Periostitis malady

Wikipedia: Periostitis, also known as periostalgia, is a medical condition caused by inflammation of the...⁴⁴ more...

MalaCards: Periostitis is related to thrombocytopenia and meningioma. An important gene associated with Periostitis is MIA (melanoma inhibitory activity), and among its related pathways are Actin-Based Motility by Rho Family GTPases and Akt Signaling. The compounds threonine and glycosaminoglycan have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, b cells and endothelial, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Aliases & Descriptions:

periostitis 6 43

Diseases related to periostitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 569)

id	Related Disease	Score	Top Affiliating Genes
1	thrombocytopenia	25.0	CD36, IL11, IL1A, IL1B, IL1RN, ALPP
2	meningioma	22.3	VEGFA, BMP4, KDR, MUC1, FOS, FLT1
3	chondrosarcoma	20.9	VEGFA, BMP2, BMP7, BGLAP, MUC1, CD36
4	gingivitis	20.7	VEGFA, BMP2, BGLAP, KDR, MUC1, CD36
5	osteosarcoma	20.0	VEGFA, BMP2, BMP4, BMP7, BGLAP, MUC1
6	sarcoma	17.2	VEGFA, BMP2, BMP4, BMP7, BGLAP, KDR
7	interval angle-closure glaucoma	13.8	IDH1, IDH2
8	spindle cell hemangioma	13.8	IDH1, IDH2
9	enchondroma	13.7	MMP13, IDH1, IDH2
10	semd	13.7	MMP13, MATN3, COL2A1
11	clear cell adenoma	13.7	ALPP, PTH
12	tumoral calcinosis, hyperphosphatemic	13.6	KL, GALNT3
13	hyperphosphatemic familial tumoral calcinosis	13.6	KL, GALNT3
14	metaphyseal dysplasia	13.6	MATN3, PTH, COL2A1
15	familial hypophosphatemia	13.6	KL, ALPP, PTH
16	male pseudohermaphroditism due to defective lh	13.6	ALPP, HSD17B13, SRD5A1
17	idiopathic juvenile osteoporosis	13.5	BGLAP, CD36, PTH
18	x-linked magnesium deficiency with epstein-barr virus infection and neoplasia	13.5	BGLAP, TNFRSF11A, PTH
19	cleidocranial dysplasia	13.5	BMP2, BGLAP, MMP13
20	polyostotic osteolytic dysplasia, hereditary expansile	13.5	TNFRSF11A, TNFRSF11B, SQSTM1
21	epiphyseal dysplasia	13.5	CD36, MATN3, COL2A1
22	synostosis	13.5	BMP2, BMP4, FGFR2, GDF5
23	multiple epiphyseal dysplasia	13.5	CD36, MATN3, COL2A1
24	achondrogenesis type ii	13.5	CD36, COL2A1
25	osteitis fibrosa	13.5	BGLAP, IL11, ALPP, PTH
26	pseudoachondroplasia	13.4	CD36, MATN3, COL2A1
27	ollier disease	13.4	CD36, IDH1, IDH2, CTSB
28	spondylolisthesis	13.4	BMP2, BMP7, MMP3
29	dwarfism	13.4	FGFR2, MATN3, PTH, COL2A1, GDF5
30	brachydactyly	13.4	BMP2, PTH, COL2A1, GDF5
31	osteopenia/osteoporosis	13.4	BGLAP, CD36, TNFRSF11B
32	hypocalcemia	13.3	BGLAP, CD36, ALPP, PTH
33	osteoarthritis susceptibility 6	13.3	MMP13, MMP3, TNFRSF11B
34	chronic ulcer of skin	13.3	CD36, MMP13, FGF2, PDGFB
35	thyrotoxicosis	13.3	BGLAP, CD36, IL11, ALPP
36	mammary paget's disease	13.3	BGLAP, TNFRSF11B, SQSTM1
37	calcinosis	13.3	KL, ALPP, PTH, SPP1, GALNT3
38	progressive osseous heteroplasia	13.3	BMP2, BMP4, BMP7, BGLAP, ALPP
39	amenorrhea	13.2	BGLAP, ALPP, HSD17B13, TNFRSF11B
40	villonodular synovitis	13.2	BGLAP, IBSP, TNFRSF11B, SPP1
41	avascular necrosis of femoral head	13.2	VEGFA, BMP2, COL2A1
42	rickets	13.2	KL, BGLAP, CD36, ALPP, PTH
43	hypophosphatemia	13.2	KL, BGLAP, FGF2, ALPP, PTH
44	hypoparathyroidism	13.2	BGLAP, ALPP, DYT10, PTH
45	pigmented villonodular synovitis	13.2	BGLAP, IBSP, TNFRSF11B, SPP1
46	fibrodysplasia ossificans progressiva	13.2	BMP2, BMP4, FOS, FGF2
47	chondrodysplasia	13.2	CD36, FGFR2, MATN3, PTH, COL2A1, GDF5
48	osteochondritis dissecans	13.2	BMP7, CD36, MMP13, MMP3, MATN3
49	megakaryocytic leukemia	13.2	CD36, FGFR2, IL11, TNFRSF11B
50	pseudohypoparathyroidism	13.2	BGLAP, FGFR2, PTH

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to periostitis:

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MGI Mouse Phenotypes related to periostitis:

²⁵ (show all 25)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.0	KL, COL2A1, PDGFB
2	endocrine/exocrine gland phenotype	MP:0005379	10.0	GALNT3, POSTN, PTH, FGFR2, MIA, KL
3	craniofacial phenotype	MP:0005382	9.6	POSTN, TGIF1, COL2A1, PTH, GRB2, FGFR2
4	hematopoietic system phenotype	MP:0005397	9.5	SQSTM1, PDGFB, NT5E, PTH, TNFRSF11A, FGFR2
5	embryogenesis phenotype	MP:0005380	9.4	COL2A1, ALPP, GRB2, FGFR2, FOS
6	liver/biliary system phenotype	MP:0005370	9.4	SQSTM1, COL2A1, CD36, BMP4, VEGFA
7	renal/urinary system phenotype	MP:0005367	9.3	PDGFB, COL2A1, NT5E, CTSB, FGFR2, BMP7
8	integument phenotype	MP:0010771	9.1	SQSTM1, CTSB, TNFRSF11A, FGFR2, MIA, FOS
9	hearing/vestibular/ear phenotype	MP:0005377	8.4	COL2A1, TNFRSF11B, GRB2, FGFR2, FGF2, FOS
10	immune system phenotype	MP:0005387	8.3	PTH, CTSB, COL2A1, SQSTM1, POSTN, MATN3
11	limbs/digits/tail phenotype	MP:0005371	7.9	GDF5, KL, VEGFA, BMP2, GALNT3, POSTN
12	behavior/neurological phenotype	MP:0005386	7.8	SPP1, CTSB, NT5E, COL2A1, SQSTM1, TNFRSF11A
13	nervous system phenotype	MP:0003631	7.5	SPP1, COL2A1, TGFB1, TGIF1, SQSTM1, FGF2
14	growth/size phenotype	MP:0005378	7.2	KL, PTH, TNFRSF11B, TNFRSF11A, ALPP, IBSP
15	normal phenotype	MP:0002873	7.0	FGFR2, GRB2, ALPP, CTSB, COL2A1, TGIF1
16	tumorigenesis	MP:0002006	7.0	POSTN, TGFB1, CTSB, SPP1, IL1B, IL1A
17	digestive/alimentary phenotype	MP:0005381	7.0	TGFB1, COL2A1, CTSB, GRB2, FGFR2, CD36
18	reproductive system phenotype	MP:0005389	6.5	SRD5A1, SPP1, PDGFB, TGFB1, POSTN, GALNT3
19	muscle phenotype	MP:0005369	6.5	FGFR2, SPP1, PDGFB, TGFB1, POSTN, FGF2
20	vision/eye phenotype	MP:0005391	6.5	TGFB1, PDGFB, COL2A1, FGFR2, FGF2, FLT1
21	mortality/aging	MP:0010768	6.4	IL1B, TNFRSF11A, TNFRSF11B, PTH, CTSB, COL2A1
22	skeleton phenotype	MP:0005390	6.2	GDF5, GALNT3, POSTN, SQSTM1, COL2A1, SPP1
23	cellular phenotype	MP:0005384	5.1	IL1RN, TNFRSF11A, TNFRSF11B, SPP1, CTSB, TGFB1
24	cardiovascular system phenotype	MP:0005385	4.4	IL1B, IL1RN, TNFRSF11B, PTH, SPP1, NT5E
25	homeostasis/metabolism phenotype	MP:0005376	3.5	CTSB, SPP1, TNFRSF11A, IL1RN, IL1B, NT5E

Articles related to periostitis:

(show all 33)

id	Title	Authors	Year	Affiliating Genes
1	Platelet-derived growth factor-BB release profile in gingival crevicular fluid after use of marginal periosteal pedicle graft as an autogenous guided tissue membrane to treat localized intrabony defects. (20681813)	Gamal A.Y.... Fakhry E.M.	2011	PDGFB
2	IDH1 and IDH2 mutations are frequent events in centra l chondrosarcoma and central and periosteal chondromas but not in other mesench ymal tumours. (21598255)	Amary M.F.... Flanagan A.M.	2011	IDH1, IDH2
3	Vascular endothelial growth factor stimulates osteobl astic differentiation of cultured human periosteal-derived cells expressing vas cular endothelial growth factor receptors. (20842453)	Hah Y.S.... Byun J.H.	2011	FLT1, KDR, VEGFA
4	Osteoinduction in umbilical cord- and palate perioste um-derived mesenchymal stem cells. (20395805)	Caballero M.... van Aalst J.A.	2010	BMP2, NT5E, BGLAP
5	Bone morphogenetic protein 2 stimulates endochondral ossification by regulating periosteal cell fate during bone repair. (20348041)	Yu Y.Y.... Colnot C.	2010	BMP2
6	Coculture between periosteal explants and articular c hondrocytes induces expression of TGF-beta1 and collagen I. (19952089)	GrAossel S.... Anders S.	2010	COL2A1, MIA
7	Origin of cardiac fibroblasts and the role of periost in. (19893021)	Snider P.... Conway S.J.	2009	POSTN
8	Bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) transfection to human periosteal cells enhances osteoblast differentiation and bone formation. (18776714)	Samee M.... Kuroda S.	2008	BMP2, CD36, BGLAP
9	Vascular endothelial growth factor expression in cult ured periosteal-derived cells. (18296084)	Park B.W.... Byun J.H.	2008	BGLAP
10	Periosteal osteoblastoma of the calvaria mimicking a meningioma. (18359169)	Tawil A.... Chamoun R.	2008	MUC1
11	FGF2 effects in periosteal fibroblasts bearing the FGFR2 receptor Pro253 Arg mutation. (17537644)	Lilli C.... Bodo M.	2007	FGFR2, FGF2
12	Apert p.Ser252Trp mutation in FGFR2 alters osteogenic potential and gene expression of cranial periosteal cells. (17622301)	Fanganiello R.D.... Passos-Bueno M.R.	2007	FGFR2
13	Tumor induced by Moloney sarcoma virus causes periosteal osteogenesis engaging osteopontin, fibronectin, stromelysin-1 and tenascin. (17319793)	Wlodarski P.... Wlodarski K.H.	2007	MMP3
14	Sporadic hyperphosphatasia syndrome featuring periostitis and accelerated skeletal turnover without receptor activator of nuclear factor-kappaB, osteoprotegerin, or sequestosome-1 gene defects. (17284635)	Simsek S.... Netelenbos J.C.	2007	TNFRSF11B, ALPP, SQSTM1
15	In vitro osteogenic differentiation and in vivo bone-forming capacity of human isogenic jaw periosteal cells and bone marrow stromal cells. (16327496)	JaquiAcry C.... Martin I.	2005	SPP1, IBSP
16	Tissue engineered bone regeneration of periosteal ce lls using recombinant human bone morphogenetic protein 2 induce (15759922)	Zhang C.... Cui F.	2005	CD36
17	FGF-2 enhances TGF-beta1-induced periosteal chondrogenesis. (15304287)	Stevens M.M.... Prasad Shastri V.	2004	TGFB1, FGF2
18	Repair of full-thickness cartilage defects in rabbit knees with free periosteal graft preincubated with transforming growth factor. (12722910)	Hsieh P.C.... Balian G.	2003	TGIF1
19	Periostitis secondary to interleukin-11 (Oprelvekin, Neumega). Treatment for thrombocytopenia in pediatric patients. (12728286)	Milman E.... Ruzal-Shapiro C.	2003	IL11
20	Basic fibroblast growth factor: effects on matrix remodeling, receptor expression, and transduction pathway in human periosteal fibroblasts with FGFR2 gene mutation. (12162872)	Bodo M.... Carinci P.	2002	FGFR2, FGF2, GRB2
21	Parathyroid hormone and periosteal bone expansion. (12369776)	Parfitt A.M.	2002	PTH
22	Modulatory effects of indomethacin on androgen metabolism in human gingival and oral periosteal fibroblasts. (11711113)	Tilakaratne A.... Soory M.	2001	SRD5A1, HSD17B13
23	Isolation of a cDNA sequence of rabbit GDF5 (mature form) and pattern of its mRNA expression during periosteal chondrogenesis. (11252805)	Sanyal A.... O'Driscoll S.W.	2000	GDF5
24	The effect of minocycline on the metabolism of androgens by human oral periosteal fibroblasts and its inhibition by finasteride. (10708666)	Soory M.... Tilakaratne A.	2000	SRD5A1
25	Gene-enhanced tissue engineering: applications for bone healing using cultured periosteal cells transduced retrovirally with the BMP-7 gene. (10340856)	Breitbart A.S.... Grant R.T.	1999	BMP7
26	Participation of intracellular cysteine proteinases, in particular cathepsin B, in degradation of collagen in periosteal tissue explants. (9569125)	Creemers L.B.... Everts V.	1998	CTSB
27	Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development. (9056642)	Johansson N.... Kahari V.M.	1997	MMP13
28	Vitamin K2 promotes 1alpha,25(OH)2 vitamin D3-induced mineralization in human periosteal osteoblasts. (8939773)	Koshihara Y.... Shiraki M.	1996	ALPP, BGLAP
29	Periosteal sunburst spiculation in osteosarcoma. A possible role for bone morphogenetic protein. (7955686)	Yoshikawa H.... Takaoka K.	1994	BMP4
30	Time-dependent effects of parathyroid hormone and pro staglandin E2 on DNA synthesis by periosteal cells from embryonic chick calvari a. (7987735)	Scutt A.... Mayer H.	1994	DYT10
31	Interleukin-1 alpha and epidermal growth factor synergistically enhance the release of collagenase by periosteal connective tissue in vitro. (8246834)	van der Zee E.... Beertsen W.	1993	IL1A
32	Effect of lipopolysaccharide from Porphyromonas gingi valis on prostaglandin E2 and interleukin-1-beta release from rat periosteal an d human gingival fibroblasts in vitro. (1668251)	Sismey-Durrant H.J.... Hopps R.M.	1991	IL1B
33	c-fos oncogene expression in dexamethasone stimulated osteogenic cells in chick embryo periosteal cultures. (1773132)	Birek C.... Tenenbaum H.C.	1991	FOS

Genes related to periostitis according to GeneCards:

(show all 43)

id	Symbol	Description	Score	GeneCards Section Context
1	MIA	melanoma inhibitory activity	11.0	Publications
2	HSD17B13	hydroxysteroid (17-beta) dehydrogenase 13	11.0	Publications
3	MATN3	matrilin 3	11.0
4	NT5E	5'-nucleotidase, ecto (CD73)	11.0	Publications
5	IDH2	isocitrate dehydrogenase 2 (NADP+), mitochondrial	11.0	Publications
6	POSTN	periostin, osteoblast specific factor	11.0	Publications
7	GALNT3	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)	11.0
8	GDF5	growth differentiation factor 5	11.0	Publications
9	IDH1	isocitrate dehydrogenase 1 (NADP+), soluble	11.0	Publications
10	IBSP	integrin-binding sialoprotein	11.0	Publications
11	KL	klotho	11.0
12	TNFRSF11A	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	11.0	Publications
13	PTH	parathyroid hormone	11.0	Publications
14	IL11	interleukin 11	11.0	Publications
15	MMP13	matrix metallopeptidase 13 (collagenase 3)	11.0	Publications
16	TGIF1	TGFB-induced factor homeobox 1	11.0	Publications
17	SRD5A1	steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)	11.0	Publications
18	SQSTM1	sequestosome 1	11.0	Publications
19	PDGFB	platelet-derived growth factor beta polypeptide	11.0	Publications
20	BMP4	bone morphogenetic protein 4	11.0	Publications
21	COL2A1	collagen, type II, alpha 1	11.0	Publications
22	BMP2	bone morphogenetic protein 2	11.0	Publications
23	BMP7	bone morphogenetic protein 7	11.0	Publications
24	FGFR2	fibroblast growth factor receptor 2	11.0	Publications
25	ALPP	alkaline phosphatase, placental	11.0	Publications
26	BGLAP	bone gamma-carboxyglutamate (gla) protein	11.0	Publications
27	CTSB	cathepsin B	11.0	Publications
28	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
29	SPP1	secreted phosphoprotein 1	11.0	Publications
30	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	11.0	Publications
31	GRB2	growth factor receptor-bound protein 2	11.0	Publications
32	FGF2	fibroblast growth factor 2 (basic)	11.0	Publications
33	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11.0	Publications
34	FOS	FBJ murine osteosarcoma viral oncogene homolog	11.0	Publications
35	FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	11.0	Publications
36	IL1A	interleukin 1, alpha	11.0	Publications
37	MUC1	mucin 1, cell surface associated	11.0	Publications
38	IL1RN	interleukin 1 receptor antagonist	11.0
39	KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	11.0	Publications
40	DYT10	dystonia 10	11.0	Publications
41	VEGFA	vascular endothelial growth factor A	11.0	Publications
42	TGFB1	transforming growth factor, beta 1	11.0	Publications
43	IL1B	interleukin 1, beta	11.0	Publications

Pathways related to periostitis according to GeneDecks:

(show top 50)    (show all 109)

id	Pathway	Score	Top Affiliating Genes
1	Actin-Based Motility by Rho Family GTPases36	10.0	GDF5, BMP7, BMP4
2	Akt Signaling36	9.8	PDGFB, TNFRSF11A, BMP7, BMP4, IL11, BMP2
3	eIF2 Pathway36	9.5	FGF2, GDF5, GRB2, FGFR2, BMP7, BMP4
4	Development Hedgehog and PTH signaling pathways in bone and cartilage development10	9.4	IBSP, BGLAP, PTH, SPP1, FOS, COL2A1
5	PPAR Pathway36	9.2	BMP4, FLT1, FGF2, GRB2, PDGFB, FGFR2
6	CREB Pathway36	9.1	FGFR2, KDR, GDF5, GRB2, BMP7, BMP4
7	Breast Cancer Regulation by Stathmin136	9.0	BMP4, BMP2, BMP7, FGF2, FGFR2, GRB2
8	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	8.8	SPP1, IL1A, TNFRSF11A, FOS, BGLAP, TNFRSF11B
9	Telomerase Components in Cell Signaling36	8.8	BMP7, KDR, BMP4, FGF2, FLT1, PDGFB
10	ILK Signaling36	8.7	FGFR2, PDGFB, COL2A1, FGF2, FOS, KDR
11	Transcription Role of VDR in regulation of genes involved in osteoporosis10	8.7	IL1A, IL1B, BGLAP, TNFRSF11A, TNFRSF11B, PTH
12	Paxillin Interactions36	8.6	BMP4, KDR, FLT1, FGFR2, GRB2, BMP2
13	PTEN Pathway36	8.6	FGFR2, GRB2, PDGFB, GDF5, FGF2, FLT1
14	Endothelin-1 Signaling Pathway36	8.4	BMP4, IL11, IL1B, IL1A, GRB2, FGFR2
15	14-3-3 Induced Intracellular Signaling36	8.2	BMP7, BMP2, BMP4, FLT1, FGF2, FGFR2
16	Apoptotic Pathways in Synovial Fibroblasts36	8.0	GDF5, BMP2, BMP4, TGFB1, PDGFB, FGFR2
17	p53 Mediated Apoptosis36	7.9	FGF2, TGFB1, FGFR2, KDR, PDGFB, BMP7
18	Mitochondrial Apoptosis36	7.9	TGFB1, FGF2, FLT1, BMP7, BMP4, BMP2
19	Cellular Apoptosis Pathway36	7.8	BMP2, BMP4, PDGFB, FGFR2, FGF2, FLT1
20	Nuclear Receptor Activation by Vitamin-A36	7.8	BMP2, BMP7, KDR, FGF2, FGFR2, PDGFB
21	Nanog in Mammalian ESC Pluripotency36	7.7	FGFR2, GRB2, PDGFB, FGF2, GDF5, TGFB1
22	ERK5 Signaling36	7.7	TGFB1, BMP2, PDGFB, FGFR2, FGF2, FLT1
23	Rac1 Pathway36	7.7	PDGFB, FLT1, BMP7, BMP4, KDR, TGFB1
24	p70S6K Signaling36	7.7	GDF5, PDGFB, FGFR2, FGF2, FLT1, BMP7
25	IP3 Pathway36	7.7	BMP4, BMP7, KDR, BMP2, FLT1, FGF2
26	DHA Signaling36	7.5	PDGFB, GDF5, FGFR2, IL1B, FGF2, KDR
27	Renin-Angiotensin Pathway36	7.5	TGFB1, BMP2, BMP7, PDGFB, GRB2, FGFR2
28	Ras Pathway36	7.5	FOS, TGFB1, KDR, BMP4, BMP2, GDF5
29	NFAT in Immune Response36	7.5	FGF2, BMP4, BMP7, KDR, FOS, BMP2
30	Estrogen Pathway36	7.4	KDR, FGFR2, GDF5, TGFB1, PDGFB, GRB2
31	GPCR Pathway36	7.4	FGFR2, PDGFB, FGF2, FLT1, GDF5, TGFB1
32	Pancreatic Adenocarcinoma36	7.4	BMP4, KDR, MMP3, FLT1, FGF2, FGFR2
33	Tec Kinases Signaling36	7.4	TNFRSF11A, IL1B, TGFB1, IL1A, FGF2, PDGFB
34	Rheumatoid arthritis20	7.4	IL1B, VEGFA, MMP3, FOS, FLT1, IL11
35	Activation of PKC through GPCR36	7.3	FGFR2, FGF2, FLT1, KDR, BMP7, BMP4
36	Molecular Mechanisms of Cancer36	7.3	FGF2, GRB2, FGFR2, IL11, GDF5, TGFB1
37	Phospholipase-C Pathway36	7.3	BMP2, FGFR2, GRB2, SPP1, COL2A1, PDGFB
38	JNK Pathway36	7.3	FLT1, PDGFB, FGFR2, FGF2, BMP2, BMP4
39	NF-KappaB (p50-p65) Pathway36	7.2	FLT1, KDR, BMP7, BMP4, BMP2, FGF2
40	NF-KappaB Family Pathway36	7.2	FGF2, FLT1, FGFR2, KDR, BMP7, BMP4
41	PAK Pathway36	7.1	BMP4, KDR, TGFB1, PDGFB, IL1B, FLT1
42	MAPK Family Pathway36	6.8	TGFB1, PDGFB, IL1B, IL1A, IL11, BMP2
43	Cytokine-cytokine receptor interaction20	6.7	TNFRSF11B, FLT1, BMP2, BMP7, KDR, IL11
44	p38 Signaling36	6.7	FLT1, BMP2, KDR, BMP7, BMP4, TGFB1
45	Antioxidant Action of Vitamin-C36	6.7	IL11, TGFB1, PDGFB, TNFRSF11A, IL1B, IL1A
46	JAK-STAT Pathway36	6.5	BMP2, IL1B, BMP4, IL11, FOS, GDF5
47	TGF-Beta Pathway36	6.5	BMP7, KDR, FOS, FLT1, FGF2, FGFR2
48	Rho Family GTPases36	6.4	PDGFB, BMP7, BMP4, BMP2, COL2A1, KDR
49	MAPK Signaling36	6.3	GDF5, TGFB1, FGFR2, BMP2, BMP4, KDR
50	ERK Signaling36	6.1	BMP4, GDF5, TGFB1, PDGFB, COL2A1, SPP1

Compounds related to periostitis according to GeneDecks:

(show top 50)    (show all 225)

id	Compound	Score	Top Affiliating Genes
1	threonine32	10.3	FGFR2, BMP2
2	glycosaminoglycan32	9.5	BMP2, CD36, MMP13, FGF2, FGFR2, IBSP
3	hyaluronic acid32 18	10.5	FGF2, IL11, MMP3, MMP13, MUC1, CD36
4	alizarin32	9.3	ALPP, BMP2, BGLAP, CD36, IBSP, SPP1
5	titanium32	9.3	BMP2, BMP4, BMP7, BGLAP, CD36, IL11
6	h2o232	9.2	ALPP, IL1RN, GRB2, FGFR2, BGLAP, TGIF1
7	deoxypyridinoline32	9.2	TNFRSF11B, ALPP, IBSP, IL11, CD36, BGLAP
8	progesterone32 42 9 18 9	13.2	BMP2, BMP4, BMP7, PDGFB, TGIF1, SRD5A1
9	alendronate32 9 9	11.2	MMP13, MMP3, IL11, ALPP, TNFRSF11B, PTH
10	pyridinoline32	9.1	BGLAP, COL2A1, CD36, MMP3, IBSP, ALPP
11	hydroxyapatite32	8.8	BMP2, BMP7, BGLAP, CD36, MMP13, IL11
12	hydroxyproline32 18	9.5	BGLAP, CD36, MMP13, IBSP, ALPP, TNFRSF11B
13	ascorbic acid32 18	9.3	BMP2, BMP4, BMP7, BGLAP, CD36, MMP13
14	cysteine32	8.3	BMP4, FGFR2, BGLAP, KDR, GDF5, COL2A1
15	ns 39832 42	9.3	BGLAP, TGFB1, TNFRSF11B, IL1B, IL1A, FGF2
16	calcitriol32 42 9 18 9	12.1	TGIF1, SPP1, SRD5A1, BMP7, BMP2, BGLAP
17	herbimycin a32 42	9.1	FOS, SPP1, IL1B, IL1A, IL11, GRB2
18	pge232	7.9	BMP2, BMP4, BMP7, MMP13, MMP3, FGF2
19	tgf beta132	7.9	TNFRSF11B, SPP1, TGIF1, IL1RN, IL11, BMP7
20	infliximab32 9 9	9.8	VEGFA, MMP3, TNFRSF11B, IL11, IL1B, IL1RN
21	1,25 dihydroxy vitamin d332	7.8	CTSB, TGFB1, TGIF1, SPP1, PTH, BMP2
22	heparin32 9 18 9	10.7	BMP4, BGLAP, CD36, MMP13, MMP3, FLT1
23	procollagen32	7.3	BMP2, BGLAP, CD36, MMP13, MMP3, IL1A
24	alginate32	7.3	BMP2, BMP7, BGLAP, CD36, MMP13, MMP3
25	hydrocortisone32 9 9	9.2	IL1RN, IL1B, IL1A, FGF2, FLT1, CD36
26	ly29400232	7.2	SPP1, TGFB1, CTSB, IL1B, VEGFA, FOS
27	tamoxifen32 34 9 9	10.1	FOS, FGFR2, ALPP, GRB2, MUC1, KDR
28	creatinine32	7.0	CTSB, TGFB1, SPP1, PTH, BMP2, BMP7
29	forskolin32 42 9 9	9.9	BMP4, MUC1, MMP3, FOS, TGIF1, PTH
30	pd 98,05932	6.7	BMP4, ALPP, IBSP, IL1B, FGFR2, FOS
31	calcium32 9 18 9	9.7	KL, BMP2, BMP4, BMP7, BGLAP, MUC1
32	indomethacin32 9 9	8.7	MMP3, MMP13, IL1A, IL11, BMP2, KDR
33	estrogen32	6.7	BMP2, BMP4, BMP7, BGLAP, KDR, CD36
34	cyclosporin a32 42	7.6	BMP2, BMP4, BGLAP, KDR, MMP3, FGF2
35	vitamin d32	6.6	BMP2, BMP7, BGLAP, CD36, MMP3, FGFR2
36	matrigel32	6.5	FLT1, FGF2, IBSP, SPP1, CTSB, TGFB1
37	phosphatidylinositol32	6.2	IL1RN, KDR, FOS, SPP1, DYT10, TNFRSF11B
38	nitric oxide32 9 18 9	9.2	BMP2, TGIF1, PDGFB, COL2A1, CTSB, PTH
39	paraffin32	6.1	CD36, MMP13, MMP3, FLT1, FGF2, FGFR2
40	actinomycin d32	5.9	BMP4, VEGFA, TGFB1, CTSB, SPP1, DYT10
41	ribonucleic acid32	5.8	SPP1, PDGFB, TGFB1, TGIF1, BMP2, BMP4
42	thymidine32 18	6.3	KDR, MUC1, MMP13, FOS, FLT1, FGF2
43	genistein32 9 18 9	8.3	GRB2, IL1A, IL1B, ALPP, TNFRSF11B, DYT10
44	sb 20358032 42	5.9	VEGFA, BMP2, BMP4, BGLAP, CD36, MMP13
45	cycloheximide32	4.3	VEGFA, PDGFB, COL2A1, CTSB, SPP1, BMP2
46	tyrosine32	4.3	MMP3, GDF5, SQSTM1, FOS, FLT1, FGF2
47	retinoic acid32 42 18	5.5	IL1RN, ALPP, TNFRSF11B, DYT10, SRD5A1, SPP1
48	serine32	3.3	BMP4, BMP7, BGLAP, KDR, MUC1, CD36
49	dexamethasone32 42 34 9 9	7.2	VEGFA, TNFRSF11B, PTH, SRD5A1, SPP1, CTSB
50	vegf32	1.9	MUC1, TNFRSF11B, DYT10, PTH, SRD5A1, SPP1

Cellular components related to periostitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	membrane-bounded vesicle	GO:031988	9.5	SPP1, IBSP, BGLAP, BMP4, BMP2
2	cell surface	GO:009986	7.8	PDGFB, ALPP, IL1A, FGFR2, CD36, BMP2
3	proteinaceous extracellular matrix	GO:005578	7.7	POSTN, TGFB1, TNFRSF11B, MATN3, MMP3, MMP13
4	extracellular space	GO:005615	4.6	KL, IL1B, IL1RN, IBSP, TNFRSF11B, PTH
5	extracellular region	GO:005576	4.5	HSD17B13, IBSP, IL1B, IL1A, TNFRSF11B, PTH

Biological processes related to periostitis according to GeneDecks:

(show top 50)    (show all 77)

id	Name	GO ID	Score	Top Affiliating Genes
1	osteoblast differentiation	GO:001649	10.4	BMP4, BGLAP
2	negative regulation of mitosis	GO:045839	10.3	FGFR2, BMP7, BMP4
3	mesenchymal cell differentiation	GO:048762	10.3	BMP2, BMP7, FGFR2
4	bone development	GO:060348	10.2	SRD5A1, FGFR2, BGLAP
5	monocyte chemotaxis	GO:002548	10.1	PDGFB, TNFRSF11A, FLT1
6	SMAD protein signal transduction	GO:060395	10.1	BMP2, BMP4, BMP7, FOS
7	response to mechanical stimulus	GO:009612	10.1	BMP2, BMP4, BGLAP, CTSB
8	negative regulation of cell death	GO:060548	10.1	BMP4, BMP7, FGF2, CTSB
9	negative regulation of glomerular mesangial cell proliferation	GO:072125	10.0	BMP7, BMP4
10	cartilage development	GO:051216	10.0	BMP2, BMP7, COL2A1, GDF5
11	positive regulation of osteoblast differentiation	GO:045669	10.0	FGF2, BMP7, BMP4, BMP2
12	glyoxylate cycle	GO:006097	10.0	IDH2, IDH1
13	cellular response to dexamethasone stimulus	GO:071549	9.7	BMP4, SRD5A1, TGFB1
14	skeletal system development	GO:001501	9.6	POSTN, COL2A1, PTH, TNFRSF11B, MATN3, BGLAP
15	extracellular matrix organization	GO:030198	9.6	COL2A1, TNFRSF11B, IBSP, MMP3, MMP13
16	peptidyl-tyrosine phosphorylation	GO:018108	9.6	PDGFB, FGFR2, FLT1, KDR
17	pathway-restricted SMAD protein phosphorylation	GO:060389	9.6	TGFB1, BMP7, BMP2
18	response to organic cyclic compound	GO:014070	9.6	BMP4, IL1A, IL1RN, CTSB, PDGFB
19	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:010862	9.5	BMP2, BMP4, BMP7, TGFB1
20	ureteric bud development	GO:001657	9.5	TGFB1, FGFR2, BMP7, BMP4
21	negative regulation of cell cycle	GO:045786	9.5	TGFB1, BMP7, BMP4, BMP2
22	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.5	VEGFA, CD36, IL11, PDGFB
23	positive regulation of MAPK cascade	GO:043410	9.4	PDGFB, IL11, FGFR2, FLT1, CD36, KDR
24	positive chemotaxis	GO:050918	9.4	VEGFA, BMP4, FGF2
25	cellular response to growth factor stimulus	GO:071363	9.4	TGIF1, TGFB1, SRD5A1, IBSP, BMP4, BMP2
26	cellular response to vascular endothelial growth factor stimulus	GO:035924	9.3	FLT1, KDR, VEGFA
27	positive regulation of bone mineralization	GO:030501	9.3	TGFB1, PTH, BMP7, BMP4, BMP2, KL
28	cell migration involved in sprouting angiogenesis	GO:002042	9.3	FGF2, KDR, VEGFA
29	positive regulation of phosphatidylinositol 3-kinase activity	GO:043552	9.3	TGFB1, PDGFB, FGF2, FLT1
30	cell-cell signaling	GO:007267	9.3	GDF5, PTH, TNFRSF11A, IL1B, IL11, GRB2
31	transforming growth factor beta receptor signaling pathway	GO:007179	9.3	GDF5, TGIF1, TGFB1, PDGFB, FOS
32	cellular response to organic cyclic compound	GO:071407	9.2	TGFB1, SRD5A1, IL1B, BMP2
33	positive regulation of vascular endothelial growth factor receptor signaling pathway	GO:030949	9.2	IL1B, FLT1, VEGFA
34	response to vitamin D	GO:033280	9.1	TGFB1, SPP1, IL1B, BGLAP
35	positive regulation of endothelial cell proliferation	GO:001938	9.1	PDGFB, FGF2, KDR, BMP4, BMP2, VEGFA
36	positive regulation of blood vessel endothelial cell migration	GO:043536	9.0	TGFB1, PDGFB, FGF2, VEGFA
37	positive regulation of MAP kinase activity	GO:043406	8.9	TGFB1, PDGFB, FLT1, VEGFA
38	positive regulation vascular endothelial growth factor production	GO:010575	8.8	IL1A, IL1B, TGFB1
39	response to drug	GO:042493	8.7	TGIF1, TGFB1, PDGFB, SRD5A1, TNFRSF11B, IL1RN
40	positive regulation of ERK1 and ERK2 cascade	GO:070374	8.7	BMP2, PDGFB, IL1B, IL1A, FGFR2, FGF2
41	platelet activation	GO:030168	8.6	TGFB1, PDGFB, IL11, GRB2, CD36, VEGFA
42	positive regulation of protein phosphorylation	GO:001934	8.6	VEGFA, BMP2, BMP4, IL1B, TGFB1
43	positive regulation of angiogenesis	GO:045766	8.4	IL1B, IL1A, FGF2, FLT1, KDR, VEGFA
44	positive regulation of cell migration	GO:030335	8.3	TGFB1, PDGFB, FLT1, KDR, BMP2, VEGFA
45	negative regulation of cell proliferation	GO:008285	8.3	TGIF1, TGFB1, IL1B, IL1A, FGFR2, FGF2
46	positive regulation of transcription, DNA-dependent	GO:045893	8.2	TGFB1, PDGFB, IL1B, FGF2, FOS, BMP7
47	positive regulation of cell division	GO:051781	8.0	TGFB1, PDGFB, IL1B, IL1A, FGFR2, FGF2
48	response to hypoxia	GO:001666	7.9	TGFB1, PDGFB, IL1B, IL1A, FLT1, BMP2
49	positive regulation of cell proliferation	GO:008284	7.8	TGFB1, PDGFB, TNFRSF11A, IL11, FGFR2, FGF2
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.4	SQSTM1, TGFB1, PTH, IL1B, IL1A, IL11

Molecular functions related to periostitis according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	isocitrate dehydrogenase (NADP+) activity	GO:004450	10.3	IDH1, IDH2
2	fibroblast growth factor binding	GO:017134	9.6	FGFR2, FGF2, KL
3	chemoattractant activity	GO:042056	9.3	VEGFA, BMP4, FGF2
4	interleukin-1 receptor binding	GO:005149	9.3	IL1RN, IL1B, IL1A
5	heparin binding	GO:008201	9.1	POSTN, FGFR2, FGF2, BMP4, VEGFA
6	cytokine activity	GO:005125	7.6	VEGFA, GDF5, SPP1, TNFRSF11B, IL1B, IL1A
7	growth factor activity	GO:008083	7.4	IL1B, PDGFB, TGFB1, GDF5, IL11, FGF2