MCID: PRD002
MIFTS: 40

Periodic Limb Movement Disorder malady

Categories: Mental diseases

Aliases & Classifications for Periodic Limb Movement Disorder

Aliases & Descriptions for Periodic Limb Movement Disorder:

Name: Periodic Limb Movement Disorder 12 52 14
Nocturnal Myoclonus Syndrome 42 69
Nocturnal Myoclonus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9207
ICD10 33 G47.61
ICD9CM 35 327.51
MeSH 42 D020189
SNOMED-CT 64 418763003
UMLS 69 C0751774

Summaries for Periodic Limb Movement Disorder

Disease Ontology : 12 A sleep disorder that involves involuntary limb movement during sleep.

MalaCards based summary : Periodic Limb Movement Disorder, also known as nocturnal myoclonus syndrome, is related to restless legs syndrome and polyneuropathy. An important gene associated with Periodic Limb Movement Disorder is GLRA1 (Glycine Receptor Alpha 1), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Monoamine GPCRs. The drugs Dopamine and Gabapentin have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and globus pallidus, and related phenotypes are Increased shRNA abundance (Z-score > 2) and behavior/neurological

Wikipedia : 71 Periodic limb movement disorder (PLMD), previously known as nocturnal myoclonus, is a sleep disorder... more...

Related Diseases for Periodic Limb Movement Disorder

Diseases related to Periodic Limb Movement Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
id Related Disease Score Top Affiliating Genes
1 restless legs syndrome 11.3
2 polyneuropathy 10.2 HTR1A HTR2A
3 antisocial personality disorder 10.2 HTR1A HTR2A
4 aryepiglottic fold cancer 10.2 HTR1A HTR2A
5 sleep apnea 10.2
6 nephronophthisis 13 10.2 HTR2A SLC6A4
7 intracranial cavernous angioma 10.2 DRD2 SLC6A4
8 splenic abscess 10.2 DRD2 HTR2A SLC6A4
9 allergic hypersensitivity disease 10.2 DRD2 HTR1A HTR2A
10 euthyroid sick syndrome 10.2 DRD2 HTR2A SLC6A4
11 ornithosis 10.2 DRD2 SLC6A4
12 vascular cancer 10.2 DRD2 HTR1A HTR2A
13 interstitial emphysema 10.2 DRD2 HTR2C SLC6A4
14 cardiovascular syphilis 10.2 HTR2C VPS13A
15 pyromania 10.2 DRD2 HTR2A SLC6A4
16 teratoma with malignant transformation 10.2 DRD2 HTR2A
17 apperceptive agnosia 10.1 DRD2 HTR1A SLC6A4
18 cholesteatoma 10.1 DRD2 HTR2C SLC6A4
19 anodontia 10.1 HTR1A HTR2C SLC6A4
20 cytomegalic congenital adrenal hypoplasia 10.1 DRD2 HTR2A SLC6A4
21 hereditary multiple exostoses 10.1 DRD2 HTR2A SLC6A4
22 hypoglycemic coma 10.1 HTR1A HTR2A SLC6A4
23 obstructive sleep apnea 10.1
24 hepatitis b reinfection following liver transplantation 10.1 HTR1A HTR2A SLC6A4
25 adult brainstem astrocytoma 10.1 HTR1A SLC6A4
26 lichen disease 10.1 HTR1A HTR2A SLC6A4
27 fechtner syndrome 10.1 HTR1A HTR2A SLC6A4
28 dry eye syndrome 10.0 HTR1A HTR2A HTR2C SLC6A4
29 postencephalitic parkinson disease 10.0 DRD2 HTR1A HTR2A SLC6A4
30 multiple personality disorder 10.0 HTR1A HTR2A HTR2C SLC6A4
31 hepatitis d 10.0 DRD2 HTR1A HTR2A SLC6A4
32 primary angle-closure glaucoma 10.0 HTR1A HTR2A HTR2C SLC6A4
33 keratosis 10.0 HTR1A HTR2A HTR2C SLC6A4
34 alzheimer disease 17 10.0 HTR1A HTR2A HTR2C SLC6A4
35 brain glioblastoma multiforme 10.0 DRD2 HTR1A HTR2A SLC6A4
36 neurogenic bladder 10.0 HTR2A SLC6A4
37 myoclonus 10.0
38 cecal benign neoplasm 10.0 DRD2 HTR1A HTR2A HTR2C SLC6A4
39 retinoblastoma 10.0 DRD2 HTR1A HTR2A HTR2C SLC6A4
40 chronic conjunctivitis 10.0 DRD2 HTR1A HTR2A HTR2C SLC6A4
41 benign epilepsy with centrotemporal spikes 9.9 DRD2 HTR1A HTR2A HTR2C SLC6A4
42 personality disorder 9.9 DRD2 HTR1A HTR2A HTR2C SLC6A4
43 microcephaly 13, primary, autosomal recessive 9.9 DRD2 HTR1A HTR2A HTR2C SLC6A4
44 ellis-van creveld syndrome 9.9 DRD2 HTR1A HTR2A HTR2C SLC6A4
45 preeclampsia/eclampsia 5 9.9 DRD2 HTR1A HTR2A HTR2C SLC6A4
46 cortical deafness 9.9 CTNNBL1 KANTR
47 attention deficit-hyperactivity disorder 9.9
48 sleep disorder 9.9
49 epilepsy 9.8
50 focal epilepsy 9.8

Graphical network of the top 20 diseases related to Periodic Limb Movement Disorder:



Diseases related to Periodic Limb Movement Disorder

Symptoms & Phenotypes for Periodic Limb Movement Disorder

GenomeRNAi Phenotypes related to Periodic Limb Movement Disorder according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.84 FXYD1 HTR2C
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.84 HTR2C
3 Increased shRNA abundance (Z-score > 2) GR00366-A-106 9.84 HTR2C
4 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.84 FXYD1 HTR2C SLC6A4 CTNNBL1 DRD2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.84 CTNNBL1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.84 FXYD1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.84 CTNNBL1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.84 DRD2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.84 CTNNBL1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.84 FXYD1 DRD2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.84 CTNNBL1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.84 SLC6A4
13 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.84 DRD2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.84 HTR2C
15 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.84 SLC6A4
16 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.84 FXYD1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.84 FXYD1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.84 CTNNBL1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.84 FXYD1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.84 DRD2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.84 DRD2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.84 SLC6A4
23 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.84 HTR2C
24 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.84 HTR2C
25 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.84 DRD2
26 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.84 SLC6A4
27 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.84 CTNNBL1

MGI Mouse Phenotypes related to Periodic Limb Movement Disorder:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.61 ZEB1 DRD2 GLRA1 HTR1A HTR2A HTR2C
2 muscle MP:0005369 9.17 DRD2 FXYD1 GLRA1 HTR2A HTR2C SLC6A4

Drugs & Therapeutics for Periodic Limb Movement Disorder

Drugs for Periodic Limb Movement Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
2
Gabapentin Approved, Investigational Phase 4,Phase 3 60142-96-3 3446
3
Benzocaine Approved Phase 4,Phase 3 1994-09-7, 94-09-7 2337
4
Iron Approved Phase 4,Phase 2 7439-89-6 23925
5
Pramipexole Approved, Investigational Phase 4,Phase 3,Phase 2 104632-26-0 59868 119570
6
Ropinirole Approved, Investigational Phase 4,Phase 1 91374-20-8, 91374-21-9 5095 497540
7 tannic acid Approved, Nutraceutical Phase 4,Phase 3
8 Analgesics Phase 4,Phase 3
9 calcium channel blockers Phase 4,Phase 3
10 Dopamine agonists Phase 4,Phase 3,Phase 2,Phase 1
11 N 0437 Phase 4,Phase 3
12 GABA Agents Phase 4,Phase 3
13 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
14 Tranquilizing Agents Phase 4,Phase 3
15 Peripheral Nervous System Agents Phase 4,Phase 3
16 Dopamine Agents Phase 4,Phase 3,Phase 2,Phase 1
17 Anti-Anxiety Agents Phase 4,Phase 3
18
gamma-Aminobutyric Acid Phase 4,Phase 3 56-12-2 119
19 Excitatory Amino Acid Antagonists Phase 4,Phase 3
20 Excitatory Amino Acids Phase 4,Phase 3
21 Anticonvulsants Phase 4,Phase 3
22 Psychotropic Drugs Phase 4,Phase 3
23 Antimanic Agents Phase 4,Phase 3
24 Calcium, Dietary Phase 4,Phase 3
25 Antiparkinson Agents Phase 4,Phase 3,Phase 2,Phase 1
26 Central Nervous System Depressants Phase 4,Phase 3
27 Natriuretic Agents Phase 4
28 Coagulants Phase 4
29 Hematinics Phase 4,Phase 2
30 Hemostatics Phase 4
31 Deamino Arginine Vasopressin Phase 4
32 Trace Elements Phase 4,Phase 2
33 Vasopressins Phase 4
34 Ferric Compounds Phase 4,Phase 2
35 Arginine Vasopressin Phase 4
36 Micronutrients Phase 4,Phase 2
37 arginine Nutraceutical Phase 4
38
Levodopa Approved Phase 3 59-92-7 6047
39
Pregabalin Approved, Illicit, Investigational Phase 3 148553-50-8 5486971
40
Caffeine Approved, Nutraceutical Phase 3 58-08-2 2519
41 Benserazide Phase 3
42 Phosphodiesterase Inhibitors Phase 3
43 Protective Agents Phase 3,Phase 2
44 Purinergic P1 Receptor Antagonists Phase 3
45 Autonomic Agents Phase 3
46 Benserazide, levodopa drug combination Phase 3
47 Caffeine citrate Phase 3
48 Antioxidants Phase 3,Phase 2
49 Central Nervous System Stimulants Phase 3
50 Citrate Nutraceutical Phase 3

Interventional clinical trials:

(show all 35)
id Name Status NCT ID Phase
1 Effect of Rotigotine Patch Treatment on Cardiovascular Markers in Idiopathic Restless Legs Syndrome Unknown status NCT01823770 Phase 4
2 Effects of Gabapentin Enacarbil on Arousals, Heart Rate, Blood Pressure and PLMs in Restless Legs Syndrome Unknown status NCT02424695 Phase 4
3 Desmopressin Melt: Impact on Sleep and Daytime Functioning Completed NCT01645475 Phase 4
4 Effects of Neupro on Cardiovascular Observations in Patients With Restless Legs Syndrome Completed NCT01455012 Phase 4
5 12-week Polysomnography Study of Ropinirole Controlled Release for Restless Legs Syndrome Completed NCT00373542 Phase 4
6 Restless Legs Syndrome With Iron Deficiency or Anaemia in the 3rd Trimester of Pregnancy Completed NCT01245777 Phase 4
7 Butrans for Treatment of Restless Legs Syndrome Withdrawn NCT02138357 Phase 4
8 A Sleep Laboratory Study to Investigate the Safety and Efficacy of the Rotigotine Skin Patch in Subjects With Restless Legs Syndrome and End-Stage Renal Disease Requiring Hemodialysis Completed NCT01537042 Phase 3
9 Caffeine for Apnea of Prematurity-Sleep (CAP-S) Study Completed NCT01020357 Phase 3
10 A Sleep Lab Trial to Investigate the Efficacy and Safety of Transdermal Rotigotine in Subjects With Idiopathic Restless Legs Syndrome Completed NCT00275236 Phase 3
11 Assess Efficacy and Safety of the Dopamine Agonist Pramipexole Versus Levodopa / Benserazide (Madopar® DR) in Patients With Restless Legs Syndrome Completed NCT00144209 Phase 3
12 Polysomnography Study of GSK1838262 Extended Release Tablets Versus Placebo in RLS and Associated Sleep Disturbance Completed NCT00748098 Phase 3
13 Polysomnography Study Of Pregabalin And Pramipexole Versus Placebo In Patients With Restless Legs Syndrome And Associated Sleep Disturbance Completed NCT00991276 Phase 3
14 Rotigotine Effect on All-day Functioning and Quality of Life in Subjects With Moderate to Severe Restless Legs Syndrome (RLS) Completed NCT01569464 Phase 3
15 The Effects of Aplindore on the Treatment of Signs and Symptoms of Restless Legs Syndrome Completed NCT00626418 Phase 2
16 Pramipexole (BI-Sifrol®) Orally Once Daily for 6 Weeks in Patients With Primary Restless Legs Syndrome Completed NCT00152997 Phase 2
17 Dose Finding Study of Pramipexole (Sifrol) in Patients With Idiopathic Restless Legs Syndrome (RLS) Completed NCT00239486 Phase 2
18 Iron Sucrose In The Treatment of Restless Legs Syndrome: Safety of Three Dose Regimens as Evaluated by Clinical Assessments Completed NCT00895232 Phase 2
19 Iron Treatment of Sleep Disorders in Children With Autism Spectrum Disorder Terminated NCT01745497 Phase 2
20 Ropinirole Tablets In Young Patients With Restless Legs Syndrome Completed NCT00140712 Phase 1
21 Verification of Computerized Sleep-wake Analysis in Sleep Disorders Unknown status NCT02412527
22 Impact of Different Dialysis on Sleep Apnea in Patients With Renal Failure Unknown status NCT00380848
23 Effect of Intermittent Hemodialysis on Sleep Apnea Syndrome in End Stage Renal Disease Patients Completed NCT01860209
24 Dopamine Transporter Density Profiles in Patients With Periodic Limb Movements Completed NCT01365364
25 Effect of Ropinirole on Spinal Cord Reflexes and Restless Legs Syndrome Completed NCT00051961
26 The Study of Spectrum of Sleep Disorders in Cirrhotic Patients and the Efficacy of Zolpidem in Cirrhotic Patients With Insomnia Completed NCT02484963
27 Cervical Activation During Elastic and Manual Resistance Completed NCT02124304
28 A Study of Sleep Patterns in Patients Performing Nocturnal Home Dialysis Utilising the VIVIA System Recruiting NCT02583347
29 Effect of Beginning a Renal Replacement Therapy on Obstructive Sleep Apnea in End Stage Renal Disease Patients Recruiting NCT02073344
30 Effect of Renal Transplantation on Obstructive Sleep Apnea in End Stage Renal Disease Patients (SASinTx) Recruiting NCT02020642
31 Do Sleep and Circadian Rhythm Disturbances Impact the Cognitive and Behavioural Development of Children With Autism? Recruiting NCT02878499
32 Infra-slow Oscillations During Sleep Recruiting NCT02532608
33 Exploring the Use of Non-invasive Neuromodulation Combined With Exercise in People With Advanced Multiple Sclerosis (MS) Active, not recruiting NCT02252666
34 Cardiovascular Health Program Registry Enrolling by invitation NCT01975181
35 Analysis of Sympathetic Activity in Willis-Ekbom Disease Not yet recruiting NCT02929732

Search NIH Clinical Center for Periodic Limb Movement Disorder

Cochrane evidence based reviews: nocturnal myoclonus syndrome

Genetic Tests for Periodic Limb Movement Disorder

Anatomical Context for Periodic Limb Movement Disorder

MalaCards organs/tissues related to Periodic Limb Movement Disorder:

39
Testes, Brain, Globus Pallidus

Publications for Periodic Limb Movement Disorder

Articles related to Periodic Limb Movement Disorder:

(show top 50) (show all 71)
id Title Authors Year
1
Outcomes of long-term iron supplementation in pediatric restless legs syndrome/periodic limb movement disorder (RLS/PLMD). ( 27282843 )
2016
2
Obstructive sleep apnea and periodic limb movement disorder in a population of children with hypertension and/or nocturnal nondipping blood pressures. ( 26725017 )
2016
3
Rotigotine effect on sleep in a de novo Parkinson's Disease patient affected by periodic limb movement disorder. ( 26578038 )
2015
4
Topiramate-induced periodic limb movement disorder in a patient affected by focal epilepsy. ( 25667887 )
2014
5
Relationship between hepcidin levels and periodic limb movement disorder in patients with obstructive sleep apnea syndrome. ( 25008988 )
2014
6
The validity of the PAM-RL device for evaluating periodic limb movements in sleep and an investigation on night-to-night variability of periodic limb movements during sleep in patients with restless legs syndrome or periodic limb movement disorder using this system. ( 24269130 )
2014
7
Night-to-night variability of periodic leg movements during sleep in restless legs syndrome and periodic limb movement disorder: comparison between the periodicity index and the PLMS index. ( 23068780 )
2013
8
Treatment of childhood-onset restless legs syndrome and periodic limb movement disorder using intravenous iron sucrose. ( 23993871 )
2013
9
Bilateral globus pallidus internus deep brain stimulation in Parkinson's disease with periodic limb movement disorder. ( 23344876 )
2013
10
Migraine and periodic limb movement disorders in sleep in children: a preliminary case-control study. ( 23815623 )
2013
11
The treatment of restless legs syndrome and periodic limb movement disorder in adults-an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses: an American Academy of Sleep Medicine Clinical Practice Guideline. ( 22851801 )
2012
12
Impaired driving simulation in patients with Periodic Limb Movement Disorder and patients with Obstructive Sleep Apnea Syndrome. ( 22353445 )
2012
13
Clinical Inquiry. What drugs are effective for periodic limb movement disorder? ( 22577635 )
2012
14
Update to the AASM Clinical Practice Guideline: "The treatment of restless legs syndrome and periodic limb movement disorder in adults-an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses". ( 22851800 )
2012
15
Pediatric periodic limb movement disorder: sleep symptom and polysomnographic correlates compared to obstructive sleep apnea. ( 22171198 )
2011
16
Restless legs syndrome, periodic leg movements, and periodic limb movement disorder in children. ( 21600344 )
2011
17
Ropinirole in restless legs syndrome and periodic limb movement disorder. ( 20421915 )
2010
18
All the wrong moves: a clinical review of restless legs syndrome, periodic limb movements of sleep and wake, and periodic limb movement disorder. ( 20488295 )
2010
19
Restless legs syndrome and periodic limb movements disorder in the pediatric population. ( 20859209 )
2010
20
Periodic leg movements during sleep and periodic limb movement disorder in patients presenting with unexplained insomnia. ( 19109055 )
2009
21
Parents of children with periodic limb movement disorder versus sleep-disordered breathing report greater daytime mood and behavior difficulties in their child: the importance of using ICSD-2nd Edition criteria to define a PLMD study group. ( 19568964 )
2009
22
Behavioral Sleep Medicine Interventions for Restless Legs Syndrome and Periodic Limb Movement Disorder. ( 20161553 )
2009
23
Pediatric restless legs syndrome and periodic limb movement disorder: parent-child pairs. ( 19332386 )
2009
24
Restless legs syndrome and periodic limb movement disorder in children and adolescents. ( 18555195 )
2008
25
Periodic limb movements in sleep and periodic limb movement disorder. ( 17235435 )
2007
26
Selected sleep disorders: restless legs syndrome and periodic limb movement disorder, sleep apnea syndrome, and narcolepsy. ( 17118276 )
2006
27
EFNS guidelines on management of restless legs syndrome and periodic limb movement disorder in sleep. ( 16987157 )
2006
28
Periodic limb movement disorder in children. ( 16798596 )
2006
29
Periodic leg movements in sleep and periodic limb movement disorder: prevalence, clinical significance and treatment. ( 16762807 )
2006
30
Abnormal H-reflexes in periodic limb movement disorder; impact on understanding the pathophysiology of the disorder. ( 15589198 )
2005
31
Periodic limb movement disorder: an unusual mechanism of twiddling and potential benefit from cardiac resynchronization therapy. ( 15733189 )
2005
32
The restless legs syndrome and periodic limb movement disorder: a review of management. ( 15449218 )
2004
33
An update on the dopaminergic treatment of restless legs syndrome and periodic limb movement disorder. ( 15164915 )
2004
34
Activity patterns of leg muscles in periodic limb movement disorder. ( 14742617 )
2004
35
Practice parameters for the dopaminergic treatment of restless legs syndrome and periodic limb movement disorder. ( 15164914 )
2004
36
Restless legs syndrome and periodic limb movement disorder in the elderly. ( 15172211 )
2004
37
Periodic limb movement disorder and restless legs syndrome in dialysis patients. ( 15663636 )
2004
38
Restless legs syndrome and periodic limb movement disorder. ( 15087209 )
2004
39
SLEEP year in review 2003--insomnia, sleep in psychiatric disorders, periodic limb movement disorder/restless legs syndrome, sleep in medical disorders. ( 15532215 )
2004
40
The KickStrip: a novel testing device for periodic limb movement disorder. ( 12841376 )
2003
41
Different sleep characteristics in restless legs syndrome and periodic limb movement disorder. ( 14592346 )
2003
42
Can periodic limb movement disorder be diagnosed without polysomnography? A case-control study. ( 14592358 )
2003
43
Cognitive and behavioral anomalies among insomnia patients with mixed restless legs and periodic limb movement disorder. ( 15600136 )
2003
44
Periodic limb movement disorder of sleep in children. ( 12603789 )
2003
45
Prevalence of restless legs syndrome and periodic limb movement disorder in the general population. ( 12127170 )
2002
46
EEG mapping, psychometric, and polysomnographic studies in restless legs syndrome (RLS) and periodic limb movement disorder (PLMD) patients as compared with normal controls. ( 14592166 )
2002
47
Restless legs syndrome and periodic limb movement disorder. ( 12587366 )
2002
48
Clinical symptomatology and treatment of restless legs syndrome and periodic limb movement disorder. ( 12531131 )
2002
49
Subjective sleep quality and suggested immobilization test in restless leg syndrome and periodic limb movement disorder. ( 12047601 )
2002
50
Sleep laboratory studies in periodic limb movement disorder (PLMD) patients as compared with normals and acute effects of ropinirole. ( 12404588 )
2001

Variations for Periodic Limb Movement Disorder

Expression for Periodic Limb Movement Disorder

Search GEO for disease gene expression data for Periodic Limb Movement Disorder.

Pathways for Periodic Limb Movement Disorder

GO Terms for Periodic Limb Movement Disorder

Cellular components related to Periodic Limb Movement Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.17 DRD2 FXYD1 GLRA1 HTR1A HTR2A HTR2C

Biological processes related to Periodic Limb Movement Disorder according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.78 DRD2 HTR2A HTR2C SLC6A4
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.77 DRD2 HTR2A HTR2C
3 locomotory behavior GO:0007626 9.61 DRD2 HTR2C VPS13A
4 adult walking behavior GO:0007628 9.59 DRD2 GLRA1
5 behavioral fear response GO:0001662 9.58 HTR1A HTR2C
6 response to light stimulus GO:0009416 9.58 DRD2 PER1
7 regulation of dopamine secretion GO:0014059 9.57 DRD2 HTR2A
8 temperature homeostasis GO:0001659 9.56 DRD2 HTR2A
9 regulation of sodium ion transport GO:0002028 9.55 DRD2 PER1
10 behavioral response to cocaine GO:0048148 9.54 DRD2 HTR2A
11 response to iron ion GO:0010039 9.52 DRD2 HAMP
12 vasoconstriction GO:0042310 9.51 HTR1A SLC6A4
13 startle response GO:0001964 9.49 DRD2 GLRA1
14 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.46 DRD2 HTR2A
15 release of sequestered calcium ion into cytosol GO:0051209 9.43 DRD2 HTR2A HTR2C
16 regulation of behavior GO:0050795 9.4 HTR1A HTR2A
17 regulation of hormone secretion GO:0046883 9.37 HTR1A HTR2A
18 positive regulation of phosphatidylinositol biosynthetic process GO:0010513 9.32 HTR2A HTR2C
19 phospholipase C-activating serotonin receptor signaling pathway GO:0007208 9.16 HTR2A HTR2C
20 behavior GO:0007610 9.13 HTR1A HTR2A HTR2C
21 serotonin receptor signaling pathway GO:0007210 8.8 HTR1A HTR2A HTR2C

Molecular functions related to Periodic Limb Movement Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 signal transducer activity GO:0004871 9.67 DRD2 HTR1A HTR2A HTR2C
2 drug binding GO:0008144 9.5 DRD2 HTR2A HTR2C
3 G-protein coupled serotonin receptor activity GO:0004993 9.43 HTR1A HTR2A HTR2C
4 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding GO:0071886 9.16 HTR2A HTR2C
5 neurotransmitter receptor activity GO:0030594 9.13 HTR1A HTR2A HTR2C
6 serotonin binding GO:0051378 8.8 HTR1A HTR2A HTR2C

Sources for Periodic Limb Movement Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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