NEC
MCID: PRN019
MIFTS: 36

Perinatal Necrotizing Enterocolitis (NEC) malady

Rare diseases, Fetal diseases, Gastrointestinal diseases categories
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Summaries for Perinatal Necrotizing Enterocolitis

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NIH Rare Diseases:42 Necrotizing enterocolitis (nec) is a condition characterized by variable injury or damage to the intestinal tract, causing death of intestinal tissue. the condition most often occurs in premature newborns, but it may also occur in term or near-term babies. signs and symptoms may include abdominal distension, bloody stools, vomiting bile-stained fluid, and pneumatosis intestinalis (gas in the bowel wall) identified on abdominal x-ray. affected infants occasionally have temperature instability, lethargy, or other findings of sepsis. the exact cause of nec is unknown. treatment involves stopping feedings, passing a small tube into the stomach to relieve gas, and giving intravenous fluids and antibiotics. surgery may be needed if there is perforated or necrotic (dead) bowel tissue. about 60-80% of affected newborns survive the condition. last updated: 2/4/2013

MalaCards based summary: Perinatal Necrotizing Enterocolitis, also known as necrotizing enterocolitis, is related to sepsis and chorioamnionitis. An important gene associated with Perinatal Necrotizing Enterocolitis is HBEGF (heparin-binding EGF-like growth factor), and among its related pathways are Proteoglycans in cancer and Development Slit Robo signaling. The compounds tgf beta1 and chlorate have been mentioned in the context of this disorder. Related mouse phenotypes are skeleton and respiratory system.

Aliases & Classifications for Perinatal Necrotizing Enterocolitis

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Sources:
8Disease Ontology, 10DISEASES, 62UMLS, 42NIH Rare Diseases, 48Orphanet, 44Novoseek, 57SNOMED-CT, 34MeSH, 39NCIt, 26ICD10 via Orphanet, 25ICD10
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Perinatal Necrotizing Enterocolitis, Aliases & Descriptions:

Name: Perinatal Necrotizing Enterocolitis 8 10
Necrotizing Enterocolitis 8 42 48
Pseudomembranous Enterocolitis in Newborn 8 62
Perinatal Necrotising Enterocolitis 8 62
 
Enterocolitis, Necrotizing 42 62
Enterocolitis Necrotizing 8 44
Nec 42 62
Necrotizing Enterocolitis in Fetus or Newborn 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Fetal diseases
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology8 DOID:8677
MeSH34 D020345
NCIt39 C84915
ICD10 via Orphanet26 P77
ICD1025 P77

Related Diseases for Perinatal Necrotizing Enterocolitis

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Graphical network of the top 20 diseases related to Perinatal Necrotizing Enterocolitis:



Diseases related to perinatal necrotizing enterocolitis

Symptoms for Perinatal Necrotizing Enterocolitis

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Drugs & Therapeutics for Perinatal Necrotizing Enterocolitis

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Drug clinical trials:

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Search NIH Clinical Center for Perinatal Necrotizing Enterocolitis

Genetic Tests for Perinatal Necrotizing Enterocolitis

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Anatomical Context for Perinatal Necrotizing Enterocolitis

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Animal Models for Perinatal Necrotizing Enterocolitis or affiliated genes

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MGI Mouse Phenotypes related to Perinatal Necrotizing Enterocolitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.8SERPINH1, HBEGF, TLR4
2MP:00053888.5SERPINH1, HBEGF, TLR4

Publications for Perinatal Necrotizing Enterocolitis

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Variations for Perinatal Necrotizing Enterocolitis

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Expression for genes affiliated with Perinatal Necrotizing Enterocolitis

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Expression patterns in normal tissues for genes affiliated with Perinatal Necrotizing Enterocolitis

Search GEO for disease gene expression data for Perinatal Necrotizing Enterocolitis.

Pathways for genes affiliated with Perinatal Necrotizing Enterocolitis

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Pathways related to Perinatal Necrotizing Enterocolitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4HBEGF, TLR4
2
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion60
Pathogenic Escherichia coli infection37
9.4HBEGF, TLR4

Compounds for genes affiliated with Perinatal Necrotizing Enterocolitis

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Compounds related to Perinatal Necrotizing Enterocolitis according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1tgf beta1449.7HBEGF, TLR4
2chlorate449.5LTF, HBEGF
3pneumococcal449.5LTF, TLR4
4zymosan449.5TLR4, LTF
5polymyxin b449.5TLR4, LTF
6anti-fungal449.5LTF, TLR4
7c2ceramide449.5LTF, TLR4
8chondroitin sulfate44 2410.5HBEGF, LTF
9sb 20358044 6110.4HBEGF, TLR4
10carbohydrates449.4LTF, TLR4
11mannose449.4TLR4, LTF
12heparan sulfate44 2410.4LTF, HBEGF
13endotoxin449.4LTF, TLR4
14fmlp449.3TLR4, LTF
15nacl449.3LTF, HBEGF
16vitamin a44 24 1111.3LTF, HBEGF
17nitric oxide44 24 1111.1SERPINH1, HBEGF, TLR4
18polyacrylamide449.1SERPINH1, LTF
19phospholipid449.1HBEGF, TLR4
20histamine44 28 2411.1LTF, TLR4
21atp44 2810.1SERPINH1, HBEGF, TLR4
22ascorbic acid44 2410.1LTF, SERPINH1
23latex449.0LTF, HBEGF, TLR4
24n acetylcysteine449.0TLR4, HBEGF, LTF
25polysaccharide449.0LTF, HBEGF, TLR4
26fibrinogen449.0LTF, HBEGF, TLR4
27actinomycin d449.0LTF, HBEGF, TLR4
28pge2449.0LTF, HBEGF, TLR4
29h2o2449.0TLR4, HBEGF, LTF
30dexamethasone44 50 28 1112.0TLR4, HBEGF, LTF
31alanine448.9LTF, HBEGF, TLR4
32retinoic acid44 249.9TLR4, HBEGF, LTF
33cysteine448.9TLR4, HBEGF, LTF
34cyclosporin a44 28 6110.9LTF, SERPINH1, TLR4
35tyrosine448.7TLR4, HBEGF, SERPINH1
36vegf448.4TLR4, HBEGF, SERPINH1, LTF
37serine448.4TLR4, HBEGF, SERPINH1, LTF

GO Terms for genes affiliated with Perinatal Necrotizing Enterocolitis

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Cellular components related to Perinatal Necrotizing Enterocolitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5LTF, SERPINH1, HBEGF

Biological processes related to Perinatal Necrotizing Enterocolitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.1LTF, TLR4
2positive regulation of NF-kappaB transcription factor activityGO:0510928.8LTF, TLR4

Molecular functions related to Perinatal Necrotizing Enterocolitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082019.1LTF, HBEGF

Products for genes affiliated with Perinatal Necrotizing Enterocolitis

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  • Antibodies
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Sources for Perinatal Necrotizing Enterocolitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet