Aliases & Classifications for Periosteal Chondrosarcoma

MalaCards integrated aliases for Periosteal Chondrosarcoma:

Name: Periosteal Chondrosarcoma 12 14
Juxtacortical Chondrosarcoma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5859

Summaries for Periosteal Chondrosarcoma

MalaCards based summary : Periosteal Chondrosarcoma, also known as juxtacortical chondrosarcoma, is related to optic disk drusen and nemaline myopathy, and has symptoms including pain An important gene associated with Periosteal Chondrosarcoma is HEY1 (Hes Related Family BHLH Transcription Factor With YRPW Motif 1), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Mitotic G1-G1/S phases. Affiliated tissues include bone, and related phenotypes are cellular and growth/size/body region

Related Diseases for Periosteal Chondrosarcoma

Diseases related to Periosteal Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
id Related Disease Score Top Affiliating Genes
1 optic disk drusen 10.7 IDH1 IDH2
2 nemaline myopathy 10.7 IDH1 IDH2
3 endolymphatic sac tumor 10.7 IDH1 IDH2
4 mixed oligodendroglioma-astrocytoma 10.7 IDH1 IDH2
5 congenital disorder of glycosylation, type if 10.7 IDH1 IDH2
6 essential pentosuria 10.6 IDH1 IDH2
7 bone osteosarcoma 10.6 IDH1 IDH2
8 breast papillomatosis 10.6 IDH1 IDH2
9 acute pre-b-cell lymphoblastic leukemia 10.6 IDH1 IDH2
10 early myoclonic encephalopathy 10.6 IDH1 IDH2
11 neurotic disorder 10.6 IDH1 IDH2
12 schwannoma of jugular foramen 10.5 IDH1 IDH2
13 chondrosarcoma 10.4
14 periostitis 10.4
15 adult oligodendroglioma 10.4 IDH1 MDM2
16 allergic hypersensitivity disease 10.4 IDH1 IDH2
17 lymphopenia 10.4 IDH1 MDM2
18 extraskeletal mesenchymal chondrosarcoma 10.4 HEY1 NCOA2
19 vascular cancer 10.4 IDH1 IDH2
20 rnase t2-deficient leukoencephalopathy 10.3 CDK4 MDM2
21 achard syndrome 10.3 IDH1 IDH2
22 primary pulmonary lymphoma 10.3 CDK4 MDM2
23 reactive arthritis 10.3 CDK4 MDM2
24 coronary aneurysm 10.3 CDK4 MDM2
25 metachronous osteosarcoma of the bone 10.3 CDK4 MDM2
26 lipoic acid biosynthesis defects 10.3 CDK4 MDM2
27 median neuropathy 10.3 CDK4 MDM2
28 localized osteosarcoma 10.3 CDK4 MDM2
29 cholelithiasis 10.2 CDK4 MDM2
30 brachydactyly 10.2 IDH1 IDH2
31 peritoneal serous adenocarcinoma 10.2 IDH1 IDH2
32 cutaneous liposarcoma 10.2 CDK4 MDM2
33 rectum squamous cell carcinoma 10.2 CDKN2A MDM2
34 ascaridiasis 10.2 CDK4 MDM2
35 mucinous intrahepatic cholangiocarcinoma 10.1 CDK4 MDM2
36 spindle cell liposarcoma 10.1 CDKN2A MDM2
37 grade iii astrocytoma 10.1 CDK4 IDH1 RB1
38 kidney lipoma 10.1 CDK4 MDM2
39 fallopian tube papillary adenocarcinoma 10.1 IDH1 IDH2
40 anca-associated vasculitis 10.1 CDKN2A IDH1 IDH2
41 breast epithelioid hemangioma 10.1 CDK4 IDH1 MDM2
42 spinal cord glioma 10.0 CDKN2A IDH1 IDH2
43 gestational choriocarcinoma 10.0 CDK4 EXT1 MDM2
44 brain angioma 10.0 CTNNB1 PTHLH
45 skin lipoma 10.0 CDK4 MDM2 RB1
46 bladder squamous cell carcinoma 10.0 CDKN2A MDM2
47 fryns macrocephaly 10.0 EXT1 IDH1 IDH2 PTHLH
48 cri-du-chat syndrome 10.0 EXT1 IDH1 IDH2 PTHLH
49 brain stem infarction 10.0 CTNNB1 MDM2
50 small cell osteogenic sarcoma 10.0 CDK4 MDM2 PTHLH

Graphical network of the top 20 diseases related to Periosteal Chondrosarcoma:



Diseases related to Periosteal Chondrosarcoma

Symptoms & Phenotypes for Periosteal Chondrosarcoma

UMLS symptoms related to Periosteal Chondrosarcoma:


pain

MGI Mouse Phenotypes related to Periosteal Chondrosarcoma:

44 (show all 21)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.24 CTNNB1 EXT1 HEY1 MDM2 NCOA2 PTHLH
2 growth/size/body region MP:0005378 10.24 CDK4 CDKN2A CTNNB1 EXT1 HEY1 IDH1
3 behavior/neurological MP:0005386 10.2 EXT1 MDM2 NCOA2 PTHLH RB1 CDK4
4 cardiovascular system MP:0005385 10.19 CDK4 CDKN2A CTNNB1 HEY1 IDH2 MDM2
5 embryo MP:0005380 10.16 NCOA2 RB1 CDK4 CDKN2A CTNNB1 EXT1
6 immune system MP:0005387 10.13 IDH1 MDM2 NCOA2 PTHLH RB1 CDK4
7 mortality/aging MP:0010768 10.13 CDK4 CDKN2A CTNNB1 EXT1 HEY1 IDH1
8 digestive/alimentary MP:0005381 10.11 CDK4 CDKN2A CTNNB1 EXT1 MDM2 PTHLH
9 integument MP:0010771 10.11 CDK4 CDKN2A CTNNB1 EXT1 MDM2 NCOA2
10 endocrine/exocrine gland MP:0005379 10.09 CDK4 CDKN2A CTNNB1 MDM2 NCOA2 PTHLH
11 craniofacial MP:0005382 10.05 CTNNB1 EXT1 HEY1 MDM2 PTHLH RB1
12 nervous system MP:0003631 10.01 CTNNB1 EXT1 HEY1 MDM2 PTHLH RB1
13 neoplasm MP:0002006 9.98 CDK4 CDKN2A CTNNB1 EXT1 IDH2 MDM2
14 muscle MP:0005369 9.93 CDK4 CDKN2A CTNNB1 HEY1 MDM2 RB1
15 limbs/digits/tail MP:0005371 9.89 CTNNB1 EXT1 MDM2 PTHLH RB1
16 no phenotypic analysis MP:0003012 9.85 EXT1 MDM2 NCOA2 RB1 CDKN2A CTNNB1
17 normal MP:0002873 9.8 EXT1 HEY1 MDM2 RB1 CDK4 CTNNB1
18 reproductive system MP:0005389 9.7 CDK4 CDKN2A CTNNB1 MDM2 NCOA2 PTHLH
19 pigmentation MP:0001186 9.65 CDK4 CDKN2A CTNNB1 MDM2 RB1
20 skeleton MP:0005390 9.5 CDKN2A CTNNB1 EXT1 IDH1 MDM2 PTHLH
21 vision/eye MP:0005391 9.1 CDK4 CDKN2A CTNNB1 EXT1 PTHLH RB1

Drugs & Therapeutics for Periosteal Chondrosarcoma

Search Clinical Trials , NIH Clinical Center for Periosteal Chondrosarcoma

Genetic Tests for Periosteal Chondrosarcoma

Anatomical Context for Periosteal Chondrosarcoma

MalaCards organs/tissues related to Periosteal Chondrosarcoma:

39
Bone

Publications for Periosteal Chondrosarcoma

Articles related to Periosteal Chondrosarcoma:

(show all 21)
id Title Authors Year
1
Diagnosis and Outcome of Periosteal Chondrosarcoma in Two Cats. ( 27487347 )
2016
2
Bony metastases following complete resection of periosteal chondrosarcoma. ( 25889026 )
2015
3
Periosteal chondrosarcoma: a histopathological and molecular analysis of a rare chondrosarcoma subtype. ( 25648524 )
2015
4
Usefulness of PET/CT for diagnosis of periosteal chondrosarcoma of the femur: A case report. ( 24932240 )
2014
5
The presentation, treatment and outcome of periosteal chondrosarcoma in the Netherlands. ( 24891585 )
2014
6
IDH1 mutations are not found in cartilaginous tumours other than central and periosteal chondrosarcomas and enchondromas. ( 22074484 )
2012
7
Periosteal chondrosarcoma of metacarpal bone: Report of a rare entity. ( 23289049 )
2012
8
Periosteal chondrosarcoma of the foot: a case report. ( 20576447 )
2010
9
Periosteal chondrosarcoma. ( 19098166 )
2009
10
Periosteal chondrosarcoma with microscopic cortical invasion. ( 18696199 )
2008
11
Survivorship analysis in patients with periosteal chondrosarcoma. ( 16826117 )
2006
12
Periosteal chondrosarcoma in a 9-year-old girl with osteochondromatosis. ( 15723209 )
2005
13
Periosteal chondrosarcoma. ( 12938935 )
2003
14
Periosteal chondrosarcoma. ( 12195911 )
2002
15
DNA ploidy alterations detected during dedifferentiation of periosteal chondrosarcoma. ( 10472345 )
1999
16
Periosteal chondrosarcoma: a case report and review of the literature. ( 9111097 )
1997
17
Periosteal chondrosarcoma invading the medullary cavity. ( 9229422 )
1997
18
Juxtacortical dedifferentiated chondrosarcoma from a primary periosteal chondrosarcoma. ( 8685228 )
1996
19
MR appearance of periosteal chondrosarcoma of the foot. ( 7822524 )
1995
20
Periosteal chondroma and periosteal chondrosarcoma. ( 4051099 )
1985
21
Periosteal chondrosarcoma and periosteal osteosarcoma. Two distinct entities. ( 7096408 )
1982

Variations for Periosteal Chondrosarcoma

Expression for Periosteal Chondrosarcoma

Search GEO for disease gene expression data for Periosteal Chondrosarcoma.

Pathways for Periosteal Chondrosarcoma

Pathways related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

(show all 29)
id Super pathways Score Top Affiliating Genes
1 12.48 CDK4 CTNNB1 HEY1 MDM2 RB1
2
Show member pathways
12.4 CDK4 CDKN2A MDM2 RB1
3 12.36 CDK4 CDKN2A CTNNB1 MDM2 RB1
4 12.32 CDK4 CDKN2A MDM2 RB1
5
Show member pathways
12.31 CDK4 CDKN2A CTNNB1 HEY1 MDM2 RB1
6 12.25 CDK4 CDKN2A CTNNB1 RB1
7
Show member pathways
12.19 CDK4 CDKN2A MDM2 RB1
8 12.17 CDK4 CDKN2A MDM2 RB1
9 12.1 CDK4 CDKN2A MDM2 RB1
10
Show member pathways
12.09 CDK4 MDM2 RB1
11
Show member pathways
12.06 CDK4 CDKN2A RB1
12
Show member pathways
11.96 CTNNB1 MDM2 NCOA2
13 11.92 CDK4 CDKN2A MDM2
14 11.91 CTNNB1 NCOA2 RB1
15 11.89 CDK4 CTNNB1 MDM2 RB1
16 11.85 CTNNB1 MDM2 NCOA2
17 11.84 CDKN2A CTNNB1 MDM2
18 11.82 CDKN2A CTNNB1 MDM2 RB1
19 11.79 CDKN2A MDM2 RB1
20 11.69 CDK4 MDM2 RB1
21 11.42 CTNNB1 MDM2 NCOA2 RB1
22 11.3 CDK4 MDM2 RB1
23 11.12 CDK4 CDKN2A MDM2 RB1
24 11.07 CDK4 CDKN2A CTNNB1 MDM2 RB1
25 11.03 NCOA2 RB1
26 11 CDK4 CDKN2A MDM2
27
Show member pathways
10.97 CDKN2A MDM2
28 10.78 CDKN2A MDM2 RB1
29
Show member pathways
10.71 IDH1 IDH2

GO Terms for Periosteal Chondrosarcoma

Cellular components related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.23 CDK4 CDKN2A CTNNB1 HEY1 MDM2 NCOA2
2 transcription factor complex GO:0005667 9.13 CDK4 CTNNB1 RB1

Biological processes related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.95 CDKN2A CTNNB1 HEY1 NCOA2 RB1
2 positive regulation of cell proliferation GO:0008284 9.86 CDK4 CTNNB1 MDM2 PTHLH
3 negative regulation of transcription from RNA polymerase II promoter GO:0000122 9.83 CTNNB1 HEY1 MDM2 NCOA2 RB1
4 negative regulation of cell proliferation GO:0008285 9.81 CDKN2A CTNNB1 PTHLH RB1
5 negative regulation of gene expression GO:0010629 9.75 CTNNB1 MDM2 RB1
6 skeletal system development GO:0001501 9.7 CTNNB1 EXT1 PTHLH
7 response to steroid hormone GO:0048545 9.58 IDH1 MDM2
8 G1/S transition of mitotic cell cycle GO:0000082 9.58 CDK4 CDKN2A RB1
9 tricarboxylic acid cycle GO:0006099 9.57 IDH1 IDH2
10 negative regulation of cell cycle arrest GO:0071157 9.54 CDK4 MDM2
11 2-oxoglutarate metabolic process GO:0006103 9.49 IDH1 IDH2
12 negative regulation of chondrocyte differentiation GO:0032331 9.48 CTNNB1 PTHLH
13 endocardial cushion morphogenesis GO:0003203 9.46 HEY1 MDM2
14 regulation of gene expression GO:0010468 9.46 CDK4 CTNNB1 MDM2 PTHLH
15 cardiac septum morphogenesis GO:0060411 9.37 HEY1 MDM2
16 isocitrate metabolic process GO:0006102 9.26 IDH1 IDH2
17 negative regulation of transcription, DNA-templated GO:0045892 9.1 CDKN2A CTNNB1 HEY1 MDM2 NCOA2 RB1
18 amyloid fibril formation GO:1990000 9.02 MDM2
19 glyoxylate cycle GO:0006097 8.96 IDH1 IDH2

Molecular functions related to Periosteal Chondrosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.4 IDH1 IDH2
2 nuclear hormone receptor binding GO:0035257 9.37 CTNNB1 NCOA2
3 transcription factor binding GO:0008134 9.35 CDKN2A CTNNB1 HEY1 NCOA2 RB1
4 SUMO transferase activity GO:0019789 9.32 CDKN2A MDM2
5 isocitrate dehydrogenase (NADP+) activity GO:0004450 9.26 IDH1 IDH2
6 isocitrate dehydrogenase activity GO:0004448 9.16 IDH1 IDH2
7 disordered domain specific binding GO:0097718 8.8 CTNNB1 MDM2 RB1

Sources for Periosteal Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....