MCID: PRN019
MIFTS: 31

Perinatal Necrotizing Enterocolitis malady

Rare diseases, Fetal diseases, Gastrointestinal diseases, Neuronal diseases, Cancer diseases categories

Aliases & Classifications for Perinatal Necrotizing Enterocolitis

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Sources:
9Disease Ontology, 11DISEASES, 41NIH Rare Diseases, 47Orphanet, 43Novoseek, 60UMLS, 55SNOMED-CT, 38NCIt, 33MeSH, 26ICD10 via Orphanet, 25ICD10
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Perinatal Necrotizing Enterocolitis, Aliases & Descriptions:

Name: Perinatal Necrotizing Enterocolitis 9 11
Necrotizing Enterocolitis 9 41 47
Enterocolitis, Necrotizing 41 60
Enterocolitis Necrotizing 9 43
Necrotizing Enterocolitis in Fetus or Newborn 9
 
Pseudomembranous Enterocolitis in Newborn 9
Perinatal Necrotising Enterocolitis 9
Carcinoma, Neuroendocrine 60
Nec 41


Classifications:



External Ids:

Disease Ontology9 DOID:8677
NCIt38 C84915
MeSH33 D020345
Orphanet47 391673
ICD10 via Orphanet26 P77
ICD1025 P77

Summaries for Perinatal Necrotizing Enterocolitis

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NIH Rare Diseases:41 Necrotizing enterocolitis (nec) is a condition characterized by variable injury or damage to the intestinal tract, causing death of intestinal tissue. the condition most often occurs in premature newborns, but it may also occur in term or near-term babies. signs and symptoms may include abdominal distension, bloody stools, vomiting bile-stained fluid, and pneumatosis intestinalis (gas in the bowel wall) identified on abdominal x-ray. affected infants occasionally have temperature instability, lethargy, or other findings of sepsis. the exact cause of nec is unknown. treatment involves stopping feedings, passing a small tube into the stomach to relieve gas, and giving intravenous fluids and antibiotics. surgery may be needed if there is perforated or necrotic (dead) bowel tissue. about 60-80% of affected newborns survive the condition. last updated: 2/4/2013

MalaCards based summary: Perinatal Necrotizing Enterocolitis, also known as necrotizing enterocolitis, is related to chorioamnionitis and inflammatory bowel disease. An important gene associated with Perinatal Necrotizing Enterocolitis is HBEGF (heparin-binding EGF-like growth factor), and among its related pathways are Proteoglycans in cancer and Development Slit Robo signaling. The compounds tgf beta1 and chlorate have been mentioned in the context of this disorder. Related mouse phenotypes are skeleton and respiratory system.

Related Diseases for Perinatal Necrotizing Enterocolitis

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Graphical network of the top 20 diseases related to Perinatal Necrotizing Enterocolitis:



Diseases related to perinatal necrotizing enterocolitis

Symptoms for Perinatal Necrotizing Enterocolitis

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Drugs & Therapeutics for Perinatal Necrotizing Enterocolitis

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Drug clinical trials:

Search ClinicalTrials for Perinatal Necrotizing Enterocolitis

Search NIH Clinical Center for Perinatal Necrotizing Enterocolitis

Genetic Tests for Perinatal Necrotizing Enterocolitis

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Anatomical Context for Perinatal Necrotizing Enterocolitis

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Animal Models for Perinatal Necrotizing Enterocolitis or affiliated genes

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MGI Mouse Phenotypes related to Perinatal Necrotizing Enterocolitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.8SERPINH1, HBEGF, TLR4
2MP:00053888.5SERPINH1, HBEGF, TLR4

Publications for Perinatal Necrotizing Enterocolitis

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Variations for Perinatal Necrotizing Enterocolitis

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Expression for genes affiliated with Perinatal Necrotizing Enterocolitis

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Search GEO for disease gene expression data for Perinatal Necrotizing Enterocolitis.

Pathways for genes affiliated with Perinatal Necrotizing Enterocolitis

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Pathways related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4HBEGF, TLR4
2
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion58
Pathogenic Escherichia coli infection36
Cytoskeleton remodeling Slit Robo signaling
9.4HBEGF, TLR4

Compounds for genes affiliated with Perinatal Necrotizing Enterocolitis

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Compounds related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

(show all 37)
idCompoundScoreTop Affiliating Genes
1tgf beta1439.7HBEGF, TLR4
2chlorate439.5LTF, HBEGF
3pneumococcal439.5LTF, TLR4
4zymosan439.5TLR4, LTF
5polymyxin b439.5TLR4, LTF
6anti-fungal439.5LTF, TLR4
7c2ceramide439.5LTF, TLR4
8chondroitin sulfate43 2410.5HBEGF, LTF
9sb 20358043 5910.4HBEGF, TLR4
10carbohydrates439.4LTF, TLR4
11mannose439.4TLR4, LTF
12heparan sulfate43 2410.4LTF, HBEGF
13endotoxin439.4LTF, TLR4
14fmlp439.3TLR4, LTF
15nacl439.3LTF, HBEGF
16vitamin a43 24 1211.3LTF, HBEGF
17nitric oxide43 24 1211.1SERPINH1, HBEGF, TLR4
18polyacrylamide439.1SERPINH1, LTF
19phospholipid439.1HBEGF, TLR4
20histamine43 28 2411.1LTF, TLR4
21atp43 2810.1SERPINH1, HBEGF, TLR4
22ascorbic acid43 2410.1LTF, SERPINH1
23latex439.0LTF, HBEGF, TLR4
24n acetylcysteine439.0TLR4, HBEGF, LTF
25polysaccharide439.0LTF, HBEGF, TLR4
26fibrinogen439.0LTF, HBEGF, TLR4
27actinomycin d439.0LTF, HBEGF, TLR4
28pge2439.0LTF, HBEGF, TLR4
29h2o2439.0TLR4, HBEGF, LTF
30dexamethasone43 49 28 1212.0TLR4, HBEGF, LTF
31alanine438.9LTF, HBEGF, TLR4
32retinoic acid43 249.9TLR4, HBEGF, LTF
33cysteine438.9TLR4, HBEGF, LTF
34cyclosporin a43 28 5910.9LTF, SERPINH1, TLR4
35tyrosine438.7TLR4, HBEGF, SERPINH1
36vegf438.4TLR4, HBEGF, SERPINH1, LTF
37serine438.4TLR4, HBEGF, SERPINH1, LTF

GO Terms for genes affiliated with Perinatal Necrotizing Enterocolitis

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Cellular components related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.5LTF, SERPINH1, HBEGF

Biological processes related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.1LTF, TLR4
2positive regulation of NF-kappaB transcription factor activityGO:00510928.8LTF, TLR4

Molecular functions related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00082019.1LTF, HBEGF

Products for genes affiliated with Perinatal Necrotizing Enterocolitis

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Sources for Perinatal Necrotizing Enterocolitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet