MCID: PRN019
MIFTS: 56

Perinatal Necrotizing Enterocolitis

Categories: Rare diseases, Fetal diseases, Gastrointestinal diseases

Aliases & Classifications for Perinatal Necrotizing Enterocolitis

MalaCards integrated aliases for Perinatal Necrotizing Enterocolitis:

Name: Perinatal Necrotizing Enterocolitis 12 14
Necrotizing Enterocolitis 12 49 55 69
Enterocolitis, Necrotizing 49 41
Enterocolitis Necrotizing 12 51
Necrotizing Enterocolitis in Fetus or Newborn 12
Pseudomembranous Enterocolitis in Newborn 12
Perinatal Necrotising Enterocolitis 12
Nec 49

Characteristics:

Orphanet epidemiological data:

55
necrotizing enterocolitis
Prevalence: 1-5/10000 (Worldwide); Age of onset: Neonatal; Age of death: infantile;

Classifications:



External Ids:

Disease Ontology 12 DOID:8677
MeSH 41 D020345
NCIt 46 C84915
Orphanet 55 ORPHA391673
UMLS via Orphanet 70 C0520459
ICD10 via Orphanet 33 P77
ICD10 32 P77
UMLS 69 C0520459

Summaries for Perinatal Necrotizing Enterocolitis

NIH Rare Diseases : 49 Necrotizing enterocolitis (NEC) is a condition characterized by variable injury or damage to the intestinal tract, causing death of intestinal tissue. The condition most often occurs in premature newborns, but it may also occur in term or near-term babies. Signs and symptoms may include abdominal distension, bloody stools, vomiting bile-stained fluid, and pneumatosis intestinalis (gas in the bowel wall) identified on abdominal x-ray. Affected infants occasionally have temperature instability, lethargy, or other findings of sepsis. The exact cause of NEC is unknown. Treatment involves stopping feedings, passing a small tube into the stomach to relieve gas, and giving intravenous fluids and antibiotics. Surgery may be needed if there is perforated or necrotic (dead) bowel tissue. About 60-80% of affected newborns survive the condition. Last updated: 2/4/2013

MalaCards based summary : Perinatal Necrotizing Enterocolitis, also known as necrotizing enterocolitis, is related to fasciitis and short bowel syndrome. An important gene associated with Perinatal Necrotizing Enterocolitis is FABP2 (Fatty Acid Binding Protein 2), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Indomethacin and Poractant alfa have been mentioned in the context of this disorder. Affiliated tissues include heart, breast and colon, and related phenotypes are digestive/alimentary and immune system

Related Diseases for Perinatal Necrotizing Enterocolitis

Diseases related to Perinatal Necrotizing Enterocolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 251)
# Related Disease Score Top Affiliating Genes
1 fasciitis 29.5 CXCL8 IL6 TNF
2 short bowel syndrome 11.4
3 eye lymphoma 10.4 IL6 TLR9
4 prosthetic joint infection 10.3 IL1B TLR4
5 cervical incompetence 10.3 IL6 SERPINH1
6 spondylarthropathy 10.3 TLR4 TNF
7 pouchitis 10.2 CXCL8 TLR4
8 scorpion envenomation 10.2 IL6 TNF
9 trench fever 10.2 TLR4 TNF
10 acute transverse myelitis 10.2 CXCL8 IL6
11 tympanosclerosis 10.2 TLR4 TNF
12 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL6 TNF
13 critical limb ischemia 10.2 IL6 TNF
14 invasive aspergillosis 10.2 CXCL8 TLR4 TLR9
15 periodontitis, chronic 10.2 IL1B IL6
16 adult dermatomyositis 10.2 TLR9 TNF
17 polyposis, gastric 10.2 IL1B TNF
18 tungiasis 10.2 CXCL8 TNF
19 null-cell leukemia 10.1 IL6 TNF
20 systemic onset juvenile idiopathic arthritis 10.1 IL1B TNF
21 staphylococcal toxic shock syndrome 10.1 IL1B TNF
22 keratitis, hereditary 10.1 IL1B TLR4 TLR9
23 bacteriuria 10.1 CXCL8 IL6 TLR4
24 cutaneous leishmaniasis 10.1 TLR4 TLR9 TNF
25 kashin-beck disease 10.1 IL1B TNF
26 enterocolitis 10.1
27 autoinflammation with infantile enterocolitis 10.1
28 preterm premature rupture of the membranes 10.1 CXCL8 IL6 SERPINH1
29 anterior uveitis 10.1 IL6 TLR4 TNF
30 cysticercosis 10.1 IL1B IL6 TLR4
31 dry eye syndrome 10.1 EGF IL6 TNF
32 human immunodeficiency virus infectious disease 10.1 IL6 TLR9 TNF
33 parasitic protozoa infectious disease 10.0 IL6 TLR9 TNF
34 gastric ulcer 10.0 CXCL8 EGF IL1B
35 paracoccidioidomycosis 10.0 IL6 TLR4 TNF
36 melioidosis 10.0 IL6 TLR4 TNF
37 nose disease 10.0 CXCL8 TLR9 TNF
38 stomach disease 10.0 CXCL8 IL1B TLR9
39 denture stomatitis 10.0 CXCL8 IL6
40 retinitis pigmentosa 55 10.0 IL6 TNF
41 upper respiratory tract disease 10.0 CXCL8 TLR9 TNF
42 vulvar vestibulitis syndrome 10.0 IL1B TNF
43 gastrointestinal system cancer 10.0 IL6 TLR9 TNF
44 keratoconjunctivitis 10.0 CXCL8 TLR9 TNF
45 mycobacterium tuberculosis 1 10.0 TLR4 TLR9 TNF
46 cold agglutinin disease 10.0 CRP IL6
47 myeloma, multiple 10.0 CXCL8 IL6 TLR9
48 interstitial cystitis 10.0 CXCL8 EGF HBEGF IL6
49 recurrent corneal erosion 10.0 CXCL8 IL1B IL6
50 diabetic foot ulcers 10.0 CRP IL6

Graphical network of the top 20 diseases related to Perinatal Necrotizing Enterocolitis:



Diseases related to Perinatal Necrotizing Enterocolitis

Symptoms & Phenotypes for Perinatal Necrotizing Enterocolitis

MGI Mouse Phenotypes related to Perinatal Necrotizing Enterocolitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.5 SIGIRR TLR4 TLR9 TNF EGF IL6
2 immune system MP:0005387 9.32 THPO TLR4 TLR9 TNF CRP EGF

Drugs & Therapeutics for Perinatal Necrotizing Enterocolitis

Drugs for Perinatal Necrotizing Enterocolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 239)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Indomethacin Approved, Investigational Phase 4,Phase 3,Phase 2 53-86-1 3715
2 Poractant alfa Approved Phase 4 129069-19-8
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3 50-02-2 5743
4
Zinc Approved, Investigational Phase 4 7440-66-6 32051 23994
5
Progesterone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 57-83-0 5994
6
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1 15687-27-1 3672
7
Iodine Approved, Investigational Phase 4 7553-56-2 807
8
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3 22916-47-8 4189
9
Nystatin Approved, Vet_approved Phase 4 1400-61-9 11953884
10
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 77-92-9 311
11
Caffeine Approved, Nutraceutical Phase 4,Phase 3 58-08-2 2519
12
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 1406-16-2
13
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 3 67-97-0 10883523 5280795 6221
14
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 3 50-14-6 5280793
15
B-Carotene Approved, Nutraceutical Phase 4 7235-40-7 5280489
16 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
17 glucocorticoids Phase 4,Phase 3,Phase 2
18 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1
19 Central Nervous System Stimulants Phase 4,Phase 3
20 Chelating Agents Phase 4,Phase 3
21 Tocolytic Agents Phase 4,Phase 3,Phase 2
22 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
23 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
24 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
25 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
26 Hormones Phase 4,Phase 2,Phase 3,Phase 1
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
28 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
29 Anticoagulants Phase 4,Phase 3
30 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2
31 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
32 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1
33 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
34 Pulmonary Surfactants Phase 4,Phase 3,Phase 2
35 Purinergic P1 Receptor Antagonists Phase 4,Phase 3
36 Antioxidants Phase 4,Phase 3,Phase 2,Phase 1
37 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
38 Caffeine citrate Phase 4,Phase 3
39 Calcium, Dietary Phase 4,Phase 3,Phase 2
40 Progestins Phase 4,Phase 2,Phase 3,Phase 1
41 cadexomer iodine Phase 4
42 Dexamethasone acetate Phase 4,Phase 3 1177-87-3
43
protease inhibitors Phase 4,Phase 3
44 11-hydroxyprogesterone Phase 4,Phase 2,Phase 3,Phase 1
45 17-alpha-hydroxy-progesterone caproate Phase 4,Phase 2,Phase 3,Phase 1
46 Micronutrients Phase 4,Phase 3,Phase 2
47 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
48 Trace Elements Phase 4,Phase 3,Phase 2
49 HIV Protease Inhibitors Phase 4,Phase 3
50 Vitamins Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 332)

# Name Status NCT ID Phase Drugs
1 Withholding Feeds During Red Blood Cell Transfusion and TRAGI Unknown status NCT02132819 Phase 4
2 The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) Unknown status NCT01765998 Phase 4 Probiotic;Placebo
3 Cpap at Delivery Room for Preterm Infants Unknown status NCT01024361 Phase 4
4 Intragastric and Peritoneal Microdialysis in Infants With Necrotizing Enterocolitis (NEC) Completed NCT00332592 Phase 4
5 Probiotics to Prevent NEC - a Historical Control Study Completed NCT01670916 Phase 4
6 Early Versus Late Lactoferrin in Prevention of Neonatal Sepsis Completed NCT02959229 Phase 4 Lactoferrin;Placebo (for Lactoferrin)
7 Comparison of Lactobacillus Reuteri and Nystatin Prophylaxis on Candida Colonization and Infection in Very Low Birth Weight Infants Completed NCT01531192 Phase 4 Nystatin
8 Ibuprofen and Renal Function in Premature Infants Completed NCT00217191 Phase 4 Ibuprofen
9 MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine Completed NCT00809055 Phase 4 Caffeine citrate
10 Efficacy of 17 Alpha-hydroxyprogesterones Caproate for the Prevention of Preterm Delivery Completed NCT00331695 Phase 4 17 alpha-hydroxyprogesterones caproate
11 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV Completed NCT01604447 Phase 4
12 Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates Completed NCT01403623 Phase 4
13 A Randomised Controlled Trial of Iodide Supplementation in Preterm Infants Follow-up at 2 Years Completed NCT00638092 Phase 4 sodium iodide;Sodium Chloride
14 Impact of Oral Application of Gastrografin on the Meconium Evacuation in Very Low Birth Weight Infants Completed NCT01515696 Phase 4 Gastrografin;Sterile water
15 The Effect of β-Carotene, Vitamin D3 and Zinc on Hyaline Membrane Disease and Feeding Intolerance in Premature Neonates Recruiting NCT03366584 Phase 4 Dexamethasone
16 Pilot Study to Compare Fresh Frozen Plasma With 24-Hour Plasma in Babies Up to Age Six Months Recruiting NCT02774317 Phase 4
17 OPTIMIST-A Trial: Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on CPAP Recruiting NCT02140580 Phase 4
18 Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM) Terminated NCT00201656 Phase 4
19 Sodium Supplementation and Growth in Very Low Birth Weight Infants Terminated NCT01795638 Phase 4 Sodium chloride;Placebo
20 RCT of Postoperative Infections Following Caesarean Section Infections Following Caesarean Section Withdrawn NCT02009098 Phase 4 Cefuroxime
21 Comparing Ibuprofen And Indomethacin For The Treatment Of The Patent Ductus Arteriosus in Very Premature Babies Withdrawn NCT00470743 Phase 4 Ibuprofen;Indomethacin
22 Effect of Saccharomyces Boulardii on Necrotizing Enterocolitis in Very Low Birth Weight Infants Unknown status NCT01315821 Phase 3 Saccharomyces boulardii;Placebo
23 Randomized Study of Pessary Versus Standard Management in Women With Increased Chance of Premature Birth Unknown status NCT00735137 Phase 3
24 Cysteine Supplementation in Critically Ill Neonates Unknown status NCT00254176 Phase 2, Phase 3
25 Efficacy Study of Hypothermia Plus Magnesium Sulphate(MgSO4) in the Management of Term and Near Term Babies With Hypoxic Ischemic Encephalopathy Unknown status NCT01646619 Phase 3 Magnesium Sulphate;Placebo
26 Lactobacillus Reuteri for Prevention of Necrotizing Enterocolitis in Very Low-birth Weight Infants Completed NCT01531179 Phase 3 Lactobacillus reuteri;Placebo
27 Probiotics in the Management of Necrotizing Enterocolitis in HIV-exposed Premature Infants Completed NCT01868737 Phase 3
28 The Efficacy of Symbiotic on Cytokines Completed NCT01899677 Phase 3 symbiotic
29 Effect of Oral Probiotic Supplementation on The Rate of Hospital Acquired Infection and Necrotizing Enterocolitis in Preterm Very Low Birth Weight Infants Completed NCT01340469 Phase 3
30 Role of Probiotics for Prevention of NEC in Preterm VLBW Infants Completed NCT02650869 Phase 3
31 Effect of Vitamin A in the Treatment of Neonatal Sepsis and Necrotizing Enterocolitis Completed NCT00707785 Phase 3
32 A Single Blinded Study on the Effect of Saccharomyces Boulardii CNCM I-745 on Growth and Development in Preterm Infants Completed NCT02310425 Phase 3 S. boulardii;Placebo
33 Progesterone Vaginal Pessary for Prevention of Preterm Twin Birth Completed NCT02350231 Phase 2, Phase 3 The progesterone vaginal pessary;Tonics group
34 Prevention Trial of Nosocomial Infections in Neutropenic Prematures With G-CSF Completed NCT00213759 Phase 3 filgrastim;dextrose 5%
35 Ursodiol for Treating Parenteral Nutrition Associated Cholestasis in Neonates Completed NCT00846963 Phase 2, Phase 3 Ursodiol;placebo
36 Intravenous Immunoglobulin in Prevention of Preterm Neonatal Sepsis Completed NCT02954926 Phase 3 IVIG
37 Trial of Indomethacin Prophylaxis in Preterm Infants (TIPP) Completed NCT00009646 Phase 3 indomethacin;Indomethacin;Placebo
38 PREGNANT Short Cervix Trial Completed NCT00615550 Phase 3 progesterone;placebo
39 A Trial Evaluating the Role of Sildenafil in the Treatment of Fetal Growth Restriction Completed NCT02590536 Phase 3 Sildenafil citrate;placebo
40 Intravenous Immune Globulin (IVIG) to Prevent Neonatal Infection Completed NCT01203345 Phase 2, Phase 3 IVIG;Placebo
41 17OHP for Reduction of Neonatal Morbidity Due to Preterm Birth (PTB) in Twin and Triplet Pregnancies Completed NCT00163020 Phase 2, Phase 3 17-alpha-hydroxyprogesterone caproate injectable;Placebo
42 Caffeine for Apnea of Prematurity (CAP) Completed NCT00182312 Phase 3 Caffeine citrate injection
43 NIV Strategies for RDS in Preterm Infants. NIV (Non Invasive Ventilation), RDS (Respiratory Distress Syndrome) Completed NCT02259400 Phase 2, Phase 3
44 Surfactant Positive Airway Pressure and Pulse Oximetry Trial Completed NCT00233324 Phase 3 Surfactant;Supplemental oxygen with target saturation of 85 to 89%;Supplemental oxygen with target saturation of 91 to 95%
45 Fluconazole Prophylaxis for the Prevention of Candidiasis in Infants Less Than 750 Grams Birthweight Completed NCT00734539 Phase 3 fluconazole;placebo
46 Pentoxifylline and Late Onset Sepsis in Preterm Infants Completed NCT02163174 Phase 3 Pentoxifylline (PTX);Placebo
47 High Versus Low Dose of Caffeine for Apnea of Prematurity Completed NCT02103777 Phase 3 Caffeine citrate
48 Glutamine Supplementation to Prevent Death or Infection in Extremely Premature Infants Completed NCT00005775 Phase 3 Glutamine;Placebo
49 Echocardiographically Guided Versus Standard Ibuprofen Treatment for Patent Ductus Arteriosus Completed NCT01593163 Phase 3 Ibuprofen EchoG;Standard ibuprofen treatment
50 High Dose Folic Acid Supplementation Throughout Pregnancy for Preeclampsia Prevention Completed NCT01355159 Phase 3 Folic Acid 4 mg;Placebo

Search NIH Clinical Center for Perinatal Necrotizing Enterocolitis

Cochrane evidence based reviews: enterocolitis, necrotizing

Genetic Tests for Perinatal Necrotizing Enterocolitis

Anatomical Context for Perinatal Necrotizing Enterocolitis

MalaCards organs/tissues related to Perinatal Necrotizing Enterocolitis:

38
Heart, Breast, Colon, Brain, Lung, Neutrophil, Cervix

Publications for Perinatal Necrotizing Enterocolitis

Articles related to Perinatal Necrotizing Enterocolitis:

(show top 50) (show all 204)
# Title Authors Year
1
Necrotizing enterocolitis in the setting of milk allergy after pediatric living donor liver transplantation. ( 29218832 )
2018
2
Necrotizing Enterocolitis in Infants with Hypoplastic Left Heart Syndrome Following Stage 1 Palliation or Heart Transplant. ( 29392349 )
2018
3
Routine Supplementation of Lactobacillus rhamnosus GG and Risk of Necrotizing Enterocolitis in Very Low Birth Weight Infants. ( 29402455 )
2018
4
Necrotizing enterocolitis as a prognostic factor for the neurodevelopmental outcome of preterm infants - match control study after 2years. ( 29409620 )
2018
5
Significance of dynamic evolution of TNF-I+, IL-6 and intestinal fatty acid-binding protein levels in neonatal necrotizing enterocolitis. ( 29399120 )
2018
6
Necrotizing Enterocolitis Cases Associated with Nosocomial Enterovirus Transmission in a Neonatal Unit. ( 29389824 )
2018
7
Bowel Ultrasound for the Diagnosis of Necrotizing Enterocolitis: A Meta-analysis. ( 29369246 )
2018
8
Vital signs analysis algorithm detects inflammatory response in premature infants with late onset sepsis and necrotizing enterocolitis. ( 29351876 )
2018
9
Technical aspects of abdominal ultrasound and color Doppler assessment of bowel viability in necrotizing enterocolitis. ( 29368011 )
2018
10
Clostridial strain-specific characteristics associated with necrotizing enterocolitis. ( 29352082 )
2018
11
Targeting the PXR-TLR4 signaling pathway to reduce intestinal inflammation in an experimental model of necrotizing enterocolitis. ( 29360809 )
2018
12
Expert consensus to weight an adherence score for audit and feedback of practices that prevent necrotizing enterocolitis in very low birth weight infants. ( 29422156 )
2018
13
High prevalence of cytomegalovirus infection in surgical intestinal specimens from infants with necrotizing enterocolitis and spontaneous intestinal perforation: A retrospective observational study. ( 28633098 )
2017
14
A functional ATG16L1 (T300A) variant is associated with necrotizing enterocolitis in premature infants. ( 27893720 )
2017
15
Association of single nucleotide polymorphisms of IL23R and IL17 with necrotizing enterocolitis in premature infants. ( 28224332 )
2017
16
Late presentation of necrotizing enterocolitis associated with rotavirus infection in a term infant with hyperinsulinism on octreotide therapy: A case report. ( 28984754 )
2017
17
Neonatal Mice with Necrotizing Enterocolitis-like Injury Develop Thrombocytopenia despite Increased Megakaryopoiesis. ( 28085792 )
2017
18
Antenatal Exposure to Magnesium Sulfate and Spontaneous Intestinal Perforation and Necrotizing Enterocolitis in Extremely Preterm Neonates. ( 28494498 )
2017
19
Comment on: Maternal pre-eclampsia as a risk factor for necrotizing enterocolitis. ( 28911253 )
2017
20
Hydrogen sulfide provides intestinal protection during a murine model of experimental necrotizing enterocolitis. ( 29338840 )
2017
21
Insulin-like growth factor I reduces the occurrence of necrotizing enterocolitis by reducing inflammatory response and protecting intestinal mucosal barrier in neonatal rats model. ( 29131241 )
2017
22
Blood Level of Inter-Alpha Inhibitor Proteins Distinguishes Necrotizing Enterocolitis From Spontaneous Intestinal Perforation. ( 27745748 )
2017
23
Severe hemolysis after plasma transfusion in a neonate with necrotizing enterocolitis, Clostridium perfringens infection, and red blood cell T-polyagglutination. ( 28643465 )
2017
24
Late Presentation of Fulminant Necrotizing Enterocolitis in a Child with Hyperinsulinism on Octreotide Therapy. ( 26867223 )
2016
25
Necrotizing enterocolitis is associated with earlier achievement of enteral autonomy in children with short bowel syndrome. ( 26700691 )
2016
26
Urinary Intestinal Fatty Acid-Binding Protein Can Distinguish Necrotizing Enterocolitis from Sepsis in Early Stage of the Disease. ( 27110575 )
2016
27
The antecedents and correlates of necrotizing enterocolitis and spontaneous intestinal perforation among infants born before the 28th week of gestation. ( 27197933 )
2016
28
Smad7 interrupts TGF-I^ signaling in intestinal macrophages and promotes inflammatory activation of these cells during necrotizing enterocolitis. ( 26859364 )
2016
29
NOD2 Loss-of-Function Mutations and Risks of Necrotizing Enterocolitis or Focal Intestinal Perforation in Very Low-birth-weight Infants. ( 26752461 )
2016
30
Surgical Necrotizing Enterocolitis versus Spontaneous Intestinal Perforation in White Matter Injury on Brain Magnetic Resonance Imaging. ( 27105356 )
2016
31
Toll-like receptor 4-mediated lymphocyte influx induces neonatal necrotizing enterocolitis. ( 26690704 )
2016
32
Necrotizing Enterocolitis Is Not Associated With Sequence Variants in Antioxidant Response Genes in Premature Infants. ( 26426434 )
2016
33
Pulmonary Epithelial TLR4 Activation Leads to Lung Injury in Neonatal Necrotizing Enterocolitis. ( 27307558 )
2016
34
Intestinal fatty acid-binding protein as a diagnostic marker for complicated and uncomplicated necrotizing enterocolitis: a prospective cohort study. ( 25793701 )
2015
35
Intestinal vascular endothelial growth factor is decreased in necrotizing enterocolitis. ( 25659996 )
2015
36
Capsular profiling of the Cronobacter genus and the association of specific Cronobacter sakazakii and C. malonaticus capsule types with neonatal meningitis and necrotizing enterocolitis. ( 26449318 )
2015
37
Toll-like receptor-4 in human and mouse colonic epithelium is developmentally regulated: a possible role in necrotizing enterocolitis. ( 25521917 )
2015
38
Comparative MiRNA Expressional Profiles and Molecular Networks in Human Small Bowel Tissues of Necrotizing Enterocolitis and Spontaneous Intestinal Perforation. ( 26274503 )
2015
39
Disruptions of the intestinal microbiome in necrotizing enterocolitis, short bowel syndrome, and Hirschsprung's associated enterocolitis. ( 26528281 )
2015
40
Association of neonatal necrotizing enterocolitis with myeloid differentiation-2 and GM2 activator protein genetic polymorphisms. ( 25816011 )
2015
41
A Novel Pore-Forming Toxin in Type A Clostridium perfringens Is Associated with Both Fatal Canine Hemorrhagic Gastroenteritis and Fatal Foal Necrotizing Enterocolitis. ( 25853427 )
2015
42
TIMP-1 inhibition of occludin degradation in Caco-2 intestinal cells: a potential protective role in necrotizing enterocolitis. ( 25665057 )
2015
43
Necrotizing Enterocolitis and Central Line Associated Blood Stream Infection Are Predictors of Growth Outcomes in Infants with Short Bowel Syndrome. ( 25841540 )
2015
44
Spontaneous Intestinal Perforation and Necrotizing Enterocolitis: A 16-Year Retrospective Study from a Single Center. ( 25643249 )
2015
45
Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis. ( 25448524 )
2015
46
Serologic Intestinal-Fatty Acid Binding Protein in Necrotizing Enterocolitis Diagnosis: A Meta-Analysis. ( 26798632 )
2015
47
SIGIRR genetic variants in premature infants with necrotizing enterocolitis. ( 25963006 )
2015
48
Oral antibiotics increase blood neutrophil maturation and reduce bacteremia and necrotizing enterocolitis in the immediate postnatal period of preterm pigs. ( 26561386 )
2015
49
Feeding associated neonatal necrotizing enterocolitis (Primary NEC) is an inflammatory bowel disease. ( 24406172 )
2014
50
Vasculitis as Part of the Fetal Response to Acute Chorioamnionitis Likely Plays a Role in the Development of Necrotizing Enterocolitis and Spontaneous Intestinal Perforation in Premature Neonates. ( 24819242 )
2014

Variations for Perinatal Necrotizing Enterocolitis

Expression for Perinatal Necrotizing Enterocolitis

Search GEO for disease gene expression data for Perinatal Necrotizing Enterocolitis.

Pathways for Perinatal Necrotizing Enterocolitis

Pathways related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14 CRP CXCL8 EGF HBEGF IL1B IL6
2
Show member pathways
13.41 CXCL8 EGF IL1B IL6 THPO TLR4
3
Show member pathways
13.28 CXCL8 EGF HBEGF IL1B IL6 PLA2G7
4
Show member pathways
13.18 EGF HBEGF IL1B TLR4 TLR9 TNF
5
Show member pathways
12.96 CXCL8 IL1B IL6 SIGIRR TLR4 TLR9
6
Show member pathways
12.8 CXCL8 IL1B IL6 TLR4 TLR9 TNF
7
Show member pathways
12.62 IL1B SIGIRR TLR4 TLR9 TNF
8
Show member pathways
12.59 EGF IL1B IL6 THPO TLR4 TLR9
9
Show member pathways
12.57 IL1B IL6 TLR4 TNF
10
Show member pathways
12.54 CXCL8 IL6 TLR4 TNF
11
Show member pathways
12.5 CXCL8 IL1B IL6 TLR4 TLR9 TNF
12
Show member pathways
12.34 CRP IL1B IL6 TNF
13
Show member pathways
12.33 CXCL8 IL1B IL6 TNF
14
Show member pathways
12.28 CXCL8 IL6 TLR4 TLR9 TNF
15
Show member pathways
12.26 CXCL8 IL1B IL6 TLR4 TNF
16 12.23 IL1B IL6 TLR4 TLR9 TNF
17 12.2 CXCL8 IL1B IL6 TNF
18
Show member pathways
12.19 CXCL8 IL1B IL6 TNF
19 12.17 EGF IL6 TLR4 TLR9 TNF
20 12.02 CXCL8 IL1B IL6 TNF
21
Show member pathways
12 IL1B TLR4 TLR9
22 12 CXCL8 IL1B IL6 TLR4 TNF
23 11.97 IL6 THPO TNF
24 11.95 CXCL8 IL1B IL6 TNF
25
Show member pathways
11.95 CXCL8 IL1B IL6 TLR4 TLR9 TNF
26 11.93 IL1B IL6 TNF
27 11.93 IL1B IL6 THPO TNF
28 11.93 EGF HBEGF IL6 THPO
29 11.92 CXCL8 IL1B IL6
30 11.92 CXCL8 IL1B TLR4 TNF
31 11.89 EGF IL6 TLR4
32
Show member pathways
11.89 IL1B IL6 TLR4 TLR9
33
Show member pathways
11.89 IL1B IL6 TLR4 TLR9 TNF
34 11.86 CXCL8 IL1B IL6 TLR4
35
Show member pathways
11.85 CXCL8 IL6 TLR4
36 11.84 CXCL8 IL1B IL6 TLR4 TNF
37 11.78 IL1B IL6 TLR9 TNF
38 11.76 CXCL8 IL1B IL6 TLR4 TNF
39 11.74 CXCL8 EGF HBEGF
40 11.72 IL6 TLR4 TLR9 TNF
41 11.69 CXCL8 HBEGF IL6
42
Show member pathways
11.68 CXCL8 IL1B IL6 TNF
43 11.65 CXCL8 IL1B IL6 TLR4 TNF
44 11.57 HBEGF IL6 TNF
45 11.54 IL1B TLR4 TNF
46 11.54 CXCL8 IL1B IL6 TNF
47 11.51 IL1B IL6 TNF
48 11.36 IL1B IL6 TNF
49 11.36 IL1B IL6 TLR9 TNF
50 11.35 CXCL8 EGF IL1B IL6 TNF

GO Terms for Perinatal Necrotizing Enterocolitis

Cellular components related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 CRP CXCL8 EGF HBEGF IL1B IL6
2 extracellular space GO:0005615 9.36 CRP CXCL8 EGF HBEGF IL1B IL6

Biological processes related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.96 EGF HBEGF IL1B TNF
2 regulation of receptor activity GO:0010469 9.95 CXCL8 HBEGF IL1B IL6 THPO TNF
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.91 IL1B TLR4 TLR9 TNF
4 positive regulation of protein kinase B signaling GO:0051897 9.88 EGF HBEGF THPO TNF
5 positive regulation of DNA binding transcription factor activity GO:0051091 9.87 IL1B IL6 TNF
6 inflammatory response GO:0006954 9.87 CRP CXCL8 IL1B IL6 TLR4 TLR9
7 defense response to Gram-positive bacterium GO:0050830 9.85 CRP IL6 TNF
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.83 EGF HBEGF IL6
9 defense response to Gram-negative bacterium GO:0050829 9.83 IL6 TLR4 TLR9
10 cellular response to lipopolysaccharide GO:0071222 9.83 CXCL8 IL6 TLR4 TNF
11 positive regulation of inflammatory response GO:0050729 9.81 PLA2G7 TLR4 TLR9
12 activation of MAPK activity GO:0000187 9.81 EGF IL1B TLR4 TNF
13 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 IL1B IL6 TLR4 TLR9 TNF
14 positive regulation of gene expression GO:0010628 9.8 CRP EGF IL1B IL6 TLR4 TLR9
15 positive regulation of smooth muscle cell proliferation GO:0048661 9.79 HBEGF IL6 TNF
16 positive regulation of interferon-gamma production GO:0032729 9.77 IL1B TLR4 TNF
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.76 IL1B TLR4 TNF
18 positive regulation of JNK cascade GO:0046330 9.76 IL1B TLR4 TLR9 TNF
19 acute-phase response GO:0006953 9.72 CRP IL6 SIGIRR
20 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 IL1B TLR4 TNF
21 embryonic digestive tract development GO:0048566 9.7 CXCL8 TNF
22 negative regulation of lipid catabolic process GO:0050995 9.7 IL1B TNF
23 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.69 IL1B TNF
24 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.69 IL1B TNF
25 negative regulation of ERBB signaling pathway GO:1901185 9.68 EGF HBEGF
26 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.68 TLR4 TLR9
27 response to molecule of bacterial origin GO:0002237 9.68 CXCL8 TLR9
28 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.67 IL1B TNF
29 I-kappaB phosphorylation GO:0007252 9.67 TLR4 TLR9
30 regulation of cytokine secretion GO:0050707 9.67 TLR4 TLR9
31 negative regulation of interleukin-6 production GO:0032715 9.67 TLR4 TLR9 TNF
32 positive regulation of interleukin-8 production GO:0032757 9.67 IL1B TLR4 TLR9 TNF
33 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.66 IL1B TLR9
34 positive regulation of chemokine biosynthetic process GO:0045080 9.65 IL1B TNF
35 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.64 TLR4 TNF
36 regulation of establishment of endothelial barrier GO:1903140 9.63 IL1B TNF
37 positive regulation of interferon-beta biosynthetic process GO:0045359 9.62 TLR4 TLR9
38 positive regulation of fever generation GO:0031622 9.61 IL1B TNF
39 negative regulation of lipid storage GO:0010888 9.61 CRP IL6 TNF
40 sequestering of triglyceride GO:0030730 9.6 IL1B TNF
41 negative regulation of chemokine biosynthetic process GO:0045079 9.57 IL6 SIGIRR
42 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.56 IL1B TNF
43 positive regulation of NF-kappaB import into nucleus GO:0042346 9.46 IL1B TLR4 TLR9 TNF
44 positive regulation of chemokine production GO:0032722 9.26 IL6 TLR4 TLR9 TNF
45 positive regulation of interleukin-6 production GO:0032755 9.02 IL1B IL6 TLR4 TLR9 TNF
46 immune response GO:0006955 10.03 CXCL8 IL1B IL6 TLR4 TNF

Molecular functions related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 EGF HBEGF IL6 THPO
2 interleukin-1 receptor binding GO:0005149 9.16 IL1B TLR9
3 cytokine activity GO:0005125 9.02 CXCL8 IL1B IL6 THPO TNF

Sources for Perinatal Necrotizing Enterocolitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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