MCID: PRS037
MIFTS: 51

Periostitis malady

Summaries for Periostitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Periostitis, also known as periostalgia, is a medical condition caused by inflammation of the... more...

MalaCards: Periostitis is related to chondrosarcoma and osteomyelitis. An important gene associated with Periostitis is IDH1 (isocitrate dehydrogenase 1 (NADP+), soluble), and among its related pathways are 2-Oxocarboxylic acid metabolism and Osteoclast Signaling. The compounds estrogen and procollagen have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and endothelial, and related mouse phenotypes are limbs/digits/tail and craniofacial.

Aliases & Classifications for Periostitis

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 34MeSH, 25ICD10
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Related Diseases for Periostitis

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17GeneCards, 18GeneDecks
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Diseases related to Periostitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 186)
idRelated DiseaseScoreTop Affiliating Genes
1chondrosarcoma30.7BMP2, MMP13
2osteomyelitis30.7IBSP, BMP2
3osteosarcoma30.4IBSP, PDGFB, TNFRSF11A, BMP2, BMP4, IL11
4gingivitis30.3MMP13, ALPP
5arthritis30.3COL2A1, TNFRSF11A, BMP2, GDF5, MMP13, ALPP
6sarcoma30.3PDGFB, BMP2, BMP4
7osteosclerosis30.1ALPP, PTH, BMP2
8secondary syphilis30.0IBSP, TNFRSF11A, BMP2, BMP4, IL11, PTH
9myelofibrosis29.9IL11
10osteonecrosis29.9ALPP, BMP2
11osteitis fibrosa29.9ALPP, PTH
12renal osteodystrophy29.9PTH, ALPP
13rheumatoid arthritis29.9COL2A1, IBSP, TNFRSF11A, BMP2, IL11, MMP13
14periodontal disease29.7ALPP
15inflammatory bowel disease29.7ALPP
16hepatitis29.7ALPP, PDGFB
17liver cirrhosis29.7IL11, PDGFB
18hypercalcemia29.7TNFRSF11A, PTH, ALPP, TGIF1
19cleft palate29.7COL2A1, BMP2, BMP4
20sarcoidosis29.7PDGFB, ALPP, TGIF1
21meningioma29.7TGIF1, PDGFB, HSD17B13
22breast cancer29.7HSD17B13, IBSP, BMP2, MMP13, SRD5A1, TGIF1
23tuberculosis29.7IL11, PDGFB
24osteoarthritis29.7COL2A1, IBSP, TNFRSF11A, BMP2, BMP4, MATN3
25leukemia29.7HSD17B13, IDH1, IDH2, PDGFB, BMP2, BMP4
26chondroma10.7
27periosteal chondrosarcoma10.5
28osteoblastoma10.4
29syphilis10.3
30orbital periostitis10.2
31periosteal osteogenic sarcoma10.2
32alveolar periostitis10.2
33juxtacortical chondroma10.2
34polyarteritis nodosa10.2
35hyperostosis10.2
36typhoid fever10.1
37congenital syphilis10.1
38keratitis10.1
39myositis10.1
40crohn's disease10.1
41gingival recession10.1
42juxtacortical chondrosarcoma10.1
43osteochondritis dissecans10.1
44bone osteosarcoma10.1
45cervicitis10.1
46fasciitis10.1
47interstitial keratitis10.1
48vasculitis10.1
49prostatitis10.0SRD5A1
50metaphyseal dysplasia10.0COL2A1

Graphical network of the top 20 diseases related to Periostitis:



Diseases related to periostitis

Clinical Features for Periostitis

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Drugs & Therapeutics for Periostitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Periostitis

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Anatomical Context for Periostitis

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32MalaCards
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MalaCards organs/tissues related to Periostitis:

32
Bone, Lung, Endothelial, Testes, Heart, Liver, Brain, Bone marrow, Breast

Animal Models for Periostitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Periostitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.1GDF5, MATN3, BMP4, COL2A1, KL
2MP:00053829.9TNFRSF11A, BMP2, BMP4, PTH, TGIF1, COL2A1
3MP:00053909.7KL, COL2A1, IBSP, TNFRSF11A, BMP2, MATN3
4MP:00053899.6KL, TNFRSF11A, BMP2, BMP4, GDF5, SRD5A1
5MP:00053859.2KL, COL2A1, PDGFB, BMP2, BMP4, NT5E
6MP:00053789.2TNFRSF11A, PDGFB, IBSP, COL2A1, KL, BMP2

Publications for Periostitis

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50PubMed
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Articles related to Periostitis:

(show top 50)    (show all 408)
idTitleAuthorsYear
1
Periostitis in a patient with inflammatory bowel disease. (23118281)
2012
2
A new skill for treating unclassified thumb polydactyly: ablation via a periosteal incision. (22476516)
2012
3
Medication-induced periostitis in lung transplant patients: periostitis deformans revisited. (20652242)
2011
4
A report of a rare phalangeal periosteal chondroma of the foot. (21172646)
2011
5
Periosteal chondroma of the pediatric cervical spine. (19278317)
2009
6
Periostitis and hypertrophic pulmonary osteoarthropathy: report of 2 cases and review of the literature. (18760449)
2009
7
Periosteal pedicle graft for the treatment of gingival recession defects: a novel technique. (19709114)
2009
8
Combined encephaloduroarteriosynangiosis and bifrontal encephalogaleo (periosteal) synangiosis in pediatric moyamoya disease. (18695565)
2008
9
Barium periostitis: an intraoral complication following barium swallow. (17317236)
2007
10
Periosteal osteoblastoma: report of a case with a rare histopathologic presentation and review of the literature. (16868789)
2007
11
A periosteal chondroma in the lumbar spinal canal. Case report. (17933323)
2007
12
Tumor induced by Moloney sarcoma virus causes periosteal osteogenesis engaging osteopontin, fibronectin, stromelysin-1 and tenascin. (17319793)
2007
13
Childhood onset of psoriatic onycho-pachydermo-periostitis (POPP). (16268902)
2005
14
Case number 34: Relapse of polyarteritis nodosa presenting as isolated and localised lower limb periostitis. (16014679)
2005
15
Gene-enhanced tissue engineering: applications for bone healing using cultured periosteal cells transduced retrovirally with the BMP-7 gene. (10340856)
1999
16
Osteochondritis dissecans of the femoral condyle treated with periosteal transplantation. Poor outcome in 14 patients followed for 6-9 years. (9930104)
1998
17
Periosteal osteoblastoma of the distal humerus. (9811987)
1998
18
Pitcher's periostitis. A case report. (9548129)
1998
19
Periosteal chondroma of the clavicle. (8738012)
1996
20
Periosteal chondroma developing in a rib at the side of a chest wall wound from a previous thoracotomy: report of a case. (8680124)
1996
21
Stimulation of PGE2 synthesis in a co-culture of periosteal fibroblasts and osteoblast-like cells by parathyroid hormone. (8358022)
1993
22
Rearrangement of band q13 on both chromosomes 12 in a periosteal chondroma. (7680888)
1993
23
Interleukin-1 alpha and epidermal growth factor synergistically enhance the release of collagenase by periosteal connective tissue in vitro. (8246834)
1993
24
Scintigraphic diagnosis of costal periostitis in actinomycosis. (1638850)
1992
25
Phalangeal periosteal (juxtacortical)chondroma of the foot. (1430837)
1992
26
Periostitis in hypertrophic osteoarthropathy: relationship to disease duration. (3493663)
1987
27
Orbital cellulitis with periosteal elevation. (3154568)
1987
28
Periosteal chondroma with atypical behavior in a 9-year-old black female: case report. (3960774)
1986
29
Pain and periostitis. (4045899)
1985
30
Case report 304. Florid reactive periostitis proximal phalange of the left 5th finger. (3975663)
1985
31
Periosteal chondroma of the humerus leading to shortening. A case report. (3980543)
1985
32
Periosteal chondroma: another cause of carpal tunnel syndrome. (6721390)
1984
33
Periosteal osteogenic sarcoma of the mandible. (6588346)
1984
34
Traumatic distal femoral periostitis of the newborn: a breech delivery birth injury. (6644835)
1983
35
Periosteal chondroma. (7112178)
1982
36
Periosteal chondroma: a radiographic spectrum. (6936836)
1981
37
Proliferative periostitis of GarrAc: its differentiation from other neoperiostoses. (289735)
1979
38
Periosteal benign osteoblastoma of the mandible. Report of a case and review of the literature pertaining to benign osteoblastic neoplasms of the jaws. (1066151)
1976
39
Chronic mandibular periostitis associated with "vasculitis". (59336)
1975
40
Periostitis associated with diabetic ulcer. (5769688)
1969
41
Idiopathic periostitis with hypercalcemia. (6024239)
1967
42
Electron microscopic study of periosteal hyperostosis in rats with lathyrism induced by aminoacetonitrile. (5234345)
1966
43
Radiological aspects of a new type of bone fluorosis, periostitis deformans. (5926232)
1966
44
Chronic polyostotic periostitis of unknown etiology. (14036714)
1961
45
Periosteal reaction with osseous neoplasm revealing periarteritis nodosa (13750319)
1961
46
Periosteal osteogenic sarcoma of the right femur following trauma; case report. (18875622)
1948
47
Periostitis, osteitis and osteomyelitis. (21017030)
1946
48
Case ofA ? Periostitis of Metatarsal. (20910453)
1927
49
Interstitial Keratitis and Osteo-periostitis of the Tibiae treated with Neo-salvarsan. (19977326)
1913
50
Periostitis following Typhoid Fever. (20751182)
1885

Genetic Variations for Periostitis

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Expression for genes affiliated with Periostitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Periostitis

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Pathways for genes affiliated with Periostitis

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29KEGG, 37NCBI BioSystems Database, 53Reactome, 55SinoBiological, 12EMD Millipore, 51QIAGEN
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Pathways related to Periostitis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3IDH2, IDH1
210.3PDGFB, TNFRSF11A
310.2PTH, PDGFB, IBSP
410.2GDF5, BMP4, BMP2
5
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10.2GDF5, BMP4, BMP2
610.2BMP2, BMP4, GDF5
710.2COL2A1, MMP13, PTH
810.1MIA, BMP4, COL2A1
9
Development Hedgehog and PTH signaling pathways in bone and cartilage development
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10.1COL2A1, IBSP, MMP13, PTH
10
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10.1GDF5, BMP4, BMP2, PDGFB
11
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10.0MMP13, GDF5, BMP4, BMP2, PDGFB
12
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10.0GDF5, BMP4, BMP2, PDGFB, COL2A1
13
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10.0PDGFB, BMP2, BMP4, GDF5, IL11
14
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9.9GDF5, BMP4, BMP2, TNFRSF11A, PDGFB, IL11
15
Hide members
9.9PDGFB, TNFRSF11A, BMP2, BMP4, GDF5, IL11
16
Hide members
9.9PDGFB, TNFRSF11A, BMP2, BMP4, GDF5, IL11
17
Hide members
9.8MMP13, GDF5, MATN3, BMP4, BMP2, PDGFB
18
Hide members
9.8COL2A1, PDGFB, TNFRSF11A, BMP2, BMP4, GDF5

Compounds for genes affiliated with Periostitis

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Periostitis according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8SRD5A1
2procollagen4410.7COL2A1, ALPP
3deoxypyridinoline4410.5IBSP, IL11, PTH
4estradiol44 11 2412.5HSD17B13, IBSP, SRD5A1
5alizarin4410.5IBSP, BMP2, ALPP
6forskolin44 49 1112.5PTH, IL11, IBSP
7chitosan4410.5ALPP, BMP2, IBSP
8pyridinoline4410.4COL2A1, IBSP, ALPP
9zoledronic acid4410.4IBSP, BMP2, ALPP
10retinoid4410.4TGIF1, ALPP, MMP13, HSD17B13
11glycosaminoglycan4410.4MMP13, GDF5, BMP2, IBSP, COL2A1
12cycloheximide4410.4COL2A1, IBSP, PDGFB, PTH, ALPP
13prostaglandin4410.4TNFRSF11A, IL11, PTH, TGIF1
14hydroxyproline44 11 2412.4COL2A1, IBSP, MMP13, PTH, ALPP
15titanium4410.3IBSP, BMP2, BMP4, IL11, ALPP
16alendronate44 49 1112.3BMP2, IL11, MMP13, PTH, ALPP
17azathioprine44 49 2 1113.3IL11, BMP4, BMP2, PDGFB
18heparin44 28 11 2413.3IBSP, BMP2, IL11, MMP13, TGIF1
19alginate4410.3MMP13, BMP2, COL2A1
20ibmx44 28 5912.3IBSP, BMP2, PTH, ALPP
21tgf beta14410.2PDGFB, BMP2, BMP4, IL11, MMP13, TGIF1
22pd 98,0594410.2IBSP, PDGFB, BMP2, BMP4, MMP13, ALPP
23fibroin4410.2IBSP, BMP2
24hydroxyapatite4410.2IBSP, TNFRSF11A, BMP2, IL11, MMP13, ALPP
25dihydrotestosterone44 28 11 2413.2HSD17B13, BMP2, SRD5A1, TGIF1
261,25 dihydroxy vitamin d34410.1IBSP, TNFRSF11A, BMP2, IL11, PTH, ALPP
27serine4410.1COL2A1, HSD17B13, PDGFB, TNFRSF11A, BMP2, MMP13
28progestins4410.1TGIF1, SRD5A1, HSD17B13
29creatinine4410.1HSD17B13, IBSP, BMP2, PTH, ALPP, TGIF1
30cyclic amp44 2411.1TGIF1, PTH, MMP13, IL11, NT5E, IBSP
31dexamethasone44 49 28 1113.1COL2A1, IBSP, PDGFB, BMP2, MMP13, PTH
32calcitriol44 59 11 2413.1TNFRSF11A, BMP2, IL11, SRD5A1, PTH, ALPP
33ribonucleic acid4410.1HSD17B13, PDGFB, BMP2, BMP4, IL11, MMP13
34ascorbic acid44 2411.0COL2A1, HSD17B13, IBSP, BMP2, BMP4, MMP13
35oligonucleotide4410.0COL2A1, IBSP, PDGFB, BMP2, BMP4, IL11
36progesterone44 59 28 11 2414.0HSD17B13, PDGFB, BMP2, BMP4, IL11, SRD5A1
37steroid4410.0HSD17B13, IBSP, BMP2, BMP4, IL11, SRD5A1
38vitamin d4410.0COL2A1, IBSP, BMP2, IL11, SRD5A1, PTH
39genistein44 28 59 2 11 2415.0BMP2, MMP13, SRD5A1, ALPP, TGIF1
40oxygen44 2411.0COL2A1, PDGFB, TNFRSF11A, BMP2, IL11, MMP13
41thymidine44 2411.0IBSP, PDGFB, BMP2, BMP4, IL11, MMP13
42testosterone44 59 11 2412.9HSD17B13, BMP2, SRD5A1, PTH, ALPP, TGIF1
43nitric oxide44 11 2411.9COL2A1, PDGFB, TNFRSF11A, BMP2, BMP4, IL11
44cysteine449.9COL2A1, IBSP, BMP2, BMP4, GDF5, IL11
45cyclosporin a44 28 5911.9ALPP, IL11, BMP4, BMP2, PDGFB
46retinoic acid44 2410.9COL2A1, BMP2, BMP4, IL11, MMP13, SRD5A1
47dehydroepiandrosterone sulfate449.8PTH, SRD5A1, HSD17B13
48tyrosine449.7KL, IBSP, PDGFB, TNFRSF11A, BMP2, BMP4
49vegf449.5TGIF1, KL, IBSP, PDGFB, TNFRSF11A, BMP2
50calcium44 49 11 2412.4BMP2, TNFRSF11A, IDH1, IBSP, COL2A1, KL

GO Terms for genes affiliated with Periostitis

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16Gene Ontology
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Cellular components related to Periostitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.4COL2A1, PDGFB, BMP2, BMP4, MIA, GDF5
2extracellular regionGO:0055769.0PTH, KL, COL2A1, HSD17B13, IBSP, PDGFB

Biological processes related to Periostitis according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1glyoxylate cycleGO:00609710.7IDH1, IDH2
2isocitrate metabolic processGO:00610210.6IDH1, IDH2
3mesenchymal cell proliferation involved in ureteric bud developmentGO:07213810.6BMP2, BMP4
4BMP signaling pathway involved in heart inductionGO:00313010.6BMP2, BMP4
5telencephalon regionalizationGO:02197810.6BMP4, BMP2
6regulation of odontogenesis of dentin-containing toothGO:04248710.6BMP4, BMP2
7cellular response to growth factor stimulusGO:07136310.5IBSP, PDGFB, BMP4
8chondrocyte differentiationGO:00206210.5BMP4, BMP2, COL2A1
9proteoglycan metabolic processGO:00602910.5BMP2, COL2A1
10positive regulation of endothelial cell proliferationGO:00193810.5BMP4, BMP2, PDGFB
11positive regulation of cartilage developmentGO:06103610.5BMP2, BMP4
12cartilage developmentGO:05121610.5COL2A1, GDF5, MMP13
13positive regulation of ossificationGO:04577810.4BMP2, BMP4
14skeletal system developmentGO:00150110.4COL2A1, BMP2, MATN3, PTH
15positive regulation of bone mineralizationGO:03050110.4KL, BMP2, BMP4, PTH
16positive regulation of MAPK cascadeGO:04341010.4PDGFB, BMP2, IL11
17embryonic skeletal joint morphogenesisGO:06027210.4BMP4, COL2A1
18positive regulation of neuron differentiationGO:04566610.4BMP2, BMP4, TGIF1
19cellular response to BMP stimulusGO:07177310.3COL2A1, BMP2
20cell-cell signalingGO:00726710.3PTH, IL11, GDF5, BMP2, TNFRSF11A
212-oxoglutarate metabolic processGO:00610310.3IDH1, IDH2
22positive regulation of ERK1 and ERK2 cascadeGO:07037410.3PDGFB, BMP2, BMP4
23SMAD protein signal transductionGO:06039510.3BMP4, BMP2
24monocyte chemotaxisGO:00254810.2PDGFB, TNFRSF11A
25extracellular matrix organizationGO:03019810.1MMP13, COL2A1, IBSP, PDGFB, BMP2, BMP4
26telencephalon developmentGO:02153710.0BMP4, BMP2

Molecular functions related to Periostitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1isocitrate dehydrogenase (NADP+) activityGO:00445010.3IDH2, IDH1
2platelet-derived growth factor bindingGO:04840710.3PDGFB, COL2A1
3BMP receptor bindingGO:07070010.0BMP4, BMP2
4cytokine activityGO:00512510.0BMP2, BMP4, GDF5, IL11
5growth factor activityGO:0080839.9IL11, PDGFB, BMP2, BMP4, MIA, GDF5

Products for genes affiliated with Periostitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Periostitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet