MCID: PRD007
MIFTS: 55

Periodontal Disease malady

Gastrointestinal diseases, Oral diseases categories
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Summaries for Periodontal Disease

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65Wikipedia, 33MalaCards
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Wikipedia:65 Periodontal pathology, or periodontal diseases, are a group of diseases which affects one or more of the... more...

MalaCards: Periodontal Disease, also known as periodontal diseases, is related to periodontitis and gingivitis. An important gene associated with Periodontal Disease is MMP8 (matrix metallopeptidase 8 (neutrophil collagenase)), and among its related pathways are Cytokine Network and Cytokines and Inflammatory Response. The drugs chlorhexidine and chlorhexidine gluconate and the compounds ciprofloxacin and hydroxamate have been mentioned in the context of this disorder. Affiliated tissues include bone, t cells and endothelial, and related mouse phenotype immune system.

Aliases & Classifications for Periodontal Disease

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Oral diseases


Aliases & Descriptions:

periodontal disease 8 10
periodontal diseases 45 62
disease of supporting structures of teeth, nos 8
periodontium disorder 8


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Disease Ontology8 DOID:3388
NCIt40 C63743
MeSH35 D010510
ICD1025 K05.6

Related Diseases for Periodontal Disease

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17GeneCards, 18GeneDecks
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Diseases related to Periodontal Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis32.1MMP8, IL1B, IL1A
2gingivitis31.2IL1A, IL1B, MMP8, SERPINB2
3arthritis30.8IL1A, IL1B
4aggressive periodontitis30.6IL1A, MMP8
5rheumatoid arthritis30.5FCGR3B, SERPINB2, MMP8, CXCL6, IL1B, IL1A
6atherosclerosis30.4SERPINB2, MMP8, IL1B, IL1A
7bacterial vaginosis30.4IL1B, IL1A
8psoriasis30.0DEFB4A, SERPINB2, IL1B, IL1A
9psoriatic arthritis29.9IL1B, IL1A
10tuberculosis29.8DEFB4A, IL1B
11inflammatory bowel disease29.8DEFB4A, DEFB103B, DEFB1, IL1B
12diabetes mellitus10.6
13obesity10.4
14dental caries10.4
15osteoporosis10.4
16endotheliitis10.3
17periodontosis10.2
18artery disease10.2
19hypertension10.2
20type 2 diabetes mellitus10.2
21coronary artery disease10.2
22type 1 diabetes mellitus10.2
23kidney disease10.2
24eclampsia10.1
25root caries10.1
26amyloidosis10.1
27pre-eclampsia10.1
28funisitis10.1MMP8
29periapical granuloma10.1MMP8
30oral candidiasis10.1DEFB4A
31candidiasis10.1DEFB4A
32degenerative disc disease10.1IL1B
33tonsillitis10.1DEFB1, DEFB4A
34middle ear cholesteatoma10.1DEFB4A, IL1A
35bacterial meningitis10.1MMP8, IL1B
36chorioamnionitis10.1MMP8, IL1B
37duodenal ulcer10.1DEFB1, DEFB4A
38gingival overgrowth10.0IL1B, IL1A
39otitis media10.0DEFB1, IL1B
40chediak-higashi syndrome10.0
41gingival recession10.0
42scurvy10.0
43hypophosphatasia10.0
44root resorption10.0
45acute myocardial infarction10.0
46cervicitis10.0
47myocardial infarction10.0
48vascular disease10.0
49synovitis10.0IL1A, IL1B, MMP8
50cerebral malaria10.0IL1A, IL1B

Graphical network of the top 20 diseases related to Periodontal Disease:



Diseases related to periodontal disease

Symptoms for Periodontal Disease

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Drugs & Therapeutics for Periodontal Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Periodontal Disease

Search NIH Clinical Center for Periodontal Disease

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Periodontal Disease

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Anatomical Context for Periodontal Disease

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33MalaCards
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MalaCards organs/tissues related to Periodontal Disease:

33
Bone, T cells, Endothelial, Kidney, Heart, Monocytes, Testes, Prostate, B cells, Breast, Nk cells, Cortex

Animal Models for Periodontal Disease or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Periodontal Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.8IL1A, IL1B, IL17F, CXCL6, MMP8, SERPINB2

Publications for Periodontal Disease

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Sources:
52PubMed
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Articles related to Periodontal Disease:

(show top 50)    (show all 825)
idTitleAuthorsYear
1
Surgical treatment for patients with periodontal disease reduces risk of end-stage renal disease: a nationwide population-based retrospective cohort study. (23646848)
2014
2
Fluoxetine reduces periodontal disease progression in a conditioned fear stress model in rats. (23425324)
2013
3
Peripheral arterial disease associated with caries and periodontal disease. (22680302)
2013
4
Influence of periodontal disease on systemic disease: inversion of a paradigm: a review. (23904870)
2013
5
Periodontal disease: a covert source of inflammation in chronic kidney disease patients. (23840952)
2013
6
Periodontal disease and type 1 diabetes mellitus: associations with glycemic control and complications: an Indian perspective. (23680241)
2013
7
Impact of plasma of argon cleaning treatment on implant abutments in patients with a history of periodontal disease and thin biotype: radiographic results at 24-month follow-up of a RCT. (24191873)
2013
8
Aspirin intake: Can be a confounding factor in clinical trial for periodontal disease. (24302845)
2013
9
Orthodontic treatment for a patient with advanced periodontal disease: 11-year follow-up. (23992818)
2013
10
Change of periodontal disease status during and after pregnancy. (22873653)
2013
11
Association between periodontal disease and venous thromboembolic disease. (23757458)
2013
12
Phenotypic and genotypic features of Aggregatibacter actinomycetemcomitans isolated from patients with periodontal disease. (23391608)
2013
13
Lactoferrin, a marker for periodontal disease. (23432422)
2013
14
Periodontal disease and risk of psoriasis among nurses in the United States. (23374087)
2013
15
Periodontal disease is an independent predictor of intracardiac calcification. (24106721)
2013
16
Diazepam reverses the alveolar bone loss and hippocampal interleukin-1beta and interleukin-6 enhanced by conditioned fear stress in ligature-induced periodontal disease in rats. (22891744)
2013
17
Diagnosis and management of vertical bony defects in periodontal disease. (22782040)
2012
18
CDC: Half of American adults have periodontal disease. (23256312)
2012
19
Direct recognition of Fusobacterium nucleatum by the NK cell natural cytotoxicity receptor NKp46 aggravates periodontal disease. (22457623)
2012
20
AHA statement on periodontal disease and heart disease. (22558948)
2012
21
Periodontal disease and decreased kidney function in Japanese elderly. (22001179)
2012
22
Letter to the editor: does periodontal disease cause amyloidosis? (22292602)
2012
23
Association between volatile sulfur compounds and periodontal disease progression in elderly non-smokers. (21861638)
2012
24
Histamine modulates salivary secretion and diminishes the progression of periodontal disease in rat experimental periodontitis. (22261710)
2012
25
Periodontal disease decreases insulin sensitivity and insulin signaling. (22087804)
2012
26
Effect of periodontal treatment on glycosylated hemoglobin levels in elderly patients with periodontal disease and type 2 diabetes. (22040558)
2011
27
Photodynamic therapy reduces bone resorption and decreases inflammatory response in an experimental rat periodontal disease model. (21651385)
2011
28
Interaction between periodontal disease and systemic secondary amyloidosis: from inflammation to amyloidosis. (21043797)
2011
29
Relationship between saturated fatty acids and periodontal disease. (21505204)
2011
30
A clinical study of the relationship between diabetes mellitus and periodontal disease. (22368365)
2011
31
Serum placental growth factor, vascular endothelial growth factor, soluble vascular endothelial growth factor receptor-1 and -2 levels in periodontal disease, and adverse pregnancy outcomes. (21513467)
2011
32
Pediatric obesity and periodontal disease: a systematic review of the literature. (21716988)
2011
33
Study on maternal periodontal diseases of the relationships between porphyromonas gingivalis, serum pro-immflamatory mediators and preterm low birth weight]. (20077889)
2009
34
Polymorphism of genes encoding toll-like receptors and inflammatory cytokines in periodontal disease in the Japanese population. (18714935)
2008
35
Periodontal disease in patients from the original Kostmann family with severe congenital neutropenia. (16584360)
2006
36
Identification of epithelial auto-antigens associated with periodontal disease. (15654832)
2005
37
The potential role of interleukin-17 in the immunopathology of periodontal disease. (15811054)
2005
38
Analysis of FcgammaRIIIb genotype of periodontal disease in the Han nationality in China]. (16155708)
2005
39
The systemic immune response is more prominent than the mucosal immune response in the pathogenesis of periodontal disease. (12956653)
2003
40
Self-heat shock protein 60 induces tumour necrosis factor-alpha in monocyte-derived macrophage: possible role in chronic inflammatory periodontal disease. (11882035)
2002
41
GCF IL-1beta profiles in periodontal disease. (11846849)
2002
42
Chemokines in human periodontal disease tissues. (11472436)
2001
43
Infection-mediated early-onset periodontal disease in P/E-selectin-deficient mice. (11350525)
2001
44
Aspartat aminotransferase--a marker of periodontal disease activity. (10402712)
1999
45
Cysteine protease inhibitory activity and levels of salivary cystatins in whole saliva of periodontally diseased patients. (10697800)
1999
46
Relevance of local Th2-type cytokine mRNA expression in immunocompetent infiltrates in inflamed gingival tissue to periodontal diseases. (9010272)
1997
47
Molecular and cellular mechanisms for periodontal diseases: role of Th1 and Th2 type cytokines in induction of mucosal inflammation. (9085220)
1997
48
Salivary levels of alpha 2-macroglobulin, alpha 1-antitrypsin, C-reactive protein, cathepsin G and elastase in humans with or without destructive periodontal disease. (8850655)
1995
49
Adhesion molecule expression in chronic inflammatory periodontal disease tissue. (7509385)
1994
50
Cysteine proteinases and inhibitors in inflammation: their role in periodontal disease. (8315571)
1993

Variations for Periodontal Disease

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Expression for genes affiliated with Periodontal Disease

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Periodontal Disease

Search GEO for disease gene expression data for Periodontal Disease.

Pathways for genes affiliated with Periodontal Disease

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Sources:
50PathCards, 53QIAGEN, 38NCBI BioSystems Database, 30KEGG, 55Reactome, 60Thomson Reuters, 12EMD Millipore
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Pathways related to Periodontal Disease according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7IL1B, IL1A
29.7IL1A, IL1B
39.7IL1A, IL1B
49.7IL1A, IL1B
5
Show member pathways
IL-1 Signaling Pathway38
IL1-mediated signaling events38
9.7IL1A, IL1B
69.5FCGR3B, IL1B, IL1A
79.5IL1A, IL1B, FCGR3B
8
Show member pathways
9.4IL17F, CXCL6
99.4MMP8, DEFA3
10
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.4IL1A, IL1B, DEFB4A
119.4IL1A, IL1B, SERPINB2
129.1CXCL6, IL1B, IL1A
139.1CXCL6, IL1B, IL1A
14
Show member pathways
9.0IL1A, IL1B, IL17F, FCGR3B
15
Show member pathways
8.6DEFB1, DEFB103B, DEFA3, DEFB4A

Compounds for genes affiliated with Periodontal Disease

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 24HMDB, 3BitterDB
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Compounds related to Periodontal Disease according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1ciprofloxacin45 51 1112.2DEFB1, IL1A
2hydroxamate4510.2SERPINB2, MMP8
3muramyl tripeptide4510.1IL1B, IL1A
4tenidap45 2911.1IL1A, IL1B
5clodronate45 51 1112.1MMP8, IL1B
6git 276110.1IL1A, IL1B
74-ipp6110.1IL1A, IL1B
8gold sodium thiomalate4510.1IL1A, IL1B
9aacocf34510.1IL1A, IL1B
10pirfenidone45 6111.1IL1B, IL1A
11auranofin29 45 61 1113.1IL1B, IL1A
12naproxen45 24 1112.1IL1B, IL1A
13helenalin4510.1IL1B, DEFB4A
14as 10145 6111.0IL1A, IL1B
15minocycline45 1111.0IL1A, IL1B
16flagellin45 2911.0DEFB4A, IL1B
17gm-csf45 2911.0IL1B, IL1A
18grobeta4510.0IL1A, CXCL6
19lipoteichoic acid459.9IL1B, DEFB4A
20polymyxin b459.9IL1A, IL1B, DEFB1
21sulfasalazine29 45 51 1112.9IL1A, IL1B
22leukotriene b445 61 2411.9FCGR3B, IL1B, IL1A
23ns 39845 6110.8IL1A, IL1B
24polyinosinic-polycytidylic acid459.8IL1A, IL1B
25mg 13245 6110.8DEFB4A, IL1B, IL1A
26fmlp459.8IL1A, IL1B, FCGR3B
27il 10459.7IL1A, IL1B
28etanercept45 51 1111.7FCGR3B, IL1B
29h2o2459.6IL1A, MMP8, SERPINB2, FCGR3B
30ribonucleic acid459.6IL1A, IL1B, SERPINB2
31superoxide45 2410.6FCGR3B, SERPINB2, MMP8, IL1B
32sb 20358045 6110.5DEFB4A, IL1B, IL1A
33pge2459.5SERPINB2, MMP8, IL1B, IL1A
34groalpha459.5CXCL6, IL1B, IL1A
35heparin45 29 24 1112.5DEFB4A, CFHR1, SERPINB2, IL1A
36endotoxin459.5IL1A, IL1B, SERPINB2, DEFB4A
37genistein45 29 61 3 24 1114.3DEFB4A, FCGR3B, MMP8, IL1B, IL1A
38anti-fungal459.2DEFB103B, DEFA3, DEFB4A
39progesterone45 29 61 24 1113.2IL1A, MMP8, SERPINB2, DEFB103B, DEFB4A
40nitric oxide45 24 1111.1SERPINB2, MMP8, IL1B, IL1A
41retinoic acid45 2410.0DEFB4A, DEFB1, SERPINB2, MMP8, IL1B, IL1A
42rantes459.0DEFB4A, DEFB1, CXCL6, IL1B, IL1A
43vegf458.9SERPINB2, MMP8, CXCL6, IL1B, IL1A
44dexamethasone45 51 29 1111.7DEFB4A, DEFB103B, DEFB1, SERPINB2, IL1B, IL1A
45hbd2458.5IL1B, DEFB1, DEFB103B, DEFA3, DEFB4A
46calcium45 51 24 1111.4CXCL6, MMP8, SERPINB2, FCGR3B, DEFB103B, DEFB4A
47serine458.4IL1A, CXCL6, MMP8, SERPINB2, FCGR3B

GO Terms for genes affiliated with Periodontal Disease

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16Gene Ontology
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Cellular components related to Periodontal Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.1DEFB1, DEFA3, DEFB4A
2extracellular spaceGO:0056156.6DEFA3, CFHR1, SERPINB2, MMP8, CXCL6, IL17F
3extracellular regionGO:0055766.3IL1A, DEFB4A, DEFA3, DEFB1, FCGR3B, SERPINB2

Biological processes related to Periodontal Disease according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1fever generationGO:0016609.9IL1B, IL1A
2ectopic germ cell programmed cell deathGO:0352349.9IL1A, IL1B
3positive regulation of interleukin-2 biosynthetic processGO:0450869.8IL1A, IL1B
4positive regulation vascular endothelial growth factor productionGO:0105759.8IL1A, IL1B
5positive regulation of mitosisGO:0458409.7IL1B, IL1A
6positive regulation of cell divisionGO:0517819.7IL1A, IL1B
7negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.6IL1A, IL1B
8chemotaxisGO:0069359.4DEFB4A, DEFB1, CXCL6
9extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.4IL1A, IL1B
10inflammatory responseGO:0069548.9IL1A, IL1B, IL17F, CXCL6
11immune responseGO:0069558.5IL1A, IL1B, CXCL6, FCGR3B, DEFB1, DEFB4A

Molecular functions related to Periodontal Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:0051499.4IL1A, IL1B
2cytokine activityGO:0051259.3IL1A, IL1B, IL17F

Products for genes affiliated with Periodontal Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Periodontal Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet