MCID: PRD002
MIFTS: 40

Periodic Limb Movement Disorder

Categories: Mental diseases

Aliases & Classifications for Periodic Limb Movement Disorder

MalaCards integrated aliases for Periodic Limb Movement Disorder:

Name: Periodic Limb Movement Disorder 12 72 51 14
Nocturnal Myoclonus Syndrome 41 69
Klp10a Protein, Drosophila 41
Nocturnal Myoclonus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9207
ICD10 32 G47.61
ICD9CM 34 327.51
MeSH 41 D020189
SNOMED-CT 64 418763003
UMLS 69 C0751774

Summaries for Periodic Limb Movement Disorder

Disease Ontology : 12 A sleep disorder that involves involuntary limb movement during sleep.

MalaCards based summary : Periodic Limb Movement Disorder, also known as nocturnal myoclonus syndrome, is related to apnea, obstructive sleep and narcolepsy. An important gene associated with Periodic Limb Movement Disorder is GLRA1 (Glycine Receptor Alpha 1), and among its related pathways/superpathways are cAMP signaling pathway and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Olive and Omega 3 Fatty Acid have been mentioned in the context of this disorder. Affiliated tissues include testes, globus pallidus and brain, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 72 Periodic limb movement disorder (PLMD), previously known as nocturnal myoclonus, is a sleep disorder... more...

Related Diseases for Periodic Limb Movement Disorder

Diseases related to Periodic Limb Movement Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 apnea, obstructive sleep 29.9 CTNNBL1 HTR2A
2 narcolepsy 29.7 CTNNBL1 DRD2 HTR2A
3 attention deficit-hyperactivity disorder 29.6 DRD2 HTR1A HTR2A HTR2C SLC6A4
4 migraine with or without aura 1 28.9 DRD2 HTR1A HTR2A HTR2C KANTR SLC6A4
5 restless legs syndrome 11.4
6 schizophrenia 5 10.4 HTR1A HTR2A
7 tardive dyskinesia 10.4 DRD2 HTR2A
8 schizoid personality disorder 10.4 HTR1A HTR2A
9 hypoactive sexual desire disorder 10.4 HTR1A HTR2A
10 substance-induced psychosis 10.4 HTR1A HTR2A
11 alcohol use disorder 10.4 DRD2 SLC6A4
12 alcohol-induced mental disorder 10.4 DRD2 SLC6A4
13 social phobia 10.4 DRD2 SLC6A4
14 alzheimer disease 5 10.4 HTR2A SLC6A4
15 neuroleptic malignant syndrome 10.3 DRD2 HTR1A
16 phobic disorder 10.3 HTR1A SLC6A4
17 kleptomania 10.3 HTR1A SLC6A4
18 dysthymic disorder 10.3 HTR2A SLC6A4
19 tic disorder 10.3 DRD2 HTR2A
20 oppositional defiant disorder 10.3 DRD2 SLC6A4
21 brunner syndrome 10.3 HTR1A SLC6A4
22 sleep apnea 10.3
23 drug-induced mental disorder 10.3 DRD2 HTR1A HTR2A
24 drug psychosis 10.3 DRD2 HTR1A HTR2A
25 alexithymia 10.2 DRD2 HTR1A SLC6A4
26 alcoholic psychosis 10.2 DRD2 HTR2A SLC6A4
27 bruxism 10.2 DRD2 HTR2A SLC6A4
28 migraine with aura 10.2 DRD2 HTR2C SLC6A4
29 eating disorder 10.2 DRD2 HTR2C SLC6A4
30 migraine without aura 10.2 DRD2 HTR1A SLC6A4
31 pathological gambling 10.2 DRD2 HTR2A SLC6A4
32 premature ejaculation 10.2 HTR1A HTR2C SLC6A4
33 early-onset schizophrenia 10.2 DRD2 HTR2A SLC6A4
34 intermittent explosive disorder 10.2 HTR1A SLC6A4
35 post-traumatic stress disorder 10.2 DRD2 HTR2A SLC6A4
36 schizoaffective disorder 10.2 DRD2 HTR2A SLC6A4
37 agoraphobia 10.2 HTR1A SLC6A4
38 cranio-facial dystonia 10.2 HTR2A KANTR
39 serotonin syndrome 10.2 HTR1A HTR2A SLC6A4
40 endogenous depression 10.2 HTR1A HTR2A SLC6A4
41 lymphedema, hereditary, ii 10.1 HTR2A KANTR
42 reunion island larsen syndrome 10.1
43 auditory agnosia 10.1 CTNNBL1 KANTR
44 myoclonus 10.0
45 antisocial personality disorder 10.0 DRD2 SLC6A4
46 generalized anxiety disorder 10.0 DRD2 HTR1A HTR2A SLC6A4
47 psychosexual disorder 10.0 HTR1A HTR2A HTR2C SLC6A4
48 restless legs syndrome 6 10.0
49 sleep disorder 10.0
50 borderline personality disorder 10.0 HTR1A HTR2A HTR2C SLC6A4

Graphical network of the top 20 diseases related to Periodic Limb Movement Disorder:



Diseases related to Periodic Limb Movement Disorder

Symptoms & Phenotypes for Periodic Limb Movement Disorder

GenomeRNAi Phenotypes related to Periodic Limb Movement Disorder according to GeneCards Suite gene sharing:

25 (show all 27)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.84 FXYD1 HTR2C
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.84 HTR2C
3 Increased shRNA abundance (Z-score > 2) GR00366-A-106 9.84 HTR2C
4 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.84 HTR2C SLC6A4 CTNNBL1 DRD2 FXYD1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.84 CTNNBL1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.84 FXYD1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.84 CTNNBL1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.84 DRD2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.84 CTNNBL1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.84 FXYD1 DRD2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.84 CTNNBL1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.84 SLC6A4
13 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.84 DRD2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.84 HTR2C
15 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.84 SLC6A4
16 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.84 FXYD1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.84 FXYD1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.84 CTNNBL1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.84 FXYD1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.84 DRD2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.84 DRD2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.84 SLC6A4
23 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.84 HTR2C
24 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.84 HTR2C
25 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.84 DRD2
26 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.84 SLC6A4
27 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.84 CTNNBL1

MGI Mouse Phenotypes related to Periodic Limb Movement Disorder:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.17 DRD2 FXYD1 GLRA1 HTR2A HTR2C SLC6A4

Drugs & Therapeutics for Periodic Limb Movement Disorder

Drugs for Periodic Limb Movement Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Olive Nutraceutical
2 Omega 3 Fatty Acid Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Intermittent Hemodialysis on Sleep Apnea Syndrome in End Stage Renal Disease Patients Completed NCT01860209
2 Sleep Disturbance in Patients With End-Stage Renal Disease Recruiting NCT02583347
3 Effect of Beginning a Renal Replacement Therapy on Obstructive Sleep Apnea in End Stage Renal Disease Patients Recruiting NCT02073344
4 Effect of Renal Transplantation on Obstructive Sleep Apnea in End Stage Renal Disease Patients (SASinTx) Recruiting NCT02020642
5 The Link Between Clinical and Physiological Sleep Data and Health-related Outcomes Recruiting NCT03383354
6 Cardiovascular Health Program Registry Enrolling by invitation NCT01975181

Search NIH Clinical Center for Periodic Limb Movement Disorder

Cochrane evidence based reviews: nocturnal myoclonus syndrome

Genetic Tests for Periodic Limb Movement Disorder

Anatomical Context for Periodic Limb Movement Disorder

MalaCards organs/tissues related to Periodic Limb Movement Disorder:

38
Testes, Globus Pallidus, Brain

Publications for Periodic Limb Movement Disorder

Articles related to Periodic Limb Movement Disorder:

(show top 50) (show all 75)
# Title Authors Year
1
Pharmacological Management of Restless Legs Syndrome and Periodic Limb Movement Disorder in Children. ( 28831753 )
2017
2
Periodic Limb Movements During Sleep Mimicking REM Sleep Behavior Disorder: A New Form of Periodic Limb Movement Disorder. ( 28364416 )
2017
3
Should oral iron be first-line therapy for pediatric restless legs syndrome and periodic limb movement disorder? ( 28279575 )
2017
4
While Isolated Periodic Limb Movement Disorder Significantly Impacts Sleep Depth and Efficiency, Co-Morbid Restless Leg Syndrome Mainly Exacerbates Perceived Sleep Quality. ( 28391285 )
2017
5
Obstructive sleep apnea and periodic limb movement disorder in a population of children with hypertension and/or nocturnal nondipping blood pressures. ( 26725017 )
2016
6
Outcomes of long-term iron supplementation in pediatric restless legs syndrome/periodic limb movement disorder (RLS/PLMD). ( 27282843 )
2016
7
Rotigotine effect on sleep in a de novo Parkinson's Disease patient affected by periodic limb movement disorder. ( 26578038 )
2015
8
Topiramate-induced periodic limb movement disorder in a patient affected by focal epilepsy. ( 25667887 )
2014
9
Relationship between hepcidin levels and periodic limb movement disorder in patients with obstructive sleep apnea syndrome. ( 25008988 )
2014
10
The validity of the PAM-RL device for evaluating periodic limb movements in sleep and an investigation on night-to-night variability of periodic limb movements during sleep in patients with restless legs syndrome or periodic limb movement disorder using this system. ( 24269130 )
2014
11
Treatment of childhood-onset restless legs syndrome and periodic limb movement disorder using intravenous iron sucrose. ( 23993871 )
2013
12
Night-to-night variability of periodic leg movements during sleep in restless legs syndrome and periodic limb movement disorder: comparison between the periodicity index and the PLMS index. ( 23068780 )
2013
13
Bilateral globus pallidus internus deep brain stimulation in Parkinson's disease with periodic limb movement disorder. ( 23344876 )
2013
14
Migraine and periodic limb movement disorders in sleep in children: a preliminary case-control study. ( 23815623 )
2013
15
The treatment of restless legs syndrome and periodic limb movement disorder in adults-an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses: an American Academy of Sleep Medicine Clinical Practice Guideline. ( 22851801 )
2012
16
Clinical Inquiry. What drugs are effective for periodic limb movement disorder? ( 22577635 )
2012
17
Impaired driving simulation in patients with Periodic Limb Movement Disorder and patients with Obstructive Sleep Apnea Syndrome. ( 22353445 )
2012
18
Update to the AASM Clinical Practice Guideline: "The treatment of restless legs syndrome and periodic limb movement disorder in adults-an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses". ( 22851800 )
2012
19
Pediatric periodic limb movement disorder: sleep symptom and polysomnographic correlates compared to obstructive sleep apnea. ( 22171198 )
2011
20
Restless legs syndrome, periodic leg movements, and periodic limb movement disorder in children. ( 21600344 )
2011
21
Restless legs syndrome and periodic limb movements disorder in the pediatric population. ( 20859209 )
2010
22
All the wrong moves: a clinical review of restless legs syndrome, periodic limb movements of sleep and wake, and periodic limb movement disorder. ( 20488295 )
2010
23
Ropinirole in restless legs syndrome and periodic limb movement disorder. ( 20421915 )
2010
24
Behavioral Sleep Medicine Interventions for Restless Legs Syndrome and Periodic Limb Movement Disorder. ( 20161553 )
2009
25
Pediatric restless legs syndrome and periodic limb movement disorder: parent-child pairs. ( 19332386 )
2009
26
Periodic leg movements during sleep and periodic limb movement disorder in patients presenting with unexplained insomnia. ( 19109055 )
2009
27
Parents of children with periodic limb movement disorder versus sleep-disordered breathing report greater daytime mood and behavior difficulties in their child: the importance of using ICSD-2nd Edition criteria to define a PLMD study group. ( 19568964 )
2009
28
Restless legs syndrome and periodic limb movement disorder in children and adolescents. ( 18555195 )
2008
29
Periodic limb movements in sleep and periodic limb movement disorder. ( 17235435 )
2007
30
Periodic limb movement disorder in children. ( 16798596 )
2006
31
EFNS guidelines on management of restless legs syndrome and periodic limb movement disorder in sleep. ( 16987157 )
2006
32
Periodic leg movements in sleep and periodic limb movement disorder: prevalence, clinical significance and treatment. ( 16762807 )
2006
33
Selected sleep disorders: restless legs syndrome and periodic limb movement disorder, sleep apnea syndrome, and narcolepsy. ( 17118276 )
2006
34
Periodic limb movement disorder: an unusual mechanism of twiddling and potential benefit from cardiac resynchronization therapy. ( 15733189 )
2005
35
Abnormal H-reflexes in periodic limb movement disorder; impact on understanding the pathophysiology of the disorder. ( 15589198 )
2005
36
Periodic limb movement disorder and restless legs syndrome in dialysis patients. ( 15663636 )
2004
37
The restless legs syndrome and periodic limb movement disorder: a review of management. ( 15449218 )
2004
38
SLEEP year in review 2003--insomnia, sleep in psychiatric disorders, periodic limb movement disorder/restless legs syndrome, sleep in medical disorders. ( 15532215 )
2004
39
Restless legs syndrome and periodic limb movement disorder in the elderly. ( 15172211 )
2004
40
Restless legs syndrome and periodic limb movement disorder. ( 15087209 )
2004
41
An update on the dopaminergic treatment of restless legs syndrome and periodic limb movement disorder. ( 15164915 )
2004
42
Practice parameters for the dopaminergic treatment of restless legs syndrome and periodic limb movement disorder. ( 15164914 )
2004
43
Activity patterns of leg muscles in periodic limb movement disorder. ( 14742617 )
2004
44
Can periodic limb movement disorder be diagnosed without polysomnography? A case-control study. ( 14592358 )
2003
45
Different sleep characteristics in restless legs syndrome and periodic limb movement disorder. ( 14592346 )
2003
46
The KickStrip: a novel testing device for periodic limb movement disorder. ( 12841376 )
2003
47
Periodic limb movement disorder of sleep in children. ( 12603789 )
2003
48
Cognitive and behavioral anomalies among insomnia patients with mixed restless legs and periodic limb movement disorder. ( 15600136 )
2003
49
Subjective sleep quality and suggested immobilization test in restless leg syndrome and periodic limb movement disorder. ( 12047601 )
2002
50
Clinical symptomatology and treatment of restless legs syndrome and periodic limb movement disorder. ( 12531131 )
2002

Variations for Periodic Limb Movement Disorder

Expression for Periodic Limb Movement Disorder

Search GEO for disease gene expression data for Periodic Limb Movement Disorder.

Pathways for Periodic Limb Movement Disorder

GO Terms for Periodic Limb Movement Disorder

Cellular components related to Periodic Limb Movement Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.17 DRD2 FXYD1 GLRA1 HTR1A HTR2A HTR2C

Biological processes related to Periodic Limb Movement Disorder according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.77 DRD2 HTR2A HTR2C
2 response to drug GO:0042493 9.73 DRD2 HTR2A HTR2C SLC6A4
3 adult walking behavior GO:0007628 9.59 DRD2 GLRA1
4 behavioral fear response GO:0001662 9.58 HTR1A HTR2C
5 response to light stimulus GO:0009416 9.58 DRD2 PER1
6 regulation of dopamine secretion GO:0014059 9.57 DRD2 HTR2A
7 behavioral response to cocaine GO:0048148 9.56 DRD2 HTR2A
8 temperature homeostasis GO:0001659 9.55 DRD2 HTR2A
9 G-protein coupled serotonin receptor signaling pathway GO:0098664 9.54 HTR1A HTR2A
10 response to iron ion GO:0010039 9.52 DRD2 HAMP
11 regulation of sodium ion transport GO:0002028 9.51 DRD2 PER1
12 vasoconstriction GO:0042310 9.49 HTR1A SLC6A4
13 startle response GO:0001964 9.48 DRD2 GLRA1
14 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.46 DRD2 HTR2A
15 release of sequestered calcium ion into cytosol GO:0051209 9.43 DRD2 HTR2A HTR2C
16 regulation of behavior GO:0050795 9.4 HTR1A HTR2A
17 regulation of hormone secretion GO:0046883 9.37 HTR1A HTR2A
18 positive regulation of phosphatidylinositol biosynthetic process GO:0010513 9.32 HTR2A HTR2C
19 phospholipase C-activating serotonin receptor signaling pathway GO:0007208 9.16 HTR2A HTR2C
20 behavior GO:0007610 9.13 HTR1A HTR2A HTR2C
21 serotonin receptor signaling pathway GO:0007210 8.8 HTR1A HTR2A HTR2C

Molecular functions related to Periodic Limb Movement Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transducer activity GO:0004871 9.67 DRD2 HTR1A HTR2A HTR2C
2 drug binding GO:0008144 9.5 DRD2 HTR2A HTR2C
3 neurotransmitter receptor activity GO:0030594 9.33 HTR1A HTR2A HTR2C
4 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding GO:0071886 9.26 HTR2A HTR2C
5 G-protein coupled serotonin receptor activity GO:0004993 9.13 HTR1A HTR2A HTR2C
6 serotonin binding GO:0051378 8.8 HTR1A HTR2A HTR2C

Sources for Periodic Limb Movement Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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