NEC
MCID: PRN019
MIFTS: 36

Perinatal Necrotizing Enterocolitis (NEC) malady

Fetal, Gastrointestinal categories

Summaries for Perinatal Necrotizing Enterocolitis

Sources:
43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Necrotizing enterocolitis (nec) is a condition characterized by variable injury or damage to the intestinal tract, causing death of intestinal tissue. the condition most often occurs in premature newborns, but it may also occur in term or near-term babies. signs and symptoms may include abdominal distension, bloody stools, vomiting bile-stained fluid, and pneumatosis intestinalis (gas in the bowel wall) identified on abdominal x-ray. affected infants occasionally have temperature instability, lethargy, or other findings of sepsis. the exact cause of nec is unknown. treatment involves stopping feedings, passing a small tube into the stomach to relieve gas, and giving intravenous fluids and antibiotics. surgery may be needed if there is perforated or necrotic (dead) bowel tissue. about 60-80% of affected newborns survive the condition. last updated: 2/4/2013

MalaCards: Perinatal Necrotizing Enterocolitis, also known as enterocolitis, necrotizing, is related to sepsis and patent ductus arteriosus. An important gene associated with Perinatal Necrotizing Enterocolitis is ZNF213 (zinc finger protein 213), and among its related pathways are Legionellosis and Rheumatoid arthritis. The compounds pge2 and estrogen have been mentioned in the context of this disorder. Affiliated tissues include small intestine, and related mouse phenotypes are integument and digestive/alimentary.

Aliases & Classifications for Perinatal Necrotizing Enterocolitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 43NIH Rare Diseases, 61UMLS, 40NCIt, 35MeSH, 57SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal
Anatomical: Gastrointestinal


Aliases & Descriptions:

perinatal necrotizing enterocolitis 8 10
enterocolitis, necrotizing 43 61
enterocolitis necrotizing 8 45
necrotizing enterocolitis 8 43
necrotizing enterocolitis in fetus or newborn 8
pseudomembranous enterocolitis in newborn 8
perinatal necrotising enterocolitis 8
nec 43


External Ids:

Disease Ontology8 DOID:8677
NCIt40 C84915
MeSH35 D020345
ICD1025 P77

Related Diseases for Perinatal Necrotizing Enterocolitis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Perinatal Necrotizing Enterocolitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1sepsis30.8TLR4, TNF, LTF, IL6, PLA2G7
2patent ductus arteriosus30.5OR7E87P, ZNF213
3bronchopulmonary dysplasia30.3PLA2G7
4chorioamnionitis30.1SERPINH1, IL6, LTF, TNF, TLR4
5n syndrome10.6
6cocaine abuse10.3
7colonic atresia10.3
8short bowel syndrome10.2
9hypoplastic left heart syndrome10.2
10necrotizing fasciitis10.2
11intestinal atresia10.2
12short syndrome10.2
13zygomycosis10.2
14multiple intestinal atresia10.1
15hemophagocytic lymphohistiocytosis10.1
16digeorge syndrome10.1
17gastroschisis10.1
18omenn syndrome10.1
19portal hypertension10.1
20protein s deficiency10.1
21hyperinsulinism10.1
22capillary leak syndrome10.1
23protein c deficiency10.1
24shigellosis10.1
25biliary hypoplasia10.1
26lipomyelomeningocele10.1
27twin twin transfusion syndrome10.1
28klebsiella10.1
29lactobezoar10.1
30neonatal meningitis10.1
31mitochondrial trifunctional protein deficiency10.1
32protein r deficiency10.1
33trifunctional protein deficiency10.1
34cytomegalovirus infection10.1
35dysautonomia10.1
36hypoxia10.1
37meconium ileus10.1
38ileus10.1
39secondary short bowel syndrome10.1
40neuroendocrine carcinoma10.0
41gastroenteritis10.0TFF3
42stroke, ischemic10.0PLA2G7
43periventricular leukomalacia10.0SERPINH1
44amyloidosis10.0CSN1S1
45ischemia10.0HBEGF
46keratitis10.0TLR4
47celiac disease10.0CSN1S1
48bronchiolitis10.0TLR4
49pyelonephritis10.0TLR4
50sarcoma10.0CSN1S1

Graphical network of the top 20 diseases related to Perinatal Necrotizing Enterocolitis:



Diseases related to perinatal necrotizing enterocolitis

Clinical Features for Perinatal Necrotizing Enterocolitis

Drugs & Therapeutics for Perinatal Necrotizing Enterocolitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Perinatal Necrotizing Enterocolitis

Drug clinical trials:

Search ClinicalTrials for Perinatal Necrotizing Enterocolitis

Search NIH Clinical Center for Perinatal Necrotizing Enterocolitis

Search CenterWatch for Perinatal Necrotizing Enterocolitis

Genetic Tests for Perinatal Necrotizing Enterocolitis

Anatomical Context for Perinatal Necrotizing Enterocolitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Perinatal Necrotizing Enterocolitis:

33
Small intestine

Animal Models for Perinatal Necrotizing Enterocolitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Perinatal Necrotizing Enterocolitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.0IL6, HBEGF, CSN1S1, TLR4
2MP:00053817.8SERPINH1, TLR4, TNF, TFF3, EGF, IL6

Publications for Perinatal Necrotizing Enterocolitis

Genetic Variations for Perinatal Necrotizing Enterocolitis

Expression for genes affiliated with Perinatal Necrotizing Enterocolitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Perinatal Necrotizing Enterocolitis

Search GEO for disease gene expression data for Perinatal Necrotizing Enterocolitis.

Pathways for genes affiliated with Perinatal Necrotizing Enterocolitis

Sources:
30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 53R&D Systems, 52QIAGEN
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Compounds for genes affiliated with Perinatal Necrotizing Enterocolitis

Sources:
45Novoseek, 2BitterDB, 60Tocris Bioscience, 11DrugBank, 29IUPHAR, 50PharmGKB, 24HMDB
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Compounds related to Perinatal Necrotizing Enterocolitis according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1pge24510.7PLA2G7
2estrogen4510.6LTF
3hydrocortisone45 2 60 1113.5LTF
4cycloheximide4510.4PLA2G7, HBEGF
5ivig4510.3PLA2G7
6tocilizumab45 1111.0IL6, TNF
7exorphins4510.0CSN1S1, LTF
8abatacept45 1110.9TNF, IL6
9protamine459.9CSN1S1, LTF
10hcec459.9EGF, HBEGF, IL6
11staurosporin459.8TNF, EGF, HBEGF
12zymosan459.8TLR4, TNF, LTF
13tenidap45 2910.8IL6, LTF, TNF
14imiquimod45 29 60 1112.8IL6, TNF, TLR4
15lipoteichoic acid459.7IL6, TNF, TLR4
16polyinosinic-polycytidylic acid459.7TLR4, TNF, IL6
172,5-oligoadenylate459.7TLR4, TNF, IL6
18poly(i-c)459.7IL6, TNF, TLR4
19il 10459.6IL6, TNF, TLR4
20fenofibrate45 50 1111.6PLA2G7, IL6, TNF
21infliximab45 50 1111.6IL6, TNF, TLR4
22peptidoglycan45 2910.5IL6, TNF, TLR4
23atorvastatin45 50 29 11 2413.5PLA2G7, IL6, TNF, TLR4
24polymyxin b459.5TLR4, TNF, LTF, IL6
25leukotriene b445 60 2411.5PLA2G7, IL6, LTF, TNF
26c2ceramide459.4LTF, TNF, TLR4
27cdp571459.4IL6, TNF
28ccl345 2910.4TLR4, TNF, IL6
29dexamethasone45 50 29 1112.4TLR4, LTF, HBEGF, IL6, PLA2G7
30calcitriol45 60 11 2412.3TLR4, TNF, EGF, IL6
31serine459.3TLR4, CSN1S1, TNF, LTF
32polyacrylamide459.3CSN1S1, LTF, PLA2G7, SERPINH1
33pentoxifylline45 1110.3TNF, LTF, IL6
34endotoxin459.2PLA2G7, IL6, LTF, TNF, TLR4
35tgf beta1459.2TLR4, TNF, EGF, HBEGF, IL6
36n acetylcysteine459.2TLR4, TNF, LTF, HBEGF, IL6
37cyclosporin a45 29 6011.1TLR4, TNF, LTF, IL6, SERPINH1
38histamine45 29 2410.9TLR4, CSN1S1, TNF, LTF, IL6
39pd 98,059458.8TNF, TFF3, EGF, HBEGF, IL6
40indomethacin45 60 29 1111.8TNF, TFF3, EGF, LTF, IL6
41sb 20358045 609.7TLR4, CSN1S1, TNF, EGF, HBEGF, IL6
42ly294002458.7TLR4, CSN1S1, TNF, EGF, HBEGF, IL6
43genistein45 29 60 2 11 2413.7TLR4, CSN1S1, TNF, EGF, HBEGF, IL6
44fibrinogen458.5TLR4, CSN1S1, TNF, LTF, HBEGF, IL6
45nitric oxide45 11 2410.4TLR4, TNF, TFF3, HBEGF, IL6, PLA2G7
46retinoic acid45 249.3TLR4, CSN1S1, TNF, EGF, LTF, HBEGF
47actinomycin d458.3TLR4, TNF, TFF3, EGF, LTF, HBEGF
48cysteine458.2TLR4, CSN1S1, TFF3, EGF, LTF, HBEGF
49h2o2458.1TLR4, CSN1S1, TNF, TFF3, EGF, LTF
50vegf457.5TLR4, TNF, TFF3, EGF, LTF, HBEGF

GO Terms for genes affiliated with Perinatal Necrotizing Enterocolitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Perinatal Necrotizing Enterocolitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.8SERPINH1, IL6, HBEGF, EGF, TNF
2extracellular regionGO:0055767.1PLA2G7, CSN1S1, TNF, TFF3, EGF, LTF

Biological processes related to Perinatal Necrotizing Enterocolitis according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-8 biosynthetic processGO:0454169.9TNF, TLR4
2negative regulation of lipid storageGO:0108889.9IL6, TNF
3epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.8IL6, TNF
4defense response to Gram-negative bacteriumGO:0508299.8IL6, TLR4
5negative regulation of interleukin-6 productionGO:0327159.8TNF, TLR4
6positive regulation of chemokine productionGO:0327229.7IL6, TNF, TLR4
7positive regulation of NF-kappaB import into nucleusGO:0423469.7TNF, TLR4
8positive regulation of smooth muscle cell proliferationGO:0486619.7IL6, HBEGF, TNF
9positive regulation of nitric oxide biosynthetic processGO:0454299.7IL6, TNF, TLR4
10positive regulation of interleukin-6 productionGO:0327559.6TLR4, TNF, IL6
11positive regulation of protein kinase B signaling cascadeGO:0518979.6TNF, HBEGF, IL6
12humoral immune responseGO:0069599.6IL6, LTF, TNF
13positive regulation of ERK1 and ERK2 cascadeGO:0703749.5TLR4, TNF, IL6
14positive regulation of NF-kappaB transcription factor activityGO:0510929.4TLR4, TNF, LTF, IL6
15positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431239.1TLR4, TNF, LTF

Molecular functions related to Perinatal Necrotizing Enterocolitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor receptor bindingGO:0051549.9HBEGF, EGF

Products for genes affiliated with Perinatal Necrotizing Enterocolitis

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  • Lysates
  • Antibodies

Sources for Perinatal Necrotizing Enterocolitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet