MCID: PRD008
MIFTS: 67

Periodontitis

Categories: Rare diseases, Blood diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Periodontitis

MalaCards integrated aliases for Periodontitis:

Name: Periodontitis 12 72 28 41 14 69
Chronic Pericementitis 12
Chronic Periodontitis 69

Classifications:



External Ids:

Disease Ontology 12 DOID:824
ICD10 32 K05.3
MeSH 41 D010518
NCIt 46 C34918

Summaries for Periodontitis

MalaCards based summary : Periodontitis, also known as chronic pericementitis, is related to periodontitis, aggressive, 1 and periapical periodontitis, and has symptoms including purulent discharge, leukorrhea and tenderness of gums. An important gene associated with Periodontitis is CTSC (Cathepsin C), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Ethanol and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and endothelial, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 72 Periodontitis, also known as gum disease and pyorrhea, is a set of inflammatory diseases affecting the... more...

Related Diseases for Periodontitis

Diseases in the Periodontitis family:

Periodontitis, Chronic Susceptibility to Localized Juvenile Periodontitis

Diseases related to Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 645)
# Related Disease Score Top Affiliating Genes
1 periodontitis, aggressive, 1 34.5 CTSC IL1A MMP1 MMP8
2 periapical periodontitis 33.8 IL1B MMP8 MMP9 TLR2 TNFRSF11B TNFSF11
3 periodontitis, chronic 33.6 IL1B IL6 MMP1 MMP8 TLR2 TNFRSF11B
4 periodontosis 33.3 CXCL8 MMP9 TLR4 TNFSF11
5 aggressive periodontitis 33.2 CTSC CXCL8 IL10 IL1A IL1B IL6
6 gingivitis 32.6 CXCL8 IL1A IL1B IL6 MMP8 MMP9
7 periodontal disease 31.4 CRP CTSC CXCL8 IL17A IL1A IL1B
8 root resorption 30.9 IL1A IL1B TNFRSF11B TNFSF11
9 gingival overgrowth 30.9 IL1A IL6 MMP1 TIMP1
10 pulpitis 30.5 CXCL8 IL1B IL6 MMP1 TNF
11 apnea, obstructive sleep 30.3 CRP IL6 TNF
12 familial mediterranean fever 30.3 CRP IL1B TNF
13 pulmonary disease, chronic obstructive 30.3 CRP CXCL8 IL6 MMP1 TNF
14 osteoporosis 30.3 CRP IL1A IL1B IL6 TNF TNFRSF11B
15 ischemic heart disease 30.2 CRP IL6 TNF
16 prostatitis 30.2 CXCL8 IL10 IL1B IL6 TNF
17 aphthous stomatitis 30.2 IL10 IL1B IL6 TNF
18 sleep apnea 30.2 CRP CXCL8 IL6 TNF
19 hematopoietic stem cell transplantation 30.0 IL10 IL6 TNF
20 fasciitis 30.0 CXCL8 IL6 TNF
21 palindromic rheumatism 30.0 CRP IL1B TNF
22 arteries, anomalies of 30.0 CRP IL1B IL6 MMP9 TLR9 TNF
23 adult-onset still's disease 29.9 CRP IL1B IL6 TNF
24 peripheral artery disease 29.9 CRP IL6 TNFRSF11B
25 cytomegalovirus infection 29.9 CXCL8 IL10 IL6 TNF
26 duodenal ulcer 29.9 CXCL8 IL1B TNF
27 esophagitis 29.9 CXCL8 IL1B IL6
28 aortic valve disease 2 29.9 CRP TNFRSF11B TNFSF11
29 spondylitis 29.9 CRP IL17A IL6 TNF
30 arthritis 29.8 CXCL8 IL10 IL17A IL1A IL1B IL6
31 brucellosis 29.8 CRP CXCL8 IL10 IL6 TLR4 TNF
32 osteoporotic fracture 29.8 IL6 TNFRSF11B
33 cerebrovascular disease 29.7 CRP IL6 MMP9 TNF
34 arteriosclerosis 29.7 CRP IL10 IL6 MMP9
35 spondyloarthropathy 1 29.7 CRP IL17A TNF TNFRSF11B TNFSF11
36 helicobacter pylori infection 29.6 CXCL8 IL10 IL1B TLR4 TNF
37 gingival disease 29.6 IL1B IL6 MMP1 MMP8 TIMP1
38 pulmonary emphysema 29.6 MMP1 MMP8 MMP9 TIMP1
39 myocarditis 29.6 IL17A IL6 TNF
40 bronchiectasis 29.5 CXCL8 MMP8 TLR2
41 paracoccidioidomycosis 29.4 IL10 IL6 TLR2 TLR4 TNF
42 common variable immunodeficiency 29.4 IL10 IL6 TLR9 TNF
43 glucose metabolism disease 29.3 CRP IL1B IL6 TLR9 TNF
44 bacterial vaginosis 29.3 CXCL8 IL10 IL1A IL1B IL6 TLR2
45 myocardial infarction 29.3 CRP IL10 IL1B IL6 MMP1 MMP9
46 oral squamous cell carcinoma 29.3 CXCL8 MMP1 MMP9 TLR9
47 crohn's disease 29.1 CRP IL10 IL1B IL6 TLR4 TLR9
48 lung disease 29.1 CXCL8 IL10 IL1B MMP9 TLR9 TNF
49 psoriasis 29.0 CXCL8 IL10 IL17A IL1A IL1B IL6
50 interstitial lung disease 29.0 CXCL8 IL10 IL1A IL1B IL6 MMP9

Graphical network of the top 20 diseases related to Periodontitis:



Diseases related to Periodontitis

Symptoms & Phenotypes for Periodontitis

UMLS symptoms related to Periodontitis:


purulent discharge, leukorrhea, tenderness of gums, snoring, halitosis

GenomeRNAi Phenotypes related to Periodontitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 IL10 IL17A IL1A IL1B TNF TNFRSF11B
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 CXCL8 IL10 IL17A IL1A IL1B TNF

MGI Mouse Phenotypes related to Periodontitis:

43 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.31 CTSC IL10 IL17A IL1A IL1B IL6
2 immune system MP:0005387 10.3 CRP CTSC IL10 IL17A IL1A IL1B
3 hematopoietic system MP:0005397 10.28 TNF TNFRSF11B TNFSF11 CTSC IL10 IL17A
4 cardiovascular system MP:0005385 10.24 IL10 IL1A IL1B IL6 MMP9 TIMP1
5 growth/size/body region MP:0005378 10.23 CTSC IL10 IL17A IL1B IL6 MMP9
6 digestive/alimentary MP:0005381 10.08 IL10 IL17A IL6 MMP9 TLR2 TLR4
7 integument MP:0010771 10.02 CTSC IL10 IL1A IL1B IL6 MMP9
8 neoplasm MP:0002006 9.93 IL1A IL1B IL6 MMP1 MMP8 MMP9
9 limbs/digits/tail MP:0005371 9.8 IL10 MMP9 TIMP1 TLR4 TNF TNFRSF11B
10 respiratory system MP:0005388 9.61 IL10 IL17A IL6 MMP9 TIMP1 TLR2
11 skeleton MP:0005390 9.36 IL1B IL6 MMP9 TIMP1 TLR2 TLR4

Drugs & Therapeutics for Periodontitis

Drugs for Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 366)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4,Phase 3 64-17-5 702
2
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 51-43-4 5816
3
Ciprofloxacin Approved, Investigational Phase 4,Phase 1 85721-33-1 2764
4 sodium fluoride Approved Phase 4,Phase 3 7681-49-4
5
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2 22916-47-8 4189
6
Azithromycin Approved Phase 4,Phase 2 83905-01-5 53477736 447043 55185
7
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 26787-78-0 33613 2171
8
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1 443-48-1 4173
9
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 55-56-1 2713 9552079
10
Menthol Approved Phase 4,Early Phase 1 2216-51-5 16666
11
Hexetidine Approved, Investigational Phase 4 141-94-6
12 Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1 329-65-7
13
Simvastatin Approved Phase 4,Phase 2,Phase 3 79902-63-9 54454
14
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-78-2 2244
15
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
16
Montelukast Approved Phase 4 158966-92-8 5281040
17
Ibuprofen Approved Phase 4,Phase 2,Phase 3 15687-27-1 3672
18
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 1,Phase 2 9004-61-9 53477741 24759
19
Alendronate Approved Phase 4,Phase 2,Phase 3 121268-17-5, 66376-36-1 2088
20
Zoledronic acid Approved Phase 4 118072-93-8 68740
21
Iodine Approved, Investigational Phase 4 7553-56-2 807
22
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2 137-58-6 3676
23
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
24
Minocycline Approved, Investigational Phase 4,Phase 3,Phase 1 10118-90-8 5281021
25
Clarithromycin Approved Phase 4,Phase 2,Phase 3 81103-11-9 84029
26
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 564-25-0 54671203
27
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
28
Moxifloxacin Approved, Investigational Phase 4 151096-09-2, 354812-41-2 152946
29
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
30
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
31
Edetic Acid Approved, Vet_approved Phase 4 60-00-4, 62-33-9 6049
32
Povidone-iodine Approved Phase 4 25655-41-8
33
Triclosan Approved, Investigational Phase 4,Phase 3 3380-34-5 5564
34
Povidone Approved Phase 4 9003-39-8
35
Coal tar Approved Phase 4,Phase 3 8007-45-2
36
Testosterone Approved, Investigational Phase 4 58-22-0 6013
37
Methyltestosterone Approved Phase 4 58-18-4 6010
38
Hydrogen peroxide Approved, Vet_approved Phase 4 7722-84-1 784
39
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
40
Lycopene Approved, Investigational, Nutraceutical Phase 4,Phase 1,Phase 2 502-65-8 446925
41
Lactitol Investigational Phase 4 585-86-4 3871
42 Fluorides Phase 4,Phase 3
43 Chlorhexidine gluconate Phase 4,Phase 3,Phase 2,Phase 1
44 Risedronate Sodium Phase 4 115436-72-1
45 calcium channel blockers Phase 4
46 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
47 Coagulants Phase 4,Phase 2,Phase 3,Phase 1
48 Tolonium Chloride Phase 4,Phase 2,Phase 3
49 Topoisomerase Inhibitors Phase 4,Phase 1
50 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 609)

# Name Status NCT ID Phase Drugs
1 Metronidazole and Amoxicillin for the Treatment of Type 2 Diabetic Subjects With Periodontitis Unknown status NCT02135952 Phase 4 MTZ+AMX
2 Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care Unknown status NCT01195493 Phase 4
3 SRP in Combination With PERIOWAVE in Comparison to SRP Alone in Chronic Periodontitis Unknown status NCT00296881 Phase 4
4 Study of Scaling and Root Planing With PerioWave Versus Scaling and Root Planing Alone in Chronic Periodontitis Unknown status NCT00297531 Phase 4
5 Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic Therapy Unknown status NCT01532674 Phase 4
6 Role of Stress Reduction Protocol on Outcome of Periodontal Therapy Unknown status NCT02487862 Phase 4
7 Methodology Antiseptic Application, Influence on Oral Biofilm. Unknown status NCT02267239 Phase 4 essential oils, immersion;Chlorhexidine, immersion;essential oils, mouthwash;chlorhexidine, mouthwash
8 Effect of Actonel on Periodontal Health of Postmenopausal Women Unknown status NCT00594334 Phase 4 Risedronate
9 Periodontal Therapy in Coronary Artery Patients Unknown status NCT01609725 Phase 4
10 The Treatment of Periodontal Diseases Unknown status NCT01318928 Phase 4 Metronidazol
11 Omega-3 Fatty Acids in Chronic Periodontitis. Completed NCT01997853 Phase 4 Omega 3 fatty acid;Placebo
12 Study to Evaluate Clinical Efficacy and Safety of Bio Mineral Toothpaste in Patients With Mild Periodontitis Completed NCT01548469 Phase 4
13 Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis Completed NCT02125812 Phase 4
14 Adjunctive Photodynamic Therapy in Treatment of Chronic Periodontitis Completed NCT01034501 Phase 4
15 Role of Leukotriene Receptor Antagonists in Treatment of Chronic Periodontitis Completed NCT02014532 Phase 4 Montelukast;Placebo
16 Comparison of Moxifloxacin With Ciprofloxacin/Metronidazole on Patients With Chronic Periodontitis Completed NCT00805558 Phase 4 moxifloxacin;Ciprofloxacin plus metronidazole
17 Effect of Scaling and Root Planing Along With Topical Application of Commercially Available Curcuma Longa Gel on Superoxide Dismutase and Malondialdehyde Levels in Saliva of Chronic Periodontitis Patients Completed NCT02442453 Phase 4 Topical application of curenext gel;Placebo
18 Evaluation of Efficacy of Full-mouth Disinfection in Generalized Aggressive Periodontitis Patients Completed NCT02466646 Phase 4 Klorhex® Gel, rinse and sprey
19 Propolis Improves Glycemic Control in Subjects With Type 2 Diabetes and Chronic Periodontitis Completed NCT02794506 Phase 4 Propolis;Placebo
20 The Response of Pathogens to the Respective or Combined Treatment of SRP and Local Minocycline in Chronic Periodontitis Completed NCT02355977 Phase 4 minocycline
21 Role of Herbal Immunomodulators in the Treatment of Chronic Periodontitis Completed NCT01997814 Phase 4 herbal immunomodulator;Placebo
22 Treatment of Chronic Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02734784 Phase 4
23 Simvastatin Gel With Perforated Resorbable Membranes in Treatment of Intrabony Defects in Chronic Periodontitis Completed NCT03419429 Phase 4 Simvastatin
24 Locally Delivered Aloe Vera Gel in the Treatment of Chronic Periodontitis Patients With Diabetes Mellitus Completed NCT02437747 Phase 4 SRP + Aloe
25 Adjunctive Antimicrobial Therapy of Periodontitis: Long-Term Effects on Disease Progression and Oral Microbiological Colonization Completed NCT00707369 Phase 4 Amoxicillin and Metronidazole;Placebo
26 Study of Scaling and Root Planing (SRP) With PerioWave vs. SRP Alone in Chronic Periodontitis Completed NCT00297518 Phase 4
27 Treatment of Aggressive Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02049008 Phase 4
28 Host Modulatory Effects of β-glucan on Localized Aggressive Periodontitis Completed NCT02402296 Phase 4 β-1,3/1,6-D-glucan
29 Effects of the Variation in the Time of Systemic Administration of Metronidazole and Amoxicillin Associated to the Non-surgical Therapy of Chronic Periodontitis. Completed NCT01211223 Phase 4 Administration of Metronidazole plus Amoxicillin
30 Melatonin as an Adjunctive Therapy for Chronic Periodontitis. Completed NCT03368430 Phase 4 Placebo
31 Moxifloxacin in Situ Gel to Treat Periodontal Pocket. Completed NCT02016157 Phase 4 Moxifloxacin
32 "Effect of Scaling and Root Planing on Liver Function Test (Alanine Aminotransferase and Aspartate Aminotransferase) in Systemically Healthy - Chronic Periodontitis Subjects: a Clinical Trial." Completed NCT02583841 Phase 4
33 Treatment of Periodontitis by Conventional 4 Weekly Sections or Within 24 Hours Completed NCT02215460 Phase 4 FMS chlorhexidine rinse;FMS placebo rinse;FMS azithromycin tablets;FMS placebo tablets;QS azithromycin tablets;QS placebo tablets;QS chlorhexidine rinse;QS placebo rinse
34 Evaluation of the Efficacy of Hyaluronic Acid Gel 0.8% Completed NCT03311906 Phase 4 0.8% Hyaluronic Acid
35 Effect on Teeth and Gum Cleaning in Patients With Gum and Kidney Disease Completed NCT02901743 Phase 4
36 Long-term Safety of Minocycline in Patients With Gum Disease Completed NCT00668746 Phase 4 Minocycline HCl microspheres
37 Alternative Antibiotic Regime in the Treatment of GAgP Completed NCT02223702 Phase 4 Amoxicillin;Metronidazole;Moxifloxacin
38 The Use of Erythritol Powder and Metronidazole Gel for the Non-surgical Treatment of Periodontitis Completed NCT02023840 Phase 4 metronidazole gel;placebo
39 EFFECT OF SELECTIVE COX-2 INHIBITOR (ETORICOXIB) ALONG WITH SCALING AND ROOT PLANING (SRP) ON CLINICAL PARAMETERS AND SALIVARY LEVEL OF SUPEROXIDE DISMUTASE IN CHRONIC GENERALIZED PERIODONTITIS A DOUBLE-BLIND, PLACEBO-CONTROLLED, DOUBLE-MASKED RANDOMIZED Completed NCT02149758 Phase 4 Etoricoxib
40 MTZ Plus AMX in the Treatment of Smokers and Non-smokers Completed NCT01837199 Phase 4 Metronidazole plus Amoxicillin
41 Effect of Arthrospira Platensis (Spirulina) as an Adjunct to Scaling and Root Planing on Salivary Antioxidant Levels in Chronic Periodontitis Subjects Completed NCT02886676 Phase 4 Spirulina capsules
42 A Clinical Trial to Study the Effect of Lycopene in Patients With Gum Disease and type2 Diabetes Mellitus Completed NCT02263352 Phase 4 Lycored soft gels Jagsonpal Pharma, Systemic 8mgms/day
43 Impact of Periodontal Treatment on Serum Levels of Hepcidin and Hemoglobin Completed NCT02641210 Phase 4 Albendazole
44 Locally Delivered Doxycycline Adjunct to Nonsurgical Periodontal Therapy. Completed NCT02487186 Phase 4 Doxicicline
45 Sodium Alendronate in Non Surgical Periodontal Therapy Completed NCT02470611 Phase 4 Sodium alendronate
46 Changes of GCF Levels of RANKL and Osteoprotegerin in Postmenopausal Osteoporosis Completed NCT02808988 Phase 4
47 Clarithromycin is an Adjunct to Scaling and Root Planing Completed NCT02359721 Phase 4 tablet clarithromycin 500 mg (Clarino-500) orally
48 Full-mouth and Partial-mouth Scaling and Root Planing in Type 2 Diabetic Subjects Completed NCT02062047 Phase 4 Chlorhexidine
49 Atorvastatin as an Adjunct to DFDBA in Intrabony Defects Completed NCT03009097 Phase 4 DFDBA with atorvastatin
50 Treatment of Intrabony Periodontal Defects With Enamel Matrix Derivatives and Autogenous Bone Graft Completed NCT02218515 Phase 4

Search NIH Clinical Center for Periodontitis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: periodontitis

Genetic Tests for Periodontitis

Genetic tests related to Periodontitis:

# Genetic test Affiliating Genes
1 Periodontitis 28

Anatomical Context for Periodontitis

MalaCards organs/tissues related to Periodontitis:

38
Bone, Neutrophil, Endothelial, Heart, Kidney, Monocytes, Testes

Publications for Periodontitis

Articles related to Periodontitis:

(show top 50) (show all 4202)
# Title Authors Year
1
Molecular basis for immunohistochemical and inflammatory changes during progression of gingivitis to periodontitis. ( 29194785 )
2018
2
Salivary and Serum Antioxidants in Women with Preeclampsia with or Without Periodontal Disease. ( 29391673 )
2018
3
Clinical effect of a dentifrice containing three kinds of bactericidal ingredients on periodontal disease: a pilot study in patients undergoing supportive periodontal therapy. ( 29426362 )
2018
4
Wnt5a suppresses osteoblastic differentiation of human periodontal ligament stem cell-like cells via Ror2/JNK signaling. ( 28681925 )
2018
5
Evaluating periodontal disease misclassification mechanisms under partial-mouth recording protocols. ( 29385644 )
2018
6
Effect of a comprehensive plan for periodontal disease care on oral health-related quality of life in patients with periodontal disease in Taiwan. ( 29384859 )
2018
7
Inflammatory and Oxidative Responses in Pregnancies With Obesity and Periodontal Disease. ( 29343164 )
2018
8
Antimicrobial peptide gene expression in periodontitis patients: a pilot study. ( 29446150 )
2018
9
Comparative analysis of salivary sialic acid levels in patients with chronic obstructive pulmonary disease and chronic periodontitis patients: A biochemical study. ( 29442082 )
2018
10
Methodological issues in assessing the association between periodontitis and caries among adolescents. ( 29446848 )
2018
11
Periodontal bacteria DNA findings in human cardiac tissue - Is there a link of periodontitis to heart valve disease? ( 29197463 )
2018
12
<i>Porphyromonas gingivalis</i> , a periodontitis causing bacterium, induces memory impairment and age-dependent neuroinflammation in mice. ( 29422938 )
2018
13
Efficacy of local phytotherapy in the nonsurgical treatment of periodontal disease: A systematic review. ( 29352465 )
2018
14
Squamous Cell Carcinoma of the Gingiva Mimicking Periodontal Disease: A Diagnostic Challenge and Therapeutic Dilemma. ( 29447319 )
2018
15
Oral Biofilms from Symbiotic to Pathogenic Interactions and Associated Disease -Connection of Periodontitis and Rheumatic Arthritis by Peptidylarginine Deiminase. ( 29441048 )
2018
16
Lipopolysaccharide can modify differentiation and immunomodulatory potential of periodontal ligament stem cells via ERK1,2 signaling. ( 28295277 )
2018
17
Definition of aggressive periodontitis in periodontal research. A systematic review. ( 29226356 )
2018
18
Relationship between sjAPgren syndrome and periodontal status: A systematic review. ( 29325853 )
2018
19
Diagnosis of aggressive periodontitis: A dilemma? ( 29363676 )
2018
20
CCR5I932 (rs333) polymorphism is associated with decreased risk of chronic and aggressive periodontitis: A case-control analysis based in disease resistance and susceptibility phenotypes. ( 28969941 )
2018
21
Periodontitis in ChAcdiak-Higashi Syndrome: An Altered Immunoinflammatory Response. ( 29276776 )
2018
22
Dickkopf-1 may regulate bone coupling by attenuating wnt/I^-catenin signaling in chronic apical periodontitis. ( 29216526 )
2018
23
Impact of aggressive periodontitis and chronic periodontitis on oral health-related quality of life. ( 29451591 )
2018
24
Histological healing after nonsurgical periodontal treatment with enamel matrix derivatives in canine experimental periodontitis. ( 29429056 )
2018
25
Dentists' perspectives on the choice of treatment of teeth with apical periodontitis. ( 29440958 )
2018
26
Localised aggressive periodontitis in a 3-year-old-boy. ( 29332208 )
2018
27
B cell subset distribution is altered in patients with severe periodontitis. ( 29447240 )
2018
28
Risk of colorectal cancer in patients with periodontal disease severity: a nationwide, population-based cohort study. ( 29397431 )
2018
29
Association of Tumor Necrosis Factor-I+ (TNF-I+) Gene Promoter Polymorphisms with Aggressive and Chronic Periodontitis in Eastern Indian population. ( 29449347 )
2018
30
Fulminant presentation of oral mucosal leishmaniasis as severe stomatitis and periodontitis. ( 29380732 )
2018
31
Treatment of intrabony defects with modified perforated membranes in aggressive periodontitis: a 12-month randomized controlled trial. ( 29411112 )
2018
32
The immunopathogenic and immunomodulatory effects of interleukin-12 in periodontal disease. ( 29411897 )
2018
33
A potential role for the silent information regulator 2 homologue 1 (SIRT1) in periapical periodontitis. ( 29363137 )
2018
34
Impact of gingivitis treatment for diabetic patients on quality of life related to periodontal objective parameters: A randomized controlled clinical trial. ( 29197785 )
2018
35
Effect of scaling and root planing on gingival crevicular fluid cytokine/chemokine levels in smokers with chronic periodontitis: A systematic review. ( 29450974 )
2018
36
Zoledronic acid increases the prevalence of medication-related osteonecrosis of the jaw in a dose dependent manner in rice rats (Oryzomys palustris) with localized periodontitis. ( 29289789 )
2018
37
Severe periodontitis and higher cirrhosis mortality. ( 29435316 )
2018
38
Periodontitis in patients with cirrhosis: a cross-sectional study. ( 29439734 )
2018
39
Topical application of glycyrrhetinic acid in the gingival sulcus inhibits attachment loss in lipopolysaccharide-induced experimental periodontitis in rats. ( 29446076 )
2018
40
Morphometric and histopathological evaluation of the effect of grape seed proanthocyanidin on alveolar bone loss in experimental diabetes and periodontitis. ( 29446089 )
2018
41
A cross-sectional study to estimate prevalence of periodontal disease in a population of dogs (Canis familiaris) in commercial breeding facilities in Indiana and Illinois. ( 29346448 )
2018
42
Periodontal Disease Assessed Using Clinical Dental Measurements and Cancer Risk in the ARIC Study. ( 29342298 )
2018
43
Development, optimization and evaluation of curcumin loaded biodegradable crosslinked gelatin film for the effective treatment of periodontitis. ( 29429364 )
2018
44
Association between interleukin-8 levels and chronic periodontal disease: A PRISMA-compliant systematic review and meta-analysis. ( 28562542 )
2017
45
Periodontal Disease and Incident Cancer Risk among Postmenopausal Women: Results from the Women's Health Initiative Observational Cohort. ( 28765338 )
2017
46
Salivary Neuropeptides, Stress and Periodontitis. ( 28914594 )
2017
47
Receiver Operating Characteristic (ROC) Curve-based Prediction Model for Periodontal Disease Updated With the Calibrated Community Periodontal Index. ( 28753099 )
2017
48
Treatment of Plaque-induced Gingivitis, Chronic Periodontitis, and Other Clinical Conditions. ( 29179388 )
2017
49
Comprehensive rehabilitation using dental implants in generalized aggressive periodontitis. ( 29398863 )
2017
50
Combined antioxidant effects of Neem extract, bacteria, red blood cells and Lysozyme: possible relation to periodontal disease. ( 28797303 )
2017

Variations for Periodontitis

Expression for Periodontitis

Search GEO for disease gene expression data for Periodontitis.

Pathways for Periodontitis

Pathways related to Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 CRP CTSC CXCL8 IL10 IL17A IL1A
2
Show member pathways
13.79 CXCL8 IL10 IL17A IL1A IL1B IL6
3
Show member pathways
13.56 CXCL8 IL10 IL17A IL1A IL1B IL6
4
Show member pathways
13.49 CXCL8 IL10 IL17A IL1A IL1B IL6
5
Show member pathways
13.43 CXCL8 IL10 IL17A IL1A IL1B IL6
6
Show member pathways
13.13 CXCL8 IL1A IL1B IL6 TLR2 TLR4
7
Show member pathways
13 CXCL8 IL10 IL17A IL1A IL1B IL6
8
Show member pathways
12.96 CXCL8 IL1A IL1B IL6 TLR2 TLR4
9
Show member pathways
12.87 IL1A IL1B IL6 TIMP1 TLR2 TLR4
10
Show member pathways
12.79 IL1A IL1B TLR2 TLR4 TLR9 TNF
11
Show member pathways
12.78 IL10 IL17A IL1A IL1B IL6 TLR2
12 12.74 IL10 IL17A IL1B TLR2 TLR9 TNF
13
Show member pathways
12.73 IL10 IL17A IL1B IL6 TIMP1 TNF
14
Show member pathways
12.72 CXCL8 IL6 MMP9 TLR2 TLR4 TNF
15
Show member pathways
12.71 CXCL8 IL10 IL1B IL6 TLR2 TLR4
16
Show member pathways
12.59 IL10 IL17A IL1A IL1B IL6 TNF
17
Show member pathways
12.47 CXCL8 IL17A IL1B IL6 MMP1 MMP9
18
Show member pathways
12.46 CXCL8 IL1A IL6 TLR2 TLR4 TLR9
19
Show member pathways
12.44 CXCL8 IL1A IL1B IL6 TLR4 TNF
20
Show member pathways
12.43 IL10 IL1A IL1B TLR2 TLR4 TNF
21
Show member pathways
12.39 CRP IL1B IL6 TNF
22
Show member pathways
12.37 CXCL8 IL1B IL6 TLR2 TLR4 TLR9
23 12.37 IL6 MMP1 MMP9 TLR2 TLR4 TLR9
24 12.36 MMP9 TLR2 TLR4 TNF
25 12.36 CXCL8 IL10 IL1A IL1B IL6 TNF
26 12.33 IL10 IL1A IL1B IL6 TLR2 TLR4
27
Show member pathways
12.32 CXCL8 IL10 IL17A IL1A IL1B IL6
28
Show member pathways
12.29 IL1A IL1B TLR4 TNF
29 12.21 IL1A IL1B TNF TNFRSF11B TNFSF11
30
Show member pathways
12.2 IL1A IL1B TLR2 TLR4 TLR9
31 12.18 IL1A IL1B MMP9 TNF
32 12.18 CXCL8 IL1A IL1B IL6 MMP9 TLR4
33 12.09 CXCL8 IL1A IL1B IL6 TNF
34
Show member pathways
12.09 MMP1 MMP8 MMP9 TIMP1 TNF
35 12.07 IL1B IL6 MMP9 TNF
36 12.06 CXCL8 IL1A IL1B IL6
37 12.06 CXCL8 IL1B TLR4 TNF TNFSF11
38
Show member pathways
12.06 IL17A IL1B IL6 TLR2 TLR4 TLR9
39 12.02 IL1A IL1B IL6 TNF
40 12.02 CXCL8 IL1A IL1B IL6 TLR4
41 12.02 CXCL8 IL10 IL1B IL6 TLR2 TLR4
42
Show member pathways
12 CXCL8 IL17A IL6 TLR4
43
Show member pathways
11.96 CRP IL6 TIMP1 TNFSF11
44 11.94 IL10 IL1B IL6 TLR9 TNF
45
Show member pathways
11.94 IL10 IL17A IL1B IL6 TLR2 TLR4
46 11.93 IL10 IL17A IL1B TNF
47 11.91 CXCL8 IL10 IL17A IL1A IL1B IL6
48 11.88 IL10 IL6 TLR2 TLR4 TLR9 TNF
49 11.85 CXCL8 IL6 MMP1
50 11.85 CXCL8 IL1B IL6 MMP9 TIMP1 TNF

GO Terms for Periodontitis

Cellular components related to Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 CRP CTSC CXCL8 IL10 IL17A IL1A
2 proteinaceous extracellular matrix GO:0005578 9.63 MMP1 MMP8 MMP9 TIMP1 TLR9 TNFRSF11B
3 extracellular space GO:0005615 9.5 CRP CTSC CXCL8 IL10 IL17A IL1A

Biological processes related to Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.96 CXCL8 IL10 IL6 TLR4 TNF
2 regulation of receptor activity GO:0010469 9.96 CXCL8 IL10 IL17A IL1A IL1B IL6
3 defense response to Gram-positive bacterium GO:0050830 9.95 CRP IL6 TLR2 TNF
4 positive regulation of DNA binding transcription factor activity GO:0051091 9.95 IL10 IL1B IL6 TNF TNFSF11
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.95 IL1B IL6 TLR2 TLR4 TLR9 TNF
6 response to organic substance GO:0010033 9.93 CTSC IL10 TIMP1 TNF
7 defense response to Gram-negative bacterium GO:0050829 9.92 IL6 TLR4 TLR9
8 extracellular matrix disassembly GO:0022617 9.92 MMP1 MMP8 MMP9 TIMP1
9 apoptotic signaling pathway GO:0097190 9.91 TLR4 TNF TNFRSF11B
10 positive regulation of inflammatory response GO:0050729 9.91 TLR2 TLR4 TLR9
11 collagen catabolic process GO:0030574 9.9 MMP1 MMP8 MMP9
12 response to glucocorticoid GO:0051384 9.9 IL10 IL6 TNF
13 positive regulation of JNK cascade GO:0046330 9.89 IL1B TLR4 TLR9 TNF TNFSF11
14 positive regulation of tumor necrosis factor production GO:0032760 9.88 TLR2 TLR4 TLR9
15 toll-like receptor signaling pathway GO:0002224 9.87 TLR2 TLR4 TLR9
16 positive regulation of interferon-gamma production GO:0032729 9.87 IL1B TLR4 TNF
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.86 IL1B TLR4 TNF
18 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.85 IL1A IL1B TNF
19 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.84 TLR2 TLR4 TLR9
20 lipopolysaccharide-mediated signaling pathway GO:0031663 9.84 IL1B TLR2 TLR4 TNF
21 positive regulation of cytokine secretion GO:0050715 9.83 IL10 IL1A TNF
22 positive regulation of interferon-beta production GO:0032728 9.83 TLR2 TLR4 TLR9
23 positive regulation of interleukin-12 production GO:0032735 9.83 TLR2 TLR4 TLR9
24 negative regulation of interleukin-6 production GO:0032715 9.83 IL10 TLR4 TLR9 TNF
25 positive regulation of interleukin-8 production GO:0032757 9.83 IL1B TLR2 TLR4 TLR9 TNF
26 positive regulation of interleukin-10 production GO:0032733 9.82 TLR2 TLR4 TLR9
27 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.8 IL10 MMP9 TNF
28 positive regulation of osteoclast differentiation GO:0045672 9.8 IL17A TNF TNFSF11
29 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.77 TLR2 TLR4 TLR9
30 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.77 IL10 IL1B TNF
31 positive regulation of NF-kappaB import into nucleus GO:0042346 9.77 IL1B TLR2 TLR4 TLR9 TNF
32 I-kappaB phosphorylation GO:0007252 9.76 TLR2 TLR4 TLR9
33 response to molecule of bacterial origin GO:0002237 9.76 CXCL8 IL10 TLR2 TLR9
34 regulation of cytokine secretion GO:0050707 9.75 TLR2 TLR4 TLR9
35 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.74 IL1A IL1B
36 cellular response to lipoteichoic acid GO:0071223 9.74 TLR2 TLR4
37 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.74 IL1B TLR9
38 negative regulation of lipid storage GO:0010888 9.74 CRP IL6 TNF
39 positive regulation of chemokine biosynthetic process GO:0045080 9.73 IL1B TNF
40 immune response GO:0006955 9.73 CTSC CXCL8 IL10 IL17A IL1A IL1B
41 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.72 TLR4 TNF
42 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.72 IL10 TIMP1
43 endothelial cell apoptotic process GO:0072577 9.72 IL10 TNF
44 regulation of establishment of endothelial barrier GO:1903140 9.72 IL1B TNF
45 positive regulation of chemokine production GO:0032722 9.72 IL6 TLR2 TLR4 TLR9 TNF
46 ectopic germ cell programmed cell death GO:0035234 9.71 IL1A IL1B
47 positive regulation of MHC class II biosynthetic process GO:0045348 9.71 IL10 TLR4
48 positive regulation of interferon-beta biosynthetic process GO:0045359 9.71 TLR4 TLR9
49 negative regulation of cytokine secretion involved in immune response GO:0002740 9.71 IL10 TNF
50 negative regulation of interleukin-8 production GO:0032717 9.71 IL10 TLR9

Molecular functions related to Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 CXCL8 IL10 IL17A IL1A IL1B IL6
2 lipopolysaccharide receptor activity GO:0001875 9.16 TLR2 TLR4
3 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B TLR9

Sources for Periodontitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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