MCID: PRD008
MIFTS: 63

Periodontitis malady

Categories: Gastrointestinal diseases, Oral diseases, Genetic diseases, Blood diseases, Rare diseases

Aliases & Classifications for Periodontitis

Aliases & Descriptions for Periodontitis:

Name: Periodontitis 12 29 42 14 69
Chronic Pericementitis 12
Chronic Periodontitis 69

Characteristics:

HPO:

32
periodontitis:
Inheritance autosomal recessive inheritance
Onset and clinical course onset


Classifications:



External Ids:

Disease Ontology 12 DOID:824
ICD10 33 K05.3
MeSH 42 D010518
NCIt 47 C34918
UMLS 69 C0031099

Summaries for Periodontitis

MalaCards based summary : Periodontitis, also known as chronic pericementitis, is related to periodontosis and stomatitis, and has symptoms including halitosis, snoring and tenderness of gums. An important gene associated with Periodontitis is IL1B (Interleukin 1 Beta), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Ethanol and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and endothelial, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 71 Periodontitis, also known as gum disease and pyorrhea, is a set of inflammatory diseases affecting the... more...

Related Diseases for Periodontitis

Diseases in the Periodontitis family:

Periodontitis 1, Juvenile Susceptibility to Localized Juvenile Periodontitis

Diseases related to Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 531)
id Related Disease Score Top Affiliating Genes
1 periodontosis 33.0 IL1A IL1RN TNF
2 stomatitis 30.0 CXCL8 IL1RN IL6
3 amelogenesis imperfecta 30.0 CXCL8 IL10 IL6 TNF
4 myocardial infarction 29.9 IL10 IL1B IL6 MMP9 TIMP1 TNF
5 tinea capitis 29.8 IL1B IL6 TNF
6 tuberculosis 29.7 IL10 IL1B IL6 TNF
7 rheumatoid arthritis 29.7 CXCL8 IL10 IL1A IL1B IL1RN IL6
8 osteonecrosis 29.6 CXCL8 IL1B IL6 MMP1 TIMP1 TNF
9 hepatitis 29.5 IL10 IL6 TNF
10 peripheral vascular disease 29.5 ELANE MMP1 MMP8
11 glucose intolerance 29.5 CXCL8 TIMP1 TNF
12 meningitis 29.5 CXCL8 IL1A IL6 TNF
13 peripheral artery disease 29.4 IL10 TLR2 TNF
14 fasciitis 29.3 CXCL8 ELANE MMP8 TLR2 TNF
15 histiocytosis 28.2 CTSC CXCL8 DEFB1 ELANE IL1A IL1B
16 aggressive periodontitis 12.4
17 periodontal disease 12.4
18 periapical periodontitis 12.3
19 periodontitis 1, juvenile 12.2
20 chronic apical periodontitis 12.1
21 acute apical periodontitis 12.1
22 ehlers-danlos syndrome, periodontal type 2 12.1
23 periodontal ehlers-danlos syndrome 11.9
24 hypotrichosis-osteolysis-periodontitis-palmoplantar keratoderma syndrome 11.8
25 suppurative periapical periodontitis 11.8
26 periodontitis, aggressive, 2 11.7
27 ehlers-danlos syndrome, type viii 11.7
28 ehlers-danlos syndrome, periodontal type 1 11.7
29 susceptibility to localized juvenile periodontitis 11.7
30 papillon-lefevre syndrome 11.6
31 gingivitis 11.5
32 necrotizing ulcerative gingivitis 11.3
33 acute pericementitis 11.3
34 haim-munk syndrome 11.0
35 hajdu-cheney syndrome 11.0
36 ligneous conjunctivitis 11.0
37 dental abscess 10.9
38 singleton-merten syndrome 1 10.7
39 aplasia of lacrimal and salivary glands 10.7
40 amelogenesis imperfecta, type iii 10.7
41 tooth ankylosis 10.7
42 intussusception 10.4 IL1B TNF
43 toxic optic neuropathy 10.4 IL1A IL1B MMP9
44 bipolar i disorder 10.4 IL1B IL6 TNF
45 swine influenza 10.4 IL1A IL6 TNF
46 cerebellar disease 10.4 IL1A IL1B TNF
47 human immunodeficiency virus infectious disease 10.4 IL1B IL6 TNF
48 oculomotor nerve paralysis 10.4 CXCL8 IL1B IL6
49 common peroneal nerve lesion 10.4 CXCL8 IL1B IL6
50 measles 10.4 IL1B IL6 TNF

