NEC
MCID: PRN019
MIFTS: 35

Perinatal Necrotizing Enterocolitis (NEC) malady

Rare diseases, Fetal diseases, Gastrointestinal diseases categories
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Summaries for Perinatal Necrotizing Enterocolitis

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43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Necrotizing enterocolitis (nec) is a condition characterized by variable injury or damage to the intestinal tract, causing death of intestinal tissue. the condition most often occurs in premature newborns, but it may also occur in term or near-term babies. signs and symptoms may include abdominal distension, bloody stools, vomiting bile-stained fluid, and pneumatosis intestinalis (gas in the bowel wall) identified on abdominal x-ray. affected infants occasionally have temperature instability, lethargy, or other findings of sepsis. the exact cause of nec is unknown. treatment involves stopping feedings, passing a small tube into the stomach to relieve gas, and giving intravenous fluids and antibiotics. surgery may be needed if there is perforated or necrotic (dead) bowel tissue. about 60-80% of affected newborns survive the condition. last updated: 2/4/2013

MalaCards: Perinatal Necrotizing Enterocolitis, also known as necrotizing enterocolitis, is related to sepsis and inflammatory bowel disease. An important gene associated with Perinatal Necrotizing Enterocolitis is HBEGF (heparin-binding EGF-like growth factor), and among its related pathways are Proteoglycans in cancer and Development Slit Robo signaling. The compounds tgf beta1 and chlorate have been mentioned in the context of this disorder. Related mouse phenotypes are skeleton and respiratory system.

Aliases & Classifications for Perinatal Necrotizing Enterocolitis

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8Disease Ontology, 10DISEASES, 45Novoseek, 43NIH Rare Diseases, 49Orphanet, 62UMLS, 35MeSH, 40NCIt, 58SNOMED-CT, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Fetal diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

perinatal necrotizing enterocolitis 8 10
necrotizing enterocolitis 8 43 49
enterocolitis, necrotizing 43 62
enterocolitis necrotizing 8 45
necrotizing enterocolitis in fetus or newborn 8
pseudomembranous enterocolitis in newborn 8
perinatal necrotising enterocolitis 8
nec 43


External Ids:

Disease Ontology8 DOID:8677
MeSH35 D020345
NCIt40 C84915
ICD10 via Orphanet26 P77
ICD1025 P77

Related Diseases for Perinatal Necrotizing Enterocolitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Perinatal Necrotizing Enterocolitis:



Diseases related to perinatal necrotizing enterocolitis

Symptoms for Perinatal Necrotizing Enterocolitis

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Drugs & Therapeutics for Perinatal Necrotizing Enterocolitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Perinatal Necrotizing Enterocolitis

Search NIH Clinical Center for Perinatal Necrotizing Enterocolitis

Genetic Tests for Perinatal Necrotizing Enterocolitis

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Anatomical Context for Perinatal Necrotizing Enterocolitis

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Animal Models for Perinatal Necrotizing Enterocolitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Perinatal Necrotizing Enterocolitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.8SERPINH1, HBEGF, TLR4
2MP:00053888.5SERPINH1, HBEGF, TLR4

Publications for Perinatal Necrotizing Enterocolitis

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Variations for Perinatal Necrotizing Enterocolitis

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Expression for genes affiliated with Perinatal Necrotizing Enterocolitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Perinatal Necrotizing Enterocolitis

Search GEO for disease gene expression data for Perinatal Necrotizing Enterocolitis.

Pathways for genes affiliated with Perinatal Necrotizing Enterocolitis

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Sources:
50PathCards, 30KEGG, 60Thomson Reuters, 38NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Perinatal Necrotizing Enterocolitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4HBEGF, TLR4
2
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion60
Pathogenic Escherichia coli infection38
9.4HBEGF, TLR4

Compounds for genes affiliated with Perinatal Necrotizing Enterocolitis

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45Novoseek, 24HMDB, 61Tocris Bioscience, 11DrugBank, 29IUPHAR, 51PharmGKB
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Compounds related to Perinatal Necrotizing Enterocolitis according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1tgf beta1459.7HBEGF, TLR4
2chlorate459.5LTF, HBEGF
3pneumococcal459.5LTF, TLR4
4zymosan459.5TLR4, LTF
5polymyxin b459.5TLR4, LTF
6anti-fungal459.5LTF, TLR4
7c2ceramide459.5LTF, TLR4
8chondroitin sulfate45 2410.5HBEGF, LTF
9sb 20358045 6110.4HBEGF, TLR4
10carbohydrates459.4LTF, TLR4
11mannose459.4TLR4, LTF
12heparan sulfate45 2410.4LTF, HBEGF
13endotoxin459.4LTF, TLR4
14fmlp459.3TLR4, LTF
15nacl459.3LTF, HBEGF
16vitamin a45 24 1111.3LTF, HBEGF
17nitric oxide45 24 1111.1SERPINH1, HBEGF, TLR4
18polyacrylamide459.1SERPINH1, LTF
19phospholipid459.1HBEGF, TLR4
20histamine45 29 2411.1LTF, TLR4
21atp45 2910.1SERPINH1, HBEGF, TLR4
22ascorbic acid45 2410.1LTF, SERPINH1
23latex459.0LTF, HBEGF, TLR4
24n acetylcysteine459.0TLR4, HBEGF, LTF
25polysaccharide459.0LTF, HBEGF, TLR4
26fibrinogen459.0LTF, HBEGF, TLR4
27actinomycin d459.0LTF, HBEGF, TLR4
28pge2459.0LTF, HBEGF, TLR4
29h2o2459.0TLR4, HBEGF, LTF
30dexamethasone45 51 29 1112.0TLR4, HBEGF, LTF
31alanine458.9LTF, HBEGF, TLR4
32retinoic acid45 249.9TLR4, HBEGF, LTF
33cysteine458.9TLR4, HBEGF, LTF
34cyclosporin a45 29 6110.9LTF, SERPINH1, TLR4
35tyrosine458.7TLR4, HBEGF, SERPINH1
36vegf458.4TLR4, HBEGF, SERPINH1, LTF
37serine458.4TLR4, HBEGF, SERPINH1, LTF

GO Terms for genes affiliated with Perinatal Necrotizing Enterocolitis

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16Gene Ontology
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Cellular components related to Perinatal Necrotizing Enterocolitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5LTF, SERPINH1, HBEGF

Biological processes related to Perinatal Necrotizing Enterocolitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.1LTF, TLR4
2positive regulation of NF-kappaB transcription factor activityGO:0510928.8LTF, TLR4

Molecular functions related to Perinatal Necrotizing Enterocolitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082019.1LTF, HBEGF

Products for genes affiliated with Perinatal Necrotizing Enterocolitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Perinatal Necrotizing Enterocolitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet