MCID: PRD008
MIFTS: 59

Periodontitis malady

Genetic diseases (common), Gastrointestinal diseases categories

Aliases & Classifications for Periodontitis

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 22GTR, 60UMLS, 38NCIt, 55SNOMED-CT, 33MeSH, 25ICD10
See all sources

Periodontitis, Aliases & Descriptions:

Name: Periodontitis 9 11 60
Chronic Periodontitis 9 43 22 60
 
Chronic Pericementitis 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:824
NCIt38 C34918
MeSH33 D010518
ICD1025 K05.3

Summaries for Periodontitis

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Wikipedia:63 Periodontitis /?p?rio?d?n?ta?t?s/ or pyorrhea /?pa???ri?/ is a set of inflammatory diseases affecting... more...

MalaCards based summary: Periodontitis, also known as chronic periodontitis, is related to aggressive periodontitis and periodontal disease, and has symptoms including autosomal recessive inheritance, periodontitis and onset. An important gene associated with Periodontitis is CTSC (cathepsin C), and among its related pathways are Osteoclast Signaling and Osteoblast Signaling. The drug carbamide peroxide and the compounds clodronate and tenidap have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and endothelial, and related mouse phenotypes are tumorigenesis and cardiovascular system.

Related Diseases for Periodontitis

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Diseases in the Periodontitis family:

Periodontitis 1, Juvenile

Diseases related to Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 337)
idRelated DiseaseScoreTop Affiliating Genes
1aggressive periodontitis32.6FPR1
2periodontal disease32.1ELANE, MMP1, CTSC, LTF, TNFSF11
3arthritis31.5TNFSF11, IL1B, IL1A
4periodontitis 1, juvenile31.4JPD, CTSC
5gingival overgrowth31.3IL1A, MMP1, IL1B
6gingivitis31.3LTF, IL1A, IL1B, ELANE, MMP1, MMP8
7pulpitis31.1MMP1, IL1A
8papillon-lefevre syndrome31.1JPD, CTSC
9oral lichen planus31.0IL1A, MMP1
10haim-munk syndrome30.9JPD, CTSC
11dental caries30.9LTF, MMP8
12osteoporosis30.7TNFSF11, TNFRSF11B, MMP8, IL1RN
13bacterial vaginosis30.7LTF, IL1A, IL1B
14acute myocardial infarction30.6MMP8, TNFSF11, CD14
15oral submucous fibrosis30.5MMP1
16neutropenia30.5IL1RN, ELANE, FCGR3A, FPR1
17prostatitis30.4LTF
18paget disease, juvenile30.4TNFSF11, TNFRSF11B
19coronary artery disease30.2TLR4, MMP8, LTA
20vascular disease30.2ELANE, IL1A, IL1RN, IL1B
21pulmonary emphysema30.1ELANE, MMP8, MMP1
22acne30.0TLR2, IL1A, DEFB1
23vasculitis30.0ELANE, CD14, LTF
24duodenal ulcer29.8IL1RN, LTA, DEFB1
25glomerulonephritis29.8IL1RN, IL1B, ELANE
26thrombocytopenia29.7TLR4, FCGR3A, IL1A
27congenital heart disease29.7MMP1, IL1B, TLR4
28liver cirrhosis29.7CD14, LTF, TNFRSF11B, TLR2
29tuberculosis29.6FPR1, IL1B, TLR4, TLR2
30psoriatic arthritis29.5IL1A, MMP1, IL1B, TNFRSF11B, TNFSF11, TLR2
31inflammatory bowel disease29.5IL1B, TLR4, TLR2, IL1RN
32psoriasis29.4TLR2, LTF, ELANE, IL1B, FCGR3A, IL1A
33cystic fibrosis29.3LTF, TLR4, DEFB1, TNFRSF11B, ELANE
34systemic lupus erythematosus29.2LTF, LTA, IL1RN, FCGR3A, TLR4, TLR2
35allergic asthma29.2CD14, TLR2, TLR4, LTA
36atherosclerosis29.1TLR4, TNFRSF11B, MMP8, MMP1, ELANE, IL1RN
37pneumonia28.9MMP8, ELANE, TLR4, IL1B, TLR2, DEFB1
38asthma28.9TLR2, MMP8, ELANE, IL1B, DEFB1, TLR4
39rheumatoid arthritis28.4LTF, TNFRSF11B, FCGR3A, MMP8, MMP1, ELANE
40periodontosis10.6
41chronic apical periodontitis10.6
42periapical periodontitis10.6
43intervertebral disc disease10.5IL1B
44funisitis10.5MMP8
45endotheliitis10.5
46keratoconjunctivitis sicca10.5LTF
47gingival recession10.5
48periapical granuloma10.5MMP8, TNFSF11
49obesity10.5
50blau syndrome10.5IL1B

Graphical network of the top 20 diseases related to Periodontitis:



Diseases related to periodontitis

Symptoms for Periodontitis

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HPO human phenotypes related to Periodontitis:

id Description Frequency HPO Source Accession
1 autosomal recessive inheritance HP:0000007
2 periodontitis HP:0000704
3 onset HP:0003674

Drugs & Therapeutics for Periodontitis

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Drug clinical trials:

Search ClinicalTrials for Periodontitis

Search NIH Clinical Center for Periodontitis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Periodontitis

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Genetic tests related to Periodontitis:

id Genetic test Affiliating Genes
1 Periodontitis, Chronic22

Anatomical Context for Periodontitis

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MalaCards organs/tissues related to Periodontitis:

31
Bone, Neutrophil, Endothelial, Heart, T cells, Monocytes, Kidney, Testes, Whole blood, Colon, B cells, Tongue, Bone marrow, Liver, Thyroid, Prostate, Nk cells, Brain, Cortex, Smooth muscle, Lung, Breast, Placenta

Animal Models for Periodontitis or affiliated genes

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MGI Mouse Phenotypes related to Periodontitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.1TLR2, TLR4, MMP8, MMP1, ELANE, IL1B
2MP:00053857.7TLR4, TNFRSF11B, IL1RN, IL1B, IL1A, LTA
3MP:00053907.1TLR2, TLR4, TNFSF11, TNFRSF11B, FCGR3A, IL1RN
4MP:00053766.1TLR2, TLR4, TNFSF11, FCGR3A, MMP1, ELANE
5MP:00107686.1DEFB1, TLR2, TLR4, TNFSF11, TNFRSF11B, ELANE
6MP:00053975.9ELANE, FCGR3A, TNFRSF11B, TNFSF11, TLR4, TLR2
7MP:00053875.2LTF, DEFB1, TLR2, TLR4, TNFSF11, TNFRSF11B

Publications for Periodontitis

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Articles related to Periodontitis:

(show top 50)    (show all 3509)
idTitleAuthorsYear
1
Change of scaling-induced proinflammatory cytokine on the clinical efficacy of periodontitis treatment. (25884025)
2015
2
Nonendodontic lesions misdiagnosed as apical periodontitis lesions: series of case reports and review of literature. (24331985)
2014
3
Dental caries experience and periodontal treatment needs of children with autistic spectrum disorder. (25385711)
2014
4
Effect of scaling and root planing combined with systemic doxycycline therapy on glycemic control in diabetes mellitus subjects with chronic generalized periodontitis: a clinical study. (23678391)
2013
5
Periodontitis and chronic kidney disease: a systematic review of the association of diseases and the effect of periodontal treatment on estimated glomerular filtration rate. (23432795)
2013
6
Fluoxetine reduces periodontal disease progression in a conditioned fear stress model in rats. (23425324)
2013
7
Periodontitis and systemic diseases: a record of discussions of working group 4 of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. (23627330)
2013
8
Peripheral arterial disease associated with caries and periodontal disease. (22680302)
2013
9
Effect of Ozonised water on Chronic Periodontitis - A Clinical Study. (24324309)
2013
10
Pivotal role of NOD2 in inflammatory processes affecting atherosclerosis and periodontal bone loss. (24324141)
2013
11
Validation of reported genetic risk factors for periodontitis in a large-scale replication study. (23587006)
2013
12
Diagnosis and management of vertical bony defects in periodontal disease. (22782040)
2012
13
CDC: Half of American adults have periodontal disease. (23256312)
2012
14
Direct recognition of Fusobacterium nucleatum by the NK cell natural cytotoxicity receptor NKp46 aggravates periodontal disease. (22457623)
2012
15
Localized periodontal ligament space widening as the only presentation of scleroderma--reliability recheck. (22707333)
2012
16
AHA statement on periodontal disease and heart disease. (22558948)
2012
17
Effect of periodontal treatment on glycosylated hemoglobin levels in elderly patients with periodontal disease and type 2 diabetes. (22040558)
2011
18
Prevalence of Aggregatibacter actinomycetemcomitans in Sudanese patients with aggressive periodontitis: a case-control study. (21332472)
2011
19
Photodynamic therapy reduces bone resorption and decreases inflammatory response in an experimental rat periodontal disease model. (21651385)
2011
20
Interaction between periodontal disease and systemic secondary amyloidosis: from inflammation to amyloidosis. (21043797)
2011
21
Relationship between saturated fatty acids and periodontal disease. (21505204)
2011
22
Salivary MMP-8, TIMP-1, and ICTP as markers of advanced periodontitis. (20507371)
2010
23
Evaluation of serum levels of C-reactive protein and lipid profiles in patients with chronic periodontitis and/or coronary heart disease in an ethnic Han population. (20213025)
2010
24
SNPs of Fc-gamma receptor genes and chronic periodontitis. (20439936)
2010
25
Receptor for advanced glycation endproducts mediates pro-atherogenic responses to periodontal infection in vascular endothelial cells. (20701913)
2010
26
A novel bioactive three-dimensional beta-tricalcium phosphate/chitosan scaffold for periodontal tissue engineering. (19908128)
2010
27
Three-dimensional loading model for periodontal ligament regeneration in vitro. (19216643)
2009
28
Gingival crevicular fluid in the diagnosis of periodontal and systemic diseases]. (19594076)
2009
29
Study on maternal periodontal diseases of the relationships between porphyromonas gingivalis, serum pro-immflamatory mediators and preterm low birth weight]. (20077889)
2009
30
Periodontal status of patients with dentin dysplasia type I: report of three cases within a family. (18597615)
2008
31
Leukocyte adhesion deficiency type 1: an important consideration in the clinical differential diagnosis of prepubertal periodontitis. A case report and review of the literature. (17618138)
2008
32
Risk of aggressive periodontitis in adolescent carriers of the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans in Morocco: a prospective longitudinal cohort study. (18207019)
2008
33
Interleukin-1 and tumor necrosis factor-alpha gene polymorphisms in Turkish patients with localized aggressive periodontitis. (18587204)
2008
34
Dental and periodontal alterations in Berardinelli-Seip syndrome. (17506386)
2007
35
Platelet-rich plasma in combination with bovine derived xenograft in the treatment of generalized aggressive periodontitis: a case report with re-entry. (17957570)
2007
36
Ehlers-Danlos syndrome type VIII: periodontitis, easy bruising, marfanoid habitus, and distinctive facies. (16843123)
2006
37
Periodontal disease in patients from the original Kostmann family with severe congenital neutropenia. (16584360)
2006
38
Identification of epithelial auto-antigens associated with periodontal disease. (15654832)
2005
39
The potential role of interleukin-17 in the immunopathology of periodontal disease. (15811054)
2005
40
Periodontitis, a marker of risk in pregnancy for preterm birth. (15642058)
2005
41
Effects of baicalin on the expression of pro-MMP-1 and MMP-3 in human gingival fibroblasts and periodontal ligament cells]. (15196384)
2004
42
The expression of osteoprotegerin and the receptor activator of nuclear factor kappa B ligand in human periodontal ligament cells cultured with and without 1alpha,25-dihydroxyvitamin D3. (14693199)
2004
43
Specific pro-apoptotic fibronectin fragments modulate proteinase expression in periodontal ligament cells. (15152815)
2004
44
The association of interleukin-1 gene polymorphisms with the susceptibility to chronic periodontitis in Uighur]. (12362317)
2002
45
Association of interleukin-1 gene polymorphisms with early-onset periodontitis. (10983602)
2000
46
A cross-sectional study into the prevalence of root caries in periodontal maintenance patients. (9923507)
1999
47
Effects of parathyroid hormone and cytokines on prostaglandin E synthesis and bone resorption by human periodontal ligament fibroblasts. (2176076)
1990
48
Phosphotyrosine phosphatase activity of human periodontal ligament fibroblasts (HPLF)]. (2134890)
1990
49
Autogenous transplants in the treatment of juvenile periodontitis (periodontosis). (6957470)
1982
50
Periodontal changes during chronic benign granulocytopenia in childhood. A case report. (1055727)
1975

Variations for Periodontitis

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Expression for genes affiliated with Periodontitis

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Search GEO for disease gene expression data for Periodontitis.

Pathways for genes affiliated with Periodontitis

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Pathways related to Periodontitis according to GeneCards Suite gene sharing:

(show all 43)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0TNFSF11, TNFRSF11B
210.0TNFRSF11B, TNFSF11
3
Show member pathways
9.7ELANE, MMP1, MMP8
49.6CD14, IL1B, IL1A
59.6CD14, TLR4
6
Show member pathways
9.6IL1A, IL1B, IL1RN
7
Show member pathways
IL-1 Signaling Pathway36
IL1-mediated signaling events36
9.6IL1A, IL1B, IL1RN
89.5TNFRSF11B, TNFSF11, IL1A, IL1B
99.4TLR4, IL1B, IL1A
109.3LTA, IL1A, IL1B
11
Show member pathways
9.3LTA, IL1A, IL1B
129.3TLR4, MMP1, TLR2
139.2TNFRSF11B, FCGR3A, IL1B, TNFSF11, IL1A
149.2TLR2, TLR4, IL1B
159.2TLR2, TLR4, IL1B
16
Show member pathways
9.2TLR4, IL1B, TLR2
17
Show member pathways
Immune response MIF in innate immunity response58
9.1TLR4, IL1B, IL1A, CD14
189.1TLR4, CD14, IL1B, IL1A
199.1IL1B, IL1A, CD14, TLR4
20
Show member pathways
9.1IL1A, CD14, TLR4, IL1B
21
Show member pathways
9.0IL1A, TLR4, TLR2, IL1B
229.0TNFSF11, TLR4, TLR2, IL1B
238.9TLR4, FCGR3A, CD14, TLR2
24
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.9TLR4, TLR2, IL1B, CD14
258.9TLR4, IL1B, CD14, TLR2
268.9TLR4, IL1B, CD14, TLR2
27
Show member pathways
8.8LTA, IL1B, TLR4, IL1A
28
Show member pathways
8.7TLR2, TLR4, FCGR3A, IL1B, IL1A
29
Show member pathways
8.6TLR2, TLR4, IL1B, IL1A, CD14
30
Show member pathways
8.6TNFRSF11B, CD14, TNFSF11, TLR2, LTA
31
Show member pathways
IL27-mediated signaling events36
8.6IL1B, LTA, TLR2, TLR4
328.5TLR2, IL1A, IL1B, MMP1, TNFSF11, TLR4
338.5LTA, TLR4, TNFSF11, IL1B, CD14
34
Show member pathways
8.4TNFSF11, TNFRSF11B, LTA, TLR2, TLR4
35
Show member pathways
8.4TLR2, LTA, IL1A, IL1B, TLR4
36
Show member pathways
8.4TLR4, IL1B, LTA, TLR2, IL1A
378.4TLR2, TLR4, IL1B, IL1A, CD14, FCGR3A
38
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
8.2IL1B, TLR4, CD14, IL1RN, IL1A, TLR2
39
Show member pathways
8.1TLR4, LTA, TNFSF11, IL1A, TLR2, IL1B
40
Show member pathways
8.0TNFRSF11B, TNFSF11, IL1A, LTA, IL1B, TLR4
41
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
8.0CD14, TLR2, TLR4, IL1A, IL1B, LTA

Compounds for genes affiliated with Periodontitis

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Compounds related to Periodontitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 199)
idCompoundScoreTop Affiliating Genes
1clodronate43 49 1211.6TNFSF11, IL1B, MMP1, MMP8, TNFRSF11B
2tenidap43 2810.5ELANE, IL1B, IL1A, LTF
3ns 39843 5910.2IL1A, IL1B, IL1RN, MMP1, TNFRSF11B, TNFSF11
4gold sodium thiomalate439.2CD14, IL1RN, IL1A, IL1B
5doxycycline43 1210.1LTF, ELANE, MMP1, MMP8, TNFSF11
6muramyl dipeptide43 2810.1TLR2, TLR4, CD14, IL1B
7hbd2439.0DEFB1, IL1B, TLR4, TLR2
8ivig438.7IL1B, IL1RN, FCGR3A, IL1A, LTA
9prostaglandin438.7IL1A, IL1B, IL1RN, TLR2, TNFSF11, TNFRSF11B
10herbimycin a43 599.6FCGR3A, MMP1, IL1B, IL1A, CD14, LTA
11etanercept43 49 1210.6TNFSF11, TNFRSF11B, FCGR3A, MMP1, IL1RN, LTA
12peptidoglycan43 289.6TNFSF11, CD14, IL1B, IL1RN, TLR4, TLR2
13leukotriene b443 59 2410.6TLR2, ELANE, IL1RN, IL1B, LTF, IL1A
14genistein43 28 59 2 24 1213.5TNFSF11, TNFRSF11B, MMP8, MMP1, IL1B, TLR4
15methotrexate49 43 1210.5TLR4, TNFSF11, TNFRSF11B, FCGR3A, IL1RN, IL1B
16hydrocortisone43 2 59 1211.5TNFRSF11B, ELANE, IL1RN, IL1B, IL1A, CD14
17zymosan438.5IL1RN, ELANE, TLR2, TLR4, LTF, CD14
18latex438.5TNFSF11, CD14, IL1RN, TLR2, TLR4, LTF
19aspirin43 49 28 2411.4MMP1, TLR4, IL1B, TNFRSF11B, ELANE, IL1RN
20hyaluronic acid43 249.4ELANE, IL1RN, IL1A, LTA, LTF, IL1B
21neopterin438.4IL1B, ELANE, CD14, LTA, LTF, IL1RN
22infliximab43 49 1210.3IL1RN, MMP1, TNFRSF11B, TNFSF11, IL1B, LTA
23tgf beta1438.3LTA, IL1RN, MMP1, TNFRSF11B, TLR4, IL1B
24il 10438.3TLR2, IL1B, LTA, IL1A, IL1RN, TLR4
25heparin43 28 24 1211.3TNFRSF11B, LTF, CTSC, CD14, TNFSF11, FPR1
26lipoteichoic acid438.2TLR4, IL1RN, LTA, CD14, TLR2, IL1B
27indomethacin43 28 59 1211.1IL1B, FPR1, LTA, TNFSF11, IL1RN, IL1A
28histamine43 28 2410.0IL1RN, TLR4, LTF, IL1B, CTSC, TLR2
29sb 20358043 599.0IL1B, TNFRSF11B, MMP1, IL1A, TNFSF11, IL1RN
30pentoxifylline43 128.9MMP1, ELANE, IL1RN, IL1B, IL1A, FPR1
31mannose437.9TLR2, TLR4, FCGR3A, IL1RN, CD14, LTA
32arachidonic acid43 28 24 1210.8LTA, TNFSF11, TLR4, IL1B, FPR1, TNFRSF11B
33fibrinogen437.8FPR1, TLR4, TNFRSF11B, LTF, MMP8, TLR2
34calcitriol43 59 24 1210.8CD14, LTA, IL1A, IL1B, MMP1, TNFRSF11B
35polymyxin b437.7TNFSF11, TNFRSF11B, IL1RN, IL1B, IL1A, CD14
36superoxide43 248.5TLR2, TLR4, TNFSF11, MMP8, ELANE, IL1RN
37vitamin d437.5IL1A, LTA, TLR2, TLR4, TNFSF11, CD14
38cysteine437.4CTSC, MMP8, TLR2, TLR4, TNFSF11, LTF
39nitric oxide43 24 129.3TLR4, LTA, FPR1, IL1A, IL1B, TLR2
40fmlp437.3LTF, LTA, CD14, FPR1, IL1A, IL1B
41cycloheximide437.3LTA, CD14, IL1A, IL1B, IL1RN, TNFRSF11B
42endotoxin437.1LTF, TLR2, TLR4, ELANE, IL1RN, FPR1
43h2o2437.1MMP1, LTA, TLR2, TLR4, MMP8, ELANE
44rantes436.8DEFB1, TLR2, TLR4, TNFSF11, TNFRSF11B, MMP1
45vegf436.6TLR2, IL1B, TLR4, TNFSF11, TNFRSF11B, LTF
46cyclosporin a43 28 598.6MMP8, MMP1, ELANE, IL1RN, IL1A, FPR1
47dexamethasone43 49 28 129.5IL1RN, MMP1, TNFRSF11B, TNFSF11, TLR4, TLR2
48serine436.4TNFSF11, LTF, IL1RN, MMP8, TLR2, IL1A
49pge2436.3IL1RN, ELANE, MMP1, MMP8, TNFRSF11B, TNFSF11
50retinoic acid43 247.1MMP8, ELANE, IL1RN, IL1B, IL1A, FPR1

GO Terms for genes affiliated with Periodontitis

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Cellular components related to Periodontitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:00301419.5LTF, IL1B, ELANE
2extracellular regionGO:00055767.4LTF, DEFB1, TNFSF11, TNFRSF11B, FCGR3A, MMP8
3extracellular spaceGO:00056157.4TNFSF11, TNFRSF11B, MMP8, IL1RN, IL1B, IL1A

Biological processes related to Periodontitis according to GeneCards Suite gene sharing:

(show all 45)
idNameGO IDScoreTop Affiliating Genes
1ectopic germ cell programmed cell deathGO:003523410.3IL1A, IL1B
2response to magnesium ionGO:003202610.1CD14, TNFRSF11B
3positive regulation of interleukin-2 biosynthetic processGO:004508610.1IL1A, IL1B
4collagen catabolic processGO:003057410.0ELANE, MMP1, MMP8
5fever generationGO:000166010.0IL1RN, IL1B, IL1A
6positive regulation of interleukin-8 biosynthetic processGO:00454169.9ELANE, TLR4
7positive regulation of cytokine secretionGO:00507159.9TLR2, IL1A, CD14
8positive regulation of macrophage cytokine productionGO:00609079.9TLR4, TLR2
9proteolysisGO:00065089.9MMP8, MMP1, ELANE, CTSC
10negative regulation of interleukin-17 productionGO:00327009.8TLR4, TLR2
11positive regulation of JNK cascadeGO:00463309.8IL1B, TNFSF11, TLR4
12positive regulation of tumor necrosis factor biosynthetic processGO:00425359.8TLR4, TLR2
13positive regulation of nitric-oxide synthase biosynthetic processGO:00517709.8TLR2, TLR4
14I-kappaB phosphorylationGO:00072529.7TLR2, TLR4
15extracellular matrix disassemblyGO:00226179.7MMP8, MMP1, ELANE
16extracellular matrix organizationGO:00301989.7TNFRSF11B, MMP8, MMP1, ELANE
17activation of MAPK activityGO:00001879.7FPR1, IL1B, TLR4
18positive regulation vascular endothelial growth factor productionGO:00105759.7IL1A, IL1B
19positive regulation of NF-kappaB import into nucleusGO:00423469.6IL1B, TLR4, TLR2
20positive regulation of interleukin-8 productionGO:00327579.6TLR2, TLR4, IL1B
21lipopolysaccharide-mediated signaling pathwayGO:00316639.6IL1B, TLR4, TLR2
22positive regulation of nitric oxide biosynthetic processGO:00454299.6TLR2, TLR4, IL1B
23positive regulation of interleukin-6 productionGO:00327559.6IL1B, TLR4, TLR2
24cellular response to lipoteichoic acidGO:00712239.6TLR2, TLR4, CD14
25positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.6TLR4, TNFSF11, IL1B, LTF
26positive regulation of tumor necrosis factor productionGO:00327609.6CD14, TLR4, TLR2
27toll-like receptor TLR6:TLR2 signaling pathwayGO:00381249.5TLR2, TLR4, CD14
28toll-like receptor TLR1:TLR2 signaling pathwayGO:00381239.5TLR2, TLR4, CD14
29toll-like receptor 2 signaling pathwayGO:00341349.5TLR2, TLR4, CD14
30positive regulation of chemokine productionGO:00327229.5TLR4, TLR2
31positive regulation of interferon-beta productionGO:00327289.5TLR4, TLR2
32MyD88-dependent toll-like receptor signaling pathwayGO:00027559.5TLR2, TLR4, CD14
33inflammatory responseGO:00069549.5TLR2, IL1B, IL1A, CD14
34defense response to bacteriumGO:00427429.5ELANE, TLR4, DEFB1
35negative regulation of growth of symbiont in hostGO:00441309.5LTA, ELANE, TLR2
36positive regulation of interferon-gamma productionGO:00327299.4LTA, IL1B, TLR4
37toll-like receptor 4 signaling pathwayGO:00341429.4CD14, TLR4, TLR2
38positive regulation of interleukin-10 productionGO:00327339.4TLR4, TLR2
39toll-like receptor signaling pathwayGO:00022249.3CD14, TLR4, TLR2
40positive regulation of NF-kappaB transcription factor activityGO:00510929.2LTF, IL1B, TNFSF11, TLR4, TLR2
41response to lipopolysaccharideGO:00324969.0LTA, IL1RN, ELANE, TLR4
42positive regulation of transcription from RNA polymerase II promoterGO:00459448.9TLR2, TLR4, TNFSF11, IL1B, IL1A
43innate immune responseGO:00450878.9DEFB1, TLR2, TLR4, FCGR3A, CD14
44apoptotic processGO:00069158.7LTA, CD14, IL1A, IL1B, TNFRSF11B, TLR2
45immune responseGO:00069558.0CTSC, DEFB1, TLR2, TLR4, TNFSF11, FCGR3A

Molecular functions related to Periodontitis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1lipoteichoic acid bindingGO:00708919.7CD14, TLR2
2interleukin-1 receptor bindingGO:00051499.7IL1RN, IL1B, IL1A
3lipopolysaccharide bindingGO:00015309.6CD14, TLR4
4serine-type endopeptidase activityGO:00042529.5MMP8, ELANE, CTSC, LTF
5lipopolysaccharide receptor activityGO:00018759.4TLR4, TLR2
6cytokine activityGO:00051259.0LTA, IL1A, IL1B, TNFRSF11B, TNFSF11
7receptor activityGO:00048728.7TLR2, TLR4, TNFRSF11B, FPR1

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