NEC
MCID: PRN019
MIFTS: 42

Perinatal Necrotizing Enterocolitis (NEC) malady

Categories: Rare diseases, Fetal diseases, Gastrointestinal diseases

Aliases & Classifications for Perinatal Necrotizing Enterocolitis

Aliases & Descriptions for Perinatal Necrotizing Enterocolitis:

Name: Perinatal Necrotizing Enterocolitis 12 14
Necrotizing Enterocolitis 12 50 56 14 69
Enterocolitis, Necrotizing 50 42
Enterocolitis Necrotizing 12 52
Necrotizing Enterocolitis in Fetus or Newborn 12
Pseudomembranous Enterocolitis in Newborn 12
Perinatal Necrotising Enterocolitis 12
Nec 50

Characteristics:

Orphanet epidemiological data:

56
necrotizing enterocolitis
Prevalence: 1-5/10000 (Worldwide); Age of onset: Neonatal; Age of death: infantile;

Classifications:



External Ids:

Disease Ontology 12 DOID:8677
MeSH 42 D020345
NCIt 47 C84915
Orphanet 56 ORPHA391673
ICD10 via Orphanet 34 P77
ICD10 33 P77
UMLS 69 C0520459

Summaries for Perinatal Necrotizing Enterocolitis

NIH Rare Diseases : 50 necrotizing enterocolitis (nec) is a condition characterized by variable injury or damage to the intestinal tract, causing death of intestinal tissue. the condition most often occurs in premature newborns, but it may also occur in term or near-term babies. signs and symptoms may include abdominal distension, bloody stools, vomiting bile-stained fluid, and pneumatosis intestinalis (gas in the bowel wall) identified on abdominal x-ray. affected infants occasionally have temperature instability, lethargy, or other findings of sepsis. the exact cause of nec is unknown. treatment involves stopping feedings, passing a small tube into the stomach to relieve gas, and giving intravenous fluids and antibiotics. surgery may be needed if there is perforated or necrotic (dead) bowel tissue. about 60-80% of affected newborns survive the condition. last updated: 2/4/2013

MalaCards based summary : Perinatal Necrotizing Enterocolitis, also known as necrotizing enterocolitis, is related to intestinal perforation and intussusception. An important gene associated with Perinatal Necrotizing Enterocolitis is FABP2 (Fatty Acid Binding Protein 2), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Indomethacin and Poractant alfa have been mentioned in the context of this disorder. Related phenotype is immune system.

Wikipedia : 71 Necrotizing enterocolitis (NEC) is a medical condition primarily seen in premature infants, where... more...

Related Diseases for Perinatal Necrotizing Enterocolitis

Diseases related to Perinatal Necrotizing Enterocolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 249)
id Related Disease Score Top Affiliating Genes
1 intestinal perforation 10.4
2 intussusception 10.2 IL1B TNF
3 coloboma of iris 10.2 CRP IL6
4 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.2 IL6 TNF
5 lateral cystocele 10.2 CXCL8 IL6 TLR4
6 vitreoretinopathy, neovascular inflammatory 10.2 CXCL8 IL6 SERPINH1
7 gastric leiomyoma 10.2 IL1B IL6 TLR4
8 premature menopause 10.1 CRP EGF IL6
9 oculomotor nerve paralysis 10.1 CXCL8 IL1B IL6
10 common peroneal nerve lesion 10.1 CXCL8 IL1B IL6
11 brain injury 10.1 CRP HBEGF IL6
12 appendiceal l-cell glucagon-like peptide producing tumor 10.1 CRP CXCL8 TLR4
13 carbuncle 10.1 CXCL8 IL1B IL6
14 aortic coarctation 10.1 IL6 TLR4 TNF
15 blind hypotensive eye 10.1 CRP IL6 THPO
16 megaloblastic anemia 10.1 CRP IL1B TLR4
17 gait apraxia 10.1 CRP IL6 TLR4
18 tau syndrome 10.1 IL1B TNF
19 uterine corpus dissecting leiomyoma 10.1 CXCL8 EGF HBEGF IL6
20 fallopian tube serous adenocarcinoma 10.1 CRP CXCL8 IL6
21 laryngotracheoesophageal cleft type 2 10.1 CRP IL1B IL6
22 usher syndrome, type 2a 10.1 IL6 LY96 TLR4
23 dyslexia 5 10.1 IL6 TNF
24 mixed mineral dust pneumoconiosis 10.1 CRP CXCL8 IL6
25 breast apocrine carcinoma in situ 10.1 CXCL8 IL1B IL6
26 thymic neuroendocrine carcinoma 10.1 CXCL8 IL6 TNF
27 allergic bronchopulmonary aspergillosis 10.1 CRP CXCL8 IL6
28 long bones of lower limb cancer 10.1 EGF IL6 TNF
29 esophagus lymphoma 10.1 CXCL8 IL6 TNF
30 rickettsialpox 10.1 IL1B TLR4 TNF
31 mansonelliasis 10.1 IL6 TLR4 TNF
32 trichomalacia 10.1 CXCL8 IL6 TNF
33 hidradenitis 10.1 CRP CXCL8 IL1B
34 gastric dilatation 10.1 CXCL8 IL6 TNF
35 anal paget's disease 10.1 IL1B IL6 TNF
36 bipolar i disorder 10.1 IL1B IL6 TNF
37 orthostatic proteinuria 10.1 CXCL8 IL6 TNF
38 tinea capitis 10.1 IL1B IL6 TNF
39 erb-duchenne and dejerine-klumpke palsies 10.1 CXCL8 IL6 TNF
40 dextrocardia 10.1 IL1B IL6 TNF
41 steroid dehydrogenase deficiency dental anomalies 10.1 IL1B IL6 TNF
42 wilkes stevenson syndrome 10.1 CRP CXCL8 IL1B
43 gonococcal endophthalmia 10.1 IL1B IL6 TNF
44 ectodermal dysplasia bartalos type 10.1 IL1B IL6 TNF
45 stocco dos santos syndrome 10.1 IL1B TNF
46 mineral metabolism disease 10.1 IL1B IL6 TNF
47 amyotrophic lateral sclerosis type 14 10.1 CXCL8 IL1B TNF
48 unilateral multicystic dysplastic kidney 10.1 CRP IL6 TNF
49 migraine with aura 10.1 IL1B IL6 TNF
50 bladder signet ring cell adenocarcinoma 10.1 IL1B IL6 TNF

Graphical network of the top 20 diseases related to Perinatal Necrotizing Enterocolitis:



Diseases related to Perinatal Necrotizing Enterocolitis

Symptoms & Phenotypes for Perinatal Necrotizing Enterocolitis

MGI Mouse Phenotypes related to Perinatal Necrotizing Enterocolitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.32 CRP EGF IL1B IL6 LY96 PLA2G7

Drugs & Therapeutics for Perinatal Necrotizing Enterocolitis

Drugs for Perinatal Necrotizing Enterocolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 224)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Indomethacin Approved, Investigational Phase 4,Phase 3,Phase 2 53-86-1 3715
2 Poractant alfa Approved Phase 4 129069-19-8
3
Progesterone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 57-83-0 5994
4
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1 15687-27-1 3672
5
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3 22916-47-8 4189
6
Nystatin Approved, Vet_approved Phase 4 1400-61-9 11953884
7
Caffeine Approved, Nutraceutical Phase 4,Phase 3 58-08-2 2519
8 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
9 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
10 Tocolytic Agents Phase 4,Phase 3,Phase 2
11 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
12 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
13 Hormones Phase 4,Phase 2,Phase 3,Phase 1
14 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
16 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2
17 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
18 Pulmonary Surfactants Phase 4,Phase 3,Phase 2
19 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1
20 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1
21 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
22 Calcium, Dietary Phase 4,Phase 3,Phase 2
23 Progestins Phase 4,Phase 2,Phase 3,Phase 1
24
Iodine Phase 4 7553-56-2 807
25 cadexomer iodine Phase 4
26 Chelating Agents Phase 4,Phase 3
27 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
28 Trace Elements Phase 4,Phase 3,Phase 2
29 Estrogen Antagonists Phase 4,Phase 2,Phase 3,Phase 1
30 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Phase 2
31 Estrogens Phase 4,Phase 2,Phase 3,Phase 1
32 11-hydroxyprogesterone Phase 4,Phase 2,Phase 3,Phase 1
33 17-alpha-hydroxy-progesterone caproate Phase 4,Phase 2,Phase 3,Phase 1
34 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
35 Anticoagulants Phase 4,Phase 3
36 Anti-Infective Agents, Local Phase 4
37 Antifungal Agents Phase 4,Phase 3
38 Ionophores Phase 4
39 Lactoferrin Phase 4
40 Purinergic P1 Receptor Antagonists Phase 4,Phase 3
41 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
42 Micronutrients Phase 4,Phase 3,Phase 2
43 Antitubercular Agents Phase 4,Phase 3,Phase 2
44 Caffeine citrate Phase 4,Phase 3
45 Central Nervous System Stimulants Phase 4,Phase 3
46 Acidophilus Nutraceutical Phase 4,Phase 3,Phase 2
47 Bifidobacterium Nutraceutical Phase 4,Phase 3,Phase 2
48 Citrate Nutraceutical Phase 4,Phase 3,Phase 2
49
Citric Acid Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 77-92-9 311
50 Caproate Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 290)
id Name Status NCT ID Phase
1 Withholding Feeds During Red Blood Cell Transfusion and TRAGI Unknown status NCT02132819 Phase 4
2 The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) Unknown status NCT01765998 Phase 4
3 Cpap at Delivery Room for Preterm Infants Unknown status NCT01024361 Phase 4
4 Intragastric and Peritoneal Microdialysis in Infants With Necrotizing Enterocolitis (NEC) Completed NCT00332592 Phase 4
5 Probiotics to Prevent NEC - a Historical Control Study Completed NCT01670916 Phase 4
6 Early Versus Late Lactoferrin in Prevention of Neonatal Sepsis Completed NCT02959229 Phase 4
7 Comparison of Lactobacillus Reuteri and Nystatin Prophylaxis on Candida Colonization and Infection in Very Low Birth Weight Infants Completed NCT01531192 Phase 4
8 Ibuprofen and Renal Function in Premature Infants Completed NCT00217191 Phase 4
9 MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine Completed NCT00809055 Phase 4
10 Efficacy of 17 Alpha-hydroxyprogesterones Caproate for the Prevention of Preterm Delivery Completed NCT00331695 Phase 4
11 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV Completed NCT01604447 Phase 4
12 Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates Completed NCT01403623 Phase 4
13 A Randomised Controlled Trial of Iodide Supplementation in Preterm Infants Follow-up at 2 Years Completed NCT00638092 Phase 4
14 Impact of Oral Application of Gastrografin on the Meconium Evacuation in Very Low Birth Weight Infants Completed NCT01515696 Phase 4
15 OPTIMIST-A Trial: Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on CPAP Recruiting NCT02140580 Phase 4
16 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part II Recruiting NCT01604421 Phase 4
17 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part I Recruiting NCT01604317 Phase 4
18 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part III Recruiting NCT01604434 Phase 4
19 Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM) Terminated NCT00201656 Phase 4
20 Sodium Supplementation and Growth in Very Low Birth Weight Infants Terminated NCT01795638 Phase 4
21 RCT of Postoperative Infections Following Caesarean Section Infections Following Caesarean Section Withdrawn NCT02009098 Phase 4
22 Comparing Ibuprofen And Indomethacin For The Treatment Of The Patent Ductus Arteriosus in Very Premature Babies Withdrawn NCT00470743 Phase 4
23 Effect of Saccharomyces Boulardii on Necrotizing Enterocolitis in Very Low Birth Weight Infants Unknown status NCT01315821 Phase 3
24 Randomized Study of Pessary Versus Standard Management in Women With Increased Chance of Premature Birth Unknown status NCT00735137 Phase 3
25 Cysteine Supplementation in Critically Ill Neonates Unknown status NCT00254176 Phase 2, Phase 3
26 Efficacy Study of Hypothermia Plus Magnesium Sulphate(MgSO4) in the Management of Term and Near Term Babies With Hypoxic Ischemic Encephalopathy Unknown status NCT01646619 Phase 3
27 Lactobacillus Reuteri for Prevention of Necrotizing Enterocolitis in Very Low-birth Weight Infants Completed NCT01531179 Phase 3
28 Probiotics in the Management of Necrotizing Enterocolitis in HIV-exposed Premature Infants Completed NCT01868737 Phase 3
29 The Efficacy of Symbiotic on Cytokines Completed NCT01899677 Phase 3
30 Role of Probiotics for Prevention of NEC in Preterm VLBW Infants Completed NCT02650869 Phase 3
31 Effect of Oral Probiotic Supplementation on The Rate of Hospital Acquired Infection and Necrotizing Enterocolitis in Preterm Very Low Birth Weight Infants Completed NCT01340469 Phase 3
32 Effect of Vitamin A in the Treatment of Neonatal Sepsis and Necrotizing Enterocolitis Completed NCT00707785 Phase 3
33 A Single Blinded Study on the Effect of Saccharomyces Boulardii CNCM I-745 on Growth and Development in Preterm Infants Completed NCT02310425 Phase 3
34 Prevention Trial of Nosocomial Infections in Neutropenic Prematures With G-CSF Completed NCT00213759 Phase 3
35 Progesterone Vaginal Pessary for Prevention of Preterm Twin Birth Completed NCT02350231 Phase 2, Phase 3
36 Ursodiol for Treating Parenteral Nutrition Associated Cholestasis in Neonates Completed NCT00846963 Phase 2, Phase 3
37 Trial of Indomethacin Prophylaxis in Preterm Infants (TIPP) Completed NCT00009646 Phase 3
38 Intravenous Immunoglobulin in Prevention of Preterm Neonatal Sepsis Completed NCT02954926 Phase 3
39 PREGNANT Short Cervix Trial Completed NCT00615550 Phase 3
40 Intravenous Immune Globulin (IVIG) to Prevent Neonatal Infection Completed NCT01203345 Phase 2, Phase 3
41 17OHP for Reduction of Neonatal Morbidity Due to Preterm Birth (PTB) in Twin and Triplet Pregnancies Completed NCT00163020 Phase 2, Phase 3
42 Caffeine for Apnea of Prematurity (CAP) Completed NCT00182312 Phase 3
43 NIV Strategies for RDS in Preterm Infants. NIV (Non Invasive Ventilation), RDS (Respiratory Distress Syndrome) Completed NCT02259400 Phase 2, Phase 3
44 Fluconazole Prophylaxis for the Prevention of Candidiasis in Infants Less Than 750 Grams Birthweight Completed NCT00734539 Phase 3
45 Glutamine Supplementation to Prevent Death or Infection in Extremely Premature Infants Completed NCT00005775 Phase 3
46 Canadian Oxygen Trial (COT) Completed NCT00637169 Phase 3
47 Nasal Intermittent Positive Pressure Ventilation in Premature Infants (NIPPV) Completed NCT00433212 Phase 3
48 Pentoxifylline and Late Onset Sepsis in Preterm Infants Completed NCT02163174 Phase 3
49 High Versus Low Dose of Caffeine for Apnea of Prematurity Completed NCT02103777 Phase 3
50 Omega-3 Fatty Acid Supplementation to Prevent Preterm Birth in High Risk Pregnancies Completed NCT00135902 Phase 3

Search NIH Clinical Center for Perinatal Necrotizing Enterocolitis

Cochrane evidence based reviews: enterocolitis, necrotizing

Genetic Tests for Perinatal Necrotizing Enterocolitis

Anatomical Context for Perinatal Necrotizing Enterocolitis

Publications for Perinatal Necrotizing Enterocolitis

Variations for Perinatal Necrotizing Enterocolitis

Expression for Perinatal Necrotizing Enterocolitis

Search GEO for disease gene expression data for Perinatal Necrotizing Enterocolitis.

Pathways for Perinatal Necrotizing Enterocolitis

Pathways related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 CRP CXCL8 EGF HBEGF IL1B IL6
2
Show member pathways
13.64 CXCL8 EGF IL1B IL6 LY96 THPO
3
Show member pathways
13.39 CXCL8 EGF IL1B IL6 THPO TLR4
4
Show member pathways
13.25 CXCL8 EGF HBEGF IL1B IL6 PLA2G7
5
Show member pathways
12.95 CXCL8 IL1B IL6 LY96 SIGIRR TLR4
6
Show member pathways
12.86 CXCL8 IL1B IL6 LY96 SIGIRR TLR4
7
Show member pathways
12.79 CXCL8 IL1B IL6 TLR4 TNF
8
Show member pathways
12.67 EGF IL1B IL6 THPO TLR4 TNF
9
Show member pathways
12.62 IL1B LY96 SIGIRR TLR4 TNF
10
Show member pathways
12.57 IL1B IL6 TLR4 TNF
11
Show member pathways
12.33 CRP IL1B IL6 TNF
12
Show member pathways
12.32 CXCL8 IL1B IL6 TNF
13
Show member pathways
12.25 IL1B LY96 TLR4 TNF
14 12.23 IL1B IL6 TLR4 TNF
15
Show member pathways
12.23 CXCL8 IL6 LY96 TLR4 TNF
16 12.18 EGF IL6 TLR4 TNF
17
Show member pathways
12.18 CXCL8 IL1B IL6 LY96 TLR4 TNF
18 12.17 CXCL8 IL1B IL6 TNF
19
Show member pathways
12.16 CXCL8 IL1B IL6 TNF
20
Show member pathways
12.06 CXCL8 IL1B IL6 LY96 TLR4 TNF
21 11.99 CXCL8 IL1B IL6 TNF
22 11.99 CXCL8 IL1B IL6 TLR4 TNF
23 11.97 IL6 THPO TNF
24
Show member pathways
11.96 IL1B IL6 TLR4 TNF
25 11.93 IL1B IL6 TNF
26 11.92 CXCL8 IL1B IL6
27 11.91 CXCL8 IL1B IL6 TNF
28
Show member pathways
11.9 IL1B IL6 TLR4
29 11.9 IL1B IL6 THPO TNF
30 11.89 EGF IL6 TLR4
31 11.89 EGF HBEGF IL6 THPO
32
Show member pathways
11.87 CXCL8 IL6 LY96 TLR4
33 11.86 CXCL8 IL1B IL6 TLR4 TNF
34 11.83 CXCL8 IL1B IL6 TLR4
35 11.83 CXCL8 IL1B LY96 TLR4 TNF
36 11.79 CXCL8 IL1B IL6 TLR4 TNF
37 11.77 IL1B IL6 TNF
38 11.75 CXCL8 EGF HBEGF
39 11.74 LY96 TLR4 TNF
40 11.73 IL6 TLR4 TNF
41 11.68 CXCL8 HBEGF IL6
42
Show member pathways
11.65 CXCL8 IL1B IL6 TNF
43 11.59 LY96 TLR4 TNF
44 11.56 HBEGF IL6 TNF
45 11.53 IL1B TLR4 TNF
46 11.52 CXCL8 IL1B IL6 TNF
47 11.49 IL1B IL6 TNF
48 11.45 CXCL8 EGF IL1B IL6 TNF
49 11.37 IL1B IL6 TNF
50 11.34 IL1B IL6 TLR4 TNF

GO Terms for Perinatal Necrotizing Enterocolitis

Cellular components related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 CRP CXCL8 EGF HBEGF IL1B IL6
2 extracellular space GO:0005615 9.36 CRP CXCL8 EGF HBEGF IL1B IL6
3 lipopolysaccharide receptor complex GO:0046696 9.16 LY96 TLR4

Biological processes related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

(show all 45)
id Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.96 EGF HBEGF IL1B TNF
2 positive regulation of gene expression GO:0010628 9.96 CRP IL1B IL6 TLR4 TNF
3 response to lipopolysaccharide GO:0032496 9.91 IL1B IL6 LY96 TLR4
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.9 IL6 THPO TLR4 TNF
5 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.86 IL1B IL6 TNF
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.84 EGF HBEGF IL6
7 apoptotic signaling pathway GO:0097190 9.83 LY96 TLR4 TNF
8 defense response to Gram-positive bacterium GO:0050830 9.83 CRP IL6 TNF
9 positive regulation of JNK cascade GO:0046330 9.82 IL1B TLR4 TNF
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.81 IL1B IL6 TLR4 TNF
11 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.8 LY96 TLR4 TNF
12 activation of MAPK activity GO:0000187 9.8 EGF IL1B TLR4 TNF
13 positive regulation of smooth muscle cell proliferation GO:0048661 9.79 HBEGF IL6 TNF
14 positive regulation of interferon-gamma production GO:0032729 9.76 IL1B TLR4 TNF
15 positive regulation of protein kinase B signaling GO:0051897 9.73 HBEGF IL6 THPO TNF
16 embryonic digestive tract development GO:0048566 9.7 CXCL8 TNF
17 acute-phase response GO:0006953 9.7 CRP IL6 SIGIRR
18 negative regulation of lipid catabolic process GO:0050995 9.69 IL1B TNF
19 necroptotic process GO:0070266 9.69 LY96 TLR4
20 toll-like receptor 4 signaling pathway GO:0034142 9.69 LY96 TLR4
21 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.68 IL1B TNF
22 negative regulation of ERBB signaling pathway GO:1901185 9.68 EGF HBEGF
23 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.68 IL1B TNF
24 MyD88-independent toll-like receptor signaling pathway GO:0002756 9.67 LY96 TLR4
25 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.67 IL1B TNF
26 positive regulation of chemokine biosynthetic process GO:0045080 9.66 IL1B TNF
27 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.65 TLR4 TNF
28 positive regulation of interleukin-8 production GO:0032757 9.65 IL1B TLR4 TNF
29 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 9.63 LY96 TLR4
30 regulation of establishment of endothelial barrier GO:1903140 9.63 IL1B TNF
31 positive regulation of NF-kappaB import into nucleus GO:0042346 9.63 IL1B TLR4 TNF
32 positive regulation of interleukin-6 production GO:0032755 9.62 IL1B IL6 TLR4 TNF
33 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.61 IL6 TNF
34 positive regulation of fever generation GO:0031622 9.59 IL1B TNF
35 sequestering of triglyceride GO:0030730 9.58 IL1B TNF
36 positive regulation of chemokine production GO:0032722 9.58 IL6 TLR4 TNF
37 detection of lipopolysaccharide GO:0032497 9.57 LY96 TLR4
38 positive regulation of nitric oxide biosynthetic process GO:0045429 9.56 IL1B IL6 TLR4 TNF
39 negative regulation of chemokine biosynthetic process GO:0045079 9.55 IL6 SIGIRR
40 cellular response to lipopolysaccharide GO:0071222 9.55 CXCL8 IL6 LY96 TLR4 TNF
41 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.54 IL1B TNF
42 negative regulation of lipid storage GO:0010888 9.54 CRP IL6 TNF
43 lipopolysaccharide-mediated signaling pathway GO:0031663 9.26 IL1B LY96 TLR4 TNF
44 inflammatory response GO:0006954 9.17 CRP CXCL8 IL1B IL6 LY96 TLR4
45 immune response GO:0006955 10.04 CXCL8 IL1B IL6 TLR4 TNF

Molecular functions related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 EGF HBEGF IL6 THPO
2 lipopolysaccharide receptor activity GO:0001875 9.16 LY96 TLR4
3 cytokine activity GO:0005125 9.02 CXCL8 IL1B IL6 THPO TNF

Sources for Perinatal Necrotizing Enterocolitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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