MCID: PRS037
MIFTS: 45

Periostitis malady

Summaries for Periostitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Periostitis, also known as periostalgia, is a medical condition caused by inflammation of the... more...

MalaCards: Periostitis is related to arthritis and secondary syphilis. An important gene associated with Periostitis is IDH1 (isocitrate dehydrogenase 1 (NADP+), soluble), and among its related pathways are 2-Oxocarboxylic acid metabolism and Osteoclast Signaling. The compounds estrogen and procollagen have been mentioned in the context of this disorder. Related mouse phenotypes are limbs/digits/tail and craniofacial.

Aliases & Classifications for Periostitis

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 35MeSH, 25ICD10
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Related Diseases for Periostitis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Periostitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 176)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.4BMP2, ALPP, MMP13, GDF5, COL2A1, TNFRSF11A
2secondary syphilis30.1TNFRSF11A, IBSP, BMP2, BMP4, IL11, PTH
3osteonecrosis30.0BMP2, ALPP
4osteitis fibrosa30.0PTH, ALPP
5renal osteodystrophy30.0ALPP, PTH
6hypercalcemia29.7TNFRSF11A, PTH, ALPP, TGIF1
7cleft palate29.7BMP4, BMP2, COL2A1
8tuberculosis29.7IL11, PDGFB
9osteoarthritis29.7IBSP, TNFRSF11A, MATN3, BMP2, BMP4, GDF5
10periosteal chondrosarcoma10.6
11osteoblastoma10.4
12syphilis10.3
13periosteal osteogenic sarcoma10.3
14alveolar periostitis10.2
15osteochondroma10.2
16juxtacortical chondroma10.2
17polyarteritis nodosa10.2
18orbital periostitis10.2
19typhoid fever10.2
20vasculitis10.2
21gingival recession10.1
22juxtacortical chondrosarcoma10.1
23osteochondritis dissecans10.1
24bone osteosarcoma10.1
25enchondroma10.1
26moyamoya disease10.0
27crohn's disease10.0
28periarthritis10.0
29chondroblastoma10.0
30erdheim-chester disease10.0
31late congenital syphilis10.0
32cellulitis10.0
33myositis ossificans10.0
34systemic scleroderma10.0
35raine syndrome10.0
36hyperphosphatemic familial tumoral calcinosis10.0
37generalized pustular psoriasis10.0
38chronic pain10.0
39myelofibrosis10.0IL11
40prostatitis10.0SRD5A1
41metaphyseal dysplasia10.0COL2A1
42obesity10.0SRD5A1
43periodontal disease10.0ALPP
44inflammatory bowel disease10.0ALPP
45hypertension10.0PTH
46chondrosarcoma10.0BMP2, MMP13
47thyroid cancer10.0PTH, IBSP
48synostosis10.0BMP4
49gingivitis10.0MMP13, ALPP
50pancreatitis10.0ALPP, IL11

Graphical network of the top 20 diseases related to Periostitis:



Diseases related to periostitis

Clinical Features for Periostitis

Drugs & Therapeutics for Periostitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Periostitis

Drug clinical trials:

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Search NIH Clinical Center for Periostitis

Search CenterWatch for Periostitis

Genetic Tests for Periostitis

Anatomical Context for Periostitis

Animal Models for Periostitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Periostitis

Sources:
51PubMed
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Articles related to Periostitis:

(show top 50)    (show all 237)
idTitleAuthorsYear
1
Florid reactive periostitis of the hand. (23994115)
2013
2
Multifocal periostitis as a complication of chronic use of voriconazole in a lung transplant recipient. (23663268)
2013
3
Bilateral femoral periostitis revealing polyarteritis nodosa. (24272984)
2013
4
Medication-induced periostitis in lung transplant patients: periostitis deformans revisited. (20652242)
2011
5
Syphilitic periostitis. (19393487)
2009
6
Physiological periostitis in a 2.5-month-old baby. (19817280)
2009
7
Periostitis and hypertrophic pulmonary osteoarthropathy: report of 2 cases and review of the literature. (18760449)
2009
8
Periostitis ossificans (GarrA"'s osteomyelitis) radiographic study of two cases. (16364095)
2006
9
Childhood onset of psoriatic onycho-pachydermo-periostitis (POPP). (16268902)
2005
10
Clinical images: Drumstick-like fingers indicating psoriatic onycho-pachydermo periostitis. (16142729)
2005
11
Florid reactive periostitis of the hands. (15248034)
2004
12
Periostitis and hypertrophic osteoarthropathy: etiologies and bone scan patterns in 115 cases. (15522572)
2004
13
Bilateral treponema periostitis. (15569562)
2003
14
Sclerosing osteomyelitis of GarrAc periostitis ossificans. (12457091)
2002
15
Localized polyarteritis nodosa with periostitis. (11764232)
2001
16
Oral and maxillofacial pathology case of the month. Proliferative periostitis. (11862861)
2001
17
Periostitis in a patient with ulcerative colitis. (17039184)
2001
18
Psoriatic onycho-pachydermo periostitis: treatment with methotrexate. (11069487)
2000
19
Ulnar periostitis due to stress in hockey players. (11032236)
2000
20
Gross periostitis ossificans in mandibular osteomyelitis. Review of the English literature and radiographic variation. (9768431)
1998
21
Florid reactive periostitis of the thumb. (8732419)
1996
22
Periostitis of the upper extremity: a report of 2 cases and literature review. (8595760)
1996
23
Radiographic investigation of mandibular periostitis ossificans in 55 cases. (8974145)
1996
24
Florid reactive periostitis. (7592279)
1995
25
Psoriatic onycho-periostitis. Report of three cases. (7863282)
1995
26
Case report 834: Chronic sclerosing osteomyelitis of the mandible with long bone periostitis. (8016677)
1994
27
Periodontal infection leading to periostitis ossificans ("GarrA"'s osteomyelitis") of the mandible. Report of a case. (8426291)
1993
28
Scintigraphic diagnosis of costal periostitis in actinomycosis. (1638850)
1992
29
Periostitis ossificans versus GarrA"'s osteomyelitis. Part I. What did GarrA" really say? (3041342)
1988
30
Periostitis in hypertrophic osteoarthropathy: relationship to disease duration. (3493663)
1987
31
Florid reactive periostitis. (3794254)
1986
32
Periostitis and osteitis associated with hyaline bodies. (2413879)
1985
33
Periostitis in secondary syphilis: a place for bone scintigraphy. (4045902)
1985
34
Multifocal recurrent periostitis responsive to colchicine. (4001881)
1985
35
The nature of the hyaline rings in chronic periostitis and other conditions: an ultrastructural study. (6165952)
1981
36
Epidemiology of odontogenic periostitis. (6769830)
1980
37
Uncommon complications of early syphilis. Hepatitis, periostitis, iritis with papillitis, and meningitis. (5015962)
1972
38
PERIOSTITIS DUE TO GIANT-CELL ARTERITIS. (14294435)
1965
39
Traumatic periostitis and subdural hematoma. (13383832)
1956
40
A case of creeping periostitis. (12990924)
1952
41
Postoperative stricture and periostitis pubis following retropubic prostatectomy. (15391239)
1949
42
Periostitis of the os calcis; an osteoperiosteal manifestation of rheumatoid arthritis. (18856913)
1948
43
Traumatic Periostitis. (19993620)
1947
44
Vitamin-C Deficiency and Periostitis of Both Ulnae.? Scurvy. (19991745)
1939
45
Periostitis of the Metatarsus. (21031708)
1927
46
Osteo-periostitis of Upper End of Femur. (19978339)
1914
47
Acute Periostitis of Rib with Separation of Sequestra (Non-tuberculous, Non-traumatic). (19975692)
1912
48
Periostitis in Typhoid Fever. (20751254)
1885
49
Periostitis following Typhoid Fever. (20751253)
1885
50
Periostitis following Typhoid Fever. (20751119)
1885

Genetic Variations for Periostitis

Expression for genes affiliated with Periostitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Periostitis

Search GEO for disease gene expression data for Periostitis.

Pathways for genes affiliated with Periostitis

Sources:
30KEGG, 38NCBI BioSystems Database, 54Reactome, 56SinoBiological, 12EMD Millipore, 52QIAGEN
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Pathways related to Periostitis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3IDH2, IDH1
210.3PDGFB, TNFRSF11A
310.2PTH, PDGFB, IBSP
410.2GDF5, BMP4, BMP2
5
Hide members
10.2GDF5, BMP4, BMP2
610.2BMP2, BMP4, GDF5
710.2COL2A1, MMP13, PTH
810.1MIA, BMP4, COL2A1
9
Development Hedgehog and PTH signaling pathways in bone and cartilage development
Hide members
10.1COL2A1, IBSP, MMP13, PTH
10
Hide members
10.1GDF5, BMP4, BMP2, PDGFB
11
Hide members
10.0MMP13, GDF5, BMP4, BMP2, PDGFB
12
Hide members
10.0GDF5, BMP4, BMP2, PDGFB, COL2A1
13
Hide members
10.0PDGFB, BMP2, BMP4, GDF5, IL11
14
Hide members
9.9GDF5, BMP4, BMP2, TNFRSF11A, PDGFB, IL11
15
Hide members
9.9PDGFB, TNFRSF11A, BMP2, BMP4, GDF5, IL11
16
Hide members
9.9PDGFB, TNFRSF11A, BMP2, BMP4, GDF5, IL11
17
Hide members
9.8MMP13, GDF5, MATN3, BMP4, BMP2, PDGFB
18
Hide members
9.8COL2A1, PDGFB, TNFRSF11A, BMP2, BMP4, GDF5

Compounds for genes affiliated with Periostitis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB, 29IUPHAR, 60Tocris Bioscience
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Compounds related to Periostitis according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1estrogen4510.8SRD5A1
2procollagen4510.7ALPP, COL2A1
3deoxypyridinoline4510.5IBSP, IL11, PTH
4estradiol45 11 2412.5SRD5A1, IBSP, HSD17B13
5alizarin4510.5IBSP, ALPP, BMP2
6forskolin45 50 1112.5PTH, IL11, IBSP
7chitosan4510.5BMP2, ALPP, IBSP
8pyridinoline4510.4IBSP, COL2A1, ALPP
9zoledronic acid4510.4BMP2, IBSP, ALPP
10retinoid4510.4HSD17B13, MMP13, TGIF1, ALPP
11glycosaminoglycan4510.4COL2A1, MMP13, IBSP, BMP2, GDF5
12cycloheximide4510.4PDGFB, PTH, COL2A1, ALPP, IBSP
13prostaglandin4510.4TGIF1, TNFRSF11A, PTH, IL11
14hydroxyproline45 11 2412.4COL2A1, IBSP, MMP13, PTH, ALPP
15titanium4510.3IL11, BMP4, ALPP, IBSP, BMP2
16alendronate45 50 1112.3BMP2, MMP13, ALPP, IL11, PTH
17azathioprine45 50 2 1113.3PDGFB, BMP2, BMP4, IL11
18heparin45 29 11 2413.3IBSP, IL11, BMP2, MMP13, TGIF1
19alginate4510.3MMP13, COL2A1, BMP2
20ibmx45 29 6012.3IBSP, PTH, ALPP, BMP2
21tgf beta14510.2PDGFB, BMP2, BMP4, IL11, TGIF1, MMP13
22pd 98,0594510.2BMP4, BMP2, MMP13, ALPP, PDGFB, IBSP
23fibroin4510.2IBSP, BMP2
24hydroxyapatite4510.2ALPP, IL11, BMP2, TNFRSF11A, MMP13, IBSP
25dihydrotestosterone45 29 11 2413.2HSD17B13, BMP2, SRD5A1, TGIF1
261,25 dihydroxy vitamin d34510.1ALPP, IBSP, TNFRSF11A, BMP2, PTH, TGIF1
27serine4510.1COL2A1, PDGFB, TNFRSF11A, BMP2, MMP13, ALPP
28phenytoin45 50 29 1113.1SRD5A1, ALPP, PDGFB
29creatinine4510.1PTH, TGIF1, BMP2, IBSP, HSD17B13, ALPP
30cyclic amp45 2411.1NT5E, IBSP, MMP13, IL11, TGIF1, PTH
31dexamethasone45 50 29 1113.1PDGFB, ALPP, PTH, MMP13, BMP2, TGIF1
32calcitriol45 60 11 2413.1ALPP, TGIF1, SRD5A1, IL11, BMP2, TNFRSF11A
33ribonucleic acid4510.1PTH, TGIF1, IL11, BMP4, MMP13, BMP2
34ascorbic acid45 2411.0HSD17B13, ALPP, BMP4, IBSP, MMP13, COL2A1
35oligonucleotide4510.0PDGFB, IBSP, BMP2, COL2A1, IL11, BMP4
36progesterone45 60 29 11 2414.0PDGFB, SRD5A1, IL11, HSD17B13, TGIF1, BMP4
37steroid4510.0BMP2, IBSP, BMP4, IL11, SRD5A1, TGIF1
38vitamin d4510.0SRD5A1, COL2A1, IBSP, BMP2, IL11, TGIF1
39genistein45 29 60 2 11 2415.0MMP13, BMP2, TGIF1, SRD5A1, ALPP
40oxygen45 2411.0BMP2, PDGFB, TGIF1, TNFRSF11A, MMP13, COL2A1
41thymidine45 2411.0ALPP, PTH, MMP13, IL11, BMP4, BMP2
42testosterone45 60 11 2412.9BMP2, SRD5A1, PTH, ALPP, TGIF1, HSD17B13
43nitric oxide45 11 2411.9PTH, MMP13, IL11, BMP4, TNFRSF11A, COL2A1
44cysteine459.9COL2A1, BMP4, GDF5, IL11, BMP2, MMP13
45cyclosporin a45 29 6011.9BMP2, PDGFB, ALPP, IL11, BMP4
46retinoic acid45 2410.9ALPP, TGIF1, IL11, SRD5A1, COL2A1, BMP2
47dehydroepiandrosterone sulfate459.8HSD17B13, SRD5A1, PTH
48tyrosine459.7TNFRSF11A, TGIF1, PTH, IL11, GDF5, PDGFB
49vegf459.5TNFRSF11A, ALPP, PTH, SRD5A1, MMP13, IL11
50calcium45 50 11 2412.4MMP13, KL, COL2A1, IDH1, MATN3, TNFRSF11A

GO Terms for genes affiliated with Periostitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Periostitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.4COL2A1, PDGFB, BMP2, BMP4, MIA, GDF5
2extracellular regionGO:0055769.0PTH, KL, COL2A1, HSD17B13, IBSP, PDGFB

Biological processes related to Periostitis according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1glyoxylate cycleGO:00609710.7IDH1, IDH2
2isocitrate metabolic processGO:00610210.6IDH1, IDH2
3mesenchymal cell proliferation involved in ureteric bud developmentGO:07213810.6BMP2, BMP4
4BMP signaling pathway involved in heart inductionGO:00313010.6BMP2, BMP4
5telencephalon regionalizationGO:02197810.6BMP4, BMP2
6regulation of odontogenesis of dentin-containing toothGO:04248710.6BMP4, BMP2
7cellular response to growth factor stimulusGO:07136310.5IBSP, PDGFB, BMP4
8chondrocyte differentiationGO:00206210.5BMP4, BMP2, COL2A1
9proteoglycan metabolic processGO:00602910.5BMP2, COL2A1
10positive regulation of endothelial cell proliferationGO:00193810.5BMP4, BMP2, PDGFB
11positive regulation of cartilage developmentGO:06103610.5BMP2, BMP4
12cartilage developmentGO:05121610.5COL2A1, GDF5, MMP13
13positive regulation of ossificationGO:04577810.4BMP2, BMP4
14skeletal system developmentGO:00150110.4COL2A1, BMP2, MATN3, PTH
15positive regulation of bone mineralizationGO:03050110.4KL, BMP2, BMP4, PTH
16positive regulation of MAPK cascadeGO:04341010.4PDGFB, BMP2, IL11
17embryonic skeletal joint morphogenesisGO:06027210.4BMP4, COL2A1
18positive regulation of neuron differentiationGO:04566610.4BMP2, BMP4, TGIF1
19cellular response to BMP stimulusGO:07177310.3COL2A1, BMP2
20cell-cell signalingGO:00726710.3PTH, IL11, GDF5, BMP2, TNFRSF11A
212-oxoglutarate metabolic processGO:00610310.3IDH1, IDH2
22positive regulation of ERK1 and ERK2 cascadeGO:07037410.3PDGFB, BMP2, BMP4
23SMAD protein signal transductionGO:06039510.3BMP4, BMP2
24monocyte chemotaxisGO:00254810.2PDGFB, TNFRSF11A
25extracellular matrix organizationGO:03019810.1MMP13, COL2A1, IBSP, PDGFB, BMP2, BMP4
26telencephalon developmentGO:02153710.0BMP4, BMP2

Molecular functions related to Periostitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1isocitrate dehydrogenase (NADP+) activityGO:00445010.3IDH2, IDH1
2platelet-derived growth factor bindingGO:04840710.3PDGFB, COL2A1
3BMP receptor bindingGO:07070010.0BMP4, BMP2
4cytokine activityGO:00512510.0BMP2, BMP4, GDF5, IL11
5growth factor activityGO:0080839.9IL11, PDGFB, BMP2, BMP4, MIA, GDF5

Products for genes affiliated with Periostitis

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  • Proteins
  • Lysates
  • Antibodies

Sources for Periostitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet