MCID: PRD007
MIFTS: 47

Periodontal Disease malady

Gastrointestinal diseases, Oral diseases categories

Aliases & Classifications for Periodontal Disease

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 61UMLS, 33MeSH, 56SNOMED-CT, 39NCIt, 25ICD10
See all sources

Aliases & Descriptions for Periodontal Disease:

Name: Periodontal Disease 8 10
Periodontal Diseases 44 61
 
Disease of Supporting Structures of Teeth, Nos 8
Periodontium Disorder 8


Classifications:



External Ids:

Disease Ontology8 DOID:3388
MeSH33 D010510
NCIt39 C63743
ICD1025 K05.6

Summaries for Periodontal Disease

About this section
MalaCards based summary: Periodontal Disease, also known as periodontal diseases, is related to periodontitis and gingivitis. An important gene associated with Periodontal Disease is MMP8 (matrix metallopeptidase 8 (neutrophil collagenase)), and among its related pathways are Cytokine Network and Cytokines and Inflammatory Response. The drugs chlorhexidine and chlorhexidine gluconate and the compounds ciprofloxacin and hydroxamate have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and t cells, and related mouse phenotype immune system.

Related Diseases for Periodontal Disease

About this section

Diseases related to Periodontal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis32.3MMP8, IL1B, IL1A
2gingivitis31.2IL1A, IL1B, MMP8, SERPINB2
3aggressive periodontitis31.1IL1A, MMP8
4arthritis31.1IL1A, IL1B
5bacterial vaginosis30.7IL1B, IL1A
6atherosclerosis30.4SERPINB2, MMP8, IL1B, IL1A
7duodenal ulcer30.2DEFB1, DEFB4A
8rheumatoid arthritis30.2FCGR3B, SERPINB2, MMP8, CXCL6, IL1B, IL1A
9psoriatic arthritis30.1IL1B, IL1A
10psoriasis30.0DEFB4A, SERPINB2, IL1B, IL1A
11tuberculosis29.9DEFB4A, IL1B
12inflammatory bowel disease29.7DEFB4A, DEFB103B, DEFB1, IL1B
13funisitis10.5MMP8
14periapical granuloma10.5MMP8
15oral candidiasis10.4DEFB4A
16obesity10.4
17candidiasis10.4DEFB4A
18dental caries10.4
19osteoporosis10.4
20intervertebral disc disease10.4IL1B
21chronic ulcer of skin10.3DEFB4A, MMP8
22tonsillitis10.3DEFB1, DEFB4A
23endotheliitis10.3
24periodontosis10.3
25artery disease10.3
26middle ear cholesteatoma10.3DEFB4A, IL1A
27bacterial meningitis10.3MMP8, IL1B
28chorioamnionitis10.2MMP8, IL1B
29coronary artery disease10.2
30kidney disease10.2
31gingival overgrowth10.2IL1B, IL1A
32otitis media10.2DEFB1, IL1B
33acne10.2DEFB4A, DEFB1, IL1A
34synovitis10.2IL1A, IL1B, MMP8
35eclampsia10.2
36root caries10.2
37amyloidosis10.2
38pre-eclampsia10.2
39malaria10.1IL1A, IL1B
40sinusitis10.1CXCL6, DEFB4A
41thrombocytosis10.1IL1A, IL1B
42atopic dermatitis10.1DEFB4A, DEFB103B, IL1A
43cholesteatoma10.1IL1A, MMP8, DEFB1, DEFB4A
44gastritis10.1IL1B, DEFB1, DEFB4A
45chediak-higashi syndrome10.1
46myocardial infarction10.1
47scurvy10.1
48acute myocardial infarction10.1
49gingival recession10.1
50osteonecrosis10.1

Graphical network of the top 20 diseases related to Periodontal Disease:



Diseases related to periodontal disease

Symptoms for Periodontal Disease

About this section

Drugs & Therapeutics for Periodontal Disease

About this section

Drug clinical trials:

Search ClinicalTrials for Periodontal Disease

Search NIH Clinical Center for Periodontal Disease

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Periodontal Disease

About this section

Anatomical Context for Periodontal Disease

About this section

MalaCards organs/tissues related to Periodontal Disease:

31
Bone, Neutrophil, T cells, Heart, Endothelial, Kidney, Testes, Monocytes, Prostate, B cells, Cortex, Breast, Nk cells

Animal Models for Periodontal Disease or affiliated genes

About this section

MGI Mouse Phenotypes related to Periodontal Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.8IL1A, IL1B, IL17F, CXCL6, MMP8, SERPINB2

Publications for Periodontal Disease

About this section

Articles related to Periodontal Disease:

(show top 50)    (show all 866)
idTitleAuthorsYear
1
IL-33 Exacerbates Periodontal Disease through Induction of RANKL. (25808546)
2015
2
Cardiovascular Risks Associated with Incident and Prevalent Periodontal Disease. (25385537)
2014
3
Surgical treatment for patients with periodontal disease reduces risk of end-stage renal disease: a nationwide population-based retrospective cohort study. (23646848)
2014
4
Fluoxetine reduces periodontal disease progression in a conditioned fear stress model in rats. (23425324)
2013
5
Peripheral arterial disease associated with caries and periodontal disease. (22680302)
2013
6
Influence of periodontal disease on systemic disease: inversion of a paradigm: a review. (23904870)
2013
7
Periodontal disease: a covert source of inflammation in chronic kidney disease patients. (23840952)
2013
8
Periodontal disease and type 1 diabetes mellitus: associations with glycemic control and complications: an Indian perspective. (23680241)
2013
9
Impact of plasma of argon cleaning treatment on implant abutments in patients with a history of periodontal disease and thin biotype: radiographic results at 24-month follow-up of a RCT. (24191873)
2013
10
Aspirin intake: Can be a confounding factor in clinical trial for periodontal disease. (24302845)
2013
11
Orthodontic treatment for a patient with advanced periodontal disease: 11-year follow-up. (23992818)
2013
12
Change of periodontal disease status during and after pregnancy. (22873653)
2013
13
Association between periodontal disease and venous thromboembolic disease. (23757458)
2013
14
Phenotypic and genotypic features of Aggregatibacter actinomycetemcomitans isolated from patients with periodontal disease. (23391608)
2013
15
Lactoferrin, a marker for periodontal disease. (23432422)
2013
16
Periodontal disease and risk of psoriasis among nurses in the United States. (23374087)
2013
17
Diagnosis and management of vertical bony defects in periodontal disease. (22782040)
2012
18
CDC: Half of American adults have periodontal disease. (23256312)
2012
19
Direct recognition of Fusobacterium nucleatum by the NK cell natural cytotoxicity receptor NKp46 aggravates periodontal disease. (22457623)
2012
20
AHA statement on periodontal disease and heart disease. (22558948)
2012
21
Periodontal disease and decreased kidney function in Japanese elderly. (22001179)
2012
22
Letter to the editor: does periodontal disease cause amyloidosis? (22292602)
2012
23
Clinical indicators of periodontal disease in patients with coronary heart disease: a 10 years longitudinal study. (22173486)
2012
24
Association between volatile sulfur compounds and periodontal disease progression in elderly non-smokers. (21861638)
2012
25
Histamine modulates salivary secretion and diminishes the progression of periodontal disease in rat experimental periodontitis. (22261710)
2012
26
Periodontal disease decreases insulin sensitivity and insulin signaling. (22087804)
2012
27
Effect of periodontal treatment on glycosylated hemoglobin levels in elderly patients with periodontal disease and type 2 diabetes. (22040558)
2011
28
Photodynamic therapy reduces bone resorption and decreases inflammatory response in an experimental rat periodontal disease model. (21651385)
2011
29
Interaction between periodontal disease and systemic secondary amyloidosis: from inflammation to amyloidosis. (21043797)
2011
30
Relationship between saturated fatty acids and periodontal disease. (21505204)
2011
31
A clinical study of the relationship between diabetes mellitus and periodontal disease. (22368365)
2011
32
Serum placental growth factor, vascular endothelial growth factor, soluble vascular endothelial growth factor receptor-1 and -2 levels in periodontal disease, and adverse pregnancy outcomes. (21513467)
2011
33
Pediatric obesity and periodontal disease: a systematic review of the literature. (21716988)
2011
34
Study on maternal periodontal diseases of the relationships between porphyromonas gingivalis, serum pro-immflamatory mediators and preterm low birth weight]. (20077889)
2009
35
Polymorphism of genes encoding toll-like receptors and inflammatory cytokines in periodontal disease in the Japanese population. (18714935)
2008
36
Periodontal disease in patients from the original Kostmann family with severe congenital neutropenia. (16584360)
2006
37
Identification of epithelial auto-antigens associated with periodontal disease. (15654832)
2005
38
The potential role of interleukin-17 in the immunopathology of periodontal disease. (15811054)
2005
39
Analysis of FcgammaRIIIb genotype of periodontal disease in the Han nationality in China]. (16155708)
2005
40
The systemic immune response is more prominent than the mucosal immune response in the pathogenesis of periodontal disease. (12956653)
2003
41
Self-heat shock protein 60 induces tumour necrosis factor-alpha in monocyte-derived macrophage: possible role in chronic inflammatory periodontal disease. (11882035)
2002
42
GCF IL-1beta profiles in periodontal disease. (11846849)
2002
43
Chemokines in human periodontal disease tissues. (11472436)
2001
44
Aspartat aminotransferase--a marker of periodontal disease activity. (10402712)
1999
45
Cysteine protease inhibitory activity and levels of salivary cystatins in whole saliva of periodontally diseased patients. (10697800)
1999
46
Relevance of local Th2-type cytokine mRNA expression in immunocompetent infiltrates in inflamed gingival tissue to periodontal diseases. (9010272)
1997
47
Molecular and cellular mechanisms for periodontal diseases: role of Th1 and Th2 type cytokines in induction of mucosal inflammation. (9085220)
1997
48
Salivary levels of alpha 2-macroglobulin, alpha 1-antitrypsin, C-reactive protein, cathepsin G and elastase in humans with or without destructive periodontal disease. (8850655)
1995
49
Adhesion molecule expression in chronic inflammatory periodontal disease tissue. (7509385)
1994
50
Cysteine proteinases and inhibitors in inflammation: their role in periodontal disease. (8315571)
1993

Variations for Periodontal Disease

About this section

Expression for genes affiliated with Periodontal Disease

About this section
Search GEO for disease gene expression data for Periodontal Disease.

Pathways for genes affiliated with Periodontal Disease

About this section

Pathways related to Periodontal Disease according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7IL1B, IL1A
29.7IL1A, IL1B
39.7IL1A, IL1B
49.7IL1A, IL1B
5
Show member pathways
IL-1 Signaling Pathway36
IL1-mediated signaling events36
9.7IL1A, IL1B
69.5FCGR3B, IL1B, IL1A
79.5IL1A, IL1B, FCGR3B
8
Show member pathways
9.4IL17F, CXCL6
9
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
9.4IL1A, IL1B, DEFB4A
109.4IL1A, IL1B, SERPINB2
119.1CXCL6, IL1B, IL1A
129.1CXCL6, IL1B, IL1A
13
Show member pathways
9.0IL1A, IL1B, IL17F, FCGR3B
14
Show member pathways
8.6DEFB1, DEFB103B, DEFA3, DEFB4A

Compounds for genes affiliated with Periodontal Disease

About this section

Compounds related to Periodontal Disease according to GeneCards Suite gene sharing:

(show all 47)
idCompoundScoreTop Affiliating Genes
1ciprofloxacin44 50 1112.2DEFB1, IL1A
2hydroxamate4410.2MMP8, SERPINB2
3muramyl tripeptide4410.1IL1A, IL1B
4tenidap44 2811.1IL1A, IL1B
5clodronate44 50 1112.1IL1B, MMP8
6git 276010.1IL1B, IL1A
74-ipp6010.1IL1A, IL1B
8aacocf34410.1IL1B, IL1A
9gold sodium thiomalate4410.1IL1A, IL1B
10auranofin28 44 60 1113.1IL1B, IL1A
11pirfenidone44 6011.1IL1A, IL1B
12naproxen44 24 1112.1IL1A, IL1B
13helenalin4410.1DEFB4A, IL1B
14as 10144 6011.0IL1A, IL1B
15minocycline44 1111.0IL1B, IL1A
16flagellin44 2811.0DEFB4A, IL1B
17gm-csf44 2811.0IL1A, IL1B
18grobeta4410.0CXCL6, IL1A
19lipoteichoic acid449.9IL1B, DEFB4A
20polymyxin b449.9DEFB1, IL1A, IL1B
21sulfasalazine28 44 50 1112.9IL1A, IL1B
22leukotriene b444 60 2411.9IL1A, FCGR3B, IL1B
23ns 39844 6010.8IL1B, IL1A
24polyinosinic-polycytidylic acid449.8IL1B, IL1A
25mg 13244 6010.8IL1B, DEFB4A, IL1A
26fmlp449.8IL1A, FCGR3B, IL1B
27il 10449.7IL1B, IL1A
28etanercept44 50 1111.7IL1B, FCGR3B
29h2o2449.6IL1A, SERPINB2, FCGR3B, MMP8
30ribonucleic acid449.6IL1A, SERPINB2, IL1B
31superoxide44 2410.6FCGR3B, SERPINB2, IL1B, MMP8
32sb 20358044 6010.5IL1B, DEFB4A, IL1A
33pge2449.5MMP8, IL1B, IL1A, SERPINB2
34groalpha449.5IL1A, IL1B, CXCL6
35heparin44 28 24 1112.5CFHR1, SERPINB2, DEFB4A, IL1A
36endotoxin449.5SERPINB2, IL1B, IL1A, DEFB4A
37genistein44 28 60 1 24 1114.3MMP8, FCGR3B, IL1B, DEFB4A, IL1A
38anti-fungal449.2DEFB103B, DEFB4A, DEFA3
39progesterone44 28 60 24 1113.2DEFB103B, SERPINB2, DEFB4A, IL1A, MMP8
40nitric oxide44 24 1111.1SERPINB2, MMP8, IL1B, IL1A
41retinoic acid44 2410.0IL1B, MMP8, SERPINB2, DEFB1, DEFB4A, IL1A
42rantes449.0IL1A, IL1B, CXCL6, DEFB1, DEFB4A
43vegf448.9IL1A, MMP8, IL1B, SERPINB2, CXCL6
44dexamethasone44 50 28 1111.7DEFB103B, SERPINB2, IL1B, IL1A, DEFB4A, DEFB1
45hbd2448.5IL1B, DEFB1, DEFB103B, DEFA3, DEFB4A
46calcium44 50 24 1111.4MMP8, CXCL6, FCGR3B, DEFB4A, DEFB103B, SERPINB2
47serine448.4IL1A, CXCL6, MMP8, SERPINB2, FCGR3B

GO Terms for genes affiliated with Periodontal Disease

About this section

Cellular components related to Periodontal Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00057969.1DEFB1, DEFA3, DEFB4A
2extracellular spaceGO:00056156.6DEFA3, CFHR1, SERPINB2, MMP8, CXCL6, IL17F
3extracellular regionGO:00055766.3IL1A, DEFB4A, DEFA3, DEFB1, FCGR3B, SERPINB2

Biological processes related to Periodontal Disease according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1fever generationGO:00016609.9IL1B, IL1A
2ectopic germ cell programmed cell deathGO:00352349.9IL1A, IL1B
3positive regulation of interleukin-2 biosynthetic processGO:00450869.8IL1A, IL1B
4positive regulation vascular endothelial growth factor productionGO:00105759.8IL1A, IL1B
5positive regulation of mitosisGO:00458409.7IL1B, IL1A
6positive regulation of cell divisionGO:00517819.7IL1A, IL1B
7negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012409.6IL1A, IL1B
8chemotaxisGO:00069359.4DEFB4A, DEFB1, CXCL6
9extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.4IL1A, IL1B
10inflammatory responseGO:00069548.9IL1A, IL1B, IL17F, CXCL6
11immune responseGO:00069558.5IL1A, IL1B, CXCL6, FCGR3B, DEFB1, DEFB4A

Molecular functions related to Periodontal Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00051499.4IL1A, IL1B
2cytokine activityGO:00051259.3IL1A, IL1B, IL17F

Sources for Periodontal Disease

About this section
2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet