MCID: PRS037
MIFTS: 44

Periostitis malady

Summaries for Periostitis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Periostitis, also known as periostalgia, is a medical condition caused by inflammation of the... more...

MalaCards: Periostitis is related to gingivitis and osteosarcoma. An important gene associated with Periostitis is TNFRSF11A (tumor necrosis factor receptor superfamily, member 11a, NFKB activator), and among its related pathways are Apoptosis and survival Anti apoptotic TNFs NF kB Bcl 2 pathway and TRAF Pathway. The compounds denosumab and polyethylene have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and endothelial, and related mouse phenotypes are hematopoietic system and skeleton.

Aliases & Classifications for Periostitis

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9Disease Ontology, 63UMLS, 36MeSH, 59SNOMED-CT, 26ICD10
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Related Diseases for Periostitis

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18GeneCards, 19GeneDecks
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Diseases related to Periostitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1gingivitis30.4ALPP, TNFRSF11B
2osteosarcoma30.3TNFRSF11A, TNFRSF11B, IL11, IL1RN, ALPP
3arthritis30.3TNFRSF11A, TNFRSF11B, IL1RN, ALPP
4osteosclerosis30.2TNFRSF11B, ALPP
5osteitis fibrosa30.1ALPP
6periodontitis30.0IL1RN, TNFRSF11B
7renal osteodystrophy30.0ALPP, TNFRSF11B
8rheumatoid arthritis29.9IL1RN, IL11, TNFRSF11B, TNFRSF11A
9secondary syphilis29.9TNFRSF11A, TNFRSF11B, IL11, ALPP
10inflammatory bowel disease29.8ALPP, IL1RN
11sarcoidosis29.8IL1RN, ALPP
12thrombocytopenia29.7ALPP, IL11
13osteoarthritis29.7TNFRSF11A, TNFRSF11B, IL1RN
14hypercalcemia29.7TNFRSF11A, TNFRSF11B, ALPP
15periodontal disease29.6TNFRSF11A, TNFRSF11B, IL11, IL1RN, ALPP
16breast cancer29.6TNFRSF11A, TNFRSF11B, IL11, ALPP, SQSTM1
17chondroma10.8
18chondrosarcoma10.5
19periosteal chondrosarcoma10.5
20osteomyelitis10.5
21osteoblastoma10.4
22syphilis10.3
23periosteal osteogenic sarcoma10.3
24alveolar periostitis10.2
25sarcoma10.2
26juxtacortical chondroma10.2
27polyarteritis nodosa10.2
28hyperostosis10.2
29orbital periostitis10.2
30typhoid fever10.2
31congenital syphilis10.2
32keratitis10.2
33myositis10.2
34crohn's disease10.1
35gingival recession10.1
36osteochondritis dissecans10.1
37cervicitis10.1
38fasciitis10.1
39interstitial keratitis10.1
40vasculitis10.1
41enchondroma10.1
42endotheliitis10.1
43paget's disease of bone10.1SQSTM1, TNFRSF11A
44leukopenia10.0IL11, ALPP
45neutropenia10.0IL1RN, IL11
46paget disease, juvenile10.0TNFRSF11B, TNFRSF11A
47giant cell tumor10.0TNFRSF11A, TNFRSF11B
48osteopetrosis10.0TNFRSF11B, TNFRSF11A
49pancreatitis10.0IL11, ALPP
50hypersensitivity reaction type ii disease10.0ALPP, IL1RN

Graphical network of the top 20 diseases related to Periostitis:



Diseases related to periostitis

Symptoms for Periostitis

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Drugs & Therapeutics for Periostitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Periostitis

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Anatomical Context for Periostitis

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34MalaCards
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MalaCards organs/tissues related to Periostitis:

34
Bone, Lung, Endothelial, Heart, Testes, Bone marrow, Brain, Liver, Breast

Animal Models for Periostitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Periostitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.5SQSTM1, IL1RN, TNFRSF11B, TNFRSF11A
2MP:00053908.4TNFRSF11A, TNFRSF11B, IL1RN, SQSTM1
3MP:00053787.9SQSTM1, ALPP, IL1RN, TNFRSF11B, TNFRSF11A
4MP:00107687.6TNFRSF11A, TNFRSF11B, IL1RN, ALPP, SQSTM1

Publications for Periostitis

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53PubMed
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Articles related to Periostitis:

(show top 50)    (show all 403)
idTitleAuthorsYear
1
High-concentration of BMP2 reduces cell proliferation and increases apoptosis via DKK1 and SOST in human primary periosteal cells. (23360788)
2013
2
Oral medicine case book 45. Periosteal osteosarcoma of the mandible. (23957106)
2012
3
Florid-reactive periostitis of the phalanges: a 2-case report. (22327452)
2012
4
Periosteal Flap fixation of the Globe for Surgical Treatment of Severe Restrictive Strabismus: A Report of Eight Cases with Outcomes. (22204549)
2011
5
Platelet-derived growth factor-BB release profile in gingival crevicular fluid after use of marginal periosteal pedicle graft as an autogenous guided tissue membrane to treat localized intrabony defects. (20681813)
2011
6
Periosteal chondroma of the pediatric cervical spine. (19278317)
2009
7
Syphilitic periostitis. (19393487)
2009
8
Survivorship analysis in patients with periosteal chondrosarcoma. (16826117)
2006
9
Concurrent periosteal chondroma and enchondroma of the fibula mimicking chondrosarcoma. (16421751)
2006
10
A rare case of periosteal osteoblastoma located in the frontal cranial bone. (15913430)
2005
11
In vitro osteogenic differentiation and in vivo bone-forming capacity of human isogenic jaw periosteal cells and bone marrow stromal cells. (16327496)
2005
12
FGF-2 enhances TGF-beta1-induced periosteal chondrogenesis. (15304287)
2004
13
Repair of full-thickness cartilage defects in rabbit knees with free periosteal graft preincubated with transforming growth factor. (12722910)
2003
14
Periosteal hyperostosis (exostosis) in DBA/1 male mice. (12051556)
2002
15
Prevention of postoperative meatal stenosis with anteriorly and inferiorly based periosteal flaps in congenital aural atresia surgery. (11773841)
2002
16
Periosteal chondroma presenting as a subcutaneous mass in the thumb. (11733159)
2001
17
Isolation of a cDNA sequence of rabbit GDF5 (mature form) and pattern of its mRNA expression during periosteal chondrogenesis. (11252805)
2000
18
Florid reactive periostitis ossificans of the proximal aspect of the tibia: a lesion that must be distinguished from osteosarcoma. A case report. (10428133)
1999
19
Gross periostitis ossificans in mandibular osteomyelitis. Review of the English literature and radiographic variation. (9768431)
1998
20
Traumatic ossifying periostitis of the ulna masquerading as a malignancy in a football player. A case report and literature review. (8947411)
1996
21
Musculoskeletal case of the day. Periosteal (juxtacortical) chondroma. (7785598)
1995
22
Mechanical loading stimulates rapid changes in periosteal gene expression. (7895187)
1994
23
Scintigraphic diagnosis of costal periostitis in actinomycosis. (1638850)
1992
24
Iliac periosteal graft with vascular pedicle in the treatment of avascular necrosis of the femoral head. Experimental study and clinical application. (1291204)
1992
25
Effect of lipopolysaccharide from Porphyromonas gingivalis on prostaglandin E2 and interleukin-1-beta release from rat periosteal and human gingival fibroblasts in vitro. (1668251)
1991
26
Cranial fasciitis of childhood with reactive periostitis. (2305359)
1990
27
Massive florid reactive periostitis. (2191267)
1990
28
Bizarre parosteal osteochondromatous proliferation vs. benign florid reactive periostitis. (3492900)
1987
29
Periosteal chondroma: a review of the literature and case report. (3512684)
1986
30
Florid reactive periostitis of the proximal phalanx. Case report. (4019546)
1985
31
Periostitis and osteitis associated with hyaline bodies. (2413879)
1985
32
Pain and periostitis. (4045899)
1985
33
Periosteal chondroma: another cause of carpal tunnel syndrome. (6721390)
1984
34
Periosteal chondroma. A review of twenty cases. (6822582)
1983
35
Ossifying granulomatous periostitis in the course of erythema nodosum. (753821)
1978
36
Periosteal chondroma. (4506239)
1972
37
Cellulitis with underlying inflammatory periostitis of the mandible. (5769294)
1969
38
Periostitis: an early diagnostic sign of juvenile rheumatoid arthritis. (6022368)
1967
39
Electron microscopic study of periosteal hyperostosis in rats with lathyrism induced by aminoacetonitrile. (5234345)
1966
40
PERIOSTITIS OSSIFICANS; ETIOLOGY OF FORMATION AND REPORT OF A CASE. (14176596)
1964
41
Chronic polyostotic periostitis of unknown etiology. (14036714)
1961
42
Pulmonary hypertrophic osteoarthropathy (periostitis); its absence in pulmonary tuberculosis. (13552924)
1958
43
Periostitis of the os calcis; an osteoperiosteal manifestation of rheumatoid arthritis. (18856913)
1948
44
Traumatic Periostitis of Orbit: Further Note on Case shown November 13, 1931, as one of Dacryoadenitis. (19988799)
1932
45
Periostitis. ? Cause. (19988280)
1931
46
Osteo-periostitis of Upper End of Femur. (19978339)
1914
47
Acute Periostitis of Rib with Separation of Sequestra (Non-tuberculous, Non-traumatic). (19975692)
1912
48
Acute Infectious Osteomyelitis and Periostitis. (17857400)
1889
49
Periostitis in Typhoid Fever. (20751254)
1885
50
Vitamin-C Deficiency and Periostitis of Both UlnA (20916142)
.? Scurvy.

Variations for Periostitis

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Expression for genes affiliated with Periostitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Periostitis

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Pathways for genes affiliated with Periostitis

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51PathCards, 61Thomson Reuters, 54QIAGEN, 58SinoBiological, 55R&D Systems, 39NCBI BioSystems Database, 31KEGG, 56Reactome
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Pathways related to Periostitis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway61
9.6SQSTM1, TNFRSF11A
2
Show member pathways
9.5TNFRSF11B, TNFRSF11A
3
Show member pathways
9.5TNFRSF11B, TNFRSF11A
49.5TNFRSF11A, TNFRSF11B
59.5TNFRSF11A, TNFRSF11B
6
Show member pathways
Prolactin Signaling Pathway39
Development Prolactin receptor signaling61
Leptin signaling pathway39
9.4IL1RN, TNFRSF11A
7
Show member pathways
9.4IL1RN, SQSTM1
8
Show member pathways
IL-1 Signaling Pathway39
IL1-mediated signaling events39
9.4SQSTM1, IL1RN
99.2IL11, TNFRSF11A
10
Show member pathways
RANKL/RANK Signaling Pathway39
Apoptosis and survival APRIL and BAFF signaling61
9.1SQSTM1, TNFRSF11B, TNFRSF11A
119.1SQSTM1, TNFRSF11B, TNFRSF11A
12
Show member pathways
8.7IL11, TNFRSF11B, TNFRSF11A

Compounds for genes affiliated with Periostitis

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46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 62Tocris Bioscience, 25HMDB, 3BitterDB
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Compounds related to Periostitis according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1denosumab46 1210.9TNFRSF11B, TNFRSF11A
2polyethylene469.9TNFRSF11A, TNFRSF11B
3etidronate469.8TNFRSF11B, ALPP
4vitamin k2469.8TNFRSF11B, ALPP
5pamidronate46 52 1211.7ALPP, TNFRSF11B
6risedronate46 52 30 62 1213.7TNFRSF11B, ALPP
7anakinra46 1210.7IL1RN, TNFRSF11B
8pmma469.5ALPP, TNFRSF11B
9pyridinoline469.5ALPP, TNFRSF11B
10zoledronic acid469.4ALPP, TNFRSF11B
11filgrastim46 1210.3IL11, IL1RN
12atorvastatin46 52 30 25 1213.2TNFRSF11B, IL1RN, ALPP
13prednisolone46 30 1211.2TNFRSF11B, IL1RN, ALPP
14hydrocortisone46 3 62 1212.2ALPP, IL1RN, TNFRSF11B
15gp 130469.1IL11, TNFRSF11B, TNFRSF11A
16titanium469.0ALPP, IL11, TNFRSF11B
17deoxypyridinoline469.0TNFRSF11B, IL11, ALPP
18alendronate46 52 1211.0ALPP, IL11, TNFRSF11B
19polymyxin b469.0IL1RN, TNFRSF11B
20ascorbic acid46 2510.0ALPP, IL1RN, TNFRSF11B
21sb 20358046 6210.0ALPP, IL1RN, TNFRSF11B
22etanercept46 52 1210.9TNFRSF11B, IL11, IL1RN
23infliximab46 52 1210.9IL1RN, IL11, TNFRSF11B
24pge1468.9ALPP, IL1RN, IL11
25polyethylene glycol468.9IL11, IL1RN, ALPP
26tgf beta1468.9IL1RN, IL11, TNFRSF11B
27rantes468.8IL1RN, IL11, TNFRSF11B
28norepinephrine46 25 1210.8SQSTM1, ALPP, IL1RN
29indomethacin46 30 62 1211.7TNFRSF11B, IL11, IL1RN
30hydroxyapatite468.7ALPP, IL11, TNFRSF11B, TNFRSF11A
311,25 dihydroxy vitamin d3468.6TNFRSF11A, TNFRSF11B, IL11, ALPP
32calcitriol46 62 25 1211.6ALPP, IL11, TNFRSF11B, TNFRSF11A
33prostaglandin468.5TNFRSF11A, TNFRSF11B, IL11, IL1RN
34fibrinogen468.5TNFRSF11B, IL11, IL1RN
35phosphatidylinositol468.4TNFRSF11A, TNFRSF11B, IL11, IL1RN
36nitric oxide46 25 1210.4IL1RN, IL11, TNFRSF11B, TNFRSF11A
37oxygen46 259.4TNFRSF11A, IL11, IL1RN, SQSTM1
38vitamin d468.4TNFRSF11B, IL11, IL1RN, ALPP
39cyclosporin a46 30 6210.4TNFRSF11B, IL11, IL1RN, ALPP
40heparin46 30 25 1211.4TNFRSF11B, IL11, IL1RN, ALPP
41cycloheximide468.4TNFRSF11B, IL11, IL1RN, ALPP
42retinoic acid46 259.2TNFRSF11B, IL11, IL1RN, ALPP
43cysteine468.2TNFRSF11B, IL11, IL1RN, ALPP
44pge2468.0TNFRSF11A, TNFRSF11B, IL11, IL1RN, ALPP
45dexamethasone46 52 30 1211.0TNFRSF11A, TNFRSF11B, IL11, IL1RN, ALPP
46vegf468.0TNFRSF11A, TNFRSF11B, IL11, IL1RN, ALPP
47tyrosine468.0TNFRSF11A, TNFRSF11B, IL11, IL1RN, SQSTM1
48estrogen468.0TNFRSF11A, TNFRSF11B, IL11, IL1RN, ALPP
49calcium46 52 25 1210.9TNFRSF11A, TNFRSF11B, IL11, IL1RN, ALPP
50serine467.6TNFRSF11A, TNFRSF11B, IL11, IL1RN, ALPP, SQSTM1

GO Terms for genes affiliated with Periostitis

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17Gene Ontology
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Biological processes related to Periostitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:0324969.4IL1RN, TNFRSF11A
2positive regulation of JUN kinase activityGO:0435079.1IL1RN, TNFRSF11A

Products for genes affiliated with Periostitis

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Sources for Periostitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet