MCID: PRS016
MIFTS: 29

Periosteal Chondrosarcoma malady

Cancer diseases category

Aliases & Classifications for Periosteal Chondrosarcoma

About this section

Aliases & Descriptions for Periosteal Chondrosarcoma:

Name: Periosteal Chondrosarcoma 10
 
Juxtacortical Chondrosarcoma 65


Classifications:



External Ids:

Disease Ontology10 DOID:5859

Summaries for Periosteal Chondrosarcoma

About this section
MalaCards based summary: Periosteal Chondrosarcoma, also known as juxtacortical chondrosarcoma, is related to chondrosarcoma and periostitis. An important gene associated with Periosteal Chondrosarcoma is EXT1 (Exostosin Glycosyltransferase 1), and among its related pathways are DNA damage_ATM/ATR regulation of G1/S checkpoint and TP53 network. Affiliated tissues include bone, and related mouse phenotypes are pigmentation and craniofacial.

Related Diseases for Periosteal Chondrosarcoma

About this section

Diseases related to Periosteal Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1chondrosarcoma31.0CDK4, EXT1, MDM2, PTHLH
2periostitis10.9
3chondroma10.2
4enchondroma10.2
5acantholytic variant squamous cell breast carcinoma10.1IDH1, MDM2
6ring chromosome 810.1CDK4, MDM2
7osteodysplasia familial anderson type10.1EXT1, PTHLH
8antenatal multiminicore disease with arthrogryposis multiplex congenita10.1CDK4, MDM2
9cheek mucosa cancer10.1CDK4, MDM2
10bone remodeling disease10.1CDK4, MDM2
11angioedema10.1CDKN2A, MDM2
12lipodermatosclerosis10.1CDK4, MDM2
13spindle cell liposarcoma10.1CDKN2A, MDM2
14laryngeal mucoepidermoid carcinoma10.1CDK4, MDM2
15heart septal defect10.1CDKN2A, MDM2
16metabolic syndrome x10.1CDK4, MDM2
17atypical mycobacteriosis, familial10.1CDK4, CDKN2A
18fallopian tube squamous cell carcinoma10.1CDKN2A, PTHLH
19facial injuries and disorders10.1MDM2, RB1
20extrahepatic bile duct lipoma10.1CDK4, MDM2
21malignant eyelid melanoma10.1CDK4, CDKN2A
22lumbosacral lipoma10.1CDK4, MDM2
23adams-oliver syndrome10.1EXT1, IDH1, PTHLH
24hydranencephaly10.1EXT1, IDH1, PTHLH
25gliosarcoma10.1IDH1, MDM2
26malignant ovarian surface epithelial-stromal neoplasm10.1CDK4, MDM2
27autosomal recessive cerebellar ataxia-epilepsy-intellectual disability syndrome due to tud deficiency10.1CDKN2A, PTHLH
28angiomyolipoma10.1CDK4, MDM2
29malignant gastric germ cell tumor10.1CDK4, MDM2
30pilodental dysplasia with refractive errors10.0CDKN2A, IDH1
31breast rhabdomyosarcoma10.0CTNNB1, PTHLH
32myxoid liposarcoma10.0CDK4, MDM2
33connective tissue disease10.0CDK4, EXT1, MDM2
34juxtacortical osteosarcoma10.0CTNNB1, PTHLH
35cryptococcosis10.0CTNNB1, MDM2
36keratoacanthoma10.0CDK4, MDM2, PTHLH
37peripheral primitive neuroectodermal tumor10.0CDK4, MDM2, PTHLH
38histiocytosis10.0CDK4, MDM2
39adenocarcinoma in situ9.9CDK4, CDKN2A, MDM2
40autosomal dominant charcot-marie-tooth disease type 2a29.9CDK4, CDKN2A, MDM2
41atypical polypoid adenomyoma9.9CDK4, CDKN2A, MDM2
42autosomal dominant charcot-marie-tooth disease type 2f9.9CDK4, CDKN2A, MDM2
43developmental and speech delay due to sox5 deficiency9.9CDKN2A, CTNNB1
44juvenile astrocytoma9.9CDK4, CDKN2A, MDM2
45liposarcoma of the ovary9.9CDK4, CDKN2A, MDM2
46grade iii astrocytoma9.9CDK4, IDH1, RB1
47uveitis9.9CDK4, CDKN2A, MDM2
48anterior compartment syndrome9.9CTNNB1, EXT1, PTHLH
49esophageal lipoma9.9CDK4, MDM2, RB1
50bronchogenic lung adenocarcinoma9.9CDKN2A, MDM2, RB1

Graphical network of the top 20 diseases related to Periosteal Chondrosarcoma:



Diseases related to periosteal chondrosarcoma

Symptoms for Periosteal Chondrosarcoma

About this section

Drugs & Therapeutics for Periosteal Chondrosarcoma

About this section

Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Periosteal Chondrosarcoma

Genetic Tests for Periosteal Chondrosarcoma

About this section

Anatomical Context for Periosteal Chondrosarcoma

About this section

MalaCards organs/tissues related to Periosteal Chondrosarcoma:

33
Bone

Animal Models for Periosteal Chondrosarcoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Periosteal Chondrosarcoma:

38 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.6CDKN2A, CTNNB1, MDM2, RB1
2MP:00053828.3CTNNB1, EXT1, MDM2, PTHLH, RB1
3MP:00053718.2CTNNB1, EXT1, MDM2, PTHLH, RB1
4MP:00030128.2CDKN2A, CTNNB1, EXT1, MDM2, RB1
5MP:00053707.9CDK4, CDKN2A, CTNNB1, MDM2, RB1
6MP:00053697.9CDK4, CDKN2A, CTNNB1, MDM2, RB1
7MP:00053907.7CDKN2A, CTNNB1, EXT1, MDM2, PTHLH, RB1
8MP:00053797.6CDK4, CDKN2A, CTNNB1, PTHLH, RB1
9MP:00053807.5CDK4, CDKN2A, CTNNB1, EXT1, MDM2, RB1
10MP:00053917.5CDK4, CDKN2A, CTNNB1, EXT1, PTHLH, RB1
11MP:00020067.3CDK4, CDKN2A, CTNNB1, EXT1, MDM2, RB1
12MP:00053817.2CDK4, CDKN2A, CTNNB1, EXT1, MDM2, PTHLH
13MP:00053847.1CDK4, CDKN2A, CTNNB1, EXT1, MDM2, PTHLH
14MP:00107687.0CDK4, CDKN2A, CTNNB1, EXT1, MDM2, PTHLH
15MP:00053787.0CDK4, CDKN2A, CTNNB1, EXT1, MDM2, PTHLH
16MP:00107717.0CDK4, CDKN2A, CTNNB1, EXT1, MDM2, PTHLH
17MP:00053866.9CDK4, CDKN2A, CTNNB1, EXT1, MDM2, PTHLH
18MP:00036316.8CDK4, CDKN2A, CTNNB1, EXT1, MDM2, PTHLH
19MP:00053896.8CDK4, CDKN2A, CTNNB1, MDM2, PTHLH, RB1
20MP:00053876.7CDK4, CDKN2A, CTNNB1, IDH1, MDM2, PTHLH
21MP:00053976.6CDK4, CDKN2A, CTNNB1, IDH1, MDM2, PTHLH

Publications for Periosteal Chondrosarcoma

About this section

Articles related to Periosteal Chondrosarcoma:

(show all 20)
idTitleAuthorsYear
1
Periosteal chondrosarcoma: a histopathological and molecular analysis of a rare chondrosarcoma subtype. (25648524)
2015
2
Bony metastases following complete resection of periosteal chondrosarcoma. (25889026)
2015
3
Usefulness of PET/CT for diagnosis of periosteal chondrosarcoma of the femur: A case report. (24932240)
2014
4
The presentation, treatment and outcome of periosteal chondrosarcoma in the Netherlands. (24891585)
2014
5
IDH1 mutations are not found in cartilaginous tumours other than central and periosteal chondrosarcomas and enchondromas. (22074484)
2012
6
Periosteal chondrosarcoma of metacarpal bone: Report of a rare entity. (23289049)
2012
7
Periosteal chondrosarcoma of the foot: a case report. (20576447)
2010
8
Periosteal chondrosarcoma. (19098166)
2009
9
Periosteal chondrosarcoma with microscopic cortical invasion. (18696199)
2008
10
Survivorship analysis in patients with periosteal chondrosarcoma. (16826117)
2006
11
Periosteal chondrosarcoma in a 9-year-old girl with osteochondromatosis. (15723209)
2005
12
Periosteal chondrosarcoma. (12938935)
2003
13
Periosteal chondrosarcoma. (12195911)
2002
14
DNA ploidy alterations detected during dedifferentiation of periosteal chondrosarcoma. (10472345)
1999
15
Periosteal chondrosarcoma invading the medullary cavity. (9229422)
1997
16
Periosteal chondrosarcoma: a case report and review of the literature. (9111097)
1997
17
Juxtacortical dedifferentiated chondrosarcoma from a primary periosteal chondrosarcoma. (8685228)
1996
18
MR appearance of periosteal chondrosarcoma of the foot. (7822524)
1995
19
Periosteal chondroma and periosteal chondrosarcoma. (4051099)
1985
20
Periosteal chondrosarcoma and periosteal osteosarcoma. Two distinct entities. (7096408)
1982

Variations for Periosteal Chondrosarcoma

About this section

Expression for genes affiliated with Periosteal Chondrosarcoma

About this section
Search GEO for disease gene expression data for Periosteal Chondrosarcoma.

Pathways for genes affiliated with Periosteal Chondrosarcoma

About this section

Pathways related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CDK4, MDM2
2
Show member pathways
9.5CDKN2A, MDM2
39.3CDK4, RB1
49.0CDK4, CDKN2A, MDM2
58.9CDK4, MDM2, RB1
6
Show member pathways
8.9CDK4, MDM2, RB1
7
Show member pathways
8.9CDK4, MDM2, RB1
88.9CDKN2A, MDM2, RB1
98.9CDKN2A, MDM2, RB1
10
Show member pathways
8.8CDK4, CDKN2A, RB1
11
Show member pathways
8.8CDK4, CDKN2A, RB1
128.7CDK4, CTNNB1, MDM2
13
Wnt Signaling Pathway (WikiPathways)
Show member pathways
8.7CDK4, CTNNB1, MDM2
148.6CTNNB1, MDM2, RB1
15
B Cell Receptor Signaling Pathway (WikiPathways)
Show member pathways
8.5CTNNB1, MDM2, RB1
168.5CDK4, CTNNB1, RB1
17
Show member pathways
8.4CDK4, CDKN2A, MDM2, RB1
18
Show member pathways
8.4CDK4, CDKN2A, MDM2, RB1
198.4CDK4, CDKN2A, MDM2, RB1
20
Show member pathways
8.4CDK4, CDKN2A, MDM2, RB1
218.4CDK4, CDKN2A, MDM2, RB1
228.4CDK4, CDKN2A, MDM2, RB1
238.4CDK4, CDKN2A, MDM2, RB1
24
Show member pathways
8.4CDK4, CDKN2A, MDM2, RB1
258.1CDK4, CTNNB1, MDM2, RB1
268.1CDKN2A, CTNNB1, MDM2, RB1
278.0CDK4, CDKN2A, CTNNB1, RB1
28
Show member pathways
7.5CDK4, CDKN2A, CTNNB1, MDM2, RB1
297.5CDK4, CDKN2A, CTNNB1, MDM2, RB1
307.5CDK4, CDKN2A, CTNNB1, MDM2, RB1

GO Terms for genes affiliated with Periosteal Chondrosarcoma

About this section

Cellular components related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:001660410.1CDKN2A, MDM2
2transcription factor complexGO:00056678.9CDK4, CTNNB1, RB1
3nucleoplasmGO:00056547.1CDK4, CDKN2A, CTNNB1, MDM2, PTHLH, RB1

Biological processes related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1endoderm developmentGO:000749210.4EXT1, PTHLH
2negative regulation of cell cycle arrestGO:007115710.1CDK4, MDM2
3protein destabilizationGO:003164810.0CDKN2A, MDM2
4negative regulation of chondrocyte differentiationGO:00323319.8CTNNB1, PTHLH
5androgen receptor signaling pathwayGO:00305219.6CTNNB1, RB1
6G1/S transition of mitotic cell cycleGO:00000829.0CDK4, CDKN2A, RB1
7positive regulation of apoptotic processGO:00430658.9CDK4, CDKN2A, CTNNB1
8regulation of gene expressionGO:00104688.7CDK4, CTNNB1, PTHLH
9skeletal system developmentGO:00015018.6CTNNB1, EXT1, PTHLH
10positive regulation of cell proliferationGO:00082848.4CDK4, CTNNB1, MDM2, PTHLH
11negative regulation of cell proliferationGO:00082858.4CDKN2A, CTNNB1, PTHLH, RB1
12negative regulation of transcription, DNA-templatedGO:00458928.1CDKN2A, CTNNB1, MDM2, RB1

Molecular functions related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II activating transcription factor bindingGO:00011029.4CTNNB1, RB1
2androgen receptor bindingGO:00506819.4CTNNB1, RB1
3enzyme bindingGO:00198998.6CTNNB1, MDM2, RB1
4transcription factor bindingGO:00081348.2CDKN2A, CTNNB1, RB1

Sources for Periosteal Chondrosarcoma

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet