MCID: PRD007
MIFTS: 42

Periodontal Disease

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Periodontal Disease

MalaCards integrated aliases for Periodontal Disease:

Name: Periodontal Disease 12 14
Periodontal Diseases 52 42 69
Disease of Supporting Structures of Teeth, Nos 12
Periodontium Disorder 12
Gingival Diseases 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3388
ICD10 33 K05.6
MeSH 42 D010510
NCIt 47 C63743
UMLS 69 C0031090

Summaries for Periodontal Disease

MalaCards based summary : Periodontal Disease, also known as periodontal diseases, is related to gingivitis and periodontosis, and has symptoms including halitosis, snoring and tenderness of gums. An important gene associated with Periodontal Disease is IL1B (Interleukin 1 Beta). The drugs sodium fluoride and Triclosan have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and testes.

Wikipedia : 72 Periodontitis, also known as gum disease and pyorrhea, is a set of inflammatory diseases affecting the... more...

Related Diseases for Periodontal Disease

Graphical network of the top 20 diseases related to Periodontal Disease:



Diseases related to Periodontal Disease

Symptoms & Phenotypes for Periodontal Disease

UMLS symptoms related to Periodontal Disease:


halitosis, snoring, tenderness of gums, oral manifestations

Drugs & Therapeutics for Periodontal Disease

Drugs for Periodontal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 435)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 sodium fluoride Approved Phase 4,Phase 3,Phase 1,Phase 2 7681-49-4
2
Triclosan Approved Phase 4,Phase 3,Phase 1,Phase 2 3380-34-5 5564
3
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1 443-48-1 4173
4
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 564-25-0 54671203
5
Levonorgestrel Approved, Investigational Phase 4 797-63-7, 17489-40-6 13109
6
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3 26787-78-0 33613 2171
7
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-43-4 5816
8 Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
9
Chlorhexidine Approved, Vet_approved Phase 4,Phase 2,Phase 3 55-56-1 9552079 2713
10
Hexetidine Approved Phase 4 141-94-6
11
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2 22916-47-8 4189
12
Zinc Approved Phase 4,Phase 2,Phase 3 7440-66-6 32051 23994
13
Azithromycin Approved Phase 4,Phase 2 83905-01-5 55185 53477736 447043
14
Ciprofloxacin Approved, Investigational Phase 4,Phase 1 85721-33-1 2764
15
Ethanol Approved Phase 4,Phase 3,Phase 2 64-17-5 702
16
Acetaminophen Approved Phase 4,Phase 2,Phase 3 103-90-2 1983
17
Menthol Approved Phase 4,Phase 3,Early Phase 1 2216-51-5 16666
18
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 137-58-6 3676
19
Prilocaine Approved Phase 4 721-50-6 4906
20
Alginic acid Approved, Experimental Phase 4 9005-32-7
21
Minocycline Approved, Investigational Phase 4,Phase 3,Phase 1 10118-90-8 5281021
22
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
23
Methyl salicylate Approved, Vet_approved Phase 4 119-36-8 4133
24
Thymol Approved Phase 4 89-83-8 6989
25
Alendronate Approved Phase 4,Phase 2,Phase 3 121268-17-5, 66376-36-1 2088
26
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
27
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
28
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
29
Norgestimate Approved Phase 4 35189-28-7 6540478
30
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
31
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 1,Phase 2 9004-61-9 53477741 24759
32
Clarithromycin Approved Phase 4,Phase 2,Phase 3 81103-11-9 84029
33
Montelukast Approved Phase 4 158966-92-8 5281040
34 Cetylpyridinium Approved Phase 4,Phase 2,Phase 3,Phase 1 7773-52-6
35
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
36
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
37
Ibuprofen Approved Phase 4,Phase 2,Phase 3 15687-27-1 3672
38
Zoledronic acid Approved Phase 4 118072-93-8 68740
39
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-78-2 2244
40
Coal tar Approved Phase 4,Phase 3 8007-45-2
41
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
42
Methyltestosterone Approved Phase 4 58-18-4 6010
43
Testosterone Approved, Investigational Phase 4 58-22-0 6013
44
Hydrogen peroxide Approved, Vet_approved Phase 4 7722-84-1 784
45
Lycopene Approved, Nutraceutical Phase 4,Phase 1,Phase 2 502-65-8 446925
46
Vitamin C Approved, Nutraceutical Phase 4,Phase 3,Phase 2 50-81-7 5785 54670067
47
Lactitol Investigational Phase 4 585-86-4 3871
48
Imidacloprid Vet_approved Phase 4 105827-78-9 86418
49
Silicon Investigational Phase 4,Phase 1,Phase 2 7440-21-3 4082203
50 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 1056)

id Name Status NCT ID Phase Drugs
1 Clinical Investigation of the Effects of Colgate Total Toothpaste as Compared to a Matching Placebo on Periodontal Disease and Systemic Inflammatory Markers Unknown status NCT02670135 Phase 4 Triclosan Containing Toothpaste;Triclosan Free Toothpaste
2 The Treatment of Periodontal Diseases Unknown status NCT01318928 Phase 4 Metronidazol
3 Norplant and Irregular Bleeding/Spotting Unknown status NCT00064766 Phase 4 doxycycline
4 Effect of Actonel on Periodontal Health of Postmenopausal Women Unknown status NCT00594334 Phase 4 Risedronate
5 Role of Stress Reduction Protocol on Outcome of Periodontal Therapy Unknown status NCT02487862 Phase 4
6 Bone Quality and Quantity Following Guided Bone Regeneration Prior to Dental Implant Placement Unknown status NCT01603693 Phase 4
7 Periodontal Therapy in Coronary Artery Patients Unknown status NCT01609725 Phase 4
8 Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care Unknown status NCT01195493 Phase 4
9 Metronidazole and Amoxicillin for the Treatment of Type 2 Diabetic Subjects With Periodontitis Unknown status NCT02135952 Phase 4 MTZ+AMX
10 SRP in Combination With PERIOWAVE in Comparison to SRP Alone in Chronic Periodontitis Unknown status NCT00296881 Phase 4
11 Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic Therapy Unknown status NCT01532674 Phase 4
12 Study of Scaling and Root Planing With PerioWave Versus Scaling and Root Planing Alone in Chronic Periodontitis Unknown status NCT00297531 Phase 4
13 Methodology Antiseptic Application, Influence on Oral Biofilm. Unknown status NCT02267239 Phase 4 essential oils, immersion;Chlorhexidine, immersion;essential oils, mouthwash;chlorhexidine, mouthwash
14 Evaluation of a Lateral Window Technique Augmentation for Maxillary Sinus Using Ultrasound Activated Pins Unknown status NCT02449707 Phase 4
15 Laser De-epithelialization for Epithelial Exclusion in Root Coverage Procedure: a Clinical Study Unknown status NCT02626117 Phase 4
16 Connective Tissue Graft Versus Mucograft Collagen Matrix for Coverage of Multiple Gingival Recession Defects Unknown status NCT01440426 Phase 4
17 Platelet Rich Fibrin in the Treatment of Palatal Wounds Unknown status NCT02438046 Phase 4
18 Anticaries Effect of Probiotic Lactobacillus Brevis CD2 (Lb CD2). Unknown status NCT01778699 Phase 4
19 Adhesion of Connective Tissue Around Laser-treated Abutments for Dental Implants - Clinical Trial in Humans Unknown status NCT01954485 Phase 4
20 Evaluation of Platelet Rich Fibrin on Reduction of Periodontal Problems After Surgical Removal of Mandibular Third Molar Unknown status NCT01583491 Phase 4
21 Relationship of Periodontal Disease Treatment and Type 2 Diabetes Mellitus in the Gullah Population Completed NCT01798225 Phase 4 Placebo;Doxycycline
22 Periodontal Treatment Response in Type II Diabetic Patients Completed NCT01881074 Phase 4 Triclosan containing toothpaste;Non-triclosan containing toothpaste
23 Conventional or Minimally Invasive Surgical Technique for the Treatment of Furcation Defects Using Enamel Matrix Derivative and Anorganic Bovine Bone - a Randomized Controlled Clinical Trial. Completed NCT02102360 Phase 4
24 Pediatric Study to Access Pharmacokinetics and Safety of Oraqix Gel Completed NCT01591616 Phase 4 lidocaine and prilocaine
25 EMD and/or Bone Substitute for the Treatment of Class II Furcations Completed NCT02474498 Phase 4 EMD
26 Efficacy of Two Oral Hygiene Regimens in the Reduction of Dentin Hypersensitivity After Periodontal Treatment Completed NCT02461030 Phase 4 In-office and at home Colgate sensitive pro-relief - CSPR;In-office Villevie® prophy paste + Colgate Toothpaste
27 Locally Delivered Doxycycline Adjunct to Nonsurgical Periodontal Therapy. Completed NCT02487186 Phase 4 Doxicicline
28 Study on Regenerative Treatment of Intra-bony Defects Completed NCT00757159 Phase 4
29 Long-term Safety of Minocycline in Patients With Gum Disease Completed NCT00668746 Phase 4 Minocycline HCl microspheres
30 Interaction Between Chlorhexidine and Fluoride Completed NCT02935322 Phase 4 0.12 % chlorhexidine + 0.2 % NaF mouthrinse;0.2 % NaF mouthrinse;0.12% chlorhexidine
31 A Clinical Trial to Test the Effect of Experimental Mouth Rinse on Gum Disease Completed NCT02065414 Phase 4
32 A Clinical Trial to Study the Effect of Lycopene in Patients With Gum Disease and type2 Diabetes Mellitus Completed NCT02263352 Phase 4 Lycored soft gels Jagsonpal Pharma, Systemic 8mgms/day
33 Prospective Double-Blind Randomized Controlled Clinical Trial in the Gingivitis Prevention With OPCs Completed NCT02515929 Phase 4
34 Photodynamic Therapy During Supportive Periodontal Therapy Completed NCT02666573 Phase 4
35 Host Modulatory Effects of β-glucan on Localized Aggressive Periodontitis Completed NCT02402296 Phase 4 β-1,3/1,6-D-glucan
36 Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing Completed NCT02197260 Phase 4 3/d 500 mg metronidazole plus 375 mg amoxicillin for 7 days
37 Impact of Periodontal Treatment on Serum Levels of Hepcidin and Hemoglobin Completed NCT02641210 Phase 4 Albendazole
38 Effect of Arthrospira Platensis (Spirulina) as an Adjunct to Scaling and Root Planing on Salivary Antioxidant Levels in Chronic Periodontitis Subjects Completed NCT02886676 Phase 4 Spirulina capsules
39 Effects of the Variation in the Time of Systemic Administration of Metronidazole and Amoxicillin Associated to the Non-surgical Therapy of Chronic Periodontitis. Completed NCT01211223 Phase 4 Administration of Metronidazole plus Amoxicillin
40 Effect of Scaling and Root Planing Along With Topical Application of Commercially Available Curcuma Longa Gel on Superoxide Dismutase and Malondialdehyde Levels in Saliva of Chronic Periodontitis Patients Completed NCT02442453 Phase 4 Topical application of curenext gel;Placebo
41 Mechanical-chemical Gingival Therapy in Diabetics and/or Obese Completed NCT02123563 Phase 4
42 Sodium Alendronate in Non Surgical Periodontal Therapy Completed NCT02470611 Phase 4 Sodium alendronate
43 Bacteremia in Periodontal Patients Completed NCT02215473 Phase 4 Chlorhexidine gluconate mouth rinse
44 Treatment of Periodontitis by Conventional 4 Weekly Sections or Within 24 Hours Completed NCT02215460 Phase 4 FMS chlorhexidine rinse;FMS placebo rinse;FMS azithromycin tablets;FMS placebo tablets;QS azithromycin tablets;QS placebo tablets;QS chlorhexidine rinse;QS placebo rinse
45 DFDBA and Xenograft (Cerabone)TM With Decortication in Intrabony Defects Completed NCT02949557 Phase 4
46 MTZ Plus AMX in the Treatment of Smokers and Non-smokers Completed NCT01837199 Phase 4 Metronidazole plus Amoxicillin
47 Regenerative Surgical Treatment of Peri-implantitis Completed NCT02500654 Phase 4
48 Gingival Recession Coverage With and Without Emdogain Completed NCT02230787 Phase 4
49 Estimation of Interleukin-21 Levels in Gingival Crevicular Fluid in Patients With Periodontal Health and Disease Following Non-surgical Periodontal Therapy: A Clinico-biochemical Study Completed NCT02861937 Phase 4
50 Treatment of Chronic Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02734784 Phase 4

Search NIH Clinical Center for Periodontal Disease

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: periodontal diseases

Genetic Tests for Periodontal Disease

Anatomical Context for Periodontal Disease

MalaCards organs/tissues related to Periodontal Disease:

39
Bone, Kidney, Testes, Heart, Neutrophil, Endothelial, Ovary

Publications for Periodontal Disease

Articles related to Periodontal Disease:

(show top 50) (show all 1011)
id Title Authors Year
1
Combined antioxidant effects of Neem extract, bacteria, red blood cells and Lysozyme: possible relation to periodontal disease. ( 28797303 )
2017
2
Association between periodontal disease and mortality in people with CKD: a meta-analysis of cohort studies. ( 28814274 )
2017
3
Association Between Asthma and Periodontal Disease: A Systematic Review and Meta-Analysis. ( 28871892 )
2017
4
Periodontal disease and risk of non-Hodgkin lymphoma in the Health Professionals Follow-Up Study. ( 27861844 )
2017
5
Genetic susceptibility and periodontal disease: a retrospective study on a large italian sample. ( 28757932 )
2017
6
Qualitative and Quantitative Proteome Analysis of Oral Fluids in Health and Periodontal Disease by Mass Spectrometry. ( 27924587 )
2017
7
Periodontal Disease and Incident Cancer Risk among Postmenopausal Women: Results from the Women's Health Initiative Observational Cohort. ( 28765338 )
2017
8
Prevalence and risk indicators of peri-implantitis in Korean patients with a history of periodontal disease: a cross-sectional study. ( 28861288 )
2017
9
Treatment of experimental periodontal disease by laser therapy in simvastatin-modified rats. ( 28877277 )
2017
10
Association between interleukin-8 levels and chronic periodontal disease: A PRISMA-compliant systematic review and meta-analysis. ( 28562542 )
2017
11
Receiver Operating Characteristic (ROC) Curve-based Prediction Model for Periodontal Disease Updated With the Calibrated Community Periodontal Index. ( 28753099 )
2017
12
Matrix metalloproteinase-8 levels in periodontal disease patients: A systematic review. ( 28898418 )
2017
13
Association of periodontal disease with glycemic control in patients with type 2 diabetes in Indian population. ( 28050765 )
2017
14
Thermoreversible in situ gel for subgingival delivery of simvastatin for treatment of periodontal disease. ( 28929053 )
2017
15
Socioeconomic factors and severity of periodontal disease in adults (35-44 years). A cross sectional study. ( 28936289 )
2017
16
Tooth loss, periodontal disease, and dental caries may be associated with decreased oral health-related quality of life, but there is no evidence about the magnitude of this association. ( 28821339 )
2017
17
Risk factors of periodontal disease in maintenance hemodialysis patients. ( 28858105 )
2017
18
Viruses: Bystanders of periodontal disease. ( 27899307 )
2017
19
Correlation of ABO Blood Group Phenotype and Rhesus Factor with Periodontal Disease: An Observational Study. ( 28839412 )
2017
20
Serum lipid levels in patients with periodontal disease. A meta-analysis and meta-regression. ( 28782128 )
2017
21
Immediate implant placement and complete mouth rehabilitation with CAD-CAM titanium frameworks and cemented crowns for a patient with severe periodontal disease: A clinical report. ( 28781070 )
2017
22
Long-term Hyperglycemia Naturally Induces Dental Caries But Not Periodontal Disease in Type-1 and Type-2 Diabetic Rodents. ( 28793985 )
2017
23
Association between Periodontal disease and Prostate cancer: Results of a 12-year Longitudinal Cohort Study in South Korea. ( 28928887 )
2017
24
Inhibition of 5-Lipoxygenase (5-Lo) Attenuates Inflammation and Bone Resorption in Lipopolysaccharide (Lps)-Induced Periodontal Disease. ( 28871891 )
2017
25
Salivary Alkaline Phosphatase as a Noninvasive Marker for Periodontal Disease in Children with Uncontrolled Type 1 Diabetes Mellitus. ( 28052205 )
2017
26
The relationship between periodontal disease, tooth loss and decreased skeletal bone mineral density in ageing women. ( 28812320 )
2017
27
Metabolic syndrome as a risk indicator for periodontal disease and tooth loss. ( 27604232 )
2016
28
Study of the participation of MMP-7, EMMPRIN and cyclophilin A in the pathogenesis of periodontal disease. ( 27597537 )
2016
29
Genome-wide association study of biologically informed periodontal complex traits offers novel insights into the genetic basis of periodontal disease. ( 26962152 )
2016
30
Formulation and evaluation of hydrogel containing dry extract of Tormentillae rhizoma designed for periodontal disease. ( 27976217 )
2016
31
Correlation of interleukin-6-174 GC and interleukin-6-572 GC gene polymorphisms with periodontal disease in an Iranian population. ( 27605994 )
2016
32
Topical HPMC/S-Nitrosoglutathione Solution Decreases Inflammation and Bone Resorption in Experimental Periodontal Disease in Rats. ( 27116554 )
2016
33
Follicular dendritic cell-secreted protein may enhance osteoclastogenesis in periodontal disease. ( 26577469 )
2016
34
Trends in Susceptibility to Aggressive Periodontal Disease. ( 28008419 )
2016
35
Regulator of Calcineurin 1 in Periodontal Disease. ( 27403036 )
2016
36
Number of teeth predict depressive symptoms in a longitudinal study on patients with periodontal disease. ( 27663105 )
2016
37
Periodontal Disease and Breast Cancer-Response. ( 27197142 )
2016
38
A New Multi-Ingredient Recipe for the Treatment of Localized Advanced Periodontal Disease following the Surgical Removal of Impacted Wisdom Teeth. ( 27217960 )
2016
39
Lack of association between the TNF-I+-1031genotypes and generalized aggressive periodontitis disease. ( 27755954 )
2016
40
The effects of P. gingivalis and E. coli LPS on the expression of proinflammatory mediators in human mast cells and their relevance to periodontal disease. ( 27655482 )
2016
41
A Pilot Study of Active Enzyme Levels in Gingival Crevicular Fluid of Patients with Chronic Periodontal Disease. ( 27106161 )
2016
42
Further evidence for periodontal disease as a risk indicator for adverse pregnancy outcomes. ( 27988930 )
2016
43
Periodontal diseases and risk of oral cancer in Southern India: Results from the HeNCe Life study. ( 27215979 )
2016
44
The Kidney and Periodontal Disease (KAPD) study: A pilot randomized controlled trial testing the effect of non-surgical periodontal therapy on chronic kidney disease. ( 28011387 )
2016
45
Clinical and postextraction evaluation of periodontal disease indicators. ( 27143828 )
2016
46
Identification of biomarkers for periodontal disease using the immunoproteomics approach. ( 27635317 )
2016
47
Viral serological and molecular data on possible involvement of herpes viruses in periodontal disease. ( 27916250 )
2016
48
Periodontal Disease and Adverse Pregnancy Outcomes: A Prospective Study in a Low-Risk Population. ( 27208603 )
2016
49
Vitamin D Status and Prevalent and Incident Tooth Loss in Postmenopausal Women: The Buffalo Osteoporosis and Periodontal Disease (OsteoPerio) Study. ( 27086615 )
2016
50
A retrospective study on periodontal disease progression in private practice. ( 27883212 )
2016

Variations for Periodontal Disease

Expression for Periodontal Disease

Search GEO for disease gene expression data for Periodontal Disease.

Pathways for Periodontal Disease

GO Terms for Periodontal Disease

Sources for Periodontal Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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