MCID: PRS016
MIFTS: 31

Periosteal Chondrosarcoma malady

Category: Cancer diseases

Aliases & Classifications for Periosteal Chondrosarcoma

About this section

Aliases & Descriptions for Periosteal Chondrosarcoma:

Name: Periosteal Chondrosarcoma 11 13
 
Juxtacortical Chondrosarcoma 68

Classifications:



External Ids:

Disease Ontology11 DOID:5859

Summaries for Periosteal Chondrosarcoma

About this section
MalaCards based summary: Periosteal Chondrosarcoma, also known as juxtacortical chondrosarcoma, is related to chondrosarcoma and periostitis, and has symptoms including pain An important gene associated with Periosteal Chondrosarcoma is EXT1 (Exostosin Glycosyltransferase 1), and among its related pathways are FOXM1 transcription factor network and DNA damage_ATM/ATR regulation of G1/S checkpoint. Affiliated tissues include bone, and related mouse phenotypes are craniofacial and limbs/digits/tail.

Related Diseases for Periosteal Chondrosarcoma

About this section

Diseases related to Periosteal Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1chondrosarcoma10.4
2periostitis10.4
3neuropathy, ataxia, and retinitis pigmentosa10.2EXT1, IDH1
4rommen mueller sybert syndrome10.1CDK4, MDM2
5brain oligodendroglioma10.1IDH1, MDM2
6macrosomia with microphthalmia, lethal10.1EXT1, IDH1, PTHLH
7strabismus10.1CTNNB1, PTHLH
8primary eye hypotony10.1CDK4, MDM2
9amelogenesis imperfecta-gingival hyperplasia syndrome10.1CDK4, MDM2
10blood protein disease10.1CDK4, MDM2
11cerebral arterial disease10.1CTNNB1, MDM2
1213q12.3 microdeletion syndrome10.1CDKN2A, PTHLH
13liposarcoma of bone10.1CDK4, MDM2
14bone leiomyosarcoma10.1CDK4, MDM2
15angioma hereditary neurocutaneous10.1CDKN2A, IDH1
16localized hypertrophic neuropathy10.0CDK4, MDM2
17intracranial liposarcoma10.0CDK4, MDM2
18extraosseous osteosarcoma10.0CDK4, MDM2
19transverse colon cancer10.0CTNNB1, EXT1, PTHLH
20pinta disease10.0CDK4, MDM2
21hormone producing pituitary cancer10.0CDK4, MDM2
22mental retardation, autosomal recessive 4010.0EXT1, MDM2, PTHLH
23childhood central nervous system primitive neuroectodermal neoplasm10.0CTNNB1, IDH1, MDM2
24pleural lipoma10.0CDK4, MDM2
25juvenile astrocytoma10.0CDK4, IDH1, RB1
26endometrial squamous cell carcinoma10.0CDKN2A, MDM2
27brain stem angioblastoma10.0CDK4, IDH1, MDM2
28mediastinum liposarcoma10.0CDKN2A, MDM2
29childhood immature teratoma of ovary10.0CDK4, MDM2
30osteomyelitis9.9CDK4, MDM2, RB1
31gestational choriocarcinoma9.9CDK4, EXT1, MDM2
32endometrial disease9.9CDK4, CDKN2A
33ovarian epithelial cancer9.9EXT1, PTHLH
34conventional central osteosarcoma9.9CDK4, MDM2, PTHLH
35enchondromatosis dwarfism deafness9.9CDK4, CTNNB1, MDM2
36nasopharyngeal carcinoma9.9CDKN2A, IDH1, MDM2
37ossifying fibromyxoid tumor9.9CDK4, CDKN2A
38bone squamous cell carcinoma9.9CDKN2A, CTNNB1, RB1
39pseudo-meigs syndrome9.9CDKN2A, CTNNB1
40cervical verrucous carcinoma9.9CDKN2A, MDM2, RB1
41vascular myelopathy9.8CDKN2A, MDM2
42thanatophoric dysplasia, type ii9.8CDKN2A, MDM2, RB1
43glomeruloid hemangioma9.8CDK4, CDKN2A, IDH1
44extranodal nasal nk/t cell lymphoma9.8CDK4, CDKN2A, RB1
45ladd syndrome9.8CDKN2A, MDM2, RB1
46metachronous osteosarcoma of the bone9.8CDK4, IDH1, MDM2, PTHLH
47in situ pulmonary adenocarcinoma9.8CDKN2A, CTNNB1, MDM2
48hypogonadotropic hypogonadism 20 with or without anosmia9.8CDK4, CDKN2A, RB1
49aortic aneurysm9.8CDK4, CDKN2A, MDM2
50episodic ataxia9.8CDK4, CDKN2A, MDM2

Graphical network of the top 20 diseases related to Periosteal Chondrosarcoma:



Diseases related to periosteal chondrosarcoma

Symptoms & Phenotypes for Periosteal Chondrosarcoma

About this section

UMLS symptoms related to Periosteal Chondrosarcoma:


pain

MGI Mouse Phenotypes related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

41 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.8CTNNB1, EXT1, MDM2, PTHLH, RB1
2MP:00053718.5CTNNB1, EXT1, MDM2, PTHLH, RB1
3MP:00053678.3CDK4, CTNNB1, MDM2, PTHLH, RB1
4MP:00053888.1CDKN2A, CTNNB1, IDH1, PTHLH, RB1
5MP:00011868.1CDK4, CDKN2A, CTNNB1, MDM2, RB1
6MP:00030127.9CDKN2A, CTNNB1, EXT1, MDM2, RB1
7MP:00053697.8CDK4, CDKN2A, CTNNB1, MDM2, RB1
8MP:00020067.7CDK4, CDKN2A, CTNNB1, EXT1, MDM2, RB1
9MP:00053807.7CDK4, CDKN2A, CTNNB1, EXT1, MDM2, RB1
10MP:00053917.6CDK4, CDKN2A, CTNNB1, EXT1, PTHLH, RB1
11MP:00053897.6CDK4, CDKN2A, CTNNB1, MDM2, PTHLH, RB1
12MP:00053707.5CDK4, CDKN2A, CTNNB1, MDM2, RB1
13MP:00053857.3CDK4, CDKN2A, CTNNB1, MDM2, PTHLH, RB1
14MP:00053907.3CDKN2A, CTNNB1, EXT1, IDH1, MDM2, PTHLH
15MP:00053797.2CDK4, CDKN2A, CTNNB1, MDM2, PTHLH, RB1
16MP:00053867.1CDK4, CDKN2A, CTNNB1, EXT1, MDM2, PTHLH
17MP:00053767.1CDK4, CDKN2A, CTNNB1, IDH1, MDM2, PTHLH
18MP:00053847.0CDK4, CDKN2A, CTNNB1, EXT1, MDM2, PTHLH
19MP:00053877.0CDK4, CDKN2A, CTNNB1, IDH1, MDM2, PTHLH
20MP:00053816.9CDK4, CDKN2A, CTNNB1, EXT1, MDM2, PTHLH
21MP:00107716.8CDK4, CDKN2A, CTNNB1, EXT1, MDM2, PTHLH
22MP:00053976.7CDK4, CDKN2A, CTNNB1, IDH1, MDM2, PTHLH
23MP:00107686.7CDK4, CDKN2A, CTNNB1, EXT1, IDH1, MDM2
24MP:00053786.7CDK4, CDKN2A, CTNNB1, EXT1, IDH1, MDM2
25MP:00036316.5CDK4, CDKN2A, CTNNB1, EXT1, MDM2, PTHLH

Drugs & Therapeutics for Periosteal Chondrosarcoma

About this section

Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Periosteal Chondrosarcoma

Genetic Tests for Periosteal Chondrosarcoma

About this section

Anatomical Context for Periosteal Chondrosarcoma

About this section

MalaCards organs/tissues related to Periosteal Chondrosarcoma:

36
Bone

Publications for Periosteal Chondrosarcoma

About this section

Articles related to Periosteal Chondrosarcoma:

(show all 21)
idTitleAuthorsYear
1
Diagnosis and Outcome of Periosteal Chondrosarcoma in Two Cats. (27487347)
2016
2
Periosteal chondrosarcoma: a histopathological and molecular analysis of a rare chondrosarcoma subtype. (25648524)
2015
3
Bony metastases following complete resection of periosteal chondrosarcoma. (25889026)
2015
4
The presentation, treatment and outcome of periosteal chondrosarcoma in the Netherlands. (24891585)
2014
5
Usefulness of PET/CT for diagnosis of periosteal chondrosarcoma of the femur: A case report. (24932240)
2014
6
Periosteal chondrosarcoma of metacarpal bone: Report of a rare entity. (23289049)
2012
7
IDH1 mutations are not found in cartilaginous tumours other than central and periosteal chondrosarcomas and enchondromas. (22074484)
2012
8
Periosteal chondrosarcoma of the foot: a case report. (20576447)
2010
9
Periosteal chondrosarcoma. (19098166)
2009
10
Periosteal chondrosarcoma with microscopic cortical invasion. (18696199)
2008
11
Survivorship analysis in patients with periosteal chondrosarcoma. (16826117)
2006
12
Periosteal chondrosarcoma in a 9-year-old girl with osteochondromatosis. (15723209)
2005
13
Periosteal chondrosarcoma. (12938935)
2003
14
Periosteal chondrosarcoma. (12195911)
2002
15
DNA ploidy alterations detected during dedifferentiation of periosteal chondrosarcoma. (10472345)
1999
16
Periosteal chondrosarcoma: a case report and review of the literature. (9111097)
1997
17
Periosteal chondrosarcoma invading the medullary cavity. (9229422)
1997
18
Juxtacortical dedifferentiated chondrosarcoma from a primary periosteal chondrosarcoma. (8685228)
1996
19
MR appearance of periosteal chondrosarcoma of the foot. (7822524)
1995
20
Periosteal chondroma and periosteal chondrosarcoma. (4051099)
1985
21
Periosteal chondrosarcoma and periosteal osteosarcoma. Two distinct entities. (7096408)
1982

Variations for Periosteal Chondrosarcoma

About this section

Expression for genes affiliated with Periosteal Chondrosarcoma

About this section
Search GEO for disease gene expression data for Periosteal Chondrosarcoma.

Pathways for genes affiliated with Periosteal Chondrosarcoma

About this section

Pathways related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

(show all 34)
idSuper pathwaysScoreTop Affiliating Genes
19.4CDK4, RB1
29.3CDK4, MDM2
39.2CDKN2A, RB1
4
Show member pathways
9.2CTNNB1, EXT1, PTHLH
5
Show member pathways
9.1CDKN2A, MDM2
69.1CDKN2A, MDM2
79.0CTNNB1, MDM2, RB1
8
Show member pathways
8.9CDK4, MDM2, RB1
9
Show member pathways
8.9CDK4, MDM2, RB1
108.9CDK4, MDM2, RB1
118.9CDK4, MDM2, RB1
128.9CDK4, CTNNB1, RB1
13
Show member pathways
8.9CDK4, CTNNB1, RB1
148.7CDKN2A, MDM2, RB1
158.7CDKN2A, MDM2, RB1
16
Show member pathways
8.6CDK4, CDKN2A, RB1
17
Show member pathways
8.6CDK4, CDKN2A, RB1
188.6CDKN2A, CTNNB1, MDM2
198.5CDK4, CDKN2A, MDM2
20
Show member pathways
8.5CDK4, CDKN2A, MDM2
218.4CDK4, CTNNB1, MDM2, RB1
228.2CDKN2A, CTNNB1, MDM2, RB1
23
Show member pathways
8.1CDK4, CDKN2A, MDM2, RB1
24
Show member pathways
8.1CDK4, CDKN2A, MDM2, RB1
25
Show member pathways
8.1CDK4, CDKN2A, MDM2, RB1
268.1CDK4, CDKN2A, MDM2, RB1
27
Show member pathways
8.1CDK4, CDKN2A, MDM2, RB1
28
Show member pathways
8.1CDK4, CDKN2A, MDM2, RB1
298.1CDK4, CDKN2A, MDM2, RB1
30
Show member pathways
8.1CDK4, CDKN2A, MDM2, RB1
318.1CDK4, CDKN2A, CTNNB1, RB1
327.6CDK4, CDKN2A, CTNNB1, MDM2, RB1
33
Show member pathways
7.6CDK4, CDKN2A, CTNNB1, MDM2, RB1
347.6CDK4, CDKN2A, CTNNB1, MDM2, RB1

GO Terms for genes affiliated with Periosteal Chondrosarcoma

About this section

Cellular components related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:00056678.9CDK4, CTNNB1, RB1
2nucleoplasmGO:00056547.7CDK4, CDKN2A, CTNNB1, MDM2, PTHLH, RB1

Biological processes related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1androgen receptor signaling pathwayGO:003052110.3CTNNB1, RB1
2negative regulation of chondrocyte differentiationGO:003233110.2CTNNB1, PTHLH
3response to steroid hormoneGO:004854510.1IDH1, MDM2
4negative regulation of cell cycle arrestGO:007115710.1CDK4, MDM2
5positive regulation of cell cycleGO:004578710.0CDK4, MDM2
6protein destabilizationGO:00316489.8CDKN2A, MDM2
7negative regulation of gene expressionGO:00106299.8CTNNB1, MDM2, RB1
8response to drugGO:00424939.4CDK4, CTNNB1, MDM2
9G1/S transition of mitotic cell cycleGO:00000829.4CDK4, CDKN2A, RB1
10positive regulation of apoptotic processGO:00430659.2CDK4, CDKN2A, CTNNB1
11skeletal system developmentGO:00015019.2CTNNB1, EXT1, PTHLH
12positive regulation of cell proliferationGO:00082849.0CDK4, CTNNB1, MDM2, PTHLH
13negative regulation of cell proliferationGO:00082859.0CDKN2A, CTNNB1, PTHLH, RB1
14regulation of gene expressionGO:00104689.0CDK4, CTNNB1, MDM2, PTHLH
15negative regulation of transcription, DNA-templatedGO:00458928.9CDKN2A, CTNNB1, MDM2, RB1

Molecular functions related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1androgen receptor bindingGO:005068110.2CTNNB1, RB1
2RNA polymerase II activating transcription factor bindingGO:000110210.2CTNNB1, RB1
3SUMO transferase activityGO:00197899.8CDKN2A, MDM2
4disordered domain specific bindingGO:00977189.7CTNNB1, MDM2, RB1
5transcription factor bindingGO:00081348.7CDKN2A, CTNNB1, RB1

Sources for Periosteal Chondrosarcoma

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet