MCID: PRS037
MIFTS: 51

Periostitis malady

Summaries for Periostitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Periostitis, also known as periostalgia, is a medical condition caused by inflammation of the... more...

MalaCards: Periostitis is related to chondrosarcoma and osteomyelitis. An important gene associated with Periostitis is IDH1 (isocitrate dehydrogenase 1 (NADP+), soluble), and among its related pathways are 2-Oxocarboxylic acid metabolism and Osteoclast Signaling. The compounds estrogen and procollagen have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and endothelial, and related mouse phenotypes are limbs/digits/tail and craniofacial.

Aliases & Classifications for Periostitis

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 34MeSH, 25ICD10
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Related Diseases for Periostitis

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17GeneCards, 18GeneDecks
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Diseases related to Periostitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 186)
idRelated DiseaseScoreTop Affiliating Genes
1chondrosarcoma30.7BMP2, MMP13
2osteomyelitis30.7IBSP, BMP2
3osteosarcoma30.4IBSP, PDGFB, TNFRSF11A, BMP2, BMP4, IL11
4gingivitis30.3MMP13, ALPP
5arthritis30.3COL2A1, TNFRSF11A, BMP2, GDF5, MMP13, ALPP
6sarcoma30.3PDGFB, BMP2, BMP4
7osteosclerosis30.1ALPP, PTH, BMP2
8secondary syphilis30.0IBSP, TNFRSF11A, BMP2, BMP4, IL11, PTH
9myelofibrosis29.9IL11
10osteonecrosis29.9ALPP, BMP2
11osteitis fibrosa29.9ALPP, PTH
12renal osteodystrophy29.9PTH, ALPP
13rheumatoid arthritis29.9COL2A1, IBSP, TNFRSF11A, BMP2, IL11, MMP13
14periodontal disease29.7ALPP
15inflammatory bowel disease29.7ALPP
16hepatitis29.7ALPP, PDGFB
17liver cirrhosis29.7IL11, PDGFB
18hypercalcemia29.7TNFRSF11A, PTH, ALPP, TGIF1
19cleft palate29.7COL2A1, BMP2, BMP4
20sarcoidosis29.7PDGFB, ALPP, TGIF1
21meningioma29.7TGIF1, PDGFB, HSD17B13
22breast cancer29.7HSD17B13, IBSP, BMP2, MMP13, SRD5A1, TGIF1
23tuberculosis29.7IL11, PDGFB
24osteoarthritis29.7COL2A1, IBSP, TNFRSF11A, BMP2, BMP4, MATN3
25leukemia29.7HSD17B13, IDH1, IDH2, PDGFB, BMP2, BMP4
26chondroma10.7
27periosteal chondrosarcoma10.5
28osteoblastoma10.4
29syphilis10.3
30orbital periostitis10.2
31periosteal osteogenic sarcoma10.2
32alveolar periostitis10.2
33juxtacortical chondroma10.2
34polyarteritis nodosa10.2
35hyperostosis10.2
36typhoid fever10.1
37congenital syphilis10.1
38keratitis10.1
39myositis10.1
40crohn's disease10.1
41gingival recession10.1
42juxtacortical chondrosarcoma10.1
43osteochondritis dissecans10.1
44bone osteosarcoma10.1
45cervicitis10.1
46fasciitis10.1
47interstitial keratitis10.1
48vasculitis10.1
49prostatitis10.0SRD5A1
50metaphyseal dysplasia10.0COL2A1

Graphical network of the top 20 diseases related to Periostitis:



Diseases related to periostitis

Clinical Features for Periostitis

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Drugs & Therapeutics for Periostitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Periostitis

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Anatomical Context for Periostitis

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32MalaCards
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MalaCards organs/tissues related to Periostitis:

32
Bone, Lung, Endothelial, Heart, Testes, Bone marrow, Brain, Liver, Breast

Animal Models for Periostitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Periostitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.1GDF5, MATN3, BMP4, COL2A1, KL
2MP:00053829.9TNFRSF11A, BMP2, BMP4, PTH, TGIF1, COL2A1
3MP:00053909.7KL, COL2A1, IBSP, TNFRSF11A, BMP2, MATN3
4MP:00053899.6KL, TNFRSF11A, BMP2, BMP4, GDF5, SRD5A1
5MP:00053859.2KL, COL2A1, PDGFB, BMP2, BMP4, NT5E
6MP:00053789.2TNFRSF11A, PDGFB, IBSP, COL2A1, KL, BMP2

Publications for Periostitis

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50PubMed
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Articles related to Periostitis:

(show top 50)    (show all 408)
idTitleAuthorsYear
1
Multifocal periostitis as a complication of chronic use of voriconazole in a lung transplant recipient. (23663268)
2013
2
(99m)Tc-MDP- and (18F)-FDG-avid florid reactive periostitis ossificans mimicking recurrent osteosarcoma. (23603597)
2013
3
Loss of I^-catenin induces multifocal periosteal chondroma-like masses in mice. (23274133)
2013
4
Hemodynamic improvement of anterior cerebral artery territory perfusion induced by bifrontal encephalo(periosteal) synangiosis in pediatric patients with moyamoya disease: a study with brain perfusion SPECT. (22033781)
2012
5
Psoriatic onycho-pachydermo-periostitis progressing to generalized pustular psoriasis. (22816987)
2012
6
Multifocal nodular periostitis associated with prolonged voriconazole therapy in a lung transplant recipient. (21169844)
2011
7
Fluoride excess and periostitis in transplant patients receiving long-term voriconazole therapy. (21239842)
2011
8
Chondrosarcoma of the femur with histology-imaging correlation of tumor growth--preliminary observations concerning periosteal new bone formation and soft tissue extension. (22035395)
2011
9
Periostitis secondary to prolonged voriconazole therapy in a lung transplant recipient. (22049971)
2011
10
Periosteal chondrosarcoma of the foot: a case report. (20576447)
2010
11
Coculture between periosteal explants and articular chondrocytes induces expression of TGF-beta1 and collagen I. (19952089)
2010
12
Periosteal chondroma of the clavicle: case report and review of the literature. (19185557)
2009
13
Periosteal osteoblastoma of the calvaria mimicking a meningioma. (18359169)
2008
14
Differential response of psoriatic onycho-pachydermo-periostitis to 2 anti-tumor necrosis factor-alpha agents. (18843767)
2008
15
Solitary periosteal chondroma presenting as a snapping finger: an unusual location. (19054834)
2008
16
A biomarker-based mathematical model to predict bone-forming potency of human synovial and periosteal mesenchymal stem cells. (18163504)
2008
17
Optic neuropathy associated with periostitis in relapsing polychondritis. (17414867)
2007
18
FGF2 effects in periosteal fibroblasts bearing the FGFR2 receptor Pro253 Arg mutation. (17537644)
2007
19
Concurrent periosteal chondroma and enchondroma of the fibula mimicking chondrosarcoma. (16421751)
2006
20
Osteomyelitis with proliferative periostitis: an unusual case. (17052617)
2006
21
Prevention of postoperative meatal stenosis with anteriorly and inferiorly based periosteal flaps in congenital aural atresia surgery. (11773841)
2002
22
Kissing periosteal chondroma and osteochondroma. (11904693)
2002
23
Severe toxic osteoblastoma of the humerus associated with diffuse periostitis of multiple bones. (11479753)
2001
24
Isolation of a cDNA sequence of rabbit GDF5 (mature form) and pattern of its mRNA expression during periosteal chondrogenesis. (11252805)
2000
25
Takayasu's arteritis presenting with focal periostitis affecting two limbs. (9894711)
1998
26
Periosteal chondrosarcoma: a case report and review of the literature. (9111097)
1997
27
Traumatic ossifying periostitis of the ulna masquerading as a malignancy in a football player. A case report and literature review. (8947411)
1996
28
Radiology case of the month. Digital clubbing, arthritis, and symmetric periostitis. Secondary hypertrophic osteoarthropathy (Marie-Bamberger syndrome). (8936939)
1996
29
Juxtacortical dedifferentiated chondrosarcoma from a primary periosteal chondrosarcoma. (8685228)
1996
30
MR appearance of periosteal chondrosarcoma of the foot. (7822524)
1995
31
Florid reactive periostitis. (7592279)
1995
32
Time-dependent effects of parathyroid hormone and prostaglandin E2 on DNA synthesis by periosteal cells from embryonic chick calvaria. (7987735)
1994
33
Periosteal chondroma masquerading as osteochondroma. (8504334)
1993
34
Case report 518: Periosteal chondroma of scapula. (2711209)
1989
35
Periosteal chondroma of the cervical spine: one more cause of neural foramen enlargement. (3336850)
1988
36
Two cases of periosteal chondroma. (3213465)
1988
37
Proliferative periostitis (GarrAc's osteomyelitis). (3469611)
1987
38
Florid reactive periostitis of the proximal phalanx. Case report. (4019546)
1985
39
Periostitis in secondary syphilis: a place for bone scintigraphy. (4045902)
1985
40
Periosteal chondroma. A review of twenty cases. (6822582)
1983
41
Periosteal chondroma. A clinicopathologic study of 23 cases. (7180962)
1982
42
Prostaglandin-induced periostitis: a complication of long-term PGE1 infusion in an infant with congenital heart disease. (7199748)
1982
43
Quantitative scintigraphy in diagnosis and management of plantar fasciitis (calcaneal periostitis): concise communication. (7391835)
1980
44
Epidemiology of odontogenic periostitis. (6769830)
1980
45
Benign osteoblastoma of the maxilla (periosteal). (641417)
1978
46
Periostitis ossificans. (4509984)
1972
47
Recurrent periosteal chondroma. Report of two cases and a review of the literature. (5767327)
1969
48
Traumatic periostitis and subdural hematoma. (13383832)
1956
49
Traumatic Periostitis. (19993620)
1947
50
Acute Infectious Osteomyelitis and Periostitis. (17857400)
1889

Genetic Variations for Periostitis

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Expression for genes affiliated with Periostitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Periostitis

Search GEO for disease gene expression data for Periostitis.

Pathways for genes affiliated with Periostitis

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29KEGG, 37NCBI BioSystems Database, 53Reactome, 55SinoBiological, 12EMD Millipore, 51QIAGEN
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Pathways related to Periostitis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3IDH2, IDH1
210.3PDGFB, TNFRSF11A
310.2PTH, PDGFB, IBSP
410.2GDF5, BMP4, BMP2
5
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10.2GDF5, BMP4, BMP2
610.2BMP2, BMP4, GDF5
710.2COL2A1, MMP13, PTH
810.1MIA, BMP4, COL2A1
9
Development Hedgehog and PTH signaling pathways in bone and cartilage development
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10.1COL2A1, IBSP, MMP13, PTH
10
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10.1GDF5, BMP4, BMP2, PDGFB
11
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10.0MMP13, GDF5, BMP4, BMP2, PDGFB
12
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10.0GDF5, BMP4, BMP2, PDGFB, COL2A1
13
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10.0PDGFB, BMP2, BMP4, GDF5, IL11
14
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9.9GDF5, BMP4, BMP2, TNFRSF11A, PDGFB, IL11
15
Hide members
9.9PDGFB, TNFRSF11A, BMP2, BMP4, GDF5, IL11
16
Hide members
9.9PDGFB, TNFRSF11A, BMP2, BMP4, GDF5, IL11
17
Hide members
9.8MMP13, GDF5, MATN3, BMP4, BMP2, PDGFB
18
Hide members
9.8COL2A1, PDGFB, TNFRSF11A, BMP2, BMP4, GDF5

Compounds for genes affiliated with Periostitis

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Periostitis according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8SRD5A1
2procollagen4410.7ALPP, COL2A1
3deoxypyridinoline4410.5IBSP, IL11, PTH
4estradiol44 11 2412.5SRD5A1, IBSP, HSD17B13
5alizarin4410.5IBSP, ALPP, BMP2
6forskolin44 49 1112.5PTH, IL11, IBSP
7chitosan4410.5BMP2, ALPP, IBSP
8pyridinoline4410.4IBSP, COL2A1, ALPP
9zoledronic acid4410.4BMP2, IBSP, ALPP
10retinoid4410.4HSD17B13, MMP13, TGIF1, ALPP
11glycosaminoglycan4410.4COL2A1, MMP13, IBSP, BMP2, GDF5
12cycloheximide4410.4PDGFB, PTH, COL2A1, ALPP, IBSP
13prostaglandin4410.4TGIF1, TNFRSF11A, PTH, IL11
14hydroxyproline44 11 2412.4COL2A1, IBSP, MMP13, PTH, ALPP
15titanium4410.3IL11, BMP4, ALPP, IBSP, BMP2
16alendronate44 49 1112.3BMP2, MMP13, ALPP, IL11, PTH
17azathioprine44 49 2 1113.3PDGFB, BMP2, BMP4, IL11
18heparin44 28 11 2413.3IBSP, IL11, BMP2, MMP13, TGIF1
19alginate4410.3MMP13, COL2A1, BMP2
20ibmx44 28 5912.3IBSP, PTH, ALPP, BMP2
21tgf beta14410.2PDGFB, BMP2, BMP4, IL11, TGIF1, MMP13
22pd 98,0594410.2BMP4, BMP2, MMP13, ALPP, PDGFB, IBSP
23fibroin4410.2IBSP, BMP2
24hydroxyapatite4410.2ALPP, IL11, BMP2, TNFRSF11A, MMP13, IBSP
25dihydrotestosterone44 28 11 2413.2HSD17B13, BMP2, SRD5A1, TGIF1
261,25 dihydroxy vitamin d34410.1ALPP, IBSP, TNFRSF11A, BMP2, PTH, TGIF1
27serine4410.1COL2A1, PDGFB, TNFRSF11A, BMP2, MMP13, ALPP
28phenytoin44 49 28 1113.1SRD5A1, ALPP, PDGFB
29creatinine4410.1PTH, TGIF1, BMP2, IBSP, HSD17B13, ALPP
30cyclic amp44 2411.1NT5E, IBSP, MMP13, IL11, TGIF1, PTH
31dexamethasone44 49 28 1113.1PDGFB, ALPP, PTH, MMP13, BMP2, TGIF1
32calcitriol44 59 11 2413.1ALPP, TGIF1, SRD5A1, IL11, BMP2, TNFRSF11A
33ribonucleic acid4410.1PTH, TGIF1, IL11, BMP4, MMP13, BMP2
34ascorbic acid44 2411.0HSD17B13, ALPP, BMP4, IBSP, MMP13, COL2A1
35oligonucleotide4410.0PDGFB, IBSP, BMP2, COL2A1, IL11, BMP4
36progesterone44 59 28 11 2414.0PDGFB, SRD5A1, IL11, HSD17B13, TGIF1, BMP4
37steroid4410.0BMP2, IBSP, BMP4, IL11, SRD5A1, TGIF1
38vitamin d4410.0SRD5A1, COL2A1, IBSP, BMP2, IL11, TGIF1
39genistein44 28 59 2 11 2415.0MMP13, BMP2, TGIF1, SRD5A1, ALPP
40oxygen44 2411.0BMP2, PDGFB, TGIF1, TNFRSF11A, MMP13, COL2A1
41thymidine44 2411.0ALPP, PTH, MMP13, IL11, BMP4, BMP2
42testosterone44 59 11 2412.9BMP2, SRD5A1, PTH, ALPP, TGIF1, HSD17B13
43nitric oxide44 11 2411.9PTH, MMP13, IL11, BMP4, TNFRSF11A, COL2A1
44cysteine449.9COL2A1, BMP4, GDF5, IL11, BMP2, MMP13
45cyclosporin a44 28 5911.9BMP2, PDGFB, ALPP, IL11, BMP4
46retinoic acid44 2410.9ALPP, TGIF1, IL11, SRD5A1, COL2A1, BMP2
47dehydroepiandrosterone sulfate449.8HSD17B13, SRD5A1, PTH
48tyrosine449.7TNFRSF11A, TGIF1, PTH, IL11, GDF5, PDGFB
49vegf449.5TNFRSF11A, ALPP, PTH, SRD5A1, MMP13, IL11
50calcium44 49 11 2412.4MMP13, KL, COL2A1, IDH1, MATN3, TNFRSF11A

GO Terms for genes affiliated with Periostitis

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16Gene Ontology
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Cellular components related to Periostitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.4COL2A1, PDGFB, BMP2, BMP4, MIA, GDF5
2extracellular regionGO:0055769.0PTH, KL, COL2A1, HSD17B13, IBSP, PDGFB

Biological processes related to Periostitis according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1glyoxylate cycleGO:00609710.7IDH1, IDH2
2isocitrate metabolic processGO:00610210.6IDH1, IDH2
3mesenchymal cell proliferation involved in ureteric bud developmentGO:07213810.6BMP2, BMP4
4BMP signaling pathway involved in heart inductionGO:00313010.6BMP2, BMP4
5telencephalon regionalizationGO:02197810.6BMP4, BMP2
6regulation of odontogenesis of dentin-containing toothGO:04248710.6BMP4, BMP2
7cellular response to growth factor stimulusGO:07136310.5IBSP, PDGFB, BMP4
8chondrocyte differentiationGO:00206210.5BMP4, BMP2, COL2A1
9proteoglycan metabolic processGO:00602910.5BMP2, COL2A1
10positive regulation of endothelial cell proliferationGO:00193810.5BMP4, BMP2, PDGFB
11positive regulation of cartilage developmentGO:06103610.5BMP2, BMP4
12cartilage developmentGO:05121610.5COL2A1, GDF5, MMP13
13positive regulation of ossificationGO:04577810.4BMP2, BMP4
14skeletal system developmentGO:00150110.4COL2A1, BMP2, MATN3, PTH
15positive regulation of bone mineralizationGO:03050110.4KL, BMP2, BMP4, PTH
16positive regulation of MAPK cascadeGO:04341010.4PDGFB, BMP2, IL11
17embryonic skeletal joint morphogenesisGO:06027210.4BMP4, COL2A1
18positive regulation of neuron differentiationGO:04566610.4BMP2, BMP4, TGIF1
19cellular response to BMP stimulusGO:07177310.3COL2A1, BMP2
20cell-cell signalingGO:00726710.3PTH, IL11, GDF5, BMP2, TNFRSF11A
212-oxoglutarate metabolic processGO:00610310.3IDH1, IDH2
22positive regulation of ERK1 and ERK2 cascadeGO:07037410.3PDGFB, BMP2, BMP4
23SMAD protein signal transductionGO:06039510.3BMP4, BMP2
24monocyte chemotaxisGO:00254810.2PDGFB, TNFRSF11A
25extracellular matrix organizationGO:03019810.1MMP13, COL2A1, IBSP, PDGFB, BMP2, BMP4
26telencephalon developmentGO:02153710.0BMP4, BMP2

Molecular functions related to Periostitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1isocitrate dehydrogenase (NADP+) activityGO:00445010.3IDH2, IDH1
2platelet-derived growth factor bindingGO:04840710.3PDGFB, COL2A1
3BMP receptor bindingGO:07070010.0BMP4, BMP2
4cytokine activityGO:00512510.0BMP2, BMP4, GDF5, IL11
5growth factor activityGO:0080839.9IL11, PDGFB, BMP2, BMP4, MIA, GDF5

Products for genes affiliated with Periostitis

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Sources for Periostitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet