Peripheral Arterial Occlusive Disease malady

CDC: Peripheral Arterial Disease (PAD) in the Legs or lower extremities is the narrowing or blockage of the vessels that carry blood from the heart to the legs. It is primarily caused by the buildup of fatty plaque in the arteries, which is called atherosclerosis. PAD can occur in any blood vessel, but it is more common in the legs than the arms.²

MalaCards: Peripheral Arterial Occlusive Disease is related to arterial occlusive disease and peripheral vascular disease. An important gene associated with Peripheral Arterial Occlusive Disease is PAOD1 (Peripheral arterial occlusive disease 1), and among its related pathways are RAR-Gamma-RXR-Alpha Degradation and Cell adhesion molecules (CAMs). The compounds hirudin and hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and skeletal muscle, and related mouse phenotypes are renal/urinary system and respiratory system.

Wikipedia: Peripheral vascular disease (PVD), commonly referred to as peripheral arterial disease (PAD) or...⁴⁴ more...

peripheral arterial occlusive disease 7 43

Disease types for peripheral arterial occlusive disease family:

peripheral arterial occlusive disease 1

Diseases related to peripheral arterial occlusive disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 683)

id	Related Disease	Score	Top Affiliating Genes
1	arterial occlusive disease	36.1	VWF, SELE, SELP, VCAM1, CCL2, F3
2	peripheral vascular disease	29.0	VWF, SELE, SELP, SERPINE1, VCAM1, ACE
3	thrombophilia	27.1	VWF, SELE, SELP, SERPINE1, FGA, F5
4	vascular disease	24.4	VWF, SELE, SELP, SERPINE1, VCAM1, GSR
5	type 2 diabetes mellitus	24.1	VWF, SELE, SELP, SERPINE1, VCAM1, GSR
6	homocysteine	21.8	VWF, SELE, SELP, SERPINE1, VCAM1, CD40LG
7	atherosclerosis	20.6	VWF, SELE, SELP, SERPINE1, VCAM1, PAFAH2
8	diabetes mellitus	19.5	VWF, SELE, SELP, SERPINE1, VCAM1, CD40LG
9	malignant spiradenoma	13.6	CD40LG, CD40
10	genee-wiedemann syndrome	13.6	PLAT, THBD
11	cd40 deficiency	13.6	CD40LG, CD40
12	coronary artery disease, modifier of	13.6	CCL2, ACE
13	lipoprotein lipase deficiency	13.5	HP, PLA2G7, PON1
14	mercury poisoning	13.5	IL18, THBD
15	stroke, ischemic	13.5	F5, F2
16	rheumatoid nodulosis	13.5	SELE, VCAM1
17	acute myocarditis	13.5	FGA, PLAT, ACE
18	malignant hypertension	13.5	ACE, ADM
19	blood protein disease	13.4	F5, F2
20	autoimmune thrombocytopenic purpura	13.4	SELP, CD40LG, CD40
21	chronic pulmonary heart disease	13.4	EDN1, ADIPOQ
22	acute poststreptococcal glomerulonephritis	13.4	CCL2, HP, EDN1
23	intracranial thrombosis	13.4	F5, F2, PLAT
24	antithrombin iii deficiency	13.4	FGA, F5, F2
25	aortic atherosclerosis	13.4	F5, PLA2G7, ACE
26	renal hypertension	13.3	EDN1, ACE, ADM
27	prothrombin deficiency	13.3	F5, F2
28	sagittal sinus thrombosis	13.3	F5, F3
29	central serous chorioretinopathy	13.3	SERPINE1, PLAT
30	spotted fever	13.3	F2, THBD, CS
31	patent foramen ovale	13.3	FGA, F5, F2, PLAT
32	hepatic vein thrombosis	13.3	SERPINE1, PLAT
33	plasminogen activator inhibitor type 1 deficiency	13.3	SERPINE1, PLAT
34	plasminogen activator deficiency	13.3	SERPINE1, PLAT
35	oligohydramnios	13.3	EDN1, ACE, ADM
36	atopy	13.3	SELP, PLA2G7
37	high blood pressure	13.2	EDN1, ACE, CS
38	pure red-cell aplasia	13.2	CD40LG, F2, HP
39	ischemic optic neuropathy	13.2	F5, F2, ACE
40	factor xii deficiency	13.2	F5, F3, F2
41	fournier gangrene	13.2	CD40LG, F3, F2
42	lymphoplasmacytic lymphoma	13.2	CD40LG, F3, F2
43	factor x deficiency	13.2	F5, F3, F2
44	achenbach syndrome	13.2	F3, F2, PLAT
45	factor v deficiency	13.2	F5, F3, F2
46	pulmonary hypertension	13.2	FGA, EDN1, THBD, ADM
47	protein-energy malnutrition	13.2	GSR, GPT, HP
48	diabetic angiopathy	13.2	SELE, EDN1, THBD, ADM
49	factor vii deficiency	13.2	F5, F3, F2
50	type 3 von willebrand disease	13.2	VWF, PLAT

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to peripheral arterial occlusive disease:

²²

MGI Mouse Phenotypes related to peripheral arterial occlusive disease:

²⁵ (show all 17)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	10.3	SELP, ADM
2	respiratory system phenotype	MP:0005388	10.3	CYBA, SELP
3	liver/biliary system phenotype	MP:0005370	9.8	ADM, IL6, FGA, PAFAH2
4	integument phenotype	MP:0010771	9.2	F5, F2, F3, SELP, FGA, OSM
5	reproductive system phenotype	MP:0005389	9.0	ADIPOQ, IL6, FGA, CCL2
6	digestive/alimentary phenotype	MP:0005381	8.9	CCL2, F2, IL18, VWF, FGA, EDN1
7	immune system phenotype	MP:0005387	8.7	ADM, PLAT, F2, IL6, SELP, CYBA
8	nervous system phenotype	MP:0003631	7.8	VWF, FGA, F5, F3, F2, HSPA4
9	vision/eye phenotype	MP:0005391	7.6	F3, CCL2, IL6, IL18, FGA, GSR
10	muscle phenotype	MP:0005369	7.6	ADIPOQ, ADM, EDN1, PLAT, F3, ICAM1
11	growth/size phenotype	MP:0005378	7.4	PLAT, SELP, SERPINE1, VCAM1, IL18, IL6
12	tumorigenesis	MP:0002006	7.0	SERPINE1, IL6, ICAM1, F3, HP, ACE
13	behavior/neurological phenotype	MP:0005386	7.0	ADIPOQ, SELP, IL18, SELE, F5, F3
14	cellular phenotype	MP:0005384	5.1	F3, HP, PLAT, CD40, ACE, THBD
15	cardiovascular system phenotype	MP:0005385	4.0	VWF, F3, F2, HP, PLAT, EDN1
16	mortality/aging	MP:0010768	3.9	F2, HSPA4, HP, PLAT, EDN1, ACE
17	homeostasis/metabolism phenotype	MP:0005376	3.8	SELE, VWF, CCL2, F5, ICAM1, F3

Articles related to peripheral arterial occlusive disease:

(show all 39)

id	Title	Authors	Year	Affiliating Genes
1	The role of oxidative stress and antioxidant defenses in Buerger disease and atherosclerotic peripheral arterial occlusive disease. (19128930)	Arslan C.... Denli S.	2010	GSR, PON1
2	Effect of cilostazol treatment on adiponectin and sol uble CD40 ligand levels in diabetic patients with peripheral arterial occlusion disease. (19282610)	Hsieh C.J.... Wang P.W.	2009	CD40LG, ADIPOQ
3	Thrombophilias and peripheral arterial occlusive disease (18554834)	le Hello C.... Constans J.	2008	F5
4	Association between inflammatory markers and the interleukin-6 -174 G/C polymorphism is abolished in peripheral arterial occlusive disease. (18091699)	Potaczek D.P.... Szczeklik A.	2007	IL6, FGA
5	No effect of homocysteine-lowering therapy on vascular inflammation and haemostasis in peripheral arterial occlusive disease. (16634837)	Schernthaner G.H.... Schernthaner G.	2006	CCL2, IL18, F3
6	Markers of vascular inflammation are associated with the extent of atherosclerosis assessed as angiographic score and treadmill walking distances in patients with peripheral arterial occlusive disease. (16669409)	Nylaende M.... Seljeflot I.	2006	IL6, CCL2
7	A single nucleotide polymorphism in the plasma PAF acetylhydrolase gene and risk of atherosclerosis in Japanese patients with peripheral artery occlusive disease. (16650870)	Unno N.... Konno H.	2006	PLA2G7, PAFAH2
8	Adiponectin and inflammatory markers in peripheral arterial occlusive disease. (16321391)	Iwashima Y.... Kawano Y.	2006	ADIPOQ
9	Double jeopardy: how soluble P-selectin activates leukocytes in peripheral arterial occlusive disease. (16397153)	Galkina E.... Ley K.	2006	SELP
10	Mutation in factor II and factor V gene in patients with peripheral arterial occlusive disease (16906235)	Abukishe A.... Bruhn H.D.	2006	F2, F5
11	Raised plasma soluble P-selectin in peripheral arterial occlusive disease enhances leukocyte adhesion. (16339486)	Woollard K.J.... Chin-Dusting J.	2006	SELP
12	Interleukin-1beta C+3953T gene polymorphism and peripheral arterial occlusive disease in Polish population (16541711)	Potaczek D.P.... Sanak M.	2005	IL1B
13	LDL-apheresis improves peripheral arterial occlusive disease with an implication for anti-inflammatory effects. (15880405)	Kobayashi S.... Ohtake T.	2005	CCL2
14	Lack of an association between angiotensin converting enzyme gene polymorphism and peripheral arterial occlusive disease. (15675183)	Karagiannis A.... Zamboulis C.	2004	ACE
15	Plasma adrenomedullin concentration is increased in patients with peripheral arterial occlusive disease associated with vascular inflammation. (14759562)	Suzuki Y.... Kawano Y.	2004	ADM
16	Reteplase monotherapy and reteplase/abciximab combination therapy in peripheral arterial occlusive disease: results from the RELAX trial. (15028807)	Ouriel K.... Duda S.	2004	PLAT
17	Clot lysis in a primate model of peripheral arterial occlusive disease with use of systemic or intraarterial reteplase: addition of abciximab results in improved vessel reperfusion. (14963184)	Nakada M.T.... Jordan R.E.	2004	PLAT
18	The K469E polymorphism of the ICAM-1 gene is a risk factor for peripheral arterial occlusive disease. (12192299)	Gaetani E.... Pola P.	2002	ICAM1
19	Localization of a gene for peripheral arterial occlusive disease to chromosome 1p31. (11833003)	Gudmundsson G.... Stefansson K.	2002	PAOD1
20	HSP70 expression in skeletal muscle of patients with peripheral arterial occlusive disease. (12217291)	Liu Y.... Steinacker J.M.	2002	HSPA4
21	Initial experience with the combination of reteplase and abciximab for thrombolytic therapy in peripheral arterial occlusive disease: a pilot study. (11788692)	Drescher P.... Rilling W.S.	2002	PLAT
22	The -174 G/C polymorphism of the interleukin-6 gene promoter is associated with peripheral artery occlusive disease. (12217290)	Flex A.... Pola P.	2002	IL6
23	Factor II G20210A and factor V G1691A gene mutations and peripheral arterial occlusive disease. (10669148)	Renner W.... Pilger E.	2000	F2, F5
24	Platelets and cytokines in concert with endothelial activation in patients with peripheral arterial occlusive disease. (10759010)	Tsakiris D.A.... Marbet G.A.	2000	CD40LG, VCAM1, CD40
25	C242T polymorphism of the p22 phox gene is not associated with peripheral arterial occlusive disease. (10996353)	Renner W.... Pilger E.	2000	CYBA
26	Chronic peripheral arterial occlusive disease, platelet glycoproteins GPIIb-IIIa and GP Ib-IX, plasma von Willebrand factor and plasma fibrinogen concentrations in patients with type 2 diabetes mellitus (11236240)	Gosk-Bierska I.... Ciosek W.	2000	VWF
27	Elevated levels of soluble E-selectin in diabetic patients with severe symptomatic peripheral arterial occlusive disease requiring angioplasty. A possible role in diabetic vascular disease? (10905802)	Elhadd T.A.... Belch J.J.	2000	SELE
28	Angiotensin-converting enzyme gene insertion/deletion polymorphism and carotid artery wall thickness in patients with peripheral arterial occlusive disease. (11305733)	Taute B.M.... Podhaisky H.	2000	ACE
29	Treadmill exercise-induced release of endothelin-1 in patients with peripheral arterial occlusive disease at Fontaine stage IIb. (10853680)	Mangiafico R.A.... Attina T.	2000	EDN1
30	Thrombolytic therapy with use of alteplase (rt-PA) in peripheral arterial occlusive disease: review of the clinical literature. The Advisory Panel. (10716384)	Semba C.P.... Matalon T.A.	2000	PLAT
31	Haptoglobin polymorphism and peripheral arterial occlusive disease. (10488955)	Delanghe J.... Clement D.	1999	HP
32	Circulating cell adhesion molecules and endothelial markers before and after transluminal angioplasty in peripheral arterial occlusive disease. (9920521)	Tsakiris D.A.... Marbet G.A.	1999	VWF, SELP, SELE
33	Alteration of the fibrinolytic system in patients with peripheral arterial occlusive disease. (10409921)	Poredos P.... Gacnik A.	1999	PLAT
34	Changes in the fibrinolytic system in patients with peripheral arterial occlusive disease undergoing percutaneous transluminal angioplasty. (10336240)	Roller R.E.... Wojta J.	1999	SERPINE1
35	Decrease in P-selectin levels in patients with hypercholesterolaemia and peripheral arterial occlusive disease after lipid-lowering treatment. (10355866)	Kirk G.... Belch J.J.	1999	SELP
36	Plasma endothelin-1 levels in patients with peripheral arterial occlusive disease at different Fontaine's stages. (10230252)	Mangiafico R.A.... Santangelo B.	1999	EDN1
37	Angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral arterial occlusive disease. (9747149)	Taute B.M.... Podhaisky H.	1998	ACE
38	Instrumental and metabolic evaluation of patients affected by peripheral arterial occlusive disease (PAOD) following surgical revascularization surgery. (9287278)	Pastoris O.... Dossena M.	1996	CS, GPT
39	D-dimer in local thrombolytic therapy with low doses of recombinant human tissue-type plasminogen activator (rt-PA) in patients with peripheral arterial occlusive disease. (2125370)	Koppensteiner R.... Ehringer H.	1990	PLAT

Genes related to peripheral arterial occlusive disease according to GeneCards:

(show all 33)

id	Symbol	Description	Score	GeneCards Section Context
1	PAOD1	Peripheral arterial occlusive disease 1	11.1	Publications, Aliases & Descriptions
2	PAFAH2	platelet-activating factor acetylhydrolase 2, 40kDa	11.0	Publications
3	CS	citrate synthase	11.0	Publications
4	CYBA	cytochrome b-245, alpha polypeptide	11.0	Publications
5	PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	11.0	Publications
6	OSM	oncostatin M	11.0	Publications
7	PLAT	plasminogen activator, tissue	11.0	Publications
8	HP	haptoglobin	11.0	Publications
9	FGA	fibrinogen alpha chain	11.0	Publications
10	ADM	adrenomedullin	11.0	Publications
11	PON1	paraoxonase 1	11.0	Publications
12	CD40LG	CD40 ligand	11.0	Publications
13	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
14	CD40	CD40 molecule, TNF receptor superfamily member 5	11.0	Publications
15	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0	Publications
16	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
17	SELE	selectin E	11.0	Publications
18	THBD	thrombomodulin	11.0	Publications
19	VCAM1	vascular cell adhesion molecule 1	11.0	Publications
20	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
21	GSR	glutathione reductase	11.0	Publications
22	VWF	von Willebrand factor	11.0	Publications
23	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
24	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
25	ADIPOQ	adiponectin, C1Q and collagen domain containing	11.0	Publications
26	EDN1	endothelin 1	11.0	Publications
27	F2	coagulation factor II (thrombin)	11.0	Publications
28	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
29	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
30	HSPA4	heat shock 70kDa protein 4	11.0	Publications
31	ICAM1	intercellular adhesion molecule 1	11.0	Publications
32	IL1B	interleukin 1, beta	11.0	Publications
33	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications

Pathways related to peripheral arterial occlusive disease according to GeneDecks:

(show all 30)

id	Pathway	Score	Top Affiliating Genes
1	RAR-Gamma-RXR-Alpha Degradation36	10.6	OSM
2	Cell adhesion molecules (CAMs)20	10.4	CD40, SELP
3	IL-6 Pathway36	10.1	CCL2, IL18, OSM
4	NFAT Signaling and Lymphocyte Interactions36	10.0	CCL2
5	Intrinsic Prothrombin Activation Pathway36	9.7	FGA, F5, F2, THBD
6	Immune System38	9.6	ICAM1, VCAM1, CD40, IL18
7	Extrinsic Prothrombin Activation Pathway36	9.4	FGA, F2, F5, THBD, F3
8	Blood Coagulation Cascade36	9.4	THBD, F2, F3, F5, FGA
9	Immune response MIF-mediated glucocorticoid regulation10	9.2	VCAM1, ICAM1, IL6
10	Immune response_MIF-mediated glucocorticoid regulation41	9.2	IL6, VCAM1, ICAM1
11	NOD-like receptor signaling pathway20	9.0	IL1B, IL6, CCL2, IL18
12	LDL Oxidation in Atherogenesis36	9.0	ICAM1, VCAM1, IL1B, CCL2
13	Blood Coagulation Signaling Pathways37	8.9	THBD, PLAT, F2, VWF, F5, SERPINE1
14	MIF Mediated Glucocorticoid Regulation36	8.9	CCL2, OSM, IL6, IL1B, IL18
15	MIF Regulation of Innate Immune Cells36	8.9	IL1B, OSM, CCL2, IL18, IL6
16	all-trans-Retinoic Acid Signaling in Brain36	8.9	OSM, CCL2, IL6, IL1B, IL18
17	Cytokine Network36	8.9	IL1B, IL18, IL6
18	PEDF Induced Signaling36	8.8	OSM, CCL2, IL6, IL1B, IL18
19	Endothelin-1 Signaling Pathway36	8.8	OSM, IL18, IL1B, IL6, EDN1
20	Complement and coagulation cascades20	8.8	VWF, THBD, PLAT, F2, F3, F5
21	Chagas disease (American trypanosomiasis)20	8.7	SERPINE1, ACE, CCL2, IL6, IL1B
22	STAT3 Pathway36	8.6	OSM, CCL2, IL6, IL1B, IL18
23	Cytokine-cytokine receptor interaction20	8.6	IL6, OSM, IL1B, IL18, CD40LG, CCL2
24	Antioxidant Action of Vitamin-C36	8.5	IL1B, IL18, PLA2G7, OSM, IL6, CCL2
25	Immune response IL-1 signaling pathway10	8.5	EDN1, F3, IL1B, IL6, SERPINE1
26	Immune response_IL-1 signaling pathway41	8.4	SERPINE1, IL1B, IL6, F3, EDN1
27	Rheumatoid arthritis20	8.4	CCL2, IL6, IL1B, IL18, ICAM1
28	Influenza A20	8.3	CCL2, IL6, IL1B, IL18, ICAM1
29	African trypanosomiasis20	8.3	IL6, SELE, ICAM1, VCAM1, IL1B, IL18
30	Malaria20	7.5	IL18, SELE, SELP, VCAM1, CD40LG, CD40

Compounds related to peripheral arterial occlusive disease according to GeneDecks:

(show top 50)    (show all 345)

id	Compound	Score	Top Affiliating Genes
1	hirudin32	10.3	FGA, F5, THBD
2	hyaluronic acid32 18	10.7	GPT, F2, THBD, OSM
3	argatroban32 9 9	11.3	SELP, FGA, F5, F3, F2, THBD
4	aprotinin32 9 9	11.2	VWF, SELP, FGA, F5, F2, PLAT
5	bivalirudin32 9 9	11.1	SELP, FGA, F5, F3, F2, PLAT
6	aspartate32	9.1	SELP, CD40LG, GSR, IL18, F5, F2
7	ppack32	8.9	VWF, SELP, CD40LG, FGA, CCL2, F3
8	pge232	8.9	SELE, VCAM1, GSR, HP, PLA2G7, EDN1
9	epinephrine32 9 18 9	11.8	HP, F2, F3, SELE, SELP, GSR
10	pravastatin32 34 9 18 9	12.8	SELE, SELP, SERPINE1, IL18, IL6, CCL2
11	sb 20358032 42	9.8	VCAM1, IL6, HSPA4, EDN1, ADIPOQ, SELE
12	heparin32 9 18 9	11.7	SERPINE1, FGA, F3, F2, ADIPOQ, HP
13	mycophenolate mofetil32 9 9	10.7	CD40, IL18, GPT, F5, THBD, CD40LG
14	quinapril32 9 9	10.7	VWF, SELE, SELP, SERPINE1, PLAT, EDN1
15	pge132	8.6	CD40, FGA, IL18, GPT, F5, PLAT
16	n acetylcysteine32	8.6	VWF, SELE, SELP, VCAM1, CD40, IL18
17	endotoxin32	8.6	CD40, FGA, IL18, F5, F3, HP
18	kininogen32	8.3	VWF, SELP, SERPINE1, F5, F3, F2
19	fluvastatin32 34 9 9	11.2	VWF, SELP, SERPINE1, VCAM1, CD40, IL6
20	warfarin32 34 9 18 9	12.2	VWF, SELP, FGA, GPT, F5, F3
21	losartan32 34 9 9	11.0	THBD, ADM, ADIPOQ, ACE, EDN1, PLAT
22	polysaccharide32	7.8	PON1, SELE, SELP, VCAM1, CD40LG, IL18
23	8-isoprostane32	7.6	SELE, SERPINE1, VCAM1, IL6, CCL2, ICAM1
24	norepinephrine32 9 18 9	10.6	VWF, SELE, SELP, VCAM1, CD40LG, FGA
25	fenofibrate32 9 9	9.2	ADIPOQ, PON1, PLA2G7, ICAM1, SELE, SELP
26	homocysteine32 18	8.2	VWF, SELE, SELP, SERPINE1, VCAM1, IL18
27	polymyxin b32	7.1	CCL2, SELE, SERPINE1, VCAM1, IL6, THBD
28	herbimycin a32 42	7.9	HSPA4, EDN1, OSM, ICAM1, CCL2, IL6
29	adenylate32	6.8	ADIPOQ, ADM, CS, SELE, VWF, SELP
30	rantes32	6.6	CD40LG, IL18, IL1B, IL6, CCL2, OSM
31	cyclosporin a32 42	7.5	ADM, CS, THBD, EDN1, PLAT, HP
32	creatinine32	6.5	F5, F3, HSPA4, HP, EDN1, ACE
33	aspirin32 34 18	8.4	PLA2G7, PLAT, ACE, THBD, PON1, ADIPOQ
34	lipid32	6.2	FGA, IL18, IL6, CCL2, GPT, HP
35	genistein32 9 18 9	9.1	SELP, SERPINE1, VCAM1, CD40LG, CD40, GSR
36	serine32	6.0	SELE, ADIPOQ, PON1, SERPINE1, VCAM1, CD40LG
37	atorvastatin32 34 9 18 9	9.8	GPT, F5, ICAM1, PLA2G7, PLAT, EDN1
38	histamine32 18	6.7	IL6, CCL2, PLAT, EDN1, THBD, OSM
39	alanine32	5.7	VWF, SELE, VCAM1, CD40LG, GSR, IL18
40	cycloheximide32	5.7	SELE, SERPINE1, CD40, IL18, IL1B, IL6
41	simvastatin32 34 42 9 18 9	10.7	F5, ICAM1, F3, F2, PLAT, THBD
42	prostacyclin32	5.6	ADIPOQ, VWF, SELE, SELP, SERPINE1, VCAM1
43	actinomycin d32	5.4	F3, ICAM1, CCL2, IL6, IL1B, CD40
44	lactate32	5.3	THBD, HP, HSPA4, F2, ICAM1, F5
45	retinoic acid32 42 18	7.1	VWF, SELP, SERPINE1, VCAM1, CD40LG, CD40
46	cholesterol32 9 18 9	8.1	IL18, IL6, CCL2, GPT, F5, HSPA4
47	dexamethasone32 42 34 9 9	9.1	ADIPOQ, ADM, IL18, CD40, CD40LG, VCAM1
48	vegf32	4.7	VWF, SELE, SELP, SERPINE1, VCAM1, CD40LG
49	nitric oxide32 9 18 9	7.3	ADM, CS, OSM, IL1B, IL18, CD40
50	fibrinogen32	4.1	THBD, IL18, FGA, CD40, CD40LG, VCAM1

Cellular components related to peripheral arterial occlusive disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule lumen	GO:031093	9.5	VWF, SERPINE1, FGA, F5
2	external side of plasma membrane	GO:009897	8.0	ACE, ICAM1, FGA, CD40, CD40LG, VCAM1
3	extracellular region	GO:005576	5.7	IL6, ADIPOQ, VWF, SERPINE1, CD40, FGA
4	extracellular space	GO:005615	3.9	ADIPOQ, F5, IL6, IL1B, SELE, SELP

Biological processes related to peripheral arterial occlusive disease according to GeneDecks:

(show all 43)

id	Name	GO ID	Score	Top Affiliating Genes
1	leukocyte tethering or rolling	GO:050901	10.2	SELP, SELE, VCAM1
2	positive regulation of endothelial cell apoptotic process	GO:2000353	10.2	CD40LG, CD40
3	maternal process involved in parturition	GO:060137	10.1	EDN1, CCL2
4	regulation of vascular endothelial growth factor production	GO:010574	10.1	IL6, CCL2
5	negative regulation of hormone secretion	GO:046888	10.1	EDN1, ADIPOQ, OSM
6	fibrinolysis	GO:042730	10.0	SERPINE1, F2, PLAT
7	regulation of immunoglobulin secretion	GO:051023	10.0	CD40LG, CD40
8	negative regulation of blood coagulation	GO:030195	10.0	SERPINE1, THBD, EDN1
9	negative regulation of fibrinolysis	GO:051918	10.0	SERPINE1, THBD, F2
10	positive regulation of inflammatory response	GO:050729	9.9	PLA2G7, SERPINE1, IL18
11	defense response to Gram-negative bacterium	GO:050829	9.8	SELP, SERPINE1, IL6
12	platelet degranulation	GO:002576	9.7	SERPINE1, F5, VWF, FGA, SELP
13	cellular response to hydrogen peroxide	GO:070301	9.7	IL6, F3, IL18
14	response to amino acid stimulus	GO:043200	9.7	EDN1, CCL2, ICAM1
15	positive regulation of monocyte chemotactic protein-1 production	GO:071639	9.6	IL1B, ADIPOQ
16	heterophilic cell-cell adhesion	GO:007157	9.6	ICAM1, VCAM1, SELE, SELP
17	membrane to membrane docking	GO:022614	9.6	VCAM1, ICAM1
18	lipopolysaccharide-mediated signaling pathway	GO:031663	9.6	IL18, IL1B, CCL2
19	cellular response to interleukin-1	GO:071347	9.6	EDN1, CCL2, ICAM1
20	positive regulation of interferon-gamma production	GO:032729	9.6	IL1B, IL18, CD40LG
21	regulation of immune response	GO:050776	9.6	VCAM1, CD40LG, CD40, ICAM1
22	cellular response to tumor necrosis factor	GO:071356	9.5	EDN1, ICAM1, CCL2, IL18
23	cellular response to organic cyclic compound	GO:071407	9.5	CCL2, IL1B, IL18
24	leukocyte cell-cell adhesion	GO:007159	9.5	SELE, SELP, VCAM1, CD40LG, ICAM1
25	response to lipopolysaccharide	GO:032496	9.4	THBD, F3, EDN1, SELE, ADM, SELP
26	neutrophil chemotaxis	GO:030593	9.3	CCL2, IL1B, EDN1
27	positive regulation of interleukin-8 production	GO:032757	9.3	SERPINE1, ADIPOQ, IL1B, IL18
28	leukocyte migration	GO:050900	9.2	ICAM1, THBD, SELP, F2
29	response to heat	GO:009408	9.2	CCL2, HSPA4, OSM, IL1B
30	positive regulation of angiogenesis	GO:045766	9.2	SERPINE1, ADM, IL1B, F3
31	positive regulation of protein phosphorylation	GO:001934	9.1	ADIPOQ, CD40, IL1B, F2
32	anti-apoptosis	GO:006916	9.1	F3, CCL2, IL1B, PAFAH2, CD40LG
33	aging	GO:007568	9.1	CCL2, F3, ADM, IL1B, VCAM1
34	positive regulation of nitric oxide biosynthetic process	GO:045429	9.0	IL1B, EDN1, ICAM1
35	cell adhesion	GO:007155	8.8	CCL2, VCAM1, SELP, F5, ICAM1, VWF
36	blood coagulation	GO:007596	8.6	VWF, SERPINE1, FGA, F5, F3, PLAT
37	positive regulation of T cell proliferation	GO:042102	8.6	VCAM1, IL1B, IL6
38	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.5	IL1B, CD40, ICAM1, IL6
39	platelet activation	GO:030168	8.5	FGA, F2, VWF, SELP, SERPINE1, CD40LG
40	response to hypoxia	GO:001666	8.5	ADIPOQ, IL18, IL1B, CCL2, PLAT, EDN1
41	response to glucocorticoid stimulus	GO:051384	8.5	IL1B, PLAT, SERPINE1, CCL2, IL6, ADM
42	cytokine-mediated signaling pathway	GO:019221	8.4	VCAM1, ICAM1, IL6, IL1B, CCL2
43	inflammatory response	GO:006954	8.3	CYBA, CCL2, IL1B, IL18, CD40, CD40LG

Molecular functions related to peripheral arterial occlusive disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	1-alkyl-2-acetylglycerophosphocholine esterase activity	GO:003847	10.2	PLA2G7, PAFAH2
2	oligosaccharide binding	GO:070492	10.0	SELE, SELP
3	sialic acid binding	GO:033691	9.8	SELP, SELE, ADIPOQ
4	eukaryotic cell surface binding	GO:043499	9.5	SELP, FGA, ADIPOQ
5	receptor binding	GO:005102	9.0	SERPINE1, FGA, CCL2, F2, ADM, ADIPOQ
6	cytokine activity	GO:005125	8.1	IL6, ADIPOQ, OSM, EDN1, IL1B, IL18