MCID: PRD007
MIFTS: 53

Periodontal Disease malady

Gastrointestinal category

Summaries for Periodontal Disease

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 A periodontal disease in its widest meaning is any disease that affects one or more of the periodontal... more...

MalaCards: Periodontal Disease, also known as periodontal diseases, is related to arthritis and osteoporosis. An important gene associated with Periodontal Disease is MMP8 (matrix metallopeptidase 8 (neutrophil collagenase)), and among its related pathways are Immune System and PEDF Induced Signaling. The drugs chlorhexidine and chlorhexidine gluconate and the compounds calcium and retinoic acid have been mentioned in the context of this disorder. Related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Periodontal Disease

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

periodontal disease 8 10
periodontal diseases 45 61
disease of supporting structures of teeth, nos 8
periodontium disorder 8


External Ids:

Disease Ontology8 DOID:3388
MeSH35 D010510
NCIt40 C63743
ICD1025 K05.6

Related Diseases for Periodontal Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Periodontal Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 228)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.8TNFSF11, IL17A, IL1A, CTSG, IL1B
2osteoporosis30.6TNFSF11, MMP13, IL11, TNFRSF11B, MMP8
3vascular disease30.6IL1B, IL1A, ELANE
4atherosclerosis30.5SERPINB2, TNFRSF11B, IL1A, IL1B, IL17A, MMP13
5pulmonary disease, chronic obstructive30.4MMP8, DEFB1, IL17A, ELANE, CCL20, CTSG
6bacterial vaginosis30.3IL1A, IL1B
7coronary artery disease,30.3TNFSF11, MMP13, IL17A, TNFRSF11B
8coronary heart disease30.3MMP8
9aggressive periodontitis30.3IL1A, MMP8
10squamous cell carcinoma30.1DEFB4A, DEFB1, CTSG, CAMP, KLK11, MMP13
11osteoporosis, postmenopausal30.1TNFRSF11B, IL11, TNFSF11
12acute myocardial infarction30.1TNFSF11, MMP8
13root resorption30.1TNFRSF11B
14tuberculosis29.9DEFB4A, GUSB, IL17A, IL1B, IL11, CAMP
15psoriatic arthritis29.9IL1A, TNFSF11, IL1B, TNFRSF11B
16rheumatic disease29.9TNFRSF11B, TNFSF11, IL11
17systemic lupus erythematosus29.9CD79A, GUSB, CTSG, IL17A
18tooth disease10.5
19dent's disease10.5
20bone resorption disease10.3
21lip disease10.3
22periodontosis10.2
23bone inflammation disease10.2
24eclampsia10.2
25root caries10.2
26amyloidosis10.2
27nutrition disease10.2
28peripheral vascular disease10.1
29hemoglobin d disease10.1
30hemoglobin e disease10.1
31chediak-higashi syndrome10.1
32gingival recession10.1
33gestational diabetes10.1
34hypophosphatasia10.1
35n syndrome10.1
36scurvy10.1
37bone remodeling disease10.1
38cardiovascular disease risk factor10.1
39sleep apnea10.1
40osteoarthritis10.0MMP8, SERPINB2, MMP13, IL17A, IL1B, CCL20
41rheumatoid arthritis10.0ELANE, MMP13, MMP8, SERPINB2, IL1B, IL1A
42gingivitis10.0TNFSF11, TNFRSF11B, CTSG, GUSB, IL1A, IL1B
43asthma10.0IL17A, IL1B, IL11, CD79A, DEFB4A, DEFB1
44psoriasis10.0KLK11, CCL20, CAMP, GUSB, DEFB4A, IL11
45cystic fibrosis10.0ELANE, IL17A, DEFB4A, DEFB103B, DEFB1, GUSB
46periodontitis10.0TNFSF11, IL17A, IL1B, IL1A, TNFRSF11B, DEFB1
47sepsis10.0DEFB1, CAMP, ELANE, CTSG, DEFB4A, SERPINB2
48pneumonia10.0DEFB4A, IL17A, DEFB1, MMP8, IL1B, CD79A
49leukemia10.0CCL20, CTSG, IL17A, SERPINB2, IL1A, IL11
50breast cancer10.0TNFSF11, SERPINB2, MMP8, KLK11, IL17A, CAMP

Graphical network of the top 20 diseases related to Periodontal Disease:



Diseases related to periodontal disease

Clinical Features for Periodontal Disease

Drugs & Therapeutics for Periodontal Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Periodontal Disease

Drug clinical trials:

Search ClinicalTrials for Periodontal Disease

Search NIH Clinical Center for Periodontal Disease

Search CenterWatch for Periodontal Disease

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Periodontal Disease

Anatomical Context for Periodontal Disease

Animal Models for Periodontal Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Periodontal Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539711.0TNFRSF11B, CTSG, GUSB, CD79A, IL1A, IL17A
2MP:000538710.9ELANE, CAMP, TNFSF11, TNFRSF11B, CTSG, DEFB1

Publications for Periodontal Disease

Sources:
51PubMed
See all sources

Articles related to Periodontal Disease:

(show top 50)    (show all 883)
idTitleAuthorsYear
1
The relationship between metabolic conditions and prevalence of periodontal disease in rural Korean elderly. (24075494)
2014
2
Periodontal disease associated with blood glucose levels in urban Koreans aged 50A years and older: the Dong-gu study. (24428748)
2014
3
Effect of Non-surgical Periodontal Therapy on Serum Levels of TNF-a, IL-6 and C-reactive Protein in Periodontitis Subjects with Stable Coronary Heart Disease. (24436950)
2013
4
Dietary antioxidants and periodontal disease in community-based older Japanese: a 2-year follow-up study. (22613693)
2013
5
An integrated risk assessment tool for team-based periodontal disease management. (23920924)
2013
6
Is the Schneiderian membrane thickness affected by periodontal disease? A cone beam computed tomography-based extended case series. (24079099)
2013
7
Relationship between normal serum creatinine concentration and periodontal disease in Japanese middle-aged males. (22390548)
2013
8
A retrospective cohort study on the association between periapical abscess, advanced periodontal disease, and the national oral health screening program among Korean adults. (22186394)
2013
9
Periodontal disease in chronic kidney disease and end-stage renal disease patients: a review. (23802000)
2013
10
Effect of periodontal disease on diabetes: systematic review of epidemiologic observational evidence. (23627324)
2013
11
Maternal periodontal disease in rats decreases insulin sensitivity and insulin signaling in adult offspring. (22702519)
2013
12
In vivo inflammation mapping of periodontal disease based on diffuse reflectance spectral imaging: a clinical study. (23400418)
2013
13
Diagnosis and management of vertical bony defects in periodontal disease. (22782040)
2012
14
Clinical indicators of periodontal disease in patients with coronary heart disease: a 10 years longitudinal study. (22173486)
2012
15
MIF induces osteoclast differentiation and contributes to progression of periodontal disease in mice. (22016007)
2012
16
The AHA scientific statement on periodontal disease and ASVD: how should clinicians respond? (22774327)
2012
17
Relationship between maternal periodontal disease and Apgar score of newborns. (23346464)
2012
18
Influence of maternal periodontal disease as a risk factor for low birth weight infants in Indian population. (23250174)
2012
19
Translating science into action--prevention of periodontal disease at patient level. (22909114)
2012
20
Lipid profile of people with diabetes mellitus type 2 and periodontal disease. (22154377)
2012
21
Periodontal disease and systemic complications. (23318743)
2012
22
Periodontal disease and preterm birth. (22370104)
2012
23
Historical perspectives on theories of periodontal disease etiology. (22133374)
2012
24
Lymphangiogenesis is induced during development of periodontal disease. (21979132)
2012
25
Porphyromonas gingivalis-mediated shedding of extracellular matrix metalloproteinase inducer (EMMPRIN) by oral epithelial cells: a potential role in inflammatory periodontal disease. (21835259)
2011
26
Periodontal disease and nitric oxide levels in low risk women with preterm labor. (21621901)
2011
27
Periodontal disease as a risk for dental implant failure over time: a long-term historical cohort study. (21635280)
2011
28
Experimental arthritis triggers periodontal disease in mice: involvement of TNF-I+ and the oral Microbiota. (21890656)
2011
29
Porphyromonas gingivalis sinks teeth into the oral microbiota and periodontal disease. (22100158)
2011
30
Serum levels of oncostatin M (a gp 130 cytokine): an inflammatory biomarker in periodontal disease. (20408777)
2010
31
Anticytokine therapy for periodontal diseases: Where are we now? (20407652)
2009
32
Tumor necrosis factor-alpha -308G/A single nucleotide polymorphism and red-complex periodontopathogens are independently associated with increased levels of tumor necrosis factor-alpha in diseased periodontal tissues. (19076989)
2009
33
The interplay of lipopolysaccharide-binding protein and cytokines in periodontal health and disease. (19558463)
2009
34
Activation of cyclic AMP response element-binding protein (CREB) in aggressive periodontal disease. (19898718)
2009
35
Relationship between periodontal findings and specific polymorphisms of interleukin-1alpha and -1beta in Turkish patients with BehAset's disease. (17960403)
2008
36
Kindler syndrome and periodontal disease: review of the literature and a 12-year follow-up case. (18454678)
2008
37
Gingival crevicular fluid PGE2, IL-1beta, t-PA, PAI-2 levels in type 2 diabetes and relationship with periodontal disease. (18472001)
2008
38
Interleukin-6 -174 genotype, periodontal disease and adverse pregnancy outcomes: a pilot study. (18181010)
2008
39
Lack of association between the TNF-alpha -308 (G/A) genetic polymorphism and periodontal disease in Brazilians. (19148387)
2008
40
Progression of periodontal disease and interleukin-10 gene polymorphism. (18447856)
2008
41
Gingival crevicular fluid osteopontin levels in periodontal health and disease. (17032109)
2006
42
Regulatory T-cells infiltrate periodontal disease tissues. (15972593)
2005
43
Gingival crevicular fluid EMAP-II, MIP-1alpha and MIP-1beta levels of patients with periodontal disease. (15998272)
2005
44
Periodontal disease and diabetes mellitus: the role of tumor necrosis factor-alpha in a 2-way relationship. (12593603)
2003
45
Specific fibronectin fragments as markers of periodontal disease status. (12416766)
2002
46
The potential role of chemokines and inflammatory cytokines in periodontal disease progression. (10194065)
1999
47
Oral scurvy and periodontal disease. (9433025)
1997
48
Effects of tetracyclines on neutrophil, gingival, and salivary collagenases. A functional and western-blot assessment with special reference to their cellular sources in periodontal diseases. (7978785)
1994
49
Five parameters of gingival crevicular fluid from eight surfaces in periodontal health and disease. (1328590)
1992
50
Interleukin-2, interleukin-2 receptor and interleukin-4 levels are elevated in the sera of patients with periodontal disease. (1832452)
1991

Genetic Variations for Periodontal Disease

Expression for genes affiliated with Periodontal Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Periodontal Disease

Search GEO for disease gene expression data for Periodontal Disease.

Pathways for genes affiliated with Periodontal Disease

Sources:
54Reactome, 52QIAGEN, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database
See all sources

Pathways related to Periodontal Disease according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8DEFB103B, DEFB4A, CD79A, IL1A, IL1B, DEFB1
2
Hide members
10.8IL1A, IL11, TNFRSF11B, TNFSF11, CCL20, IL17A
3
Hide members
10.8IL1B, TNFSF11, CCL20, IL11, IL1A
4
Hide members
10.8IL1A, IL11, TNFSF11, CCL20, IL1B
5
Hide members
10.7IL1B, IL1A, TNFRSF11B, TNFSF11
610.7TNFSF11, IL1A, IL1B, TNFRSF11B
7
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.7IL1B, IL1A, TNFRSF11B, TNFSF11
8
Immune response Bacterial infections in normal airways
Hide members
10.7CCL20, DEFB4A, IL1A, IL1B
9
Hide members
10.7CD79A, IL1A, IL1B, IL17A
10
Hide members
10.7KLK11, CTSG, MMP13, MMP8
1110.7ELANE, MMP8, CTSG
12
Hide members
10.7CTSG, MMP8, MMP13
13
Hide members
10.7DEFB1, DEFB4A, DEFB103B
1410.7IL11, IL1A, IL1B
1510.7IL11, TNFSF11, CCL20
1610.6IL1B, IL1A
1710.6TNFRSF11B, TNFSF11

Compounds for genes affiliated with Periodontal Disease

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Periodontal Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1calcium45 50 11 2414.7CAMP, DEFB4A, KLK11, CCL20, TNFSF11, SERPINB2
2retinoic acid45 2412.7ELANE, TNFRSF11B, CTSG, DEFB1, DEFB4A, CD79A
3heparin45 29 11 2414.6ELANE, CTSG, SERPINB2, MMP13, IL1A, IL11
4nitric oxide45 11 2413.6SERPINB2, CCL20, IL11, IL1A, IL1B, IL17A
5vegf4511.6MMP13, CD79A, IL1A, IL1B, SERPINB2, IL17A
6cysteine4511.6CD79A, DEFB4A, DEFB103B, CTSG, TNFRSF11B, HTN3
7dexamethasone45 50 29 1114.5CD79A, SERPINB2, CCL20, CAMP, TNFSF11, DEFB1
8steroid4511.5CAMP, CD79A, KLK11, IL11, IL17A, TNFRSF11B
9genistein45 29 60 2 11 2416.4IL1B, MMP8, MMP13, IL1A, GUSB, TNFSF11
10cyclosporin a45 29 6013.4MMP8, SERPINB2, ELANE, IL17A, IL11, TNFRSF11B
11prostaglandin4511.4MMP13, IL17A, IL1B, IL1A, IL11, TNFRSF11B
12fibrinogen4511.3TNFRSF11B, CTSG, IL11, ELANE, SERPINB2, MMP8
13rantes4511.3IL1B, CCL20, DEFB4A, IL17A, IL1A, IL11
14endotoxin4511.3CAMP, CCL20, CTSG, DEFB4A, IL11, SERPINB2
15polymyxin b4511.3CAMP, TNFSF11, TNFRSF11B, DEFB1, IL1A, IL1B
16sb 20358045 6012.3MMP13, TNFRSF11B, IL1B, IL17A, IL1A, DEFB4A
17vitamin d4511.2ELANE, IL1A, IL11, CD79A, TNFRSF11B, TNFSF11
18progesterone45 60 29 11 2415.2SERPINB2, MMP8, DEFB4A, IL1A, IL11, CAMP
19histamine45 29 2413.2IL11, CTSG, DEFB4A, CD79A, IL1B, CAMP
20aprotinin45 1112.2IL1A, KLK11, CTSG, ELANE, SERPINB2, MMP13
21leukotriene b445 60 2413.2CTSG, GUSB, IL11, ELANE, IL1B, IL1A
22serine4511.2MMP13, CAMP, MMP8, IL1A, CTSG, TNFRSF11B
23hbd24511.2CAMP, DEFB4A, DEFB1, DEFB103B, IL1B
24clodronate45 50 1113.2MMP8, TNFSF11, MMP13, IL1B, TNFRSF11B
25hyaluronic acid45 2412.2CD79A, IL1A, IL1B, MMP13, ELANE, IL11
26alendronate45 50 1113.2TNFSF11, MMP8, MMP13, IL11, TNFRSF11B
27ns 39845 6012.2TNFRSF11B, IL17A, IL1B, IL1A, TNFSF11
28etanercept45 50 1113.2TNFSF11, TNFRSF11B, IL11, IL1B, IL17A
29fmlp4511.1GUSB, CAMP, CTSG, IL1A, IL1B, ELANE
30infliximab45 50 1113.1IL11, IL1B, IL17A, TNFRSF11B, TNFSF11
31peptidoglycan45 2912.1CCL20, CTSG, TNFSF11, DEFB4A, IL1B
32arachidonic acid45 29 11 2414.1TNFRSF11B, TNFSF11, CAMP, CTSG, IL11, IL1B
33doxycycline45 1112.1MMP8, TNFSF11, ELANE, MMP13, CD79A
34calcitriol45 60 11 2414.1IL1B, IL1A, IL11, TNFRSF11B, TNFSF11, CAMP
35(4-aminophenyl)mercuric acetate4511.1CTSG, MMP13, MMP8, ELANE
36hydroxyapatite4511.1MMP13, IL11, HTN3, TNFRSF11B, TNFSF11
37aspirin45 50 29 2414.0CTSG, GUSB, IL1B, TNFRSF11B, ELANE, CD79A
38pmma4511.0CD79A, HTN3, TNFRSF11B, TNFSF11
39estrogen4511.0DEFB4A, CD79A
40indomethacin45 60 29 1114.0CTSG
41sp 60012545 6012.0MMP13, IL17A, DEFB4A, TNFSF11, IL1B
42cycloheximide4510.9CTSG, SERPINB2
43superoxide45 2411.9ELANE, SERPINB2, GUSB, MMP8, IL1B
44groalpha4510.9IL1B, IL1A, MMP13, IL17A
45sodium dodecylsulfate4510.8HTN3, CD79A, ELANE, IL1A, CTSG
46forskolin45 50 1112.8CAMP, IL11
47p0024510.8MMP8, DEFB4A, MMP13, IL17A, TNFRSF11B
481,25 dihydroxy vitamin d34510.7TNFSF11, IL11, TNFRSF11B
49thymidine45 2411.6MMP13, IL17A, IL1B, IL1A, IL11, CTSG
50gm-csf45 2911.4IL11

GO Terms for genes affiliated with Periodontal Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Periodontal Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.3ELANE, KLK11, CCL20, CAMP, TNFSF11, TNFRSF11B
2extracellular spaceGO:00561510.8CCL20, TNFSF11, TNFRSF11B, CTSG, IL11, IL1A
3secretory granuleGO:03014110.7ELANE, IL1B, CTSG

Biological processes related to Periodontal Disease according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.2IL17A, CCL20, TNFSF11, CTSG, DEFB1, DEFB4A
2defense response to bacteriumGO:04274211.0CCL20, CAMP, HTN3, DEFB1, DEFB4A
3extracellular matrix organizationGO:03019811.0TNFRSF11B, CTSG, MMP13, MMP8, ELANE
4extracellular matrix disassemblyGO:02261710.9ELANE, MMP8, MMP13, CTSG
5proteolysisGO:00650810.8ELANE, MMP8, MMP13, CTSG, KLK11
6fever generationGO:00166010.7IL1A, IL1B
7inflammatory responseGO:00695410.7IL17A, IL1B, IL1A, CCL20
8positive regulation of immune responseGO:05077810.7ELANE, CTSG
9collagen catabolic processGO:03057410.7MMP13, MMP8, ELANE
10cell-cell signalingGO:00726710.6IL17A, IL1B, IL11, CCL20
11positive regulation of interleukin-2 biosynthetic processGO:04508610.3IL1A, IL1B

Molecular functions related to Periodontal Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.7IL17A, IL1B, IL1A, IL11, TNFRSF11B, TNFSF11
2interleukin-1 receptor bindingGO:00514910.6IL1B, IL1A
3serine-type endopeptidase activityGO:00425210.4KLK11, CTSG, MMP8, ELANE

Products for genes affiliated with Periodontal Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Periodontal Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet