MCID: PRD007
MIFTS: 47

Periodontal Disease malady

Gastrointestinal diseases, Oral diseases categories

Summaries for Periodontal Disease

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MalaCards based summary: Periodontal Disease, also known as periodontal diseases, is related to periodontitis and gingivitis. An important gene associated with Periodontal Disease is MMP8 (matrix metallopeptidase 8 (neutrophil collagenase)), and among its related pathways are Cytokine Network and Cytokines and Inflammatory Response. The drugs chlorhexidine and chlorhexidine gluconate and the compounds ciprofloxacin and hydroxamate have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and t cells, and related mouse phenotype immune system.

Aliases & Classifications for Periodontal Disease

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 33MeSH, 55SNOMED-CT, 38NCIt, 25ICD10
See all sources

Periodontal Disease, Aliases & Descriptions:

Name: Periodontal Disease 9 11
Periodontal Diseases 43 60
 
Disease of Supporting Structures of Teeth, Nos 9
Periodontium Disorder 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Oral diseases


External Ids:

Disease Ontology9 DOID:3388
MeSH33 D010510
NCIt38 C63743
ICD1025 K05.6

Related Diseases for Periodontal Disease

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Diseases related to Periodontal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis32.3MMP8, IL1B, IL1A
2gingivitis31.2IL1A, IL1B, MMP8, SERPINB2
3aggressive periodontitis31.1IL1A, MMP8
4arthritis31.1IL1A, IL1B
5bacterial vaginosis30.7IL1B, IL1A
6atherosclerosis30.4SERPINB2, MMP8, IL1B, IL1A
7duodenal ulcer30.2DEFB1, DEFB4A
8rheumatoid arthritis30.2FCGR3B, SERPINB2, MMP8, CXCL6, IL1B, IL1A
9psoriatic arthritis30.1IL1B, IL1A
10psoriasis30.0DEFB4A, SERPINB2, IL1B, IL1A
11tuberculosis29.9DEFB4A, IL1B
12inflammatory bowel disease29.7DEFB4A, DEFB103B, DEFB1, IL1B
13funisitis10.5MMP8
14periapical granuloma10.5MMP8
15oral candidiasis10.4DEFB4A
16obesity10.4
17candidiasis10.4DEFB4A
18dental caries10.4
19osteoporosis10.4
20intervertebral disc disease10.4IL1B
21chronic ulcer of skin10.3DEFB4A, MMP8
22tonsillitis10.3DEFB1, DEFB4A
23endotheliitis10.3
24periodontosis10.3
25artery disease10.3
26middle ear cholesteatoma10.3DEFB4A, IL1A
27bacterial meningitis10.3MMP8, IL1B
28chorioamnionitis10.2MMP8, IL1B
29coronary artery disease10.2
30kidney disease10.2
31gingival overgrowth10.2IL1B, IL1A
32otitis media10.2DEFB1, IL1B
33acne10.2DEFB4A, DEFB1, IL1A
34synovitis10.2IL1A, IL1B, MMP8
35eclampsia10.2
36root caries10.2
37amyloidosis10.2
38pre-eclampsia10.2
39malaria10.1IL1A, IL1B
40sinusitis10.1CXCL6, DEFB4A
41thrombocytosis10.1IL1A, IL1B
42atopic dermatitis10.1DEFB4A, DEFB103B, IL1A
43cholesteatoma10.1IL1A, MMP8, DEFB1, DEFB4A
44gastritis10.1IL1B, DEFB1, DEFB4A
45chediak-higashi syndrome10.1
46myocardial infarction10.1
47scurvy10.1
48acute myocardial infarction10.1
49gingival recession10.1
50osteonecrosis10.1

Graphical network of the top 20 diseases related to Periodontal Disease:



Diseases related to periodontal disease

Symptoms for Periodontal Disease

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Drugs & Therapeutics for Periodontal Disease

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Drug clinical trials:

Search ClinicalTrials for Periodontal Disease

Search NIH Clinical Center for Periodontal Disease

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Periodontal Disease

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Anatomical Context for Periodontal Disease

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MalaCards organs/tissues related to Periodontal Disease:

31
Bone, Neutrophil, T cells, Heart, Endothelial, Kidney, Testes, Monocytes, Prostate, B cells, Cortex, Breast, Nk cells

Animal Models for Periodontal Disease or affiliated genes

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MGI Mouse Phenotypes related to Periodontal Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.8IL1A, IL1B, IL17F, CXCL6, MMP8, SERPINB2

Publications for Periodontal Disease

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Articles related to Periodontal Disease:

(show top 50)    (show all 866)
idTitleAuthorsYear
1
IL-33 Exacerbates Periodontal Disease through Induction of RANKL. (25808546)
2015
2
Cardiovascular Risks Associated with Incident and Prevalent Periodontal Disease. (25385537)
2014
3
Surgical treatment for patients with periodontal disease reduces risk of end-stage renal disease: a nationwide population-based retrospective cohort study. (23646848)
2014
4
Fluoxetine reduces periodontal disease progression in a conditioned fear stress model in rats. (23425324)
2013
5
Peripheral arterial disease associated with caries and periodontal disease. (22680302)
2013
6
Influence of periodontal disease on systemic disease: inversion of a paradigm: a review. (23904870)
2013
7
Periodontal disease: a covert source of inflammation in chronic kidney disease patients. (23840952)
2013
8
Periodontal disease and type 1 diabetes mellitus: associations with glycemic control and complications: an Indian perspective. (23680241)
2013
9
Impact of plasma of argon cleaning treatment on implant abutments in patients with a history of periodontal disease and thin biotype: radiographic results at 24-month follow-up of a RCT. (24191873)
2013
10
Aspirin intake: Can be a confounding factor in clinical trial for periodontal disease. (24302845)
2013
11
Orthodontic treatment for a patient with advanced periodontal disease: 11-year follow-up. (23992818)
2013
12
Change of periodontal disease status during and after pregnancy. (22873653)
2013
13
Association between periodontal disease and venous thromboembolic disease. (23757458)
2013
14
Phenotypic and genotypic features of Aggregatibacter actinomycetemcomitans isolated from patients with periodontal disease. (23391608)
2013
15
Lactoferrin, a marker for periodontal disease. (23432422)
2013
16
Periodontal disease and risk of psoriasis among nurses in the United States. (23374087)
2013
17
Diagnosis and management of vertical bony defects in periodontal disease. (22782040)
2012
18
CDC: Half of American adults have periodontal disease. (23256312)
2012
19
Direct recognition of Fusobacterium nucleatum by the NK cell natural cytotoxicity receptor NKp46 aggravates periodontal disease. (22457623)
2012
20
AHA statement on periodontal disease and heart disease. (22558948)
2012
21
Periodontal disease and decreased kidney function in Japanese elderly. (22001179)
2012
22
Letter to the editor: does periodontal disease cause amyloidosis? (22292602)
2012
23
Clinical indicators of periodontal disease in patients with coronary heart disease: a 10 years longitudinal study. (22173486)
2012
24
Association between volatile sulfur compounds and periodontal disease progression in elderly non-smokers. (21861638)
2012
25
Histamine modulates salivary secretion and diminishes the progression of periodontal disease in rat experimental periodontitis. (22261710)
2012
26
Periodontal disease decreases insulin sensitivity and insulin signaling. (22087804)
2012
27
Effect of periodontal treatment on glycosylated hemoglobin levels in elderly patients with periodontal disease and type 2 diabetes. (22040558)
2011
28
Photodynamic therapy reduces bone resorption and decreases inflammatory response in an experimental rat periodontal disease model. (21651385)
2011
29
Interaction between periodontal disease and systemic secondary amyloidosis: from inflammation to amyloidosis. (21043797)
2011
30
Relationship between saturated fatty acids and periodontal disease. (21505204)
2011
31
A clinical study of the relationship between diabetes mellitus and periodontal disease. (22368365)
2011
32
Serum placental growth factor, vascular endothelial growth factor, soluble vascular endothelial growth factor receptor-1 and -2 levels in periodontal disease, and adverse pregnancy outcomes. (21513467)
2011
33
Pediatric obesity and periodontal disease: a systematic review of the literature. (21716988)
2011
34
Study on maternal periodontal diseases of the relationships between porphyromonas gingivalis, serum pro-immflamatory mediators and preterm low birth weight]. (20077889)
2009
35
Polymorphism of genes encoding toll-like receptors and inflammatory cytokines in periodontal disease in the Japanese population. (18714935)
2008
36
Periodontal disease in patients from the original Kostmann family with severe congenital neutropenia. (16584360)
2006
37
Identification of epithelial auto-antigens associated with periodontal disease. (15654832)
2005
38
The potential role of interleukin-17 in the immunopathology of periodontal disease. (15811054)
2005
39
Analysis of FcgammaRIIIb genotype of periodontal disease in the Han nationality in China]. (16155708)
2005
40
The systemic immune response is more prominent than the mucosal immune response in the pathogenesis of periodontal disease. (12956653)
2003
41
Self-heat shock protein 60 induces tumour necrosis factor-alpha in monocyte-derived macrophage: possible role in chronic inflammatory periodontal disease. (11882035)
2002
42
GCF IL-1beta profiles in periodontal disease. (11846849)
2002
43
Chemokines in human periodontal disease tissues. (11472436)
2001
44
Aspartat aminotransferase--a marker of periodontal disease activity. (10402712)
1999
45
Cysteine protease inhibitory activity and levels of salivary cystatins in whole saliva of periodontally diseased patients. (10697800)
1999
46
Relevance of local Th2-type cytokine mRNA expression in immunocompetent infiltrates in inflamed gingival tissue to periodontal diseases. (9010272)
1997
47
Molecular and cellular mechanisms for periodontal diseases: role of Th1 and Th2 type cytokines in induction of mucosal inflammation. (9085220)
1997
48
Salivary levels of alpha 2-macroglobulin, alpha 1-antitrypsin, C-reactive protein, cathepsin G and elastase in humans with or without destructive periodontal disease. (8850655)
1995
49
Adhesion molecule expression in chronic inflammatory periodontal disease tissue. (7509385)
1994
50
Cysteine proteinases and inhibitors in inflammation: their role in periodontal disease. (8315571)
1993

Variations for Periodontal Disease

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Expression for genes affiliated with Periodontal Disease

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Search GEO for disease gene expression data for Periodontal Disease.

Pathways for genes affiliated with Periodontal Disease

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Pathways related to Periodontal Disease according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7IL1B, IL1A
29.7IL1A, IL1B
39.7IL1A, IL1B
49.7IL1A, IL1B
5
Show member pathways
IL-1 Signaling Pathway36
IL1-mediated signaling events36
9.7IL1A, IL1B
69.5FCGR3B, IL1B, IL1A
79.5IL1A, IL1B, FCGR3B
8
Show member pathways
9.4IL17F, CXCL6
9
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.4IL1A, IL1B, DEFB4A
109.4IL1A, IL1B, SERPINB2
119.1CXCL6, IL1B, IL1A
129.1CXCL6, IL1B, IL1A
13
Show member pathways
9.0IL1A, IL1B, IL17F, FCGR3B
14
Show member pathways
8.6DEFB1, DEFB103B, DEFA3, DEFB4A

Compounds for genes affiliated with Periodontal Disease

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Compounds related to Periodontal Disease according to GeneCards Suite gene sharing:

(show all 47)
idCompoundScoreTop Affiliating Genes
1ciprofloxacin43 49 1212.2DEFB1, IL1A
2hydroxamate4310.2SERPINB2, MMP8
3muramyl tripeptide4310.1IL1B, IL1A
4tenidap43 2811.1IL1A, IL1B
5clodronate43 49 1212.1MMP8, IL1B
6git 275910.1IL1A, IL1B
74-ipp5910.1IL1A, IL1B
8gold sodium thiomalate4310.1IL1A, IL1B
9aacocf34310.1IL1A, IL1B
10pirfenidone43 5911.1IL1B, IL1A
11auranofin28 43 59 1213.1IL1B, IL1A
12naproxen43 24 1212.1IL1B, IL1A
13helenalin4310.1IL1B, DEFB4A
14as 10143 5911.0IL1A, IL1B
15minocycline43 1211.0IL1A, IL1B
16flagellin43 2811.0DEFB4A, IL1B
17gm-csf43 2811.0IL1B, IL1A
18grobeta4310.0IL1A, CXCL6
19lipoteichoic acid439.9IL1B, DEFB4A
20polymyxin b439.9IL1A, IL1B, DEFB1
21sulfasalazine28 43 49 1212.9IL1A, IL1B
22leukotriene b443 59 2411.9FCGR3B, IL1B, IL1A
23ns 39843 5910.8IL1A, IL1B
24polyinosinic-polycytidylic acid439.8IL1A, IL1B
25mg 13243 5910.8DEFB4A, IL1B, IL1A
26fmlp439.8IL1A, IL1B, FCGR3B
27il 10439.7IL1A, IL1B
28etanercept43 49 1211.7FCGR3B, IL1B
29h2o2439.6IL1A, MMP8, SERPINB2, FCGR3B
30ribonucleic acid439.6IL1A, IL1B, SERPINB2
31superoxide43 2410.6FCGR3B, SERPINB2, MMP8, IL1B
32sb 20358043 5910.5DEFB4A, IL1B, IL1A
33pge2439.5SERPINB2, MMP8, IL1B, IL1A
34groalpha439.5CXCL6, IL1B, IL1A
35heparin43 28 24 1212.5DEFB4A, CFHR1, SERPINB2, IL1A
36endotoxin439.5IL1A, IL1B, SERPINB2, DEFB4A
37genistein43 28 59 2 24 1214.3DEFB4A, FCGR3B, MMP8, IL1B, IL1A
38anti-fungal439.2DEFB103B, DEFA3, DEFB4A
39progesterone43 28 59 24 1213.2IL1A, MMP8, SERPINB2, DEFB103B, DEFB4A
40nitric oxide43 24 1211.1SERPINB2, MMP8, IL1B, IL1A
41retinoic acid43 2410.0DEFB4A, DEFB1, SERPINB2, MMP8, IL1B, IL1A
42rantes439.0DEFB4A, DEFB1, CXCL6, IL1B, IL1A
43vegf438.9SERPINB2, MMP8, CXCL6, IL1B, IL1A
44dexamethasone43 49 28 1211.7DEFB4A, DEFB103B, DEFB1, SERPINB2, IL1B, IL1A
45hbd2438.5IL1B, DEFB1, DEFB103B, DEFA3, DEFB4A
46calcium43 49 24 1211.4CXCL6, MMP8, SERPINB2, FCGR3B, DEFB103B, DEFB4A
47serine438.4IL1A, CXCL6, MMP8, SERPINB2, FCGR3B

GO Terms for genes affiliated with Periodontal Disease

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Cellular components related to Periodontal Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00057969.1DEFB1, DEFA3, DEFB4A
2extracellular spaceGO:00056156.6DEFA3, CFHR1, SERPINB2, MMP8, CXCL6, IL17F
3extracellular regionGO:00055766.3IL1A, DEFB4A, DEFA3, DEFB1, FCGR3B, SERPINB2

Biological processes related to Periodontal Disease according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1fever generationGO:00016609.9IL1B, IL1A
2ectopic germ cell programmed cell deathGO:00352349.9IL1A, IL1B
3positive regulation of interleukin-2 biosynthetic processGO:00450869.8IL1A, IL1B
4positive regulation vascular endothelial growth factor productionGO:00105759.8IL1A, IL1B
5positive regulation of mitosisGO:00458409.7IL1B, IL1A
6positive regulation of cell divisionGO:00517819.7IL1A, IL1B
7negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012409.6IL1A, IL1B
8chemotaxisGO:00069359.4DEFB4A, DEFB1, CXCL6
9extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.4IL1A, IL1B
10inflammatory responseGO:00069548.9IL1A, IL1B, IL17F, CXCL6
11immune responseGO:00069558.5IL1A, IL1B, CXCL6, FCGR3B, DEFB1, DEFB4A

Molecular functions related to Periodontal Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00051499.4IL1A, IL1B
2cytokine activityGO:00051259.3IL1A, IL1B, IL17F

Products for genes affiliated with Periodontal Disease

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  • Antibodies
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Sources for Periodontal Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet