PFAPA
MCID: PRD012
MIFTS: 11

Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis (PFAPA) malady

Summaries for Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis

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43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (pfapa) is a periodic disease, which is a heterogeneous group of disorders characterized by short episodes of illness that regularly recur for several years alternated with healthy periods. pfapa is characterized by high fevers lasting three to six days and recurring every 21 to 28 days, accompanied by some or all of the signs noted in its name, namely mouth sores (aphthous stomatitis), sore throat (pharyngitis), and enlarged lymph nodes (cervical adenitis). the syndrome usually occurs in children younger than five years; although it has been reported in children up to 13 years. the syndrome is sporadic and non-hereditary. the course of pfapa can be persistent for years before spontaneous, full resolution. last updated: 10/7/2013

MalaCards: Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis, also known as marshall syndrome, is related to pharyngitis and aphthous stomatitis. An important gene associated with Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis is TNF (tumor necrosis factor). Affiliated tissues include lymph node.

Aliases & Classifications for Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis

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43NIH Rare Diseases, 61UMLS
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Aliases & Descriptions:

periodic fever, aphthous stomatitis, pharyngitis and adenitis 43
marshall syndrome 43 61
pfapa 43


Related Diseases for Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis

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17GeneCards, 18GeneDecks
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Diseases related to Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 17)
idRelated DiseaseScoreTop Affiliating Genes
1pharyngitis11.2
2aphthous stomatitis11.2
3stomatitis11.2
4marshall syndrome10.8
5adult syndrome10.6
6young syndrome10.6
7marshall syndrome with periodic fever10.2
8cutis laxa10.0
9stickler syndrome10.0
10syphilis10.0
11acquired cutis laxa10.0
12fanconi's anemia10.0
13proliferative glomerulonephritis10.0
14autoimmune hepatitis10.0
15kawasaki disease10.0
16hepatitis a10.0
17pityriasis lichenoides10.0

Graphical network of diseases related to Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis:



Diseases related to periodic fever, aphthous stomatitis, pharyngitis and adenitis

Clinical Features for Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis

Drugs & Therapeutics for Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Genetic Tests for Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis

Anatomical Context for Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis

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MalaCards organs/tissues related to Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis:

33
Lymph node

Animal Models for Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis or affiliated genes

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28inGenious Targeting Laboratory
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Publications for Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis

Genetic Variations for Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis

Expression for genes affiliated with Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis

Search GEO for disease gene expression data for Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis.

Pathways for genes affiliated with Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis

Compounds for genes affiliated with Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis

GO Terms for genes affiliated with Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis

Products for genes affiliated with Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis

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Sources for Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet