MCID: PRP009
MIFTS: 42

Peripartum Cardiomyopathy malady

Categories: Rare diseases, Reproductive diseases, Cardiovascular diseases

Aliases & Classifications for Peripartum Cardiomyopathy

Aliases & Descriptions for Peripartum Cardiomyopathy:

Name: Peripartum Cardiomyopathy 50 56 69
Postpartum Cardiomyopathy 50 56 69
Meadows' Syndrome 50

Characteristics:

Orphanet epidemiological data:

56
peripartum cardiomyopathy
Age of onset: Adult;

Classifications:



External Ids:

Orphanet 56 ORPHA563
UMLS via Orphanet 70 C0877208 C0269972
ICD10 via Orphanet 34 O90.3

Summaries for Peripartum Cardiomyopathy

MalaCards based summary : Peripartum Cardiomyopathy, also known as postpartum cardiomyopathy, is related to transmitted_by and cardiomyopathy. An important gene associated with Peripartum Cardiomyopathy is PRL (Prolactin), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Neuroscience. The drugs Selenium and Antioxidants have been mentioned in the context of this disorder. Affiliated tissues include heart, myeloid and cardiac myocytes, and related phenotypes are cardiovascular system and muscle

Wikipedia : 71 Peripartum cardiomyopathy (PPCM) is a form of dilated cardiomyopathy that is defined as a deterioration... more...

Related Diseases for Peripartum Cardiomyopathy

Diseases related to Peripartum Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
id Related Disease Score Top Affiliating Genes
1 transmitted_by 32.0 DRD2 PRL
2 cardiomyopathy 11.0
3 rhinoscleroma 10.2 DRD2 PRL
4 lung occult small cell carcinoma 10.2 DRD2 PRL
5 ornithosis 10.2 DRD2 PRL
6 pulmonary neuroendocrine tumor 10.2 DRD2 PRL
7 luxation of globe 10.2 ADRB1 PRL
8 aplasia cutis congenita recessive 10.2 ADRB1 GNB3
9 infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovasuclar malformations 10.1 DRD2 PRL
10 dilated cardiomyopathy 10.1
11 nephrogenic adenoma of the urethra 10.1 DRD2 PRL
12 cold-induced sweating syndrome 2 10.1 DRD2 PRL
13 pre-eclampsia 10.0
14 eclampsia 10.0
15 left ventricular noncompaction 10.0
16 celiac disease 2 10.0 MYH7 TTN
17 lyme disease 10.0 MYH7 TTN
18 familial sick sinus syndrome 10.0 GNB3 SCN5A
19 cardiac arrest 10.0
20 bile acid synthesis defect, congenital, 4 10.0 DRD2 PRL
21 muscular dystrophy, rigid spine, 1 10.0 MYH7 TTN
22 trs2-related diamond-blackfan anemia with mandibulofacial dysostosis 9.9 MYH7 SCN5A
23 ndp-related retinopathy of prematurity 9.9 MYH7 SCN5A
24 selenon-related myopathy 9.9 MYH7 SCN5A
25 sema4a-related retinitis pigmentosa 9.9 MYH7 SCN5A
26 sudden infant death syndrome 9.9 MYH7 SCN5A
27 ostertagiasis 9.9 MYH7 TTN
28 myocarditis 9.9
29 pulmonary edema 9.9
30 hyperprolactinemia 9.9
31 mosaic trisomy 1 9.9 MYH7 SCN5A
32 retinitis pigmentosa 18 9.9 MYH7 SCN5A
33 tardbp-related frontotemporal dementia 9.9 MYH7 SCN5A
34 cardiogenic shock 9.8
35 myocardial infarction 9.8
36 systemic lupus erythematosus 9.8
37 lupus erythematosus 9.8
38 pulmonary embolism 9.8
39 ventricular septal defect 9.8
40 primary cutaneous gamma/delta-positive t-cell lymphoma 9.7 MYH7 SCN5A TTN
41 pollen allergy 9.7 MYH7 SCN5A TTN
42 schizophrenia 9.7
43 cerebritis 9.7
44 hemiplegia 9.7
45 pneumonia 9.7
46 chlamydia 9.7
47 obesity 9.7
48 influenza 9.7
49 heart disease 9.7
50 myeloid leukemia 9.7

Graphical network of the top 20 diseases related to Peripartum Cardiomyopathy:



Diseases related to Peripartum Cardiomyopathy

Symptoms & Phenotypes for Peripartum Cardiomyopathy

MGI Mouse Phenotypes related to Peripartum Cardiomyopathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 CHRM2 DRD2 MYH7 SCN5A TTN ADRB1
2 muscle MP:0005369 9.1 ADRB1 CHRM2 DRD2 MYH7 SCN5A TTN

Drugs & Therapeutics for Peripartum Cardiomyopathy

Drugs for Peripartum Cardiomyopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Selenium Approved, Vet_approved Phase 4 7782-49-2
2 Antioxidants Phase 4
3 Micronutrients Phase 4
4 Protective Agents Phase 4
5 Selenious Acid Phase 4
6 Sodium Selenite Phase 4
7 Trace Elements Phase 4
8
Bromocriptine Approved, Investigational Phase 3,Phase 2 25614-03-3 31101
9
Dopamine Approved Phase 3,Phase 2 51-61-6, 62-31-7 681
10
Dalteparin Approved Phase 3 9041-08-1
11
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
12 Antiparkinson Agents Phase 3,Phase 2
13 Dopamine Agents Phase 3,Phase 2
14 Dopamine agonists Phase 3,Phase 2
15 Hormone Antagonists Phase 3,Phase 2
16 Hormones Phase 3,Phase 2
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
18 Neurotransmitter Agents Phase 3,Phase 2
19 calcium heparin Phase 3
20 Heparin, Low-Molecular-Weight Phase 3
21 Angiotensin-Converting Enzyme Inhibitors Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Peripartum Cardiomyopathy in Nigeria Registry Not yet recruiting NCT03081949 Phase 4
2 Bromocriptine in the Treatment of Peripartum Cardiomyopathy Not yet recruiting NCT02590601 Phase 3
3 Effect of Bromocriptine on Left Ventricular Function in Women With Peripartum Cardiomyopathy Completed NCT00998556 Phase 2
4 Registry and Survey of Women With Pregnancy Related Cardiomyopathy Unknown status NCT00273637
5 Investigation in Pregnancy Associate Cardiomyopathy Completed NCT01085955
6 The Study of Cardiovascular Outcomes in Women With Preeclampsia Using Echocardiography: The SCOPE Study Recruiting NCT02357667

Search NIH Clinical Center for Peripartum Cardiomyopathy

Genetic Tests for Peripartum Cardiomyopathy

Anatomical Context for Peripartum Cardiomyopathy

MalaCards organs/tissues related to Peripartum Cardiomyopathy:

39
Heart, Myeloid, Cardiac Myocytes, Testes, Lung, Liver, Brain

Publications for Peripartum Cardiomyopathy

Articles related to Peripartum Cardiomyopathy:

(show top 50) (show all 550)
id Title Authors Year
1
Re: Myocardial Recovery in Peripartum Cardiomyopathy after Hyperprolactinemia Treatment on Biventricular Assist Device. ( 28114195 )
2017
2
Peripartum Cardiomyopathy in Cardiac MRI: A Case Report. ( 27846644 )
2017
3
Peripartum cardiomyopathy, place of drug therapy, assist devices, and outcome after left ventricular assistance. ( 27776335 )
2017
4
Re: Myocardial Recovery in Peripartum Cardiomyopathy After Hyperprolactinemia Treatment on Biventricular Assist Device. ( 28169846 )
2017
5
Myocardial Recovery in Peripartum Cardiomyopathy After Hyperprolactinemia Treatment on BIVAD. ( 27748657 )
2017
6
Comparison of clinical outcomes in peripartum cardiomyopathy and age-matched dilated cardiomyopathy: A 15-year nationwide population-based study in Asia. ( 28489799 )
2017
7
Low STAT3 expression sensitizes to toxic effects of I^-adrenergic receptor stimulation in peripartum cardiomyopathy. ( 27002120 )
2016
8
Characteristics and In-Hospital Outcomes of Peripartum Cardiomyopathy Diagnosed During Delivery in the United States From the Nationwide Inpatient Sample (NIS) Database. ( 26923643 )
2016
9
Peripartum cardiomyopathy: a systematic literature review. ( 27545093 )
2016
10
Current management of patients with severe acute peripartum cardiomyopathy: practical guidance from the Heart Failure Association of the European Society of Cardiology Study Group on peripartum cardiomyopathy. ( 27338866 )
2016
11
Peripartum Cardiomyopathy Treatment with Dopamine Agonist and Subsequent Pregnancy with a Satisfactory Outcome. ( 27399926 )
2016
12
Peripartum cardiomyopathy with subclinical hypothyroidism - A rare case presentation. ( 27728018 )
2016
13
The Search for a Crystal Ball to Predict Early Recovery From Peripartum Cardiomyopathy? ( 27126284 )
2016
14
An airport meeting that led to bromocriptine use in peripartum cardiomyopathy. ( 28007932 )
2016
15
Right Ventricular Function in Peripartum Cardiomyopathy at Presentation Is Associated With Subsequent Left Ventricular Recovery and Clinical Outcomes. ( 27166247 )
2016
16
Clinical Profi le and Predictors of Outcomes of Patients with Peripartum Cardiomyopathy: The Philippine Heart Center Experience. ( 27942536 )
2016
17
Clinical Characteristics and Prognosis of Peripartum Cardiomyopathy in 28 Patients. ( 26956861 )
2016
18
Coincidence of peripartum cardiomyopathy and systemic lupus erythematosus. ( 27150565 )
2016
19
Women's Experiences Being Diagnosed With Peripartum Cardiomyopathy: A Qualitative Study. ( 27285199 )
2016
20
Peripartum cardiomyopathy: challenges in diagnosis and management. ( 27276444 )
2016
21
BMI Is a Potential Confounder of Postpartum Relaxin-2 and Short-Term Left Ventricular Function Following Peripartum Cardiomyopathy. ( 27364970 )
2016
22
Peripartum cardiomyopathy in Turkey: Experience of three tertiary centres. ( 26789488 )
2016
23
Cabergoline in the Treatment of Peripartum Cardiomyopathy. ( 27583690 )
2016
24
Peripartum cardiomyopathy in a patient treated for acute myeloid leukemia. ( 27276863 )
2016
25
Angiogenic Imbalance and Residual Myocardial Injury in Recovered Peripartum Cardiomyopathy Patients. ( 28029641 )
2016
26
Physiological Reduction in Left Ventricular Contractile Function in Healthy Postpartum Women: Potential Overlap with Peripartum Cardiomyopathy. ( 26859567 )
2016
27
Immunosuppression therapy in the management of peripartum cardiomyopathy: A case series and literature review. ( 27829880 )
2016
28
Right ventricular systolic dysfunction and remodelling in Nigerians with peripartum cardiomyopathy: a longitudinal study. ( 26821537 )
2016
29
Cardiac arrest during emergency cesarean section for severe pre-eclampsia and peripartum cardiomyopathy. ( 26927264 )
2016
30
A rare case of peripartum cardiomyopathy with atrial septal defect. ( 27728087 )
2016
31
Veno-venous ECMO as a safe bridge to recovery in a patient with severe peripartum cardiomyopathy - learning from errors. ( 27881700 )
2016
32
Peripartum cardiomyopathy: a case of patient with triplet pregnancy. ( 27132428 )
2016
33
Safe and Effective Use of Pharmacologic and Device Therapy for Peripartum Cardiomyopathy. ( 27373996 )
2016
34
Impellaa8c Left Ventricular Assist Device for Acute Peripartum Cardiomyopathy After Cesarean Delivery. ( 27224038 )
2016
35
When it rains, it pours: Peripartum cardiomyopathy with features of left-ventricular noncompaction in a hemodialysis patient. ( 27147549 )
2016
36
Peripartum Cardiomyopathy From a Genetic Perspective. ( 27385280 )
2016
37
Commentary: Peripartum Cardiomyopathy in Intensive Care Unit: An Update. ( 26925403 )
2016
38
Decreased expression of programmed death 1 on peripheral blood lymphocytes disrupts immune homeostasis in peripartum cardiomyopathy. ( 27580218 )
2016
39
Longitudinal systolic strain profiles and outcomes in peripartum cardiomyopathy. ( 27342869 )
2016
40
Peripartum cardiomyopathy: Frequency and predictors and indicators of clinical outcome. ( 27924958 )
2016
41
Relaxin-2 and Soluble Flt1 Levels in Peripartum Cardiomyopathy: Results of the Multicenter IPAC Study. ( 26970832 )
2016
42
Early ivabradine treatment in patients with acute peripartum cardiomyopathy: Subanalysis of the German PPCM registry. ( 27156059 )
2016
43
GNB3 C825T Polymorphism and Myocardial Recovery in Peripartum Cardiomyopathy: Results of the Multicenter Investigations of Pregnancy-Associated Cardiomyopathy Study. ( 26915373 )
2016
44
Expression of programmed cell death-1 and its ligand B7 homolog 1 in peripheral blood lymphocytes from patients with peripartum cardiomyopathy. ( 28026044 )
2016
45
Response: "Commentary: Peripartum Cardiomyopathy in Intensive Care Unit: An Update". ( 27200354 )
2016
46
Mechanical circulatory support for patients with peripartum cardiomyopathy. ( 27003430 )
2016
47
Comment On: Peripartum Cardiomyopathy Treatment with Dopamine Agonist and Subsequent Pregnancy with a Satisfactory Outcome. ( 27875851 )
2016
48
One Year Survival in Nigerians with Peripartum Cardiomyopathy. ( 27512533 )
2016
49
Use of Prolactin Inhibition in the Treatment of Peripartum Cardiomyopathy. ( 27658008 )
2016
50
Quality of Life in Survivors of Peripartum Cardiomyopathy. ( 27239023 )
2016

Variations for Peripartum Cardiomyopathy

Expression for Peripartum Cardiomyopathy

Search GEO for disease gene expression data for Peripartum Cardiomyopathy.

Pathways for Peripartum Cardiomyopathy

GO Terms for Peripartum Cardiomyopathy

Cellular components related to Peripartum Cardiomyopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.5 CHRM2 DRD2 GNB3
2 lateral plasma membrane GO:0016328 9.26 DRD2 SCN5A
3 axon terminus GO:0043679 9.16 CHRM2 DRD2
4 muscle myosin complex GO:0005859 8.96 MYH7 TTN
5 Z disc GO:0030018 8.8 MYH7 SCN5A TTN

Biological processes related to Peripartum Cardiomyopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of epithelial cell proliferation GO:0050679 9.43 PRL SCN5A
2 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007188 9.4 CHRM2 DRD2
3 muscle filament sliding GO:0030049 9.37 MYH7 TTN
4 striated muscle contraction GO:0006941 9.32 MYH7 TTN
5 temperature homeostasis GO:0001659 9.26 ADRB1 DRD2
6 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.16 ADRB1 DRD2
7 cardiac muscle contraction GO:0060048 9.13 MYH7 SCN5A TTN
8 regulation of heart rate GO:0002027 8.8 DRD2 MYH7 SCN5A

Molecular functions related to Peripartum Cardiomyopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 calmodulin binding GO:0005516 9.13 MYH7 SCN5A TTN
2 adrenergic receptor activity GO:0004935 8.62 ADRB1 DRD2

Sources for Peripartum Cardiomyopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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