Periodic Fever malady

Wikipedia: The periodic fever syndromes (also known as autoinflammatory syndromes) are a set of disorders, many of...⁴⁴ more...

MalaCards: Periodic Fever is related to periodic fever, familial, autosomal dominant and familial mediterranean fever. An important gene associated with Periodic Fever is TNFRSF1A (tumor necrosis factor receptor superfamily, member 1A), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/IAP pathway. The compounds ivig and n acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include monocytes, and related mouse phenotypes are hematopoietic system and skeleton.

periodic fever 7 43

Diseases related to periodic fever by text searches and GeneDecks gene sharing:

(show top 50)    (show all 506)

id	Related Disease	Score	Top Affiliating Genes
1	periodic fever, familial, autosomal dominant	33.4	MVK, MEFV, TNF, TNFRSF1A
2	familial mediterranean fever	31.8	MEFV, TNF, TNFRSF1A, NLRP3
3	hyper-igd syndrome	30.7	MVK, SAA1, IL1RN, TNF, TNFRSF1A, CRP
4	mevalonic aciduria	30.6	MVK, IL1RN, NLRP3
5	stomatitis	28.2	MEFV, IL1B, IL1RN, IFNG, TNF
6	behcet's disease	28.0	MEFV, TNF, TNFRSF1B, CRP
7	aphthous stomatitis	28.0	MVK, MEFV, IL1B, IL1RN, IFNG, TNF
8	amyloidosis	27.6	SAA1, MEFV, IL1B, IL1R1, IL1RAPL2, IL1RN
9	familial cold autoinflammatory syndrome	27.5	MEFV, IL1B, IL1R1, TNFRSF1A, NLRP3
10	twinning	26.3	MVK, IL1R1, IFNG, TNF, TNFRSF1A, TNFRSF1B
11	schnitzler syndrome	26.0	IL1R1, IL1RAPL2, IL1RN, TNF, CRP, NLRP3
12	wells syndrome	25.5	MEFV, IL1B, IL1R1, IL1RAPL2, TNFRSF1A, CRP
13	muckle-wells syndrome	25.5	MEFV, IL1B, IL1R1, IL1RAPL2, TNFRSF1A, CRP
14	blindness	21.3	SAA1, IL1B, IL1R1, IL1RAPL2, IL1RN, ANXA5
15	relapsing fever	13.5	MVK, MEFV, TNFRSF1A
16	amyloidosis, renal	13.4	SAA1, MEFV
17	colchicine resistance	13.3	MEFV, IL1R1
18	tuberculous uveitis	13.3	IFNG, TNF
19	chronic meningitis	13.3	CRP, NLRP3
20	cold agglutinin disease	13.2	TNF, CRP
21	epidural abscess	13.2	TNF, CRP
22	central nervous system leukemia	13.2	IL1B, TNF
23	mucocutaneous leishmaniasis	13.2	IFNG, TNF
24	aseptic meningitis	13.2	IL1R1, NLRP3
25	fissured tongue	13.1	IL1B, TNF
26	pleural tuberculosis	13.1	IFNG, TNF
27	staphylococcal toxic shock syndrome	13.1	IL1B, TNF
28	endotoxin hyporesponsiveness	13.1	IL1B, TNF
29	amyloidosis, secondary	13.1	SAA1, MEFV, CRP
30	familial combined hyperlipidemia	13.1	HMGCR, TNF, TNFRSF1A
31	fasciitis	13.1	IFNG, TNF, TNFRSF1A
32	bagassosis	13.1	IL1B, TNF
33	pyogenic arthritis, pyoderma gangrenosum and acne	13.0	MEFV, IL1B, PSTPIP1
34	arthritis	13.0	IL1B, TNF, TNFRSF1A
35	post-transplant lymphoproliferative disease	13.0	IL1R1, TNF, TNFRSF1A, TNFRSF1B
36	sympathetic ophthalmia	13.0	TNF, TNFRSF1A
37	microscopic polyangiitis	13.0	TNF, TNFRSF1B, CRP
38	deep vein thrombosis	13.0	TNF, TNFRSF1A, CRP
39	cowpox	13.0	XIAP, TNFRSF1A, CRP
40	obsessive-compulsive disorder	13.0	HTR1A, HMGCR, TNF
41	pulmonary plasma cell granuloma	13.0	MIF, IFNG, TNF
42	iga glomerulonephritis	13.0	MIF, MEFV, IL1R1
43	gastric cancer risk after h. pylori infection	12.9	IL1B, IL1RN
44	mixed connective tissue disease	12.9	TNF, TNFRSF1B, CRP
45	cluttering	12.9	ANXA5, IFNG
46	mycobacterium avium complex disease	12.9	IFNG, TNF
47	marek disease	12.9	HMGCR, TNFRSF1B
48	guillain-barre syndrome	12.9	IFNG, TNF, TNFRSF1A, TNFRSF1B
49	lepromatous leprosy	12.8	IL1RN, IFNG, TNF
50	omenn syndrome	12.8	IL1RN, IFNG, TNF

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to periodic fever:

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MGI Mouse Phenotypes related to periodic fever:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.6	XIAP, MIF, MEFV, NLRP12
2	skeleton phenotype	MP:0005390	9.4	TNFRSF1B, IL1R1, MEFV, TNFRSF1A
3	liver/biliary system phenotype	MP:0005370	8.9	IL1R1, MEFV, IFNG, NLRP3
4	immune system phenotype	MP:0005387	8.6	MEFV, NLRP12, PSTPIP1, TNFRSF1A, TNF, IFNG
5	integument phenotype	MP:0010771	8.5	XIAP, MEFV, IL1R1, IFNG, TNFRSF1A, TNFRSF1B
6	tumorigenesis	MP:0002006	7.8	IL1B, IFNG, TNFRSF1A, TNFRSF1B, PLA2G2A, NLRP12
7	homeostasis/metabolism phenotype	MP:0005376	7.6	IL1RN, HTR1A, TNFRSF1A, TNFRSF1B, CRP, NLRP12
8	mortality/aging	MP:0010768	7.2	HMGCR, TNFRSF1A, HTR1A, IFNG, IL1R1, IL1B
9	cardiovascular system phenotype	MP:0005385	6.7	TNF, TNFRSF1A, HTR1A, CRP, XIAP, TNFRSF1B

Articles related to periodic fever:

(show top 50)    (show all 60)

id	Title	Authors	Year	Affiliating Genes
1	Identification and functional consequences of a recur rent NLRP12 missense mutation in periodic fever syndromes. (21538323)	JAcru I.... Amselem S.	2011	NLRP12
2	The Familial Mediterranean Fever Gene as a Modifier o f Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenopathy Syndrome. (20828792)	Berkun Y.... Padeh S.	2010	MEFV
3	A novel Y331X nonsense mutation in TNFRSF1A gene in t wo unrelated Turkish families with periodic fever syndrome. (19804406)	Kutukculer N.... Berdeli A.	2010	TNFRSF1A, MVK, MEFV
4	A monoallelic double mutation as a cause for TNF rece ptor-associated periodic fever syndrome. (19547977)	TrA1benbach J.... Steinberger D.	2010	TNF
5	The 423Q polymorphism of the X-linked inhibitor of ap optosis gene influences monocyte function and is associated with periodic fever . (19877056)	Ferretti M.... Dianzani U.	2009	TNF, TNFRSF1A, MVK
6	Periodic fever syndrome/autoinflammatory syndrome (19255765)	KAPtter I.... KA1mmerle-Deschner J.B.	2009	TNF
7	A diagnostic score for molecular analysis of hereditary autoinflammatory syndromes with periodic fever in children. (18512793)	Gattorno M.... Martini A.	2008	TNFRSF1A, MVK, MEFV
8	Clinical and functional characterisation of a novel TNFRSF1A c.605T>A/V173D cleavage site mutation associated with tumour necrosis factor receptor-associated periodic fever syndrome (TRAPS), cardiovascular complications and excellent response to etanercept treatment. (18180277)	Stojanov S.... Schirmer M.	2008	ANXA5, TNFRSF1A
9	Mutations in NALP12 cause hereditary periodic fever syndromes. (18230725)	Jeru I.... Amselem S.	2008	NLRP12
10	Serum macrophage migration inhibitory factor (MIF) in the intercritical phase of hereditary periodic fevers and its relationship with the MIF-173G/C polymorphism. (17763209)	Rigante D.... Stabile A.	2007	MIF
11	Falling into TRAPS--receptor misfolding in the TNF receptor 1-associated periodic fever syndrome. (17666110)	Kimberley F.C.... Screaton G.R.	2007	TNF, TNFRSF1A
12	Treatment with anakinra in the hyperimmunoglobulinemia D/periodic fever syndrome. (16871408)	Rigante D.... Stabile A.	2006	IL1RAPL2
13	Muckle-Wells syndrome: a rare periodic fever syndrome (16901068)	Appels C.W.... Kloppenburg M.	2006	IL1R1, NLRP3
14	A complex case of renal amyloidosis with a rare co-occurrence of 2 mutations in separate hereditary periodic fever syndrome-related genes. (17048217)	Cigni A.... Satta A.E.	2006	TNF
15	A decision tree for genetic diagnosis of hereditary periodic fever in unselected patients. (16707534)	Federici L.... Touitou I.	2006	MEFV
16	A Dutch family with the hereditary periodic fever or tumour necrosis factor receptor-associated periodic syndrome (TRAPS) (17194009)	Chang Pan Huo N.M.... Kwee M.L.	2006	TNF
17	AA amyloidosis complicating hyperimmunoglobulinemia D with periodic fever syndrome: a report of two cases. (16732551)	Lachmann H.J.... Hawkins P.N.	2006	TNF, MVK
18	Periodic fever in children with hyperimmunoglobulinemia D and mevalonate kinase mutations. (15933578)	Grose C.	2005	MVK
19	Autosomal dominant periodic fever with AA amyloidosis: tumor necrosis factor receptor-associated periodic syndrome (TRAPS) in a Turkish family. (16299693)	Dinc A.... Lachmann H.	2005	TNF
20	Behcet's disease and hereditary periodic fever syndromes: casual association or causal relationship? (16273767)	Espinosa G.... Font J.	2005	TNF, MEFV
21	Tumor necrosis factor receptor-associated periodic syndrome in a young adult who had features of periodic fever, aphthous stomatitis, pharyngitis, and adenitis as a child. (15689926)	Saulsbury F.T.... Wispelwey B.	2005	TNF
22	Hereditary periodic fever and reactive amyloidosis. (16284730)	van der Hilst J.C.... Drenth J.P.	2005	SAA1
23	Pseudodominant inheritance of the hyperimmunoglobulinemia D with periodic fever syndrome in a mother and her two monozygotic twins. (16255052)	Hospach T.... Lohse P.	2005	MVK
24	Allelic variants in genes associated with hereditary periodic fever syndromes as susceptibility factors for reactive systemic AA amyloidosis. (15071491)	Aganna E.... McDermott M.F.	2004	TNF, TNFRSF1A, MEFV
25	A novel tumour necrosis factor receptor mutation in a Finnish family with periodic fever syndrome. (15228183)	Stjernberg-Salmela S.... Ranki A.	2004	TNF, TNFRSF1A
26	Hereditary periodic fever (15243709)	Lamprecht P.... Gross W.L.	2004	TNF, MEFV
27	A common pathway in periodic fever syndromes. (15324736)	McDermott M.F.	2004	MEFV, PSTPIP1
28	First report of systemic reactive (AA) amyloidosis in a patient with the hyperimmunoglobulinemia D with periodic fever syndrome. (15457465)	Obici L.... Merlini G.	2004	TNF
29	Periodic fever, mild arthralgias, and reversible moderate and severe organ inflammation associated with the V198M mutation in the CIAS1 gene in three German patients--expanding phenotype of CIAS1 related autoinflammatory syndrome. (15245511)	Porksen G.... Roesler J.	2004	NLRP3
30	Molecular analysis of the MVK and TNFRSF1A genes in patients with a clinical presentation typical of the hyperimmunoglobulinemia D with periodic fever syndrome: a low-penetrance TNFRSF1A variant in a heterozygous MVK carrier possibly influences the phenotype of hyperimmunoglobulinemia D with periodic fever syndrome or vice versa. (15188372)	Stojanov S.... Belohradsky B.H.	2004	TNF, TNFRSF1A, MVK
31	Simvastatin treatment for inflammatory attacks of the hyperimmunoglobulinemia D and periodic fever syndrome. (15116060)	Simon A.... Drenth J.P.	2004	MVK, HMGCR
32	Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation. (12861380)	Houten S.M.... Waterham H.R.	2003	MVK
33	Carrier frequency of the V377I (1129G>A) MVK mutation, associated with Hyper-IgD and periodic fever syndrome, in the Netherlands. (12634869)	Houten S.M.... Waterham H.R.	2003	MVK
34	Favorable preliminary experience with etanercept in two patients with the hyperimmunoglobulinemia D and periodic fever syndrome. (13130485)	Takada K.... Kastner D.L.	2003	TNF, MVK
35	Temperature dependence of mutant mevalonate kinase activity as a pathogenic factor in hyper-IgD and periodic fever syndrome. (12444096)	Houten S.M.... Waterham H.R.	2002	MVK
36	Hereditary periodic fever syndromes. (11583827)	McDermott M.F.... Frenkel J.	2001	MVK, MEFV
37	Limited efficacy of thalidomide in the treatment of febrile attacks of the hyper-IgD and periodic fever syndrome: a randomized, double-blind, placebo-controlled trial. (11504824)	Drenth J.P.... Van der Meer J.W.	2001	TNFRSF1B, IL1B, CRP
38	Genetic analysis as a valuable key to diagnosis and t reatment of periodic Fever. (11700162)	Simon A.... Drenth J.P.	2001	TNF, TNFRSF1A, TNFRSF1B
39	Familial periodic fever and amyloidosis due to a new mutation in the TNFRSF1A gene. (11239851)	Simon A.... Drenth J.P.	2001	TNFRSF1A
40	Molecular analysis of MVK mutations and enzymatic activity in hyper- IgD and periodic fever syndrome. (11313769)	Cuisset L.... Delpech M.	2001	MVK
41	Organization of the mevalonate kinase (MVK) gene and identification of novel mutations causing mevalonic aciduria and hyperimmunoglobulinaemia D and periodic fever syndrome. (11313768)	Houten S.M.... Waterham H.R.	2001	MVK
42	Mevalonate kinase deficiency in a child with periodic fever and without hyperimmunoglobulinaemia D. (11486909)	Di Rocco M.... Wanders R.J.	2001	MVK
43	Characterization of mevalonate kinase V377I, a mutant implicated in defective isoprenoid biosynthesis and HIDS/periodic fever syndrome. (11325608)	Rios S.E.... Miziorko H.M.	2001	MVK
44	Clinical and molecular variability in childhood periodic fever with hyperimmunoglobulinaemia D. (11371670)	Frenkel J.... Kuis W.	2001	MVK
45	Molecular analysis of the mevalonate kinase gene in a cohort of patients with the hyper-igd and periodic fever syndrome: its application as a diagnostic tool. (11529697)	Simon A.... Drenth J.P.	2001	MVK
46	Mevalonate kinase deficiency and Dutch type periodic fever. (10949735)	Frenkel J.... Kuis W.	2000	MVK
47	A homozygous M694V mutation of the MEFV gene in a patient with periodic fever and thoracic pain. (10667038)	van de Loosdrecht A.A.... Hazenberg B.P.	2000	MEFV
48	The hereditary periodic fever syndromes: molecular analysis of a new family of inflammatory diseases. (9735379)	Centola M.... Kastner D.L.	1998	MEFV
49	Cytokine activation during attacks of the hyperimmunoglobulinemia D and periodic fever syndrome. (7780142)	Drenth J.P.... Van der Meer J.W.	1995	PLA2G2A, IL1RN
50	Interferon-gamma and urine neopterin in attacks of the hyperimmunoglobulinaemia D and periodic fever syndrome. (7498243)	Drenth J.P.... Van der Meer J.W.	1995	IFNG

Genes related to periodic fever according to GeneCards:

(show all 21)

id	Symbol	Description	Score	GeneCards Section Context
1	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	11.1	Summaries, Publications
2	MEFV	Mediterranean fever	11.1	Publications, Summaries
3	MVK	mevalonate kinase	11.1	Publications, Summaries
4	TNF	tumor necrosis factor	11.0	Publications
5	HTR1A	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	11.0	Summaries
6	NLRP3	NLR family, pyrin domain containing 3	11.0	Publications
7	NLRP12	NLR family, pyrin domain containing 12	11.0	Publications
8	SAA1	serum amyloid A1	11.0	Publications
9	PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	11.0	Publications
10	MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	11.0	Publications
11	XIAP	X-linked inhibitor of apoptosis	11.0	Publications
12	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	11.0	Publications
13	PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)	11.0	Publications
14	IL1R1	interleukin 1 receptor, type I	11.0	Publications
15	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
16	ANXA5	annexin A5	11.0	Publications
17	HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase	11.0	Publications
18	CRP	C-reactive protein, pentraxin-related	11.0	Publications
19	IL1RAPL2	interleukin 1 receptor accessory protein-like 2	11.0	Publications
20	IL1B	interleukin 1, beta	11.0	Publications
21	IFNG	interferon, gamma	11.0	Publications

Pathways related to periodic fever according to GeneDecks:

(show top 50)    (show all 71)

id	Pathway	Score	Top Affiliating Genes
1	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.7	TNFRSF1A
2	Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/IAP pathway41	10.6	XIAP
3	Jak/Stat Pathway3	10.5	IL1RN
4	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.2	TNFRSF1A, TNF, TNFRSF1B
5	IL-9 Pathway36	10.1	TNF, TNFRSF1B, TNFRSF1A
6	14-3-3 and Regulation of BAD Activity36	10.1	TNFRSF1B, TNF, TNFRSF1A
7	Apoptosis and survival Caspase cascade10	10.1	TNFRSF1A, XIAP, TNF
8	Apoptosis and survival_Caspase cascade41	10.1	XIAP, TNF, TNFRSF1A
9	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway10	9.9	XIAP, TNFRSF1B, TNFRSF1A, TNF
10	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway10	9.9	TNFRSF1B, TNF, TNFRSF1A
11	Apoptosis and survival Apoptotic TNF-family pathways10	9.9	TNF, TNFRSF1A, TNFRSF1B, XIAP
12	Apoptosis and survival_Apoptotic TNF-family pathways41	9.9	XIAP, TNF, TNFRSF1A, TNFRSF1B
13	Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway41	9.9	TNF, TNFRSF1A, TNFRSF1B
14	Transcription_NF-kB signaling pathway41	9.8	TNFRSF1A, IL1R1, TNFRSF1B, TNF
15	Immune response MIF-mediated glucocorticoid regulation10	9.8	IFNG, TNF, MIF
16	Immune response_MIF-mediated glucocorticoid regulation41	9.8	MIF, IFNG, TNF
17	Cellular Transformation by HTLV136	9.7	TNFRSF1A, TNF, IFNG, TNFRSF1B
18	THC Differentiation Pathway36	9.7	IFNG, TNFRSF1B, TNF, TNFRSF1A
19	Apoptotic Pathways Triggered By HIV136	9.5	TNF, TNFRSF1A, TNFRSF1B
20	Toxoplasmosis20	9.4	IFNG, XIAP, TNF, TNFRSF1A, PLA2G2A
21	NF-kappaB Signaling3	9.3	TNFRSF1A, IL1B, TNF, TNFRSF1B
22	14-3-3 Induced Apoptosis36	9.3	IL1B, TNF, TNFRSF1A, IL1R1
23	Cytokine Network36	9.2	TNF, IFNG, IL1B
24	Immune System38	9.2	SAA1, NLRP3, IFNG, PSTPIP1, IL1R1, MEFV
25	MIF Mediated Glucocorticoid Regulation36	9.1	PLA2G2A, TNF, IL1B, MIF
26	African trypanosomiasis20	9.1	IFNG, IL1B, TNF
27	Chagas disease (American trypanosomiasis)20	9.1	IL1B, IFNG, TNF, TNFRSF1A
28	MIF Regulation of Innate Immune Cells36	9.1	TNF, PLA2G2A, IL1B, MIF
29	Apoptosis20	9.1	IL1R1, IL1B, XIAP, TNFRSF1A, TNF
30	Immune response_MIF in innate immunity response41	9.1	IL1B, IFNG, MIF, TNF
31	Immune response MIF in innate immunity response10	9.1	MIF, TNF, IL1B, IFNG
32	SUMO Pathway36	9.1	TNFRSF1B, TNFRSF1A, TNF, IL1R1, IL1B
33	TRAF Pathway36	9.1	TNFRSF1A, TNF, IL1R1, IL1B, TNFRSF1B
34	PGC1Alpha Pathway36	9.0	TNFRSF1A, TNFRSF1B, IL1B, IL1R1
35	NF-KappaB (p50-p65) Pathway36	9.0	IL1B, IL1R1, TNF, TNFRSF1A, TNFRSF1B
36	NF-KappaB Family Pathway36	9.0	TNF, IL1B, IL1R1, TNFRSF1A, TNFRSF1B
37	Type I diabetes mellitus20	9.0	IFNG, IL1B, TNF
38	STAT3 Pathway36	9.0	TNFRSF1B, TNFRSF1A, TNF, IL1R1, IL1B
39	Bacterial infections in CF airways41	9.0	IFNG, IL1R1, IL1B, TNF
40	NOD-like receptor signaling pathway20	9.0	TNF, XIAP, MEFV, IL1B, NLRP3, PSTPIP1
41	Influenza A20	8.9	IL1B, TNF, TNFRSF1A, NLRP3, IFNG
42	Amoebiasis20	8.9	IL1B, TNF, IFNG, IL1R1
43	MAPK signaling pathway20	8.9	PLA2G2A, IL1B, IL1R1, TNF, TNFRSF1A
44	HMGB1 Pathway36	8.9	IL1R1, IFNG, TNF, TNFRSF1A, IL1B
45	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	8.8	IFNG, IL1B, TNF
46	Osteoclast differentiation20	8.8	IFNG, TNFRSF1A, IL1R1, TNF, IL1B
47	Immune response_Bacterial infections in normal airways41	8.8	IL1B, IL1R1, IFNG
48	Antioxidant Action of Vitamin-C36	8.7	IL1B, IL1R1, TNF, TNFRSF1A, TNFRSF1B, PLA2G2A
49	MAPK Family Pathway36	8.6	TNF, IL1R1, IL1B, TNFRSF1B, TNFRSF1A
50	Cytokine-cytokine receptor interaction20	8.5	IL1B, TNFRSF1B, IFNG, IL1R1, TNF, TNFRSF1A

Compounds related to periodic fever according to GeneDecks:

(show top 50)    (show all 153)

id	Compound	Score	Top Affiliating Genes
1	ivig32	9.8	IL1RAPL2, CRP
2	n acetylcysteine32	9.6	ANXA5, IL1R1, HMGCR
3	c2ceramide32	9.6	IL1B, TNF, TNFRSF1A
4	mevalonate32	8.9	HMGCR, NLRP3, TNFRSF1A, MEFV, MVK
5	pge232	8.9	IL1R1, TNFRSF1B, PLA2G2A, IL1RN, IL1RAPL2
6	sb 20358032 42	9.9	ANXA5, IL1R1, IFNG, CRP, TNF
7	acth32	8.8	MIF, IL1B, IL1R1, IL1RN
8	tenidap42 32	9.7	CRP, TNF, SAA1, IL1B, IL1R1
9	rantes32	8.6	IL1R1, TNFRSF1B, IL1RAPL2, IFNG, MIF, TNFRSF1A
10	gold sodium thiomalate32	8.6	IL1RN, IL1R1, TNF, IL1B, IFNG
11	thalidomide32 42 9 9	11.5	XIAP, TNFRSF1B, TNFRSF1A, TNF, IFNG, IL1B
12	amphotericin b32	8.4	IL1RN, CRP, IFNG, IL1R1, IL1RAPL2
13	leflunomide32 9 9	10.3	IL1B, IL1RAPL2, TNFRSF1A, IL1RN, TNF, IL1R1
14	ibuprofen32 9 18 9	11.3	TNFRSF1B, PLA2G2A, IL1B, IL1RN, IL1R1
15	adalimumab32 9 9	10.3	IL1R1, CRP, TNF, IFNG, IL1RN, IL1RAPL2
16	curcumin32	8.3	XIAP, IL1B, TNFRSF1B, ANXA5, TNF, TNFRSF1A
17	endotoxin32	8.2	MEFV, IL1R1, IL1RAPL2, TNFRSF1A, TNFRSF1B, CRP
18	cuprophan32	8.2	IL1RN, IL1RAPL2, IL1R1, IL1B, TNFRSF1A, TNFRSF1B
19	pdtc32	8.2	PLA2G2A, TNF, IFNG, ANXA5, IL1B, XIAP
20	corticosterone32 18	9.2	IL1B, IL1R1, IL1RAPL2, IL1RN, MIF
21	polysulfone32	8.1	IL1RAPL2, IL1R1, CRP, IL1RN, IL1B
22	sulfasalazine32 9 9	10.0	IL1RAPL2, IL1R1, IL1B, CRP, TNF, IL1RN
23	prednisolone32 9 9	10.0	CRP, TNF, IFNG, IL1RN, IL1RAPL2, IL1R1
24	hydrocortisone32 9 9	9.9	IL1R1, MIF, IL1B, IL1RN, IFNG, TNF
25	leukotriene b432 42 18	9.9	TNF, PLA2G2A, IL1B, IL1R1, IL1RAPL2, IL1RN
26	fmlp32	7.9	TNF, PLA2G2A, IL1RN, IL1B, IL1RAPL2, TNFRSF1B
27	norepinephrine32 9 18 9	10.9	TNFRSF1A, IL1RN, CRP, MIF, IL1R1, IL1RAPL2
28	fibrinogen32	7.7	ANXA5, IL1R1, IL1RAPL2, SAA1, TNF, CRP
29	il 1032	7.7	IL1RAPL2, IL1RN, IFNG, TNF, TNFRSF1B, IL1R1
30	pentoxifylline32 9 9	9.7	PLA2G2A, TNF, IFNG, IL1RN, IL1R1, IL1RAPL2
31	anakinra32 9 9	9.6	IL1R1, IL1B, MVK, IL1RAPL2, NLRP3, CRP
32	creatinine32	7.4	HMGCR, IL1RN, TNFRSF1A, IL1RAPL2, IL1R1, MIF
33	lactate32	7.3	MIF, IL1R1, IL1RAPL2, IL1RN, ANXA5, HMGCR
34	superoxide32 18	8.3	TNFRSF1A, IL1B, IL1RAPL2, IL1RN, ANXA5, TNF
35	simvastatin32 34 42 9 18 9	12.2	SAA1, CRP, TNFRSF1A, TNF, HMGCR, IFNG
36	cyclosporin a32 42	8.1	IL1R1, ANXA5, TNFRSF1B, TNFRSF1A, IL1RAPL2, IL1RN
37	cholesterol32 9 18 9	10.1	MVK, SAA1, IL1R1, IL1RAPL2, IL1RN, TNFRSF1A
38	h2o232	7.1	IL1RN, ANXA5, PLA2G2A, IL1RAPL2, IL1R1, XIAP
39	indomethacin32 9 9	9.1	PLA2G2A, TNF, IFNG, ANXA5, TNFRSF1A, IL1B
40	etanercept32 9 9	9.0	TNF, IFNG, IL1RN, IL1RAPL2, IL1R1, CRP
41	neopterin32	7.0	IL1B, IL1R1, IL1RAPL2, IL1RN, IFNG, TNF
42	methotrexate32 34 42 9 9	10.9	IL1B, NLRP3, CRP, TNFRSF1B, TNFRSF1A, TNF
43	serine32	6.7	MVK, IL1RAPL2, PSTPIP1, NLRP12, PLA2G2A, TNFRSF1B
44	lipid32	6.7	TNF, TNFRSF1A, TNFRSF1B, CRP, PLA2G2A, SAA1
45	infliximab32 9 9	8.6	TNF, TNFRSF1A, TNFRSF1B, CRP, IL1R1, IL1RAPL2
46	actinomycin d32	6.4	ANXA5, IL1RAPL2, IL1R1, IL1B, IFNG, HMGCR
47	retinoic acid32 42 18	8.2	IFNG, IL1B, TNF, PLA2G2A, ANXA5, IL1RN
48	dexamethasone32 42 34 9 9	9.6	TNF, HMGCR, IFNG, ANXA5, IL1RN, IL1RAPL2
49	cycloheximide32	5.6	XIAP, PLA2G2A, IL1B, IL1R1, IL1RAPL2, IL1RN
50	vegf32	5.3	TNF, TNFRSF1A, TNFRSF1B, CRP, PLA2G2A, IFNG

Cellular components related to periodic fever according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	7.0	PLA2G2A, CRP, TNFRSF1A, TNF, IFNG, IL1RN
2	extracellular region	GO:005576	7.0	PLA2G2A, CRP, TNFRSF1B, TNFRSF1A, IFNG, IL1R1

Biological processes related to periodic fever according to GeneDecks:

(show all 28)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cytokine secretion	GO:050715	10.1	SAA1, MIF, TNF
2	positive regulation of vitamin D biosynthetic process	GO:060557	10.1	TNF, IFNG
3	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	GO:035872	10.1	MEFV, NLRP3, PSTPIP1
4	positive regulation of inflammatory response	GO:050729	10.0	TNFRSF1A, PLA2G2A, NLRP12
5	negative regulation of gene expression	GO:010629	10.0	MIF, TNF, TNFRSF1A
6	negative regulation of lipid storage	GO:010888	10.0	CRP, TNF
7	positive regulation of interleukin-1 beta secretion	GO:050718	9.8	IFNG, NLRP12, NLRP3
8	sequestering of triglyceride	GO:030730	9.8	IL1B, TNF
9	positive regulation of heterotypic cell-cell adhesion	GO:034116	9.7	TNF, IL1B
10	positive regulation of tyrosine phosphorylation of Stat1 protein	GO:042511	9.7	IFNG, TNFRSF1A
11	acute-phase response	GO:006953	9.6	CRP, SAA1, IL1RN
12	positive regulation of fever generation	GO:031622	9.6	TNF, IL1B
13	negative regulation of glutamate secretion	GO:014050	9.5	IL1B, IL1RN
14	chronic inflammatory response to antigenic stimulus	GO:002439	9.4	IL1B, TNF, IL1RN
15	negative regulation of inflammatory response	GO:050728	9.3	TNFRSF1B, NLRP12, NLRP3, TNFRSF1A, MEFV, SAA1
16	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.3	IFNG, IL1B, TNF
17	positive regulation of chemokine biosynthetic process	GO:045080	9.3	TNF, IFNG, IL1B
18	positive regulation of nitric oxide biosynthetic process	GO:045429	9.3	IL1B, IFNG, TNF
19	neutrophil chemotaxis	GO:030593	9.2	SAA1, IFNG, IL1B
20	positive regulation of interleukin-6 biosynthetic process	GO:045410	9.2	IL1B, IFNG
21	ovulation	GO:030728	9.0	IL1R1, IL1B
22	positive regulation of membrane protein ectodomain proteolysis	GO:051044	9.0	IFNG, IL1B, TNF, TNFRSF1B
23	response to hypoxia	GO:001666	9.0	IL1B, TNF, TNFRSF1A, CRP
24	innate immune response	GO:045087	8.9	IL1RAPL2, NLRP3, IL1R1, MEFV, MIF, PSTPIP1
25	regulation of insulin secretion	GO:050796	8.9	IFNG, TNF, IL1B
26	anti-apoptosis	GO:006916	8.8	ANXA5, XIAP, IL1B, TNF
27	apoptotic process	GO:006915	8.3	TNFRSF1A, IL1B, TNFRSF1B, TNF, IFNG, XIAP
28	inflammatory response	GO:006954	8.2	MIF, MEFV, TNF, TNFRSF1A, TNFRSF1B, CRP

Molecular functions related to periodic fever according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	interleukin-1 receptor activity	GO:004908	9.5	IL1R1, IL1RAPL2
2	protease binding	GO:002020	9.5	IL1R1, TNF, TNFRSF1A
3	cytokine activity	GO:005125	8.6	MIF, IL1B, IFNG, TNF