Comorbidity relations with Periodontitis via Phenotypic Disease Network (PDN):


Acute Cystitis Dental Caries
Heart Disease

Graphical network of the top 20 diseases related to Periodontitis:



Diseases related to Periodontitis

Symptoms & Phenotypes for Periodontitis

Human phenotypes related to Periodontitis:

32
id Description HPO Frequency HPO Source Accession
1 periodontitis 32 HP:0000704

UMLS symptoms related to Periodontitis:


halitosis, snoring, tenderness of gums, leukorrhea, purulent discharge

MGI Mouse Phenotypes related to Periodontitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.28 TIMP1 TLR2 TLR4 TNF TNFRSF11B TNFSF11
2 homeostasis/metabolism MP:0005376 10.28 TLR2 TLR4 TNF TNFSF11 IL10 IL1A
3 immune system MP:0005387 10.27 CTSC ELANE IL10 IL1A IL1B IL1RN
4 cardiovascular system MP:0005385 10.2 IL10 IL1A IL1B IL1RN IL6 MMP9
5 integument MP:0010771 10.06 CTSC IL10 IL1A IL1B IL1RN IL6
6 neoplasm MP:0002006 9.97 TLR2 TLR4 TNF TNFSF11 ELANE IL10
7 limbs/digits/tail MP:0005371 9.8 IL10 MMP9 TIMP1 TLR4 TNF TNFRSF11B
8 respiratory system MP:0005388 9.56 TIMP1 TLR2 TLR4 TNF TNFSF11 IL10
9 skeleton MP:0005390 9.36 IL10 IL1B IL1RN IL6 MMP9 TIMP1

Drugs & Therapeutics for Periodontitis

Drugs for Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 335)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4,Phase 3 64-17-5 702
2
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 1 51-43-4 5816
3
Ciprofloxacin Approved, Investigational Phase 4,Phase 1 85721-33-1 2764
4 sodium fluoride Approved Phase 4,Phase 3 7681-49-4
5
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2 22916-47-8 4189
6
Azithromycin Approved Phase 4,Phase 2 83905-01-5 55185 53477736 447043
7
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 26787-78-0 33613 2171
8
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1 443-48-1 4173
9
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 55-56-1 9552079 2713
10
Menthol Approved Phase 4,Early Phase 1 2216-51-5 16666
11
Hexetidine Approved Phase 4 141-94-6
12
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-78-2 2244
13
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757 53477783
14
Montelukast Approved Phase 4 158966-92-8 5281040
15
Ibuprofen Approved Phase 4,Phase 2,Phase 3 15687-27-1 3672
16
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 1,Phase 2 9004-61-9 53477741 24759
17
Alendronate Approved Phase 4,Phase 2,Phase 3 121268-17-5, 66376-36-1 2088
18
Zoledronic acid Approved Phase 4 118072-93-8 68740
19
Norgestimate Approved Phase 4 35189-28-7 6540478
20
Minocycline Approved, Investigational Phase 4,Phase 3,Phase 1 10118-90-8 5281021
21
Clarithromycin Approved Phase 4,Phase 2,Phase 3 81103-11-9 84029
22
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 564-25-0 54671203
23
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
24
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
25
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
26
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
27
Triclosan Approved Phase 4,Phase 3 3380-34-5 5564
28
Povidone-iodine Approved Phase 4 25655-41-8
29
Coal tar Approved Phase 4 8007-45-2
30
Methylene blue Investigational Phase 4,Phase 2 61-73-4
31 Fluorides Phase 4,Phase 3
32 Chlorhexidine gluconate Phase 4,Phase 3,Phase 2,Phase 1
33
Lactitol Phase 4 585-86-4 3871
34 Risedronate Sodium Phase 4 115436-72-1
35 calcium channel blockers Phase 4
36 Chelating Agents Phase 4
37 Coagulants Phase 4,Phase 2,Phase 3,Phase 1
38 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 1
39 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
40 Tolonium Chloride Phase 4,Phase 2,Phase 3
41 Hemostatics Phase 4,Phase 2,Phase 3,Phase 1
42 Topoisomerase Inhibitors Phase 4,Phase 1
43 Dermatologic Agents Phase 4,Phase 2,Phase 3
44 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
45 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
46 Disinfectants Phase 4,Phase 3,Phase 2,Phase 1
47 Epinephryl borate Phase 4,Phase 2,Phase 1
48 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1
49 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
50 Photosensitizing Agents Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 529)
id Name Status NCT ID Phase
1 Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care Unknown status NCT01195493 Phase 4
2 Study of Scaling and Root Planing With PerioWave Versus Scaling and Root Planing Alone in Chronic Periodontitis Unknown status NCT00297531 Phase 4
3 SRP in Combination With PERIOWAVE in Comparison to SRP Alone in Chronic Periodontitis Unknown status NCT00296881 Phase 4
4 Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic Therapy Unknown status NCT01532674 Phase 4
5 Metronidazole and Amoxicillin for the Treatment of Type 2 Diabetic Subjects With Periodontitis Unknown status NCT02135952 Phase 4
6 Evaluation of Photodynamic Treatment FOTOSAN® Efficacy in Periodontology Unknown status NCT02030470 Phase 4
7 Methodology Antiseptic Application, Influence on Oral Biofilm. Unknown status NCT02267239 Phase 4
8 Effect of Actonel on Periodontal Health of Postmenopausal Women Unknown status NCT00594334 Phase 4
9 Periodontal Therapy in Coronary Artery Patients Unknown status NCT01609725 Phase 4
10 The Treatment of Periodontal Diseases Unknown status NCT01318928 Phase 4
11 Omega-3 Fatty Acids in Chronic Periodontitis. Completed NCT01997853 Phase 4
12 Comparison of Moxifloxacin With Ciprofloxacin/Metronidazole on Patients With Chronic Periodontitis Completed NCT00805558 Phase 4
13 Role of Leukotriene Receptor Antagonists in Treatment of Chronic Periodontitis Completed NCT02014532 Phase 4
14 The Response of Pathogens to the Respective or Combined Treatment of SRP and Local Minocycline in Chronic Periodontitis Completed NCT02355977 Phase 4
15 Treatment of Chronic Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02734784 Phase 4
16 Adjunctive Photodynamic Therapy in Treatment of Chronic Periodontitis Completed NCT01034501 Phase 4
17 Effect of Scaling and Root Planing Along With Topical Application of Commercially Available Curcuma Longa Gel on Superoxide Dismutase and Malondialdehyde Levels in Saliva of Chronic Periodontitis Patients Completed NCT02442453 Phase 4
18 Role of Herbal Immunomodulators in the Treatment of Chronic Periodontitis Completed NCT01997814 Phase 4
19 Locally Delivered Aloe Vera Gel in the Treatment of Chronic Periodontitis Patients With Diabetes Mellitus Completed NCT02437747 Phase 4
20 Effects of the Variation in the Time of Systemic Administration of Metronidazole and Amoxicillin Associated to the Non-surgical Therapy of Chronic Periodontitis. Completed NCT01211223 Phase 4
21 Propolis Improves Glycemic Control in Subjects With Type 2 Diabetes and Chronic Periodontitis Completed NCT02794506 Phase 4
22 "Effect of Scaling and Root Planing on Liver Function Test (Alanine Aminotransferase and Aspartate Aminotransferase) in Systemically Healthy - Chronic Periodontitis Subjects: a Clinical Trial." Completed NCT02583841 Phase 4
23 Study of Scaling and Root Planing (SRP) With PerioWave vs. SRP Alone in Chronic Periodontitis Completed NCT00297518 Phase 4
24 MTZ Plus AMX in the Treatment of Smokers and Non-smokers Completed NCT01837199 Phase 4
25 Effect of Arthrospira Platensis (Spirulina) as an Adjunct to Scaling and Root Planing on Salivary Antioxidant Levels in Chronic Periodontitis Subjects Completed NCT02886676 Phase 4
26 Impact of Periodontal Treatment on Serum Levels of Hepcidin and Hemoglobin Completed NCT02641210 Phase 4
27 Moxifloxacin in Situ Gel to Treat Periodontal Pocket. Completed NCT02016157 Phase 4
28 Effect on Teeth and Gum Cleaning in Patients With Gum and Kidney Disease Completed NCT02901743 Phase 4
29 Long-term Safety of Minocycline in Patients With Gum Disease Completed NCT00668746 Phase 4
30 Changes of GCF Levels of RANKL and Osteoprotegerin in Postmenopausal Osteoporosis Completed NCT02808988 Phase 4
31 Treatment of Intrabony Periodontal Defects With Enamel Matrix Derivatives and Autogenous Bone Graft Completed NCT02218515 Phase 4
32 Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients Completed NCT01647282 Phase 4
33 A Clinical Trial to Study the Effect of Lycopene in Patients With Gum Disease and type2 Diabetes Mellitus Completed NCT02263352 Phase 4
34 Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing Completed NCT02197260 Phase 4
35 Atorvastatin as an Adjunct to DFDBA in Intrabony Defects Completed NCT03009097 Phase 4
36 Estimation of Interleukin-21 Levels in Gingival Crevicular Fluid in Patients With Periodontal Health and Disease Following Non-surgical Periodontal Therapy: A Clinico-biochemical Study Completed NCT02861937 Phase 4
37 Full-mouth and Partial-mouth Scaling and Root Planing in Type 2 Diabetic Subjects Completed NCT02062047 Phase 4
38 Photodynamic Therapy During Supportive Periodontal Therapy Completed NCT02666573 Phase 4
39 Sodium Alendronate in Non Surgical Periodontal Therapy Completed NCT02470611 Phase 4
40 Locally Delivered Doxycycline Adjunct to Nonsurgical Periodontal Therapy. Completed NCT02487186 Phase 4
41 EFFECT OF SELECTIVE COX-2 INHIBITOR (ETORICOXIB) ALONG WITH SCALING AND ROOT PLANING (SRP) ON CLINICAL PARAMETERS AND SALIVARY LEVEL OF SUPEROXIDE DISMUTASE IN CHRONIC GENERALIZED PERIODONTITIS A DOUBLE-BLIND, PLACEBO-CONTROLLED, DOUBLE-MASKED RANDOMIZED Completed NCT02149758 Phase 4
42 Host Modulatory Effects of β-glucan on Localized Aggressive Periodontitis Completed NCT02402296 Phase 4
43 Antiplaque Effect of Essential Oils and 0.2% Chlorhexidine on an in Situ Model of Oral Biofilm Growth. Completed NCT02124655 Phase 4
44 Coronally Advanced Flap and PRF With or Without Demineralized Freeze-dried Bone Allograft in Gingival Recession Completed NCT02835430 Phase 4
45 Study to Evaluate Clinical Efficacy and Safety of Bio Mineral Toothpaste in Patients With Mild Periodontitis Completed NCT01548469 Phase 4
46 Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis Completed NCT02125812 Phase 4
47 Adjunctive Antimicrobial Therapy of Periodontitis: Long-Term Effects on Disease Progression and Oral Microbiological Colonization Completed NCT00707369 Phase 4
48 Evaluation of Efficacy of Full-mouth Disinfection in Generalized Aggressive Periodontitis Patients Completed NCT02466646 Phase 4
49 Treatment of Aggressive Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02049008 Phase 4
50 Treatment of Periodontitis by Conventional 4 Weekly Sections or Within 24 Hours Completed NCT02215460 Phase 4

Search NIH Clinical Center for Periodontitis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: periodontitis

Genetic Tests for Periodontitis

Genetic tests related to Periodontitis:

id Genetic test Affiliating Genes
1 Periodontitis 29

Anatomical Context for Periodontitis

MalaCards organs/tissues related to Periodontitis:

39
Bone, Neutrophil, Endothelial, Heart, T Cells, Monocytes, Kidney

Publications for Periodontitis

Articles related to Periodontitis:

(show top 50) (show all 4009)
id Title Authors Year
1
Association between the interleukin-1I^ C-511T polymorphism and periodontitis: a meta-analysis in the Chinese population. ( 28252166 )
2017
2
Clinical Relevance of Cytokines Gene Polymorphisms and Protein Levels in Gingival Cervical Fluid from Chronic Periodontitis Patients. ( 28341818 )
2017
3
Evaluation of Bacteriological Profile in the Apical Root Segment of the Patients with Primary Apical Periodontitis. ( 28050984 )
2017
4
Intra-abdominal abscesses by Lactococcus lactis ssp cremoris in an immunocompetent adult with severe periodontitis and pernicious anemia. ( 28050349 )
2017
5
Periostin is essential for periodontal ligament remodeling during orthodontic treatment. ( 28260019 )
2017
6
Meloxicam medication reduces orthodontically induced dental root resorption and tooth movement velocity: a combined in vivo and in vitro study of dental-periodontal cells and tissue. ( 28044198 )
2017
7
Effect of ancestry on interleukin-10 haplotypes in chronic periodontitis. ( 28410151 )
2017
8
Qualitative and Quantitative Proteome Analysis of Oral Fluids in Health and Periodontal Disease by Mass Spectrometry. ( 27924587 )
2017
9
IL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF, serum and clinic parameters. ( 28099578 )
2017
10
Treatment compliance in patients with aggressive periodontitis - a retrospective case-control study. ( 27899029 )
2017
11
Viruses: Bystanders of periodontal disease. ( 27899307 )
2017
12
Association of periodontal disease with glycemic control in patients with type 2 diabetes in Indian population. ( 28050765 )
2017
13
A Clinical Validation of Self-Reported Periodontitis Among Participants in the Black Women's Health Study. ( 28088874 )
2017
14
Periodontal disease and risk of non-Hodgkin lymphoma in the Health Professionals Follow-Up Study. ( 27861844 )
2017
15
Salivary Alkaline Phosphatase as a Noninvasive Marker for Periodontal Disease in Children with Uncontrolled Type 1 Diabetes Mellitus. ( 28052205 )
2017
16
Rheumatoid arthritis: New model linking periodontitis and RA. ( 28053334 )
2017
17
Insulin-like growth factor 1 (IGF1) affects proliferation and differentiation and wound healing processes in an inflammatory environment with p38 controlling early osteoblast differentiation in periodontal ligament cells. ( 27769028 )
2017
18
Salivary TNFI+ levels in groups of subjects with rheumatoid arthritis and chronic periodontitis. ( 28061876 )
2017
19
Association between periodontitis and arterial hypertension: A systematic review and meta-analysis. ( 27659888 )
2016
20
Association between Smoking and Periodontal Disease in Korean Adults: The Fifth Korea National Health and Nutrition Examination Survey (2010 and 2012). ( 27073611 )
2016
21
In Situ Anabolic Activity of Periodontal Pathogens Porphyromonas gingivalis and Filifactor alocis in Chronic Periodontitis. ( 27642101 )
2016
22
Formulation and evaluation of hydrogel containing dry extract of Tormentillae rhizoma designed for periodontal disease. ( 27976217 )
2016
23
Symptoms of depression and their relation to myocardial infarction and periodontitis. ( 28032516 )
2016
24
Treatment of a Periodontic-Endodontic Lesion in a Patient with Aggressive Periodontitis. ( 27418983 )
2016
25
Handling the Periodontal Disease in Community. ( 27114992 )
2016
26
Antimicrobial Susceptibility of Microorganisms Isolated from Periapical Periodontitis Lesions. ( 27665691 )
2016
27
Identification of biomarkers for periodontal disease using the immunoproteomics approach. ( 27635317 )
2016
28
Peri-implant and periodontal microbiome diversity in aggressive periodontitis patients: a pilot study. ( 27170047 )
2016
29
Number of teeth predict depressive symptoms in a longitudinal study on patients with periodontal disease. ( 27663105 )
2016
30
Nuclear Factor Erythroid 2-Related Factor 2 Down-Regulation in Oral Neutrophils Is Associated with Periodontal Oxidative Damage and Severe Chronic Periodontitis. ( 27070823 )
2016
31
Role of NOD2 and RIP2 in host-microbe interactions with Gram-negative bacteria: insights from the periodontal disease model. ( 27605548 )
2016
32
Width of Keratinized Mucosa at Implant Sites in Patients Treated for Generalized Aggressive Periodontitis: A Cohort Study. ( 27004285 )
2016
33
Platelet activation and platelet-leukocyte interaction in generalized aggressive periodontitis. ( 27334227 )
2016
34
In Vivo Inhibition of Porphyromonas Gingivalis Growth and Prevention of Periodontitis With Quorum-Sensing Inhibitors. ( 27177290 )
2016
35
Should implants be considered for patients with periodontal disease? ( 27932832 )
2016
36
Salivary and serum inflammatory mediators among pre-conception women with periodontal disease. ( 27978823 )
2016
37
Viral serological and molecular data on possible involvement of herpes viruses in periodontal disease. ( 27916250 )
2016
38
Alarming Skin Tatoo with Periodontal Link: Sturge Weber Syndrome. ( 27437380 )
2016
39
Association between IL-1I+ rs17561 and IL-1I^ rs1143634 polymorphisms and periodontitis: a meta-analysis. ( 26909953 )
2016
40
Periodontal disease detection in primary and mixed dentitions. ( 27613405 )
2016
41
Comparison of ozone gas and sodium hypochlorite/chlorhexidine two-visit disinfection protocols in treating apical periodontitis: a randomized controlled clinical trial. ( 27173580 )
2016
42
Relationship among Periodontal Disease, Insulin Resistance, Salivary Cortisol, and Stress Levels during Pregnancy. ( 27058372 )
2016
43
Gingival Crevicular Fluid and Saliva Stress Hormone Levels in Patients with Chronic and Aggressive Periodontitis. ( 27513682 )
2016
44
The Kidney and Periodontal Disease (KAPD) study: A pilot randomized controlled trial testing the effect of non-surgical periodontal therapy on chronic kidney disease. ( 28011387 )
2016
45
Cellular Profile and Expression of Immunologic Markers in Chronic Apical Periodontitis fromA HIV-infected Patients Undergoing HighlyA Active Antiretroviral Therapy. ( 27118467 )
2016
46
Comparative evaluation of management of gingival recession using subepithelial connective tissue graft and collagen membrane by periodontal microsurgical technique: A clinical study of 40 cases. ( 27143833 )
2016
47
Study of the participation of MMP-7, EMMPRIN and cyclophilin A in the pathogenesis of periodontal disease. ( 27597537 )
2016
48
Evaluation of melatonin levels in saliva in gingivitis and periodontitis cases: A pilot study. ( 27994421 )
2016
49
Editorial: Use of Saliva in Diagnosis of Periodontitis: Cumulative Use of Bacterial and Host-Derived Biomarkers. ( 28066728 )
2016
50
Periodontal Disease and Breast Cancer-Response. ( 27197140 )
2016

Variations for Periodontitis

Expression for Periodontitis

Search GEO for disease gene expression data for Periodontitis.

Pathways for Periodontitis

Pathways related to Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.89 CTSC CXCL8 DEFB1 DPP7 ELANE IL10
2
Show member pathways
13.74 CXCL8 IL10 IL1A IL1B IL6 TIMP1
3
Show member pathways
13.53 CXCL8 IL10 IL1A IL1B IL6 TIMP1
4
Show member pathways
13.45 CXCL8 IL10 IL1A IL1B IL1RN IL6
5
Show member pathways
13.39 CXCL8 IL10 IL1A IL1B IL6 TIMP1
6
Show member pathways
13.11 CXCL8 IL1A IL1B IL1RN IL6 TLR2
7
Show member pathways
13.04 CXCL8 IL10 IL1B IL6 MMP9 TLR2
8
Show member pathways
12.94 CXCL8 IL10 IL1A IL1B IL6 TNF
9
Show member pathways
12.93 CXCL8 IL1A IL1B IL6 TLR2 TLR4
10
Show member pathways
12.83 IL1A IL1B IL6 TIMP1 TLR2 TLR4
11
Show member pathways
12.8 ELANE MMP1 MMP8 MMP9 TIMP1
12
Show member pathways
12.75 IL1A IL1B TLR2 TLR4 TNF TNFRSF11B
13
Show member pathways
12.73 IL10 IL1A IL1B IL6 TLR2 TLR4
14 12.67 IL10 IL1B IL1RN TLR2 TNF TNFSF11
15
Show member pathways
12.66 IL10 IL1B IL6 TIMP1 TNF
16
Show member pathways
12.53 IL10 IL1A IL1B IL6 TNF
17
Show member pathways
12.47 CXCL8 IL1B IL6 MMP1 MMP9 TLR2
18
Show member pathways
12.41 CXCL8 IL1A IL6 TLR2 TLR4 TNF
19
Show member pathways
12.4 CXCL8 IL1A IL1B IL6 TLR4 TNF
20
Show member pathways
12.39 IL10 IL1A IL1B TLR2 TLR4 TNF
21 12.36 IL10 IL1A IL1B IL6 TLR2 TLR4
22 12.35 MMP9 TLR2 TLR4 TNF
23
Show member pathways
12.32 CXCL8 IL1B IL6 TLR2 TLR4 TNF
24 12.31 IL6 MMP1 MMP9 TLR2 TLR4 TNF
25 12.3 CXCL8 ELANE IL6 MMP9
26 12.3 CXCL8 IL10 IL1A IL1B IL1RN IL6
27
Show member pathways
12.29 CXCL8 IL10 IL1A IL1B IL6 TNF
28 12.19 IL1A IL1B TNF TNFRSF11B TNFSF11
29 12.17 IL1A IL1B MMP9 TNF
30 12.13 CXCL8 IL1A IL1B IL6 MMP9 TLR4
31
Show member pathways
12.12 IL1A IL1B TLR2 TLR4
32
Show member pathways
12.1 IL10 IL1B IL6 TLR2 TLR4 TNF
33 12.06 CXCL8 IL1A IL1B IL6 TNF
34
Show member pathways
12.06 ELANE MMP1 MMP8 MMP9 TIMP1 TNF
35 12.05 IL1B IL6 MMP9 TNF
36 12.04 CXCL8 IL1A IL1B IL6
37 12.03 CXCL8 IL1B TLR4 TNF TNFSF11
38
Show member pathways
12.02 IL1B IL6 TLR2 TLR4
39 11.99 IL1A IL1B IL6 TNF
40 11.98 CXCL8 IL10 IL1B IL6 TLR2 TLR4
41 11.97 CXCL8 IL1A IL1B IL6 TLR4
42 11.88 IL10 IL1B IL6 TNF
43 11.87 CXCL8 IL10 IL1A IL1B IL6 MMP1
44 11.85 IL10 IL6 TLR2 TLR4 TNF
45 11.84 CXCL8 IL6 MMP1
46 11.83 IL10 IL1B TNF
47 11.83 CXCL8 IL10 IL1A IL1B IL6 TLR4
48 11.8 CXCL8 IL1B IL6 MMP9 TIMP1 TNF
49 11.79 CXCL8 MMP1 MMP9
50 11.78 CXCL8 MMP1 MMP9 TIMP1

GO Terms for Periodontitis

Cellular components related to Periodontitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.83 CTSC CXCL8 DEFB1 ELANE IL10 IL1A
2 proteinaceous extracellular matrix GO:0005578 9.55 MMP1 MMP8 MMP9 TIMP1 TNFRSF11B
3 extracellular region GO:0005576 9.55 CTSC CXCL8 DEFB1 DPP7 ELANE IL10

Biological processes related to Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 67)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.99 IL1B TLR4 TNF TNFSF11
2 cytokine-mediated signaling pathway GO:0019221 9.98 IL1A IL1B IL6 TNFSF11
3 response to organic substance GO:0010033 9.93 CTSC IL10 TIMP1 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.93 CXCL8 IL10 IL6 TLR4 TNF
5 positive regulation of protein kinase B signaling GO:0051897 9.91 IL6 TNF TNFSF11
6 apoptotic signaling pathway GO:0097190 9.91 TLR4 TNF TNFRSF11B
7 response to glucocorticoid GO:0051384 9.91 IL10 IL1RN IL6 TNF
8 response to insulin GO:0032868 9.9 IL10 IL6 TLR2
9 collagen catabolic process GO:0030574 9.9 MMP1 MMP8 MMP9
10 positive regulation of smooth muscle cell proliferation GO:0048661 9.89 ELANE IL6 TNF
11 defense response to Gram-positive bacterium GO:0050830 9.89 DEFB1 IL6 TLR2 TNF
12 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.89 IL10 IL1B IL6 TNF TNFSF11
13 positive regulation of MAP kinase activity GO:0043406 9.88 ELANE TNF TNFSF11
14 defense response to Gram-negative bacterium GO:0050829 9.87 DEFB1 IL6 TLR4
15 positive regulation of JNK cascade GO:0046330 9.87 IL1B TLR4 TNF TNFSF11
16 positive regulation of interferon-gamma production GO:0032729 9.85 IL1B TLR4 TNF
17 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.85 IL1A IL1B TNF
18 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 IL1B IL6 TLR2 TLR4 TNF TNFSF11
19 response to bacterium GO:0009617 9.84 DEFB1 IL6 TLR4
20 positive regulation of nitric oxide biosynthetic process GO:0045429 9.83 IL1B IL6 TLR4 TNF
21 extracellular matrix disassembly GO:0022617 9.83 ELANE MMP1 MMP8 MMP9 TIMP1
22 positive regulation of cytokine secretion GO:0050715 9.82 IL10 IL1A TNF
23 negative regulation of interleukin-6 production GO:0032715 9.81 IL10 TLR4 TNF
24 response to lipopolysaccharide GO:0032496 9.8 ELANE IL10 IL1B IL6 TLR2 TLR4
25 lipopolysaccharide-mediated signaling pathway GO:0031663 9.78 IL1B TLR2 TLR4 TNF
26 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.77 IL10 MMP9 TNF
27 negative regulation of growth of symbiont in host GO:0044130 9.76 ELANE IL10 TNF
28 positive regulation of interleukin-8 production GO:0032757 9.76 IL1B TLR2 TLR4 TNF
29 I-kappaB phosphorylation GO:0007252 9.74 TLR2 TLR4
30 regulation of cytokine secretion GO:0050707 9.74 TLR2 TLR4
31 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.74 IL1A IL1B
32 positive regulation of chemokine biosynthetic process GO:0045080 9.73 IL1B TNF
33 negative regulation of lipid storage GO:0010888 9.73 IL6 TNF
34 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.73 IL10 IL1RN
35 response to molecule of bacterial origin GO:0002237 9.73 CXCL8 IL10 TLR2
36 cellular response to lipoteichoic acid GO:0071223 9.72 TLR2 TLR4
37 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.72 IL1A IL1B
38 endothelial cell apoptotic process GO:0072577 9.72 IL10 TNF
39 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.72 IL10 IL1B TNF
40 positive regulation of MHC class II biosynthetic process GO:0045348 9.71 IL10 TLR4
41 ectopic germ cell programmed cell death GO:0035234 9.71 IL1A IL1B
42 response to yeast GO:0001878 9.71 ELANE IL6
43 positive regulation of NF-kappaB import into nucleus GO:0042346 9.71 IL1B TLR2 TLR4 TNF
44 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.7 IL10 TIMP1
45 regulation of establishment of endothelial barrier GO:1903140 9.7 IL1B TNF
46 negative regulation of cytokine secretion involved in immune response GO:0002740 9.69 IL10 TNF
47 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.69 IL6 TNF
48 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.69 ELANE TLR4 TNF
49 positive regulation of fever generation GO:0031622 9.68 IL1B TNF
50 sequestering of triglyceride GO:0030730 9.68 IL1B TNF

Molecular functions related to Periodontitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.73 CTSC DPP7 ELANE MMP1 MMP8 MMP9
2 serine-type endopeptidase activity GO:0004252 9.55 CTSC ELANE MMP1 MMP8 MMP9
3 endopeptidase activity GO:0004175 9.54 ELANE MMP1 MMP9
4 lipopolysaccharide receptor activity GO:0001875 9.32 TLR2 TLR4
5 cytokine activity GO:0005125 9.32 CXCL8 IL10 IL1A IL1B IL1RN IL6
6 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN

Sources for Periodontitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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