Periodontitis malady

Wikipedia: Periodontitis pron.: /ˌpɛrioʊdɒnˈtaɪtɪs/ or pyorrhea /ˌpaɪəˈriə/ is a set of inflammatory...⁴⁴ more...

MalaCards: Periodontitis, also known as chronic periodontitis, is related to gingivitis and aggressive periodontitis. An important gene associated with Periodontitis is CTSC (cathepsin C), and among its related pathways are MIF Mediated Glucocorticoid Regulation and p38 Signaling. The drug carbamide peroxide and the compounds polysaccharide and nacl have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are homeostasis/metabolism and immune system.

Aliases & Descriptions:

periodontitis 6 7 8 43 chronic periodontitis 6 32 43 chronic periodontitis nos (disorder) 6 chronic pericementitis (disorder) 6

chronic periodontitis (disorder) 6 periodontitis (disorder) 6 chronic pericementitis 6

Diseases related to periodontitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 932)

id	Related Disease	Score	Top Affiliating Genes
1	gingivitis	61.4	PIK3CG, CNR1, CNR2, SELE, SELL, SERPINF2
2	aggressive periodontitis	54.5	SELE, SERPINE1, VEGFA, VDR, VCAM1, MYOM2
3	periodontal disease	54.0	SERPINB2, BSG, NAT2, BGLAP, LAMC2, S100A8
4	prostatitis	50.4	PIK3R1, PIK3CG, KLF10, PDCD1, RETN, CNR1
5	atherosclerosis	49.2	PIK3CG, COG2, KLF10, PDCD1, RETN, CNR1
6	cervicitis	44.0	PIK3CG, PDCD1, CNR1, VWF, GC, SELE
7	lupus erythematosus	44.0	PIK3CG, COG2, PDCD1, RETN, VWF, SFTPD
8	diabetes mellitus	43.3	PIK3R1, PIK3CG, COG2, PDCD1, RETN, CNR1
9	myocardial infarction	42.9	PIK3CG, COG2, KLF10, PDCD1, RETN, CNR1
10	hypoxia	41.3	PIK3R1, PIK3CG, VWF, SELE, SELL, SELP
11	cholesterol	41.1	PIK3R1, PIK3CG, COG2, RETN, CNR1, CNR2
12	coronary heart disease	40.4	COG2, RETN, VWF, SELE, SELL, SELP
13	obesity	40.2	PIK3R1, PIK3CG, COG2, RETN, CNR1, CNR2
14	systemic lupus erythematosus	39.5	PDCD1, VWF, SELE, SERPINH1, VIP, NAT2
15	hypertension	38.1	PIK3R1, PIK3CG, COG2, RETN, CNR1, CNR2
16	acute myocardial infarction	37.9	PIK3CG, COG2, RETN, VWF, SELE, SELL
17	sjogren's syndrome	37.9	PDCD1, RETN, SELE, SELL, VIP, VCAM1
18	immunodeficiency	37.2	PDCD1, SELL, VIP, BPI, BMP6, PADI4
19	neutropenia	36.3	LBP, LACTB, MPO, CD79A, CD14, CD40LG
20	osteolysis	36.2	VEGFA, BMP2, BMP6, BGLAP, JUN, CD36
21	arthritis	36.2	SELL, SERPINA1, VIP, MMP3, FGF1, IL17A
22	type 2 diabetes mellitus	35.3	PIK3R1, COG2, RETN, CNR1, CNR2, VWF
23	osteoporosis	34.9	CNR1, CNR2, GC, SELE, VEGFA, VDR
24	behcet's disease	34.6	VWF, SELE, SELL, SELP, SERPINE1, NAT2
25	insulin resistance	34.4	PIK3R1, PIK3CG, COG2, RETN, CNR1, VWF
26	crohn's disease	34.1	BPI, BMP7, LBP, T, MPO, ITGA1
27	eclampsia	34.1	CNR1, VWF, SELE, SELL, SELP, SERPINB2
28	rheumatoid arthritis	33.8	PADI4, MTHFR, CD40, MICA, IL10, IL1B
29	carcinoma	33.8	PIK3R1, PIK3CG, KLF10, PDCD1, RETN, CNR1
30	pre-eclampsia	33.7	CNR1, VWF, SELE, SELL, SELP, SERPINB2
31	acne	33.5	BMP6, BGLAP, CHKB, MPO, JUN, CD209
32	cadasil	33.3	COG2, RETN, CNR1, VWF, GC, SELL
33	severe congenital neutropenia	33.0	SELL, NAT2, CFH, MPO, ITGB2, FCGR2A
34	systemic lupus erythematosus, association with	32.8	PDCD1, SERPINE1, MS4A2, CD40LG, CDKN3, GSTM1
35	type 1 diabetes mellitus	32.6	PIK3CG, PDCD1, RETN, VDR, BGLAP, CETP
36	alpha 1-antitrypsin deficiency	32.5	GC, SERPINI1, SERPINA1, SERPINE1, SERPINA3, VEGFA
37	gingival overgrowth	32.4	BSG, MS4A1, CD36, ITGA2, ITGAL, MMP1
38	down syndrome	32.1	CNR1, CNR2, SERPINE1, SERPINA3, VIP, VEGFA
39	thalassemia	31.5	VWF, SELE, VDR, VCAM1, BGLAP, MTHFR
40	dyspepsia	31.3	VEGFA, S100A8, CD79A, CD14, IL17A, IL17F
41	dental caries	30.8	LPO, CD79A, MMP8, FGF10, MBL2, ALB
42	root resorption	30.8	BMP2, MMP9, IL1A, IL1B, AMELX, AMELY
43	severe pre-eclampsia	30.2	SELP, SERPINE1, VEGFA, VCAM1, FN1, FGR
44	hypogonadism	30.0	RETN, GC, SERPINE1, VDR, BGLAP, CD36
45	alcoholism	30.0	CNR1, LBR, GSR, IL1RN, GPT, ALDH2
46	leukemia	30.0	PIK3R1, PIK3CG, COG2, KLF10, PDCD1, RETN
47	hepatitis	29.9	SELP, SERPINA1, GUSB, GSR, FASLG, FAS
48	beta thalassemia	29.8	VDR, BGLAP, MTHFR, CD4, ITGB1, INS
49	rickets	29.4	GC, VDR, BGLAP, CD36, MEPE, IGF1
50	marfan syndrome	29.3	BMP6, MTHFR, CD36, MMP14, MMP2, FBN1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 carbamide peroxide

MalaCards organs/tissues related to periodontitis:

²²

MGI Mouse Phenotypes related to periodontitis:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	18.3	PIK3R1, PIK3CG, KLF10, RETN, CNR1, VWF
2	immune system phenotype	MP:0005387	18.2	CNR2, VWF, SELL, SELP, SERPINB2, BSG
3	cellular phenotype	MP:0005384	17.0	PIK3R1, PIK3CG, KLF10, PDCD1, CNR1, VWF
4	hematopoietic system phenotype	MP:0005397	16.0	PDCD1, SERPINB2, BMP4, LGALS9, LDHA, P2RY1
5	behavior/neurological phenotype	MP:0005386	15.4	CNR1, SELE, SELP, SERPINI1, VIP, VEGFB
6	reproductive system phenotype	MP:0005389	15.1	SERPINF1, VIP, VEGFA, VDR, BMP2, BMP7
7	normal phenotype	MP:0002873	14.4	PIK3R1, SELE, SEMA3B, VIP, VEGFA, VCAN
8	integument phenotype	MP:0010771	14.2	PIK3CG, KLF10, CNR1, CNR2, SELP, BDNF
9	digestive/alimentary phenotype	MP:0005381	13.9	VWF, SERPINF1, VEGFA, VDR, BMP2, BMP4
10	limbs/digits/tail phenotype	MP:0005371	13.1	KLF10, VEGFA, VDR, VCAN, BMP2, BMP4
11	tumorigenesis	MP:0002006	13.1	PIK3R1, KLF10, SELL, SERPINE1, LDHA, CDKN2B
12	liver/biliary system phenotype	MP:0005370	13.0	RETN, VEGFA, LPL, BMP4, BMP5, LBP
13	vision/eye phenotype	MP:0005391	12.6	PDCD1, SELE, SELP, SERPINF1, VEGFA, VEGFB
14	craniofacial phenotype	MP:0005382	12.5	BMP4, BMP5, BDNF, LBR, LAMP2, T
15	endocrine/exocrine gland phenotype	MP:0005379	12.4	SELL, BMP5, BCL2L2, CDKN2B, CD40LG, CDC25C
16	no phenotypic analysis	MP:0003012	11.1	PIK3R1, CNR1, NANOG, VEGFA, VCAM1, BMP4
17	other phenotype	MP:0005395	10.9	CNR1, SERPINH1, KDR, LAMC2, CDKN2A, CD40LG
18	embryogenesis phenotype	MP:0005380	10.5	NANOG, BMP5, T, FOS, FGF10, FGFR2
19	hearing/vestibular/ear phenotype	MP:0005377	10.1	VDR, BMP2, BMP4, BMP5, BMP7, PAX5
20	adipose tissue phenotype	MP:0005375	10.0	PIK3R1, RETN, CNR1, SERPINE1, LPL, LBR
21	mortality/aging	MP:0010768	INF	PDCD1, CNR1, VWF, SFTPD, SELE, SELP
22	cardiovascular system phenotype	MP:0005385	INF	PIK3R1, PIK3CG, PDCD1, VWF, SELE, SELL
23	renal/urinary system phenotype	MP:0005367	INF	PDCD1, SELP, BMP4, BMP5, BMP7, LAMC2
24	nervous system phenotype	MP:0003631	INF	PDCD1, CNR1, VWF, SELP, SERPINH1, SERPINF1
25	skeleton phenotype	MP:0005390	INF	PIK3CG, KLF10, CNR1, GC, VEGFA, VDR
26	growth/size phenotype	MP:0005378	INF	PIK3R1, PIK3CG, CNR1, SFTPD, SELE, SELP
27	respiratory system phenotype	MP:0005388	INF	SFTPD, SELL, SELP, LPL, BMP5, BDNF
28	muscle phenotype	MP:0005369	INF	PIK3R1, PIK3CG, PDCD1, SERPINB2, VEGFA, LPL

Articles related to periodontitis:

(show top 50)    (show all 1363)

id	Title	Authors	Year	Affiliating Genes
1	Gingival crevicular fluid IL-6, tPA, PAI-2, albumin l evels following initial periodontal treatment in chronic periodontitis patients with or without type 2 diabetes. (20845058)	KardeA9ler L.... Kinane D.F.	2011	PLAT, IL6, SERPINB2
2	Chemokine monocyte chemoattractant protein-3 in progr essive periodontal lesions in patients with chronic periodontitis. (20151806)	Dezerega A.... Gamonal J.	2010	CCL7
3	Effects of TGF-I^1 on the proliferation and differenti ation of human periodontal ligament cells and a human periodontal ligament stem /progenitor cell line. (20931341)	Fujii S.... Akamine A.	2010	TGFB1
4	In vitro cytokine responses to periodontal pathogens: generalized aggressive periodontitis is associated with increased IL-6 respons e to Porphyromonas gingivalis. (20500696)	Borch T.S.... Nielsen C.H.	2010	IL10
5	Association of single nucleotide gene polymorphism at interleukin-1beta +3954, -511, and -31 in chronic periodontitis and aggressive periodontitis in Dravidian ethnicity. (20059418)	Shete A.R.... Banerjee M.	2010	IL1B
6	Association of gingival crevicular fluid biomarkers d uring periodontal maintenance with subsequent progressive periodontitis. (20151804)	Reinhardt R.A.... Payne J.B.	2010	CD36
7	Functional expression of alpha 7 nicotinic acetylchol ine receptors in human periodontal ligament fibroblasts and rat periodontal tis sues. (20309583)	Wang X.J.... Inoue T.	2010	CHRNA7
8	Periodontal therapy reduces plasma levels of interleukin-6, C-reactive protein, and fibrinogen in patients with severe periodontitis and refractory arterial hypertension. (19405832)	Vidal F.... Fischer R.G.	2009	IL6, CRP
9	Levels of interferon-gamma and transcription factor T-bet in progressive periodontal lesions in patients with chronic periodontitis. (19186970)	Dutzan N.... Gamonal J.	2009	T
10	Circulating matrix metalloproteinase-8 (MMP-8) and MM P-9 are increased in chronic periodontal disease and decrease after non-surgica l periodontal therapy. (19751716)	Marcaccini A.M.... Gerlach R.F.	2009	MMP3, MMP2, MMP8
11	MMP-13 promoter polymorphisms in patients with chroni c periodontitis: effects on GCF MMP-13 levels and outcome of periodontal therap y. (19453573)	Pirhan D.... Berdeli A.	2009	MMP13
12	Multi-center intervention study on glycohemoglobin (HbA1c) and serum, high-sensitivity CRP (hs-CRP) after local anti-infectious periodontal treatment in type 2 diabetic patients with periodontal disease. (19168253)	Katagiri S.... Izumi Y.	2009	CRP, HBA1
13	Salivary cytokine levels in subjects with chronic periodontitis and in periodontally healthy individuals: a cross-sectional study. (19210336)	Teles R.P.... Haffajee A.D.	2009	TNF, IL6, IL2
14	Effect of nonsurgical periodontal therapy on crevicul ar fluid levels of Cathepsin K in periodontitis. (19782963)	Garg G.... Thorat M.K.	2009	CTSK
15	The effect of periodontal treatment on IL-6 production of peripheral blood monocytes in aggressive periodontitis and chronic periodontitis patients. (18523355)	Radvar M.... Arab H.R.	2008	IL6
16	Characterization of progressive periodontal lesions in chronic periodontitis patients: levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and inflammatory cells. (18269660)	Silva N.... Gamonal J.	2008	MMP13, TNFSF11
17	Periodontal debridement as a therapeutic approach for severe chronic periodontitis: a clinical, microbiological and immunological st udy. (18647203)	Del Peloso Ribeiro E.... Casati M.Z.	2008	IL10
18	Interferon-gamma and interleukin-12 gene polymorphisms and their relation to aggressive and chronic periodontitis and key periodontal pathogens. (18672993)	Reichert S.... Schulz S.	2008	IFNG, IL12A
19	Gene polymorphisms of matrix metalloproteinase-2, -9 and -12 in periodontal health and severe chronic periodontitis. (18155181)	Gurkan A.... Berdeli A.	2008	MMP2, MMP9, MMP12
20	A trend of increase in periodontal interleukin-6 expression across patients with neither diabetes nor periodontal disease, patients with periodontal disease alone, and patients with both diseases. (18627438)	Cole C.M.... Huang Y.	2008	MMP8, MMP1, IL6
21	Effects of surgical periodontal therapy on serum levels of TNF-alpha in patients with chronic periodontitis. (18018468)	Yun F.... Jun-Qi L.	2007	TNF
22	Influence of periodontal therapy on the regulation of soluble cell adhesion molecule expression in aggressive periodontitis patients. (17397316)	Pischon N.... Bernimoulin J.P.	2007	ICAM1, SELE, VCAM1
23	Longitudinal study of the association between smoking as a periodontitis risk and salivary biomarkers related to periodontitis. (17470019)	Kibayashi M.... Shizukuishi S.	2007	LTF
24	Studies on periodontitis and analyses of individuals at risk for periodontal diseases. (16838563)	Jansson H.	2006	IL6, IL1A
25	Increased local matrix metalloproteinase-8 expression in the periodontal connective tissues of smokers with periodontal disease. (16928431)	Liu K.Z.... Scott D.A.	2006	MMP8
26	Effect of periodontal treatment on the C-reactive protein and proinflammatory cytokine levels in Japanese periodontitis patients. (15613080)	Yamazaki K.... Seymour G.J.	2005	TNF, IL6, CRP
27	Differential induction of human beta-defensin expression by periodontal commensals and pathogens in periodontal pocket epithelial cells. (16101361)	Vankeerberghen A.... Cuppens H.	2005	IL8, HBB, DEFB1
28	Systemic inflammatory markers, periodontal diseases, and periodontal infections in an elderly population. (16137283)	Bretz W.A.... Newman A.B.	2005	TNF, IL6
29	Adjunctive periodontal treatment with Centella asiatica and Punica granatum extracts in supportive periodontal therapy. (16022023)	Sastravaha G.... Grimm W.D.	2005	IL1B
30	Effect of periodontal therapy on crevicular fluid interleukin-1beta and interleukin-10 levels in chronic periodontitis. (15304296)	Goutoudi P.... Arvanitidou M.	2004	IL10
31	The role of cathepsin C in Papillon-Lefevre syndrome, prepubertal periodontitis, and aggressive periodontitis. (14974080)	Hewitt C.... Thakker N.S.	2004	CTSC
32	Biomaterials in periodontal regenerative surgery: effects of cryopreserved bone, commercially available coral, demineralized freeze-dried dentin, and cementum on periodontal ligament fibroblasts and osteoblasts. (15381784)	DevecioA9lu D.... Nohutcu R.M.	2004	DSPP
33	Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese. (15081423)	Suzuki A.... Kamoi K.	2004	CTSD, EGF, COL1A1
34	Antimicrobial periodontal treatment decreases serum C-reactive protein, tumor necrosis factor-alpha, but not adiponectin levels in patients with chronic periodontitis. (14514239)	Iwamoto Y.... Murayama Y.	2003	TNF, CRP, ADIPOQ
35	Immunohistological and morphometric analysis of inflammatory cells in rapidly progressive periodontitis and adult periodontitis. (11800435)	Hillmann G.... Geurtsen W.	2001	CD36
36	A study of attached and oriented human periodontal ligament cells to periodontally diseased cementum and dentin after demineralizing with neutral and low pH etching solution. (10960015)	Zaman K.U.... Kato H.	2000	DSPP
37	Levels of interleukin-1 beta, -8, and -10 and RANTES in gingival crevicular fluid and cell populations in adult periodontitis patients and the effect of periodontal treatment. (11063385)	Gamonal J.... Silva A.	2000	CD19, IL1B, IL8
38	Relationship between interleukin-6 levels in gingival crevicular fluid and periodontal status in patients with rheumatoid arthritis and adult periodontitis. (11128925)	Bozkurt F.Y.... Bulut S.	2000	IL6
39	Periodontal repair in dogs: effect of rhBMP-2 concent ration on regeneration of alveolar bone and periodontal attachment. (10382580)	WikesjAP U.M.... Wozney J.M.	1999	BMP2
40	Advances in periodontal diagnosis. 7. Proteolytic and hydrolytic enzymes link with periodontitis. (9599884)	Eley B.M.... Cox S.W.	1998	MPO, LTF, GUSB
41	The correlation of gingival crevicular fluid interleukin-8 levels and periodontal status in localized juvenile periodontitis. (9848541)	OzmeriAs N.... Bulut S.	1998	IL8
42	The relationship between gingival crevicular fluid cathepsin B activity and periodontal attachment loss in chronic periodontitis patients: a 2-year longitudinal study. (8884632)	Eley B.M.... Cox S.W.	1996	CTSB
43	Crevicular interleukin-1 beta in moderate and severe periodontitis patients and the effect of phase I periodontal treatment. (7775673)	Hou L.T.... Rossomando E.F.	1995	IL1B
44	Correlation between gingival crevicular fluid dipeptidyl peptidase II and IV activity and periodontal attachment loss. A 2-year longitudinal study in chronic periodontitis patients. (8705828)	Eley B.M.... Cox S.W.	1995	DPP7
45	Humoral immune responses to Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans in adult periodontitis and rapidly progressive periodontitis. (7870466)	Mooney J.... Kinane D.F.	1994	CD79A, IGSF3
46	Salivary collagenase, elastase- and trypsin-like proteases as biochemical markers of periodontal tissue destruction in adult and localized juvenile periodontitis. (8265204)	Ingman T.... Suomalainen K.	1993	MMP8, MMP1, KLK11
47	Cathepsin B/L-, elastase-, tryptase-, trypsin- and dipeptidyl peptidase IV-like activities in gingival crevicular fluid: a comparison of levels before and after periodontal surgery in chronic periodontitis patients. (1356148)	Eley B.M.... Cox S.W.	1992	CTSB
48	Cathepsin B/L-, elastase-, tryptase-, trypsin- and dipeptidyl peptidase IV-like activities in gingival crevicular fluid. A comparison of levels before and after basic periodontal treatment of chronic periodontitis patients. (1355496)	Cox S.W.... Eley B.M.	1992	CTSB
49	The mechanism of the therapeutic effect of periodontal cytomedin on the course of experimental periodontitis (1780921)	Silenko I.u.I.... Zhukova M.I.u.	1991	CP
50	Chemical analysis and immunochemical characterization of serotype-specific antigens from the strains of Actinobacillus actinomycetemcomitans which were frequently found in the periodontal pockets of the patients of localized juvenile periodontitis (2135121)	Amano K.	1990	HLA-B

Genes related to periodontitis according to GeneCards:

(show top 50)    (show all 541)

id	Symbol	Description	Score	GeneCards Section Context
1	CTSC	cathepsin C	11.1	Publications, Summaries
2	PDLA	Periodontitis, localized aggressive	11.0	Publications, Aliases & Descriptions
3	CDKN2B-AS1	CDKN2B antisense RNA 1	11.0	Publications, Summaries
4	JPD	juvenile periodontitis	11.0	Aliases & Descriptions
5	UNC50	unc-50 homolog (C. elegans)	11.0	Publications, Expressions, Aliases & Descriptions
6	ASPN	asporin	11.0	Publications, Aliases & Descriptions, Functions
7	POSTN	periostin, osteoblast specific factor	11.0	Publications, Aliases & Descriptions
8	MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	11.0	Publications
9	IL1A	interleukin 1, alpha	11.0	Publications
10	TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	11.0	Publications
11	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	11.0	Publications
12	LTF	lactotransferrin	11.0	Publications
13	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
14	DEFB1	defensin, beta 1	11.0	Publications
15	IL1B	interleukin 1, beta	11.0	Publications
16	CD14	CD14 molecule	11.0	Publications
17	ELANE	elastase, neutrophil expressed	11.0	Publications
18	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
19	TLR4	toll-like receptor 4	11.0	Publications
20	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
21	TIMP2	TIMP metallopeptidase inhibitor 2	11.0	Publications
22	TLR2	toll-like receptor 2	11.0	Publications
23	TNF	tumor necrosis factor	11.0	Publications
24	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications
25	IL1RAPL2	interleukin 1 receptor accessory protein-like 2	11.0	Publications
26	FCGR3A	Fc fragment of IgG, low affinity IIIa, receptor (CD16a)	11.0	Publications
27	MMP13	matrix metallopeptidase 13 (collagenase 3)	11.0	Publications
28	DSPP	dentin sialophosphoprotein	11.0	Publications
29	GUSB	glucuronidase, beta	11.0	Publications
30	AGER	advanced glycosylation end product-specific receptor	11.0	Publications
31	CTSB	cathepsin B	11.0	Publications
32	DEFB4A	defensin, beta 4A	11.0	Publications
33	IL17A	interleukin 17A	11.0	Publications
34	OSM	oncostatin M	11.0	Publications
35	SLPI	secretory leukocyte peptidase inhibitor	11.0	Publications
36	VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	11.0	Publications
37	BSG	basigin (Ok blood group)	11.0	Publications
38	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
39	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
40	HSPD1	heat shock 60kDa protein 1 (chaperonin)	11.0	Publications
41	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
42	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11.0	Publications
43	S100A8	S100 calcium binding protein A8	11.0	Publications
44	SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	11.0	Publications
45	TIMP1	TIMP metallopeptidase inhibitor 1	11.0	Publications
46	TNFRSF11A	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	11.0	Publications
47	CCL3	chemokine (C-C motif) ligand 3	11.0	Publications
48	CRP	C-reactive protein, pentraxin-related	11.0	Publications
49	IL10	interleukin 10	11.0	Publications
50	IL16	interleukin 16	11.0	Publications

Pathways related to periodontitis according to GeneDecks:

(show top 50)    (show all 191)

id	Pathway	Score	Top Affiliating Genes
1	MIF Mediated Glucocorticoid Regulation36	15.4	BMP2, BMP3, BMP4, BMP5, BMP6, BMP7
2	p38 Signaling36	15.2	VEGFB, BMP2, BMP3, BMP4, BMP5, BMP6
3	MIF Regulation of Innate Immune Cells36	15.0	BMP2, BMP3, BMP4, BMP5, BMP6, BMP7
4	PEDF Induced Signaling36	14.8	SERPINF1, BMP2, BMP3, BMP4, BMP5, BMP6
5	Rheumatoid arthritis20	14.4	VEGFA, VEGFB, JUN, CD86, ITGAL, ITGB2
6	Glucocorticoid Receptor Signaling36	14.1	BMP2, BMP3, BMP4, BMP5, BMP6, BMP7
7	Immune System38	13.9	PDCD1, VCAM1, LBP, CD79A, CD40, CDH1
8	Phagosome20	13.5	SFTPD, RAB5C, LAMP2, MPO, CD209, CD36
9	MAPK Family Pathway36	13.2	PIK3R1, VEGFB, BMP2, BMP3, BMP4, BMP5
10	JAK-STAT Pathway36	13.2	PIK3R1, VEGFB, BMP2, BMP3, BMP4, BMP5
11	Inhibition of Matrix Metalloproteinases36	12.9	SDC2, MMP1, MMP10, MMP12, MMP13, MMP14
12	Hematopoietic cell lineage20	12.9	MS4A1, CD36, CD14, CD4, CD1A, CD19
13	RAR-Gamma-RXR-Alpha Degradation36	12.8	BMP2, BMP3, BMP4, BMP5, BMP7, IL11
14	Influenza A20	12.7	PIK3R1, PIK3CG, JUN, IRF7, IL12A, IL12B
15	PAK Pathway36	12.7	PIK3R1, VEGFB, BMP2, BMP3, BMP4, BMP5
16	Amoebiasis20	12.7	PIK3R1, SERPINB2, RAB5C, LAMC2, CD14, ITGB2
17	Molecular Mechanisms of Cancer36	12.5	PIK3R1, PIK3CG, BMP2, BMP3, BMP4, BMP5
18	Regulation of eIF4 and p70S6K36	12.4	PIK3R1, BMP2, BMP3, BMP4, BMP5, CD4
19	Chemokine Signaling36	12.3	PIK3R1, JUN, FOS, IL8, MAPK8, MAPK3
20	Intestinal immune network for IgA production20	12.2	CD86, CD40LG, CD40, IL10, IL2, IL4
21	Toxoplasmosis20	12.1	PIK3R1, PIK3CG, LAMC2, CD40LG, CD40, ITGB1
22	Staphylococcus aureus infection20	12.0	SELP, CFH, ITGAL, ITGB2, FPR1, FCAR
23	THC Differentiation Pathway36	12.0	CD86, IL10, IL12A, IL12B, IL12RB2, IL18
24	Angiogenesis3	11.9	VEGFB, KDR, JAG1, ITGB1, MMP2, MMP7
25	Type I diabetes mellitus20	11.9	CD86, INS, IL12A, IL12B, IL1A, IL1B
26	Chagas disease (American trypanosomiasis)20	11.8	PIK3R1, PIK3CG, SERPINE1, JUN, FOS, IL10
27	Colorectal Cancer Metastasis36	11.6	PIK3R1, FZD9, CDH1, MMP1, MMP12, MMP14
28	Bacterial infections in CF airways41	11.6	SFTPD, LBP, IL1R1, CTSB, CTSL1, TLR1
29	Phospholipase-C Pathway36	11.4	VEGFB, BMP2, BMP3, BMP4, BMP5, BMP6
30	HMGB1 Pathway36	10.9	PIK3R1, JUN, FOS, IL1A, IL1B, IL1R1
31	Transcription Role of VDR in regulation of genes involved in osteoporosis10	10.8	VDR, BGLAP, JUN, FOS, IL1A, IL1B
32	PTEN Pathway36	10.7	PIK3R1, VEGFB, BMP2, BMP3, BMP4, BMP5
33	Activation of PKA through GPCR36	10.6	VEGFB, BMP2, BMP3, BMP4, BMP5, BMP6
34	GnRH Signaling36	10.6	LAMC2, ATF4, JUN, ITGA1, ITGA2, ITGA3
35	Breast Cancer Regulation by Stathmin136	10.5	PIK3R1, VEGFB, BMP2, BMP3, BMP4, BMP5
36	Apoptotic Pathways in Synovial Fibroblasts36	10.2	PIK3R1, VEGFB, BMP2, BMP3, BMP4, BMP5
37	Activation of cAMP-Dependent PKA36	10.2	VEGFB, BMP2, BMP3, BMP4, BMP5, BMP6
38	IP3 Pathway36	10.2	PIK3R1, VEGFB, BMP2, BMP3, BMP4, BMP5
39	Nuclear Receptor Activation by Vitamin-A36	10.2	VEGFB, BMP2, BMP3, BMP4, BMP5, BMP6
40	cAMP Pathway36	10.1	PIK3R1, VEGFB, BMP2, BMP3, BMP4, BMP5
41	Rap1 Pathway36	10.0	VEGFB, BMP2, BMP3, BMP4, BMP5, BMP6
42	Pathways in cancer20	9.9	PIK3R1, PIK3CG, VEGFA, VEGFB, BMP2, BMP4
43	Ras Pathway36	9.9	PIK3R1, VEGFB, BMP2, BMP3, BMP4, BMP5
44	Nanog in Mammalian ESC Pluripotency36	9.8	NANOG, VEGFB, BMP2, BMP3, BMP4, BMP5
45	Renin-Angiotensin Pathway36	9.7	PIK3R1, VEGFB, VCAM1, BMP2, BMP3, BMP4
46	Telomerase Components in Cell Signaling36	9.7	VEGFB, BMP2, BMP3, BMP4, BMP5, BMP6
47	CREB Pathway36	9.6	PIK3R1, VEGFB, BMP2, BMP3, BMP4, BMP5
48	PPAR Pathway36	9.3	PIK3R1, VEGFB, BMP2, BMP3, BMP4, BMP5
49	Cellular Apoptosis Pathway36	9.3	PIK3R1, VEGFB, BMP2, BMP3, BMP4, BMP5
50	Mitochondrial Apoptosis36	9.0	PIK3R1, VEGFB, BMP2, BMP3, BMP4, BMP5

Compounds related to periodontitis according to GeneDecks:

(show top 50)    (show all 477)

id	Compound	Score	Top Affiliating Genes
1	polysaccharide32	14.5	SFTPD, SELE, SELL, SELP, SERPINF2, SERPINA1
2	nacl32	13.9	SERPINA3, VCAN, BMP7, BDNF, CHKB, CFH
3	mannose32	13.8	SFTPD, CD209, CD79A, CD86, CD14, CD4
4	glyceraldehyde 3-phosphate32	13.5	LDHA, S100A9, MMP1, MMP13, MMP14, MMP3
5	procollagen32	13.4	SERPINH1, BMP2, BMP6, BGLAP, PAX5, CD36
6	ethanol32 34 9 18 9	17.0	SERPINA1, BPI, BMP7, BDNF, CHRNA7, LBR
7	chondroitin sulfate32 18	14.0	GC, VCAN, BMP6, CD36, CD44, MMP13
8	genistein32 9 18 9	15.9	PIK3R1, PIK3CG, SELE, SELL, SELP, SERPINE1
9	1,25 dihydroxy vitamin d332	12.7	GC, VDR, BMP2, BMP6, BGLAP, S100A9
10	threonine32	12.6	BMP2, CHRNA7, CDKN2B, CD4, CDC25C, FGFR2
11	sucrose32 9 18 9	15.5	BSG, LBP, LAMP2, CDC25C, CD44, CDH1
12	rituximab32 34 9 9	15.4	PAX5, MS4A1, CD79A, CD40LG, CD40, FCGR1A
13	cytochalasin d32 42	13.0	PIK3CG, VWF, SELE, SELL, LPL, VCAM1
14	butyrate32	11.8	VDR, BMP6, MPO, JUN, CD86, CD14
15	batimastat32 42 9 9	14.8	CD36, MMP1, MMP10, MMP12, MMP13, MMP14
16	gp 13032	11.7	PIK3R1, VIP, BMP4, BMP6, CDC25C, IL13
17	troglitazone32 42 9 9	14.7	PIK3CG, SELE, SERPINE1, LPL, VDR, VCAM1
18	cyclic amp32 18	12.6	PIK3R1, CNR1, CNR2, SFTPD, SERPINB2, BDNF
19	methylcellulose32	11.6	BMP2, CD14, CDH1, FGF2, IL11, IL1A
20	progesterone32 42 9 18 9	15.5	PIK3R1, SERPINB2, SERPINA3, BSG, BMP2, BMP4
21	retinoid32	11.5	SELL, VDR, BMP2, BMP4, BMP6, S100A8
22	wortmannin32 42	12.4	PIK3R1, PIK3CG, VCAM1, BMP2, BDNF, KDR
23	bromodeoxyuridine32	11.4	PIK3R1, BMP4, BMP6, BMP7, BDNF, LBR
24	cyclophosphamide32 34 9 9	14.3	MS4A1, ITGAL, ITGB2, MBL2, F9, TRB@
25	candesartan32 9 9	13.3	SELP, SERPINE1, VEGFA, MMP1, MMP2, CCL2
26	alpha tocopherol32	11.3	LPL, VCAM1, BGLAP, CHKB, MTHFR, SAA4
27	sp 60012532 42	12.3	PIK3CG, VCAM1, CD40, MMP1, MMP13, IL13
28	5-hydroxytryptamine32	11.2	CNR1, SERPINE1, VIP, BMP6, CHRNA7, CDKN3
29	thromboxane a232 18	12.2	VWF, SELP, P2RY1, ITGA2, HSPG2, TNFSF11
30	egcg32	11.2	PIK3CG, IL1A, APP, MAPK8, MAPK3, MAPK14
31	guanine32 9 18 9	14.1	CNR1, VWF, SELE, VIP, LPL, VDR
32	nicotine32 34 9 9	14.0	SELL, BMP2, GPT, PTHLH, CYP2E1, KRT1
33	sodium nitroprusside32	11.0	VWF, VIP, BMP6, CD40, IL12B, IL13
34	deoxypyridinoline32	10.9	VDR, BGLAP, PAX5, CD36, MMP3, IL11
35	prostaglandin f2alpha32	10.8	SERPINE1, VIP, LPL, SAA4, CD44, MMP1
36	trastuzumab32 34 9 9	13.7	PIK3R1, PIK3CG, KDR, CDKN3, FGFR2, FCGR1A
37	inositol32	10.7	LPL, BDNF, LBR, CD79A, INPP5D, FGF1
38	folate32	10.5	VWF, SELE, SERPINA3, NAT2, VDR, VCAM1
39	isoproterenol32 9 9	12.5	PIK3R1, SELL, LBR, ITGAL, FGF2, IL13
40	theophylline32 9 18 9	13.5	SELL, SELP, LPL, CHKB, CD79A, CD40LG
41	okadaic acid32 42	11.4	PIK3R1, SERPINB2, BMP6, LBR, JUN, CDC25C
42	betacarotene32	10.4	VWF, SERPINA3, NAT2, LPL, MTHFR, CETP
43	ibmx32	10.4	VIP, LPL, VCAM1, BMP2, BDNF, CDKN3
44	valine32	10.2	SERPINA3, VIP, LPL, BDNF, MTHFR, CETP
45	lactacystin32	10.2	PIK3CG, SELE, VDR, JUN, CD4, CDC25C
46	resveratrol32 9 18 9	12.9	PIK3CG, BSG, VEGFA, VDR, BMP2, JUN
47	paclitaxel32 34 9 9	12.6	PIK3CG, VEGFA, BMP6, BDNF, KDR, CDKN2A
48	imatinib32 34 9 9	12.6	PIK3R1, PIK3CG, SELL, VIP, VEGFA, BMP6
49	gf 109203x32 42	10.5	PIK3CG, VEGFA, JUN, CDKN3, MMP1, MMP13
50	estrogen32	INF	PIK3R1, COG2, KLF10, RETN, VWF, GC

Cellular components related to periodontitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:005886	20.1	KCNK2, CNR2, CNR1, PDCD1, PIK3CG, PIK3R1
2	extracellular region	GO:005576	19.7	TGFBI, EDN1, A2M, KLK3, KLK11, LTF
3	integral to plasma membrane	GO:005887	15.5	CD40, SELP, SELL, CNR2, CNR1, BPI
4	external side of plasma membrane	GO:009897	13.4	CXCR4, CXCR3, CXCL12, CXCL10, TLR4, TLR2
5	cell surface	GO:009986	13.3	NTRK2, FGFR2, FGF10, MICA, MMP25, ITGB1
6	platelet alpha granule lumen	GO:031093	10.6	HGF, FN1, MMRN1, VEGFB, VEGFA, SERPINE1
7	proteinaceous extracellular matrix	GO:005578	INF	POSTN, AMELY, AMELX, FBN2, FBN1, FBLN5
8	extracellular space	GO:005615	INF	GDF5, HGFAC, HGF, ADIPOQ, C5, KNG1
9	extracellular matrix	GO:031012	INF	VWF, EMILIN1, SLPI, POSTN, SOST, SOD1

Biological processes related to periodontitis according to GeneDecks:

(show top 50)    (show all 78)

id	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:006955	17.2	CNR2, BPI, BMP6, MS4A1, CD86, CD4
2	inflammatory response	GO:006954	16.1	PIK3CG, CNR2, SELE, SELP, SERPINA3, BMP2
3	signal transduction	GO:007165	14.5	PDCD1, VDR, RALA, LGALS9, CHRNA7, S100A9
4	cell-cell signaling	GO:007267	13.9	KLF10, SEMA3B, BMP2, BMP3, S100A9, CD86
5	chemotaxis	GO:006935	13.4	RALA, S100A8, S100A9, FPR1, FGF2, IL4
6	cytokine-mediated signaling pathway	GO:019221	13.1	VCAM1, CD44, IRAK3, IRF7, FCGR1A, IL12RB2
7	extracellular matrix organization	GO:030198	13.1	SERPINH1, MMP1, MMP10, MMP13, MMP14, MMP2
8	response to hypoxia	GO:001666	13.0	SERPINA1, VEGFA, VCAM1, BMP2, SDC2, CHRNA7
9	innate immune response	GO:045087	12.9	PIK3CG, SFTPD, LBP, CFH, JUN, CD209
10	positive regulation of NF-kappaB transcription factor activity	GO:051092	12.9	CD40, IRAK3, INS, IL1B, IL6, IL6R
11	cellular response to lipopolysaccharide	GO:071222	12.7	SERPINE1, LBP, CD36, CD14, IL10, IL12B
12	cell adhesion	GO:007155	12.7	VWF, SELL, SELP, VCAM1, VCAN, BGLAP
13	response to lipopolysaccharide	GO:032496	12.7	CNR1, CNR2, SELE, SELP, SERPINA1, LBP
14	blood coagulation	GO:007596	12.4	PIK3R1, PIK3CG, VWF, SELL, SELP, SERPINF2
15	positive regulation of apoptotic process	GO:043065	12.2	CNR1, BMP2, BMP4, ITGB1, MMP9, INPP5D
16	negative regulation of growth of symbiont in host	GO:044130	12.2	LBP, CD36, IL10, IL12B, MBL2, IFNG
17	response to glucocorticoid stimulus	GO:051384	12.2	SERPINF1, SERPINE1, BGLAP, IL10, IL1B, IL1RN
18	positive regulation of ERK1 and ERK2 cascade	GO:070374	12.2	SERPINF2, VEGFB, BMP2, BMP4, KDR, P2RY1
19	positive regulation of tumor necrosis factor production	GO:032760	12.2	LBP, CD36, CD14, IL12B, IL18, IL23A
20	cell surface receptor signaling pathway	GO:007166	12.1	BSG, UNC50, P2RY1, JMJD6, CD36, CD14
21	interferon-gamma-mediated signaling pathway	GO:060333	12.1	VCAM1, CD44, IRF7, FCGR1A, IFNG, IFNGR1
22	positive regulation of interferon-gamma production	GO:032729	12.0	CD40LG, IL12A, IL12B, IL12RB2, IL18, IL1B
23	lipopolysaccharide-mediated signaling pathway	GO:031663	11.9	LBP, IL18, IL1B, MAPK3, MAPK14, CCL2
24	response to drug	GO:042493	11.9	LPL, BGLAP, BDNF, JUN, CDH1, ITGB1
25	defense response to Gram-positive bacterium	GO:050830	11.9	LBP, CD36, MMP7, FGR, IL12A, IL6
26	cellular response to interleukin-1	GO:071347	11.8	MMP9, IL17A, IL8, CCL2, CCL3, CCL5
27	aging	GO:007568	11.7	CNR1, SERPINF1, VDR, VCAM1, P2RY1, JUN
28	negative regulation of apoptotic process	GO:043066	11.6	PIK3CG, SERPINE1, VEGFA, BMP4, BMP5, KDR
29	positive regulation of cell migration	GO:030335	11.6	VEGFA, BMP2, KDR, ITGB1, MMP14, INS
30	positive regulation of inflammatory response	GO:050729	11.6	SERPINE1, IL12B, IL18, IL2, IL23A, CCR2
31	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	11.5	VEGFA, VEGFB, CD36, CD4, CD44, ITGB1
32	defense response to Gram-negative bacterium	GO:050829	11.5	SELP, SERPINE1, LBP, CD4, MMP7, IL12B
33	positive regulation of transcription from RNA polymerase II promoter	GO:045944	11.5	SERPINF2, SERPINE1, NANOG, VEGFA, VDR, BMP2
34	activation of MAPK activity	GO:000187	11.5	CHRNA7, ITGA1, FPR1, FGF10, FGF2, IL1B
35	positive regulation of nitric oxide biosynthetic process	GO:045429	11.4	INS, IL1B, IFNG, ICAM1, HSP90AA1, HRH1
36	platelet activation	GO:030168	11.4	PIK3R1, PIK3CG, VWF, SELP, SERPINF2, SERPINA1
37	platelet degranulation	GO:002576	11.3	VWF, SELP, SERPINF2, SERPINA1, SERPINE1, VEGFA
38	angiogenesis	GO:001525	11.2	PIK3CG, SERPINE1, VEGFA, KDR, JUN, JAG1
39	skeletal system development	GO:001501	11.2	KLF10, VDR, BMP2, BMP3, BMP5, BMP6
40	positive regulation of angiogenesis	GO:045766	11.2	SERPINE1, VEGFA, KDR, CHRNA7, MMP9, FGF1
41	anti-apoptosis	GO:006916	11.2	SERPINB2, VEGFB, BDNF, BCL2L10, BCL2L2, MPO
42	negative regulation of cell proliferation	GO:008285	11.1	KLF10, VDR, BMP2, BMP4, BMP5, JUN
43	positive regulation of chemokine production	GO:032722	10.9	LBP, IL18, IL6, IL6R, TNF, HIF1A
44	positive regulation of cell proliferation	GO:008284	10.8	VIP, VEGFA, KDR, SCXA, CHRNA7, T
45	positive regulation of smooth muscle cell proliferation	GO:048661	10.8	SERPINF2, BMP4, JUN, IL13, IL6, IL6R
46	positive regulation of MAPK cascade	GO:043410	10.4	KDR, CD36, ITGB1, INS, FGF10, FGFR2
47	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.2	SELP, KDR, INS, FGR, CCL5, IGF1
48	positive regulation of protein kinase B signaling cascade	GO:051897	9.5	PIK3CG, VEGFB, INS, CCL3, IGF2, IGF1
49	ossification	GO:001503	INF	BMP3, BMP5, BMP7, MMP8, MMP9,
50	response to mechanical stimulus	GO:009612	INF	BMP2, BMP4, BGLAP, P2RY1, JUN, MMP9

Molecular functions related to periodontitis according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	18.2	STATH, SLC6A4, RUNX2, RRAGA, RRAGB, PECAM1
2	cytokine activity	GO:005125	13.9	FGF2, IL10, IL11, IL12A, IL12B, IL13
3	receptor activity	GO:004872	12.8	CALCR, TNFRSF11A, TNFRSF11B, PLXNB1, PLXNC1, NOTCH2
4	protein homodimerization activity	GO:042803	12.3	MAF, NFKB1, PDGFA, PDGFB, PDGFC, ACVR1
5	receptor binding	GO:005102	12.2	NOS2, PLXNC1, TNFSF13B, TNFSF10, HLA-B, HLA-A
6	chemokine activity	GO:008009	12.1	CXCL10, CXCL12, CXCL13, CXCL16, CXCL3, CXCL6
7	growth factor activity	GO:008083	11.9	IL7, TGFB1, OSM, CXCL12, CSF1, CSF2
8	protein heterodimerization activity	GO:046982	11.5	AGTR1, HIF1A, HEXA, EGFR, PDGFB, PDGFA
9	heparin binding	GO:008201	11.3	SELL, SELP, VEGFA, VEGFB, LPL, TNXB
10	collagen binding	GO:005518	11.3	SPARC, COL14A1, PDGFA, PDGFB, DSPP, DPP4
11	protease binding	GO:002020	10.9	TNF, TNFRSF1A, ELANE, DPP4, CST3, CSTA