MCID: PRD008
MIFTS: 66

Periodontitis malady

Gastrointestinal diseases category

Summaries for Periodontitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Periodontitis /ˌpɛrioʊdɒnˈtaɪtɪs/ or pyorrhea /ˌpaɪəˈriə/ is a set of inflammatory diseases... more...

MalaCards: Periodontitis, also known as chronic periodontitis, is related to periodontal disease and aggressive periodontitis. An important gene associated with Periodontitis is ASPN (asporin), and among its related pathways are Immune System and TRAF Pathway. The drug carbamide peroxide and the compounds vegf and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, endothelial and heart, and related mouse phenotypes are immune system and homeostasis/metabolism.

Aliases & Classifications for Periodontitis

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8Disease Ontology, 10DISEASES, 60UMLS, 22GTR, 44Novoseek, 34MeSH, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

periodontitis 8 10 60
chronic periodontitis 8 22 44 60
chronic pericementitis 8


External Ids:

Disease Ontology8 DOID:824
MeSH34 D010518
NCIt39 C34918
ICD1025 K05.3

Related Diseases for Periodontitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Periodontitis family:

Periodontitis 1, Juvenile

Diseases related to Periodontitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 364)
idRelated DiseaseScoreTop Affiliating Genes
1periodontal disease31.9ELANE, MMP1, MMP8, IL6, IL1B, IL1A
2aggressive periodontitis31.7CTSC, JPD
3gingivitis31.7TNFSF11, ELANE, MMP1, MMP8, IL1B, IL1A
4diabetes mellitus31.0IL6, IL1B, CD14
5arthritis30.9TNFSF11, IL1A, IL1B, IL6
6rheumatoid arthritis30.9CD14, LTF, TNFRSF11B, TNFSF11, TLR4, IL1RN
7gingival overgrowth30.7MMP1, IL1B, IL1A
8atherosclerosis30.7TLR4, TNFRSF11B, CD14, IL1RN, IL1A, IL1B
9obesity30.6IL6
10root resorption30.5TNFRSF11B
11osteoporosis30.5MMP8, IL6, IL1RN, TNFRSF11B, TNFSF11
12vascular disease30.4ELANE, IL6, IL1B, IL1A, IL1RN
13neutropenia30.4IL1RN, ELANE
14coronary artery disease30.3IL6, CD14, TNFRSF11B, TNFSF11
15acute myocardial infarction30.2MMP8, CD14, TNFSF11
16myocardial infarction30.2CD14, POSTN
17bacterial vaginosis30.1IL1B, IL1A, LTF
18juvenile rheumatoid arthritis30.1IL1RN, IL1A, IL6
19systemic lupus erythematosus30.1TLR4, LTF, IL1RN, IL6
20psoriasis30.0LTF, IL1A, IL1B, IL6, ELANE
21familial mediterranean fever30.0IL1B
22connective tissue disease30.0IL6
23inflammatory bowel disease29.9TLR4, DEFB1, LTF, CD14, IL1RN, IL1B
24asthma29.9TLR4, DEFB1, POSTN, CD14, IL1B, MMP8
25tuberculosis29.9IL1B, TLR4
26crohn's disease29.9LTF
27papillon-lefevre disease29.9CTSC, JPD
28pneumonia29.6TLR4, DEFB1, IL1B, IL6, MMP8, ELANE
29breast cancer29.6TNFSF11, TNFRSF11B, POSTN, CD14, MMP8, MMP1
30sarcoidosis29.6IL1A, IL1RN, CD14, DEFB1, IL1B
31psoriatic arthritis29.6MMP1, IL1B, IL1A, TNFRSF11B, TNFSF11
32multiple sclerosis29.6IL1RN, IL1B, IL6, MMP8
33ankylosing spondylitis29.6TLR4, TNFSF11, TNFRSF11B, IL1RN
34vasculitis29.6ELANE, CD14, LTF
35pulmonary emphysema29.6ELANE, MMP1, MMP8
36glomerulonephritis29.6IL1RN, IL1B, ELANE
37thrombocytopenia29.6IL6, IL1A, TLR4
38liver cirrhosis29.6CD14
39peptic ulcer29.6CD14
40prostatitis29.6LTF
41chondrosarcoma29.6MMP1
42dementia29.6TNFRSF11B
43oral submucous fibrosis29.6MMP1
44alpha 1-antitrypsin deficiency29.6ELANE
45gingival disease10.7
46periodontosis10.6
47periapical periodontitis10.5
48chronic apical periodontitis10.5
49gingival recession10.5
50dental caries10.4

Graphical network of the top 20 diseases related to Periodontitis:



Diseases related to periodontitis

Clinical Features for Periodontitis

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Drugs & Therapeutics for Periodontitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Periodontitis

Drug clinical trials:

Search ClinicalTrials for Periodontitis

Search NIH Clinical Center for Periodontitis

Search CenterWatch for Periodontitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Periodontitis

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Sources:
22GTR
See all sources

Genetic tests related to Periodontitis:

id Genetic test Affiliating Genes
1 Periodontitis, Chronic22

Anatomical Context for Periodontitis

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32MalaCards
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MalaCards organs/tissues related to Periodontitis:

32
Bone, Endothelial, Heart, T cells, Monocytes, Kidney, Testes, Whole blood, B cells, Colon, Tongue, Prostate, Nk cells, Thyroid, Bone marrow, Liver, Placenta, Smooth muscle, Breast, Brain, Cortex

Animal Models for Periodontitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Periodontitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538712.5ELANE, TLR4, TNFSF11, TNFRSF11B, CTSC, DEFB1
2MP:000537612.1TNFSF11, CTSC, POSTN, LTF, CD14, IL1RN
3MP:000200611.1POSTN, IL1B, IL6, MMP8, ELANE
4MP:000539011.0TNFSF11, TNFRSF11B, POSTN, CD14, IL1B, IL6

Publications for Periodontitis

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Sources:
50PubMed
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Articles related to Periodontitis:

(show top 50)    (show all 3375)
idTitleAuthorsYear
1
Effect of scaling and root planing combined with systemic doxycycline therapy on glycemic control in diabetes mellitus subjects with chronic generalized periodontitis: a clinical study. (23678391)
2013
2
Aspirin intake: Can be a confounding factor in clinical trial for periodontal disease. (24302845)
2013
3
Association between periodontal disease and venous thromboembolic disease. (23757458)
2013
4
Oral and maxillofacial pathology case of the month. Cemental tear and chronic periodontitis. (24195195)
2013
5
Effect of smoking on neutrophil apoptosis in chronic periodontitis: an immunohistochemical study. (23852253)
2013
6
Periodontal disease and rheumatoid arthritis: a systematic review. (23525531)
2013
7
The effect of orally administered epigallocatechin-3-gallate on ligature-induced periodontitis in rats. (23581513)
2013
8
Lipid Profile Parameters under influence of Periodontitis Associated with Chronic Stress: An Animal Model Study. (24155613)
2013
9
Atorvastatin decreases bone loss, inflammation and oxidative stress in experimental periodontitis. (24130702)
2013
10
Effects of periodontitis. (24080923)
2013
11
Oral Health Knowledge of Periodontal Disease among University Students. (23573091)
2013
12
Direct recognition of Fusobacterium nucleatum by the NK cell natural cytotoxicity receptor NKp46 aggravates periodontal disease. (22457623)
2012
13
Relationship between Gram negative enteric rods, Aggregatibacter actinomycetemcomitans, and clinical parameters in periodontal disease. (22628966)
2012
14
Analysis of osteoprotegerin (OPG) gene polymorphism in Iranian patients with chronic periodontitis and peri-implantitis. A cross-sectional study. (23304691)
2012
15
Role of smoking in periodontal disease among diabetic patients. (22808575)
2012
16
Periodontal disease: a genetic perspective. (23318742)
2012
17
IL-1-polymorphism and severity of periodontal disease. (21449691)
2012
18
Serum lipids modify periodontal infection - C-reactive protein association. (22780440)
2012
19
Interleukin-8 gene promoter polymorphism (rs4073) may contribute to chronic periodontitis. (21091348)
2011
20
Awareness regarding the systemic effects of periodontal disease among medical interns in India. (21731297)
2011
21
Salivary IL-6 levels in oral leukoplakia with dysplasia and its clinical relevance to tobacco habits and periodontitis. (20563615)
2011
22
Receptor activator of nuclear factor kappa B ligand and osteoprotegerin expression in chronic apical periodontitis: possible association with inflammatory cells. (21933620)
2011
23
Response of chronic and aggressive periodontitis to treatment. (20403111)
2010
24
IL-1 gene cluster is not linked to aggressive periodontitis. (20335539)
2010
25
Management of infrabony defects in mandibular molars in a patient with generalized aggressive periodontitis using autogenous bone graft from maxillary tuberosity. (20922081)
2010
26
Involvement of MT1-MMP and TIMP-2 in human periodontal disease. (20233321)
2010
27
Ceruloplasmin induces polymorphonuclear leukocyte priming in localized aggressive periodontitis. (19656030)
2009
28
Correspondences of hydrostatic pressure in periodontal ligament with regions of root resorption: a clinical and a finite element study of the same human teeth. (18951647)
2009
29
Matrix metalloproteinases, tissue inhibitor of matrix metalloproteinase-1, and laminin-5 gamma2 chain immunolocalization in gingival tissue of endotoxin-induced periodontitis in rats: effects of low-dose doxycycline and alendronate. (17199549)
2007
30
Chronic periodontitis and the risk of tongue cancer. (17515503)
2007
31
Use of microarrays to find novel regulators of periodontal ligament fibroblast differentiation. (17024420)
2007
32
Cleaved inflammatory lactoferrin peptides in parotid saliva of periodontitis patients. (17030385)
2007
33
Gingival tissue and crevicular fluid co-operation in adult periodontitis. (16373682)
2006
34
Evaluation of RANK/RANKL/OPG gene polymorphisms in aggressive periodontitis. (16953816)
2006
35
The associations between gingival crevice fluid matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 and periodontitis in human immunodeficiency virus-positive patients. (17076772)
2006
36
Demonstration of factor H-like protein 1 binding to Treponema denticola, a pathogen associated with periodontal disease in humans. (16239506)
2005
37
periostin null mice exhibit dwarfism, incisor enamel defects, and an early-onset periodontal disease-like phenotype. (16314533)
2005
38
Clinical and radiographic evaluation of Emdogain as a regenerative material in the treatment of interproximal vertical defects in chronic and aggressive periodontitis patients. (15119889)
2004
39
The short-term effects of treatment of chronic periodontitis on circulating levels of endotoxin, C-reactive protein, tumor necrosis factor-alpha, and interleukin-6. (15088881)
2004
40
Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells. (15516325)
2004
41
Antibiotic resistance in bacteria isolated from subgingival plaque in a norwegian population with refractory marginal periodontitis. (12654689)
2003
42
A role for decorin in the structural organization of periodontal ligament. (11140699)
2000
43
Identification of MRP-8 (calgranulin A) as a major responsive protein in chronic periodontitis. (11113873)
2000
44
Effects of bisphosphonate on matrix metalloproteinase enzymes in human periodontal ligament cells. (10960024)
2000
45
A cross-sectional study into the prevalence of root caries in periodontal maintenance patients. (9923507)
1999
46
Effectiveness of periodontal therapy in patients with drug-induced gingival overgrowth. Long-term results. (10505798)
1999
47
Periodontal and prosthodontic treatment of amelogenesis imperfecta: a clinical report. (8366451)
1993
48
Adenylate cyclase and guanylate cyclase in the saliva of healthy persons and in periodontitis]. (1685812)
1991
49
Bone-resorbing activity and prostaglandin E produced by human periodontal ligament cells in vitro. (2127873)
1990
50
Treatment of localized juvenile periodontitis (periodontosis). A review. (3543283)
1987

Genetic Variations for Periodontitis

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Expression for genes affiliated with Periodontitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Periodontitis

Search GEO for disease gene expression data for Periodontitis.

Pathways for genes affiliated with Periodontitis

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Sources:
53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 52R&D Systems, 59Tocris Bioscience, 4Cell Signaling Technology
See all sources

Pathways related to Periodontitis according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.6TLR4, CTSC, DEFB1, CD14, IL1RN, IL1A
2
Hide members
11.3TLR4, TNFSF11, TNFRSF11B, CD14, IL1A, IL1B
3
Immune response Bacterial infections in normal airways
Hide members
11.3IL6, IL1B, IL1A, IL1RN, CD14, TLR4
4
Hide members
11.2TLR4, TNFSF11, TNFRSF11B, CD14, IL1A
511.2TLR4, CD14, IL1A, IL1B, IL6
6
Hide members
11.2IL6, IL1B, IL1A, CD14, TLR4
711.2TLR4, CD14, IL1A, IL1B, IL6
811.2IL6, IL1B, IL1A, CD14, TLR4
911.2TLR4, CD14, IL1A, IL1B, IL6
1011.1TNFSF11, TNFRSF11B, IL1A, IL1B
1111.1TLR4, TNFSF11, CD14, IL1B
1211.1IL6, IL1B, IL1A, CD14
13
Hide members
11.1IL6, IL1B, IL1A, IL1RN
1411.1IL6, IL1B, IL1A, IL1RN
15
Hide members
11.1IL1RN, IL1A, IL1B, IL6
16
Hide members
11.1IL6, IL1B, IL1A, TLR4
17
Hide members
11.1TLR4, IL1A, IL1B, IL6
1811.1TLR4, IL1A, IL1B, IL6
19
Hide members
11.0IL6, IL1B, CD14, TLR4
2011.0TLR4, CD14, IL1B, IL6
2111.0TLR4, CD14, IL1B, IL6
22
Hide members
11.0TLR4, CD14, IL1B, IL6
23
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.9TNFSF11, TNFRSF11B, IL1A
2410.9ELANE, MMP8, LTF
25
Hide members
10.9IL1B, IL1A, IL1RN
26
Hide members
10.9IL1B, IL1A, TLR4
2710.9IL1B, TNFSF11, TLR4
2810.9IL1A, IL1B, IL6
2910.9IL6, IL1B, TNFSF11
3010.9TLR4, CD14, IL1A
31
Hide members
10.9TLR4, IL1B, IL6
32
Hide members
10.9TLR4, IL1B, IL6
3310.9IL6, CD14, TLR4
34
Cytokine production by Th17 cells in CF (Mouse model)
10.9TLR4, CD14, IL6
3510.8TNFRSF11B, TNFSF11
3610.8IL1A, IL1B
3710.8TNFSF11, TLR4
3810.8IL1B, IL6
3910.8TLR4, CD14
4010.6IL1A
4110.6TLR4

Compounds for genes affiliated with Periodontitis

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Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 2BitterDB, 49PharmGKB
See all sources

Compounds related to Periodontitis according to GeneCards/GeneDecks:

(show top 50)    (show all 153)
idCompoundScoreTop Affiliating Genes
1vegf4412.6IL1RN, TNFRSF11B, TNFSF11, POSTN, MMP1, MMP8
2retinoic acid44 2413.6IL6, MMP8, MMP1, IL1A, IL1RN, CD14
3polymyxin b4412.4LTF, DEFB1, TNFRSF11B, TNFSF11, TLR4, CD14
4cysteine4412.2MMP8, TNFRSF11B, CTSC, LTF, CD14, TNFSF11
5calcitriol44 59 11 2415.0TNFSF11, IL1A, CD14, IL1B, IL6, MMP1
6sb 20358044 5913.0TNFRSF11B, IL1A, TNFSF11, IL1B, TLR4, IL6
7fibrinogen4412.0TLR4, TNFRSF11B, CD14, IL6, LTF, IL1RN
8genistein44 28 59 2 11 2417.0TNFSF11, TNFRSF11B, IL1A, IL1B, IL6, MMP8
9cyclosporin a44 28 5913.9TNFRSF11B, TNFSF11, MMP1, LTF, ELANE, MMP8
10infliximab44 49 1113.9IL6, TNFSF11, TNFRSF11B, IL1RN, IL1B, MMP1
11neopterin4411.9LTF, ELANE, IL6, IL1B, IL1A, CD14
12dexamethasone44 49 28 1114.9DEFB1, IL6, CD14, LTF, TLR4, TNFSF11
13heparin44 28 11 2414.9IL1A, CTSC, LTF, CD14, ELANE, TNFRSF11B
14serine4411.9TNFRSF11B, TNFSF11, TLR4, IL1RN, IL1A, MMP8
15hyaluronic acid44 2412.9ELANE, IL6, IL1B, IL1A, MMP1, IL1RN
16fmlp4411.9IL1RN, CD14, LTF, TLR4, IL1B, ELANE
17prostaglandin4411.9IL1RN, IL1A, MMP1, IL1B, TNFRSF11B, TNFSF11
18clodronate44 49 1113.8IL1B, MMP8, MMP1, TNFSF11, TNFRSF11B, IL6
19creatinine4411.8TNFRSF11B, CD14, IL1A, TNFSF11, MMP1, LTF
20ns 39844 5912.8TNFSF11, TNFRSF11B, IL1RN, IL1A, MMP1, IL1B
21etanercept44 49 1113.7MMP1, IL1RN, TNFSF11, TNFRSF11B, IL6, IL1B
22peptidoglycan44 2812.7IL1RN, TNFSF11, TLR4, IL1B, IL6, CD14
23vitamin d4411.7IL6, TLR4, TNFSF11, TNFRSF11B, CD14, ELANE
24leukotriene b444 59 2413.7IL1RN, ELANE, IL6, IL1B, IL1A, LTF
25histamine44 28 2413.7LTF, IL1RN, CD14, IL1B, CTSC, TLR4
26pentoxifylline44 1112.6ELANE, MMP1, CD14, IL1RN, LTF
27rantes4411.6IL6, IL1B, IL1A, CD14, TLR4
28tgf beta14411.6MMP1, IL6, IL1RN, TNFRSF11B, TLR4, IL1B
29zymosan4411.6TLR4, ELANE, IL1RN, CD14, LTF
30leflunomide49 44 1113.6MMP1, IL6, IL1B, IL1RN, TNFSF11
31lipoteichoic acid4411.5CD14, IL1RN, IL6, TLR4, IL1B
32il 104411.5IL6, IL1RN, IL1A, IL1B, TLR4
33hydrocortisone44 2 59 1114.5TNFRSF11B, LTF, MMP1, ELANE
34anakinra44 1112.4IL6, IL1B, IL1RN, TNFRSF11B
35doxycycline44 1112.4MMP1, MMP8, LTF, TNFSF11, ELANE
36superoxide44 2412.4MMP8, ELANE, IL1B, LTF
37hbd24411.4IL6, TLR4, DEFB1, IL1B
38ibuprofen44 28 49 11 2415.3IL6, IL1RN, MMP1, LTF, IL1B
39gold sodium thiomalate4411.3IL1RN, IL1B, IL1A, CD14
40pamidronate44 49 1113.3TNFSF11, TNFRSF11B, IL6, MMP1
41pdtc4411.3IL6, IL1B, IL1A, TLR4, MMP1
42tenidap44 2812.2IL1A, LTF
43norepinephrine44 11 2413.1MMP1, LTF, ELANE
44h2o24411.1IL1RN, LTF, MMP8, MMP1
45ciprofloxacin44 1112.1LTF, DEFB1, IL1A, MMP1
46endotoxin4411.1LTF
47indomethacin44 59 28 1114.0LTF
48gm-csf44 2812.0CD14
49pmma4411.0TNFSF11, TNFRSF11B, LTF, IL6
50aprotinin44 1111.6MMP1, LTF, ELANE

GO Terms for genes affiliated with Periodontitis

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Sources:
16Gene Ontology
See all sources

Cellular components related to Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557612.1ELANE, TNFSF11, TNFRSF11B, DEFB1, LTF, CD14
2extracellular spaceGO:00561511.5TNFSF11, TNFRSF11B, CD14, IL1RN, IL1A, IL1B
3secretory granuleGO:03014110.9ELANE, IL1B, LTF
4proteinaceous extracellular matrixGO:00557810.9TNFRSF11B, POSTN, MMP8, MMP1, ASPN

Biological processes related to Periodontitis according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.8IL1B, IL1A, IL1RN, DEFB1, CTSC, TNFSF11
2positive regulation of NF-kappaB transcription factor activityGO:05109211.5TLR4, TNFSF11, LTF, IL1B, IL6
3extracellular matrix organizationGO:03019811.5TNFRSF11B, POSTN, MMP8, MMP1, ELANE
4proteolysisGO:00650811.3CTSC, LTF, MMP8, MMP1, ELANE
5positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312311.3IL1B, LTF, TNFSF11, TLR4
6cytokine-mediated signaling pathwayGO:01922111.2IL6, IL1B, IL1A, TNFSF11
7positive regulation of nitric oxide biosynthetic processGO:04542911.2IL6, IL1B, TLR4
8positive regulation of interleukin-6 productionGO:03275511.2IL6, IL1B, TLR4
9positive regulation of JNK cascadeGO:04633011.1TLR4, TNFSF11, IL1B
10fever generationGO:00166011.1IL1B, IL1A
11inflammatory responseGO:00695411.1IL6, IL1B, IL1A, CD14
12negative regulation of chemokine biosynthetic processGO:04507911.0IL6, ELANE
13collagen catabolic processGO:03057411.0MMP8, MMP1, ELANE
14cellular response to lipoteichoic acidGO:07122311.0CD14, TLR4
15positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.9IL6, IL1B, TNFSF11
16positive regulation of interleukin-8 biosynthetic processGO:04541610.9ELANE, TLR4
17extracellular matrix disassemblyGO:02261710.8MMP8, MMP1, ELANE
18positive regulation of interleukin-2 biosynthetic processGO:04508610.5IL1B, IL1A

Molecular functions related to Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512511.1IL6, IL1B, IL1A, TNFRSF11B, TNFSF11
2serine-type endopeptidase activityGO:00425211.1ELANE, MMP8, LTF, CTSC
3interleukin-1 receptor bindingGO:00514910.6IL1RN, IL1A, IL1B

Products for genes affiliated with Periodontitis

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  • Antibodies
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Sources for Periodontitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet