MCID: PRD008
MIFTS: 58

Periodontitis malady

Gastrointestinal category

Summaries for Periodontitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Periodontitis /ˌpɛrioʊdɒnˈtaɪtɪs/ or pyorrhea /ˌpaɪəˈriə/ is a set of inflammatory diseases... more...

MalaCards: Periodontitis, also known as chronic periodontitis, is related to aggressive periodontitis and arthritis. An important gene associated with Periodontitis is ASPN (asporin), and among its related pathways are Immune System and TRAF Pathway. The drug carbamide peroxide and the compounds vegf and retinoic acid have been mentioned in the context of this disorder. Related mouse phenotypes are immune system and homeostasis/metabolism.

Aliases & Classifications for Periodontitis

Sources:
8Disease Ontology, 22GTR, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

periodontitis 8 10 61
chronic periodontitis 8 22 45 61
chronic pericementitis 8


External Ids:

Disease Ontology8 DOID:824
MeSH35 D010518
NCIt40 C34918
ICD1025 K05.3

Related Diseases for Periodontitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Periodontitis family:

periodontitis 1, juvenile

Diseases related to Periodontitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 357)
idRelated DiseaseScoreTop Affiliating Genes
1aggressive periodontitis31.7CTSC, JPD
2arthritis30.9IL6, IL1A, IL1B, TNFSF11
3atherosclerosis30.7CD14, ELANE, IL1B, TNFRSF11B, IL1RN, IL1A
4coronary heart disease30.6IL6, TLR4, MMP8
5root resorption30.6TNFRSF11B
6osteoporosis30.5MMP8, IL6, IL1RN, TNFRSF11B, TNFSF11
7vascular disease30.4IL1RN, IL1A, IL1B, IL6, ELANE
8coronary artery disease,30.4IL6, CD14, TNFRSF11B, TNFSF11
9acute myocardial infarction30.3TNFSF11, CD14, MMP8
10pulmonary disease, chronic obstructive30.2DEFB1, MMP1, ELANE, IL6, MMP8
11bacterial vaginosis30.1LTF, IL1B, IL1A
12juvenile rheumatoid arthritis30.1IL1RN, IL1A, IL6
13systemic lupus erythematosus30.1LTF, TLR4, IL6, IL1RN
14familial mediterranean fever30.0IL1B
15pemphigus vulgaris30.0IL1A
16asthma29.9DEFB1, ELANE, MMP8, IL1B, CD14, TLR4
17osteoporosis, postmenopausal29.9TNFSF11, TNFRSF11B, IL1RN
18tuberculosis29.9TLR4, IL1B
19haim-munk syndrome29.9CTSC, JPD
20papillon-lefevre disease29.9CTSC, JPD
21septic shock29.7ELANE, IL6, TLR4, LTF, CD14, IL1RN
22psoriatic arthritis29.7MMP1, IL1A, TNFSF11, TNFRSF11B, IL1B
23ankylosing spondylitis29.7TNFSF11, TLR4, TNFRSF11B, IL1RN
24vasculitis29.7ELANE, CD14, LTF
25thrombocytopenia29.7IL1A, TLR4, IL6
26rheumatic disease29.7TNFSF11, TNFRSF11B, IL1RN
27hypercholesterolemia29.7CD14
28oral submucous fibrosis29.7MMP1
29oral cancer29.7MMP1
30periodontosis10.6
31chronic apical periodontitis10.5
32gingival recession10.5
33acute apical periodontitis10.4
34tooth disease10.4
35dent's disease10.4
36root caries10.4
37necrotizing ulcerative gingivitis10.3
38pulpitis10.3
39lip disease10.3
40lichen planus10.2
41hypophosphatasia10.2
42sturge-weber syndrome10.2
43weber syndrome10.2
44oral lichen planus10.2
45hypotrichosis-osteolysis-periodontitis-palmoplantar keratoderma syndrome10.2
46tooth resorption10.2
47fibromatosis10.2
48hypoxia10.2
49periodontitis 1, juvenile10.2
50marfan syndrome10.2

Graphical network of the top 20 diseases related to Periodontitis:



Diseases related to periodontitis

Clinical Features for Periodontitis

Drugs & Therapeutics for Periodontitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Periodontitis

Drug clinical trials:

Search ClinicalTrials for Periodontitis

Search NIH Clinical Center for Periodontitis

Search CenterWatch for Periodontitis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Periodontitis

Sources:
22GTR
See all sources

Genetic tests related to Periodontitis:

id Genetic test Affiliating Genes
1 Periodontitis, Chronic22

Anatomical Context for Periodontitis

Animal Models for Periodontitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Periodontitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538712.5TNFSF11, CTSC, DEFB1, POSTN, LTF, CD14
2MP:000537612.1CD14, ELANE, IL6, IL1B, IL1A, TLR4
3MP:000200611.1ELANE, MMP8, IL6, IL1B, POSTN
4MP:000539011.0TNFSF11, IL1B, CD14, POSTN, TNFRSF11B, IL6

Publications for Periodontitis

Sources:
51PubMed
See all sources

Articles related to Periodontitis:

(show top 50)    (show all 1703)
idTitleAuthorsYear
1
Antibiotic resistance in human chronic periodontitis microbiota. (23688097)
2014
2
Effect of Non-surgical Periodontal Therapy on Serum Levels of TNF-a, IL-6 and C-reactive Protein in Periodontitis Subjects with Stable Coronary Heart Disease. (24436950)
2013
3
Quercetin Inhibits Inflammatory Bone Resorption in a Mouse Periodontitis Model. (24246038)
2013
4
The Role of Interleukin-1 Genotype in the Association between Coronary Heart Disease and Periodontitis in a Syrian Population. (23691333)
2013
5
Effect of Chronic Periodontitis on Serum and Gingival Crevicular Fluid Oxidant and AntioXidant Status in Patients With Familial Mediterranean Fever Before and After Periodontal Treatment. (23826647)
2013
6
Treatment of periodontitis as a manifestation of neutropenia with or without systemic antibiotics: a systematic review. (23635971)
2013
7
Expression levels of th-2 and th-17 characteristic genes in healthy tissue versus periodontitis. (23724200)
2013
8
Saliva, Serum Levels of Pentraxin-3 and Interleukin-1beta in Generalised Aggressive or Chronic Periodontitis. (23952075)
2013
9
Periodontal treatment decreases levels of antibodies to Porphyromonas gingivalis and citrulline in patients with rheumatoid arthritis and periodontitis. (23701010)
2013
10
Modeling susceptibility to periodontitis. (23100272)
2013
11
Alloxan-induced hyperglycemia causes rapid-onset and progressive dental caries and periodontitis in F344 rats. (22936448)
2012
12
Association of generalized aggressive periodontitis and ectrodactyly-ectodermal dysplasia-cleft syndrome. (23162310)
2012
13
Effectiveness of a controlled release chlorhexidine chip (PerioCola8c-CG) as an adjunctive to scaling and root planing when compared to scaling and root planing alone in the treatment of chronic periodontitis: A comparative study. (23493496)
2012
14
Profile of chronic and aggressive periodontitis among Senegalese. (22324005)
2011
15
Salivary MMP-8, TIMP-1, and ICTP as markers of advanced periodontitis. (20507371)
2010
16
Immunologic and microbiologic profiles of chronic and aggressive periodontitis subjects. (20450404)
2010
17
Ossifying fibroma misdiagnosed as chronic apical periodontitis. (20171381)
2010
18
DNA methylation status of the IL8 gene promoter in aggressive periodontitis. (20450371)
2010
19
Immunological differences and similarities between chronic periodontitis and aggressive periodontitis. (20403108)
2010
20
Genetic and environmental risk factors for chronic periodontitis and aggressive periodontitis. (20403110)
2010
21
Digital subtraction radiography evaluation of the bone repair process of chronic apical periodontitis after root canal treatment. (20491984)
2010
22
Effect of an aldose reductase inhibitor on alveolar bone loss associated with periodontitis in diabetic rats. (20463423)
2010
23
Relationship of neutrophil phagocytosis and oxidative burst with the subgingival microbiota of generalized aggressive periodontitis. (19239639)
2009
24
Interleukin-10 (-592 C/A) and interleukin-12B (+16974 A/C) gene polymorphisms and the interleukin-10 ATA haplotype are associated with periodontitis in a Taiwanese population. (19210338)
2009
25
Interleukin-6 polymorphisms modify the risk of periodontitis: a systematic review and meta-analysis. (19946956)
2009
26
Markers of bone destruction and formation and periodontitis in type 1 diabetes mellitus. (19624408)
2009
27
Interleukin-1 and tumor necrosis factor-alpha gene polymorphisms in Turkish patients with localized aggressive periodontitis. (18587204)
2008
28
Effect of MMP-1 promoter polymorphisms on GCF MMP-1 levels and outcome of periodontal therapy in patients with severe chronic periodontitis. (18710412)
2008
29
Lymphotoxin alpha LTA+496C allele is a risk factor for periodontitis in patients with coronary artery disease. (18384488)
2008
30
Effect of smoking on serum RANKL and OPG in sex, age and clinically matched supportive-therapy periodontitis patients. (17378883)
2007
31
Demographic, clinical, and microbial aspects of chronic and aggressive periodontitis in Colombia: a multicenter study. (17397309)
2007
32
Detection and significance of IL-1beta and MMP-8 in patients with periodontitis of whole unstimulated saliva]. (17546376)
2007
33
RANKL inhibition through osteoprotegerin blocks bone loss in experimental periodontitis. (17608585)
2007
34
Effects of surgical periodontal therapy on serum levels of TNF-alpha in patients with chronic periodontitis. (18018468)
2007
35
Influence of periodontal therapy on the regulation of soluble cell adhesion molecule expression in aggressive periodontitis patients. (17397316)
2007
36
Early colonization of non-submerged dental implants in patients with a history of advanced aggressive periodontitis. (16441780)
2006
37
Assessment of salivary levels of the chosen exoglycosidases in patients with aggressive periodontitis after treatment with doxycycline. (17458082)
2006
38
Cytokine profiles in peripheral blood and whole blood cell cultures associated with aggressive periodontitis, juvenile idiopathic arthritis, and rheumatoid arthritis. (16332240)
2005
39
Do interleukin-1 polymorphisms predict the development of periodontitis or the success of dental implants? (11858158)
2002
40
Gender differences in HLA phenotype frequencies found in German patients with generalized aggressive periodontitis and chronic periodontitis. (12485327)
2002
41
The relationship between tumor necrosis factor A-308 gene polymorphism and susceptibility of severe periodontitis in adults]. (12475426)
2002
42
The levels of interleukin 8 in gingival crevicular fluids of chronic periodontitis]. (14993968)
2001
43
Beta-lactamase producing bacteria in the subgingival microflora of adult patients with periodontitis. A comparison between Spain and The Netherlands. (10914894)
2000
44
The association of calprotectin level in gingival crevicular fluid with gingival index and the activities of collagenase and aspartate aminotransferase in adult periodontitis patients. (10776922)
2000
45
Can the location of tooth agenesis and the location of initial bone loss seen in juvenile periodontitis be explained by neural developmental fields in the jaws? (9083580)
1997
46
Assessment of in vitro interleukin-2-producing capacity of peripheral blood lymphocytes from patients with periodontitis. (9049797)
1997
47
The relationship between gingival crevicular fluid cathepsin B activity and periodontal attachment loss in chronic periodontitis patients: a 2-year longitudinal study. (8884632)
1996
48
Immunohistochemical study of neutrophil- and fibroblast-type collagenases and stromelysin-1 in adult periodontitis. (7871357)
1994
49
Paresthesia of the mental nerve after an acute exacerbation of chronic apical periodontitis. (6945343)
1981
50
Comparative enzymatic histochemical investigations of gingival papillae in early parodontosis (periodontosis) and parodontitis (periodontitis) traumatica. (5271943)
1970

Genetic Variations for Periodontitis

Expression for genes affiliated with Periodontitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Periodontitis

Search GEO for disease gene expression data for Periodontitis.

Pathways for genes affiliated with Periodontitis

Sources:
54Reactome, 52QIAGEN, 38NCBI BioSystems Database, 30KEGG, 12EMD Millipore, 53R&D Systems, 60Tocris Bioscience, 4Cell Signaling Technology
See all sources

Pathways related to Periodontitis according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.6IL6, IL1B, IL1A, CD14, DEFB1, CTSC
2
Hide members
11.3TNFRSF11B, IL1B, TLR4, CD14, IL1A, TNFSF11
3
Immune response Bacterial infections in normal airways
Hide members
11.3TLR4, IL6, IL1B, IL1A, IL1RN, CD14
4
Hide members
11.2TLR4, TNFRSF11B, TNFSF11, IL1A, CD14
511.2IL6, CD14, IL1A, IL1B, TLR4
6
Hide members
11.2TLR4, IL1A, IL6, IL1B, CD14
711.2CD14, IL1A, IL6, IL1B, TLR4
811.2IL6, IL1B, IL1A, CD14, TLR4
911.2TLR4, IL6, IL1B, IL1A, CD14
1011.1IL1B, IL1A, TNFSF11, TNFRSF11B
1111.1TLR4, IL1B, TNFSF11, CD14
1211.1CD14, IL1B, IL6, IL1A
13
Hide members
11.1IL6, IL1B, IL1A, IL1RN
1411.1IL6, IL1RN, IL1A, IL1B
15
Hide members
11.1IL6, IL1B, IL1A, IL1RN
16
Hide members
11.1IL1B, IL1A, IL6, TLR4
17
Hide members
11.1TLR4, IL1A, IL1B, IL6
1811.1IL6, IL1A, TLR4, IL1B
19
Hide members
11.0IL6, IL1B, TLR4, CD14
2011.0IL6, IL1B, CD14, TLR4
2111.0IL6, IL1B, CD14, TLR4
22
Hide members
11.0TLR4, IL6, IL1B, CD14
23
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.9IL1A, TNFSF11, TNFRSF11B
2410.9ELANE, LTF, MMP8
25
Hide members
10.9IL1RN, IL1A, IL1B
26
Hide members
10.9TLR4, IL1A, IL1B
2710.9IL1B, TNFSF11, TLR4
2810.9IL6, IL1B, IL1A
2910.9IL6, TNFSF11, IL1B
3010.9TLR4, CD14, IL1A
31
Hide members
10.9IL1B, IL6, TLR4
32
Hide members
10.9IL6, TLR4, IL1B
3310.9CD14, IL6, TLR4
34
Cytokine production by Th17 cells in CF (Mouse model)
10.9IL6, CD14, TLR4
3510.8TNFRSF11B, TNFSF11
3610.8IL1B, IL1A
3710.8TNFSF11, TLR4
3810.8IL6, IL1B
3910.8CD14, TLR4
4010.6IL1A
4110.6TLR4

Compounds for genes affiliated with Periodontitis

Sources:
45Novoseek, 24HMDB, 60Tocris Bioscience, 11DrugBank, 29IUPHAR, 2BitterDB, 50PharmGKB
See all sources

Compounds related to Periodontitis according to GeneCards/GeneDecks:

(show top 50)    (show all 153)
idCompoundScoreTop Affiliating Genes
1vegf4512.6IL1RN, TNFRSF11B, TNFSF11, POSTN, MMP1, MMP8
2retinoic acid45 2413.6IL6, MMP8, MMP1, IL1A, IL1RN, CD14
3polymyxin b4512.4LTF, DEFB1, TNFRSF11B, TNFSF11, TLR4, CD14
4cysteine4512.2MMP8, TNFRSF11B, CTSC, LTF, CD14, TNFSF11
5calcitriol45 60 11 2415.0TNFSF11, IL1A, CD14, IL1B, IL6, MMP1
6sb 20358045 6013.0TNFRSF11B, IL1A, TNFSF11, IL1B, TLR4, IL6
7fibrinogen4512.0TLR4, TNFRSF11B, CD14, IL6, LTF, IL1RN
8genistein45 29 60 2 11 2417.0TNFSF11, TNFRSF11B, IL1A, IL1B, IL6, MMP8
9cyclosporin a45 29 6013.9TNFRSF11B, TNFSF11, MMP1, LTF, ELANE, MMP8
10infliximab45 50 1113.9IL6, TNFSF11, TNFRSF11B, IL1RN, IL1B, MMP1
11neopterin4511.9LTF, ELANE, IL6, IL1B, IL1A, CD14
12dexamethasone45 50 29 1114.9DEFB1, IL6, CD14, LTF, TLR4, TNFSF11
13heparin45 29 11 2414.9IL1A, CTSC, LTF, CD14, ELANE, TNFRSF11B
14serine4511.9TNFRSF11B, TNFSF11, TLR4, IL1RN, IL1A, MMP8
15hyaluronic acid45 2412.9ELANE, IL6, IL1B, IL1A, MMP1, IL1RN
16fmlp4511.9IL1RN, CD14, LTF, TLR4, IL1B, ELANE
17prostaglandin4511.9IL1RN, IL1A, MMP1, IL1B, TNFRSF11B, TNFSF11
18clodronate45 50 1113.8IL1B, MMP8, MMP1, TNFSF11, TNFRSF11B, IL6
19creatinine4511.8TNFRSF11B, CD14, IL1A, TNFSF11, MMP1, LTF
20ns 39845 6012.8TNFSF11, TNFRSF11B, IL1RN, IL1A, MMP1, IL1B
21etanercept45 50 1113.7MMP1, IL1RN, TNFSF11, TNFRSF11B, IL6, IL1B
22peptidoglycan45 2912.7IL1RN, TNFSF11, TLR4, IL1B, IL6, CD14
23vitamin d4511.7IL6, TLR4, TNFSF11, TNFRSF11B, CD14, ELANE
24leukotriene b445 60 2413.7IL1RN, ELANE, IL6, IL1B, IL1A, LTF
25histamine45 29 2413.7LTF, IL1RN, CD14, IL1B, CTSC, TLR4
26pentoxifylline45 1112.6ELANE, MMP1, CD14, IL1RN, LTF
27rantes4511.6IL6, IL1B, IL1A, CD14, TLR4
28tgf beta14511.6MMP1, IL6, IL1RN, TNFRSF11B, TLR4, IL1B
29zymosan4511.6TLR4, ELANE, IL1RN, CD14, LTF
30leflunomide50 45 1113.6MMP1, IL6, IL1B, IL1RN, TNFSF11
31lipoteichoic acid4511.5CD14, IL1RN, IL6, TLR4, IL1B
32il 104511.5IL6, IL1RN, IL1A, IL1B, TLR4
33hydrocortisone45 2 60 1114.5TNFRSF11B, LTF, MMP1, ELANE
34anakinra45 1112.4IL6, IL1B, IL1RN, TNFRSF11B
35doxycycline45 1112.4MMP1, MMP8, LTF, TNFSF11, ELANE
36superoxide45 2412.4MMP8, ELANE, IL1B, LTF
37hbd24511.4IL6, TLR4, DEFB1, IL1B
38ibuprofen45 29 50 11 2415.3IL6, IL1RN, MMP1, LTF, IL1B
39gold sodium thiomalate4511.3IL1RN, IL1B, IL1A, CD14
40pamidronate45 50 1113.3TNFSF11, TNFRSF11B, IL6, MMP1
41pdtc4511.3IL6, IL1B, IL1A, TLR4, MMP1
42tenidap45 2912.2IL1A, LTF
43norepinephrine45 11 2413.1MMP1, LTF, ELANE
44h2o24511.1IL1RN, LTF, MMP8, MMP1
45ciprofloxacin45 1112.1LTF, DEFB1, IL1A, MMP1
46endotoxin4511.1LTF
47indomethacin45 60 29 1114.0LTF
48gm-csf45 2912.0CD14
49pmma4511.0TNFSF11, TNFRSF11B, LTF, IL6
50aprotinin45 1111.6MMP1, LTF, ELANE

GO Terms for genes affiliated with Periodontitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557612.1ELANE, TNFSF11, TNFRSF11B, DEFB1, LTF, CD14
2extracellular spaceGO:00561511.5IL6, MMP8, IL1A, IL1RN, CD14, TNFRSF11B
3secretory granuleGO:03014110.9ELANE, IL1B, LTF
4proteinaceous extracellular matrixGO:00557810.9TNFRSF11B, POSTN, MMP8, MMP1, ASPN

Biological processes related to Periodontitis according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.8IL1B, IL1A, IL1RN, DEFB1, CTSC, TNFSF11
2positive regulation of NF-kappaB transcription factor activityGO:05109211.5TLR4, TNFSF11, LTF, IL1B, IL6
3extracellular matrix organizationGO:03019811.5TNFRSF11B, POSTN, MMP8, MMP1, ELANE
4proteolysisGO:00650811.3CTSC, LTF, MMP8, MMP1, ELANE
5positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312311.3IL1B, LTF, TNFSF11, TLR4
6cytokine-mediated signaling pathwayGO:01922111.2IL6, IL1B, IL1A, TNFSF11
7positive regulation of nitric oxide biosynthetic processGO:04542911.2IL6, IL1B, TLR4
8positive regulation of interleukin-6 productionGO:03275511.2IL6, IL1B, TLR4
9positive regulation of JNK cascadeGO:04633011.1TLR4, TNFSF11, IL1B
10fever generationGO:00166011.1IL1B, IL1A
11inflammatory responseGO:00695411.1IL6, IL1B, IL1A, CD14
12negative regulation of chemokine biosynthetic processGO:04507911.0IL6, ELANE
13collagen catabolic processGO:03057411.0MMP8, MMP1, ELANE
14cellular response to lipoteichoic acidGO:07122311.0CD14, TLR4
15positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.9IL6, IL1B, TNFSF11
16positive regulation of interleukin-8 biosynthetic processGO:04541610.9ELANE, TLR4
17extracellular matrix disassemblyGO:02261710.8MMP8, MMP1, ELANE
18positive regulation of interleukin-2 biosynthetic processGO:04508610.5IL1B, IL1A

Molecular functions related to Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512511.1IL1A, TNFSF11, IL6, IL1B, TNFRSF11B
2serine-type endopeptidase activityGO:00425211.1CTSC, LTF, MMP8, ELANE
3interleukin-1 receptor bindingGO:00514910.6IL1A, IL1B, IL1RN

Products for genes affiliated with Periodontitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Periodontitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet