MCID: PRC013
MIFTS: 57

Pericarditis malady

Cardiovascular diseases category

Summaries for Pericarditis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Pericarditis is an inflammation of the pericardium (the fibrous sac surrounding the heart). A... more...

MalaCards: Pericarditis is related to constrictive pericarditis and pericardial effusion, and has symptoms including chest pain An important gene associated with Pericarditis is PRG4 (proteoglycan 4), and among its related pathways are Regulation by c-FLIP and NF-kappaB Signaling. The compounds isoproterenol and indomethacin have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and lung, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A heart disease that is characterized by an inflammation of the pericardium and has symptom chest pain.

Aliases & Classifications for Pericarditis

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8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Characteristics (Orphanet epidemiological data):

48
pericarditis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

pericarditis 8 10 44 48 60


External Ids:

Disease Ontology8 DOID:1787
MeSH34 D010493
NCIt39 C34915
SNOMED-CT via Orphanet57 23627006, 3238004
SNOMED-CT56 3238004
UMLS via Orphanet61 C0031046, C0265143
MESH via Orphanet35 D010493
ICD10 via Orphanet26 I30.0, I30.1, I30.8 I30.9, I01.0, more
ICD1025 I32, I32.8

Related Diseases for Pericarditis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pericarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 329)
idRelated DiseaseScoreTop Affiliating Genes
1constrictive pericarditis31.7ADA, NPPB
2pericardial effusion30.8ADA, PSG2
3arthritis30.6TNFRSF1A, TNF, MEFV, VTN, ALB
4myocardial infarction30.5REN, NPPB, TNNI3
5pneumonia30.5VTN, TNF, PSG2
6myocarditis30.5TNNI3, NPPB
7tuberculosis30.4ADA, ALB, TNF, TNFRSF1A
8rheumatoid arthritis30.4ADA, VTN, MEFV, TNF, TNFRSF1A, PRG4
9meningitis30.4IRAK4, ALB, ADA
10arthropathy30.4PRG4, TNF
11protein-losing enteropathy30.3ALB
12acute myocardial infarction30.3MEFV, NPPB, TNNI3
13systemic lupus erythematosus30.3VTN, ADA, TNFRSF1A, TNF
14influenza30.1ADA
15amyloidosis30.1ALB, MEFV, NPPB, TNFRSF1A
16leukemia30.1TNFRSF1A, TNF, PSG2, ADA
17vasculitis30.1TNF, ALB, MEFV
18pancreatitis30.0ALB
19hepatitis c30.0ALB
20sarcoma29.8ADA
21crohn's disease29.8ALB, TNF
22sarcoidosis29.8ADA, TNF, VTN
23familial mediterranean fever29.8MEFV, TNF, TNFRSF1A
24asthma29.8TNF, HRH4, VTN, IGHE
25kawasaki disease29.6NPPB
26leishmaniasis29.6TNFRSF1A
27cystic fibrosis29.6ALB
28brucellosis29.6MEFV
29dermatomyositis29.6VTN
30hypertrophic cardiomyopathy29.6TNNI3
31nephrotic syndrome29.6VTN, ALB
32pancreatic cancer29.6PSG2, VTN
33glomerulonephritis29.6ALB, VTN
34uveitis29.6TNF, TNFRSF1A
35congestive heart failure29.6REN, TNNI3
36dilated cardiomyopathy29.6TNNI3, NPPB
37adenocarcinoma29.6ADA, VTN, PSG2
38psoriasis29.6VTN, TNF, TNFRSF1A
39behcet's disease29.6TNF, ADA, MEFV
40liver cirrhosis29.6ALB, ADA, REN
41peritonitis29.6ADA, ALB, MEFV, TNF
42myeloma29.6ALB, TNFRSF1A, IGHE, PSG2
43blau syndrome29.6TNF, MEFV
44chronic kidney failure29.6REN, TNNI3, ALB, ADA, VTN, NPPB
45diabetes mellitus29.6NPPB, ALB, TNFRSF1A, TNF, REN, VTN
46restrictive cardiomyopathy10.6
47cardiac tamponade10.6
48camptodactyly arthropathy coxa vara pericarditis syndrome10.4
49hemopericardium10.4
50endocarditis10.3

Graphical network of the top 20 diseases related to Pericarditis:



Diseases related to pericarditis

Clinical Features for Pericarditis

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Sources:
8Disease Ontology
See all sources


Symptoms:

8
  • chest pain

Drugs & Therapeutics for Pericarditis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pericarditis

Drug clinical trials:

Search ClinicalTrials for Pericarditis

Search NIH Clinical Center for Pericarditis

Search CenterWatch for Pericarditis

Genetic Tests for Pericarditis

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Anatomical Context for Pericarditis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Pericarditis:

32
Heart, Liver, Lung, Bone, Testes, Bone marrow, Brain, Thyroid, Breast, Kidney, T cells, Myeloid, B cells, Lymph node

Animal Models for Pericarditis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Pericarditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053879.2TNF, IRAK4, MEFV, IGHE, BATF2, REN
2MP:00053979.1TNFRSF1A, TNF, IRAK4, MEFV, IGHE, REN
3MP:00053768.8ADA, SAR1B, TNFRSF1A, TNF, IRAK4, MEFV
4MP:00107688.7SAR1B, TNFRSF1A, TNF, TNNI3, MEFV, PRG4

Publications for Pericarditis

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Sources:
50PubMed
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Articles related to Pericarditis:

(show top 50)    (show all 1007)
idTitleAuthorsYear
1
Constrictive pericarditis developed after childhood repair of ventricular septal defect. (23910801)
2013
2
New development of cardiac tamponade on underlying effusive-constrictive pericarditis: an uncommon initial presentation of scleroderma. (23853085)
2013
3
I Brazilian guidelines on myocarditis and pericarditis. (23765413)
2013
4
Tuberculous pericarditis with and without HIV. (22427006)
2013
5
Child-Pugh score predicts survival after radical pericardiectomy for constrictive pericarditis. (23998414)
2013
6
Clues to detect tumor necrosis factor receptor-associated periodic syndrome (TRAPS) among patients with idiopathic recurrent acute pericarditis: results of a multicentre study. (22311714)
2012
7
Angina as a manifestation of constrictive pericarditis. (22821119)
2012
8
First report of infectious pericarditis due to Bordetella holmesii in an adult patient with malignant lymphoma. (22378902)
2012
9
Pericardial involvement in diseases of the heart and other contiguous structures: part I: pericardial involvement in infarct pericarditis and pericardial involvement following myocardial infarction. (22472431)
2012
10
Recurrent pericarditis: autoimmune or autoinflammatory? (22884556)
2012
11
Primary malignant pericardial mesothelioma presenting as acute pericarditis. (22509441)
2012
12
Uremic pericarditis. (21598820)
2011
13
Effusive-constrictive pericarditis post surgical revision for iatrogenic hemopericardium. (21475381)
2011
14
A girl with right heart failure related to effusive-constrictive pericarditis. (21359949)
2011
15
Extensive infectious panel testing for acute pericarditis: a ghost hunt? (21934304)
2011
16
Localized constrictive pericarditis causing apical pseudo-ballooning. (22117914)
2011
17
Effusive-constrictive pericarditis: the role of noninvasive imaging. (21815524)
2011
18
Recurrent pericarditis: an autoimmune disease? (20448122)
2010
19
Cardiac tamponade mimicking tuberculous pericarditis as the initial presentation of chronic lymphocytic leukemia in a 58-year-old woman: a case report. (20684780)
2010
20
Sacroileitis and pericarditis: atypical presentation of tumor necrosis factor receptor-associated periodic syndrome and response to etanercept therapy. (20483057)
2010
21
Images in cardiovascular medicine. Fading out dip-and-plateau pattern of right ventricular pressure in constrictive pericarditis. (20660816)
2010
22
Cardiogenic shock following cesarean delivery due to undiagnosed tuberculous constrictive pericarditis. (20708920)
2010
23
Morganella morganii pericarditis in a child with X-linked agammaglobulinemia. (20723125)
2010
24
Pericarditis and chronic inflammatory demyelinating polyneuropathy during therapy with pegylated interferon alfa-2a for chronic hepatitis C. (21161021)
2010
25
Keypoints in surgery of constrictive pericarditis]. (19780238)
2009
26
Recurrent pericarditis in hyper-IgD syndrome. (19772809)
2009
27
Fatal acute purulent pericarditis in a patient with renal transplant: a case report. (19364316)
2009
28
Churg-Strauss syndrome revealed by granulomatous acute pericarditis: two case reports and a review of the literature. (17303217)
2007
29
Protein-losing enteropathy as the principal manifestation of constrictive pericarditis. (16191147)
2005
30
Constrictive pericarditis associated with right atrial and major venous thrombosis. (15368807)
2004
31
Subacute effusive-constrictive pericarditis: diagnosis by serial echocardiography. (15502799)
2004
32
Effusive-constrictive pericarditis. (14749455)
2004
33
Chronic constrictive pericarditis: pending issues. (14686660)
2003
34
Chylothorax as the first manifestation of constrictive pericarditis. (12829211)
2003
35
The hemodynamic signs of constrictive pericarditis can be mimicked by tricuspid regurgitation. (14580301)
2003
36
Angina caused by calcific constrictive pericarditis. (12484734)
2002
37
Atlantoaxial subluxation and pericarditis in a child with Crohn's disease. (11721771)
2001
38
Hearts of stone: calcific constrictive pericarditis. (10892404)
2000
39
Images in clinical medicine. Constrictive pericarditis. (10891519)
2000
40
A case of constrictive pericarditis with local thickening of the pericardium without manifest ventricular interdependence. (10754354)
1999
41
Pericarditis and Mediterranean spotted fever. (9505185)
1998
42
Characteristics of coronary flow velocity in constrictive pericarditis. (9600526)
1998
43
Pericardiectomy after two decades of constrictive pericarditis in a patient with chronic renal failure. (8592610)
1995
44
Doppler echocardiography in constrictive pericarditis. (8077565)
1994
45
Constrictive pericarditis simulating intestinal lymphangiectasia in a patient with the Noonan syndrome. (8335455)
1993
46
Recurrent pericarditis and dermatitis herpetiformis. Evidence for immune complex deposition in the pericardium. (2323232)
1990
47
Constrictive pericarditis and protein losing enteropathy. An imitator of intestinal lymphangiectasis. (1155672)
1975
48
Purulent pericarditis complicating meningococcal meningitis. Report of a child with cardiac tamponade and survival. (6019458)
1967
49
LEFT-SIDED AMOEBIC LIVER ABSCESS WITH PULMONARY INVOLVEMENT, PERICARDITIS, AND PSEUDOCHOLINESTERASE DEFICIENCY. (14228159)
1965
50
Constrictive pericarditis following traumatic hemopericardium. (14388616)
1955

Genetic Variations for Pericarditis

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Expression for genes affiliated with Pericarditis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pericarditis

Search GEO for disease gene expression data for Pericarditis.

Pathways for genes affiliated with Pericarditis

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53Reactome, 4Cell Signaling Technology, 29KEGG
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Pathways related to Pericarditis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2TNF, TNFRSF1A
210.1IRAK4, TNF, TNFRSF1A
310.1IRAK4, TNF, TNFRSF1A

Compounds for genes affiliated with Pericarditis

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Pericarditis according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1isoproterenol44 1111.7ADA
2indomethacin44 59 28 1113.7REN, NPPB
3ornipressin4410.6REN, ALB
4alacepril4410.6NPPB, REN
5prednisolone44 28 1112.6NPPB, IGHE
6norepinephrine44 11 2412.5TNFRSF1A, IGHE
7fosinopril44 1111.5ALB, REN, NPPB
8lisinopril44 11 2412.5REN, NPPB, ALB
9darusentan44 2811.5NPPB, REN
10ramipril44 1111.5NPPB, ALB, REN
1151-cr-edta4410.5REN, ALB
12valsartan44 59 28 1113.5REN, ALB, NPPB
13hhpa4410.5IGHE, ALB
14telmisartan44 28 1112.5REN, NPPB, ALB
15perindopril44 49 1112.5NPPB, REN, ALB
16candesartan44 28 1112.5REN, NPPB, ALB
17enalapril44 49 1112.5REN, NPPB, ALB
18amlodipine44 49 11 2413.5NPPB, REN, ALB
19spironolactone49 44 59 28 1114.5ALB, REN, NPPB
20furosemide44 49 59 28 11 2415.4NPPB, REN, ALB
21indapamide44 1111.4REN, ALB
22captopril44 28 49 59 1114.4NPPB, REN, ALB
23terlipressin44 1111.4REN, ALB
24polyethylene glycol4410.4ADA, TNFRSF1A, VTN, ALB
25losartan44 49 28 1113.4ALB, REN, SLC22A12, NPPB
26urodilatin4410.3NPPB, REN
27latex4410.3PSG2, IGHE, VTN, PRG4
28ivig4410.3IGHE, TNFRSF1A, TNF, ALB
29infliximab44 49 1112.3TNFRSF1A, TNF, IGHE
30heparin44 28 11 2413.3TNFRSF1A, VTN
31l-nmma4410.3TNF, IGHE, NPPB
32prostacyclin4410.3NPPB, TNFRSF1A, TNF, REN, VTN
33tacrolimus44 49 1112.3ALB, VTN, TNF, REN, NPPB
34thyroxine44 2411.3ALB, REN, IGHE, NPPB
35kininogen4410.3VTN, ALB, REN
36bisoprolol44 49 1112.2REN, NPPB
37epinephrine44 11 2412.2VTN, NPPB, IGHE, REN, ADA
38methotrexate44 49 1112.2TNFRSF1A, ADA, IGHE, TNF, ALB
39calcitriol44 59 11 2413.2TNFRSF1A, TNF, REN, ALB
40trandolapril44 1111.1REN, NPPB
41pge24410.1TNF, VTN, REN, NPPB, TNFRSF1A
42cyclosporin a44 28 5912.1TNF, ADA, IGHE, TNFRSF1A, NPPB
43neopterin4410.1TNF, TNFRSF1A, ADA
44histamine44 28 2412.1HRH4, NPPB, TNF, ADA, ALB, IGHE
45aspartate4410.1VTN, ALB, ADA, IGHE
46dexamethasone44 49 28 1113.0IGHE, NPPB, ADA, VTN, TNFRSF1A, TNF
47hanp449.9NPPB, REN
48vegf449.9NPPB, PSG2, IGHE, ADA, REN, TNFRSF1A
49lactate449.8IGHE, TNNI3, PSG2, VTN, ALB, ADA
50creatinine449.7ALB, PSG2, IGHE, TNNI3, SLC22A12, TNFRSF1A

GO Terms for genes affiliated with Pericarditis

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Sources:
16Gene Ontology
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Cellular components related to Pericarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.4TNF, NPPB, PSG2, IGHE, REN, VTN
2extracellular spaceGO:0056159.2ADA, TNFRSF1A, TNF, NPPB, PRG4, REN

Biological processes related to Pericarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of inflammatory responseGO:05072810.0ADA, MEFV, TNFRSF1A
2inflammatory responseGO:00695410.0HRH4, MEFV, TNF, TNFRSF1A
3regulation of MAPK cascadeGO:0434089.9HRH4, REN

Molecular functions related to Pericarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1polysaccharide bindingGO:03024710.2VTN, PRG4

Products for genes affiliated with Pericarditis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pericarditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet