MCID: PRD007
MIFTS: 61

Periodontal Disease malady

Gastrointestinal diseases, Oral diseases categories

Summaries for Periodontal Disease

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63Wikipedia, 32MalaCards
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Wikipedia:63 Periodontal pathology, or periodontal diseases, are a group of diseases which affects one or more of the... more...

MalaCards: Periodontal Disease, also known as periodontal diseases, is related to periodontitis and gingivitis. An important gene associated with Periodontal Disease is MMP8 (matrix metallopeptidase 8 (neutrophil collagenase)), and among its related pathways are Immune System and PEDF Induced Signaling. The drugs chlorhexidine and chlorhexidine gluconate and the compounds calcium and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and kidney, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Periodontal Disease

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Oral diseases


Aliases & Descriptions:

periodontal disease 8 10
periodontal diseases 44 60
disease of supporting structures of teeth, nos 8
periodontium disorder 8


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Disease Ontology8 DOID:3388
MeSH34 D010510
NCIt39 C63743
ICD1025 K05.6

Related Diseases for Periodontal Disease

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17GeneCards, 18GeneDecks
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Diseases related to Periodontal Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 231)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis32.0MMP8, IL1B, TNFRSF11B, IL1A
2gingivitis31.3TNFRSF11B, CTSG, GUSB, IL1A, IL1B, IL17A
3diabetes mellitus30.9IL1B, CD79A
4arthritis30.8TNFSF11, CTSG, IL1A, IL1B, IL17A
5rheumatoid arthritis30.7CTSG, TNFRSF11B, TNFSF11, CCL20, GUSB, CD79A
6obesity30.6IL17A
7dental caries30.6CD79A, MMP8
8osteoporosis30.6TNFSF11, TNFRSF11B, IL11, MMP13, MMP8
9vascular disease30.5IL1A, IL1B, ELANE
10aggressive periodontitis30.5IL1A, MMP8
11atherosclerosis30.5CAMP, TNFRSF11B, IL1A, IL1B, IL17A, MMP13
12hypertension30.4CD79A
13bacterial vaginosis30.3IL1B, IL1A
14coronary artery disease30.3TNFSF11, TNFRSF11B, IL17A, MMP13
15psoriasis30.1IL1A, IL1B, IL17A, SERPINB2, ELANE, IL11
16squamous cell carcinoma30.1KLK11, CAMP, CTSG, DEFB1, DEFB4A, MMP13
17myocardial infarction30.1SERPINB2, MMP13, IL11
18acute myocardial infarction30.1TNFSF11, MMP8
19root resorption30.1TNFRSF11B
20inflammatory bowel disease29.9GUSB, DEFB1, DEFB103B, DEFB4A, IL11, IL1B
21breast cancer29.8KLK11, CAMP, TNFSF11, TNFRSF11B, IL11, IL17A
22tuberculosis29.8CAMP, CTSG, GUSB, DEFB4A, CD79A, IL11
23psoriatic arthritis29.8TNFSF11, TNFRSF11B, IL1A, IL1B
24glomerulonephritis29.8CTSG, CD79A, IL1B, ELANE
25neutropenia29.8ELANE, IL11
26lupus erythematosus29.8CD79A
27prostatitis29.8CD79A
28pulmonary emphysema29.8CTSG, MMP8, ELANE
29systemic lupus erythematosus29.8IL17A, CD79A, GUSB, CTSG
30gingival disease10.8
31tooth disease10.5
32bone resorption disease10.4
33type 2 diabetes mellitus10.3
34kidney disease10.3
35leukocyte disease10.3
36periodontosis10.3
37type 1 diabetes mellitus10.2
38bone inflammation disease10.2
39eclampsia10.1
40root caries10.1
41amyloidosis10.1
42collagen disease10.1
43pre-eclampsia10.1
44peripheral vascular disease10.1
45chediak-higashi syndrome10.1
46gingival recession10.1
47gestational diabetes10.1
48hypophosphatasia10.1
49scurvy10.1
50bone remodeling disease10.1

Graphical network of the top 20 diseases related to Periodontal Disease:



Diseases related to periodontal disease

Clinical Features for Periodontal Disease

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Drugs & Therapeutics for Periodontal Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Periodontal Disease

Drug clinical trials:

Search ClinicalTrials for Periodontal Disease

Search NIH Clinical Center for Periodontal Disease

Search CenterWatch for Periodontal Disease

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Periodontal Disease

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Anatomical Context for Periodontal Disease

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32MalaCards
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MalaCards organs/tissues related to Periodontal Disease:

32
Bone, Heart, Kidney, T cells, Endothelial, Monocytes, Testes, B cells, Prostate, Breast, Nk cells, Cortex

Animal Models for Periodontal Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Periodontal Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539711.0TNFRSF11B, CTSG, GUSB, CD79A, IL1A, IL17A
2MP:000538710.9ELANE, CAMP, TNFSF11, TNFRSF11B, CTSG, DEFB1

Publications for Periodontal Disease

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50PubMed
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Articles related to Periodontal Disease:

(show top 50)    (show all 937)
idTitleAuthorsYear
1
Influence of periodontal disease on systemic disease: inversion of a paradigm: a review. (23904870)
2013
2
Adverse pregnancy outcomes (APOs) and periodontal disease: pathogenic mechanisms. (23627327)
2013
3
Accuracy of Self-Reported Periodontal Disease in the Women's Health Initiative Observational Study. (24354649)
2013
4
Periodontal disease in habitual cigarette smokers and nonsmokers with and without prediabetes. (22688499)
2013
5
Salivary MMPs, TIMPs, and MPO levels in periodontal disease patients and controls. (23501330)
2013
6
Lactoferrin knockout mice demonstrates greater susceptibility to Aggregatibacter actinomycetemcomitans-induced periodontal disease. (23327622)
2013
7
Periodontal disease and atherosclerotic cardiovascular disease. (23385221)
2013
8
Periodontal disease, hypertension, and blood pressure among older adults in Puerto Rico. (22548584)
2013
9
Drug addiction and periodontal diseases. (24174750)
2013
10
Role of insulin sensitivity and beta cell function in the development of periodontal disease in adults without diabetes. (24192072)
2013
11
Salivary nitric oxide levels in inflammatory periodontal disease - a case-control and interventional study. (21564536)
2012
12
Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis. (22576262)
2012
13
Acetylcholine and the alpha 7 nicotinic receptor: a potential therapeutic target for the treatment of periodontal disease? (22777144)
2012
14
Periodontal disease is significantly higher in non-smoking treatment-naive rheumatoid arthritis patients: results from a case-control study. (22875903)
2012
15
Estimation of matrix metalloproteinase-3 levels in gingival crevicular fluid in periodontal disease, health and after scaling and root planing. (23493467)
2012
16
Chronic periodontal disease may influence the pulp sensitivity response: clinical evaluation in consecutive patients. (22577567)
2012
17
The relationship between periodontal disease severity and state-trait anxiety level. (23866479)
2012
18
Association between polymorphisms in interleukin-17A and -17F genes and chronic periodontal disease. (23304063)
2012
19
Association between periodontal disease and stroke. (22244863)
2012
20
Researchers: how porphyromonas gingivalis contributes to periodontal disease identified. (22303556)
2012
21
Effectiveness of egg yolk immunoglobulin (IgY) against periodontal disease-causing Fusobacterium nucleatum. (22789022)
2012
22
Interaction between periodontal disease and systemic secondary amyloidosis: from inflammation to amyloidosis. (21043797)
2011
23
Assessment of knowledge toward periodontal disease among a sample of nephrologists and nurses who work with chronic kidney disease not yet on dialysis. (22189806)
2011
24
Langerhans cells in periodontal disease of HIV- and HIV+ patients undergoing highly active antiretroviral therapy. (21670857)
2011
25
No association between periodontal disease and GHQ-12 in a Brazilian Police population. (21743420)
2011
26
Periodontal disease and nitric oxide levels in low risk women with preterm labor. (21621901)
2011
27
Periodontal disease as a risk factor for cardiovascular disease: suggestion of a further link in systemic lupus erythematosus. (21601991)
2011
28
Association between Human Body Composition and Periodontal Disease. (22111011)
2011
29
Periodontal disease and hypertension: the pre-eclampsia model in Hispanic population. (21475049)
2011
30
Latin America: native populations affected by early onset periodontal disease. (21823496)
2011
31
Bidirectional relationship between diabetes and periodontal disease: review of evidence. (21381588)
2010
32
Association between periodontal disease, bacterial vaginosis, and sexual risk behaviours. (20636412)
2010
33
Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis. (19214202)
2009
34
Polymorphism of genes encoding toll-like receptors and inflammatory cytokines in periodontal disease in the Japanese population. (18714935)
2008
35
CXCL13 expression and follicular dendritic cells in relation to B-cell infiltration in periodontal disease tissues. (18624951)
2008
36
Interleukin-6 -174 genotype, periodontal disease and adverse pregnancy outcomes: a pilot study. (18181010)
2008
37
Association of interleukin-1 polymorphisms with periodontal disease. (15974847)
2005
38
CXCL12 and CXCR4 expression by human gingival fibroblasts in periodontal disease. (16045736)
2005
39
The systemic immune response is more prominent than the mucosal immune response in the pathogenesis of periodontal disease. (12956653)
2003
40
Macrophage inflammatory protein 3alpha-CC chemokine receptor 6 interactions play an important role in CD4+ T-cell accumulation in periodontal diseased tissue. (12067311)
2002
41
Candidate genes as potential links between periodontal and cardiovascular diseases. (11887471)
2001
42
Features of severe periodontal disease in a teenager with ChAcdiak-Higashi syndrome. (10872965)
2000
43
Polymorphism of the N-acetyltransferase (NAT2), smoking and the potential risk of periodontal disease. (11005681)
2000
44
Calprotectin in gingival crevicular fluid correlates with clinical and biochemical markers of periodontal disease. (10522776)
1999
45
Factors for progression of periodontal diseases. (9563800)
1998
46
Interleukin-1beta+3953 allele 2: association with disease status in adult periodontitis. (9797049)
1998
47
CD29 expression on CD4+ gingival lymphocytes supports migration of activated memory T lymphocytes to diseased periodontal tissue. (9467397)
1997
48
A multi-center clinical trial of a new chairside test in distinguishing between diseased and healthy periodontal sites. II. Association between site type and test outcome before and after therapy. (8794969)
1996
49
Medical status and complications in relation to periodontal disease experience in insulin-dependent diabetics. (8707978)
1996
50
Changes of factors on disease activity in advancing periodontitis]. (2135609)
1990

Genetic Variations for Periodontal Disease

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Expression for genes affiliated with Periodontal Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Periodontal Disease

Search GEO for disease gene expression data for Periodontal Disease.

Pathways for genes affiliated with Periodontal Disease

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Sources:
53Reactome, 51QIAGEN, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Periodontal Disease according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8DEFB1, DEFB103B, DEFB4A, CD79A, IL1A, IL1B
2
Hide members
10.8CCL20, TNFSF11, TNFRSF11B, IL11, IL1A, IL17A
3
Hide members
10.8TNFSF11, IL11, IL1A, IL1B, CCL20
4
Hide members
10.8CCL20, TNFSF11, IL11, IL1A, IL1B
5
Hide members
10.7TNFSF11, TNFRSF11B, IL1A, IL1B
610.7TNFSF11, TNFRSF11B, IL1A, IL1B
7
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.7IL1B, IL1A, TNFRSF11B, TNFSF11
8
Immune response Bacterial infections in normal airways
Hide members
10.7CCL20, DEFB4A, IL1A, IL1B
9
Hide members
10.7IL17A, IL1B, IL1A, CD79A
10
Hide members
10.7KLK11, CTSG, MMP13, MMP8
1110.7ELANE, MMP8, CTSG
12
Hide members
10.7CTSG, MMP13, MMP8
13
Hide members
10.7DEFB4A, DEFB103B, DEFB1
1410.7IL1B, IL1A, IL11
1510.7IL11, TNFSF11, CCL20
1610.6IL1A, IL1B
1710.6TNFRSF11B, TNFSF11

Compounds for genes affiliated with Periodontal Disease

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Periodontal Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2414.7CAMP, DEFB4A, KLK11, CCL20, TNFSF11, SERPINB2
2retinoic acid44 2412.7ELANE, TNFRSF11B, CTSG, DEFB1, DEFB4A, CD79A
3heparin44 28 11 2414.6ELANE, CTSG, SERPINB2, MMP13, IL1A, IL11
4nitric oxide44 11 2413.6SERPINB2, CCL20, IL11, IL1A, IL1B, IL17A
5vegf4411.6MMP13, CD79A, IL1A, IL1B, SERPINB2, IL17A
6cysteine4411.6CD79A, DEFB4A, DEFB103B, CTSG, TNFRSF11B, HTN3
7dexamethasone44 49 28 1114.5CD79A, SERPINB2, CCL20, CAMP, TNFSF11, DEFB1
8steroid4411.5CAMP, CD79A, KLK11, IL11, IL17A, TNFRSF11B
9genistein44 28 59 2 11 2416.4IL1B, MMP8, MMP13, IL1A, GUSB, TNFSF11
10cyclosporin a44 28 5913.4MMP8, SERPINB2, ELANE, IL17A, IL11, TNFRSF11B
11prostaglandin4411.4MMP13, IL17A, IL1B, IL1A, IL11, TNFRSF11B
12fibrinogen4411.3TNFRSF11B, CTSG, IL11, ELANE, SERPINB2, MMP8
13rantes4411.3IL1B, CCL20, DEFB4A, IL17A, IL1A, IL11
14endotoxin4411.3CAMP, CCL20, CTSG, DEFB4A, IL11, SERPINB2
15polymyxin b4411.3CAMP, TNFSF11, TNFRSF11B, DEFB1, IL1A, IL1B
16sb 20358044 5912.3MMP13, TNFRSF11B, IL1B, IL17A, IL1A, DEFB4A
17vitamin d4411.2ELANE, IL1A, IL11, CD79A, TNFRSF11B, TNFSF11
18progesterone44 59 28 11 2415.2SERPINB2, MMP8, DEFB4A, IL1A, IL11, CAMP
19histamine44 28 2413.2IL11, CTSG, DEFB4A, CD79A, IL1B, CAMP
20aprotinin44 1112.2IL1A, KLK11, CTSG, ELANE, SERPINB2, MMP13
21leukotriene b444 59 2413.2CTSG, GUSB, IL11, ELANE, IL1B, IL1A
22serine4411.2MMP13, CAMP, MMP8, IL1A, CTSG, TNFRSF11B
23hbd24411.2CAMP, DEFB4A, DEFB1, DEFB103B, IL1B
24clodronate44 49 1113.2MMP8, TNFSF11, MMP13, IL1B, TNFRSF11B
25hyaluronic acid44 2412.2CD79A, IL1A, IL1B, MMP13, ELANE, IL11
26alendronate44 49 1113.2TNFSF11, MMP8, MMP13, IL11, TNFRSF11B
27ns 39844 5912.2TNFRSF11B, IL17A, IL1B, IL1A, TNFSF11
28etanercept44 49 1113.2TNFSF11, TNFRSF11B, IL11, IL1B, IL17A
29fmlp4411.1GUSB, CAMP, CTSG, IL1A, IL1B, ELANE
30infliximab44 49 1113.1IL11, IL1B, IL17A, TNFRSF11B, TNFSF11
31peptidoglycan44 2812.1CCL20, CTSG, TNFSF11, DEFB4A, IL1B
32arachidonic acid44 28 11 2414.1TNFRSF11B, TNFSF11, CAMP, CTSG, IL11, IL1B
33doxycycline44 1112.1MMP8, TNFSF11, ELANE, MMP13, CD79A
34calcitriol44 59 11 2414.1IL1B, IL1A, IL11, TNFRSF11B, TNFSF11, CAMP
35(4-aminophenyl)mercuric acetate4411.1CTSG, MMP13, MMP8, ELANE
36hydroxyapatite4411.1MMP13, IL11, HTN3, TNFRSF11B, TNFSF11
37aspirin44 49 28 2414.0CTSG, GUSB, IL1B, TNFRSF11B, ELANE, CD79A
38pmma4411.0CD79A, HTN3, TNFRSF11B, TNFSF11
39estrogen4411.0DEFB4A, CD79A
40indomethacin44 59 28 1114.0CTSG
41sp 60012544 5912.0MMP13, IL17A, DEFB4A, TNFSF11, IL1B
42cycloheximide4410.9CTSG, SERPINB2
43superoxide44 2411.9ELANE, SERPINB2, GUSB, MMP8, IL1B
44groalpha4410.9IL1B, IL1A, MMP13, IL17A
45sodium dodecylsulfate4410.8HTN3, CD79A, ELANE, IL1A, CTSG
46forskolin44 49 1112.8CAMP, IL11
47p0024410.8MMP8, DEFB4A, MMP13, IL17A, TNFRSF11B
481,25 dihydroxy vitamin d34410.7TNFSF11, IL11, TNFRSF11B
49thymidine44 2411.6MMP13, IL17A, IL1B, IL1A, IL11, CTSG
50gm-csf44 2811.4IL11

GO Terms for genes affiliated with Periodontal Disease

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Sources:
16Gene Ontology
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Cellular components related to Periodontal Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.3ELANE, KLK11, CCL20, CAMP, TNFSF11, TNFRSF11B
2extracellular spaceGO:00561510.8CCL20, TNFSF11, TNFRSF11B, CTSG, IL11, IL1A
3secretory granuleGO:03014110.7ELANE, IL1B, CTSG

Biological processes related to Periodontal Disease according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.2IL17A, CCL20, TNFSF11, CTSG, DEFB1, DEFB4A
2defense response to bacteriumGO:04274211.0CCL20, CAMP, HTN3, DEFB1, DEFB4A
3extracellular matrix organizationGO:03019811.0TNFRSF11B, CTSG, MMP13, MMP8, ELANE
4extracellular matrix disassemblyGO:02261710.9ELANE, MMP8, MMP13, CTSG
5proteolysisGO:00650810.8ELANE, MMP8, MMP13, CTSG, KLK11
6fever generationGO:00166010.7IL1A, IL1B
7inflammatory responseGO:00695410.7IL17A, IL1B, IL1A, CCL20
8positive regulation of immune responseGO:05077810.7ELANE, CTSG
9collagen catabolic processGO:03057410.7MMP13, MMP8, ELANE
10cell-cell signalingGO:00726710.6IL17A, IL1B, IL11, CCL20
11positive regulation of interleukin-2 biosynthetic processGO:04508610.3IL1A, IL1B

Molecular functions related to Periodontal Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.7IL17A, IL1B, IL1A, IL11, TNFRSF11B, TNFSF11
2interleukin-1 receptor bindingGO:00514910.6IL1B, IL1A
3serine-type endopeptidase activityGO:00425210.4KLK11, CTSG, MMP8, ELANE

Products for genes affiliated with Periodontal Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Periodontal Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet