MCID: PRN019
MIFTS: 31

Perinatal Necrotizing Enterocolitis malady

Rare diseases, Fetal diseases, Gastrointestinal diseases, Neuronal diseases, Cancer diseases categories

Aliases & Classifications for Perinatal Necrotizing Enterocolitis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 61UMLS, 56SNOMED-CT, 39NCIt, 33MeSH, 26ICD10 via Orphanet, 25ICD10
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Aliases & Descriptions for Perinatal Necrotizing Enterocolitis:

Name: Perinatal Necrotizing Enterocolitis 8 10
Necrotizing Enterocolitis 8 42 48
Enterocolitis, Necrotizing 42 61
Enterocolitis Necrotizing 8 44
Necrotizing Enterocolitis in Fetus or Newborn 8
 
Pseudomembranous Enterocolitis in Newborn 8
Perinatal Necrotising Enterocolitis 8
Carcinoma, Neuroendocrine 61
Nec 42


Classifications:



External Ids:

Disease Ontology8 DOID:8677
NCIt39 C84915
MeSH33 D020345
Orphanet48 391673
ICD10 via Orphanet26 P77
ICD1025 P77

Summaries for Perinatal Necrotizing Enterocolitis

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NIH Rare Diseases:42 Necrotizing enterocolitis (nec) is a condition characterized by variable injury or damage to the intestinal tract, causing death of intestinal tissue. the condition most often occurs in premature newborns, but it may also occur in term or near-term babies. signs and symptoms may include abdominal distension, bloody stools, vomiting bile-stained fluid, and pneumatosis intestinalis (gas in the bowel wall) identified on abdominal x-ray. affected infants occasionally have temperature instability, lethargy, or other findings of sepsis. the exact cause of nec is unknown. treatment involves stopping feedings, passing a small tube into the stomach to relieve gas, and giving intravenous fluids and antibiotics. surgery may be needed if there is perforated or necrotic (dead) bowel tissue. about 60-80% of affected newborns survive the condition. last updated: 2/4/2013

MalaCards based summary: Perinatal Necrotizing Enterocolitis, also known as necrotizing enterocolitis, is related to chorioamnionitis and inflammatory bowel disease. An important gene associated with Perinatal Necrotizing Enterocolitis is HBEGF (heparin-binding EGF-like growth factor), and among its related pathways are Proteoglycans in cancer and Development Slit Robo signaling. The compounds tgf beta1 and chlorate have been mentioned in the context of this disorder. Related mouse phenotypes are skeleton and respiratory system.

Related Diseases for Perinatal Necrotizing Enterocolitis

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Graphical network of the top 20 diseases related to Perinatal Necrotizing Enterocolitis:



Diseases related to perinatal necrotizing enterocolitis

Symptoms for Perinatal Necrotizing Enterocolitis

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Drugs & Therapeutics for Perinatal Necrotizing Enterocolitis

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Drug clinical trials:

Search ClinicalTrials for Perinatal Necrotizing Enterocolitis

Search NIH Clinical Center for Perinatal Necrotizing Enterocolitis

Genetic Tests for Perinatal Necrotizing Enterocolitis

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Anatomical Context for Perinatal Necrotizing Enterocolitis

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Animal Models for Perinatal Necrotizing Enterocolitis or affiliated genes

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MGI Mouse Phenotypes related to Perinatal Necrotizing Enterocolitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.8SERPINH1, HBEGF, TLR4
2MP:00053888.5SERPINH1, HBEGF, TLR4

Publications for Perinatal Necrotizing Enterocolitis

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Variations for Perinatal Necrotizing Enterocolitis

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Expression for genes affiliated with Perinatal Necrotizing Enterocolitis

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Search GEO for disease gene expression data for Perinatal Necrotizing Enterocolitis.

Pathways for genes affiliated with Perinatal Necrotizing Enterocolitis

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Pathways related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4HBEGF, TLR4
2
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion59
Pathogenic Escherichia coli infection36
Cytoskeleton remodeling Slit Robo signaling
9.4HBEGF, TLR4

Compounds for genes affiliated with Perinatal Necrotizing Enterocolitis

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Compounds related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

(show all 37)
idCompoundScoreTop Affiliating Genes
1tgf beta1449.7HBEGF, TLR4
2chlorate449.5LTF, HBEGF
3pneumococcal449.5TLR4, LTF
4zymosan449.5LTF, TLR4
5polymyxin b449.5LTF, TLR4
6anti-fungal449.5TLR4, LTF
7c2ceramide449.5TLR4, LTF
8chondroitin sulfate44 2410.5HBEGF, LTF
9sb 20358044 6010.4HBEGF, TLR4
10carbohydrates449.4TLR4, LTF
11mannose449.4LTF, TLR4
12heparan sulfate44 2410.4HBEGF, LTF
13endotoxin449.4TLR4, LTF
14fmlp449.3TLR4, LTF
15nacl449.3LTF, HBEGF
16vitamin a44 24 1111.3HBEGF, LTF
17nitric oxide44 24 1111.1HBEGF, TLR4, SERPINH1
18polyacrylamide449.1SERPINH1, LTF
19phospholipid449.1HBEGF, TLR4
20histamine44 28 2411.1TLR4, LTF
21atp44 2810.1SERPINH1, HBEGF, TLR4
22ascorbic acid44 2410.1LTF, SERPINH1
23latex449.0TLR4, LTF, HBEGF
24n acetylcysteine449.0TLR4, HBEGF, LTF
25polysaccharide449.0LTF, TLR4, HBEGF
26fibrinogen449.0TLR4, HBEGF, LTF
27actinomycin d449.0TLR4, LTF, HBEGF
28pge2449.0LTF, HBEGF, TLR4
29h2o2449.0TLR4, LTF, HBEGF
30dexamethasone44 50 28 1112.0LTF, HBEGF, TLR4
31alanine448.9LTF, TLR4, HBEGF
32retinoic acid44 249.9TLR4, LTF, HBEGF
33cysteine448.9LTF, TLR4, HBEGF
34cyclosporin a44 28 6010.9LTF, SERPINH1, TLR4
35tyrosine448.7TLR4, HBEGF, SERPINH1
36vegf448.4TLR4, HBEGF, SERPINH1, LTF
37serine448.4TLR4, HBEGF, SERPINH1, LTF

GO Terms for genes affiliated with Perinatal Necrotizing Enterocolitis

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Cellular components related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.5LTF, SERPINH1, HBEGF

Biological processes related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.1LTF, TLR4
2positive regulation of NF-kappaB transcription factor activityGO:00510928.8LTF, TLR4

Molecular functions related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00082019.1LTF, HBEGF

Sources for Perinatal Necrotizing Enterocolitis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet