NEC
MCID: PRN019
MIFTS: 39

Perinatal Necrotizing Enterocolitis (NEC) malady

Fetal diseases, Gastrointestinal diseases categories

Summaries for Perinatal Necrotizing Enterocolitis

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Necrotizing enterocolitis (nec) is a condition characterized by variable injury or damage to the intestinal tract, causing death of intestinal tissue. the condition most often occurs in premature newborns, but it may also occur in term or near-term babies. signs and symptoms may include abdominal distension, bloody stools, vomiting bile-stained fluid, and pneumatosis intestinalis (gas in the bowel wall) identified on abdominal x-ray. affected infants occasionally have temperature instability, lethargy, or other findings of sepsis. the exact cause of nec is unknown. treatment involves stopping feedings, passing a small tube into the stomach to relieve gas, and giving intravenous fluids and antibiotics. surgery may be needed if there is perforated or necrotic (dead) bowel tissue. about 60-80% of affected newborns survive the condition. last updated: 2/4/2013

MalaCards: Perinatal Necrotizing Enterocolitis, also known as necrotizing enterocolitis, is related to peritonitis and patent ductus arteriosus. An important gene associated with Perinatal Necrotizing Enterocolitis is ZNF213 (zinc finger protein 213), and among its related pathways are Legionellosis and Rheumatoid arthritis. The compounds pge2 and estrogen have been mentioned in the context of this disorder. Related mouse phenotypes are integument and digestive/alimentary.

Aliases & Classifications for Perinatal Necrotizing Enterocolitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 42NIH Rare Diseases, 48Orphanet, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

perinatal necrotizing enterocolitis 8 10
necrotizing enterocolitis 8 42 48
enterocolitis, necrotizing 42 60
enterocolitis necrotizing 8 44
necrotizing enterocolitis in fetus or newborn 8
pseudomembranous enterocolitis in newborn 8
perinatal necrotising enterocolitis 8
nec 42


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Disease Ontology8 DOID:8677
NCIt39 C84915
MeSH34 D020345
ICD1025 P77

Related Diseases for Perinatal Necrotizing Enterocolitis

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17GeneCards, 18GeneDecks
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Diseases related to Perinatal Necrotizing Enterocolitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 147)
idRelated DiseaseScoreTop Affiliating Genes
1peritonitis30.7IL6, TNF
2patent ductus arteriosus30.4OR7E87P, ZNF213
3ischemia30.1HBEGF
4meningitis30.1IL6
5pneumonia30.1TLR4, TNF, IL6, PLA2G7
6inflammatory bowel disease30.0TLR4, TNF, LTF, IL6, PLA2G7
7chorioamnionitis30.0SERPINH1, IL6, LTF, TNF, TLR4
8intestinal perforation10.8
9cocaine abuse10.3
10short bowel syndrome10.2
11hypoplastic left heart syndrome10.2
12necrotizing fasciitis10.2
13intestinal atresia10.2
14fasciitis10.2
15multiple intestinal atresia10.1
16retinopathy of prematurity10.1
17hemophagocytic lymphohistiocytosis10.1
18twin-to-twin transfusion syndrome10.1
19anemia of prematurity10.1
20digeorge syndrome10.1
21gastroschisis10.1
22omenn syndrome10.1
23meckel's diverticulum10.1
24portal hypertension10.1
25hyperinsulinism10.1
26capillary leak syndrome10.1
27shigellosis10.1
28colonic disease10.1
29eosinophilia10.1
30hepatitis10.1
31hypertension10.1
32intestinal disease10.1
33pertussis10.1
34neuroendocrine carcinoma10.0
35bronchopulmonary dysplasia10.0PLA2G7
36gastroenteritis10.0TFF3
37stroke, ischemic10.0PLA2G7
38periventricular leukomalacia10.0SERPINH1
39amyloidosis10.0CSN1S1
40keratitis10.0TLR4
41celiac disease10.0CSN1S1
42bronchiolitis10.0TLR4
43pyelonephritis10.0TLR4
44sarcoma10.0CSN1S1
45hepatic encephalopathy10.0CSN1S1
46cervical incompetence10.0SERPINH1
47gastroesophageal reflux disease10.0CSN1S1
48gingivitis10.0LTF
49multiple system atrophy10.0KIAA0101
50otitis media10.0LTF

Graphical network of the top 20 diseases related to Perinatal Necrotizing Enterocolitis:



Diseases related to perinatal necrotizing enterocolitis

Clinical Features for Perinatal Necrotizing Enterocolitis

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Drugs & Therapeutics for Perinatal Necrotizing Enterocolitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Perinatal Necrotizing Enterocolitis

Search NIH Clinical Center for Perinatal Necrotizing Enterocolitis

Search CenterWatch for Perinatal Necrotizing Enterocolitis

Genetic Tests for Perinatal Necrotizing Enterocolitis

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Anatomical Context for Perinatal Necrotizing Enterocolitis

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Animal Models for Perinatal Necrotizing Enterocolitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Perinatal Necrotizing Enterocolitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.0IL6, HBEGF, CSN1S1, TLR4
2MP:00053817.8SERPINH1, TLR4, TNF, TFF3, EGF, IL6

Publications for Perinatal Necrotizing Enterocolitis

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Genetic Variations for Perinatal Necrotizing Enterocolitis

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Expression for genes affiliated with Perinatal Necrotizing Enterocolitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Perinatal Necrotizing Enterocolitis

Search GEO for disease gene expression data for Perinatal Necrotizing Enterocolitis.

Pathways for genes affiliated with Perinatal Necrotizing Enterocolitis

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Sources:
29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems, 51QIAGEN
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Compounds for genes affiliated with Perinatal Necrotizing Enterocolitis

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Sources:
44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Perinatal Necrotizing Enterocolitis according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1pge24410.7PLA2G7
2estrogen4410.6LTF
3hydrocortisone44 2 59 1113.5LTF
4cycloheximide4410.4HBEGF, PLA2G7
5ivig4410.3PLA2G7
6tocilizumab44 1111.0IL6, TNF
7exorphins4410.0LTF, CSN1S1
8abatacept44 1110.9IL6, TNF
9protamine449.9LTF, CSN1S1
10hcec449.9EGF, IL6, HBEGF
11staurosporin449.8HBEGF, TNF, EGF
12zymosan449.8TNF, LTF, TLR4
13tenidap44 2810.8LTF, TNF, IL6
14imiquimod44 28 59 1112.8TLR4, IL6, TNF
15lipoteichoic acid449.7TLR4, TNF, IL6
16polyinosinic-polycytidylic acid449.7TLR4, IL6, TNF
172,5-oligoadenylate449.7IL6, TNF, TLR4
18poly(i-c)449.7IL6, TNF, TLR4
19il 10449.6TNF, IL6, TLR4
20fenofibrate44 49 1111.6TNF, PLA2G7, IL6
21infliximab44 49 1111.6IL6, TNF, TLR4
22peptidoglycan44 2810.5TNF, IL6, TLR4
23atorvastatin44 49 28 11 2413.5TLR4, TNF, IL6, PLA2G7
24polymyxin b449.5IL6, TNF, TLR4, LTF
25leukotriene b444 59 2411.5PLA2G7, IL6, TNF, LTF
26c2ceramide449.4TNF, TLR4, LTF
27cdp571449.4TNF, IL6
28dexamethasone44 49 28 1112.4HBEGF, PLA2G7, TLR4, LTF, IL6
29pentoxifylline44 1110.4IL6, TNF, LTF
30calcitriol44 59 11 2412.3EGF, IL6, TNF, TLR4
31serine449.3TNF, LTF, TLR4, CSN1S1
32ccl344 2810.3IL6, TLR4, TNF
33polyacrylamide449.3PLA2G7, CSN1S1, LTF, SERPINH1
34endotoxin449.2PLA2G7, IL6, LTF, TNF, TLR4
35tgf beta1449.2EGF, TLR4, TNF, IL6, HBEGF
36n acetylcysteine449.2TLR4, TNF, LTF, HBEGF, IL6
37cyclosporin a44 28 5911.1TLR4, TNF, LTF, IL6, SERPINH1
38histamine44 28 2410.9TLR4, IL6, LTF, TNF, CSN1S1
39pd 98,059448.8HBEGF, TNF, TFF3, IL6, EGF
40indomethacin44 59 28 1111.8TFF3, LTF, IL6, TNF, EGF
41sb 20358044 599.7CSN1S1, TLR4, TNF, HBEGF, IL6, EGF
42ly294002448.7CSN1S1, TLR4, IL6, EGF, HBEGF, TNF
43genistein44 28 59 2 11 2413.7CSN1S1, TLR4, TNF, EGF, HBEGF, IL6
44fibrinogen448.5PLA2G7, IL6, HBEGF, TNF, CSN1S1, TLR4
45nitric oxide44 11 2410.4TLR4, SERPINH1, TNF, PLA2G7, IL6, HBEGF
46retinoic acid44 249.3HBEGF, LTF, EGF, TNF, CSN1S1, IL6
47actinomycin d448.3TLR4, TNF, EGF, LTF, HBEGF, IL6
48cysteine448.2LTF, HBEGF, EGF, TFF3, TLR4, CSN1S1
49h2o2448.1TNF, TFF3, EGF, LTF, HBEGF, TLR4
50vegf447.5IL6, LTF, HBEGF, CLDN3, TFF3, TNF

GO Terms for genes affiliated with Perinatal Necrotizing Enterocolitis

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Sources:
16Gene Ontology
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Cellular components related to Perinatal Necrotizing Enterocolitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.8SERPINH1, IL6, HBEGF, EGF, TNF
2extracellular regionGO:0055767.1PLA2G7, CSN1S1, TNF, TFF3, EGF, LTF

Biological processes related to Perinatal Necrotizing Enterocolitis according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-8 biosynthetic processGO:0454169.9TNF, TLR4
2negative regulation of lipid storageGO:0108889.9IL6, TNF
3epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.8IL6, TNF
4defense response to Gram-negative bacteriumGO:0508299.8IL6, TLR4
5negative regulation of interleukin-6 productionGO:0327159.8TNF, TLR4
6positive regulation of chemokine productionGO:0327229.7IL6, TNF, TLR4
7positive regulation of NF-kappaB import into nucleusGO:0423469.7TNF, TLR4
8positive regulation of smooth muscle cell proliferationGO:0486619.7IL6, HBEGF, TNF
9positive regulation of nitric oxide biosynthetic processGO:0454299.7IL6, TNF, TLR4
10positive regulation of interleukin-6 productionGO:0327559.6TLR4, TNF, IL6
11positive regulation of protein kinase B signaling cascadeGO:0518979.6TNF, HBEGF, IL6
12humoral immune responseGO:0069599.6IL6, LTF, TNF
13positive regulation of ERK1 and ERK2 cascadeGO:0703749.5TLR4, TNF, IL6
14positive regulation of NF-kappaB transcription factor activityGO:0510929.4TLR4, TNF, LTF, IL6
15positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431239.1TLR4, TNF, LTF

Molecular functions related to Perinatal Necrotizing Enterocolitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor receptor bindingGO:0051549.9HBEGF, EGF

Products for genes affiliated with Perinatal Necrotizing Enterocolitis

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  • Antibodies
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Sources for Perinatal Necrotizing Enterocolitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet