MCID: PRS016
MIFTS: 31

Periosteal Chondrosarcoma malady

Category: Cancer diseases

Aliases & Classifications for Periosteal Chondrosarcoma

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Aliases & Descriptions for Periosteal Chondrosarcoma:

Name: Periosteal Chondrosarcoma 11 13
 
Juxtacortical Chondrosarcoma 68

Classifications:



External Ids:

Disease Ontology11 DOID:5859

Summaries for Periosteal Chondrosarcoma

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MalaCards based summary: Periosteal Chondrosarcoma, also known as juxtacortical chondrosarcoma, is related to chondrosarcoma and periostitis, and has symptoms including pain An important gene associated with Periosteal Chondrosarcoma is EXT1 (Exostosin Glycosyltransferase 1), and among its related pathways are Id Signaling Pathway and FOXM1 transcription factor network. Affiliated tissues include bone, and related mouse phenotypes are limbs/digits/tail and craniofacial.

Related Diseases for Periosteal Chondrosarcoma

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Diseases related to Periosteal Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1chondrosarcoma10.4
2periostitis10.4
3osteopetrosis and infantile neuroaxonal dystrophy10.3EXT1, PTHLH
4spinal cord glioma10.2IDH1, MDM2
5acidophil adenoma10.2CTNNB1, PTHLH
6lateral medullary syndrome10.1CTNNB1, MDM2
7chromosome 7p duplication10.1CDK4, MDM2
8fryns macrocephaly10.1EXT1, IDH1, PTHLH
9neuropathy, ataxia, and retinitis pigmentosa10.1EXT1, IDH1, PTHLH
10osteogenesis imperfecta10.1CDK4, MDM2
11familial long qt syndrome10.1CDK4, MDM2
12conjunctivitis10.1CDK4, MDM2
13conventional central osteosarcoma10.1CDK4, MDM2
14pediatric osteosarcoma10.1CDK4, MDM2
15lipoic acid synthetase deficiency10.1CDK4, MDM2
16trichorhinophalangeal syndrome, type ii10.1EXT1, IDH1, PTHLH
17spindle cell liposarcoma10.1CDK4, MDM2
18fibrosarcoma10.0CDK4, MDM2
19kidney lipoma10.0CDK4, MDM2
20cholelithiasis10.0CDK4, MDM2
21vulvar liposarcoma10.0CDK4, MDM2
22lumbosacral lipoma10.0CDK4, MDM2
23adenomyoma10.0CTNNB1, EXT1, PTHLH
2412p12.1 microdeletion syndrome10.0CDKN2A, CTNNB1
25vulvar sebaceous carcinoma10.0CDK4, MDM2
26cannabis dependence10.0EXT1, MDM2, PTHLH
27epidural neoplasm10.0CDK4, MDM2
28ampulla of vater squamous cell carcinoma9.9CDKN2A, MDM2
29melanotic medulloblastoma9.9CTNNB1, IDH1, MDM2
30sclerosing liposarcoma9.9CDKN2A, MDM2
31karak syndrome9.8CDK4, CDKN2A
32mild phosphoribosylpyrophosphate synthetase superactivity9.8CDKN2A, PTHLH
33breast capillary hemangioma9.8CDK4, IDH1, MDM2
34placental choriocarcinoma9.8CDK4, EXT1, MDM2
35rhabdomyosarcoma 2, alveolar9.8CDK4, MDM2
36hypoglossal nerve neoplasm9.8CDKN2A, MDM2
37skin lipoma9.8CDK4, MDM2, RB1
38chondroma9.8
39enchondroma9.8
40adenofibroma9.8CDK4, CDKN2A
41gastrointestinal neuroendocrine tumor9.8CDKN2A, CTNNB1
42bone osteosarcoma9.7CDK4, MDM2, PTHLH
43stromal keratitis9.7CDKN2A, CTNNB1
44vitamin d-dependent rickets, type i9.7CDK4, MDM2
45clear cell sarcoma9.7CDK4, MDM2
46childhood type dermatomyositis9.7CDKN2A, CTNNB1
47emerinopathy9.7CDK4, CTNNB1, MDM2
48cervix endometrial stromal tumor9.7CDKN2A, CTNNB1
49early myoclonic encephalopathy9.6CDKN2A, IDH1, MDM2
50grade iii astrocytoma9.6CDKN2A, IDH1, MDM2

Graphical network of the top 20 diseases related to Periosteal Chondrosarcoma:



Diseases related to periosteal chondrosarcoma

Symptoms & Phenotypes for Periosteal Chondrosarcoma

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UMLS symptoms related to Periosteal Chondrosarcoma:


pain

MGI Mouse Phenotypes related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

41 (show all 26)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.6CTNNB1, EXT1, MDM2, PTHLH, RB1
2MP:00053828.5CTNNB1, EXT1, MDM2, PTHLH, RB1
3MP:00028738.3CDK4, CTNNB1, EXT1, MDM2, RB1
4MP:00053888.3CDKN2A, CTNNB1, IDH1, PTHLH, RB1
5MP:00030128.2CDKN2A, CTNNB1, EXT1, MDM2, RB1
6MP:00053698.0CDK4, CDKN2A, CTNNB1, MDM2, RB1
7MP:00053708.0CDK4, CDKN2A, CTNNB1, MDM2, RB1
8MP:00011867.9CDK4, CDKN2A, CTNNB1, MDM2, RB1
9MP:00053677.9CDK4, CTNNB1, MDM2, PTHLH, RB1
10MP:00053807.7CDK4, CDKN2A, CTNNB1, EXT1, MDM2, RB1
11MP:00020067.6CDK4, CDKN2A, CTNNB1, EXT1, MDM2, RB1
12MP:00053917.6CDK4, CDKN2A, CTNNB1, EXT1, PTHLH, RB1
13MP:00053797.5CDK4, CDKN2A, CTNNB1, MDM2, PTHLH, RB1
14MP:00053897.5CDK4, CDKN2A, CTNNB1, MDM2, PTHLH, RB1
15MP:00053907.4CDKN2A, CTNNB1, EXT1, IDH1, MDM2, PTHLH
16MP:00053847.1CDK4, CDKN2A, CTNNB1, EXT1, MDM2, PTHLH
17MP:00107717.1CDK4, CDKN2A, CTNNB1, EXT1, MDM2, PTHLH
18MP:00053857.0CDK4, CDKN2A, CTNNB1, MDM2, PTHLH, RB1
19MP:00053877.0CDK4, CDKN2A, CTNNB1, IDH1, MDM2, PTHLH
20MP:00053976.9CDK4, CDKN2A, CTNNB1, IDH1, MDM2, PTHLH
21MP:00053866.9CDK4, CDKN2A, CTNNB1, EXT1, MDM2, PTHLH
22MP:00036316.8CDK4, CDKN2A, CTNNB1, EXT1, MDM2, PTHLH
23MP:00053766.7CDK4, CDKN2A, CTNNB1, IDH1, MDM2, PTHLH
24MP:00107686.6CDK4, CDKN2A, CTNNB1, EXT1, IDH1, MDM2
25MP:00053786.5CDK4, CDKN2A, CTNNB1, EXT1, IDH1, MDM2
26MP:00053816.5CDK4, CDKN2A, CTNNB1, EXT1, MDM2, PTHLH

Drugs & Therapeutics for Periosteal Chondrosarcoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Periosteal Chondrosarcoma

Genetic Tests for Periosteal Chondrosarcoma

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Anatomical Context for Periosteal Chondrosarcoma

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MalaCards organs/tissues related to Periosteal Chondrosarcoma:

36
Bone

Publications for Periosteal Chondrosarcoma

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Articles related to Periosteal Chondrosarcoma:

(show all 21)
idTitleAuthorsYear
1
Diagnosis and Outcome of Periosteal Chondrosarcoma in Two Cats. (27487347)
2016
2
Bony metastases following complete resection of periosteal chondrosarcoma. (25889026)
2015
3
Periosteal chondrosarcoma: a histopathological and molecular analysis of a rare chondrosarcoma subtype. (25648524)
2015
4
Usefulness of PET/CT for diagnosis of periosteal chondrosarcoma of the femur: A case report. (24932240)
2014
5
The presentation, treatment and outcome of periosteal chondrosarcoma in the Netherlands. (24891585)
2014
6
Periosteal chondrosarcoma of metacarpal bone: Report of a rare entity. (23289049)
2012
7
IDH1 mutations are not found in cartilaginous tumours other than central and periosteal chondrosarcomas and enchondromas. (22074484)
2012
8
Periosteal chondrosarcoma of the foot: a case report. (20576447)
2010
9
Periosteal chondrosarcoma. (19098166)
2009
10
Periosteal chondrosarcoma with microscopic cortical invasion. (18696199)
2008
11
Survivorship analysis in patients with periosteal chondrosarcoma. (16826117)
2006
12
Periosteal chondrosarcoma in a 9-year-old girl with osteochondromatosis. (15723209)
2005
13
Periosteal chondrosarcoma. (12938935)
2003
14
Periosteal chondrosarcoma. (12195911)
2002
15
DNA ploidy alterations detected during dedifferentiation of periosteal chondrosarcoma. (10472345)
1999
16
Periosteal chondrosarcoma invading the medullary cavity. (9229422)
1997
17
Periosteal chondrosarcoma: a case report and review of the literature. (9111097)
1997
18
Juxtacortical dedifferentiated chondrosarcoma from a primary periosteal chondrosarcoma. (8685228)
1996
19
MR appearance of periosteal chondrosarcoma of the foot. (7822524)
1995
20
Periosteal chondroma and periosteal chondrosarcoma. (4051099)
1985
21
Periosteal chondrosarcoma and periosteal osteosarcoma. Two distinct entities. (7096408)
1982

Variations for Periosteal Chondrosarcoma

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Expression for genes affiliated with Periosteal Chondrosarcoma

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Search GEO for disease gene expression data for Periosteal Chondrosarcoma.

Pathways for genes affiliated with Periosteal Chondrosarcoma

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Pathways related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

(show all 31)
idSuper pathwaysScoreTop Affiliating Genes
19.5CTNNB1, RB1
29.4CDK4, RB1
39.3CDK4, MDM2
4
Show member pathways
9.1CDKN2A, MDM2
59.1CDKN2A, MDM2
69.0CTNNB1, MDM2, RB1
7
Show member pathways
8.9CDK4, MDM2, RB1
88.9CDK4, MDM2, RB1
9
Show member pathways
8.9CDK4, MDM2, RB1
108.9CDK4, CTNNB1, RB1
118.9CDK4, CTNNB1, RB1
128.8CDK4, CTNNB1, MDM2
138.7CDKN2A, MDM2, RB1
148.7CDKN2A, MDM2, RB1
15
Show member pathways
8.6CDK4, CDKN2A, RB1
16
Show member pathways
8.6CDK4, CDKN2A, RB1
178.5CDK4, CDKN2A, MDM2
18
Show member pathways
8.5CDK4, CDKN2A, MDM2
198.4CDK4, CTNNB1, MDM2, RB1
208.2CDKN2A, CTNNB1, MDM2, RB1
21
Show member pathways
8.1CDK4, CDKN2A, MDM2, RB1
228.1CDK4, CDKN2A, MDM2, RB1
23
Show member pathways
8.1CDK4, CDKN2A, MDM2, RB1
24
Show member pathways
8.1CDK4, CDKN2A, MDM2, RB1
25
Show member pathways
8.1CDK4, CDKN2A, MDM2, RB1
268.1CDK4, CDKN2A, MDM2, RB1
278.1CDK4, CDKN2A, MDM2, RB1
288.1CDK4, CDKN2A, CTNNB1, RB1
297.6CDK4, CDKN2A, CTNNB1, MDM2, RB1
307.6CDK4, CDKN2A, CTNNB1, MDM2, RB1
31
Show member pathways
7.6CDK4, CDKN2A, CTNNB1, MDM2, RB1

GO Terms for genes affiliated with Periosteal Chondrosarcoma

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Cellular components related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:00056678.9CDK4, CTNNB1, RB1

Biological processes related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1androgen receptor signaling pathwayGO:003052110.3CTNNB1, RB1
2myoblast differentiationGO:004544510.3CTNNB1, RB1
3negative regulation of chondrocyte differentiationGO:003233110.2CTNNB1, PTHLH
4response to steroid hormoneGO:004854510.1IDH1, MDM2
5negative regulation of cell cycle arrestGO:007115710.1CDK4, MDM2
6positive regulation of cell cycleGO:004578710.0CDK4, MDM2
7negative regulation of gene expressionGO:00106299.7CTNNB1, MDM2, RB1
8G1/S transition of mitotic cell cycleGO:00000829.4CDK4, CDKN2A, RB1
9skeletal system developmentGO:00015019.2CTNNB1, EXT1, PTHLH
10negative regulation of cell proliferationGO:00082859.0CDKN2A, CTNNB1, PTHLH, RB1
11positive regulation of cell proliferationGO:00082849.0CDK4, CTNNB1, MDM2, PTHLH
12regulation of gene expressionGO:00104688.9CDK4, CTNNB1, MDM2, PTHLH
13negative regulation of transcription, DNA-templatedGO:00458928.9CDKN2A, CTNNB1, MDM2, RB1

Molecular functions related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1androgen receptor bindingGO:005068110.0CTNNB1, RB1
2RNA polymerase II activating transcription factor bindingGO:00011029.5CTNNB1, RB1

Sources for Periosteal Chondrosarcoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet