MCID: PRS016
MIFTS: 31

Periosteal Chondrosarcoma malady

Categories: Cancer diseases

Aliases & Classifications for Periosteal Chondrosarcoma

Aliases & Descriptions for Periosteal Chondrosarcoma:

Name: Periosteal Chondrosarcoma 12 14
Juxtacortical Chondrosarcoma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5859

Summaries for Periosteal Chondrosarcoma

MalaCards based summary : Periosteal Chondrosarcoma, also known as juxtacortical chondrosarcoma, is related to chondrosarcoma and periostitis, and has symptoms including pain An important gene associated with Periosteal Chondrosarcoma is EXT1 (Exostosin Glycosyltransferase 1), and among its related pathways/superpathways are Cellular Senescence and Glioma. Affiliated tissues include bone, and related phenotypes are growth/size/body region and behavior/neurological

Related Diseases for Periosteal Chondrosarcoma

Diseases related to Periosteal Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
id Related Disease Score Top Affiliating Genes
1 chondrosarcoma 10.4
2 periostitis 10.4
3 neuropathy, ataxia, and retinitis pigmentosa 10.2 EXT1 IDH1
4 rommen mueller sybert syndrome 10.1 CDK4 MDM2
5 brain oligodendroglioma 10.1 IDH1 MDM2
6 macrosomia with microphthalmia, lethal 10.1 EXT1 IDH1 PTHLH
7 strabismus 10.1 CTNNB1 PTHLH
8 primary eye hypotony 10.1 CDK4 MDM2
9 amelogenesis imperfecta-gingival hyperplasia syndrome 10.1 CDK4 MDM2
10 blood protein disease 10.1 CDK4 MDM2
11 cerebral arterial disease 10.1 CTNNB1 MDM2
12 13q12.3 microdeletion syndrome 10.1 CDKN2A PTHLH
13 liposarcoma of bone 10.1 CDK4 MDM2
14 bone leiomyosarcoma 10.1 CDK4 MDM2
15 angioma hereditary neurocutaneous 10.1 CDKN2A IDH1
16 localized hypertrophic neuropathy 10.0 CDK4 MDM2
17 intracranial liposarcoma 10.0 CDK4 MDM2
18 extraosseous osteosarcoma 10.0 CDK4 MDM2
19 transverse colon cancer 10.0 CTNNB1 EXT1 PTHLH
20 pinta disease 10.0 CDK4 MDM2
21 hormone producing pituitary cancer 10.0 CDK4 MDM2
22 mental retardation, autosomal recessive 40 10.0 EXT1 MDM2 PTHLH
23 childhood central nervous system primitive neuroectodermal neoplasm 10.0 CTNNB1 IDH1 MDM2
24 pleural lipoma 10.0 CDK4 MDM2
25 juvenile astrocytoma 10.0 CDK4 IDH1 RB1
26 endometrial squamous cell carcinoma 10.0 CDKN2A MDM2
27 brain stem angioblastoma 10.0 CDK4 IDH1 MDM2
28 mediastinum liposarcoma 10.0 CDKN2A MDM2
29 childhood immature teratoma of ovary 10.0 CDK4 MDM2
30 osteomyelitis 9.9 CDK4 MDM2 RB1
31 gestational choriocarcinoma 9.9 CDK4 EXT1 MDM2
32 endometrial disease 9.9 CDK4 CDKN2A
33 ovarian epithelial cancer 9.9 EXT1 PTHLH
34 conventional central osteosarcoma 9.9 CDK4 MDM2 PTHLH
35 enchondromatosis dwarfism deafness 9.9 CDK4 CTNNB1 MDM2
36 nasopharyngeal carcinoma 9.9 CDKN2A IDH1 MDM2
37 ossifying fibromyxoid tumor 9.9 CDK4 CDKN2A
38 bone squamous cell carcinoma 9.9 CDKN2A CTNNB1 RB1
39 pseudo-meigs syndrome 9.9 CDKN2A CTNNB1
40 cervical verrucous carcinoma 9.9 CDKN2A MDM2 RB1
41 vascular myelopathy 9.8 CDKN2A MDM2
42 thanatophoric dysplasia, type ii 9.8 CDKN2A MDM2 RB1
43 glomeruloid hemangioma 9.8 CDK4 CDKN2A IDH1
44 extranodal nasal nk/t cell lymphoma 9.8 CDK4 CDKN2A RB1
45 ladd syndrome 9.8 CDKN2A MDM2 RB1
46 metachronous osteosarcoma of the bone 9.8 CDK4 IDH1 MDM2 PTHLH
47 in situ pulmonary adenocarcinoma 9.8 CDKN2A CTNNB1 MDM2
48 hypogonadotropic hypogonadism 20 with or without anosmia 9.8 CDK4 CDKN2A RB1
49 aortic aneurysm 9.8 CDK4 CDKN2A MDM2
50 episodic ataxia 9.8 CDK4 CDKN2A MDM2

Graphical network of the top 20 diseases related to Periosteal Chondrosarcoma:



Diseases related to Periosteal Chondrosarcoma

Symptoms & Phenotypes for Periosteal Chondrosarcoma

UMLS symptoms related to Periosteal Chondrosarcoma:


pain

MGI Mouse Phenotypes related to Periosteal Chondrosarcoma:

44 (show all 25)
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.18 CDK4 CDKN2A CTNNB1 EXT1 IDH1 MDM2
2 behavior/neurological MP:0005386 10.17 CDK4 CDKN2A CTNNB1 EXT1 MDM2 PTHLH
3 cellular MP:0005384 10.16 CDK4 CDKN2A CTNNB1 EXT1 MDM2 PTHLH
4 digestive/alimentary MP:0005381 10.14 MDM2 PTHLH RB1 CDK4 CDKN2A CTNNB1
5 hematopoietic system MP:0005397 10.11 CDK4 CDKN2A CTNNB1 IDH1 MDM2 PTHLH
6 homeostasis/metabolism MP:0005376 10.1 CDK4 CDKN2A CTNNB1 IDH1 MDM2 PTHLH
7 mortality/aging MP:0010768 10.1 CDK4 CDKN2A CTNNB1 EXT1 IDH1 MDM2
8 cardiovascular system MP:0005385 10.09 CDK4 CDKN2A CTNNB1 MDM2 PTHLH RB1
9 immune system MP:0005387 10.09 CDK4 CDKN2A CTNNB1 IDH1 MDM2 PTHLH
10 integument MP:0010771 10.08 CDK4 CDKN2A CTNNB1 EXT1 MDM2 PTHLH
11 embryo MP:0005380 10.07 CDK4 CDKN2A CTNNB1 EXT1 MDM2 RB1
12 endocrine/exocrine gland MP:0005379 10.06 CDK4 CDKN2A CTNNB1 MDM2 PTHLH RB1
13 craniofacial MP:0005382 10 CTNNB1 EXT1 MDM2 PTHLH RB1
14 nervous system MP:0003631 9.98 CDK4 CDKN2A CTNNB1 EXT1 MDM2 PTHLH
15 neoplasm MP:0002006 9.93 CDK4 CDKN2A CTNNB1 EXT1 MDM2 RB1
16 limbs/digits/tail MP:0005371 9.92 MDM2 PTHLH RB1 CTNNB1 EXT1
17 liver/biliary system MP:0005370 9.91 CDK4 CDKN2A CTNNB1 MDM2 RB1
18 muscle MP:0005369 9.88 CDK4 CDKN2A CTNNB1 MDM2 RB1
19 no phenotypic analysis MP:0003012 9.8 CDKN2A CTNNB1 EXT1 MDM2 RB1
20 pigmentation MP:0001186 9.77 CDK4 CDKN2A CTNNB1 MDM2 RB1
21 reproductive system MP:0005389 9.73 PTHLH RB1 CDK4 CDKN2A CTNNB1 MDM2
22 renal/urinary system MP:0005367 9.72 CDK4 CTNNB1 MDM2 PTHLH RB1
23 respiratory system MP:0005388 9.55 CTNNB1 IDH1 PTHLH RB1 CDKN2A
24 skeleton MP:0005390 9.5 CDKN2A CTNNB1 EXT1 IDH1 MDM2 PTHLH
25 vision/eye MP:0005391 9.1 CDK4 CDKN2A CTNNB1 EXT1 PTHLH RB1

Drugs & Therapeutics for Periosteal Chondrosarcoma

Search Clinical Trials , NIH Clinical Center for Periosteal Chondrosarcoma

Genetic Tests for Periosteal Chondrosarcoma

Anatomical Context for Periosteal Chondrosarcoma

MalaCards organs/tissues related to Periosteal Chondrosarcoma:

39
Bone

Publications for Periosteal Chondrosarcoma

Articles related to Periosteal Chondrosarcoma:

(show all 21)
id Title Authors Year
1
Diagnosis and Outcome of Periosteal Chondrosarcoma in Two Cats. ( 27487347 )
2016
2
Periosteal chondrosarcoma: a histopathological and molecular analysis of a rare chondrosarcoma subtype. ( 25648524 )
2015
3
Bony metastases following complete resection of periosteal chondrosarcoma. ( 25889026 )
2015
4
The presentation, treatment and outcome of periosteal chondrosarcoma in the Netherlands. ( 24891585 )
2014
5
Usefulness of PET/CT for diagnosis of periosteal chondrosarcoma of the femur: A case report. ( 24932240 )
2014
6
Periosteal chondrosarcoma of metacarpal bone: Report of a rare entity. ( 23289049 )
2012
7
IDH1 mutations are not found in cartilaginous tumours other than central and periosteal chondrosarcomas and enchondromas. ( 22074484 )
2012
8
Periosteal chondrosarcoma of the foot: a case report. ( 20576447 )
2010
9
Periosteal chondrosarcoma. ( 19098166 )
2009
10
Periosteal chondrosarcoma with microscopic cortical invasion. ( 18696199 )
2008
11
Survivorship analysis in patients with periosteal chondrosarcoma. ( 16826117 )
2006
12
Periosteal chondrosarcoma in a 9-year-old girl with osteochondromatosis. ( 15723209 )
2005
13
Periosteal chondrosarcoma. ( 12938935 )
2003
14
Periosteal chondrosarcoma. ( 12195911 )
2002
15
DNA ploidy alterations detected during dedifferentiation of periosteal chondrosarcoma. ( 10472345 )
1999
16
Periosteal chondrosarcoma: a case report and review of the literature. ( 9111097 )
1997
17
Periosteal chondrosarcoma invading the medullary cavity. ( 9229422 )
1997
18
Juxtacortical dedifferentiated chondrosarcoma from a primary periosteal chondrosarcoma. ( 8685228 )
1996
19
MR appearance of periosteal chondrosarcoma of the foot. ( 7822524 )
1995
20
Periosteal chondroma and periosteal chondrosarcoma. ( 4051099 )
1985
21
Periosteal chondrosarcoma and periosteal osteosarcoma. Two distinct entities. ( 7096408 )
1982

Variations for Periosteal Chondrosarcoma

Expression for Periosteal Chondrosarcoma

Search GEO for disease gene expression data for Periosteal Chondrosarcoma.

Pathways for Periosteal Chondrosarcoma

Pathways related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

(show all 34)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.9 CDK4 CDKN2A MDM2 RB1
2
Show member pathways
12.79 CDK4 CDKN2A CTNNB1 MDM2 RB1
3
Show member pathways
12.38 CDK4 CDKN2A MDM2 RB1
4
Show member pathways
12.31 CTNNB1 EXT1 PTHLH
5 12.31 CDK4 CDKN2A MDM2 RB1
6 12.25 CDK4 CDKN2A CTNNB1 MDM2 RB1
7 12.23 CDK4 CDKN2A CTNNB1 RB1
8 12.22 CDK4 CTNNB1 RB1
9
Show member pathways
12.21 CDK4 CTNNB1 RB1
10
Show member pathways
12.17 CDK4 CDKN2A MDM2 RB1
11 12.16 CDK4 CDKN2A MDM2 RB1
12
Show member pathways
12.15 CDK4 CDKN2A RB1
13
Show member pathways
12.07 CDK4 MDM2 RB1
14 12.06 CDK4 CDKN2A MDM2 RB1
15
Show member pathways
12.03 CDK4 CDKN2A RB1
16
Show member pathways
12 CDK4 MDM2 RB1
17 11.9 CDK4 CDKN2A MDM2
18 11.86 CDK4 CTNNB1 MDM2 RB1
19 11.83 CDKN2A CTNNB1 MDM2
20 11.79 CDKN2A MDM2 RB1
21
Show member pathways
11.77 CDK4 CDKN2A MDM2 RB1
22 11.71 CTNNB1 MDM2 RB1
23 11.69 CDK4 MDM2 RB1
24 11.47 CDKN2A CTNNB1 MDM2 RB1
25 11.39 CDKN2A MDM2
26 11.37 CDKN2A RB1
27 11.32 CDK4 MDM2 RB1
28 11.29 CDK4 MDM2
29 11.21 CDK4 RB1
30 11.12 CDK4 CDKN2A MDM2 RB1
31 11.09 CDK4 CDKN2A MDM2
32 11.07 CDK4 CDKN2A CTNNB1 MDM2 RB1
33
Show member pathways
10.96 CDKN2A MDM2
34 10.67 CDKN2A MDM2 RB1

GO Terms for Periosteal Chondrosarcoma

Cellular components related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.43 CDK4 CDKN2A CTNNB1 MDM2 PTHLH RB1
2 transcription factor complex GO:0005667 8.8 CDK4 CTNNB1 RB1

Biological processes related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.72 CDK4 CDKN2A CTNNB1
2 response to drug GO:0042493 9.71 CDK4 CTNNB1 MDM2
3 negative regulation of transcription, DNA-templated GO:0045892 9.71 CDKN2A CTNNB1 MDM2 RB1
4 negative regulation of gene expression GO:0010629 9.61 CTNNB1 MDM2 RB1
5 positive regulation of cell proliferation GO:0008284 9.56 CDK4 CTNNB1 MDM2 PTHLH
6 androgen receptor signaling pathway GO:0030521 9.52 CTNNB1 RB1
7 positive regulation of cell cycle GO:0045787 9.51 CDK4 MDM2
8 skeletal system development GO:0001501 9.5 CTNNB1 EXT1 PTHLH
9 protein destabilization GO:0031648 9.49 CDKN2A MDM2
10 response to steroid hormone GO:0048545 9.48 IDH1 MDM2
11 negative regulation of cell cycle arrest GO:0071157 9.46 CDK4 MDM2
12 negative regulation of cell proliferation GO:0008285 9.46 CDKN2A CTNNB1 PTHLH RB1
13 negative regulation of chondrocyte differentiation GO:0032331 9.37 CTNNB1 PTHLH
14 G1/S transition of mitotic cell cycle GO:0000082 9.13 CDK4 CDKN2A RB1
15 regulation of gene expression GO:0010468 8.92 CDK4 CTNNB1 MDM2 PTHLH

Molecular functions related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.5 CDKN2A CTNNB1 RB1
2 androgen receptor binding GO:0050681 9.26 CTNNB1 RB1
3 RNA polymerase II activating transcription factor binding GO:0001102 9.16 CTNNB1 RB1
4 SUMO transferase activity GO:0019789 8.96 CDKN2A MDM2
5 disordered domain specific binding GO:0097718 8.8 CTNNB1 MDM2 RB1

Sources for Periosteal Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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