Periodontal Disease malady

Wikipedia: Periodontal disease is a type of disease that affects one or more of the periodontal tissues:⁴⁴ more...

MalaCards: Periodontal Disease, also known as periodontal diseases, is related to periodontitis and arthritis. An important gene associated with Periodontal Disease is MMP8 (matrix metallopeptidase 8 (neutrophil collagenase)), and among its related pathways are Activation of Matrix Metalloproteinases and Inhibition of Matrix Metalloproteinases. The drugs chlorhexidine and chlorhexidine gluconate and the compounds glyceraldehyde 3-phosphate and hcec have been mentioned in the context of this disorder. Affiliated tissues include whole blood, heart and kidney, and related mouse phenotypes are respiratory system and renal/urinary system.

Aliases & Descriptions:

periodontal disease 6 8 periodontal diseases 32 43 disease of supporting structures of teeth, nos 6

periodontal disease (disorder) 6 periodontium disorder 6

Diseases related to periodontal disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 939)

id	Related Disease	Score	Top Affiliating Genes
1	periodontitis	41.5	BSG, VDR, LBP, MPO, CD36, CD14
2	arthritis	32.6	MMP3, IL17A, IL1A, IL1B, IL6, IL8
3	hypophosphatasia	30.8	IL1R1, ALPL, ALPP, ALPPL2, CALCA, DSPP
4	severe congenital neutropenia	29.6	CD14, GUSB, FCGR3A, IL8, CAMP, TNF
5	dental caries	29.4	CD79A, MMP8, FGF10, ALB, HLA-DQB1, CRP
6	gingivitis	29.2	SELE, SERPINF2, SERPINB2, BSG, VEGFA, BMP6
7	cadasil	28.8	COG2, SERPINF2, BSG, SAA4, S100A8, CD14
8	aggressive periodontitis	28.2	SELE, VEGFA, VDR, S100A8, MPO, CD79A
9	severe pre-eclampsia	27.3	VEGFA, FN1, FGR, IL1B, GPT, ALB
10	pre-eclampsia	26.3	SELE, SERPINF2, SERPINB2, VEGFA, LDHA, S100A8
11	neutropenia	25.3	LBP, LACTB, MPO, CD79A, CD14, CD40LG
12	sjogren's syndrome	24.4	SELE, S100A8, S100A9, CD79A, CD86, CD4
13	down syndrome	22.2	VEGFA, BMP6, MPO, CD79A, CD36, CD40LG
14	coronary heart disease	22.1	COG2, SELE, SERPINF2, VEGFA, BGLAP, CHKB
15	eclampsia	20.7	SELE, SERPINB2, VEGFA, BMP6, LDHA, MPO
16	diabetes mellitus	20.4	COG2, SELE, SERPINF2, NAT2, VEGFA, VDR
17	rheumatoid arthritis	19.6	SELE, SERPINF2, SERPINB2, BSG, NAT2, VEGFA
18	acute myocardial infarction	19.2	COG2, SELE, SERPINF2, BSG, VEGFA, CHKB
19	insulin resistance	19.1	COG2, SELE, VEGFA, VDR, BMP6, BGLAP
20	myocardial infarction	18.7	COG2, SELE, SERPINF2, SERPINB2, BSG, VEGFA
21	atherosclerosis	18.6	COG2, SELE, SERPINF2, SERPINB2, BSG, NAT2
22	prostatitis	17.7	SELE, SERPINF2, SERPINB2, BSG, NAT2, VEGFA
23	refractive error	14.5	MMP1, MMP13, MMP14, MMP2, MMP3, MMP7
24	joint disorders	14.5	SERPINB2, MMP3, IL11, IL1R1, IL1R2, IL1RAPL2
25	abdominal aortic aneurysm	14.4	MMP1, MMP13, MMP14, MMP2, MMP3, MMP8
26	diffuse panbronchiolitis	14.4	MPO, CD79A, IL1B, IL1RAPL2, IL1RN, IL8
27	panbronchiolitis	14.4	MPO, CD79A, IL1B, IL1RAPL2, IL1RN, IL8
28	villonodular synovitis	14.4	BGLAP, MMP1, MMP9, IBSP, TNFRSF11B, TNFSF11
29	chronic venous leg ulcers	14.3	BSG, MMP1, MMP2, MMP3, MMP9, TNF
30	conjunctivochalasis	14.3	MMP1, MMP2, MMP3, MMP9, IL6, IL8
31	pigmented villonodular synovitis	14.3	BGLAP, MMP1, MMP9, IBSP, TNFRSF11B, TNFSF11
32	osteoporosis, postmenopausal	14.3	VDR, BGLAP, CD36, IL11, IL1RAPL2, IL1RN
33	reactive arthritis	14.3	BSG, BPI, LBP, CD79A, MMP8, HSPD1
34	root resorption	14.3	MMP9, IL1A, IL1B, AMELX, AMELY, CALCA
35	ankylosing spondylitis	14.3	BGLAP, CD79A, CD40LG, MMP3, IL17A, IL1R1
36	nephropathia epidemica	14.3	IL1A, IL1B, IL1RN, IL6, TNF, CRP
37	oral candidiasis	14.3	MPO, HTN3, LTF, DEFB1, DEFB4A, DEFB103B
38	bacterial meningitis	14.3	LBP, LACTB, MMP8, GUSB, IL1B, IL8
39	spondylarthropathy	14.3	S100A8, S100A9, IL1RAPL2, TNF, CRP, TLR4
40	chronic infantile neurological cutaneous articular syndrome	14.3	IL18, IL1B, IL1R1, IL1RAPL2, IL1RN, PYCARD
41	paget's disease of bone	14.3	VDR, BGLAP, PAX5, CD36, IL1B, IL1R1
42	benign tumors	14.2	BSG, ITGB1, MMP13, MMP14, GUSB, MAPK1
43	fibrous dysplasia	14.2	BGLAP, CD36, IL6, IBSP, ALPL, ALPP
44	renal osteodystrophy	14.2	VDR, BGLAP, CD36, IL11, IL6, ALPL
45	bone cancer	14.2	VDR, CD36, IL1B, IL1RAPL2, IL1RN, ALPL
46	osteogenesis imperfecta	14.2	BGLAP, CD36, IBSP, ALPL, ALPP, ALPPL2
47	pulpitis	14.2	MMP1, IL1A, IL8, CALCA, TNF, TIMP1
48	giant cell tumor	14.2	BGLAP, MMP9, CALCA, TNFRSF11A, TNFRSF11B, TNFSF11
49	schnitzler syndrome	14.2	CD40LG, IL18, IL1A, IL1R1, IL1RAPL2, IL1RN
50	muckle-wells syndrome	14.2	IL1B, IL1R1, IL1RAPL2, IL8, CRP, NLRP3

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 chlorhexidine, chlorhexidine gluconate

MalaCards organs/tissues related to periodontal disease:

²²

MGI Mouse Phenotypes related to periodontal disease:

²⁵ (show all 24)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.4	LDHA, JMJD6, CD14, IL12A, IL12B, IL17F
2	renal/urinary system phenotype	MP:0005367	10.2	LAMC2, JMJD6, ITGB1, MMP14, INS, FGF10
3	immune system phenotype	MP:0005387	10.0	SERPINB2, BSG, VDR, PAX5, LDHA, LBP
4	endocrine/exocrine gland phenotype	MP:0005379	10.0	CD40LG, GUSB, FGF10, IFNG, PYCARD, CTLA4
5	craniofacial phenotype	MP:0005382	10.0	JMJD6, GUSB, FGF10, IL12B, IL17A, IL17F
6	limbs/digits/tail phenotype	MP:0005371	9.8	VEGFA, VDR, CHKB, LAMC2, CD44, ITGB1
7	other phenotype	MP:0005395	9.7	LAMC2, CD40LG, ITGB1, MMP14, FN1, ALPL
8	skeleton phenotype	MP:0005390	9.4	VEGFA, VDR, BMP6, LAMC2, CD14, CD44
9	hematopoietic system phenotype	MP:0005397	9.3	SERPINB2, LDHA, CD86, IRAK3, IL12B, IL12RB2
10	integument phenotype	MP:0010771	8.6	LAMC2, JMJD6, CD4, CD44, ITGB1, MMP13
11	reproductive system phenotype	MP:0005389	8.5	VEGFA, VDR, CD44, ITGB1, MMP14, MMP9
12	liver/biliary system phenotype	MP:0005370	8.3	VEGFA, LBP, JMJD6, CD36, INS, IL12RB2
13	nervous system phenotype	MP:0003631	8.1	PAX5, CHKB, JMJD6, CD36, CD86, CD4
14	behavior/neurological phenotype	MP:0005386	7.9	SELE, PAX5, CHKB, LAMC2, CD86, CD44
15	tumorigenesis	MP:0002006	7.9	LDHA, CD44, ITGB1, MMP2, MMP7, MMP8
16	growth/size phenotype	MP:0005378	7.8	SELE, SERPINB2, BSG, VDR, BMP6, PAX5
17	mortality/aging	MP:0010768	7.7	SELE, SERPINB2, BSG, VEGFA, VDR, PAX5
18	normal phenotype	MP:0002873	7.6	SELE, VEGFA, PAX5, LDHA, CD79A, CD4
19	digestive/alimentary phenotype	MP:0005381	7.2	VEGFA, VDR, LAMC2, JMJD6, CD36, CD4
20	muscle phenotype	MP:0005369	6.3	SERPINB2, VEGFA, CHKB, MPO, JMJD6, CD36
21	homeostasis/metabolism phenotype	MP:0005376	5.2	SELE, SERPINF2, SERPINB2, NAT2, VEGFA, VDR
22	vision/eye phenotype	MP:0005391	5.1	SELE, VEGFA, JMJD6, CD36, CD44, ITGB1
23	cardiovascular system phenotype	MP:0005385	4.8	SELE, VEGFA, VDR, LDHA, MPO, JMJD6
24	cellular phenotype	MP:0005384	3.8	SELE, VEGFA, VDR, PAX5, S100A9, JMJD6

Articles related to periodontal disease:

(show top 50)    (show all 271)

id	Title	Authors	Year	Affiliating Genes
1	Identification of pathogen and host-response markers correlated with periodontal disease. (19254128)	Ramseier C.A.... Giannobile W.V.	2009	TNFRSF11B
2	Activation of cyclic AMP response element-binding pro tein (CREB) in aggressive periodontal disease. (19898718)	Buchmann R.... Sculean A.	2009	CREB1
3	Up-regulation of the endoplasmic reticulum stress-response in periodontal disease. (19109937)	Domon H.... Yamazaki K.	2009	HSPD1
4	B cells from periodontal disease patients express surface Toll-like receptor 4. (19118102)	Shin H.... Nikolajczyk B.S.	2009	TLR4
5	Polymorphism of genes encoding toll-like receptors and inflammatory cytokines in periodontal disease in the Japanese population. (18714935)	Imamura Y.... Wang P.L.	2008	IL1B, TLR2, TLR4
6	Polymorphisms in the 5' flanking region of IL12RB2 are associated with susceptibility to periodontal diseases in the Japanese population. (18353079)	Takeuchi-Hatanaka K.... Takashiba S.	2008	IL12RB2
7	Stromal-derived factor-1alpha (CXCL12) levels increase in periodontal disease. (18454663)	Havens A.M.... Taichman R.S.	2008	CXCL12
8	Interleukin-4, a T-helper 2 cell cytokine, is associated with the remission of periodontal disease. (18624944)	Pradeep A.R.... Swati P.P.	2008	IL4
9	Bone remodeling biomarkers of periodontal disease in saliva. (18834246)	Frodge B.D.... Miller C.S.	2008	TNF, TNFSF11, CD36
10	Interactions between chronic renal disease and periodontal disease. (18173441)	Craig R.G.	2008	CRP
11	Interleukin-11, interleukin-1beta, interleukin-12 and the pathogenesis of inflammatory periodontal diseases. (18433382)	Yucel O.O.... Otlu H.	2008	IL1B, IL11
12	Lack of association between the TNF-alpha -308 (G/A) genetic polymorphism and periodontal disease in Brazilians. (19148387)	Menezes N.G.... Colombo A.P.	2008	TNF
13	A trend of increase in periodontal interleukin-6 expression across patients with neither diabetes nor periodontal disease, patients with periodontal disease alone, and patients with both diseases. (18627438)	Cole C.M.... Huang Y.	2008	MMP8, MMP1, IL6
14	Total antioxidant capacity and antioxidant enzymes in serum, saliva, and gingival crevicular fluid of preeclamptic women with and without periodontal disease. (17668980)	Canakci V.... Canakci H.	2007	SOD1
15	Interleukin 18 and periodontal disease. (17586702)	Orozco A.... Seymour G.J.	2007	IL18
16	Gingival crevicular fluid matrix metalloproteinase (MMP)-7, extracellular MMP inducer, and tissue inhibitor of MMP-1 levels in periodontal disease. (17209789)	Emingil G.... Atilla G.	2006	MMP7, MMP1, TIMP1
17	Gingival crevicular fluid matrix metalloproteinase-13 levels and molecular forms in various types of periodontal diseases. (17054770)	Ilgenli T.... Atilla G.	2006	MMP13
18	Studies on periodontitis and analyses of individuals at risk for periodontal diseases. (16838563)	Jansson H.	2006	IL6, IL1A
19	Secretory function of neutrophilic leukocytes of the patients with periodontal diseases. (16340274)	Sakalauskiene J.... Gleiznys A.	2005	GUSB
20	Demonstration of factor H-like protein 1 binding to Treponema denticola, a pathogen associated with periodontal disease in humans. (16239506)	McDowell J.V.... Marconi R.T.	2005	CFHR1
21	Relationship between periodontal disease status and combination of biochemical assays of gingival crevicular fluid. (15966911)	Hanioka T.... Shizukuishi S.	2005	ELANE, CD79A
22	Is periodontal disease mediated by salivary BAFF in Sjogren's syndrome? (16052575)	Pers J.O.... Youinou P.	2005	TNFSF13B
23	The immune responses to human and microbial heat shock proteins in periodontal disease with and without coronary heart disease. (16297172)	Hasan A.... Lehner T.	2005	HSPD1
24	Lack of association between the TNF alpha G -308 A promoter polymorphism and periodontal disease. (15142214)	Folwaczny M.... Folwaczny C.	2004	TNF
25	An investigation into the association among preterm birth, cytokine gene polymorphisms and periodontal disease. (14723749)	Moore S.... Simpson N.A.	2004	TNF, IL1B
26	The CD14 -159C-to-T promoter polymorphism in periodontal disease. (15491315)	Folwaczny M.... Folwaczny C.	2004	CD14
27	Periodontal disease and diabetes mellitus: the role of tumor necrosis factor-alpha in a 2-way relationship. (12593603)	Nishimura F.... Murayama Y.	2003	TNF
28	Patterns of chemokines and chemokine receptors expression in different forms of human periodontal disease. (12608917)	Garlet G.P.... Silva J.S.	2003	CCL2, IL10
29	The secretion of prostaglandin E2 and interleukin 1-beta in women with periodontal diseases and preterm low-birth-weight. (14535055)	Konopka T.... Karolewska E.	2003	IL1B
30	The interleukin-1 polymorphism, smoking, and the risk of periodontal disease in the population-based SHIP study. (12598547)	Meisel P.... Kocher T.	2003	IL1B, IL1A
31	Oral treatment with SRP299 (killed Mycobacterium vaccae) inhibits experimental periodontal disease in Wistar rats. (14761113)	Breivik T.... Rook G.A.	2003	TNF
32	Infectious complications of dental and periodontal diseases in the elderly population. (11941548)	Shay K.	2002	DSPP
33	Association between bone loss in periodontal disease and polymorphism of N-acetyltransferase (NAT2). (11846845)	Kocher T.... Meisel P.	2002	NAT2
34	Smoking and polymorphisms of the interleukin-1 gene cluster (IL-1alpha, IL-1beta, and IL-1RN) in patients with periodontal disease. (11846196)	Meisel P.... Kocher T.	2002	IL1B, IL1R1, IL1A
35	Importance of periodontal disease in the kidney patie nt. (11803168)	Craig R.G.... Levin N.W.	2002	CRP
36	Relationship between crevicular aspartate aminotransferase levels and periodontal disease progression. (11210069)	Oringer R.J.... Fiorellini J.P.	2001	SLC17A5
37	Involvement of T-lymphocytes in periodontal disease and in direct and indirect induction of bone resorption. (11345523)	Taubman M.A.... Kawai T.	2001	CXCR3
38	Association of vitamin D receptor gene polymorphism with periodontal diseases in Japanese and Chinese. (12836289)	Tachi Y.... Cao C.	2001	VDR
39	Alanine aminopeptidase and dipeptidylpeptidase IV in saliva: the possible role in periodontal disease. (10876015)	ElgA1n S.... DemirtaA9 S.	2000	DPP4
40	Acute-phase inflammatory response to periodontal disease in the US population. (10690660)	Slade G.D.... Pankow J.S.	2000	CRP
41	The role of IL-6 in the pathogenesis of periodontal disease. (9655045)	Irwin C.R.... Myrillas T.T.	1998	TNF, IL6, IL1B
42	Hyporesponsiveness of inflamed human gingival fibroblasts from patients with chronic periodontal diseases against cell surface components of Porphyromonas gingivalis. (9215583)	Ogawa T.... Uchida H.	1997	IL8
43	Expression of T-cell receptor Vbeta2, 6 and 8 gene families in chronic adult periodontal disease. (9395100)	Geatch D.R.... Taylor J.J.	1997	TRB@
44	Inflammatory mediator response as a potential risk marker for periodontal diseases in insulin-dependent diabetes mellitus patients. (9058329)	Salvi G.E.... Offenbacher S.	1997	IL1B
45	Medical status and complications in relation to periodontal disease experience in insulin-dependent diabetics. (8707978)	Thorstensson H.... Hugoson A.	1996	INS
46	The clinico-biochemical characteristics of periodontal diseases in subjects who are under conditions of constant, permanent stress (8658570)	Akopov S.E.... Sarkisian M.A.	1996	THBD
47	Elastase as an indicator of periodontal disease progr ession. (1573538)	Palcanis K.G.... Jeffcoat M.K.	1992	ELANE
48	Host responses in periodontal diseases: current concepts. (1573548)	Genco R.J.	1992	IL1RAPL2
49	Autoimmunity to collagen in adult periodontal disease : immunoglobulin classes in sera and tissue. (1531510)	Anusaksathien O.... Dolby A.E.	1992	CD36
50	Rheumatoid factor (RF) distribution in periodontal disease. (1890163)	ThAc J.... Ebersole J.L.	1991	CD40LG, CD79A

Genes related to periodontal disease according to GeneCards:

(show top 50)    (show all 200)

id	Symbol	Description	Score	GeneCards Section Context
1	MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	11.0	Publications
2	STATH	statherin	11.0
3	HTN3	histatin 3	11.0	Publications
4	DEFB103B	defensin, beta 103B	11.0	Publications
5	DEFB1	defensin, beta 1	11.0	Publications
6	CTSC	cathepsin C	11.0	Publications
7	DEFB4A	defensin, beta 4A	11.0	Publications
8	LAMC2	laminin, gamma 2	11.0	Publications
9	CTSG	cathepsin G	11.0	Publications
10	KLK11	kallikrein-related peptidase 11	11.0
11	CCL20	chemokine (C-C motif) ligand 20	11.0	Publications
12	IL11	interleukin 11	11.0	Publications
13	IL1A	interleukin 1, alpha	11.0	Publications
14	IL1B	interleukin 1, beta	11.0	Publications
15	SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	11.0	Publications
16	CAMP	cathelicidin antimicrobial peptide	11.0	Publications
17	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	11.0	Publications
18	OSM	oncostatin M	11.0	Publications
19	TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	11.0	Publications
20	IBSP	integrin-binding sialoprotein	11.0
21	SLPI	secretory leukocyte peptidase inhibitor	11.0	Publications
22	ELANE	elastase, neutrophil expressed	11.0	Publications
23	NLRP3	NLR family, pyrin domain containing 3	11.0	Publications
24	SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	11.0
25	PTGER2	prostaglandin E receptor 2 (subtype EP2), 53kDa	11.0
26	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
27	DSPP	dentin sialophosphoprotein	11.0	Publications
28	GUSB	glucuronidase, beta	11.0	Publications
29	S100A9	S100 calcium binding protein A9	11.0
30	IGSF3	immunoglobulin superfamily, member 3	11.0
31	HSPD1	heat shock 60kDa protein 1 (chaperonin)	11.0	Publications
32	IL17A	interleukin 17A	11.0	Publications
33	MMP13	matrix metallopeptidase 13 (collagenase 3)	11.0	Publications
34	MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	11.0	Publications
35	TNFRSF11A	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	11.0
36	AGER	advanced glycosylation end product-specific receptor	11.0	Publications
37	ALPP	alkaline phosphatase, placental	11.0	Publications
38	CCL3	chemokine (C-C motif) ligand 3	11.0	Publications
39	PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
40	FN1	fibronectin 1	11.0	Publications
41	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
42	DCN	decorin	11.0
43	IL16	interleukin 16	11.0	Publications
44	LTF	lactotransferrin	11.0	Publications
45	S100A8	S100 calcium binding protein A8	11.0	Publications
46	BSG	basigin (Ok blood group)	11.0	Publications
47	CXCL10	chemokine (C-X-C motif) ligand 10	11.0	Publications
48	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
49	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
50	MMP14	matrix metallopeptidase 14 (membrane-inserted)	11.0

Pathways related to periodontal disease according to GeneDecks:

(show top 50)    (show all 127)

id	Pathway	Score	Top Affiliating Genes
1	Activation of Matrix Metalloproteinases38	11.2	MMP1, MMP13, MMP14, MMP2, MMP3, MMP7
2	Inhibition of Matrix Metalloproteinases36	11.0	MMP1, MMP13, MMP14, MMP2, MMP25, MMP26
3	Cell adhesion ECM remodeling10	10.9	LAMC2, CD44, ITGB1, MMP1, MMP13, MMP14
4	Cell adhesion_ECM remodeling41	10.9	LAMC2, CD44, ITGB1, MMP1, MMP13, MMP14
5	Bacterial infections in CF airways41	10.8	LBP, IL1R1, CTSB, CTSL1, TLR2, DEFB4A
6	Pertussis20	10.7	CD14, ITGB1, IL10, IL12A, IL12B, IL1A
7	Immune response_TLR signaling pathways41	10.7	LBP, CD14, FN1, IRAK3, IL11, IL4
8	Toll-like receptor signaling pathway20	10.7	LBP, CD86, CD14, IL12A, IL12B, IL1B
9	Amoebiasis20	10.3	SERPINB2, LAMC2, CD14, FN1, IL12A, IL12B
10	RAR-Gamma-RXR-Alpha Degradation36	10.3	IL11, IL12A, IL16, CCL22, CCL20, CCL17
11	Chemokine signaling pathway20	10.2	FGR, IL8, MAPK1, CCR6, CCL22, CCL2
12	NFAT Signaling and Lymphocyte Interactions36	10.2	BMP6, CD4, IL11, IL12A, IL12B, IL16
13	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	10.1	VDR, BGLAP, IL1A, IL1B, IL6, IFNG
14	Chemokine Signaling36	10.1	IL8, MAPK1, CCR6, CCL22, CCL2, CCR5
15	Cytokine Network36	10.1	IL10, IL12A, IL12B, IL16, IL18, IL1A
16	Regulation of eIF4 and p70S6K36	10.1	CD4, ITGB1, FGF10, IL11, IL12A, IL12B
17	Endothelin-1 Signaling Pathway36	10.0	BMP6, IL10, IL11, IL12A, IL12B, IL16
18	PGC1Alpha Pathway36	10.0	BMP6, CD4, IL11, IL12A, IL12B, IL16
19	Transendothelial Migration of Leukocytes36	10.0	LAMC2, ITGB1, MMP1, MMP13, MMP2, MMP26
20	Immune System38	9.9	LBP, CD79A, FCGR3A, IL18, IL1R1, IL1R2
21	IL-6 Pathway36	9.7	BMP6, IL10, IL11, IL12A, IL12B, IL16
22	PEDF Induced Signaling36	9.7	BMP6, IL10, IL11, IL12A, IL12B, IL16
23	Hematopoietic cell lineage20	9.7	CD36, CD14, CD4, CD1C, CD44, IL11
24	Akt Signaling36	9.6	CD4, FGF10, IL10, IL11, IL12B, IL16
25	Influenza A20	9.6	IL12A, IL12B, IL18, IL1A, IL1B, IL6
26	African trypanosomiasis20	9.5	SELE, IL10, IL12A, IL12B, IL18, IL1B
27	MIF Mediated Glucocorticoid Regulation36	9.4	BMP6, CD14, IL10, IL11, IL12A, IL12B
28	MIF Regulation of Innate Immune Cells36	9.4	BMP6, CD14, IL10, IL11, IL12A, IL12B
29	Th1 Differentiation37	9.4	CD86, CD4, IL10, IL12A, IL12B, IL12RB2
30	all-trans-Retinoic Acid Signaling in Brain36	9.4	BMP6, IL10, IL11, IL12A, IL12B, IL16
31	SOCS Pathway36	9.3	BMP6, CD4, INS, FGF10, IL10, IL11
32	THC Differentiation Pathway36	9.3	CD86, IL10, IL12A, IL12B, IL12RB2, IL18
33	Chagas disease (American trypanosomiasis)20	9.0	IL10, IL12A, IL12B, IL1B, IL6, IL8
34	Tuberculosis20	9.0	VDR, LBP, CD14, FCGR2A, FCGR3A, FCGR3B
35	STAT3 Pathway36	8.9	BMP6, CD4, IL10, IL11, IL12A, IL12B
36	Leishmaniasis20	8.8	ITGB1, FCGR2A, FCGR3A, FCGR3B, IL10, IL12A
37	Rheumatoid arthritis20	8.7	VEGFA, CD86, MMP1, MMP3, IL11, IL17A
38	Glucocorticoid Receptor Signaling36	8.7	BMP6, CD4, IL10, IL11, IL12A, IL12B
39	Rho Family GTPases36	8.7	BMP6, LAMC2, ITGB1, FN1, FGF10, IL10
40	Molecular Mechanisms of Cancer36	8.6	BMP6, CD4, ITGB1, FN1, FGF10, IL11
41	PAK Pathway36	8.6	BMP6, FGF10, IL10, IL11, IL12A, IL12B
42	ERK Signaling36	8.5	BMP6, LAMC2, ITGB1, FN1, FGF10, IL10
43	TGF-Beta Pathway36	8.2	BMP6, CD4, FGF10, IL10, IL11, IL12A
44	MAPK Family Pathway36	8.0	BMP6, CD4, FGF10, IL10, IL11, IL12A
45	Tec Kinases Signaling36	8.0	BMP6, CD4, ITGB1, FGF10, IL10, IL11
46	Malaria20	7.8	SELE, CD36, CD40LG, IL10, IL12A, IL18
47	JAK-STAT Pathway36	7.8	BMP6, CD4, FGF10, IL10, IL11, IL12A
48	Antioxidant Action of Vitamin-C36	7.6	BMP6, CD4, FGF10, IL10, IL11, IL12A
49	p38 Signaling36	7.4	BMP6, CD4, IRAK3, FGF10, IL10, IL11
50	Cytokine-cytokine receptor interaction20	6.9	VEGFA, CD40LG, IL10, IL11, IL12A, IL12B

Compounds related to periodontal disease according to GeneDecks:

(show top 50)    (show all 500)

id	Compound	Score	Top Affiliating Genes
1	glyceraldehyde 3-phosphate32	11.2	LDHA, S100A9, MMP1, MMP13, MMP14, MMP3
2	hcec32	11.0	IL6, MAPK1, HBEGF, TLR2, DEFB4A
3	aprotinin32 9 9	13.0	SERPINF2, SERPINB2, MMP13, MMP2, MMP9, FN1
4	p00232	10.8	CD14, CD44, MMP13, MMP14, MMP3, MMP7
5	chondroitin sulfate32 18	11.7	BMP6, CD36, CD44, MMP13, MMP3, MMRN1
6	marimastat32 42 9 9	13.7	VEGFA, MMP1, MMP13, MMP14, MMP2, MMP25
7	pyridinoline32	10.6	BGLAP, PAX5, CD36, MMP3, IBSP, ALPP
8	mannose32	10.6	CD79A, CD86, CD14, CD4, MMP14, FCGR2A
9	leupeptin32	10.5	CD4, F2RL1, HSPA5, CTSB, CTSL1, LTF
10	fluvastatin32 34 9 9	13.5	COG2, CHKB, MMP1, MMP9, IL1A, IL6
11	zoledronic acid32	10.5	BGLAP, PAX5, CD36, MMP9, IBSP, ALPP
12	lipoteichoic acid32	10.5	SELE, BPI, LBP, CD14, IL10, IL12B
13	methylcellulose32	10.3	CD14, IL11, IL1A, IL4, IL6, CCR5
14	etanercept32 9 9	12.2	MMP1, MMP3, FCGR2A, FCGR3A, FCGR3B, IL10
15	1,25 dihydroxy vitamin d332	10.2	VDR, BMP6, BGLAP, S100A9, CD14, CD4
16	larc32	10.1	IL1A, CCR6, CCL22, CCL2, CCR5, CCL20
17	arachidonic acid32 9 18 9	13.1	LBP, SAA4, S100A8, S100A9, CD4, ITGB1
18	dmso32	10.1	BMP6, S100A9, CD36, MMP3, MMP7, HTN3
19	n acetylcysteine32	10.0	SELE, CD79A, MMP1, MMP2, MMP3, MMP9
20	hydroxyproline32 18	10.9	BMP6, BGLAP, PAX5, CD36, ITGB1, MMP1
21	h2o232	9.9	SERPINB2, BGLAP, S100A9, MPO, CD79A, CDKN3
22	egcg32	9.8	IL1A, CCL5, HSPG2, CAT, PTK2B, PTGS1
23	rituximab32 34 9 9	12.8	PAX5, CD79A, CD40LG, FCGR2A, FCGR3A, FCGR3B
24	chloroquine32 34 9 9	12.8	BMP6, CD79A, CD4, GSR, IL10, IL18
25	atp32	9.7	CHKB, LDHA, S100A9, CD14, CDKN3, ITGB1
26	infliximab32 9 9	11.6	SELE, VEGFA, BGLAP, MMP1, MMP3, IL10
27	groalpha32	9.6	SELE, MMP13, IL10, IL17A, IL18, IL1A
28	homocysteine32 18	10.6	COG2, SELE, NAT2, LBP, SAA4, CD14
29	epinephrine32 9 18 9	12.6	SELE, SERPINF2, BMP6, CHKB, CD79A, MMP1
30	amphotericin b32	9.2	IL1R1, IL1RAPL2, IL1RN, IL4, CCL5, IFNG
31	cysteine32	9.1	NAT2, VDR, BPI, BGLAP, CHKB, S100A8
32	folate32	9.1	SELE, NAT2, VDR, CD79A, CD40LG, MMP2
33	triptolide32	9.0	VEGFA, CD86, CD14, MMP3, IL1B, IL6
34	iron32 18	10.0	COG2, MPO, ITGB1, MMP3, FN1, IL11
35	etoposide32 42 9 9	11.9	SELE, CDKN3, CD44, MMP2, CCL3, HSP90AA1
36	tarc32	8.9	CD4, IL10, IL18, IL1A, IL4, IL4R
37	vitamin a32 9 18 9	11.8	NAT2, VDR, GSR, GPT, ALB, CAT
38	testosterone32 9 18 9	11.7	COG2, SELE, SERPINF2, VDR, BGLAP, PAX5
39	ccl332	8.6	MMP9, IL10, IL11, IL18, IL1A, IL1B
40	cholesterol32 9 18 9	11.6	COG2, SELE, SERPINF2, BSG, NAT2, BPI
41	formaldehyde32 18	9.4	SELE, MPO, CD79A, CD4, CD40LG, CDKN3
42	8-isoprostane32	8.4	SELE, SAA4, MPO, MMP2, MMP9, INS
43	creatinine32	8.4	SELE, VDR, BPI, BMP6, LBP, SAA4
44	betacarotene32	8.4	NAT2, CD79A, MMP1, GSR, IL10, IL2RA
45	herbimycin a32 42	9.0	SELE, BMP6, CD36, CD14, CD4, CD40LG
46	thymidine32 18	9.0	VDR, BMP6, CHKB, CD44, ITGB1, MMP13
47	thyroxine32 18	8.9	COG2, SERPINF2, VDR, BGLAP, CHKB, CD79A
48	polysaccharide32	7.4	SELE, SERPINF2, BPI, BMP6, CHKB, LBP
49	pdtc32	7.3	SELE, MMP1, MMP2, MMP9, IL18, IL1A
50	alanine32	6.8	COG2, SELE, SERPINF2, VDR, BPI, BMP6

Cellular components related to periodontal disease according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	lysosome	GO:005764	10.1	RRAGA, CPQ, AGA, CTSL1, CTSC, CTSB
2	membrane raft	GO:045121	10.1	ADAM17, DPP4, TLR4, TNF, ITGB1, CD4
3	proteinaceous extracellular matrix	GO:005578	10.0	FN1, AMELX, AMELY, TNFRSF11B, SPARC, ELN
4	secretory granule	GO:030141	9.8	LTF, ACPP, ELANE, TF, PLAT, CTSG
5	external side of plasma membrane	GO:009897	9.2	CXCR3, ITGB1, CD44, CD40LG, CD4, CD86
6	integral to plasma membrane	GO:005887	9.2	TLR2, AGER, HBEGF, NOTCH2, CTLA4, PTGER2
7	Golgi lumen	GO:005796	9.0	PROS1, DCN, DEFB4A, DEFB1, DEFA3, TGFB1
8	cell surface	GO:009986	8.9	ADAM17, PROM1, DPP4, TGFB1, THBD, TIMP2
9	platelet alpha granule lumen	GO:031093	8.5	HGF, PROS1, TGFB1, TIMP1, EGF, SPARC
10	extracellular region	GO:005576	7.2	NOTCH2, IBSP, IFNG, CCL5, CCL3, CCL17
11	plasma membrane	GO:005886	6.9	PTGER2, PTGS1, CTLA4, CTSG, NOD2, NOS3
12	extracellular space	GO:005615	5.1	SOD1, CRP, CTSG, CTSB, CTSH, SPARC

Biological processes related to periodontal disease according to GeneDecks:

(show top 50)    (show all 77)

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix organization	GO:030198	11.4	MMP1, MMP14, MMP2, TIMP2, TIMP1, ELN
2	extracellular matrix disassembly	GO:022617	11.4	MMP9, MMP8, MMP1, MMP13, MMP14, MMP2
3	collagen catabolic process	GO:030574	11.1	MMP3, MMP1, MMP13, MMP2, MMP26, MMP7
4	positive regulation of interleukin-6 production	GO:032755	11.1	CD36, HSPD1, TNF, IL6, NOD2, TLR2
5	defense response to Gram-positive bacterium	GO:050830	11.0	TLR2, CAMP, IL6, IL12A, FGR, MMP7
6	positive regulation of chemokine production	GO:032722	10.9	IL6, IL18, LBP, TLR4, TLR2, TNF
7	positive regulation of interferon-gamma production	GO:032729	10.8	CD40LG, IL12A, IL12B, IL12RB2, IL18, IL1B
8	biomineral tissue development	GO:031214	10.8	AMELX, IBSP, SPP1, HTN3, DSPP, STATH
9	proteolysis	GO:006508	10.7	PROS1, ELANE, DPP4, MMP7, HGF, MMP3
10	innate immune response	GO:045087	10.7	NLRP3, IL1R1, FGR, CD4, CD14, LBP
11	defense response to Gram-negative bacterium	GO:050829	10.7	LBP, CD4, MMP7, IL12B, CAMP, TLR4
12	chemotaxis	GO:006935	10.7	CXCL6, CXCL16, CXCL12, CXCL10, CX3CR1, DEFB4A
13	monocyte chemotaxis	GO:002548	10.6	CCL2, IL6, CALCA, CCL5, TNFRSF11A, TNFSF11
14	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.6	F2RL1, CCL3, IL1B, IL1A, FGF10, CD44
15	response to lipopolysaccharide	GO:032496	10.6	ADAM17, CXCL10, DCN, THBD, FGF10, IL12A
16	positive regulation of tumor necrosis factor production	GO:032760	10.5	TLR2, CD36, CD14, IL12B, IL18, CCL3
17	defense response to bacterium	GO:042742	10.5	CXCL13, CCL20, DEFB1, LYZ, LTF, DEFB4A
18	negative regulation of growth of symbiont in host	GO:044130	10.5	TLR2, ELANE, CTSG, TNF, IFNG, CD36
19	acute-phase response	GO:006953	10.3	SERPINF2, CRP, IL6, IL1RN, INS, FN1
20	response to glucocorticoid stimulus	GO:051384	10.2	BGLAP, IL10, IL1B, IL1RN, PTGS2, TNF
21	chemokine-mediated signaling pathway	GO:070098	10.2	CCL5, PTK2B, CX3CR1, CCR5, CCL2, CCR6
22	cell-cell signaling	GO:007267	10.2	CXCL10, TNFRSF11A, CXCL6, CXCL13, TNFSF10, IL11
23	cellular response to interleukin-1	GO:071347	10.1	IL17A, MMP9, IL8, PYCARD, ICAM1, CCL5
24	positive regulation of interleukin-12 production	GO:032735	10.1	CD36, IL12B, IFNG, HSPD1, TLR4, TLR2
25	humoral immune response	GO:006959	10.0	PAX5, IL6, CCR6, IFNG, TNF, NOTCH2
26	lipopolysaccharide-mediated signaling pathway	GO:031663	9.9	CCL5, TLR2, TNF, TLR4, TGFB1, LBP
27	positive regulation of smooth muscle cell proliferation	GO:048661	9.9	NOTCH3, TNF, PTGS2, ELANE, HBEGF, IL6
28	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.8	OSM, PTK2B, TLR4, IL11, HGF, CD4
29	signal transduction	GO:007165	9.8	TLR2, HBEGF, PECAM1, CXCL12, CXCL13, CXCL6
30	positive regulation of cytokine secretion	GO:050715	9.8	CD14, INS, FGR, IL10, IL1A, TLR2
31	cellular response to organic cyclic compound	GO:071407	9.8	IL18, CCL2, CCL3, CCL5, ALPL, TNF
32	cell surface receptor signaling pathway	GO:007166	9.7	CCR5, IL1R1, CXCL10, AGER, PTK2B, IFNGR2
33	response to heat	GO:009408	9.7	NOS3, CALCA, CCL2, IL1B, CD14, OSM
34	response to vitamin D	GO:033280	9.6	SPP1, TGFB1, CXCL10, PTGS2, ALPL, IL1B
35	response to ethanol	GO:045471	9.6	CCL2, SOD1, MMP9, TLR4, NOS3, CTSB
36	cellular response to lipopolysaccharide	GO:071222	9.5	CCR5, PYCARD, IFNG, TLR4, CX3CR1, CCL2
37	immune response	GO:006955	9.5	TLR2, CTSG, CTSC, CTLA4, TNFSF13B, TNFSF11
38	positive regulation of nitric oxide biosynthetic process	GO:045429	9.5	HBB, TLR2, TLR4, PTGS2, TNF, HSP90AA1
39	MAPK cascade	GO:000165	9.4	CCL2, MAPK1, IL18, IL1B, CCR5, CCL3
40	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.4	IL1B, IL6, IRAK3, TGFB1, INS, ICAM1
41	positive regulation of cell migration	GO:030335	9.3	F2RL1, CTSH, PTK2B, CCL3, FGR, INS
42	response to hypoxia	GO:001666	9.3	ADAM17, CXCL12, DPP4, PLAT, NOS3, TGFB1
43	inflammatory response	GO:006954	9.3	NLRP3, CCL22, IL8, IL6, IL1B, IL1A
44	negative regulation of apoptotic process	GO:043066	9.2	TIMP1, HSPA5, HSPD1, CAT, TNF, PTK2B
45	anti-apoptosis	GO:006916	9.1	HGF, ADAM17, SERPINB2, MPO, CD40LG, IL10
46	positive regulation of cell proliferation	GO:008284	8.3	ADAM17, CTSH, PTK2B, CXCL10, CSF3, TNFSF13B
47	platelet degranulation	GO:002576	7.9	SOD1, PECAM1, HGF, PROS1, TF, TGFB1
48	platelet activation	GO:030168	7.9	HGF, HSPA5, SPARC, EGF, TIMP1, TGFB1
49	blood coagulation	GO:007596	7.8	MMRN1, SERPINF2, SERPINB2, BSG, PECAM1, SPARC
50	response to drug	GO:042493	7.4	IFNG, ICAM1, TNF, TNFRSF11B, PTGS2, CCL5

Molecular functions related to periodontal disease according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	metalloendopeptidase activity	GO:004222	10.9	ADAM17, MMP9, MMP8, MMP7, MMP3, MMP26
2	Gram-positive bacterial cell surface binding	GO:051637	10.5	LBP, CD36, CRP, TLR2
3	chemokine activity	GO:008009	10.5	CXCL10, CXCL12, CXCL13, CXCL16, CXCL6, CCL5
4	collagen binding	GO:005518	10.5	DCN, DPP4, DSPP, SPARC, FN1, MMP9
5	lipopolysaccharide binding	GO:001530	10.2	TLR4, HSPD1, CD14, LBP, BPI
6	heparin binding	GO:008201	10.2	LTF, ELANE, HBEGF, CXCL13, CXCL6, CTSG
7	serine-type endopeptidase activity	GO:004252	10.1	HGF, DPP4, ELANE, KLK3, KLK11, LTF
8	protease binding	GO:002020	10.0	CSTA, DPP4, ELANE, TNF, IL1R1, INS
9	receptor activity	GO:004872	10.0	TNFRSF11B, NOTCH2, AGER, TLR2, TLR4, THBD
10	transmembrane signaling receptor activity	GO:004888	9.5	TNFRSF11A, AGER, TLR2, TLR4, THBD, TNFRSF10D
11	cytokine activity	GO:005125	9.2	CSF3, IL4, IL6, IFNG, TNF, TNFRSF11B
12	growth factor activity	GO:008083	7.9	AMELX, EGF, HBEGF, TGFB1, OSM, CXCL12
13	protein binding	GO:005515	4.5	CRP, PLAT, NOD2, NOS3, NOTCH2, NOTCH3