MCID: PRN019
MIFTS: 45

Perinatal Necrotizing Enterocolitis

Categories: Rare diseases, Fetal diseases, Gastrointestinal diseases

Aliases & Classifications for Perinatal Necrotizing Enterocolitis

MalaCards integrated aliases for Perinatal Necrotizing Enterocolitis:

Name: Perinatal Necrotizing Enterocolitis 12 14
Necrotizing Enterocolitis 12 50 56 69
Enterocolitis, Necrotizing 50 42
Enterocolitis Necrotizing 12 52
Necrotizing Enterocolitis in Fetus or Newborn 12
Pseudomembranous Enterocolitis in Newborn 12
Perinatal Necrotising Enterocolitis 12
Nec 50

Characteristics:

Orphanet epidemiological data:

56
necrotizing enterocolitis
Prevalence: 1-5/10000 (Worldwide); Age of onset: Neonatal; Age of death: infantile;

Classifications:



External Ids:

Disease Ontology 12 DOID:8677
MeSH 42 D020345
NCIt 47 C84915
Orphanet 56 ORPHA391673
UMLS via Orphanet 70 C0520459
ICD10 via Orphanet 34 P77
ICD10 33 P77
UMLS 69 C0520459

Summaries for Perinatal Necrotizing Enterocolitis

NIH Rare Diseases : 50 necrotizing enterocolitis (nec) is a condition characterized by variable injury or damage to the intestinal tract, causing death of intestinal tissue. the condition most often occurs in premature newborns, but it may also occur in term or near-term babies. signs and symptoms may include abdominal distension, bloody stools, vomiting bile-stained fluid, and pneumatosis intestinalis (gas in the bowel wall) identified on abdominal x-ray. affected infants occasionally have temperature instability, lethargy, or other findings of sepsis. the exact cause of nec is unknown. treatment involves stopping feedings, passing a small tube into the stomach to relieve gas, and giving intravenous fluids and antibiotics. surgery may be needed if there is perforated or necrotic (dead) bowel tissue. about 60-80% of affected newborns survive the condition. last updated: 2/4/2013

MalaCards based summary : Perinatal Necrotizing Enterocolitis, also known as necrotizing enterocolitis, is related to capillary leak syndrome and short bowel syndrome. An important gene associated with Perinatal Necrotizing Enterocolitis is FABP2 (Fatty Acid Binding Protein 2), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Poractant alfa and Indomethacin have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and colon, and related phenotypes are digestive/alimentary and immune system

Wikipedia : 72 Necrotizing enterocolitis (NEC) is a medical condition primarily seen in premature infants, where... more...

Related Diseases for Perinatal Necrotizing Enterocolitis

Diseases related to Perinatal Necrotizing Enterocolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 298)
id Related Disease Score Top Affiliating Genes
1 capillary leak syndrome 29.3 CRP CXCL8
2 short bowel syndrome 11.3
3 peroneal nerve paralysis 10.6 IL6 TLR9
4 prothrombin thrombophilia 10.4 IL1B TLR4
5 gonococcal keratitis 10.4 IL6 SERPINH1
6 intestinal perforation 10.4
7 spondylocostal dysostosis 4 10.4 TLR4 TNF
8 congenital insensitivity to pain with hyperhidrosis 10.4 CXCL8 TLR4
9 smarca4-deficient sarcoma of thorax 10.4 IL6 TNF
10 rickettsialpox 10.4 TLR4 TNF
11 aortic arch interruption 10.3 IL6 TNF
12 low compliance bladder 10.3 TLR4 TNF
13 drug rash with eosinophilia and systemic symptoms 10.3 CXCL8 IL6
14 cutaneous leishmaniasis 10.3 IL6 TNF
15 tinea barbae 10.3 CXCL8 TLR4 TLR9
16 basidiobolomycosis 10.3 CXCL8 TNF
17 villous adenoma 10.3 CXCL8 EGF TLR9
18 tracheal calcification 10.3 TLR9 TNF
19 toxoplasmosis 10.2 IL6 TNF
20 tabatznik syndrome 10.2 IL1B TNF
21 sternal cleft 10.2 IL1B TNF
22 lateral cystocele 10.2 CXCL8 IL6 TLR4
23 dengue disease 10.2 TLR4 TLR9 TNF
24 pulmonary hypertension 10.2 IL1B TNF
25 dyslexia 5 10.2 IL6 TNF
26 antigen-peptide-transporter 2 deficiency 10.2 IL6 TLR4 TNF
27 osteogenesis imperfecta, type x 10.2 CXCL8 IL6 SERPINH1
28 syphilitic encephalitis 10.1 IL1B IL6 TLR4
29 thymus lymphoma 10.1 EGF IL6 TNF
30 heart sarcoma 10.1 IL6 TLR9 TNF
31 acute interstitial pneumonia 10.1 IL6 TLR9 TNF
32 abnormal retinal correspondence 10.1 IL6 TLR4 TNF
33 melioidosis 10.1 IL6 TLR4 TNF
34 dehydration polycythemia 10.1 CXCL8 TLR9 TNF
35 fibrosarcomatous osteosarcoma 10.1 CXCL8 IL1B TLR9
36 pelvic varices 10.1 CXCL8 TLR9 TNF
37 walker dyson syndrome 10.1 IL1B TNF
38 gallbladder cancer 10.1 IL6 TLR9 TNF
39 fuchs' heterochromic uveitis 10.1 CXCL8 TLR9 TNF
40 collagenopathy type 2 alpha 1 10.1 CRP IL6
41 schwannoma of ureter 10.1 CXCL8 IL6
42 uterine corpus dissecting leiomyoma 10.1 CXCL8 EGF HBEGF IL6
43 oculomotor nerve paralysis 10.0 CXCL8 IL1B IL6
44 common peroneal nerve lesion 10.0 CXCL8 IL1B IL6
45 crystal arthropathies 10.0 CRP IL6
46 peritonitis 10.0
47 spirillary rat-bite fever 10.0 CXCL8 IL6 TNF
48 shoulder impingement syndrome 10.0 CRP IL6
49 pasteurellosis 10.0 CXCL8 IL6 TNF
50 bartonellosis 10.0 IL1B TLR4 TNF

Graphical network of the top 20 diseases related to Perinatal Necrotizing Enterocolitis:



Diseases related to Perinatal Necrotizing Enterocolitis

Symptoms & Phenotypes for Perinatal Necrotizing Enterocolitis

MGI Mouse Phenotypes related to Perinatal Necrotizing Enterocolitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.5 TLR4 TLR9 TNF EGF IL6 SERPINH1
2 immune system MP:0005387 9.32 CRP EGF IL1B IL6 PLA2G7 SIGIRR

Drugs & Therapeutics for Perinatal Necrotizing Enterocolitis

Drugs for Perinatal Necrotizing Enterocolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 223)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Poractant alfa Approved Phase 4 129069-19-8
2
Indomethacin Approved, Investigational Phase 4,Phase 3,Phase 2 53-86-1 3715
3
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3 22916-47-8 4189
4
Nystatin Approved, Vet_approved Phase 4 1400-61-9 11953884
5
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1 15687-27-1 3672
6
Progesterone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 57-83-0 5994
7
Caffeine Approved, Nutraceutical Phase 4,Phase 3 58-08-2 2519
8
Iodine Investigational Phase 4 7553-56-2 807
9 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
10 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
11 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
12 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1
13 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
14 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
15 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
16 Calcium, Dietary Phase 4,Phase 3,Phase 2
17 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2
18 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
19 Hormones Phase 4,Phase 2,Phase 3,Phase 1
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
21 Pulmonary Surfactants Phase 4,Phase 3,Phase 2
22 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1
23 Tocolytic Agents Phase 4,Phase 3,Phase 2
24 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
25 Lactoferrin Phase 4
26 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Phase 2
27 Antifungal Agents Phase 4,Phase 3
28 Ionophores Phase 4
29 Anticoagulants Phase 4,Phase 3
30 Caffeine citrate Phase 4,Phase 3
31 Central Nervous System Stimulants Phase 4,Phase 3
32 Chelating Agents Phase 4,Phase 3
33 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
34 Purinergic P1 Receptor Antagonists Phase 4,Phase 3
35 11-hydroxyprogesterone Phase 4,Phase 2,Phase 3,Phase 1
36 17-alpha-hydroxy-progesterone caproate Phase 4,Phase 2,Phase 3,Phase 1
37 Estrogen Antagonists Phase 4,Phase 2,Phase 3,Phase 1
38 Estrogens Phase 4,Phase 2,Phase 3,Phase 1
39 Progestins Phase 4,Phase 2,Phase 3,Phase 1
40 Anti-Infective Agents, Local Phase 4
41 cadexomer iodine Phase 4
42 Micronutrients Phase 4,Phase 3,Phase 2
43 Trace Elements Phase 4,Phase 3,Phase 2
44 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 1,Phase 2
45 Antitubercular Agents Phase 4,Phase 3,Phase 2
46 Acidophilus Nutraceutical Phase 4,Phase 3,Phase 2
47 Bifidobacterium Nutraceutical Phase 4,Phase 3,Phase 2
48 Citrate Nutraceutical Phase 4,Phase 3,Phase 2
49
Citric Acid Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 77-92-9 311
50 Caproate Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 315)

id Name Status NCT ID Phase Drugs
1 Withholding Feeds During Red Blood Cell Transfusion and TRAGI Unknown status NCT02132819 Phase 4
2 The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) Unknown status NCT01765998 Phase 4 Probiotic;Placebo
3 Cpap at Delivery Room for Preterm Infants Unknown status NCT01024361 Phase 4
4 Intragastric and Peritoneal Microdialysis in Infants With Necrotizing Enterocolitis (NEC) Completed NCT00332592 Phase 4
5 Probiotics to Prevent NEC - a Historical Control Study Completed NCT01670916 Phase 4
6 Early Versus Late Lactoferrin in Prevention of Neonatal Sepsis Completed NCT02959229 Phase 4 Lactoferrin;Placebo (for Lactoferrin)
7 Comparison of Lactobacillus Reuteri and Nystatin Prophylaxis on Candida Colonization and Infection in Very Low Birth Weight Infants Completed NCT01531192 Phase 4 Nystatin
8 Ibuprofen and Renal Function in Premature Infants Completed NCT00217191 Phase 4 Ibuprofen
9 MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine Completed NCT00809055 Phase 4 Caffeine citrate
10 Efficacy of 17 Alpha-hydroxyprogesterones Caproate for the Prevention of Preterm Delivery Completed NCT00331695 Phase 4 17 alpha-hydroxyprogesterones caproate
11 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV Completed NCT01604447 Phase 4
12 Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates Completed NCT01403623 Phase 4
13 A Randomised Controlled Trial of Iodide Supplementation in Preterm Infants Follow-up at 2 Years Completed NCT00638092 Phase 4 sodium iodide;Sodium Chloride
14 Impact of Oral Application of Gastrografin on the Meconium Evacuation in Very Low Birth Weight Infants Completed NCT01515696 Phase 4 Gastrografin;Sterile water
15 Pilot Study to Compare Fresh Frozen Plasma With 24-Hour Plasma in Babies Up to Age Six Months Recruiting NCT02774317 Phase 4
16 OPTIMIST-A Trial: Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on CPAP Recruiting NCT02140580 Phase 4
17 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part II Recruiting NCT01604421 Phase 4
18 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part I Recruiting NCT01604317 Phase 4
19 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part III Recruiting NCT01604434 Phase 4
20 Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM) Terminated NCT00201656 Phase 4
21 Sodium Supplementation and Growth in Very Low Birth Weight Infants Terminated NCT01795638 Phase 4 Sodium chloride;Placebo
22 RCT of Postoperative Infections Following Caesarean Section Infections Following Caesarean Section Withdrawn NCT02009098 Phase 4 Cefuroxime
23 Comparing Ibuprofen And Indomethacin For The Treatment Of The Patent Ductus Arteriosus in Very Premature Babies Withdrawn NCT00470743 Phase 4 Ibuprofen;Indomethacin
24 Effect of Saccharomyces Boulardii on Necrotizing Enterocolitis in Very Low Birth Weight Infants Unknown status NCT01315821 Phase 3 Saccharomyces boulardii;Placebo
25 Randomized Study of Pessary Versus Standard Management in Women With Increased Chance of Premature Birth Unknown status NCT00735137 Phase 3
26 Cysteine Supplementation in Critically Ill Neonates Unknown status NCT00254176 Phase 2, Phase 3
27 Efficacy Study of Hypothermia Plus Magnesium Sulphate(MgSO4) in the Management of Term and Near Term Babies With Hypoxic Ischemic Encephalopathy Unknown status NCT01646619 Phase 3 Magnesium Sulphate;Placebo
28 Lactobacillus Reuteri for Prevention of Necrotizing Enterocolitis in Very Low-birth Weight Infants Completed NCT01531179 Phase 3 Lactobacillus reuteri;Placebo
29 Probiotics in the Management of Necrotizing Enterocolitis in HIV-exposed Premature Infants Completed NCT01868737 Phase 3
30 The Efficacy of Symbiotic on Cytokines Completed NCT01899677 Phase 3 symbiotic
31 Effect of Oral Probiotic Supplementation on The Rate of Hospital Acquired Infection and Necrotizing Enterocolitis in Preterm Very Low Birth Weight Infants Completed NCT01340469 Phase 3
32 Role of Probiotics for Prevention of NEC in Preterm VLBW Infants Completed NCT02650869 Phase 3
33 Effect of Vitamin A in the Treatment of Neonatal Sepsis and Necrotizing Enterocolitis Completed NCT00707785 Phase 3
34 A Single Blinded Study on the Effect of Saccharomyces Boulardii CNCM I-745 on Growth and Development in Preterm Infants Completed NCT02310425 Phase 3 S. boulardii;Placebo
35 Prevention Trial of Nosocomial Infections in Neutropenic Prematures With G-CSF Completed NCT00213759 Phase 3 filgrastim;dextrose 5%
36 Progesterone Vaginal Pessary for Prevention of Preterm Twin Birth Completed NCT02350231 Phase 2, Phase 3 The progesterone vaginal pessary;Tonics group
37 Ursodiol for Treating Parenteral Nutrition Associated Cholestasis in Neonates Completed NCT00846963 Phase 2, Phase 3 Ursodiol;placebo
38 Trial of Indomethacin Prophylaxis in Preterm Infants (TIPP) Completed NCT00009646 Phase 3 indomethacin;Indomethacin;Placebo
39 Intravenous Immunoglobulin in Prevention of Preterm Neonatal Sepsis Completed NCT02954926 Phase 3 IVIG
40 PREGNANT Short Cervix Trial Completed NCT00615550 Phase 3 progesterone;placebo
41 A Trial Evaluating the Role of Sildenafil in the Treatment of Fetal Growth Restriction Completed NCT02590536 Phase 3 Sildenafil citrate;placebo
42 Intravenous Immune Globulin (IVIG) to Prevent Neonatal Infection Completed NCT01203345 Phase 2, Phase 3 IVIG;Placebo
43 17OHP for Reduction of Neonatal Morbidity Due to Preterm Birth (PTB) in Twin and Triplet Pregnancies Completed NCT00163020 Phase 2, Phase 3 17-alpha-hydroxyprogesterone caproate injectable;Placebo
44 Caffeine for Apnea of Prematurity (CAP) Completed NCT00182312 Phase 3 Caffeine citrate injection
45 NIV Strategies for RDS in Preterm Infants. NIV (Non Invasive Ventilation), RDS (Respiratory Distress Syndrome) Completed NCT02259400 Phase 2, Phase 3
46 Surfactant Positive Airway Pressure and Pulse Oximetry Trial Completed NCT00233324 Phase 3 Surfactant;Supplemental oxygen with target saturation of 85 to 89%;Supplemental oxygen with target saturation of 91 to 95%
47 Fluconazole Prophylaxis for the Prevention of Candidiasis in Infants Less Than 750 Grams Birthweight Completed NCT00734539 Phase 3 fluconazole;placebo
48 Glutamine Supplementation to Prevent Death or Infection in Extremely Premature Infants Completed NCT00005775 Phase 3 Glutamine;Placebo
49 High Dose Folic Acid Supplementation Throughout Pregnancy for Preeclampsia Prevention Completed NCT01355159 Phase 3 Folic Acid 4 mg;Placebo
50 Pentoxifylline and Late Onset Sepsis in Preterm Infants Completed NCT02163174 Phase 3 Pentoxifylline (PTX);Placebo

Search NIH Clinical Center for Perinatal Necrotizing Enterocolitis

Cochrane evidence based reviews: enterocolitis, necrotizing

Genetic Tests for Perinatal Necrotizing Enterocolitis

Anatomical Context for Perinatal Necrotizing Enterocolitis

MalaCards organs/tissues related to Perinatal Necrotizing Enterocolitis:

39
Heart, Brain, Colon, Neutrophil, Lung, Cervix, T Cells

Publications for Perinatal Necrotizing Enterocolitis

Variations for Perinatal Necrotizing Enterocolitis

Expression for Perinatal Necrotizing Enterocolitis

Search GEO for disease gene expression data for Perinatal Necrotizing Enterocolitis.

Pathways for Perinatal Necrotizing Enterocolitis

Pathways related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.99 CRP CXCL8 EGF HBEGF IL1B IL6
2
Show member pathways
13.4 CXCL8 EGF IL1B IL6 THPO TLR4
3
Show member pathways
13.28 CXCL8 EGF HBEGF IL1B IL6 PLA2G7
4
Show member pathways
13.17 EGF HBEGF IL1B TLR4 TLR9 TNF
5
Show member pathways
12.97 CXCL8 IL1B IL6 SIGIRR TLR4 TLR9
6
Show member pathways
12.82 CXCL8 IL1B IL6 SIGIRR TLR4 TLR9
7
Show member pathways
12.8 CXCL8 IL1B IL6 TLR4 TLR9 TNF
8
Show member pathways
12.62 IL1B SIGIRR TLR4 TLR9 TNF
9
Show member pathways
12.59 EGF IL1B IL6 THPO TLR4 TLR9
10
Show member pathways
12.56 IL1B IL6 TLR4 TNF
11
Show member pathways
12.33 CXCL8 IL1B IL6 TNF
12
Show member pathways
12.26 CXCL8 IL1B IL6 TLR4 TNF
13 12.23 IL1B IL6 TLR4 TLR9 TNF
14 12.19 CXCL8 IL1B IL6 TNF
15
Show member pathways
12.18 CXCL8 IL1B IL6 TNF
16 12.17 EGF IL6 TLR4 TLR9 TNF
17 12.02 CXCL8 IL1B IL6 TNF
18 12.01 CXCL8 IL1B IL6 TLR4 TNF
19
Show member pathways
11.99 IL1B TLR4 TLR9
20 11.96 IL6 THPO TNF
21
Show member pathways
11.95 CXCL8 IL1B IL6 TLR4 TLR9 TNF
22 11.94 CXCL8 IL1B IL6 TNF
23 11.93 IL1B IL6 THPO TNF
24
Show member pathways
11.93 IL1B IL6 TLR4 TLR9
25 11.92 IL1B IL6 TNF
26 11.92 EGF HBEGF IL6 THPO
27 11.91 CXCL8 IL1B IL6
28 11.91 CXCL8 IL1B TLR4 TNF
29
Show member pathways
11.9 IL1B IL6 TLR4 TLR9 TNF
30 11.88 EGF IL6 TLR4
31
Show member pathways
11.85 CXCL8 IL6 TLR4
32 11.85 CXCL8 IL1B IL6 TLR4
33 11.84 CXCL8 IL1B IL6 TLR4 TNF
34 11.79 IL1B IL6 TLR9 TNF
35 11.76 CXCL8 IL1B IL6 TLR4 TNF
36 11.74 CXCL8 EGF HBEGF
37 11.74 IL6 TLR4 TLR9 TNF
38 11.68 CXCL8 HBEGF IL6
39
Show member pathways
11.68 CXCL8 IL1B IL6 TNF
40 11.65 CXCL8 IL1B IL6 TLR4 TNF
41 11.57 HBEGF IL6 TNF
42 11.54 IL1B TLR4 TNF
43 11.54 CXCL8 IL1B IL6 TNF
44 11.51 IL1B IL6 TNF
45 11.37 IL1B IL6 TLR9 TNF
46 11.36 IL1B IL6 TLR4 TNF
47 11.35 IL1B IL6 TNF
48 11.35 CXCL8 EGF IL1B IL6 TNF
49 11.33 IL1B IL6 TNF
50 11.32 IL1B IL6 TNF

GO Terms for Perinatal Necrotizing Enterocolitis

Cellular components related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 CRP CXCL8 EGF HBEGF IL1B IL6
2 extracellular space GO:0005615 9.36 CRP CXCL8 EGF HBEGF IL1B IL6

Biological processes related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

(show all 47)
id Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.96 EGF HBEGF IL1B TNF
2 positive regulation of gene expression GO:0010628 9.93 CRP IL1B IL6 TLR4 TLR9 TNF
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.91 IL6 THPO TLR4 TNF
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.9 IL1B TLR4 TLR9 TNF
5 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.87 IL1B IL6 TNF
6 defense response to Gram-positive bacterium GO:0050830 9.85 CRP IL6 TNF
7 cellular response to lipopolysaccharide GO:0071222 9.85 CXCL8 IL6 TLR4 TNF
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.84 EGF HBEGF IL6
9 defense response to Gram-negative bacterium GO:0050829 9.83 IL6 TLR4 TLR9
10 positive regulation of inflammatory response GO:0050729 9.81 PLA2G7 TLR4 TLR9
11 activation of MAPK activity GO:0000187 9.81 EGF IL1B TLR4 TNF
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.8 HBEGF IL6 TNF
13 positive regulation of protein kinase B signaling GO:0051897 9.8 HBEGF IL6 THPO TNF
14 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 IL1B IL6 TLR4 TLR9 TNF
15 inflammatory response GO:0006954 9.8 CRP CXCL8 IL1B IL6 TLR4 TLR9
16 positive regulation of JNK cascade GO:0046330 9.78 IL1B TLR4 TLR9 TNF
17 positive regulation of interferon-gamma production GO:0032729 9.76 IL1B TLR4 TNF
18 acute-phase response GO:0006953 9.73 CRP IL6 SIGIRR
19 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 IL1B TLR4 TNF
20 embryonic digestive tract development GO:0048566 9.7 CXCL8 TNF
21 negative regulation of lipid catabolic process GO:0050995 9.7 IL1B TNF
22 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.7 IL1B TNF
23 negative regulation of interleukin-6 production GO:0032715 9.7 TLR4 TLR9 TNF
24 negative regulation of ERBB signaling pathway GO:1901185 9.69 EGF HBEGF
25 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.69 IL1B TNF
26 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.68 TLR4 TLR9
27 response to molecule of bacterial origin GO:0002237 9.68 CXCL8 TLR9
28 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.68 IL1B TNF
29 I-kappaB phosphorylation GO:0007252 9.67 TLR4 TLR9
30 regulation of cytokine secretion GO:0050707 9.67 TLR4 TLR9
31 positive regulation of nitric oxide biosynthetic process GO:0045429 9.67 IL1B IL6 TLR4 TNF
32 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.66 IL1B TLR9
33 positive regulation of chemokine biosynthetic process GO:0045080 9.65 IL1B TNF
34 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.65 TLR4 TNF
35 regulation of establishment of endothelial barrier GO:1903140 9.63 IL1B TNF
36 positive regulation of interferon-beta biosynthetic process GO:0045359 9.63 TLR4 TLR9
37 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.62 IL6 TNF
38 positive regulation of interleukin-8 production GO:0032757 9.62 IL1B TLR4 TLR9 TNF
39 positive regulation of fever generation GO:0031622 9.61 IL1B TNF
40 negative regulation of lipid storage GO:0010888 9.61 CRP IL6 TNF
41 sequestering of triglyceride GO:0030730 9.59 IL1B TNF
42 negative regulation of chemokine biosynthetic process GO:0045079 9.58 IL6 SIGIRR
43 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.57 IL1B TNF
44 positive regulation of NF-kappaB import into nucleus GO:0042346 9.46 IL1B TLR4 TLR9 TNF
45 positive regulation of chemokine production GO:0032722 9.26 IL6 TLR4 TLR9 TNF
46 positive regulation of interleukin-6 production GO:0032755 9.02 IL1B IL6 TLR4 TLR9 TNF
47 immune response GO:0006955 10.04 CXCL8 IL1B IL6 TLR4 TNF

Molecular functions related to Perinatal Necrotizing Enterocolitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 EGF HBEGF IL6 THPO
2 interleukin-1 receptor binding GO:0005149 9.16 IL1B TLR9
3 cytokine activity GO:0005125 9.02 CXCL8 IL1B IL6 THPO TNF

Sources for Perinatal Necrotizing Enterocolitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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