Pericarditis malady

Wikipedia: Pericarditis is an inflammation of the pericardium (the fibrous sac surrounding the heart). A...⁴⁴ more...

MalaCards: Pericarditis is related to constrictive pericarditis and camptodactyly-arthropathy-coxa vara-pericarditis syndrome, and has symptoms including chest pain An important gene associated with Pericarditis is PRG4 (proteoglycan 4), and among its related pathways are Bacterial infections in CF airways and Graft-versus-host disease. The compounds gamma globulin and n acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and liver, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology: A heart disease that is characterized by an inflammation of the pericardium and has symptom chest pain.⁶

Aliases & Descriptions:

pericarditis 6 8 32 43

Diseases related to pericarditis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 658)

id	Related Disease	Score	Top Affiliating Genes
1	constrictive pericarditis	34.0	NPPB, ADA
2	camptodactyly-arthropathy-coxa vara-pericarditis syndrome	33.5	VTN, PRG4
3	cardiac tamponade	29.0	HSPG2, CRP, PSG2, ADA
4	pericardial effusion	28.6	PIK3C2A, CEACAM3, ALB, TNNI3, PSG2, ADA
5	hepatitis	28.4	IFNA2, ALB, TNFRSF1A, SLC17A5
6	familial mediterranean fever	27.6	MEFV, TNF, TNFRSF1A
7	hepatitis c	27.4	IL2, IFNA2, TNF, SLC17A5
8	end stage renal failure	26.2	IL6, ALB, TNF, CRP, NPPB, ADA
9	chronic kidney failure	26.2	REN, VTN, IL6, ALB, TNNI3, CRP
10	arthropathy	26.0	VTN, IL1B, IL2, IL6, IL8, HSPG2
11	congestive heart failure	25.2	PIK3C2A, REN, IL6, ALB, TNF, TNNI3
12	sjogren's syndrome	23.8	PIK3C2A, SAR1B, IL1B, IL2, IL6, ALB
13	neuronitis	19.8	PIK3C2A, REN, CEACAM3, IL1B, IL6, IL8
14	miliary tuberculosis	13.6	IGHE, ALB, ADA
15	abdominal tuberculosis	13.5	ALB, ADA
16	high blood pressure	13.5	REN, ALB, NPPB
17	acute diarrhea	13.4	IGHE, ALB, G6PD
18	abcb11-related intrahepatic cholestasis	13.4	PIK3C2A, REN, NPPB
19	orthostatic hypotension	13.4	REN, ALB, G6PD
20	membranous glomerulonephritis	13.3	VTN, ALB, HSPG2
21	hypomagnesemia	13.3	REN, ALB, CRP
22	familial cold autoinflammatory syndrome	13.2	MEFV, IL1B, TNFRSF1A
23	omenn syndrome	13.2	IGHE, TNF, ADA
24	mononeuritis	13.2	HSPG2, CRP
25	hepatorenal syndrome	13.2	REN, ALB, TNF
26	gas gangrene	13.2	PIK3C2A, HSPG2, TNNI3
27	periodic fever, familial, autosomal dominant	13.2	MEFV, TNF, TNFRSF1A
28	bilirubin metabolic disorder	13.1	ALB, G6PD, SLC17A5
29	extrapulmonary tuberculosis	13.1	IL1B, CRP, ADA
30	renovascular hypertension	13.1	REN, ALB, TNF, NPPB
31	erysipelas	13.1	PIK3C2A, MEFV, TNF
32	obstructive lung disease	13.0	REN, IGHE, ALB, TNF
33	portal vein thrombosis	13.0	REN, IFNA2, ALB, CRP
34	21-hydroxylase deficiency	13.0	VTN, IFNA2, SLC17A5
35	vibrio vulnificus infection	13.0	PIK3C2A, IL6
36	central nervous system leukemia	13.0	IL1B, TNF
37	t-lymphocytopenia	13.0	IL2, ALB, CRP
38	galactosemia	13.0	PIK3C2A, VTN, ALB, SLC17A5
39	hydrops of gallbladder	13.0	PIK3C2A, MEFV, ALB, TNFRSF1A, NPPB
40	hydrops fetalis	13.0	ALB, G6PD, SLC17A5
41	bile duct cancer	13.0	CEACAM3, IL6, PSG2
42	syncope	13.0	PIK3C2A, REN, TNNI3, G6PD, NPPB
43	pleural tuberculosis	13.0	IL8, PSG2, ADA
44	hyperphosphatemia	13.0	ALB, CRP, SLC17A5
45	typhus	13.0	CRP, G6PD, SLC17A5
46	hyper-igd syndrome	13.0	TNF, TNFRSF1A, CRP
47	oral tuberculosis	13.0	IL2, TNF
48	duchenne muscular dystrophy	13.0	PIK3C2A, HSPG2, TNNI3, NPPB, ADA
49	bronchiolitis obliterans organizing pneumonia	12.9	PIK3C2A, IFNA2, ALB, CRP
50	staphylococcal toxic shock syndrome	12.9	IL1B, IGHE, TNF

Symptoms: chest pain.⁶

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to pericarditis:

²²

MGI Mouse Phenotypes related to pericarditis:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.6	ADA, SLC22A12, IGHE, MEFV, IRAK4
2	immune system phenotype	MP:0005387	7.6	TNFRSF1A, TNF, HSPG2, IL6, IL2, MEFV
3	homeostasis/metabolism phenotype	MP:0005376	6.6	PIK3C2A, ADA, SLC17A5, SLC22A12, DNM1, G6PD
4	cardiovascular system phenotype	MP:0005385	6.0	CRP, G6PD, PRG4, NPPB, SLC22A12, TNNI3
5	mortality/aging	MP:0010768	5.3	TNF, TNFRSF1A, TNNI3, G6PD, DNM1, SLC22A12

Articles related to pericarditis:

(show all 43)

id	Title	Authors	Year	Affiliating Genes
1	Prevalence of C-reactive protein elevation and time c ourse of normalization in acute pericarditis: implications for the diagnosis, t herapy, and prognosis of pericarditis. (21357824)	Imazio M.... Trinchero R.	2011	CRP
2	A novel deletion mutation in proteoglycan-4 underlies camptodactyly-arthropathy-coxa-vara-pericarditis syndrome in a consanguineous pakistani family. (21565623)	Basit S.... Ahmad W.	2011	PRG4
3	Histamine in pericarditis of children with congenital heart malformations. (20012759)	MasliA8ska D.... MasliA8ski S.	2010	TPT1, HRH4
4	Recurrent pericarditis caused by a rare mutation in t he TNFRSF1A gene and with excellent response to anakinra treatment. (21029567)	Cantarini L.... Galeazzi M.	2010	TNFRSF1A
5	Familial clustering of recurrent pericarditis may dis close tumour necrosis factor receptor-associated periodic syndrome. (20497634)	Cantarini L.... Galeazzi M.	2010	TNFRSF1A
6	Idiopathic recurrent pericarditis refractory to colch icine treatment can reveal tumor necrosis factor receptor-associated periodic s yndrome. (20074469)	Cantarini L.... Galeazzi M.	2009	TNF, TNFRSF1A, MEFV
7	A case of cardiac tamponade caused by tuberculous pericarditis. (19155666)	AvA9ar A.... Melek M.	2008	ADA
8	Staphylococcal pericarditis, and liver and paratracheal abscesses as presentations in two new cases of interleukin-1 receptor associated kinase 4 deficiency. (18174872)	Comeau J.L.... Issekutz A.C.	2008	TNF, IL6, IRAK4
9	The usefulness of adenosine deaminase in the diagnosis of tuberculous pericarditis. (17625694)	Tuon F.F.... Ho Y.L.	2007	ADA
10	Utility of BNP in differentiating constrictive pericarditis from restrictive cardiomyopathy in patients with renal insufficiency. (17923360)	Reddy P.R.... Leya F.S.	2007	NPPB
11	Pegylated interferon treatment of acute pericarditis associated with acute hepatitis C. (18080927)	Kocaman O.... HA1lagA1 S.	2007	SLC17A5
12	Successful treatment of a patient with primary SjAPgre n's syndrome complicated with pericarditis during pregnancy. (17634717)	Mutsukura K.... Eguchi K.	2007	CRP
13	Diagnosing tuberculous pericarditis. (17121764)	Reuter H.... Doubell A.	2006	ADA
14	Adenosine deaminase and tuberculous pericarditis--a systematic review with meta-analysis. (16950165)	Tuon F.F.... Lopes M.I.	2006	ADA
15	A case of systemic sclerosis and Sjogren's syndrome with cardiac tamponade due to steroid-responsive pericarditis (16883110)	Sato T.... Akiyama O.	2006	HSPG2
16	Brain natriuretic peptide levels in constrictive pericarditis and restrictive cardiomyopathy. (16580543)	Babuin L.... Jaffe A.S.	2006	NPPB
17	B-type natriuretic peptide level in a patient with co nstrictive pericarditis. (17086538)	Brown T.... Hollman J.	2006	NPPB
18	Tuberculous pericarditis. (16330703)	Mayosi B.M.... Doubell A.F.	2005	ADA
19	Synovial pathology in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. (15702367)	Shayan K.... Thorner P.S.	2005	PRG4
20	Idiopathic recurrent acute pericarditis: familial Mediterranean fever mutations and disease evolution in a large cohort of Caucasian patients. (16218464)	Brucato A.... Livneh A.	2005	MEFV
21	The efficacy of brain natriuretic peptide levels in differentiating constrictive pericarditis from restrictive cardiomyopathy. (15936624)	Leya F.S.... Cho L.	2005	NPPB
22	Adenosine deaminase activity--more than a diagnostic tool in tuberculous pericarditis. (16049586)	Reuter H.... Doubell A.F.	2005	ADA
23	Pericarditis due to interferon-alpha therapy during treatment for chronic hepatitis C. (15587340)	Gressens B.... Gohy P.	2004	IFNA2
24	A case of tuberculous pericarditis, the diagnosis of which was complicated by the delay in the rise of adenosine deaminase in the pericardial effusion (12806984)	Yano S.... Saito S.	2003	ADA
25	Cytokine production in patients with tuberculous pericarditis. (12019920)	Burgess L.J.... Doubell A.F.	2002	IL2
26	Comparison of polymerase chain reaction with adenosine deaminase activity in pericardial fluid for the diagnosis of tuberculous pericarditis. (12427503)	Lee J.H.... Park S.J.	2002	ADA
27	The use of adenosine deaminase and interferon-gamma as diagnostic tools for tuberculous pericarditis. (12226030)	Burgess L.J.... Doubell A.F.	2002	ADA
28	A case of acute recurrent benign pericarditis in a patient with glucose-6-phosphate dehydrogenase deficiency, treated with sodium salicylate (10920507)	Tedeschini R.C.... Poggesi L.	2000	G6PD
29	Cytokine activation in pericardial fluids in different forms of pericarditis. (11200123)	Pankuweit S.... Maisch B.	2000	IL8
30	Relevance of adenosine deaminase and lysozyme measurements in the diagnosis of tuberculous pericarditis. (11173777)	Aggeli C.... Toutouzas P.	2000	ADA
31	CACP, encoding a secreted proteoglycan, is mutated in camptodactyly- arthropathy-coxa vara-pericarditis syndrome. (10545950)	Marcelino J.... Warman M.L.	1999	VTN, PRG4
32	The camptodactyly-arthropathy-coxa vara-pericarditis syndrome: clinical features and genetic mapping to human chromosome 1. (9550484)	Bahabri S.A.... Warman M.L.	1998	PRG4
33	The role of carcinoembryonic antigen (CEA) and neuron-specific enolase (NSE) evaluation in pericardial fluid for the recognition of malignant pericarditis. (9479590)	Szturmowicz M.... Filipecki S.	1997	PSG2
34	Neuroendocrine response to standing and mild exercise in patients with untreated severe congestive heart failure and chronic constrictive pericarditis. (8774327)	Ferrari R.... Harris P.	1996	REN
35	A case of effusive-constrictive pericarditis and its surgical treatment (8741457)	Hayashi K.... Suma K.	1996	ADA
36	The diagnostic and prognostic value of adenosine deaminase in tuberculous pericarditis. (8665976)	KomsuoA9lu B.... KomsuoA9lu S.S.	1995	ADA
37	Adenosine deaminase and carcinoembryonic antigen in pericardial effusion diagnosis, especially in suspected tuberculous pericarditis. (8205688)	Koh K.K.... Kim J.M.	1994	ADA, CEACAM3
38	Surgical intervention to tuberculous pericarditis: a case report (7967260)	Saitoh H.... Nagao K.	1994	ADA
39	Tuberculous pericarditis: importance of adenosine deaminase activity in pericardial fluid. (8312671)	Inoue T.... Iwata T.	1993	ADA
40	Tuberculous pericarditis: value of adenosine deaminase activity level assessment (1439386)	Letiexhe M.... Kulbertus H.	1992	ADA
41	Tuberculous pericarditis: diagnostic value of adenosine deaminase (1828568)	Telenti M.... Moreno Torrico A.	1991	ADA
42	Constrictive pericarditis without typical haemodynami c changes as a cause of oedema formation due to protein-losing enteropathy. (1782939)	MA1ller C.... Knoflach P.	1991	ALB
43	A case of tuberculous pericarditis--use of adenosine deaminase activity (ADA) in early diagnosis. (2228912)	Isaka N.... Nakano T.	1990	ADA

Genes related to pericarditis according to GeneCards:

(show all 35)

id	Symbol	Description	Score	GeneCards Section Context
1	PRG4	proteoglycan 4	11.1	Publications, Aliases & Descriptions, Summaries
2	ADA	adenosine deaminase	11.0	Publications
3	NPPB	natriuretic peptide B	11.0	Publications
4	PRAC	prostate cancer susceptibility candidate	11.0
5	BATF2	basic leucine zipper transcription factor, ATF-like 2	11.0
6	SAR1B	SAR1 homolog B (S. cerevisiae)	11.0
7	TP53I3	tumor protein p53 inducible protein 3	11.0
8	SSX2IP	synovial sarcoma, X breakpoint 2 interacting protein	11.0
9	OLFM1	olfactomedin 1	11.0
10	MEFV	Mediterranean fever	11.0	Publications
11	PSG2	pregnancy specific beta-1-glycoprotein 2	11.0	Publications
12	VTN	vitronectin	11.0	Publications
13	REN	renin	11.0	Publications
14	IGHE	immunoglobulin heavy constant epsilon	11.0
15	ALB	albumin	11.0	Publications
16	SLC22A12	solute carrier family 22 (organic anion/urate transporter), member 12	11.0
17	HRH4	histamine receptor H4	11.0	Publications
18	TPT1	tumor protein, translationally-controlled 1	11.0	Publications
19	TNNI3	troponin I type 3 (cardiac)	11.0
20	IRAK4	interleukin-1 receptor-associated kinase 4	11.0	Publications
21	ACOT12	acyl-CoA thioesterase 12	11.0
22	CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	11.0	Publications
23	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	11.0	Publications
24	DNM1	dynamin 1	11.0
25	G6PD	glucose-6-phosphate dehydrogenase	11.0	Publications
26	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.0
27	IFNA2	interferon, alpha 2	11.0	Publications
28	HSPG2	heparan sulfate proteoglycan 2	11.0	Publications
29	SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	11.0	Publications
30	CRP	C-reactive protein, pentraxin-related	11.0	Publications
31	IL1B	interleukin 1, beta	11.0	Publications
32	IL2	interleukin 2	11.0	Publications
33	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
34	IL8	interleukin 8	11.0	Publications
35	TNF	tumor necrosis factor	11.0	Publications

Pathways related to pericarditis according to GeneDecks:

(show top 50)    (show all 53)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways41	10.7	IRAK4
2	Graft-versus-host disease20	10.3	IL2
3	RAR-Gamma-RXR-Alpha Degradation36	10.3	IL2
4	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.0	IL2, TNFRSF1A
5	14-3-3 Induced Apoptosis36	9.8	IRAK4, IL1B, TNFRSF1A
6	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.5	TNFRSF1A, TNF, IL2
7	Molecular Mechanisms of Cancer36	9.4	PRG4, HRH4, IL6, IL2
8	TRAF Pathway36	9.3	TNFRSF1A, TNF, IL1B, IRAK4
9	Apoptosis20	9.2	TNFRSF1A, TNF, IL1B, IRAK4
10	NF-kappaB Signaling3	9.2	IRAK4, IL1B, TNF, TNFRSF1A
11	African trypanosomiasis20	8.9	IL1B, IL6, TNF
12	PGC1Alpha Pathway36	8.8	TNFRSF1A, IL8, IL2, IL1B
13	Immune response_Bacterial infections in normal airways41	8.7	IL8, IL6, IL1B, IRAK4
14	Tec Kinases Signaling36	8.7	IL2, IL6, IL8, HRH4
15	Measles20	8.7	IFNA2, IL6, IL2, IL1B, IRAK4
16	Akt Signaling36	8.7	TNFRSF1A, TNF, HRH4, IL6, IL2
17	IL-10 Pathway36	8.6	IL1B, IL6, TNF
18	Rho Family GTPases36	8.5	PRG4, HSPG2, IL8, IL2, IL1B
19	Tuberculosis20	8.5	TNFRSF1A, TNF, IFNA2, IL6, IL1B, IRAK4
20	Malaria20	8.4	TNF, IL8, IL6, IL1B
21	Immune response_MIF-mediated glucocorticoid regulation41	8.4	TNF, IL8, IL6, IL2
22	Immune response MIF-mediated glucocorticoid regulation10	8.4	TNF, IL8, IL6, IL2
23	NOD-like receptor signaling pathway20	8.3	TNF, IL8, IL6, IL1B, MEFV
24	Immune response_MIF in innate immunity response41	8.3	TNF, IL8, IL6, IL1B, IRAK4
25	NF-KappaB (p50-p65) Pathway36	8.3	TNFRSF1A, TNF, IL6, IL2, IL1B, IRAK4
26	Immune response MIF in innate immunity response10	8.3	TNF, IL8, IL6, IL1B, IRAK4
27	NF-KappaB Family Pathway36	8.3	TNFRSF1A, TNF, IL6, IL2, IL1B, IRAK4
28	Immune response IL-1 signaling pathway10	8.3	TNF, IL8, IL6, IL1B, IRAK4
29	Immune response_IL-1 signaling pathway41	8.3	IRAK4, IL1B, IL6, IL8, TNF
30	Pertussis20	8.3	TNF, IL8, IL6, IL1B, IRAK4
31	Rheumatoid arthritis20	8.2	IL1B, IL6, IL8, TNF
32	Amoebiasis20	8.0	TNF, IL8, IL6, IL1B
33	Toll-like receptor signaling pathway20	8.0	TNF, IFNA2, IL8, IL6, IL1B, IRAK4
34	Glucocorticoid Receptor Signaling36	7.9	TNFRSF1A, IL8, IL6, IL2, IL1B
35	MIF Mediated Glucocorticoid Regulation36	7.9	TNF, IL8, IL6, IL2, IL1B
36	MIF Regulation of Innate Immune Cells36	7.9	TNF, IL8, IL6, IL2, IL1B
37	all-trans-Retinoic Acid Signaling in Brain36	7.9	IL1B, IL2, IL6, IL8, TNF
38	PEDF Induced Signaling36	7.9	TNF, IL8, IL6, IL2, IL1B
39	MAPK Signaling36	7.8	PRG4, TNFRSF1A, TNF, HSPG2, IL6, IL2
40	IL-6 Pathway36	7.8	IL1B, IL2, IL6, IL8, TNF
41	Influenza A20	7.7	TNFRSF1A, TNF, IFNA2, IL8, IL6, IL1B
42	Cytokine Network36	7.7	IL1B, IL2, IL6, IL8, IFNA2, TNF
43	JAK-STAT Pathway36	7.5	TNFRSF1A, IFNA2, IL8, IL6, IL2, IL1B
44	STAT3 Pathway36	7.5	TNFRSF1A, TNF, HRH4, IL8, IL6, IL2
45	Chagas disease (American trypanosomiasis)20	7.5	TNFRSF1A, TNF, IL8, IL6, IL2, IL1B
46	MAPK Family Pathway36	7.5	TNFRSF1A, TNF, IL8, IL6, IL2, IL1B
47	Antioxidant Action of Vitamin-C36	7.4	TNFRSF1A, TNF, HRH4, IL8, IL6, IL2
48	Cytokine-cytokine receptor interaction20	7.4	TNFRSF1A, TNF, IFNA2, IL8, IL6, IL2
49	p38 Signaling36	7.3	TNFRSF1A, TNF, HRH4, IL8, IL6, IL2
50	ERK Signaling36	7.1	PRG4, TNF, HSPG2, IL8, IL6, IL2

Compounds related to pericarditis according to GeneDecks:

(show top 50)    (show all 205)

id	Compound	Score	Top Affiliating Genes
1	gamma globulin32	10.5	ALB
2	n acetylcysteine32	10.3	SLC17A5, IGHE
3	pioglitazone32 9 9	12.3	NPPB, SLC17A5
4	ivig32	10.2	CRP, PIK3C2A
5	polyethylene glycol32	10.1	VTN, G6PD, IFNA2
6	hyaluronic acid32 18	11.1	PRG4, SLC17A5, VTN
7	pge232	10.1	NPPB, HSPG2, VTN, REN
8	heparin32 9 18 9	12.8	PIK3C2A, HSPG2, VTN, ALB
9	aspartate32	9.8	SLC17A5, PIK3C2A, VTN, CEACAM3
10	fosinopril32 9 9	11.7	CRP, REN, ALB, NPPB
11	endotoxin32	9.7	TNFRSF1A, CRP, SLC17A5, MEFV
12	epinephrine32 9 18 9	12.5	SLC17A5, NPPB, ADA, PIK3C2A, IGHE, VTN
13	losartan32 34 9 9	12.3	ALB, HSPG2, CRP, SLC22A12, REN, NPPB
14	ascorbic acid32 18	10.2	IGHE, G6PD, SLC17A5, HSPG2, IFNA2
15	uric acid32 18	10.0	ALB, SLC22A12, CRP, PIK3C2A, G6PD, NPPB
16	tenidap42 32	9.9	TNF, IL6, IL1B
17	bucillamine32	8.8	CRP, IL6, IL1B, IL2
18	thyroxine32 18	9.7	ALB, IFNA2, SLC17A5, IGHE, CEACAM3, NPPB
19	anakinra32 9 9	10.6	TNF, CRP, IL6, IL1B
20	creatinine32	8.6	REN, CEACAM3, IGHE, TNFRSF1A, TNNI3, CRP
21	okt332	8.4	IL6, CRP, IL2, TNF, TNFRSF1A
22	2,5-oligoadenylate32	8.4	IFNA2, TNF, ADA, IL6, IL2
23	vegf32	8.3	CRP, TNFRSF1A, HSPG2, IL1B, CEACAM3, REN
24	norepinephrine32 9 18 9	11.3	ADA, REN, NPPB, SLC17A5, IL6, IGHE
25	prostacyclin32	8.2	TNFRSF1A, HSPG2, PIK3C2A, REN, VTN, IL1B
26	infliximab32 9 9	10.1	IGHE, IL1B, IL6, TNFRSF1A, TNF, CRP
27	thalidomide32 42 9 9	11.0	VTN, TNFRSF1A, TNF, IFNA2, IL6, IL2
28	8-isoprostane32	8.0	IL6, IL8, TNF, CRP, NPPB
29	taurine chloramine32	7.9	IL2, TNF, IL8, IL1B, IL6
30	il-1232	7.9	IL2, IL1B, IL8, TNF, IL6
31	gm-csf32	7.8	IL8, TNF, IL6, IL2, IL1B
32	gabexate mesilate32	7.8	CRP, IL6, TNF, IL8
33	pentoxifylline32 9 9	9.8	NPPB, TNF, IL8, IL6, IL2, IL1B
34	triptolide32	7.7	IL8, IL1B, IL2, TNF, IL6
35	fmlp32	7.7	ADA, IL8, IL1B, TPT1, TNFRSF1A, TNF
36	hydrocortisone32 9 9	9.5	IL1B, IL2, REN, IL8, IGHE, TNF
37	etanercept32 9 9	9.5	IFNA2, TNFRSF1A, IL6, TNF, IL1B, IL8
38	prednisolone32 9 9	9.4	CRP, SLC17A5, NPPB, TNF, ALB, PIK3C2A
39	alanine32	7.3	VTN, HSPG2, IFNA2, IGHE, IL6, CEACAM3
40	methotrexate32 34 42 9 9	11.3	ADA, IGHE, IL6, TNFRSF1A, CRP, TNF
41	simvastatin32 34 42 9 18 9	12.2	TNFRSF1A, PIK3C2A, IL6, HSPG2, IL8, TNF
42	herbimycin a32 42	8.2	HSPG2, IL2, IL8, TNFRSF1A, IL6, TNF
43	indomethacin32 9 9	9.1	REN, ADA, IL2, IL1B, TNF, IGHE
44	cyclosporin a32 42	8.0	SLC17A5, PIK3C2A, NPPB, ADA, TNF, IGHE
45	actinomycin d32	7.0	TNFRSF1A, TNF, NPPB, IGHE, IL8, G6PD
46	dexamethasone32 42 34 9 9	10.6	REN, IL1B, IL2, IL6, VTN, IGHE
47	neopterin32	6.5	ADA, IL8, IL6, IL2, IL1B, IFNA2
48	cycloheximide32	6.4	IL8, IL6, IL2, IL1B, HSPG2, TNFRSF1A
49	histamine32 18	7.3	IL8, ADA, NPPB, TNF, IL1B, IL2
50	lactate32	6.0	VTN, G6PD, PSG2, NPPB, CEACAM3, IL6

Cellular components related to pericarditis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	6.0	PRG4, PSG2, CRP, TNFRSF1A, HSPG2, ALB
2	extracellular space	GO:005615	4.8	REN, ADA, NPPB, CRP, OLFM1, TNFRSF1A

Biological processes related to pericarditis according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.6	TNF, IL1B
2	negative regulation of inflammatory response	GO:050728	9.6	ADA, TNFRSF1A, IL2, MEFV
3	sequestering of triglyceride	GO:030730	9.6	TNF, IL1B
4	chronic inflammatory response to antigenic stimulus	GO:002439	9.6	TNF, IL1B
5	positive regulation of heterotypic cell-cell adhesion	GO:034116	9.5	IL1B, TNF
6	embryonic digestive tract development	GO:048566	9.2	IL8, TNF, ADA
7	negative regulation of lipid storage	GO:010888	9.2	CRP, TNF, IL6
8	positive regulation of interferon-gamma production	GO:032729	9.0	TNF, IL2, IL1B
9	response to hypoxia	GO:001666	8.8	IL1B, TNF, TNFRSF1A, CRP, NPPB, ADA
10	positive regulation of interleukin-6 production	GO:032755	8.6	IL1B, IL6, TNF
11	cytokine-mediated signaling pathway	GO:019221	8.5	TNFRSF1A, IFNA2, IL6, IL1B, IRAK4
12	inflammatory response	GO:006954	6.9	MEFV, NPPB, CRP, TNFRSF1A, TNF, HRH4

Molecular functions related to pericarditis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:005125	8.0	IL1B, IL2, IL6, IFNA2, TNF