NEC
MCID: PRN019
MIFTS: 35

Perinatal Necrotizing Enterocolitis (NEC) malady

Rare diseases, Fetal diseases, Gastrointestinal diseases categories

Summaries for Perinatal Necrotizing Enterocolitis

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44NIH Rare Diseases, 34MalaCards
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NIH Rare Diseases:44 Necrotizing enterocolitis (nec) is a condition characterized by variable injury or damage to the intestinal tract, causing death of intestinal tissue. the condition most often occurs in premature newborns, but it may also occur in term or near-term babies. signs and symptoms may include abdominal distension, bloody stools, vomiting bile-stained fluid, and pneumatosis intestinalis (gas in the bowel wall) identified on abdominal x-ray. affected infants occasionally have temperature instability, lethargy, or other findings of sepsis. the exact cause of nec is unknown. treatment involves stopping feedings, passing a small tube into the stomach to relieve gas, and giving intravenous fluids and antibiotics. surgery may be needed if there is perforated or necrotic (dead) bowel tissue. about 60-80% of affected newborns survive the condition. last updated: 2/4/2013

MalaCards: Perinatal Necrotizing Enterocolitis, also known as necrotizing enterocolitis, is related to sepsis and inflammatory bowel disease. An important gene associated with Perinatal Necrotizing Enterocolitis is HBEGF (heparin-binding EGF-like growth factor), and among its related pathways are Proteoglycans in cancer and Development Slit Robo signaling. The compounds tgf beta1 and chlorate have been mentioned in the context of this disorder. Related mouse phenotypes are skeleton and respiratory system.

Aliases & Classifications for Perinatal Necrotizing Enterocolitis

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9Disease Ontology, 11DISEASES, 46Novoseek, 44NIH Rare Diseases, 50Orphanet, 63UMLS, 36MeSH, 41NCIt, 59SNOMED-CT, 27ICD10 via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Fetal diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

perinatal necrotizing enterocolitis 9 11
necrotizing enterocolitis 9 44 50
enterocolitis, necrotizing 44 63
enterocolitis necrotizing 9 46
necrotizing enterocolitis in fetus or newborn 9
pseudomembranous enterocolitis in newborn 9
perinatal necrotising enterocolitis 9
nec 44


External Ids:

Disease Ontology9 DOID:8677
MeSH36 D020345
NCIt41 C84915
ICD10 via Orphanet27 P77
ICD1026 P77

Related Diseases for Perinatal Necrotizing Enterocolitis

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Perinatal Necrotizing Enterocolitis:



Diseases related to perinatal necrotizing enterocolitis

Symptoms for Perinatal Necrotizing Enterocolitis

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Drugs & Therapeutics for Perinatal Necrotizing Enterocolitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Perinatal Necrotizing Enterocolitis

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Genetic Tests for Perinatal Necrotizing Enterocolitis

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Anatomical Context for Perinatal Necrotizing Enterocolitis

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Animal Models for Perinatal Necrotizing Enterocolitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Perinatal Necrotizing Enterocolitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.8SERPINH1, HBEGF, TLR4
2MP:00053888.5SERPINH1, HBEGF, TLR4

Publications for Perinatal Necrotizing Enterocolitis

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Variations for Perinatal Necrotizing Enterocolitis

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Expression for genes affiliated with Perinatal Necrotizing Enterocolitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Perinatal Necrotizing Enterocolitis

Search GEO for disease gene expression data for Perinatal Necrotizing Enterocolitis.

Pathways for genes affiliated with Perinatal Necrotizing Enterocolitis

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Sources:
51PathCards, 31KEGG, 61Thomson Reuters, 39NCBI BioSystems Database, 13EMD Millipore
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Pathways related to Perinatal Necrotizing Enterocolitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4HBEGF, TLR4
2
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion61
Pathogenic Escherichia coli infection39
9.4HBEGF, TLR4

Compounds for genes affiliated with Perinatal Necrotizing Enterocolitis

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Sources:
46Novoseek, 25HMDB, 62Tocris Bioscience, 12DrugBank, 30IUPHAR, 52PharmGKB
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Compounds related to Perinatal Necrotizing Enterocolitis according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1tgf beta1469.7HBEGF, TLR4
2chlorate469.5LTF, HBEGF
3pneumococcal469.5LTF, TLR4
4zymosan469.5TLR4, LTF
5polymyxin b469.5TLR4, LTF
6anti-fungal469.5LTF, TLR4
7c2ceramide469.5LTF, TLR4
8chondroitin sulfate46 2510.5HBEGF, LTF
9sb 20358046 6210.4HBEGF, TLR4
10carbohydrates469.4LTF, TLR4
11mannose469.4TLR4, LTF
12heparan sulfate46 2510.4LTF, HBEGF
13endotoxin469.4LTF, TLR4
14fmlp469.3TLR4, LTF
15nacl469.3LTF, HBEGF
16vitamin a46 25 1211.3LTF, HBEGF
17nitric oxide46 25 1211.1SERPINH1, HBEGF, TLR4
18polyacrylamide469.1SERPINH1, LTF
19phospholipid469.1HBEGF, TLR4
20histamine46 30 2511.1LTF, TLR4
21atp46 3010.1SERPINH1, HBEGF, TLR4
22ascorbic acid46 2510.1LTF, SERPINH1
23latex469.0LTF, HBEGF, TLR4
24n acetylcysteine469.0TLR4, HBEGF, LTF
25polysaccharide469.0LTF, HBEGF, TLR4
26fibrinogen469.0LTF, HBEGF, TLR4
27actinomycin d469.0LTF, HBEGF, TLR4
28pge2469.0LTF, HBEGF, TLR4
29h2o2469.0TLR4, HBEGF, LTF
30dexamethasone46 52 30 1212.0TLR4, HBEGF, LTF
31alanine468.9LTF, HBEGF, TLR4
32retinoic acid46 259.9TLR4, HBEGF, LTF
33cysteine468.9TLR4, HBEGF, LTF
34cyclosporin a46 30 6210.9LTF, SERPINH1, TLR4
35tyrosine468.7TLR4, HBEGF, SERPINH1
36vegf468.4TLR4, HBEGF, SERPINH1, LTF
37serine468.4TLR4, HBEGF, SERPINH1, LTF

GO Terms for genes affiliated with Perinatal Necrotizing Enterocolitis

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17Gene Ontology
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Cellular components related to Perinatal Necrotizing Enterocolitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5LTF, SERPINH1, HBEGF

Biological processes related to Perinatal Necrotizing Enterocolitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.1LTF, TLR4
2positive regulation of NF-kappaB transcription factor activityGO:0510928.8LTF, TLR4

Molecular functions related to Perinatal Necrotizing Enterocolitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082019.1LTF, HBEGF

Products for genes affiliated with Perinatal Necrotizing Enterocolitis

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  • Antibodies
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  • Antibodies

Sources for Perinatal Necrotizing Enterocolitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet