MCID: PRP009
MIFTS: 53

Peripartum Cardiomyopathy

Categories: Rare diseases, Cardiovascular diseases, Reproductive diseases

Aliases & Classifications for Peripartum Cardiomyopathy

MalaCards integrated aliases for Peripartum Cardiomyopathy:

Name: Peripartum Cardiomyopathy 53 72 49 55 69
Postpartum Cardiomyopathy 49 55 69
Peripartum Cardiomyopathy, Susceptibility to 53
Ppcm, Susceptibility to 53
Meadows' Syndrome 49
Ppcm 53

Characteristics:

Orphanet epidemiological data:

55
peripartum cardiomyopathy
Age of onset: Adult;

Classifications:



External Ids:

OMIM 53 614670
Orphanet 55 ORPHA563
UMLS via Orphanet 70 C0269972 C0877208
ICD10 via Orphanet 33 O90.3
UMLS 69 C0269972

Summaries for Peripartum Cardiomyopathy

OMIM : 53 Peripartum cardiomyopathy (PPCM) is characterized by systolic heart failure presenting in the last month of pregnancy or the first 5 months postpartum. PPCM affects 1 in 300 to 1 in 3,000 pregnancies, with geographic hot spots of high incidence, such as Nigeria and Haiti. Although approximately half of affected women recover cardiac function postpartum, many patients progress to chronic heart failure, cardiac transplantation, or death. Data have suggested that antiangiogenic prolactin (176760) fragments may have an important role in causing the disease in some patients. Risk factors for PPCM also include preeclampsia (see 189800) and multiple gestation, suggesting a potential mechanistic overlap with these processes (summary by Patten et al., 2012). (614670)

MalaCards based summary : Peripartum Cardiomyopathy, also known as postpartum cardiomyopathy, is related to left ventricular noncompaction and cardiac conduction defect. An important gene associated with Peripartum Cardiomyopathy is PRL (Prolactin), and among its related pathways/superpathways are G-Beta Gamma Signaling and Circadian entrainment. The drugs Selenium and Selenious acid have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and cardiac myocytes, and related phenotypes are cardiovascular system and growth/size/body region

NIH Rare Diseases : 49 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 563Disease definitionPeripartum cardiomyopathy (PPCM) is an idiopathic, potentially fatal form of dilated cardiomyopathy that develops during the final month of pregnancy or within five months after delivery.Visit the Orphanet disease page for more resources. Last updated: 1/1/2014

Wikipedia : 72 Peripartum cardiomyopathy (PPCM) is a form of dilated cardiomyopathy that is defined as a deterioration... more...

Related Diseases for Peripartum Cardiomyopathy

Diseases related to Peripartum Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 left ventricular noncompaction 30.4 MYH7 SCN5A TTN
2 cardiac conduction defect 30.2 MYH7 SCN5A
3 syncope 29.7 GNB3 SCN5A
4 dilated cardiomyopathy 29.0 ADRB1 CHRM2 MYH7 PDCD1 SCN5A TTN
5 transmitted_by 11.4
6 galactorrhea 10.3 DRD2 PRL
7 ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy 10.3 MYH7 SCN5A
8 schizophreniform disorder 10.3 DRD2 PRL
9 prolactin producing pituitary tumor 10.3 DRD2 PRL
10 atrial standstill 1 10.2 ADRB1 MYH7 SCN5A
11 social phobia 10.2 DRD2 PRL
12 familial isolated dilated cardiomyopathy 10.2 MYH7 SCN5A TTN
13 intrinsic cardiomyopathy 10.2 MYH7 SCN5A TTN
14 ovarian cyst 10.2 PRL VEGFA
15 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1
16 pre-eclampsia 10.1
17 adenomyosis 10.1 PRL VEGFA
18 meningeal melanomatosis 10.1 NRAS PDCD1
19 aortic coarctation 10.1 ADRB1 GNB3
20 eclampsia 10.1
21 angiokeratoma circumscriptum 10.1 FLT1 VEGFA
22 glomeruloid hemangioma 10.1 FLT1 VEGFA
23 cardiac arrest 10.0
24 capillary hemangioma 10.0 FLT1 VEGFA
25 microcystic meningioma 10.0 FLT1 VEGFA
26 epithelioid hemangioendothelioma 10.0 FLT1 VEGFA
27 cancer-associated retinopathy 10.0 FLT1 VEGFA
28 hyperprolactinemia 10.0
29 hydrops, lactic acidosis, and sideroblastic anemia 10.0
30 pulmonary edema 10.0
31 heart disease 10.0
32 myocarditis 10.0
33 pulmonary embolism 10.0
34 lipodermatosclerosis 10.0 FLT1 VEGFA
35 functioning pituitary adenoma 9.9 DRD2 PRL
36 acute hemorrhagic leukoencephalitis 9.9 FLT1 VEGFA
37 human immunodeficiency virus type 1 9.9
38 genital herpes 9.9
39 systemic lupus erythematosus 9.9
40 cardiomyopathy, dilated, 1b 9.9
41 ventricular fibrillation, paroxysmal familial, 1 9.9
42 muscular dystrophy, congenital, 1b 9.9
43 body mass index quantitative trait locus 1 9.9
44 myocardial infarction 9.9
45 ventricular septal defect 9.9
46 lupus erythematosus 9.9
47 multiple endocrine neoplasia 9.9
48 cardiogenic shock 9.9
49 myopathy, spheroid body 9.9 MYH7 TTN
50 autoimmune disease 9.7

Graphical network of the top 20 diseases related to Peripartum Cardiomyopathy:



Diseases related to Peripartum Cardiomyopathy

Symptoms & Phenotypes for Peripartum Cardiomyopathy

Clinical features from OMIM:

614670

MGI Mouse Phenotypes related to Peripartum Cardiomyopathy:

43 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.24 FLT1 MYH7 NRAS PDCD1 RELA SCN5A
2 growth/size/body region MP:0005378 10.16 RELA SCN5A TTN VEGFA ADRB1 CHRM2
3 homeostasis/metabolism MP:0005376 10.13 ADRB1 CHRM2 DRD2 FLT1 NRAS PDCD1
4 mortality/aging MP:0010768 10.07 ADRB1 DRD2 FLT1 GNB3 NRAS PDCD1
5 endocrine/exocrine gland MP:0005379 10.02 ADRB1 DRD2 NRAS PDCD1 PRL RELA
6 muscle MP:0005369 10.02 ADRB1 CHRM2 DRD2 FLT1 MYH7 PDCD1
7 liver/biliary system MP:0005370 9.95 CHRM2 DRD2 NRAS PDCD1 PRL RELA
8 nervous system MP:0003631 9.91 CHRM2 DRD2 FLT1 GNB3 PDCD1 PRL
9 normal MP:0002873 9.7 TTN VEGFA DRD2 FLT1 NRAS RELA
10 skeleton MP:0005390 9.5 ADRB1 DRD2 NRAS PDCD1 RELA TTN
11 vision/eye MP:0005391 9.23 CHRM2 FLT1 GNB3 NRAS PDCD1 RELA

Drugs & Therapeutics for Peripartum Cardiomyopathy

Drugs for Peripartum Cardiomyopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Selenium Approved, Investigational, Vet_approved Phase 4 7782-49-2
2
Selenious acid Approved, Investigational Phase 4 7783-00-8
3 Micronutrients Phase 4
4 Sodium Selenite Phase 4
5 Trace Elements Phase 4
6 Protective Agents Phase 4
7 Antioxidants Phase 4
8
Dopamine Approved Phase 3,Phase 2 51-61-6, 62-31-7 681
9
Bromocriptine Approved, Investigational Phase 3,Phase 2 25614-03-3 31101
10
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
11
Dalteparin Approved Phase 3 9005-49-6
12 Dopamine agonists Phase 3,Phase 2
13 Neurotransmitter Agents Phase 3,Phase 2
14 Hormone Antagonists Phase 3,Phase 2
15 Hormones Phase 3,Phase 2
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
17 Dopamine Agents Phase 3,Phase 2
18 Antiparkinson Agents Phase 3,Phase 2
19 calcium heparin Phase 3
20 Heparin, Low-Molecular-Weight Phase 3
21 Angiotensin-Converting Enzyme Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Peripartum Cardiomyopathy in Nigeria Registry Recruiting NCT03081949 Phase 4 Oral Sodium Selenite 200 µg/day for 3 months
2 Bromocriptine in the Treatment of Peripartum Cardiomyopathy Recruiting NCT02590601 Phase 3 Bromocriptine
3 Effect of Bromocriptine on Left Ventricular Function in Women With Peripartum Cardiomyopathy Completed NCT00998556 Phase 2 Bromocriptine
4 Registry and Survey of Women With Pregnancy Related Cardiomyopathy Unknown status NCT00273637
5 Investigation in Pregnancy Associate Cardiomyopathy Completed NCT01085955
6 A Registry of Peripartum Cardiomyopathy in Turkey Recruiting NCT03364140
7 Pregnancy and Dilated Cardiomyopathy Recruiting NCT03235063
8 The Study of Cardiovascular Outcomes in Women With Preeclampsia Using Echocardiography: The SCOPE Study Recruiting NCT02357667

Search NIH Clinical Center for Peripartum Cardiomyopathy

Genetic Tests for Peripartum Cardiomyopathy

Anatomical Context for Peripartum Cardiomyopathy

MalaCards organs/tissues related to Peripartum Cardiomyopathy:

38
Heart, T Cells, Cardiac Myocytes, Neutrophil, Monocytes, Testes, Liver

Publications for Peripartum Cardiomyopathy

Articles related to Peripartum Cardiomyopathy:

(show top 50) (show all 587)
# Title Authors Year
1
Subsequent Pregnancy Outcomes in Patients With Peripartum Cardiomyopathy. ( 29324614 )
2018
2
Circulating T-Cell Subsets, Monocytes, and Natural Killer Cells in Peripartum Cardiomyopathy: Results From the Multicenter IPAC Study. ( 29079307 )
2018
3
Peripartum cardiomyopathy: Status 2018. ( 29451958 )
2018
4
The rationale and design of the national peripartum cardiomyopathy registries in Turkey: The ARTEMIS-I and ARTEMIS-II studies. ( 29339690 )
2018
5
Peripartum cardiomyopathy, what if your patient plans to reconceive? ( 28588804 )
2017
6
Bromocriptine for the treatment of peripartum cardiomyopathy: welcome on BOARD. ( 28934838 )
2017
7
Depression and health behaviors in women with Peripartum Cardiomyopathy. ( 28583376 )
2017
8
Re: Myocardial Recovery in Peripartum Cardiomyopathy after Hyperprolactinemia Treatment on Biventricular Assist Device. ( 28114195 )
2017
9
Peripartum cardiomyopathy in Denmark: a retrospective, population-based study of incidence, management and outcome. ( 28597481 )
2017
10
Fatal accelerated rejection with a prominent natural killer cell infiltrate in a heart transplant recipient with peripartum cardiomyopathy. ( 29101003 )
2017
11
Comparison of clinical outcomes in peripartum cardiomyopathy and age-matched dilated cardiomyopathy: A 15-year nationwide population-based study in Asia. ( 28489799 )
2017
12
Poor Outcomes in Poor Patients?: Peripartum Cardiomyopathy-Not Just Black and White. ( 29049487 )
2017
13
A contemporary review of peripartum cardiomyopathy. ( 28765406 )
2017
14
A Case Report of Recurrent Severe Peripartum Cardiomyopathy Complicated by Factor V Leiden and Multiple Endocrine Neoplasia Type 1: A Management Conundrum. ( 29077664 )
2017
15
Bromocriptine for the treatment of peripartum cardiomyopathy: a multicentre randomized study. ( 28934837 )
2017
16
Myofilament remodeling and function is more impaired in peripartum cardiomyopathy compared to dilated cardiomyopathy and ischemic heart disease. ( 28935576 )
2017
17
Understanding the association between hypertensive disorders of pregnancy and peripartum cardiomyopathy. ( 28891239 )
2017
18
Peripartum Cardiomyopathy in Cardiac MRI: A Case Report. ( 27846644 )
2017
19
Impact of Preeclampsia on Clinical and Functional Outcomes in Women With Peripartum Cardiomyopathy. ( 28572214 )
2017
20
December 2017 at a glance: left ventricular ejection fraction, exercise capacity, peripartum cardiomyopathy. ( 29271589 )
2017
21
Peripartum Cardiomyopathy: Do Exosomes Play a Role? ( 28936737 )
2017
22
Peripartum cardiomyopathy for the clinician: the known and the unknown. ( 28653358 )
2017
23
Vasoinhibin Serum Levels Are Required to Demonstrate Their Role in Peripartum Cardiomyopathy Etiopathology. ( 28657930 )
2017
24
The Role of Genetics in Peripartum Cardiomyopathy. ( 28776299 )
2017
25
Re: Myocardial Recovery in Peripartum Cardiomyopathy After Hyperprolactinemia Treatment on Biventricular Assist Device. ( 28169846 )
2017
26
Peripartum cardiomyopathy, place of drug therapy, assist devices, and outcome after left ventricular assistance. ( 27776335 )
2017
27
Myocardial Recovery in Peripartum Cardiomyopathy After Hyperprolactinemia Treatment on BIVAD. ( 27748657 )
2017
28
Clinical outcomes of peripartum cardiomyopathy: a 15-year nationwide population-based study in Asia. ( 29069030 )
2017
29
Peripartum cardiomyopathy is associated with increased uric acid concentrations: A population based study. ( 28779903 )
2017
30
Understanding Peripartum Cardiomyopathy. ( 28813232 )
2017
31
Peripartum cardiomyopathy: diagnosis and management. ( 29122930 )
2017
32
Contraception and reproductive counseling in women with peripartum cardiomyopathy. ( 28578148 )
2017
33
Subsequent reproductive outcome among women with peripartum cardiomyopathy: a nationwide study. ( 29211333 )
2017
34
Value of the neutrophil-to-lymphocyte ratio in predicting left ventricular recovery in patients with peripartum cardiomyopathy. ( 28702739 )
2017
35
Comparison of Clinical Characteristics and Outcomes of Peripartum Cardiomyopathy Between African American and Non-African American Women. ( 29049825 )
2017
36
Reducing the risks for relapse of heart failure in a subsequent pregnancy after peripartum cardiomyopathy? ( 28621169 )
2017
37
Case Series: Spontaneous Relapse After Recovery From Peripartum Cardiomyopathy. ( 29308019 )
2017
38
Outcomes and mortality in parturient and non-parturient patients with peripartum cardiomyopathy: A national readmission database study. ( 29153668 )
2017
39
Complete recovery of fulminant peripartum cardiomyopathy on mechanical circulatory support combined with high-dose bromocriptine therapy. ( 28744986 )
2017
40
Prophylactic use of an intra-aortic balloon pump in a high-risk patient with peripartum cardiomyopathy requiring cesarean delivery. ( 28802997 )
2017
41
What Should Be Generalized Diagnostic Markers for Peripartum Cardiomyopathy? ( 29021419 )
2017
42
Pregnancy and Heart Disease: Pregnancy-Associated Hypertension and Peripartum Cardiomyopathy. ( 29150149 )
2017
43
The Search for a Crystal Ball to Predict Early Recovery From Peripartum Cardiomyopathy? ( 27126284 )
2016
44
Clinical Profi le and Predictors of Outcomes of Patients with Peripartum Cardiomyopathy: The Philippine Heart Center Experience. ( 27942536 )
2016
45
Relaxin-2 and Soluble Flt1 Levels in Peripartum Cardiomyopathy: Results of the Multicenter IPAC Study. ( 26970832 )
2016
46
Reply: BMI Is a Potential Confounder of Post-Partum Relaxin-2 and Short-Term Left Ventricular Function Following Peripartum Cardiomyopathy. ( 27364971 )
2016
47
Right Ventricular Function in Peripartum Cardiomyopathy at Presentation Is Associated With Subsequent Left Ventricular Recovery and Clinical Outcomes. ( 27166247 )
2016
48
Peripartum Cardiomyopathy. ( 27045128 )
2016
49
Cardiac arrest during emergency cesarean section for severe pre-eclampsia and peripartum cardiomyopathy. ( 26927264 )
2016
50
Coincidence of peripartum cardiomyopathy and systemic lupus erythematosus. ( 27150565 )
2016

Variations for Peripartum Cardiomyopathy

Expression for Peripartum Cardiomyopathy

Search GEO for disease gene expression data for Peripartum Cardiomyopathy.

Pathways for Peripartum Cardiomyopathy

Pathways related to Peripartum Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.67 ADRB1 DRD2 GNB3 NRAS SCN5A VEGFA
2
Show member pathways
12.57 CHRM2 DRD2 GNB3 NRAS
3 12.56 FLT1 NRAS RELA VEGFA
4
Show member pathways
12.35 GNB3 NRAS RELA VEGFA
5
Show member pathways
12.33 GNB3 NRAS RELA VEGFA
6
Show member pathways
12.07 DRD2 FLT1 GNB3 NRAS RELA VEGFA
7
Show member pathways
12.04 ADRB1 CHRM2 DRD2 RELA
8
Show member pathways
12.02 ADRB1 MYH7 TTN
9
Show member pathways
11.99 CHRM2 FLT1 GNB3 NRAS PRL RELA
10
Show member pathways
11.94 NRAS RELA VEGFA
11 11.87 FLT1 RELA VEGFA
12
Show member pathways
11.77 ADRB1 CHRM2 DRD2
13 11.77 CHRM2 GNB3 SCN5A VEGFA
14 11.67 FLT1 RELA VEGFA
15 11.65 NRAS RELA VEGFA
16 11.58 ADRB1 DRD2 NRAS
17 11.33 ADRB1 CHRM2 SCN5A
18 11.23 NRAS RELA VEGFA
19 11 FLT1 VEGFA
20 10.96 FLT1 NRAS VEGFA
21 10.95 FLT1 VEGFA
22 10.9 NRAS RELA
23
Show member pathways
10.75 FLT1 VEGFA

GO Terms for Peripartum Cardiomyopathy

Cellular components related to Peripartum Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle myosin complex GO:0005859 8.96 MYH7 TTN
2 Z disc GO:0030018 8.8 MYH7 SCN5A TTN

Biological processes related to Peripartum Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.49 FLT1 VEGFA
2 striated muscle contraction GO:0006941 9.48 MYH7 TTN
3 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.46 PRL RELA
4 positive regulation of receptor internalization GO:0002092 9.43 DRD2 VEGFA
5 temperature homeostasis GO:0001659 9.4 ADRB1 DRD2
6 positive regulation of neuroblast proliferation GO:0002052 9.37 DRD2 VEGFA
7 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.32 ADRB1 DRD2
8 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.26 FLT1 VEGFA
9 cardiac muscle fiber development GO:0048739 9.16 TTN VEGFA
10 cardiac muscle contraction GO:0060048 9.13 MYH7 SCN5A TTN
11 regulation of heart rate GO:0002027 8.8 DRD2 MYH7 SCN5A

Molecular functions related to Peripartum Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transducer activity GO:0004871 9.46 ADRB1 DRD2 GNB3 PDCD1
2 adrenergic receptor activity GO:0004935 8.96 ADRB1 DRD2
3 actinin binding GO:0042805 8.62 RELA TTN

Sources for Peripartum Cardiomyopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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