoma simulating constrictive pericarditis: a complication of radiofrequency catheter ablation. (9535464)
1998
46
Constrictive pericarditis in B cell chronic lymphatic leukaemia. (8866146)
1996
47
The differentiation of restrictive cardiomyopathy from constrictive pericarditis. (2249220)
1990
48
Differentiation of constrictive pericarditis and restrictive cardiomyopathy by radionuclide ventriculography. (2741778)
1989
49
Asthma, eosinophilic pleuropneumonia, and pericarditis without vasculitis. (3787538)
1986
50
Chronic constrictive pericarditis (Pick's disease). (13959790)
1962

Genetic Variations for Pericarditis

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Expression for genes affiliated with Pericarditis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pericarditis

Search GEO for disease gene expression data for Pericarditis.

Pathways for genes affiliated with Pericarditis

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Sources:
53Reactome, 4Cell Signaling Technology, 29KEGG
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Pathways related to Pericarditis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2TNF, TNFRSF1A
210.1IRAK4, TNF, TNFRSF1A
310.1IRAK4, TNF, TNFRSF1A

Compounds for genes affiliated with Pericarditis

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Pericarditis according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1isoproterenol44 1111.7ADA
2indomethacin44 59 28 1113.7NPPB, REN
3ornipressin4410.6ALB, REN
4alacepril4410.6NPPB, REN
5prednisolone44 28 1112.6IGHE, NPPB
6norepinephrine44 11 2412.5IGHE, TNFRSF1A
7fosinopril44 1111.5ALB, REN, NPPB
8lisinopril44 11 2412.5ALB, REN, NPPB
9darusentan44 2811.5REN, NPPB
10ramipril44 1111.5ALB, REN, NPPB
1151-cr-edta4410.5ALB, REN
12valsartan44 59 28 1113.5NPPB, REN, ALB
13hhpa4410.5ALB, IGHE
14telmisartan44 28 1112.5NPPB, REN, ALB
15perindopril44 49 1112.5NPPB, REN, ALB
16candesartan44 28 1112.5NPPB, REN, ALB
17enalapril44 49 1112.5NPPB, REN, ALB
18amlodipine44 49 11 2413.5NPPB, REN, ALB
19spironolactone49 44 59 28 1114.5NPPB, REN, ALB
20furosemide44 49 59 28 11 2415.4ALB, REN, NPPB
21indapamide44 1111.4REN, ALB
22captopril44 28 49 59 1114.4NPPB, REN, ALB
23terlipressin44 1111.4ALB, REN
24polyethylene glycol4410.4TNFRSF1A, VTN, ALB, ADA
25losartan44 49 28 1113.4NPPB, REN, SLC22A12, ALB
26urodilatin4410.3NPPB, REN
27latex4410.3PSG2, PRG4, IGHE, VTN
28ivig4410.3TNFRSF1A, TNF, IGHE, ALB
29l-nmma4410.3TNF, NPPB, IGHE
30heparin44 28 11 2413.3VTN, TNFRSF1A
31infliximab44 49 1112.3TNFRSF1A, TNF, IGHE
32prostacyclin4410.3TNFRSF1A, TNF, NPPB, REN, VTN
33tacrolimus44 49 1112.3TNF, NPPB, REN, VTN, ALB
34thyroxine44 2411.3NPPB, IGHE, REN, ALB
35kininogen4410.3REN, VTN, ALB
36hanp4410.2NPPB, REN
37epinephrine44 11 2412.2NPPB, IGHE, REN, VTN, ADA
38methotrexate44 49 1112.2TNFRSF1A, TNF, IGHE, ALB, ADA
39calcitriol44 59 11 2413.2ALB, REN, TNF, TNFRSF1A
40trandolapril44 1111.1REN, NPPB
41pge24410.1TNFRSF1A, TNF, NPPB, REN, VTN
42cyclosporin a44 28 5912.1TNFRSF1A, TNF, NPPB, IGHE, ADA
43neopterin4410.1ADA, TNF, TNFRSF1A
44histamine44 28 2412.1TNF, NPPB, IGHE, HRH4, ALB, ADA
45aspartate4410.1ADA, ALB, VTN, IGHE
46dexamethasone44 49 28 1113.0TNFRSF1A, TNF, NPPB, IGHE, REN, VTN
47bisoprolol44 49 1111.9NPPB, REN
48vegf449.9TNFRSF1A, TNF, NPPB, PSG2, IGHE, REN
49lactate449.8TNF, TNNI3, NPPB, PSG2, IGHE, VTN
50creatinine449.7ADA, TNFRSF1A, TNNI3, NPPB, PSG2, IGHE

GO Terms for genes affiliated with Pericarditis

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Sources:
16Gene Ontology
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Cellular components related to Pericarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.4TNFRSF1A, TNF, NPPB, PSG2, IGHE, REN
2extracellular spaceGO:0056159.2TNFRSF1A, TNF, NPPB, PRG4, REN, VTN

Biological processes related to Pericarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of inflammatory responseGO:05072810.0ADA, MEFV, TNFRSF1A
2inflammatory responseGO:00695410.0HRH4, MEFV, TNF, TNFRSF1A
3regulation of MAPK cascadeGO:0434089.9HRH4, REN

Molecular functions related to Pericarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1polysaccharide bindingGO:03024710.2VTN, PRG4

Products for genes affiliated with Pericarditis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pericarditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet